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https://www.readbyqxmd.com/read/29150096/flexible-roles-for-proteoglycan-sulfation-and-receptor-signaling
#1
REVIEW
Panpan Yu, Craig S Pearson, Herbert M Geller
Proteoglycans (PGs) in the extracellular matrix (ECM) play vital roles in axon growth and navigation, plasticity, and regeneration of injured neurons. Different classes of PGs may support or inhibit cell growth, and their functions are determined in part by highly specific structural features. Among these, the pattern of sulfation on the PG sugar chains is a paramount determinant of a diverse and flexible set of outcomes. Recent studies of PG sulfation illustrate the challenges of attributing biological actions to specific sulfation patterns, and suggest ways in which highly similar molecules may exert opposing effects on neurons...
November 14, 2017: Trends in Neurosciences
https://www.readbyqxmd.com/read/29143878/sensitive-mass-spectrometric-assay-for-determination-of-15-deoxy-%C3%AE-12-14-prostaglandin-j2-and-its-application-in-human-plasma-samples-of-patients-with-diabetes
#2
Jakob Morgenstern, Thomas Fleming, Ivelina Kadiyska, Sebastian Brings, Jan Benedikt Groener, Peter Nawroth, Markus Hecker, Maik Brune
The determination of individual prostaglandins (PG) in humans is mainly performed in urine samples. The quantification of PGs in human plasma could improve the understanding of particular PG species under various physiological and pathological conditions. 15-Deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) is a dehydrated downstream product of PGD2 and is of high interest due to its recently discovered anti-inflammatory effects. Increasing availability of highly sensitive mass spectrometry allows the quantification of low abundant biomarkers like 15d-PGJ2 in human plasma samples...
November 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29142843/intraoperative-real-time-localization-of-parathyroid-gland-with-near-infrared-fluorescence-imaging
#3
REVIEW
Sung Won Kim, Hyoung Shin Lee, Kang Dae Lee
Surgeons have cited difficulties in identifying the parathyroid glands (PG) during thyroidectomy. To overcome the limitation of naked eye, many studies on near-infrared fluorescence imaging of PGs have been introduced and suggested that fluorescence imaging is useful for both localizing PGs and evaluating their function. This imaging technique has been reported in two ways: (I) imaging using a fluorescent material called indocyanine green (ICG); and (II) autofluorescence using intrinsic fluorophores. These innovative and novel techniques are expected to have a significant impact on performing thyroid or parathyroid surgery...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29136603/prolonged-grief-reactions-after-old-age-spousal-loss-and-centrality-of-the-loss-in-post-loss-identity
#4
Lena Eckholdt, Lynn Watson, Maja O'Connor
BACKGROUND: The loss of a spouse is a major life event. Previous research found that centrality of the loss to one's identity using Centrality of Event Scale (CES) is related to complicated bereavement reactions, such as depression, posttraumatic stress symptoms (PTS), and prolonged grief symptoms (PGS). This study aims to examine loss-centrality in elderly bereaved people up to 4 years post loss, to determine the relation of loss-centrality to complicated bereavement reactions, such as PGS, depression, and PTS, and to identify early predictors of loss-centrality...
November 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29136266/prostanoids-and-hair-follicles-implications-for-therapy-of-hair-disorders
#5
Xue-Gang Xu, Hong-Duo Chen
Prostanoids, including prostaglandins (PGs) and thromboxane A2 (TXA2), are a family of lipid-derived autacoids that modulate many physiological systems and pathological contexts. Prostanoids are generated by sequential metabolism of arachidonic acid, catalysed by cyclo-oxygenase, to PGH2, which is then converted to PGD2, PGE2, PGF2α, PGI2 and TXA2, catalysed by their specific synthases. Recent evidence suggests that prostanoids play a role in regulating hair growth. The PGF2α analogue is Food and Drug Administration-approved and routinely used to enhance the growth of human eyelashes...
