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https://www.readbyqxmd.com/read/27914146/pregnancy-and-delivery-in-a-generalized-dystonia-patient-treated-with-internal-globus-pallidal-deep-brain-stimulation-a-case-report
#1
Hye Ran Park, Jae Meen Lee, Hyeyoung Park, Chae Won Shin, Han Joon Kim, Hee Pyoung Park, Dong Gyu Kim, Beom Seok Jeon, Sun Ha Paek
Internal globus pallidus (GPi) deep brain stimulation (DBS) has been widely accepted as an effective treatment modality of medically refractory dystonia. However, there have been few studies regarding the safety issue of pregnancy and childbirth related with DBS. This report describes a female patient who was pregnant and delivered a baby after GPi DBS surgery. A 33-year-old female patient with acquired generalized dystonia underwent bilateral GPi DBS implantation. She obtained considerable improvement in both movement and disability after DBS implantation...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27903810/subthalamic-nucleus-deep-brain-stimulation-in-isolated-dystonia-a-3-year-follow-up-study
#2
Jill L Ostrem, Marta San Luciano, Kristen A Dodenhoff, Nathan Ziman, Leslie C Markun, Caroline A Racine, Coralie de Hemptinne, Monica M Volz, Susan L Heath, Philip A Starr
OBJECTIVE: To report long-term safety and efficacy outcomes of a large cohort of patients with medically refractory isolated dystonia treated with subthalamic nucleus (STN) deep brain stimulation (DBS). METHODS: Twenty patients (12 male, 8 female; mean age 49 ± 16.3 years) with medically refractory isolated dystonia were studied (14 were followed for 36 months). The primary endpoints were change in Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) motor score and Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) total score at 36 months compared to preoperative baseline...
November 30, 2016: Neurology
https://www.readbyqxmd.com/read/27873569/establishing-a-standard-of-care-for-deep-brain-stimulation-centers-in-canada
#3
Michel Panisset, Marina Picillo, Nicolas Jodoin, Yu-Yan Poon, Alejandro Valencia-Mizrachi, Alfonso Fasano, Renato Munhoz, Christopher R Honey
During the "DBS Canada Day" symposium held in Toronto July 4-5, 2014, the scientific committee invited experts to share their knowledge regarding deep brain stimulation (DBS) management of movement disorders in three domains: (1) the programming algorithms, (2) the necessary team to run a neurosurgery program, and (3) the appropriate scales to better define in a more comprehensive fashion the effect of the brain surgery. Each presentation was followed by an open discussion, and this article reports on the conclusions of this meeting on these three questions...
November 22, 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27862612/the-role-of-the-pallidothalamic-fibre-tracts-in-deep-brain-stimulation-for-dystonia-a-diffusion-mri-tractography-study
#4
Verena Eveline Rozanski, Nadia Moreira da Silva, Seyed-Ahmad Ahmadi, Jan Mehrkens, Joao da Silva Cunha, Jean-Christophe Houde, Christian Vollmar, Kai Bötzel, Maxime Descoteaux
BACKGROUND: Deep Brain Stimulation (DBS) of the Globus pallidus internus (GPi) is gold standard treatment in medically refractory dystonia. Recent evidence indicates that stimulation effects are also due to axonal modulation and affection of a fibre network. For the GPi, the pallidothalamic tracts are known to be the major motor efferent pathways. The aim of this study is to explore the anatomic vicinity of these tracts and DBS electrodes in dystonia applying diffusion tractography. METHODS: Diffusion MRI was acquired in ten patients presenting for DBS for dystonia...
November 16, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27862284/dystonia-deafness-syndrome-caused-by-a-%C3%AE-actin-gene-mutation-and-response-to-deep-brain-stimulation
#5
Hendriekje Eggink, Martje E van Egmond, Corien C Verschuuren-Bemelmans, Marleen C Schönherr, Tom J de Koning, D L Marinus Oterdoom, J Marc C van Dijk, Marina A J Tijssen
INTRODUCTION: Dystonia-deafness syndrome is a distinct clinical presentation within the dystonia-spectrum. Although several genetic and acquired causes have been reported, etiology remains unknown in the majority of patients. OBJECTIVES: To describe two patients with dystonia-deafness syndrome due to a beta-actin gene mutation. METHODS: We report on disease course, genetic testing, and management of 2 patients, mother and daughter, presenting with dystonia-deafness syndrome...
