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https://www.readbyqxmd.com/read/29751598/informed-consent-decision-making-in-deep-brain-stimulation
#1
REVIEW
Gabriele Mandarelli, Germana Moretti, Massimo Pasquini, Giuseppe Nicolò, Stefano Ferracuti
Deep brain stimulation (DBS) has proved useful for several movement disorders (Parkinson’s disease, essential tremor, dystonia), in which first and/or second line pharmacological treatments were inefficacious. Initial evidence of DBS efficacy exists for refractory obsessive-compulsive disorder, treatment-resistant major depressive disorder, and impulse control disorders. Ethical concerns have been raised about the use of an invasive surgical approach involving the central nervous system in patients with possible impairment in cognitive functioning and decision-making capacity...
May 11, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29712499/lightning-may-pose-a-danger-to-patients-receiving-deep-brain-stimulation-case-report
#2
Neža Prezelj, Maja Trošt, Dejan Georgiev, Dušan Flisar
Deep brain stimulation (DBS) is an established treatment option for advanced stages of Parkinson's disease and other movement disorders. It is known that DBS is susceptible to strong electromagnetic fields (EMFs) that can be generated by various electrical devices at work, home, and in medical environments. EMFs can interfere with the proper functioning of implantable pulse generators (IPGs). Very strong EMFs can generate induction currents in implanted electrodes and even damage the brain. Manufacturers of DBS devices have issued a list of warnings on how to avoid this danger...
May 1, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29705556/deep-brain-stimulation-parameters-for-dystonia-a-systematic-review
#3
REVIEW
Philippe Magown, Rafael A Andrade, Alexandra Soroceanu, Zelma H T Kiss
INTRODUCTION: Programming of globus pallidus pars interna (GPi) deep brain stimulation (DBS) systems for dystonia is complex because clinical benefits are often gradual. Some groups have advocated starting DBS with higher electrical parameters, whereas others have suggested the opposite. This variability in programming, even within each dystonia subtype, makes it challenging to compare outcomes and program the generators. To determine how variable DBS for dystonia stimulation parameters are, we performed a systematic literature review...
April 17, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29679783/radiofrequency-lesioning-through-deep-brain-stimulation-electrodes-in-patients-with-generalized-dystonia
#4
Nobuhiko Takeda, Shiro Hoeisawa, Takaomi Taira, Takakazu Kawamata
BACKGROUND: Deep brain stimulation (DBS) is an established treatment for generalized dystonia. However, the DBS device is sometimes removed owing to hardware complications. Here, we present four cases of generalized dystonia treated with radiofrequency lesioning through the DBS electrodes. CASE DESCRIPTION: The patients were three men and one woman (34 to 44 years old). They had undergone DBS for generalized dystonia. However, they subsequently developed complications, such as infection, and removal of the devices became necessary...
April 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29661966/pallidal-deep-brain-stimulation-disrupts-pallidal-beta-oscillations-and-coherence-with-primary-motor-cortex-in-parkinson-s-disease
#5
Doris D Wang, Coralie de Hemptinne, Svjetlana Miocinovic, Jill L Ostrem, Nicholas B Galifianakis, Marta San Luciano, Philip A Starr
In Parkinson's disease (PD), subthalamic nucleus beta band oscillations are decreased by therapeutic deep brain stimulation (DBS) and this has been proposed as important to the mechanism of therapy. The globus pallidus is a common alternative target for PD with similar motor benefits as subthalamic DBS, but effects of pallidal stimulation in PD are not well studied, and effects of pallidal DBS on cortical function in PD are unknown. Here, in 20 PD and 14 isolated dystonia human patients of both genders undergoing pallidal DBS lead implantation, we recorded local field potentials (LFPs) from the globus pallidus and in a subset of these, recorded simultaneous sensorimotor cortex electrocorticography (ECoG) potentials...
April 16, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29576500/dualistic-effect-of-pallidal-deep-brain-stimulation-on-motor-speech-disorders-in-dystonia
#6
Jan Rusz, Tereza Tykalová, Anna Fečíková, Daniela Šťastná, Dušan Urgošík, Robert Jech
BACKGROUND: Although pallidal deep brain stimulation (GPi-DBS) is an effective treatment for dystonia, it may cause important stimulation-induced side-effects such as hypokinetic dysarthria or stuttering. However, the reasons behind the occurrence of these side-effects remain unknown. OBJECTIVE: To objectively investigate the impact of GPi-DBS on patients with dystonia on speech fluency, intelligibility, and key aspects of hyperkinetic and hypokinetic dysarthria...
March 15, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29558564/systems-approaches-to-optimizing-deep-brain-stimulation-therapies-in-parkinson-s-disease
#7
REVIEW
Sabato Santaniello, John T Gale, Sridevi V Sarma
Over the last 30 years, deep brain stimulation (DBS) has been used to treat chronic neurological diseases like dystonia, obsessive-compulsive disorders, essential tremor, Parkinson's disease, and more recently, dementias, depression, cognitive disorders, and epilepsy. Despite its wide use, DBS presents numerous challenges for both clinicians and engineers. One challenge is the design of novel, more efficient DBS therapies, which are hampered by the lack of complete understanding about the cellular mechanisms of therapeutic DBS...
