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https://www.readbyqxmd.com/read/28160379/spearmint-r2r3-myb-transcription-factor-msmyb-negatively-regulates-monoterpene-production-and-suppresses-the-expression-of-geranyl-diphosphate-synthase-large-subunit-msgpps-lsu
#1
Vaishnavi Amarr Reddy, Qian Wang, Niha Dhar, Nadimuthu Kumar, Prasanna Nori Venkatesh, Chakravarthy Rajan, Deepa Panicker, Vishweshwaran Sridhar, Hui-Zhu Mao, Rajani Sarojam
Many aromatic plants, such as spearmint, produce valuable essential oils in specialized structures called peltate glandular trichomes (PGTs). Understanding the regulatory mechanisms behind the production of these important secondary metabolites will help design new approaches to engineer them. Here, we identified a PGT-specific R2R3-MYB gene, MsMYB, from comparative RNA-Seq data of spearmint and functionally characterized it. Analysis of MsMYB-RNAi transgenic lines showed increased levels of monoterpenes, and MsMYB-overexpressing lines exhibited decreased levels of monoterpenes...
February 3, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28117899/benefits-of-a-psychodynamic-group-therapy-pgt-model-for-treating-veterans-with-ptsd
#2
Ofir Levi, Yael Shoval-Zuckerman, Eyal Fruchter, Arie Bibi, Yair Bar-Haim, Ilan Wald
OBJECTIVE: To examine the effectiveness of a treatment model of psychodynamic group therapy (PGT) for combat Veterans with posttraumatic stress disorder (PTSD). METHOD: A total of 158 male Veterans with PTSD (mean age = 30.09 years) were assigned to 15 treatment groups of 7-13 patients each. PGT was a 1-year therapy, 1.5 hour, once-a-week sessions administered in the following stages: group building activities, differentiation of group members, intimacy building, and termination...
January 24, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28068660/direct-to-consumer-genetic-testing-user-motivations-decision-making-and-perceived-utility-of-results
#3
J Scott Roberts, Michele C Gornick, Deanna Alexis Carere, Wendy R Uhlmann, Mack T Ruffin, Robert C Green
BACKGROUND/AIMS: To describe the interests, decision making, and responses of consumers of direct-to-consumer personal genomic testing (DTC-PGT) services. METHODS: Prior to 2013 regulatory restrictions on DTC-PGT services, 1,648 consumers from 2 leading companies completed Web surveys before and after receiving test results. RESULTS: Prior to testing, DTC-PGT consumers were as interested in ancestry (74% very interested) and trait information (72%) as they were in disease risks (72%)...
January 10, 2017: Public Health Genomics
https://www.readbyqxmd.com/read/28047535/su-f-i-38-patient-organ-specific-dose-assessment-in-coronary-ct-angiograph-using-voxellaized-volume-dose-index-in-monte-carlo-simulation
#4
Mohammadi Gh Fallal, Alam N Riyahi, Gh Graily, R Paydar
PURPOSE: Clinical use of multi detector computed tomography(MDCT) in diagnosis of diseases due to high speed in data acquisition and high spatial resolution is significantly increased. Regarding to the high radiation dose in CT and necessity of patient specific radiation risk assessment, the adoption of new method in the calculation of organ dose is completely required and necessary. In this study by introducing a conversion factor, patient organ dose in thorax region based on CT image data using MC system was calculated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28029661/multiple-drug-resistance-associated-protein-mrp4-exports-prostaglandin-e2-pge2-and-contributes-to-metastasis-in-basal-triple-negative-breast-cancer
#5
Tyler J Kochel, Jocelyn C Reader, Xinrong Ma, Namita Kundu, Amy M Fulton
Cyclooxygenase-2 (COX-2) and its primary enzymatic product, prostaglandin E2 (PGE2), are associated with a poor prognosis in breast cancer. In order to elucidate the factors contributing to intratumoral PGE2 levels, we evaluated the expression of COX-2/PGE2 pathway members MRP4, the prostaglandin transporter PGT, 15-PGDH (PGE2 metabolism), the prostaglandin E receptor EP4, COX-1, and COX-2 in normal, luminal, and basal breast cancer cell lines. The pattern of protein expression varied by cell line reflecting breast cancer heterogeneity...
