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Rhinosinusitis treatment

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https://www.readbyqxmd.com/read/28806502/efficacy-of-endoscopic-sinus-surgery-for-chronic-rhinosinusitis-following-primary-radiotherapy-and-concurrent-chemotherapy-for-nasopharyngeal-carcinoma
#1
Noel Ayoub, Evan Walgama, Andrew Thamboo, Jayakar V Nayak, Peter H Hwang
BACKGROUND: Chronic rhinosinusitis (CRS) is a downstream complication following radiotherapy or chemoradiation for nasopharyngeal carcinoma (NPC). Endoscopic sinus surgery (ESS) is an accepted therapy for medically refractory CRS, but its efficacy in addressing CRS symptoms in patients with previously irradiated NPC is unclear. METHODS: All patients at the Stanford Sinus Center with a history of radiation therapy or chemoradiation for NPC between 2006 and 2015 were reviewed...
August 14, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28802373/clinical-curative-effect-and-safety-of-balloon-sinuplasty-in-children-with-chronic-rhinosinusitis
#2
Jia Liu, Zigai Zhao, Yang Chen, Bin Xu, Jiren Dai, Yong Fu
OBJECTIVE: Balloon Sinuplasty for the management of paranasal sinus inflammatory diseases was introduced in otolaryngology in 2005. Over the past decade, evidence strongly supports its safety and efficacy for the treatment of chronic rhinosinusitis (CRS) in adults. Because it requires no bone or tissue removal, this procedure could be suitable in children. We present our initial experience of its use for the treatment of CRS in children. MATERIALS AND METHODS: A prospective study was performed of 30 children with failed medical therapy, who were scheduled for surgery...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28776718/analysis-of-factors-associated-with-electing-endoscopic-sinus-surgery
#3
Adam S DeConde, Jess C Mace, Vijay R Ramakrishnan, Jeremiah A Alt, Timothy L Smith
OBJECTIVE: Medically refractory chronic rhinosinusitis (CRS) can be managed with appropriate continued medical therapy (CMT) or surgery followed by CMT. Patients who initially elect CMT and do not experience adequate symptom resolution may "cross over" to endoscopic sinus surgery (ESS). Our objective was to identify patient covariates associated with this subset of patients who elect this change in treatment modality. STUDY DESIGN: Retrospective analysis of a prospective, multi-center cohort of adult patients with CRS enrolled between March 2011 and June 2015 in academic, tertiary referral clinics...
August 4, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28774699/pulmonary-and-sinus-fungal-diseases-in-non-immunocompromised-patients
#4
REVIEW
David W Denning, Arunaloke Chakrabarti
The human respiratory tract is exposed daily to airborne fungi, fungal enzymes, and secondary metabolites. The endemic fungi Histoplasma capsulatum, Coccidioides spp, Blastomyces dermatitidis, and Paracoccidioides brasiliensis, and occasionally Aspergillus fumigatus, are primary pulmonary pathogens of otherwise healthy people. Such infections resolve in most people, and only a few infections lead to disease. However, many fungi are directly allergenic by colonising the respiratory tract or indirectly through contact with cell wall constituents and proteases, causing or exacerbating allergic disease...
July 31, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28770480/how-to-assess-control-and-manage-uncontrolled-crs-nasal-polyp-patients
#5
REVIEW
Rahuram Sivasubramaniam, Richard J Harvey
PURPOSE OF REVIEW: Chronic rhinosinusitis (CRS) is a multidimensional inflammatory disorder of the nose and paranasal sinuses. We reviewed the recent literature to identify improved methods to assess, control, and manage these difficult to control patients. RECENT FINDINGS: The role of endotyping in CRS has offered a better understanding of the underlying pathophysiology and allows for more targeted treatment. The understanding of systemic disorders and their role in CRS and the importance of topical treatment reaching the sinuses has also allowed for better control of these patients...
September 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28766959/pediatric-chronic-rhinosinusitis-management-in-rhinologists-and-pediatric-otolaryngologists
#6
Daniel M Beswick, Anna H Messner, Peter H Hwang
OBJECTIVE: To compare the management of pediatric chronic rhinosinusitis (PCRS) between members of the American Rhinologic Society (ARS) and the American Society of Pediatric Otolaryngology (ASPO). STUDY DESIGN: Comparison of surveys. METHODS: A web-based survey was distributed to ASPO membership twice in September-October 2016. Data were compared to previously published data from ARS membership in March-April 2016. RESULTS: ASPO survey completion rate was 22%...
August 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28766436/how-to-perform-nasal-douching
#7
Janette Bartle, Alexander Millington
Rationale and key points This article provides information on nasal douching, which nurses can use to advise patients on how to perform this procedure. It explains how to prepare and use a home-made solution for nasal douching, and discusses the various products available that can assist patients in undertaking this procedure. » Nasal douching, also known as nasal washout, irrigation or lavage, is recommended to clear mucus and allergens from the nose for people with rhinitis or rhinosinusitis. It is also recommended following nasal surgery to cleanse and aid healing inside the nose...
