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https://www.readbyqxmd.com/read/27825979/functional-circuit-mapping-of-striatal-output-nuclei-using-simultaneous-deep-brain-stimulation-and-fmri
#1
Nathalie Van Den Berge, Daniel L Albaugh, Andrew Salzwedel, Christian Vanhove, Roel Van Holen, Wei Gao, Garret D Stuber, Yen-Yu Ian Shih
The substantia nigra pars reticulata (SNr) and external globus pallidus (GPe) constitute the two major output targets of the rodent striatum. Both the SNr and GPe converge upon thalamic relay nuclei (directly or indirectly, respectively), and are traditionally modeled as functionally antagonistic relay inputs. However, recent anatomical and functional studies have identified unanticipated circuit connectivity in both the SNr and GPe, demonstrating their potential as far more than relay nuclei. In the present study, we employed simultaneous deep brain stimulation and functional magnetic resonance imaging (DBS-fMRI) with cerebral blood volume (CBV) measurements to functionally and unbiasedly map the circuit- and network level connectivity of the SNr and GPe...
November 5, 2016: NeuroImage
https://www.readbyqxmd.com/read/27601003/functional-magnetic-resonance-imaging-of-electrical-and-optogenetic-deep-brain-stimulation-at-the-rat-nucleus-accumbens
#2
Daniel L Albaugh, Andrew Salzwedel, Nathalie Van Den Berge, Wei Gao, Garret D Stuber, Yen-Yu Ian Shih
Deep brain stimulation of the nucleus accumbens (NAc-DBS) is an emerging therapy for diverse, refractory neuropsychiatric diseases. Although DBS therapy is broadly hypothesized to work through large-scale neural modulation, little is known regarding the neural circuits and networks affected by NAc-DBS. Using a healthy, sedated rat model of NAc-DBS, we employed both evoked- and functional connectivity (fc) MRI to examine the functional circuit and network changes achieved by electrical NAc stimulation. Optogenetic-fMRI experiments were also undertaken to evaluate the circuit modulation profile achieved by selective stimulation of NAc neurons...
September 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27445706/the-co-evolution-of-neuroimaging-and-psychiatric-neurosurgery
#3
REVIEW
Timothy G Dyster, Charles B Mikell, Sameer A Sheth
The role of neuroimaging in psychiatric neurosurgery has evolved significantly throughout the field's history. Psychiatric neurosurgery initially developed without the benefit of information provided by modern imaging modalities, and thus lesion targets were selected based on contemporary theories of frontal lobe dysfunction in psychiatric disease. However, by the end of the 20th century, the availability of structural and functional magnetic resonance imaging (fMRI) allowed for the development of mechanistic theories attempting to explain the anatamofunctional basis of these disorders, as well as the efficacy of stereotactic neuromodulatory treatments...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27286467/combined-invasive-subcortical-and-non-invasive-surface-neurophysiological-recordings-for-the-assessment-of-cognitive-and-emotional-functions-in-humans
#4
Carlos Trenado, Saskia Elben, David Petri, Jan Hirschmann, Stefan J Groiss, Jan Vesper, Alfons Schnitzler, Lars Wojtecki
In spite of the success in applying non-invasive electroencephalography (EEG), magneto-encephalography (MEG) and functional magnetic resonance imaging (fMRI) for extracting crucial information about the mechanism of the human brain, such methods remain insufficient to provide information about physiological processes reflecting cognitive and emotional functions at the subcortical level. In this respect, modern invasive clinical approaches in humans, such as deep brain stimulation (DBS), offer a tremendous possibility to record subcortical brain activity, namely local field potentials (LFPs) representing coherent activity of neural assemblies from localized basal ganglia or thalamic regions...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27251623/dopamine-release-in-the-nonhuman-primate-caudate-and-putamen-depends-upon-site-of-stimulation-in-the-subthalamic-nucleus
#5
Hoon-Ki Min, Erika K Ross, Hang Joon Jo, Shinho Cho, Megan L Settell, Ju Ho Jeong, Penelope S Duffy, Su-Youne Chang, Kevin E Bennet, Charles D Blaha, Kendall H Lee
UNLABELLED: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for medically refractory Parkinson's disease. Although DBS has recognized clinical utility, its biologic mechanisms are not fully understood, and whether dopamine release is a potential factor in those mechanisms is in dispute. We tested the hypothesis that STN DBS-evoked dopamine release depends on the precise location of the stimulation site in the STN and the site of recording in the caudate and putamen...