January 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28011884/pharmacogenetics-and-pathophysiology-of-cacna1s-mutations-in-malignant-hyperthermia
#6
Teresa Ann Beam, Emily F Loudermilk, David F Kisor
A review of the pharmacogenetics (PGt) and pathophysiology of calcium voltage-gated channel subunit alpha1 S (CACNA1S) mutations in malignant hyperthermia susceptibility type 5 (MHS5; MIM #60188) is presented. Malignant hyperthermia (MH) is a life-threatening hypermetabolic state of skeletal muscle usually induced by volatile, halogenated anesthetics and/or the depolarizing neuromuscular blocker succinylcholine. In addition to ryanodine receptor 1 (RYR1) mutations, several CACNA1S mutations are known to be risk factors for increased susceptibility to MH (MHS)...
December 23, 2016: Physiological Genomics
https://www.readbyqxmd.com/read/27937091/personal-genomic-testing-for-cancer-risk-results-from-the-impact-of-personal-genomics-study
#7
Stacy W Gray, Sarah E Gollust, Deanna Alexis Carere, Clara A Chen, Angel Cronin, Sarah S Kalia, Huma Q Rana, Mack T Ruffin, Catharine Wang, J Scott Roberts, Robert C Green
Purpose Significant concerns exist regarding the potential for unwarranted behavior changes and the overuse of health care resources in response to direct-to-consumer personal genomic testing (PGT). However, little is known about customers' behaviors after PGT. Methods Longitudinal surveys were given to new customers of 23andMe (Mountain View, CA) and Pathway Genomics (San Diego, CA). Survey data were linked to individual-level PGT results through a secure data transfer process. Results Of the 1,042 customers who completed baseline and 6-month surveys (response rate, 71...
February 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27913634/comparative-analysis-highlights-variable-genome-content-of-wheat-rusts-and-divergence-of-the-mating-loci
#8
Christina A Cuomo, Guus Bakkeren, Hala Badr Khalil, Vinay Panwar, David Joly, Rob Linning, Sharadha Sakthikumar, Xiao Song, Xian Adiconis, Lin Fan, Jonathan M Goldberg, Joshua Z Levin, Sarah Young, Qiandong Zeng, Yehoshua Anikster, Myron Bruce, Meinan Wang, Chuntao Yin, Brent McCallum, Les J Szabo, Scot Hulbert, Xianming Chen, John P Fellers
Three members of the Puccinia genus, Pucciniatriticina (Pt), Pstriiformis f.sp. tritici (Pst), and Pgraminis f.sp. tritici (Pgt), cause the most common and often most significant foliar diseases of wheat. While similar in biology and life cycle, each species is uniquely adapted and specialized. The genomes of Pt and Pst were sequenced and compared to that of Pgt to identify common and distinguishing gene content, to determine gene variation among wheat rust pathogens, other rust fungi, and basidiomycetes, and to identify genes of significance for infection...
February 9, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27890709/role-of-major-and-brain-specific-sgce-isoforms-in-the-pathogenesis-of-myoclonus-dystonia-syndrome
#9
Jianfeng Xiao, Satya R Vemula, Yi Xue, Mohammad M Khan, Francesca A Carlisle, Adrian J Waite, Derek J Blake, Ioannis Dragatsis, Yu Zhao, Mark S LeDoux
Loss-of-function mutations in SGCE, which encodes ε-sarcoglycan (ε-SG), cause myoclonus-dystonia syndrome (OMIM159900, DYT11). A "major" ε-SG protein derived from CCDS5637.1 (NM_003919.2) and a "brain-specific" protein, that includes sequence derived from alternative exon 11b (CCDS47642.1, NM_001099400.1), are reportedly localized in post- and pre-synaptic membrane fractions, respectively. Moreover, deficiency of the "brain-specific" isoform and other isoforms derived from exon 11b may be central to the pathogenesis of DYT11...
February 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/27855520/novel-technologies-emerging-for-preimplantation-genetic-diagnosis-and-preimplantation-genetic-testing-for-aneuploidy
#10
Karen Sermon
Preimplantation genetic diagnosis (PGD) was introduced as an alternative to prenatal diagnosis: embryos cultured in vitro were analysed for a monogenic disease and only disease-free embryos were transferred to the mother, to avoid the termination of pregnancy with an affected foetus. It soon transpired that human embryos show a great deal of acquired chromosomal abnormalities, thought to explain the low success rate of IVF - hence preimplantation genetic testing for aneuploidy (PGT-A) was developed to select euploid embryos for transfer...
