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Rhinosinusitis treatment

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https://www.readbyqxmd.com/read/28931197/study-of-factors-responsible-for-recidivism-in-allergic-fungal-rhinosinusitis
#1
Bipin Kishore Prasad
Patients with allergic fungal rhinosinusitis (AFRS) are typically atopic and immunocompetent. Despite combined modality treatment based on surgery and immunomodulation, the potential for recidivism is well recognized. A study was conducted in a military hospital in India to identify the factors responsible for recidivism in AFRS and to suggest measures to overcome it. Sixty patients with AFRS (42 new cases and 18 cases that required revision surgery) were managed between January 2009 and July 2013. Patients underwent endoscopic, radiologic, and laboratory evaluation for AFRS followed by functional endoscopic sinus surgery...
September 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28921521/a-paradigm-for-evaluation-and-management-of-the-maxillary-sinus-before-dental-implantation
#2
Yi-Wei Chen, Fu-Ying Lee, Po-Hung Chang, Chi-Che Huang, Chia-Hsiang Fu, Chien-Chia Huang, Ta-Jen Lee
OBJECTIVES: To determine a paradigm for evaluating and managing maxillary sinus conditions before dental implantation via preoperative sinonasal assessment. STUDY DESIGN: Prospective cohort study. METHODS: Eighty-four patients who underwent dental implantation with or without sinus augmentation were included. Maxillary sinus conditions were classified into groups 1 to 6 according to cone-beam computed tomography (CT) findings: 1) nonspecific findings, 2) solitary polyp or cyst, 3) mucosal thickening, 4) air-fluid level or fluid accumulation, 5) near-total opacification of the maxillary or other paranasal sinus, and 6) calcification spots in the maxillary sinus...
September 16, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28918658/the-role-of-upper-airway-pathology-as-a-co-morbidity-in-severe-asthma
#3
Amelia Licari, Ilaria Brambilla, Maria De Filippo, Dimitri Poddighe, Riccardo Castagnoli, Gian Luigi Marseglia
Severe asthma is a complex heterogeneous disease that is refractory to standard treatment and is complicated by multiple co-morbidities and risk factors. Several co-morbidities may contribute to worsen asthma control and complicate diagnostic and therapeutic management of severe asthmatic patients. Areas covered: A prevalent cluster of chronic upper airway co-morbid diseases is recognized in severe asthma. Evaluation for these disorders should always be considered in clinical practice. The aim of this review is to provide an updated overview of the prevalence, the pathogenetic mechanisms, the clinical impact and the therapeutic options for upper airway pathology in severe asthma, focusing on chronic rhinosinusitis and allergic rhinitis...
September 16, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28918644/anti-ige-and-anti-il5-biologic-therapy-in-the-treatment-of-nasal-polyposis-a-systematic-review-and-meta-analysis
#4
Alexander Rivero, Jonathan Liang
OBJECTIVE: To determine the role of biologic therapy on sinonasal symptoms and objective outcomes in chronic rhinosinusitis with nasal polyposis (CRSwNP). METHODS: PubMed, OVID MEDLINE, and Cochrane Central were reviewed from 2000 to 2015. Inclusion criteria included English-language studies containing original data on biologic therapy in CRSwNP patients with reported outcome measures. Two investigators independently reviewed all manuscripts and performed quality assessment and quantitative meta-analysis using validated tools...
September 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28911045/azole-resistant-aspergillosis-epidemiology-molecular-mechanisms-and-treatment
#5
REVIEW
Anuradha Chowdhary, Cheshta Sharma, Jacques F Meis
Aspergillus fumigatus remains the most common species in all pulmonary syndromes, followed by Aspergillus flavus which is a common cause of allergic rhinosinusitis, postoperative aspergillosis and fungal keratitis. The manifestations of Aspergillus infections include invasive aspergillosis, chronic pulmonary aspergillosis and bronchitis. Allergic manifestations of inhaled Aspergillus include allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization. Triazoles are the mainstay of therapy against Aspergillus infections for treatment and prophylaxis...
August 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28910890/-clinical-analysis-of-orbital-complications-due-to-rhinosinusitis-in-28-cases
#6
N Li, L G Yu, M Chen, L Yang, Z R Qin, Y Jiang
Objective: To investigate the clinical characteristics of orbital complications due to rhinosinusitis and to provide the basis for the diagnosis and treatment of this disease. Methods: Retrospectively analyzed the clinical data of 28 patients with orbital complications due to rhinosinusitis who were admitted into the Affiliated Hospital of Qingdao University, Department of Otorhinolaryngology from August 2009 to April 2017. In all 28 cases, there were 1 case with preseptal cellulites, 9 cases with orbital cellulites, 13 cases with subperiosteal orbital abscess and 5 cases with orbital abscess...
September 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28901282/antihistamines-for-treating-rhinosinusitis-systematic-review-and-meta-analysis-of-randomised-controlled-studies
#7
K Seresirikachorn, L Khattiyawittayakun, W Chitsuthipakorn, K Snidvongs
BACKGROUND: Without the release of histamines, patients with rhinosinusitis may not benefit from antihistamines. Additionally, anticholinergic effects may do more harm than good. This study aimed to investigate the effectiveness of antihistamines in treating rhinosinusitis. METHODS: An electronic search was performed. Randomised controlled trials comparing antihistamines with either placebo or other treatments for patients with rhinosinusitis were selected. RESULTS: Two studies (184 patients) met the inclusion criteria...