November 8, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27836806/hypometric-anticipatory-postural-adjustments-in-dystonia-are-not-affected-by-deep-brain-stimulation-of-globus-pallidus-internus
#6
Gregor Brecl Jakob, Olena Pelykh, Annika Plate, Zuzana Košutzká, Zvezdan Pirtošek, Maja Trošt, Joseph Ilmberger, Peter Valkovic, Jan H Mehrkens, Kai Bötzel
BACKGROUND: Dystonia is a movement disorder with patterned, directional, and often sustained muscle contractions that produce abnormal postures or repetitive movements. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is an effective and safe treatment for medically refractory dystonia. However, recent studies reported gait problems, gait freezing and falls in patients treated with DBS. Because these symptoms may point to deficient gait initiation processes, we systematically assessed the anticipatory postural adjustments (APAs) prior to stepping in dystonia patients with GPi-DBS...
January 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/27836441/stable-cognitive-functioning-with-improved-perceptual-reasoning-in-children-with-dyskinetic-cerebral-palsy-and-other-secondary-dystonias-after-deep-brain-stimulation
#7
Tamsin Owen, Dolapo Adegboye, Hortensia Gimeno, Richard Selway, Jean-Pierre Lin
BACKGROUND: Dystonia is characterised by involuntary movements (twisting, writhing and jerking) and postures. Secondary dystonias are described as a heterogeneous group of disorders with both exogenous and endogenous causes. There is a growing body of literature on the effects of deep brain stimulation (DBS) surgery on the motor function in childhood secondary dystonias, however research on cognitive function after DBS is scarce. METHODS: Cognitive function was measured in a cohort of 40 children with secondary dystonia following DBS surgery using a retrospective repeated measures design...
October 21, 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27821134/asphyxia-due-to-laryngeal-spasm-as-a-severe-complication-of-awake-deep-brain-stimulation-for-parkinson-s-disease-a-case-report
#8
Kajetan L von Eckardstein, Friederike Sixel-Döring, Stephan Kazmaier, Claudia Trenkwalder, Jason M Hoover, Veit Rohde
BACKGROUND: In accordance with German neurosurgical and neurological consensus recommendations, lead placements for deep brain stimulation (DBS) in patients with Parkinson's disease (PD) are usually performed with the patient awake and in "medication off" state. This allows for optimal lead position adjustment according to the clinical response to intraoperative test stimulation. However, exacerbation of Parkinsonian symptoms after withdrawal of dopaminergic medication may endanger the patient by inducing severe "off" state motor phenomena...
November 8, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27743838/deep-brain-stimulation-in-rare-inherited-dystonias
#9
Isabelle Beaulieu-Boire, Camila C Aquino, Alfonso Fasano, Yu-Yan Poon, Melanie Fallis, Antony E Lang, Mojgan Hodaie, Suneil K Kalia, Andres Lozano, Elena Moro
BACKGROUND: Rare causes of inherited movement disorders often present with a debilitating phenotype of dystonia, sometimes combined with parkinsonism and other neurological signs. Since these disorders are often resistant to medications, DBS may be considered as a possible treatment. METHODS: Patients with identified genetic diseases (ataxia-telangiectasia, chorea-achantocytosis, dopa-responsive dystonia, congenital nemaline myopathy, methylmalonic aciduria, neuronal ceroid lipofuscinosis, spinocerebellar ataxia types 2 and 3, Wilson's disease, Woodhouse-Sakati syndrome, methylmalonic aciduria, and X trisomy) and disabling dystonia underwent bilateral GPi DBS (bilateral thalamic Vim nucleus in 1 case)...
November 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27740598/rescue-procedures-after-suboptimal-deep-brain-stimulation-outcomes-in-common-movement-disorders
#10
Adam M Nagy, Christopher M Tolleson
Deep brain stimulation (DBS) is a unique, functional neurosurgical therapy indicated for medication refractory movement disorders as well as some psychiatric diseases. Multicontact electrodes are placed in "deep" structures within the brain with targets varying depending on the surgical indication. An implanted programmable pulse generator supplies the electrodes with a chronic, high frequency electrical current that clinically mimics the effects of ablative lesioning techniques. DBS's efficacy has been well established for its movement disorder indications (Parkinson's disease, essential tremor, and dystonia)...