November 14, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29136227/developmental-outcome-of-9-year-old-children-born-after-pgs-follow-up-of-a-randomized-trial
#6
Derk Kuiper, Anne Bennema, Sacha la Bastide-van Gemert, Jorien Seggers, Pamela Schendelaar, Sebastiaan Mastenbroek, Annemieke Hoek, Maas Jan Heineman, Tessa J Roseboom, Joke H Kok, Mijna Hadders-Algra
STUDY QUESTION: Does Day-3 cleavage-stage PGS affect neurodevelopment of 9-year-old IVF offspring? SUMMARY ANSWER: We did not find evidence of adverse consequences of Day-3 cleavage-stage PGS on neurodevelopment of 9-year-old IVF offspring, although children born after IVF with or without PGS often had a non-optimal neurological condition. WHAT IS KNOWN ALREADY: Knowledge on long-term sequelae for development and health of children born following PGS is lacking...
November 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29135816/dopaminergic-genetic-variants-and-voluntary-externally-paced-exercise-behavior
#7
Denise J van der Mee, Iryna O Fedko, Jouke-Jan Hottenga, Erik A Ehli, Matthijs D van der Zee, Lannie Ligthart, Toos C E M van Beijsterveldt, Gareth E Davies, Meike Bartels, Joseph G Landers, Eco J C de Geus
PURPOSE: Most candidate gene studies on the neurobiology of voluntary exercise behavior have focused on the dopaminergic signaling pathway and its role in the mesolimbic reward system. We hypothesized that dopaminergic candidate genes may influence exercise behavior through additional effects on executive functioning and that these effects are only detected when the types of exercise activity are taken into account. METHODS: Data on voluntary exercise behavior and at least one SNP/VNTR were available for 12,929 participants of the Netherlands Twin Registry...
November 9, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29131268/correlation-of-insulin-like-growth-factor-1-and-osteoarthritic-cartilage-degradation-a-spontaneous-osteoarthritis-in-guinea-pig
#8
F-Y Wei, J K Lee, L Wei, F Qu, J-Z Zhang
OBJECTIVE: The pathogenesis of osteoarthritis centers on the imbalance between catabolic and anabolic processes in cartilage metabolism. Insulin growth factor 1 (IGF-1) has been shown to have anabolic effects in cartilage in vitro. This study aim to determine whether IGF-1 on cartilage is associated with loss of chondrocyte and extracellular matrix breakdown using the Hartley guinea pig model. MATERIALS AND METHODS: Cartilage from the medial and lateral tibial plateau of 6-month and 12-month old Hartley guinea pigs were used for this study...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29117384/eshre-pgd-consortium-data-collection-xiv-xv-cycles-from-january-2011-to-december-2012-with-pregnancy-follow-up-to-october-2013
#9
M De Rycke, V Goossens, G Kokkali, M Meijer-Hoogeveen, E Coonen, C Moutou
STUDY QUESTION: How does the data collection XIV-XV of the European Society of Human Reproduction and Embryology (ESHRE) PGD Consortium compare with the cumulative data for data collections I-XIII? SUMMARY ANSWER: The 14th and 15th retrospective collection represents valuable data on PGD/PGS cycles, pregnancies and children: the main trend observed is the increased application of array technology at the cost of FISH testing in PGS cycles and in PGD cycles for chromosomal abnormalities...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29117383/assisted-reproductive-technology-in-europe-2013-results-generated-from-european-registers-by-eshre
#10
C Calhaz-Jorge, C De Geyter, M S Kupka, J de Mouzon, K Erb, E Mocanu, T Motrenko, G Scaravelli, C Wyns, V Goossens
STUDY QUESTION: Are there any changes in the treatments involving ART and IUI initiated in Europe during 2013 compared with previous years? SUMMARY ANSWER: An increase in the overall number of ART cycles resulting from a higher number of countries reporting data was evident, the pregnancy rates (PRs) in 2013 remained stable compared with those reported in 2012, the number of transfers with multiple embryos (3+) was lower than ever before yet the multiple delivery rates (DRs) remained unchanged, and IUI activity and success rates were similar to those of last years...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29116283/synthesis-of-a-library-of-variously-modified-4-methylumbelliferyl-xylosides-and-a-structure-activity-study-of-human-%C3%AE-4galt7
#11
Samir Dahbi, Jean-Claude Jacquinet, Isabelle Bertin-Jung, Anne Robert, Nick Ramalanjaona, Sandrine Gulberti, Sylvie Fournel-Gigleux, Chrystel Lopin-Bon
Proteoglycans (PGs) are complex macromolecules that are composed of glycosaminoglycan (GAG) chains covalently attached to a core protein through a tetrasaccharide linker. The biosynthesis of PGs is complex and involves a large number of glycosyltranferases. Here we present a structure-activity study of human β4GalT7, which transfers the first Gal residue onto a xyloside moiety of the linkage region. An efficient and regiocontrolled synthesis of a library of modified analogs of 4-methylumbelliferyl xyloside (XylMU) is reported herein...