September 13, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28895150/chemosensory-function-before-and-after-multimodal-treatment-in-chronic-rhinosinusitis-patients
#8
Ute Walliczek-Dworschak, Robert Pellegrino, Franziska Taube, Christian A Mueller, Boris Alexander Stuck, Philipp Dworschak, Christian Güldner, Silke Steinbach
OBJECTIVES/HYPOTHESIS: Olfactory dysfunction is common among the general population, with chronic rhinosinusitis (CRS) as one of the leading causes. Patients affected by CRS often report changes in taste sensations; however, quantitative measurements have not been performed to date. Therefore, the present study aimed to investigate gustatory and olfactory function in CRS patients prior to and after multimodal treatment. STUDY DESIGN: Prospective cohort study. METHODS: Twenty-one patients suffering from CRS with nasal polyps (14 male, seven female) with a mean age of 48 ± 15 years were included in the study...
September 12, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28894828/the-role-of-antibiotics-in-pediatric-chronic-rhinosinusitis
#9
REVIEW
Itzhak Brook
OBJECTIVES: Presenting the role of antibiotics in pediatric chronic rhinosinusitis based on its pathophysiology and microbiology. DATA SOURCE: Review of the literature searching PubMed for microbiology and treatment of pediatric chronic rhinosinusitis. RESULTS: Chronic rhinosinusitis (CRS) is an inflammatory condition of the paranasal sinuses that persists for 12 weeks or longer, despite medical management. The microbiology of rhinosinusitis evolves through several stages...
June 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28894821/the-role-of-infection-and-antibiotics-in-chronic-rhinosinusitis
#10
REVIEW
Miriam Baron Barshak, Marlene L Durand
OBJECTIVE: To review the current understanding of the role of infection and antibiotics in chronic rhinosinusitis. REVIEW METHODS: PubMed literature search. RESULTS: Chronic rhinosinusitis (CRS) in adults is an inflammatory condition and the role of infection is unclear. Biofilms are present in both CRS and normal patients so their role in CRS is unknown. Sinus cultures in CRS demonstrate a mixture of aerobic and anaerobic bacteria but may be hard to interpret due to contaminating nasal flora...
February 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28894808/animal-models-in-crs-and-pathophysiologic-insights-gained-a-systematic-review
#11
REVIEW
Hyun-Woo Shin
OBJECTIVE: Chronic rhinosinusitis (CRS) is a multifactorial inflammatory disease. In particular, CRS with eosinophilic features and/or nasal polyps (NPs) is often recalcitrant to current treatment; thus, appropriate animal models are mandatory to elucidate the pathogenesis of CRS and develop novel and efficient treatment modalities. The author reviewed the recently proposed animal models in CRS and discussed the pathophysiologic insights gained. Data Sources: Articles in the English language referenced in MEDLINE/PubMed from the year 2006 onward (for last 10 years)...
October 2016: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28893326/the-effects-of-nasal-lavage-with-betamethasone-cream-post-endoscopic-sinus-surgery-clinical-trial
#12
B Dawson, I Gutteridge, A Cervin, D Robinson
BACKGROUND: Steroid nasal irrigation for chronic rhinosinusitis patients following endoscopic sinus surgery reduces symptom recurrence. There are minimal safety data to recommend this treatment. This study evaluated the safety of betamethasone nasal irrigation by measuring its impact on endogenous cortisol levels. METHODS: Participants performed daily betamethasone nasal irrigation for six weeks. The impact on pre- and post-intervention serum and 24-hour urinary free cortisol was assessed...