October 8, 2016: Brain Sciences
https://www.readbyqxmd.com/read/27725721/time-course-of-coherence-in-the-human-basal-ganglia-during-voluntary-movements
#11
Omid Talakoub, Bogdan Neagu, Kaviraja Udupa, Eric Tsang, Robert Chen, Milos R Popovic, Willy Wong
We are interested in characterizing how brain networks interact and communicate with each other during voluntary movements. We recorded electrical activities from the globus pallidus pars interna (GPi), subthalamic nucleus (STN) and the motor cortex during voluntary wrist movements. Seven patients with dystonia and six patients with Parkinson's disease underwent bilateral deep brain stimulation (DBS) electrode placement. Local field potentials from the DBS electrodes and scalp EEG from the electrodes placed over the motor cortices were recorded while the patients performed externally triggered and self-initiated movements...
October 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27711133/developing-a-deep-brain-stimulation-neuromodulation-network-for-parkinson-disease-essential-tremor-and-dystonia-report-of-a-quality-improvement-project
#12
Richard B Dewey, Padraig E O'Suilleabhain, Manjit Sanghera, Neepa Patel, Pravin Khemani, Laura H Lacritz, Shilpa Chitnis, Louis A Whitworth, Richard B Dewey
OBJECTIVE: To develop a process to improve patient outcomes from deep brain stimulation (DBS) surgery for Parkinson disease (PD), essential tremor (ET), and dystonia. METHODS: We employed standard quality improvement methodology using the Plan-Do-Study-Act process to improve patient selection, surgical DBS lead implantation, postoperative programming, and ongoing assessment of patient outcomes. RESULTS: The result of this quality improvement process was the development of a neuromodulation network...
2016: PloS One
https://www.readbyqxmd.com/read/27707656/the-international-classification-of-functioning-icf-to-evaluate-deep-brain-stimulation-neuromodulation-in-childhood-dystonia-hyperkinesia-informs-future-clinical-research-priorities-in-a-multidisciplinary-model-of-care
#13
Hortensia Gimeno, Jean-Pierre Lin
The multidisciplinary team (MDT) approach illustrates how motor classification systems, assessments and outcome measures currently available have been applied to a national cohort of children and young people with dystonia and other hyperkinetic movement disorders (HMD) particularly with a focus on dyskinetic cerebral palsy (CP). The paper is divided in 3 sections. Firstly, we describe the service model adopted by the Complex Motor Disorders Service (CMDS) at Evelina London Children's Hospital and King's College Hospital (ELCH-KCH) for deep brain stimulation...
September 8, 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27696368/subthalamic-oscillatory-activity-in-parkinsonian-patients-with-off-period-dystonia
#14
X Li, P Zhuang, M Hallett, Y Zhang, J Li, Y Li
OBJECTIVES: The study was aimed to explore oscillatory activity in the subthalamic nucleus (STN) in Parkinson's disease (PD) with off-period dystonia, a type of levodopa-induced dyskinesias (LID). METHODS: Eighteen patients with PD who underwent STN DBS were studied. Nine patients had dyskinesia defined as the LID group and nine patients who did not present any sign of dyskinesia were defined as the control group. Microelectrode recordings in the STN together with electromyogram (EMG) were recorded...
November 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27693334/historical-developments-in-children-s-deep-brain-stimulation
#15
Laura Cif, Philippe Coubes
BACKGROUND: Heterogeneous by the underlying pathobiology and clinical presentation, childhood onset dystonia is most frequently progressive, with related disability and limitations in functions of daily living. Consequently, there is an obvious need for efficient symptomatic therapies. METHODS AND RESULTS: Following lesional surgery to basal ganglia (BG) and thalamus, deep brain stimulation (DBS) is a more conservative and adjustable intervention to and validated for internal segment of the globus pallidus (GPi), highly efficient in treating isolated "primary" dystonia and associated symptoms such as subcortical myoclonus...