November 8, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29111696/sequencing-the-dermatan-sulfate-chain-of-decorin
#12
Yanlei Yu, Jiana Duan, Franklin E Leach, Toshihiko Toida, Kyohei Higashi, Hong Zhang, Fuming Zhang, I Jonathan Amster, Robert J Linhardt
Glycomics represents one of the last frontiers and most challenging in omic analysis. Glycosylation occurs in the endoplasmic reticulum and the Golgi organelle and its control is neither well-understood nor predictable based on proteomic or genomic analysis. One of the most structurally complex classes of glycoconjugates is the proteoglycans (PGs) and their glycosaminoglycan (GAG) side chains. Previously, our laboratory solved the structure of the chondroitin sulfate chain of the bikunin PG. The current study examines the much more complex structure of the dermatan sulfate GAG chain of decorin PG...
November 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29107246/the-inhibition-of-myometrial-contractions-by-chlorinated-herbicides-atrazine-and-linuron-and-their-disruptive-effect-on-the-secretory-functions-of-uterine-and-ovarian-cells-in-cow-in-vitro
#13
Michał H Wrobel, Jaroslaw Mlynarczuk
The effect of atrazine and linuron, the popular and widely used chlorinated herbicides, on both myometrial contractions and secretory functions of bovine uterus and ovaries in vitro, was investigated. The pesticides inhibited (P<0.05) the basal and oxytocin (OT)-stimulated myometrial strips contractions, as well as the effect of OT on secretion of prostaglandins (PGs: PGF2α and PGE2) from endometrium. But only linuron inhibits the effect of OT on myometrial contractions. Neither of herbicides affected PGs secretion from myometrium and PGF2α from endometrium...
October 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29102912/preparation-of-a-novel-carboxylate-rich-palygorskite-as-an-adsorbent-for-ce-3-from-aqueous-solution
#14
Jindong Chen, Wenjun Luo, Aifeng Guo, Tiantian Luo, Chao Lin, Haifeng Li, Luru Jing
A novel nanoscale adsorbing material, palygorskite (PGS) grafted polymethacrylic acid (PMAA) (PGS-g-PMAA), was successfully synthesized via atom-transfer radical-polymerization (ATRP). The grafting reaction was completed through a heterogeneous reaction in aqueous phase at normal temperature. Ce(3+) was employed as a model to systematically investigate its adsorption performance. Meanwhile, the palygorskite was characterized by X-ray diffraction (XRD), Thermogravimetric Analysis (TGA), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscope (SEM)...
October 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29100902/effect-of-estrogen-on-prostaglandin-synthetase-in-bovine-oviduct-smooth-muscle
#15
Na Huang, Caiyun Wang, Nan Zhang, Wei Mao, Bo Liu, Yuan Shen, Yu Gao, Yi Zhao, Jinshan Cao
Gamete and embryo transport is an important function of the oviduct. This type of transport involves both smooth muscle contraction and epithelial cell secretions, and the former is mediated by prostaglandins (PGs) and their receptors. Our objective was to study the regulation of prostaglandin synthetase (prostaglandin-endoperoxide synthase-1 (PTGS1), prostaglandin-endoperoxide synthase-2 (PTGS2), mPGES-1, mPGES-2, cPGES, and PGFS) by estradiol (E2) in bovine oviduct smooth muscle. Prostaglandin synthetase mRNA and protein expression were investigated using real-time RT-PCR and Western blot analyses, respectively...