August 2, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28751488/guideline-recommendations-and-antimicrobial-resistance-the-need-for-a-change
#8
Christelle Elias, Lorenzo Moja, Dominik Mertz, Mark Loeb, Gilles Forte, Nicola Magrini
OBJECTIVES: Antimicrobial resistance has become a global burden for which inappropriate antimicrobial use is an important contributing factor. Any decisions on the selection of antibiotics use should consider their effects on antimicrobial resistance. The objective of this study was to assess the extent to which antibiotic prescribing guidelines have considered resistance patterns when making recommendations for five highly prevalent infectious syndromes. DESIGN: We used Medline searches complemented with extensive use of Web engine to identify guidelines on empirical treatment of community-acquired pneumonia, urinary tract infections, acute otitis media, rhinosinusitis and pharyngitis...
July 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/28750020/antibiotic-prescriptions-for-outpatient-acute-rhinosinusitis-in-canada-2007-2013
#9
Prateek Sharma, Rita Finley, Scott Weese, Shiona Glass-Kaastra, Warren McIsaac
INTRODUCTION: Acute rhinosinusitis (ARS) is a respiratory disease commonly caused by viral infections. Physicians regularly prescribe antibiotics despite bacterial etiologies being uncommon. This is of concern, as this use adds to the selection pressure for resistance. Here we present the descriptive epidemiology of acute rhinosinusitis and corresponding antibiotic prescribing practices by Canadian outpatient physicians from 2007-2013. MATERIALS/METHODS: Diagnosis and antibiotic prescription data for ARS were extracted from the Canadian Disease and Therapeutic Index for 2007 to 2013, and population data were acquired from Statistics Canada...
2017: PloS One
https://www.readbyqxmd.com/read/28745925/clinical-care-of-children-with-primary-ciliary-dyskinesia
#10
Jane S Lucas, Mikkel Christian Alanin, Samuel Collins, Amanda Harris, Helle Krogh Johansen, Kim G Nielsen, Jean Francois Papon, Phil Robinson, Woolf T Walker
Primary ciliary dyskinesia (PCD) is a rare heterogeneous disorder, usually inherited as an autosomal recessive condition but X-linked inheritance is also described. Abnormal ciliary function in childhood leads to neonatal respiratory distress in term infants, persistent wet cough, bronchiectasis, chronic rhinosinusitis, and hearing impairment; approximately 50% of patients have situs inversus. There is a paucity of evidence for treating PCD, hence consensus guidelines are predominantly influenced by knowledge from cystic fibrosis (CF)...
July 26, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28725520/mucosal-thickening-occurs-in-contralateral-paranasal-sinuses-following-sinonasal-malignancy-treatment
#11
Alice Z Maxfield, Kyle J Chambers, Ahmad R Sedaghat, Derrick T Lin, Stacey T Gray
Objective  To investigate the incidence and degree of contralateral sinus disease following treatment of sinonasal malignancy (SNM) using radiological findings as an outcome measure. Study Design  Retrospective case series. Setting  Tertiary referral academic center. Participants  Patients with SNM treated with surgical and adjuvant radiotherapy with or without concurrent chemotherapy. Main Outcome Measures  Pre- and posttreatment computed tomography and magnetic resonance imaging scans, Lund-Mackay (LM) score, date of diagnosis, chemotherapy, and dosage of radiation therapy (RT)...
August 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28718590/-novelties-in-ent-2016
#12
Francis Marchal
These novelties in ENT were selected among more than 15'000 abstracts in the 2016 literature, and dedicated to the practioner Guidelines of the American Academy of ORL will resume the attitude towards chronic otitis media, and reviews of hearing impairment and tinnitus are presented, as well as impact of the pneumoccal vaccine on otitis media. In rhinology, the flora of chronic rhinosinusitis and its non surgical treatments will be discussed, as well as epistaxis and malignant tumor series. 17 Diseases dignanosed only with exhaled air will be also reported...
March 8, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28716179/surgical-treatment-of-chronic-rhinosinusitis-after-sinus-lift
#13
Nicole Tin-Lok Jiam, Andrew N Goldberg, Andrew H Murr, Steven D Pletcher
BACKGROUND: The sinus lift (or sinus augmentation) is a common procedure to improve maxillary bone stock before dental implantation. Chronic rhinosinusitis (CRS) is a potential complication of this procedure and may be refractory to medical treatment. Functional endoscopic sinus surgery has previously been used to address CRS, however, results of previous studies indicated that implant removal is required. There are limited follow-up data available. OBJECTIVE: The purpose of this study was to characterize the long-term outcomes and efficacy of endoscopic sinus surgery for refractory CRS after sinus lift, including the ability to salvage dental implants...