March 20, 2018: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/29520331/reversal-of-status-dystonicus-after-relocation-of-pallidal-electrodes-in-dyt6-generalized-dystonia
#8
D L Marinus Oterdoom, Martje E van Egmond, Luisa Cassini Ascencao, J Marc C van Dijk, Assel Saryyeva, Martijn Beudel, Joachim Runge, Tom J de Koning, Mahmoud Abdallat, Hendriekje Eggink, Marina A J Tijssen, Joachim K Krauss
Background: DYT6 dystonia can have an unpredictable clinical course and the result of deep brain stimulation (DBS) of the internal part of the globus pallidus (GPi) is known to be less robust than in other forms of autosomal dominant dystonia. Patients who had previous stereotactic surgery with insufficient clinical benefit form a particular challenge with very limited other treatment options available. Case Report: A pediatric DYT6 patient unexpectedly deteriorated to status dystonicus 1 year after GPi DBS implantation with good initial clinical response...
2018: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/29503334/deep-brain-stimulation-for-movement-disorders-surgical-nuances
#9
Manmohan Singh, K V Shabari Girishan, Jitin Bajaj, Kanwaljeet Garg
Parkinson's disease (PD) and dystonia are common indications for the deep brain stimulation (DBS) procedure. It is very important to be diligent about target localization and execution of the procedure. The single most important predictor of a good postoperative outcome is proper patient selection. The various steps of performing DBS include taking a preoperative non - stereotactic MRI, stereotactic frame fixation, fusion of MRI with stereotactic CT scan images, planning of the target and trajectory, lead placement at target through the planned trajectory, implantation of pulse generator/ battery and programming of the implanted device...
March 2018: Neurology India
https://www.readbyqxmd.com/read/29503332/expanding-indications-for-deep-brain-stimulation
#10
Paresh K Doshi
It has been three decades since the first application of deep brain stimulation (DBS) for tremors was described by Benabid. Over the years, the indications for the performance of DBS have been expanding. There are now more than 1,50,000 patients around the world who have undergone DBS for various disorders. The main appeal of DBS is in its reversibility and titratability. Though the initial interest in DBS was for pain, the main indications for DBS have been movement disorders. Despite its wide appeal and "perceived" advantage, United States Food and Drug Administration, the nodal agency for approving therapies, has been cautious and guarded in providing approvals...
March 2018: Neurology India
https://www.readbyqxmd.com/read/29486999/prospective-evaluation-of-globus-pallidus-internus-deep-brain-stimulation-in-huntington-s-disease
#11
S Zittel, V Tadic, C K E Moll, T Bäumer, A Fellbrich, A Gulberti, D Rasche, N Brüggemann, V Tronnier, A Münchau
INTRODUCTION: Pharmacological treatment of chorea in Huntington's disease (HD) is often limited by poor efficacy or side effects. Pallidal deep brain stimulation (DBS) has been considered in these patients but experience is so far limited. METHODS: We prospectively evaluated the effects of bilateral DBS of the Globus pallidus internus (GPi) over one year in six severely affected HD patients with treatment refractory chorea in an advanced stage of the disease. Primary endpoint of the study was improvement in chorea...
February 20, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29433807/deep-brain-stimulation-for-tardive-syndromes-systematic-review-and-meta-analysis
#12
REVIEW
Antonella Macerollo, Günther Deuschl
Among the broad entity of tardive syndromes, tardive dystonia and classical tardive dyskinesia sometimes require advanced treatments like deep brain stimulation of the globus pallidus internum (Gpi-DBS) or the subthalamic nucleus (STN-DBS). This systematic review has analyzed the currently available literature reporting cases with either tardive dystonia or dyskinesia treated with DBS. The key words for the literature search included all tardive syndromes and "deep brain stimulation." Thirty-four level VI studies and one level II study with 117 patients were included...
June 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29431884/successes-and-optimism-in-deep-brain-stimulation-for-neurological-disorders-ripe-for-a-surgical-time-out
#13
EDITORIAL
A I Tröster
No abstract text is available yet for this article.
May 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29414403/postoperative-rehabilitation-after-deep-brain-stimulation-surgery-for-movement-disorders
#14
REVIEW
Niels Allert, Binith Cheeran, Günther Deuschl, Michael T Barbe, Ilona Csoti, Markus Ebke, Martin Glaser, Jun-Suk Kang, Stefan Kelm, Paul Krack, Julia Kroth, Ulrich Jobst, Markus Leisse, Antonio Oliviero, Peter Nikolaus Nolte, Johanna Quick-Weller, Martin Strothjohann, Gertrúd Tamás, Michael Werner, Muthuraman Muthuraman, Jens Volkmann, Alfonso Fasano, Sergiu Groppa
Deep brain stimulation (DBS) is a highly efficient, evidence-based therapy for a set of neurological and psychiatric conditions and especially movement disorders such as Parkinson's disease, essential tremor and dystonia. Recent developments have improved the DBS technology. However, no unequivocal algorithms for an optimized postoperative care exist so far. The aim of this review is to provide a synopsis of the current clinical practice and to propose guidelines for postoperative and rehabilitative care of patients who undergo DBS...
