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Rhinosinusitis treatment

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https://www.readbyqxmd.com/read/29164323/safety-of-intranasal-corticosteroid-sprays-during-pregnancy-an-updated-review
#1
REVIEW
Ahmed H Alhussien, Riyadh A Alhedaithy, Saad A Alsaleh
INTRODUCTION: Rhinitis and rhinosinusitis are commonly encountered in pregnant women. Intranasal corticosteroid (INCS) sprays are generally safe and effective in the treatment of these conditions in the general population. However, the use of some of these INCS sprays during pregnancy is still controversial. OBJECTIVE: To review the current literature about the safety of intranasal corticosteroid sprays during pregnancy. METHODOLOGY: Using different search engines, each type of INCS was reviewed separately (triamcinolone, beclomethasone, budesonide, fluticasone propionate, fluticasone furoate, mometasone, and ciclesonide)...
November 21, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29154250/functional-endoscopic-sinus-surgery-fess-in-unilateral-sinus-disease
#2
Daniela Mielcarek-Kuchta, Karolina Simon, Dawid Kondratowicz, Zofia Łukomska, Aleksandra Rybak-Korytowska
BACKGROUND: Unilateral sinus disease (USD) occurs in 23 % of all cases. It is believed that it is mainly associated with cancer development. Retrospective data from large rhinological centers show that the most common USD is chronic rhinosinusitis (CRS), followed by mycosis, inverted papilloma and finally cancer, but only in a small percent of cases. THE AIM OF THE STUDY: The analysis of USD in the group of patients who underwent FESS at the secondary referral center...
October 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29133225/longitudinal-evaluation-of-chronic-rhinosinusitis-symptoms-in-a-population-based-sample
#3
Agnes S Sundaresan, Annemarie G Hirsch, Amanda J Young, Jonathan Pollak, Bruce K Tan, Robert P Schleimer, Robert C Kern, Thomas L Kennedy, J Scott Greene, Walter F Stewart, Karen Bandeen-Roche, Brian S Schwartz
BACKGROUND: Chronic rhinosinusitis (CRS) is a prevalent and disabling condition of the nose and sinuses. The natural history of CRS symptoms in a general population sample has not been previously studied. OBJECTIVE: In a general population-based sample from Pennsylvania, we used 2 questionnaires mailed 6 months apart to estimate the prevalence of, and identify predictors for, stability or change in symptoms over time. METHODS: We mailed the baseline and 6-month follow-up questionnaires to 23,700 primary care patients and 7,801 baseline responders, respectively...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29131443/a-systematic-review-of-randomized-controlled-trials-with-herbal-medicine-on-chronic-rhinosinusitis
#4
REVIEW
Majid Anushiravani, Mahdi Bakhshaee, Ali Taghipour, Hamideh Naghedi-Baghdar, Masoumeh Kaboli Farshchi, Seyed Saeed Hoseini, Mohammad Reza Mehri
Chronic rhinosinusitis (CRS) is a common disease with evidence to show that its incidence and prevalence are increasing. Medicinal plants are commonly used to treat CRS. This systematic review aimed to assess the effectiveness and safety of herbal preparations for treatment of the patients with CRS. Cochran, Embase, ISI, PubMed, and Scopus databases were searched until August 1, 2016. Only randomized controlled trials were included. Four randomized controlled trials were included in this systematic review. Various medicinal plants were studied in each article...
November 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29119837/eps-7630-is-effective-and-safe-in-children-under-6-years-with-acute-respiratory-tract-infections-clinical-studies-revisited
#5
Wolfgang Kamin, Petra Funk, Georg Seifert, Andrea Zimmermann, Walter Lehmacher
Objective - Pelargonium sidoides preparation EPs 7630 has been proven safe and effective in acute respiratory tract infections (aRTIs), but data for young children have not been presented separately. We reviewed clinical studies and present an overview of known and newly analyzed data from children <6 years. Methods - We searched MEDLINE and EMBASE for interventional and non-interventional studies which investigated the effects of EPs 7630 in aRTIs and included children <6 years of age. Subgroup analyses for this age range were performed for symptom scales, global efficacy or effectiveness assessments, and safety outcomes...