June 1, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27160467/anterior-thalamic-deep-brain-stimulation-functional-activation-patterns-in-a-large-animal-model
#6
William S Gibson, Erika K Ross, Seong Rok Han, Jamie J Van Gompel, Hoon-Ki Min, Kendall H Lee
BACKGROUND: Deep brain stimulation (DBS) of the anterior thalamic nucleus (ATN) exerts its effects by modulating neural circuits involved in seizures. However, these networks remain incompletely characterized. OBJECTIVE: Investigate the effects of ATN DBS on network activity in a large animal model using 3-T fMRI. METHODS: Anesthetized swine underwent ATN DBS using stimulation parameters applied in the Stimulation of the Anterior Thalamus for the Treatment of Epilepsy (SANTE) trial...
September 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27031602/non-human-primates-in-neuroscience-research-the-case-against-its-scientific-necessity
#7
REVIEW
Jarrod Bailey, Kathy Taylor
Public opposition to non-human primate (NHP) experiments is significant, yet those who defend them cite minimal harm to NHPs and substantial human benefit. Here we review these claims of benefit, specifically in neuroscience, and show that: a) there is a default assumption of their human relevance and benefit, rather than robust evidence; b) their human relevance and essential contribution and necessity are wholly overstated; c) the contribution and capacity of non-animal investigative methods are greatly understated; and d) confounding issues, such as species differences and the effects of stress and anaesthesia, are usually overlooked...
March 2016: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/27001680/the-impact-of-mirth-inducing-ventral-striatal-deep-brain-stimulation-on-functional-and-effective-connectivity
#8
William S Gibson, Shinho Cho, Osama A Abulseoud, Krzysztof R Gorny, Joel P Felmlee, Kirk M Welker, Bryan T Klassen, Hoon-Ki Min, Kendall H Lee
Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is an investigational therapy for treatment-resistant obsessive-compulsive disorder. The ability of VC/VS DBS to evoke spontaneous mirth in patients, often accompanied by smiling and laughter, is clinically well documented. However, the neural correlates of DBS-evoked mirth remain poorly characterized. Patients undergoing VC/VS DBS surgery underwent intraoperative evaluation in which mirth-inducing and non-mirth-inducing stimulation localizations were identified...
March 21, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/26888415/distinct-neurobiological-signatures-of-brain-connectivity-in-depression-subtypes-during-natural-viewing-of-emotionally-salient-films
#9
C C Guo, M P Hyett, V T Nguyen, G B Parker, M J Breakspear
BACKGROUND: Establishing an evidence-based diagnostic system informed by the biological (dys)function of the nervous system is a major priority in psychiatry. This objective, however, is often challenged by difficulties in identifying homogeneous clinical populations. Melancholia, a biological and endogenous subtype for major depressive disorder, presents a canonical test case in the search of biological nosology. METHOD: We employed a unique combination of naturalistic functional magnetic resonance imaging (fMRI) paradigms - resting state and free viewing of emotionally salient films - to search for neurobiological signatures of depression subtypes...
May 2016: Psychological Medicine
https://www.readbyqxmd.com/read/26780572/fornix-deep-brain-stimulation-circuit-effect-is-dependent-on-major-excitatory-transmission-via-the-nucleus-accumbens
#10
Erika K Ross, Joo Pyung Kim, Megan L Settell, Seong Rok Han, Charles D Blaha, Hoon-Ki Min, Kendall H Lee
INTRODUCTION: Deep brain stimulation (DBS) is a circuit-based treatment shown to relieve symptoms from multiple neurologic and neuropsychiatric disorders. In order to treat the memory deficit associated with Alzheimer's disease (AD), several clinical trials have tested the efficacy of DBS near the fornix. Early results from these studies indicated that patients who received fornix DBS experienced an improvement in memory and quality of life, yet the mechanisms behind this effect remain controversial...