September 7, 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27685658/clinical-outcome-and-intraoperative-neurophysiology-for-focal-limb-dystonic-tremor-without-generalized-dystonia-treated-with-deep-brain-stimulation
#16
Adolfo Ramirez-Zamora, Brian Kaszuba, Lucy Gee, Julia Prusik, Eric Molho, Meghan Wilock, Damian Shin, Julie G Pilitsis
OBJECTIVES: Dystonic tremor (DT) is defined as a postural/kinetic tremor occurring in the body region affected by dystonia. DT is typically characterized by focal tremors with irregular amplitudes and variable frequencies typically below 7Hz. Pharmacological treatment is generally unsuccessful and guidelines for deep brain stimulation (DBS) targeting and indications are scarce. In this article, we present the outcome and neurophysiologic data of two patients with refractory, focal limb DT treated with Globus Pallidus interna (Gpi) DBS and critically review the current literature regarding surgical treatment of DT discussing stereotactic targets and treatment considerations...
November 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27658770/what-parents-think-and-feel-about-deep-brain-stimulation-in-paediatric-secondary-dystonia-including-cerebral-palsy-a-qualitative-study-of-parental-decision-making
#17
Allana Austin, Jean-Pierre Lin, Richard Selway, Keyoumars Ashkan, Tamsin Owen
BACKGROUND: Dystonia is characterised by involuntary movements and postures. Deep Brain Stimulation (DBS) is effective in reducing dystonic symptoms in primary dystonia in childhood and to lesser extent in secondary dystonia. How families and children decide to choose DBS surgery has never been explored. AIMS: To explore parental decision-making for DBS in paediatric secondary dystonia. METHODS: Data was gathered using semi-structured interviews with eight parents of children with secondary dystonia who had undergone DBS...
September 6, 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27646126/a-diffusion-based-connectivity-map-of-the-gpi-for-optimised-stereotactic-targeting-in-dbs
#18
Nadia Moreira da Silva, Seyed-Ahmad Ahmadi, Sergio Neves Tafula, Joao Paulo Silva Cunha, Kai Bötzel, Christian Vollmar, Verena Eveline Rozanski
BACKGROUND: The GPi (globus pallidus internus) is an important target nucleus for Deep Brain Stimulation (DBS) in medically refractory movement disorders, in particular dystonia and Parkinson's disease. Beneficial clinical outcome critically depends on precise electrode localization. Recent evidence indicates that not only neurons, but also axonal fibre tracts contribute to promoting the clinical effect. Thus, stereotactic planning should, in the future, also take the individual course of fibre tracts into account...
September 16, 2016: NeuroImage
https://www.readbyqxmd.com/read/27593719/case-study-of-image-guided-deep-brain-stimulation-magnetic-resonance-imaging-based-white-matter-tractography-shows-differences-in-responders-and-nonresponders
#19
Rafael L O'Halloran, Alexander G Chartrain, Jonathan J Rasouli, Ritesh A Ramdhani, Brian Harris Kopell
BACKGROUND: The caudal zona incerta (cZI) is an increasingly popular deep brain stimulation (DBS) target for the treatment of tremor-predominant disease. The dentatorubrothalamic tract (DRTT) is a white matter fiber bundle that traverses the cZI and can be identified using diffusion-weighted magnetic resonance imaging fiber tractography to ascertain its precise course. In this report, we compare 2 patient cases of cZI DBS, a responder and a nonresponder. CASE DESCRIPTION: Patient 1 (responder) is a 65-year-old man with medically refractory Parkinson disease who underwent bilateral DBS lead placement in the cZI...
September 1, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27583182/the-pros-and-cons-of-intraoperative-ct-scan-in-evaluation-of-deep-brain-stimulation-lead-implantation-a-retrospective-study
#20
Domenico Servello, Edvin Zekaj, Christian Saleh, Claudio Pacchetti, Mauro Porta
BACKGROUND: Deep brain stimulation (DBS) is an established therapy for movement disorders, such as Parkinson's disease (PD), dystonia, and tremor. The efficacy of DBS depends on the correct lead positioning. The commonly adopted postoperative radiological evaluation is performed with computed tomography (CT) scan and/or magnetic resonance imaging (MRI). METHODS: We conducted a retrospective study on 202 patients who underwent DBS from January 2009 to October 2013...
2016: Surgical Neurology International
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