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peg 3350 hepatic encephalopathy

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https://www.readbyqxmd.com/read/25243839/lactulose-vs-polyethylene-glycol-3350-electrolyte-solution-for-treatment-of-overt-hepatic-encephalopathy-the-help-randomized-clinical-trial
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RANDOMIZED CONTROLLED TRIAL
Robert S Rahimi, Amit G Singal, Jennifer A Cuthbert, Don C Rockey
IMPORTANCE: Hepatic encephalopathy (HE) is a common cause of hospitalization in patients with cirrhosis. Pharmacologic treatment for acute (overt) HE has remained the same for decades. OBJECTIVE: To compare polyethylene glycol 3350-electrolyte solution (PEG) and lactulose treatments in patients with cirrhosis admitted to the hospital for HE. We hypothesized that rapid catharsis of the gut using PEG may resolve HE more effectively than lactulose. DESIGN, SETTING, AND PARTICIPANTS: The HELP (Hepatic Encephalopathy: Lactulose vs Polyethylene Glycol 3350-Electrolyte Solution) study is a randomized clinical trial in an academic tertiary hospital of 50 patients with cirrhosis (of 186 screened) admitted for HE...
November 2014: JAMA Internal Medicine
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