March 2016: NeuroImage
https://www.readbyqxmd.com/read/26525655/deep-brain-stimulation-of-the-ventromedial-prefrontal-cortex-causes-reorganization-of-neuronal-processes-and-vasculature
#11
M Mallar Chakravarty, Clement Hamani, Alonso Martinez-Canabal, Jacob Ellegood, Christine Laliberté, José N Nobrega, Tejas Sankar, Andres M Lozano, Paul W Frankland, Jason P Lerch
BACKGROUND: Chronic high-frequency electrical deep brain stimulation (DBS) of the subcallosal cingulate region is currently being investigated clinically as a therapy for treatment of refractory depression. Experimental DBS of the homologous region, the ventromedial prefrontal cortex (VMPFC), in rodent models has previously demonstrated anti-depressant-like effects. Our goal was to determine if structural remodeling accompanies the alterations of brain function previously observed as a result of chronic DBS...
January 15, 2016: NeuroImage
https://www.readbyqxmd.com/read/26509113/resting-state-functional-magnetic-resonance-imaging-of-the-subthalamic-microlesion-and-stimulation-effects-in-parkinson-s-disease-indications-of-a-principal-role-of-the-brainstem
#12
Štefan Holiga, Karsten Mueller, Harald E Möller, Dušan Urgošík, Evžen Růžička, Matthias L Schroeter, Robert Jech
During implantation of deep-brain stimulation (DBS) electrodes in the target structure, neurosurgeons and neurologists commonly observe a "microlesion effect" (MLE), which occurs well before initiating subthalamic DBS. This phenomenon typically leads to a transitory improvement of motor symptoms of patients suffering from Parkinson's disease (PD). Mechanisms behind MLE remain poorly understood. In this work, we exploited the notion of ranking to assess spontaneous brain activity in PD patients examined by resting-state functional magnetic resonance imaging in response to penetration of DBS electrodes in the subthalamic nucleus...
2015: NeuroImage: Clinical
https://www.readbyqxmd.com/read/26406128/technological-advances-in-deep-brain-stimulation
#13
REVIEW
Ismail Ughratdar, Michael Samuel, Keyoumars Ashkan
Functional and stereotactic neurosurgery has always been regarded as a subspecialty based on and driven by technological advances. However until recently, the fundamentals of deep brain stimulation (DBS) hardware and software design had largely remained stagnant since its inception almost three decades ago. Recent improved understanding of disease processes in movement disorders as well clinician and patient demands has resulted in new avenues of development for DBS technology. This review describes new advances both related to hardware and software for neuromodulation...
2015: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/26193653/functional-mri-during-hippocampal-deep-brain-stimulation-in-the-healthy-rat-brain
#14
Nathalie Van Den Berge, Christian Vanhove, Benedicte Descamps, Ine Dauwe, Pieter van Mierlo, Kristl Vonck, Vincent Keereman, Robrecht Raedt, Paul Boon, Roel Van Holen
Deep Brain Stimulation (DBS) is a promising treatment for neurological and psychiatric disorders. The mechanism of action and the effects of electrical fields administered to the brain by means of an electrode remain to be elucidated. The effects of DBS have been investigated primarily by electrophysiological and neurochemical studies, which lack the ability to investigate DBS-related responses on a whole-brain scale. Visualization of whole-brain effects of DBS requires functional imaging techniques such as functional Magnetic Resonance Imaging (fMRI), which reflects changes in blood oxygen level dependent (BOLD) responses throughout the entire brain volume...
2015: PloS One
https://www.readbyqxmd.com/read/26153778/anterior-thalamic-nucleus-deep-brain-stimulation-dbs-for-drug-resistant-complex-partial-seizures-cps-with-or-without-generalization-long-term-evaluation-and-predictive-outcome
#15
Massimo Piacentino, Christine Durisotti, Pier Gaetano Garofalo, Paolo Bonanni, Anna Volzone, Federica Ranzato, Giacomo Beggio
BACKGROUND: Drug-resistant epileptic patients account for 40 % of cases of epilepsy. Consequently, specific therapeutic options could be surgical resection or, if not indicated, deep brain stimulation (DBS). The aim of this study is to review data from patients affected by drug-resistant complex partial epilepsy with or without generalization treated by anterior thalamic nucleus (AN) DBS to evaluate the efficacy and potential future applications of this approach as a standard method for palliative seizure control...