November 9, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29116046/radon-enriched-hot-spring-water-therapy-for-upper-and-lower-respiratory-tract-inflammation
#6
Desiderio Passali, Giacomo Gabelli, Giulio Cesare Passali, Ralph Mösges, Luisa Maria Bellussi
Background Radon-222-enriched hot spring therapy, which is characterized by a safe level of radioactivity, is used for the treatment of rheumatic disorders, and its efficacy has already been studied in several clinical trials. Radon-water inhalation therapy for the treatment of upper and lower airway inflammatory diseases is used in many hot springs centers. However, its application has not been reviewed to date. Methods We systematically searched the PubMed and Scopus databases for clinical trials published in the last 20 years in which objective parameters of upper and lower airway function had been tested before and after radon-enriched inhalation treatment...
August 31, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29115519/pten-promotes-apoptosis-of-h2o2%C3%A2-injured-rat-nasal-epithelial-cells-through-pi3k-akt-and-other-pathways
#7
Minghui Jia, Xiaoyun Chen, Jili Liu, Jun Chen
Chronic rhinosinusitis (CRS) is a form of chronic inflammation of the nasal cavity and paranasal sinus with multi‑causal pathogenesis, including oxidative stress. Several lines of evidence have demonstrated that the phosphatase and tensin homolog gene (PTEN) can inhibit the activation of phosphoinositide 3‑kinase (PI3K) to affect phosphorylation of Akt. Importantly, the PI3K/PTEN/Akt signaling pathway is associated with various types of tumors, chronic inflammatory diseases, and autoimmune disease through its regulation of cell growth, apoptosis, proliferation, and metabolism...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29114894/lack-of-long-term-add-on-effect-by-montelukast-in-postoperative-chronic-rhinosinusitis-patients-with-nasal-polyps
#8
Laura Van Gerven, Cristobal Langdon, Arturo Cordero, Sara Cardelús, Joaquim Mullol, Isam Alobid
OBJECTIVES/HYPOTHESIS: Eosinophils and mast cells are among the key cells in inflammatory diseases like chronic rhinosinusitis (CRS) and asthma. Leukotriene antagonists have proven to be effective in the treatment of asthma, but data about their efficacy in CRS are scarce, whereas data on montelukast as an add-on treatment to intranasal corticosteroids (INCS) in a postoperative setting are completely lacking. STUDY DESIGN: Prospective, randomized, open-label trial...
November 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29106996/chronic-rhinosinusitis-endotypes-biomarkers-and-treatment-response
#9
Jose Gurrola, Larry Borish
It is increasingly recognized that chronic rhinosinusitis (CRS) comprises a spectrum of different diseases with distinct clinical presentations and pathogenic mechanisms. Defining the distinct phenotypes and endotypes of CRS impacts prognosis and most importantly is necessary as the basis for making therapeutic decisions. The need for individualized defining of pathogenic mechanisms prior to initiating therapy extends to virtually all therapeutic considerations. This is clearly crucial with antibiotics where, barring an influence from their off-target anti-inflammatory pharmacological effects, an understanding of the role of individual biome predicts likelihood of therapeutic benefit...
October 26, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29101992/acr-appropriateness-criteria-%C3%A2-sinonasal-disease
#10
Claudia F E Kirsch, Julie Bykowski, Joseph M Aulino, Kevin L Berger, Asim F Choudhri, David B Conley, Michael D Luttrull, Diego Nunez, Lubdha M Shah, Aseem Sharma, Vilaas S Shetty, Rathan M Subramaniam, Sophia C Symko, Rebecca S Cornelius
Imaging of sinonasal pathology may occur for assessment of rhinosinusitis or mass lesions. Rhinosinusitis is prevalent in up to 16% of the US population with annual economic burdens estimated at 22 billion dollars. Rhinosinusitis is characterized as acute or chronic based on symptom duration; if four or more episodes occur annually, the term recurrent acute rhinosinusitis (RARS) is used. In acute uncomplicated rhinosinusitis when inflammatory change remains in the paranasal sinuses and nasal cavity, imaging may not be required...