January 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27751827/response-of-gut-microbiota-and-inflammatory-status-to-bitter-melon-momordica-charantia-l-in-high-fat-diet-induced-obese-rats
#11
Juan Bai, Ying Zhu, Ying Dong
ETHNOPHARMACOLOGICAL RELEVANCE: Bitter melon (Momordica charantia L.) is rich in a variety of biologically active ingredients, and has been widely used in traditional Chinese medicine (TCM) to treat various diseases, including type 2 diabetes and obesity. AIM OF THE STUDY: We aimed to investigate how bitter melon powder (BMP) could affect obesity-associated inflammatory responses to ameliorate high-fat diet (HFD)-induced insulin resistance, and investigated whether its anti-inflammatory properties were effected by modulating the gut microbiota...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27705664/genetic-mapping-of-stem-rust-resistance-to-puccinia-graminis-f-sp-tritici-race-trttf-in-the-canadian-wheat-cultivar-harvest
#12
Colin W Hiebert, Matthew N Rouse, Jayaveeramuthu Nirmala, Tom Fetch
Stem rust, caused by Puccinia graminis f. sp. tritici, is a destructive disease of wheat that can be controlled by deploying effective stem rust resistance (Sr) genes. Highly virulent races of P. graminis f. sp. tritici in Africa have been detected and characterized. These include race TRTTF and the Ug99 group of races such as TTKSK. Several Canadian and U.S. spring wheat cultivars, including the widely grown Canadian cultivar 'Harvest', are resistant to TRTTF. However, the genetic basis of resistance to TRTTF in Canadian and U...
February 2017: Phytopathology
https://www.readbyqxmd.com/read/27637489/new-families-of-single-integration-vectors-and-gene-tagging-plasmids-for-genetic-manipulations-in-budding-yeast
#13
Victoria Wosika, Eric Durandau, Clémence Varidel, Delphine Aymoz, Marta Schmitt, Serge Pelet
The tractability of the budding yeast genome has provided many insights into the fundamental mechanisms regulating cellular life. With the advent of synthetic biology and single-cell measurements, novel tools are required to manipulate the yeast genome in a more controlled manner. We present, here, a new family of yeast shuttle vectors called single integration vectors (pSIV). Upon transformation in yeast, these plasmids replace the entire deficient auxotrophy marker locus by a cassette containing an exogenous marker...
December 2016: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/27624811/a-rapid-and-efficient-luminescence-based-method-for-assaying-phosphoglycosyltransferase-enzymes
#14
Debasis Das, Marthe T C Walvoort, Vinita Lukose, Barbara Imperiali
Phosphoglycosyltransferases (PGTs) are families of integral membrane proteins with intriguingly diverse architectures. These enzymes function to initiate many important biosynthetic pathways including those leading to peptidoglycan, N-linked glycoproteins and lipopolysaccharide O-antigen. In spite of tremendous efforts, characterization of these enzymes remains a challenge not only due to the inherent difficulties associated with the purification of integral membrane proteins but also due to the limited availability of convenient assays...
September 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27581540/fine-mapping-of-the-stem-rust-resistance-gene-srta10187
#15
Andrew T Wiersma, Linda K Brown, Elizabeth I Brisco, Tiffany L Liu, Kevin L Childs, Jesse A Poland, Sunish K Sehgal, Eric L Olson
SrTA10187 was fine-mapped to a 1.1 cM interval, candidate genes were identified in the region of interest, and molecular markers were developed for marker-assisted selection and Sr gene pyramiding. Stem rust (Puccinia graminis f. sp. tritici, Pgt) races belonging to the Ug99 (TTKSK) race group pose a serious threat to global wheat (Triticum aestivum L.) production. To improve Pgt host resistance, the Ug99-effective resistance gene SrTA10187 previously identified in Aegilops tauschii Coss. was introgressed into wheat, and mapped to the short arm of wheat chromosome 6D...