September 2015: Acta Neurochirurgica
https://www.readbyqxmd.com/read/26110109/neuroimaging-and-neuromodulation-approaches-to-study-eating-behavior-and-prevent-and-treat-eating-disorders-and-obesity
#16
REVIEW
D Val-Laillet, E Aarts, B Weber, M Ferrari, V Quaresima, L E Stoeckel, M Alonso-Alonso, M Audette, C H Malbert, E Stice
Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain...
2015: NeuroImage: Clinical
https://www.readbyqxmd.com/read/26068173/the-genetic-absence-epilepsy-rat-from-strasbourg-as-a-model-to-decipher-the-neuronal-and-network-mechanisms-of-generalized-idiopathic-epilepsies
#17
REVIEW
Antoine Depaulis, Olivier David, Stéphane Charpier
First characterized in 1982, the genetic absence epilepsy rat from Strasbourg (GAERS) has emerged as an animal model highly reminiscent of a specific form of idiopathic generalized epilepsy. Both its electrophysiological (spike-and-wave discharges) and behavioral (behavioral arrest) features fit well with those observed in human patients with typical absence epilepsy and required by clinicians for diagnostic purposes. In addition, its sensitivity to antiepileptic drugs closely matches what has been described in the clinic, making this model one of the most predictive...
February 15, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/26061738/the-safety-of-using-body-transmit-mri-in-patients-with-implanted-deep-brain-stimulation-devices
#18
Joshua Kahan, Anastasia Papadaki, Mark White, Laura Mancini, Tarek Yousry, Ludvic Zrinzo, Patricia Limousin, Marwan Hariz, Tom Foltynie, John Thornton
BACKGROUND: Deep brain stimulation (DBS) is an established treatment for patients with movement disorders. Patients receiving chronic DBS provide a unique opportunity to explore the underlying mechanisms of DBS using functional MRI. It has been shown that the main safety concern with MRI in these patients is heating at the electrode tips - which can be minimised with strict adherence to a supervised acquisition protocol using a head-transmit/receive coil at 1.5T. MRI using the body-transmit coil with a multi-channel receive head coil has a number of potential advantages including an improved signal-to-noise ratio...
2015: PloS One
https://www.readbyqxmd.com/read/26046412/motor-and-nonmotor-circuitry-activation-induced-by-subthalamic-nucleus-deep-brain-stimulation-in-patients-with-parkinson-disease-intraoperative-functional-magnetic-resonance-imaging-for-deep-brain-stimulation
#19
Emily J Knight, Paola Testini, Hoon-Ki Min, William S Gibson, Krzysztof R Gorny, Christopher P Favazza, Joel P Felmlee, Inyong Kim, Kirk M Welker, Daniel A Clayton, Bryan T Klassen, Su-youne Chang, Kendall H Lee
OBJECTIVE: To test the hypothesis suggested by previous studies that subthalamic nucleus (STN) deep brain stimulation (DBS) in patients with Parkinson disease would affect the activity of motor and nonmotor networks, we applied intraoperative functional magnetic resonance imaging (fMRI) to patients receiving DBS. PATIENTS AND METHODS: Ten patients receiving STN DBS for Parkinson disease underwent intraoperative 1.5-T fMRI during high-frequency stimulation delivered via an external pulse generator...
June 2015: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/25935723/cortico-pallidal-oscillatory-connectivity-in-patients-with-dystonia
#20
Wolf-Julian Neumann, Ashwani Jha, Antje Bock, Julius Huebl, Andreas Horn, Gerd-Helge Schneider, Tillmann H Sander, Vladimir Litvak, Andrea A Kühn
Primary dystonia has been associated with an underlying dysfunction of a wide network of brain regions including the motor cortex, basal ganglia, cerebellum, brainstem and spinal cord. Dystonia can be effectively treated by pallidal deep brain stimulation although the mechanism of this effect is not well understood. Here, we sought to characterize cortico-basal ganglia functional connectivity using a frequency-specific measure of connectivity-coherence. We recorded direct local field potentials from the human pallidum simultaneously with whole head magnetoencephalography to characterize functional connectivity in the cortico-pallidal oscillatory network in nine patients with idiopathic dystonia...
July 2015: Brain: a Journal of Neurology
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