November 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29099731/update-on-pediatric-sinus-surgery-indications-and-outcomes
#11
David A Gudis, Zachary M Soler
PURPOSE OF REVIEW: To review the recent literature of pediatric endoscopic sinus surgery (ESS). RECENT FINDINGS: Sinus balloon catheter dilation is an important addition to the surgical treatment tools for pediatric chronic rhinosinusitis (PCRS). ESS is a safe and effective therapeutic modality for uncomplicated PCRS. For PCRS complicated by comorbidities including cystic fibrosis and primary ciliary dyskinesia, ESS and adjuvant medical therapy confers significant sinus, pulmonary, and quality of life benefits to pediatric patients...
December 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29098299/safety-and-effectiveness-of-a-bioabsorbable-steroid-releasing-implant-for-the-paranasal-sinus-ostia-a-randomized-clinical-trial
#12
Amber Luong, Randall A Ow, Ameet Singh, Robert L Weiss, Joseph K Han, Roland Gerencer, J Pablo Stolovitzky, James W Stambaugh, Aarthi Raman
Importance: Suboptimal outcomes of endoscopic sinus surgery (ESS) are often associated with restenosis and inflammation of frontal sinus ostia. Steroid-releasing sinus implants have been shown to maintain sinus patency by minimizing inflammation and scar tissue formation. An hourglass-shaped, bioabsorbable, steroid-releasing implant was developed to provide mechanical support and optimize drug delivery to paranasal sinus ostia. Objective: To assess the safety and efficacy of the hourglass-shaped, bioabsorbable, steroid-releasing sinus implant in improving postoperative outcomes when placed in the frontal sinus ostia (FSO) following ESS in patients with chronic rhinosinusitis (CRS)...
November 2, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29094889/chronic-rhinosinusitis
#13
Ahmad R Sedaghat
Chronic rhinosinusitis is an inflammatory disease of the paranasal sinuses that occurs in 1% to 5% of the U.S. POPULATION: It may significantly decrease quality of life. Chronic rhinosinusitis is defined by the presence of at least two out of four cardinal symptoms (i.e., facial pain/pressure, hyposmia/anosmia, nasal drainage, and nasal obstruction) for at least 12 consecutive weeks, in addition to objective evidence. Objective evidence of chronic rhinosinusitis may be obtained on physical examination (anterior rhinoscopy, endoscopy) or radiography, preferably from sinus computed tomography...
October 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29084007/odontogenic-sinusitis-developments-in-diagnosis-microbiology-and-treatment
#14
Alan D Workman, Eric J Granquist, Nithin D Adappa
PURPOSE OF REVIEW: Odontogenic causes of sinusitis are frequently missed; clinicians often overlook odontogenic disease whenever examining individuals with symptomatic rhinosinusitis. Conventional treatments for chronic rhinosinusitis (CRS) will often fail in odontogenic sinusitis. There have been several recent developments in the understanding of mechanisms, diagnosis, and treatment of odontogenic sinusitis, and clinicians should be aware of these advances to best treat this patient population...
October 27, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29083530/efficacy-of-nasal-irrigation-with-200-%C3%AE-g-ml-amphotericin-b-after-functional-endoscopic-sinus-surgery-a-randomized-placebo-controlled-double-blind-study
#15
Rong-San Jiang, Chih-Wen Twu, Kai-Li Liang
BACKGROUND: Previous studies have shown controversial results of topical amphotericin B (AMB) nasal irrigation for chronic rhinosinusitis (CRS). The purpose of this study was to evaluate the efficacy of 200 μg/mL AMB nasal irrigation as an adjuvant therapy after functional endoscopic sinus surgery (FESS). METHODS: Patients with CRS who had received FESS for treatment were recruited and assigned to 1 of 2 groups at random at 1 month postsurgery. In the AMB group patients received nasal irrigation with 200 μg/mL of AMB for 2 months on a daily basis...