July 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28716178/short-term-morbidity-after-the-endoscopic-modified-lothrop-draf-iii-procedure-compared-with-draf-iia
#14
Aria Jafari, Kathryn R Tringale, Bharat A Panuganti, Joseph R Acevedo, John Pang, Adam S DeConde
BACKGROUND: The endoscopic modified Lothrop (Draf-III) surgery has improved treatment of recalcitrant frontal sinus disease, with favorable safety and long-term results. However, the short-term clinical and quality-of-life morbidity after Draf-III relative to less-extensive procedures has yet to be investigated. OBJECTIVE: To evaluate the surgical and quality-of-life outcomes, including the burden of follow-up care, in patients who underwent endoscopic modified Lothrop (Draf-III), and compared these results with a less-extensive intervention, the endoscopic frontal sinusotomy (Draf-IIa)...
July 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28716171/the-personal-financial-burden-of-chronic-rhinosinusitis-a-canadian-perspective
#15
Jonathan Yip, Allan D Vescan, Ian J Witterick, Eric Monteiro
BACKGROUND: Previous studies describe the financial burden of chronic rhinosinusitis (CRS) from the perspective of third-party payers, but, to our knowledge, none analyze the costs borne by patients (i.e., out-of-pocket expenses [OOPE]). Furthermore, this burden has not been previously investigated in the context of a publicly funded health care system. OBJECTIVE: The purpose of this study was to characterize the financial impact of CRS on patients, specifically by evaluating its associated OOPEs and the perceived financial burden...
July 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28706720/endotype-driven-treatment-in-chronic-upper-airway-diseases
#16
REVIEW
Glynnis De Greve, Peter W Hellings, Wytske J Fokkens, Benoit Pugin, Brecht Steelant, Sven F Seys
Rhinitis and rhinosinusitis are the two major clinical entities of chronic upper airway disease. Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) affect respectively up to 10 and 30% of the total population, hence being associated with an important socio-economic burden. Different phenotypes of rhinitis and CRS have been described based on symptom severity and duration, atopy status, level of control, comorbidities and presence or absence of nasal polyps in CRS. The underlying pathophysiological mechanisms are diverse, with different, and sometimes overlapping, endotypes being recognized...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28696280/nontypeable-haemophilus-influenzae-releases-dna-and-dnabii-proteins-via-a-t4ss-like-complex-and-come-of-the-type-iv-pilus-machinery
#17
Joseph A Jurcisek, Kenneth L Brockman, Laura A Novotny, Steven D Goodman, Lauren O Bakaletz
Biofilms formed by nontypeable Haemophilus influenzae (NTHI) are central to the chronicity, recurrence, and resistance to treatment of multiple human respiratory tract diseases including otitis media, chronic rhinosinusitis, and exacerbations of both cystic fibrosis and chronic obstructive pulmonary disease. Extracellular DNA (eDNA) and associated DNABII proteins are essential to the overall architecture and structural integrity of biofilms formed by NTHI and all other bacterial pathogens tested to date. Although cell lysis and outer-membrane vesicle extrusion are possible means by which these canonically intracellular components might be released into the extracellular environment for incorporation into the biofilm matrix, we hypothesized that NTHI additionally used a mechanism of active DNA release...
July 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28687814/the-persistence-of-intracellular-staphylococcus-aureus-in-the-sinuses-a-longitudinal-study
#18
J Ou, A Bassiouni, A Drilling, A J Psaltis, S Vreugde, P J Wormald
BACKGROUND: Staphylococcus aureus (S. aureus) can reside within the sinonasal mucosa in chronic rhinosinusitis patients and causes recurrent infections. Within the host cell, S. aureus can evade host immune detection enabling its own survival. We hypothesise that S. aureus can persist within the sinonasal epithelium for a prolonged period without immune activation. METHODOLOGY: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) undergoing two sinus surgeries were included...
July 8, 2017: Rhinology
https://www.readbyqxmd.com/read/28658521/the-in-vitro-mucolytic-effect-of-xylitol-and-dornase-alfa-on-chronic-rhinosinusitis-mucus
#19
Tim Hardcastle, Ravi Jain, Fiona Radcliff, Sharon Waldvogel-Thurlow, Melissa Zoing, Kristi Biswas, Richard Douglas
BACKGROUND: The overproduction and stagnation of purulent mucus impair mucociliary clearance and exacerbate the symptoms of chronic rhinosinusitis (CRS). There is a clinical need for effective topical mucolytic agents to facilitate removal of mucus and improve postoperative outcomes. METHODS: The effects of xylitol (5%) and dornase alfa (1 mg/mL) on mucus and mucus crusts were investigated. Viscoelasticity and viscosity of wet mucus derived from 30 CRS patients was measured with a plate rheometer...
June 28, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28652944/extranodal-natural-killer-t-cell-lymphoma-an-incidental-finding
#20
Ashley Althoff, Michael Bibliowicz
Extranodal natural killer/T-cell lymphoma (ENKTCL) is a rare form of non-Hodgkin lymphoma. This neoplasm is more prevalent in regions of Asia and Latin America and most commonly involves the sinonasal tract, presenting with signs of nasal obstruction, epistaxis, or sinus infection. It is a locally destructive and angioinvasive neoplasm. The treatment of ENKTCL is dependent on the extent of the tumor. For localized disease, the treatment is chemoradiation. For disseminated disease, treatment is mainly chemotherapy-based...
May 19, 2017: Curēus
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