October 31, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29095266/carbon-nanoparticles-facilitate-lymph-nodes-dissection-and-parathyroid-glands-identification-in-reoperation-of-papillary-thyroid-cancer
#16
An-Ping Su, Bin Wang, Yan-Ping Gong, Wen-Shuang Wu, Ri-Xiang Gong, Zhi-Hui Li, Jing-Qiang Zhu
The aim of the study was to investigate whether carbon nanoparticles (CNs) can improve the dissection of lymph nodes and protect parathyroid glands (PGs) during reoperation for patients with papillary thyroid carcinoma (PTC).PTC patients who previously underwent thyroidectomy and later received reoperation between January 2009 and January 2016 were retrospectively recruited. We compared the patients who had CN suspension injected into the residual thyroid gland with a control group of patients who did not have the injection...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29080968/sex-selection-for-non-medical-indications-a-survey-of-current-pre-implantation-genetic-screening-practices-among-u-s-art-clinics
#17
Sarah M Capelouto, Sydney R Archer, Jerrine R Morris, Jennifer F Kawwass, Heather S Hipp
PURPOSE: This study aimed to determine the current percentage of United States (U.S.) assisted reproductive technology (ART) clinics offering sex selection via pre-implantation genetic screening (PGS) for non-medical purposes. METHODS: The authors conducted website review and telephone interview survey of 493 U.S. ART clinics performing in vitro fertilization (IVF) in 2017. Main outcome measures were pre-implantation genetic screening (PGS)/pre-implantation genetic diagnosis (PGD) practices and non-medical sex selection practices including family balancing...
October 28, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29080967/is-mitochondrial-dna-quantitation-in-blastocyst-trophectoderm-cells-predictive-of-developmental-competence-and-outcome-in-clinical-ivf
#18
REVIEW
Manuel Viotti, Andrea R Victor, Christo G Zouves, Frank L Barnes
Behind every successful IVF embryo transfer, there is a great game of chance. Methods seeking to tilt the balance and increase the likelihood of implantation have been proposed and implemented with varying results, including embryo morphology, FISH-PGS, comprehensive chromosomal screening (CCS), morphokinetics, endometrial receptivity testing. It has been suggested that mitochondrial DNA (mtDNA) copy number could serve as a biomarker for embryo viability, but this concept was recently challenged. The world of IVF is left with unanswered questions: Why are there discrepancies in the reports? Should mtDNA copy number be considered to rank embryos for transfer? And in a broader sense, how well must a technique be validated before its implementation in the IVF clinic? Here, we explore these questions attempting to piece together the published data and suggest future directions to help unravel the subject matter...
October 28, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29075343/efficacy-and-safety-of-cerebrolysin-treatment-in-early-recovery-after-acute-ischemic-stroke-a-randomized-placebo-controlled-double-blinded-multicenter-clinical-trial
#19
K Gharagozli, A A Harandi, S Houshmand, N Akbari, D F Muresanu, J Vester, S Winter, H Moessler
Background and Purpose : The aim of this study was to evaluate the efficacy, safety, and tolerability of cerebrolysin in the early recovery phase after acute ischemic stroke. Methods. This prospective, randomized, double-blinded, placebo-controlled, multicenter, parallel-group study enrolled a total of 100 patients within 18 h after the onset of stroke. The patients were treated with Cerebrolysin (30 mL over seven days followed by 10 mL until day 30) or placebo once daily over a period of four weeks. Efficacy was primarily assessed by the NIH Stroke Scale at day 30, and additional parameters included the modified Rankin Scale, the Clinical Global Impression, the Patient Global Satisfaction (PGS) and the Mini Mental State Examination (MMSE)...
July 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29063503/are-blastocyst-aneuploidy-rates-different-between-fertile-and-infertile-populations
#20
Jonathan D Kort, Rajiv C McCoy, Zach Demko, Ruth B Lathi
PURPOSE: This study aimed to determine if patients with infertility or recurrent pregnancy loss have higher rates of embryo aneuploidy than fertile controls. METHODS: This was a retrospective review of all pre-implantation genetic screening (PGS) cases processed by a single reference lab prior to March 2014 after a blastocyst biopsy. Cases were excluded if no indication for PGS was designated or patients were translocation carriers. The fertile control group consisted of patients undergoing IVF with PGS for sex selection only...
October 23, 2017: Journal of Assisted Reproduction and Genetics
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