October 30, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29083529/evaluation-of-patient-nasal-saline-irrigation-practices-following-endoscopic-sinus-surgery
#16
Frederick Yoo, Elisabeth H Ference, Edward C Kuan, Jivianne T Lee, Marilene B Wang, Jeffrey D Suh
BACKGROUND: Functional endoscopic sinus surgery (FESS) is an effective treatment for chronic rhinosinusitis (CRS). Postoperative management strategies after FESS often vary from surgeon to surgeon. Recent data suggests that nasal saline irrigation following FESS is almost universally recommended; however, patient adherence has not been formally evaluated. The purpose of this study is to evaluate postoperative nasal irrigation practices and its effects on short-term outcomes in post-FESS patients...
October 30, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29081260/diagnostic-significance-of-serum-periostin-in-eosinophilic-chronic-sinusitis-with-nasal-polyps
#17
Ming Xu, Weiwei Zhang, Daishi Chen, Haojie Zhou, Lei Chen
OBJECTIVES: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease. Eosinophilic CRSwNP (ENP) exhibits a strong tendency for recurrence after surgery. Given that the treatment strategy of ENP differs from that of non-eosinophilic CRSwNP (nENP), clinical diagnostic criteria that distinguish ENP from nENP are needed. METHODS: In total, 94 CRSwNP patients were enrolled in the cohort. Factors associated with ENP were determined with regression analysis, and optimal cutoff points of the predictors were determined by a receiver operating characteristic curve...
October 28, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29072660/-the-role-of-a-leukotriene-receptor-antagonist-in-the-restoration-of-the-nasal-breathing-in-the-patients-presenting-with-polypous-rhinosinusitis
#18
T A Mashkova, A B Mal'tsev, A I Nerovny, L S Bakulina
The present study was designed to investigate the clinical. laboratory, and morphological characteristics of the nasal obstruction process. It included 87 patients presenting with polypous rhinosinusitis. The dynamics of the serum leukotriene C4 (LTC4) level in the patients and the morphological changes in their polypous tissue suggested the existence of the pronounced exudative phase of allergic inflammation and provided a basis for the use of the leukotriene receptor antagonist in the form of the sodium montelucast tablets for the treatment of nasal obstruction...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29055085/current-use-of-baseline-medical-treatment-in-chronic-rhinosinusitis-data-from-the-national-chronic-rhinosinusitis-epidemiology-study-cres
#19
Carl Philpott, Sally Erskine, Rupert Smith, Claire Hopkins, Naveed Kara, Amir Farboud, Mahmoud Salam, Alasdair Robertson, Rob Almeyda, B Nirmal Kumar, Shahram Anari, Jaydip Ray, Russell Cathcart, Sean Carrie, Shahzada Ahmed, Hisham Khalil, Allan Clark, Mike Thomas
OBJECTIVES: According to clinical and comissioning guidelines for chronic rhinosinusitis (CRS), patients being referred to secondary care should have failed primary medical treatment with nasal douching (ND) and intranasal corticosteroids (INCS). The study objectives were to identify the rate of specific medical therapy in CRS patients and establish any differences in medication use, for both CRS and associated medical conditions, between CRS phenotypes. DESIGN AND SETTING: Case-control study in a secondary care setting...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29054113/post-operative-corticosteroid-irrigation-for-chronic-rhinosinusitis-after-endoscopic-sinus-surgery-a-meta-analysis
#20
Ho Young Yoon, Ho Seok Lee, In Hye Kim, Se Hwan Hwang
BACKGROUND: Recently, topical steroid therapy delivery using high-volume sinonasal irrigations has been used more frequently, following endoscopic sinus surgery (ESS), to improve drug delivery into the paranasal sinuses. OBJECTIVE: The goal of this study was to perform a systematic review with meta-analysis of the efficacy of steroid nasal irrigation on postoperative management of CRS following ESS. METHODS: Five databases (PubMed, SCOPUS, Embase, Web of Science, and the Cochrane database) from inception to March 2017 were independently reviewed by two researchers...
October 20, 2017: Clinical Otolaryngology
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