March 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29405267/pharmacological-and-neurosurgical-interventions-for-managing-dystonia-in-cerebral-palsy-a-systematic-review
#15
Darcy Fehlings, Leah Brown, Adrienne Harvey, Kate Himmelmann, Jean-Pierre Lin, Alexander Macintosh, Jonathan W Mink, Elegast Monbaliu, James Rice, Jessica Silver, Lauren Switzer, Ilana Walters
AIM: To systematically review evidence for pharmacological/neurosurgical interventions for managing dystonia in individuals with cerebral palsy (CP) to inform a care pathway. METHOD: Searches included studies with a minimum of five participants with dystonia in CP receiving oral baclofen, benzodiazepines (clonazepam, diazepam, lorazepam), clonidine, gabapentin, levodopa, trihexyphenidyl, botulinum toxin, intrathecal baclofen (ITB), or deep brain stimulation (DBS)...
April 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29396170/deep-brain-stimulation-for-dystonia-due-to-cerebral-palsy-a-review
#16
REVIEW
Antonio E Elia, Caterina F Bagella, Francesca Ferré, Giovanna Zorzi, Daniela Calandrella, Luigi M Romito
Cerebral palsy (CP) is a heterogeneous group of syndromes that cause a non-progressive disorder of early onset, with abnormal control of movement and posture. Various aetiologies can cause the CP clinical spectrum, but all have a disruption of motor control in common. CP can be divided into four major types based on the motor disability: predominant spastic, dyskinetic, ataxic and mixed form. Dyskinetic CP (DCP) is the most common cause of acquired dystonia in children. The treatment of DCP is challenging because most individuals have mixed degrees of chorea, athetosis and dystonia...
March 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29396066/successful-deep-brain-stimulation-for-central-post-stroke-pain-and-dystonia-in-a-single-operation
#17
Marshall T Holland, Mario Zanaty, Luyuan Li, Teri Thomsen, James H Beeghly, Jeremy D W Greenlee, Chandan G Reddy
BACKGROUND: Central post-stroke pain is known to be refractory to medications and difficult to manage. We present a case of central post-stroke pain associated with dystonia. Both conditions were successfully treated with a single deep brain stimulation (DBS) operation. CASE DESCRIPTION: A 60-year-old female suffered a right posterior cerebral artery stroke following emergent clipping of a ruptured posterior cerebral artery aneurysm resulting in central post-stroke pain...
April 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29396058/stuttering-in-parkinson-s-disease-after-deep-brain-stimulation-a-note-on-dystonia-and-low-frequency-stimulation
#18
Marcelo D Mendonça, Raquel Barbosa, Alexandra Seromenho-Santos, Carla Reizinho, Paulo Bugalho
Stuttering, a speech fluency disorder, is a rare complication of Deep Brain Stimulation (DBS) in Parkinson's Disease (PD). We report a 61 years-old patient with PD, afflicted by severe On and Off dystonia, treated with Subthalamic Nucleus DBS that developed post-DBS stuttering while on 130 Hz stimulation. Stuttering reduction was noted when frequency was changed to 80 Hz, but the previously observed dystonia improvement was lost. There are no reports in literature on patients developing stuttering with low-frequency stimulation...
April 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29369401/pallidal-deep-brain-stimulation-modulates-cortical-excitability-and-plasticity
#19
Zhen Ni, Sang Jin Kim, Nicolas Phielipp, Soumya Ghosh, Kaviraja Udupa, Carolyn A Gunraj, Utpal Saha, Mojgan Hodaie, Suneil K Kalia, Andres M Lozano, Darrin J Lee, Elena Moro, Alfonso Fasano, Mark Hallett, Anthony E Lang, Robert Chen
OBJECTIVE: Internal globus pallidus (GPi) deep brain stimulation (DBS) relieves symptoms in dystonia patients. However, the physiological effects produced by GPi DBS are not fully understood. In particular, how a single-pulse GPi DBS changes cortical circuits has never been investigated. We studied the modulation of motor cortical excitability and plasticity with single-pulse GPi DBS in dystonia patients with bilateral implantation of GPi DBS. METHODS: The cortical evoked potentials from DBS were recorded with electroencephalography...
February 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29350600/long-term-outcome-of-pallidal-stimulation-for-meige-syndrome
#20
Shiro Horisawa, Taku Ochiai, Shinichi Goto, Takeshi Nakajima, Nobuhiko Takeda, Takakazu Kawamata, Takaomi Taira
OBJECTIVE Meige syndrome is characterized by blepharospasm and varied subphenotypes of craniocervical dystonia. Current literature on pallidal surgery for Meige syndrome is limited to case reports and a few small-scale studies. The authors investigated the clinical outcomes of deep brain stimulation (DBS) of the globus pallidus internus (GPi) in patients with Meige syndrome. METHODS Sixteen patients who underwent GPi DBS at the Tokyo Women's Medical University Hospital between 2002 and 2015 were included in this study...
January 19, 2018: Journal of Neurosurgery
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