December 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27506534/genetics-and-mapping-of-seedling-resistance-to-ug99-stem-rust-in-winter-wheat-cultivar-triumph-64-and-differentiation-of-srtmp-srcad-and-sr42
#16
Colin W Hiebert, Mulualem T Kassa, Curt A McCartney, Frank M You, Matthew N Rouse, Pierre Fobert, Tom G Fetch
Resistance to Ug99 stem rust in Triumph 64 was conferred by SrTmp on chromosome arm 6DS and was mapped to the same position as SrCad and Sr42 , however, the three genes show functional differences. Stem rust, caused by Puccinia graminis f. sp. tritici (Pgt), is an important disease of wheat that can be controlled by effective stem rust resistance (Sr) genes. The emergence of virulent Pgt races in Africa, namely Ug99 and its variants, has stimulated the search for new Sr genes and genetic characterization of known sources of resistance...
November 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27462322/stem-rust-resistance-in-a-geographically-diverse-collection-of-spring-wheat-lines-collected-from-across-africa
#17
Renée Prins, Susanne Dreisigacker, Zakkie Pretorius, Hester van Schalkwyk, Elsabet Wessels, Corneli Smit, Cornel Bender, Davinder Singh, Lesley A Boyd
Following the emergence of the Ug99 lineage of Puccinia graminis f. sp. tritici (Pgt) a collective international effort has been undertaken to identify new sources of wheat stem rust resistance effective against these races. Analyses were undertaken in a collection of wheat genotypes gathered from across Africa to identify stem rust resistance effective against the Pgt races found in Eastern and Southern Africa. The African wheat collection consisted of historic genotypes collected in Kenya, South Africa, Ethiopia, Sudan, Zambia, Morocco, and Tunisia, and current South African breeding lines...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27373998/human-antibody-reactivity-against-xenogeneic-n-glycolylneuraminic-acid-and-galactose-%C3%AE-1-3-galactose-antigen
#18
Sunghoon Hurh, Bohae Kang, Inho Choi, Bumrae Cho, Eun Mi Lee, Hwajung Kim, Young June Kim, Yun Shin Chung, Jong Cheol Jeong, Jong-Ik Hwang, Jae Young Kim, Byeong Chun Lee, Charles D Surh, Jaeseok Yang, Curie Ahn
BACKGROUND: Despite the development of α1,3-galactosyl transferase-knockout (GTKO) pigs, acute humoral xenograft rejection caused by antibodies against non-Gal antigens, along with complement activation, are hurdles that need to be overcome. Among non-Gal antigens, N-glycolylneuraminic acid (Neu5Gc) is considered to play an important role in xenograft rejection in human. METHODS: We generated human embryonic kidney 293 (HEK293) cells that expressed xenogeneic Neu5Gc (HEK293-pCMAH) or α1,3Gal (HEK293-pGT) antigen and investigated the degree of human antibody binding and complement-dependent cytotoxicity (CDC) against these antigens using 100 individual human sera...
July 2016: Xenotransplantation
https://www.readbyqxmd.com/read/27309724/major-gene-for-field-stem-rust-resistance-co-locates-with-resistance-gene-sr12-in-thatcher-wheat
#19
Colin W Hiebert, James A Kolmer, Curt A McCartney, Jordan Briggs, Tom Fetch, Harbans Bariana, Frederic Choulet, Matthew N Rouse, Wolfgang Spielmeyer
Stem rust, caused by Puccinia graminis (Pgt), is a damaging disease of wheat that can be controlled by utilizing effective stem rust resistance genes. 'Thatcher' wheat carries complex resistance to stem rust that is enhanced in the presence of the resistance gene Lr34. The purpose of this study was to examine APR in 'Thatcher' and look for genetic interactions with Lr34. A RIL population was tested for stem rust resistance in field nurseries in Canada, USA, and Kenya. BSA was used to find SNP markers associated with reduced stem rust severity...
2016: PloS One
https://www.readbyqxmd.com/read/27292607/serum-platelet-derived-growth-factor-bb-levels-a-potential-biomarker-for-the-assessment-of-liver-fibrosis-in-patients-with-chronic-hepatitis-b
#20
Jiyuan Zhou, Yongqiong Deng, Linlin Yan, Hong Zhao, Guiqiang Wang
OBJECTIVES: Few studies have investigated serum levels of platelet-derived growth factor (PDGF) in patients with chronic hepatitis B (CHB). The present study aimed to determine whether PDGF-BB could serve as a potential biomarker for the detection of liver fibrosis. METHODS: From October 2013 to August 2015, 465 patients with CHB were enrolled prospectively in this study. All patients underwent liver biopsy and staging based on the Ishak system. The serum PDGF-BB level was measured quantitatively by ELISA...
August 2016: International Journal of Infectious Diseases: IJID
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