September 12, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28892889/fungal-rhinosinusitis-microbiological-and-histopathological-perspective
#13
Ajay Kumar Singh, Prashant Gupta, Nitya Verma, Vineeta Khare, Abrar Ahamad, Virendra Verma, S P Agarwal
INTRODUCTION: On the basis of histopathology Fungal Rhinosinusitis (FRS) is categorized into non-invasive (allergic fungal rhinosinusitis, fungal ball) and invasive (acute invasive, chronic invasive and granulomatous invasive fungal sinusitis). This differentiation helps to decide the treatment. Role of latest molecular methods such as PCR and conventional methods such as KOH microscopy and culture also needs to be evaluated. Therefore, in this study we planned to categorise fungal rhinosinusitis on the basis of histopathology and compare it with other methods such as PCR, culture and KOH microscopy...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28883651/the-role-of-transcriptional-factor-p63-in-regulation-of-epithelial-barrier-and-ciliogenesis-of-human-nasal-epithelial-cells
#14
Yakuto Kaneko, Takayuki Kohno, Takuya Kakuki, Ken-Ichi Takano, Noriko Ogasawara, Ryo Miyata, Shin Kikuchi, Takumi Konno, Tsuyoshi Ohkuni, Ryoto Yajima, Akito Kakiuchi, Shin-Ichi Yokota, Tetsuo Himi, Takashi Kojima
Disruption of nasal epithelial tight junctions (TJs) and ciliary dysfunction are found in patients with chronic rhinosinusitis (CRS) and nasal polyps (NPs), along with an increase of p63-positive basal cells and histone deacetylase (HDAC) activity. To investigate these mechanisms, primary cultures of HNECs transfected with human telomerase reverse transcriptase (hTERT-HNECs) were transfected with siRNAs of TAp63 and ΔNp63, treated with the NF-kB inhibitor curucumin and inhibitors of HDACs, and infected with respiratory syncytial virus (RSV)...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28866209/the-application-of-silver-nano-particles-on-developing-potential-treatment-for-chronic-rhinosinusitis-antibacterial-action-and-cytotoxicity-effect-on-human-nasal-epithelial-cell-model
#15
Shyuan-Yow Chen, Min-Tsan Huang, Sylvia L F Pender, Muhammad Ruslin, Hsin-Hua Chou, Keng-Liang Ou
Chronic rhinosinusitis (CRS) has raised attentions both in many countries due to its high relapsing rate and the resistance of certain treatments especially antibiotics application on both acute and chronic bacterial rhinosinusitis. The aim of this research is stressing on developing an effective alternative treatment for treating CRS and reducing the use of antibiotics to avoid further resistance forming. The antibacterial functions of silver nano-particles (AgNPs) are well known according to previous reports and studies...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28865115/paving-the-future-of-rhinosinusitis-care
#16
P W Hellings
Novel insights into the pathophysiology of chronic rhinosinsusitis (CRS) will lead to endo-type driven treatment and reduce oral corticosteroid treatment.
September 1, 2017: Rhinology
https://www.readbyqxmd.com/read/28853058/pharmacological-management-of-chronic-rhinosinusitis-current-and-evolving-treatments
#17
Daniel M Beswick, Stacey T Gray, Timothy L Smith
Chronic rhinosinusitis (CRS) is an inflammatory sinonasal condition with multiple etiologic factors that is associated with a vast economic cost. Treatment is most frequently pharmacologic and has centered on agents that ameliorate inflammation, decrease bacterial or pathogen load, and facilitate egress of mucus or purulence from the sinonasal cavity. Nasal saline irrigations, topical nasal steroids, certain antibiotics, and systemic steroids have shown some efficacy in the management of CRS. Recently, biologic therapeutics that target specific inflammatory pathways associated with subsets of CRS have been developed and evaluated...
August 29, 2017: Drugs
https://www.readbyqxmd.com/read/28843029/a-retrospective-analysis-of-538-sinonasal-fungus-ball-cases-treated-at-a-single-tertiary-medical-center-in-korea-1996-2015
#18
Young Hoon Yoon, Jun Xu, Soo Kyoung Park, Jae Hyung Heo, Yong Min Kim, Ki-Sang Rha
BACKGROUND: Sinonasal fungus ball (FB) is a type of noninvasive fungal rhinosinusitis affecting immunocompetent hosts. FB, previously considered rare, has been reported with increasing frequency. We reviewed our experience of 538 cases over the past 20 years. METHODS: We retrospectively examined clinical records including clinical presentations, radiological findings, management, and outcomes of FB patients who have undergone surgery for treatment. The number of FB patients who underwent endoscopic sinus surgery (ESS) was calculated annually...
August 26, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28837619/ll-37-causes-cell-death-of-human-nasal-epithelial-cells-which-is-inhibited-with-a-synthetic-glycosaminoglycan
#19
Andrew J Thomas, Abigail Pulsipher, Brock M Davis, Jeremiah A Alt
LL-37 is an immune peptide that regulates innate and adaptive immune responses in the upper airways. Elevated levels of LL-37 have been linked to cell death and inflammatory diseases, such as chronic rhinosinusitis (CRS). Glycosaminoglycans (GAGs) are polysaccharides that are found on respiratory epithelial cells and serve important roles in mucosal surface repair. Recent findings suggest that a synthetic glycosaminoglycan (GM-0111) can protect against LL-37-induced sinonasal mucosal inflammation and cell death in a murine model of acute RS...
2017: PloS One
https://www.readbyqxmd.com/read/28828551/development-of-a-mouse-model-of-eosinophilic-chronic-rhinosinusitis-with-nasal-polyp-by-nasal-instillation-of-an-aspergillus-protease-and-ovalbumin
#20
Ho Chan Kim, Ji Youn Lim, Seoyeon Kim, Ji Heui Kim, Yong Ju Jang
One subtype of chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by the development of a T-helper type 2 (Th2) response and eosinophilic infiltration. Here, we aimed to establish an eosinophilic CRSwNP murine model, which would be essential to understand the underlying pathogenesis and establish a treatment strategy. C57BL/6 mice were challenged intranasally with a mixture of an Aspergillus oryzae-derived protease (AP) and ovalbumin (OVA) for 6, 8, or 12 consecutive weeks (12 mice/group); control mice received the same volume of phosphate-buffered saline for 12 weeks (n = 12)...
August 21, 2017: European Archives of Oto-rhino-laryngology
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