Benjamin Davidson, Peter Giacobbe, Tony P George, Sean M Nestor, Jennifer S Rabin, Maged Goubran, Alexander J Nyman, Anusha Baskaran, Ying Meng, Christopher B Pople, Simon J Graham, Fred Tam, Clement Hamani, Nir Lipsman
Alcohol use disorder (AUD) is a highly prevalent, often refractory, medical illness. The symptoms of AUD are driven by dysfunction in several neurocircuits centered on the nucleus accumbens (NAc). Case reports and animal studies suggest NAc-DBS may be an effective harm-reduction treatment in severe AUD. Six patients with severe, refractory AUD underwent NAc-DBS. Safety metrics and clinical outcomes were recorded. Positron emission tomography (FDG-PET) was used to measure glucose metabolism in the NAc at baseline and 6 months...
July 21, 2022: Molecular Psychiatry