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Parkinson AND PDRP

Paul J Mattis, Martin Niethammer, Wataru Sako, Chris C Tang, Amir Nazem, Marc L Gordon, Vicky Brandt, Vijay Dhawan, David Eidelberg
OBJECTIVE: To determine whether cognitive impairment in Parkinson disease (PD) and Alzheimer disease (AD) derives from the same network pathology. METHODS: We analyzed (18)F-fluorodeoxyglucose PET scans from 40 patients with AD and 40 age-matched healthy controls from the Alzheimer's Disease Neuroimaging Initiative and scanned an additional 10 patients with AD and 10 healthy controls at The Feinstein Institute for Medical Research to derive an AD-related metabolic pattern (ADRP) analogous to our previously established PD cognition-related pattern (PDCP) and PD motor-related pattern (PDRP)...
October 5, 2016: Neurology
Wei-Xi Xiong, Yi-Min Sun, Rong-Yuan Guan, Su-Shan Luo, Chen Chen, Yu An, Jian Wang, Jian-Jun Wu
The missense mutation A53T of alpha-synuclein gene (SNCA) was reported to be a rare but definite cause of sporadic and familial Parkinson disease (PD). It seemed to be restricted geographically in Greece and Italy. We aimed to identify the SNCA mutations in a Chinese PD cohort. Ninety-one early onset PD patients or familial PD probands were collected consecutively for the screening of PD-related genes. The genetic analysis was carried out by target sequencing of the exons and the corresponding flanking regions of the PD-related genes using Illumina HiSeq 2000 sequencer and further confirmed by Sanger sequencing or restriction fragment length polymorphism...
October 2016: Journal of Neurology
Florian Holtbernd, Yilong Ma, Shichun Peng, Frank Schwartz, Lars Timmermann, Lutz Kracht, Gereon R Fink, Chris C Tang, David Eidelberg, Carsten Eggers
Parkinson's disease (PD) is associated with distinct metabolic covariance patterns that relate to the motor and cognitive manifestations of the disorder. It is not known, however, how the expression of these patterns relates to measurements of nigrostriatal dopaminergic activity from the same individuals. To explore these associations, we studied 106 PD subjects who underwent cerebral PET with both (18) F-fluorodeoxyglucose (FDG) and (18) F-fluoro-L-dopa (FDOPA). Expression values for the PD motor- and cognition-related metabolic patterns (PDRP and PDCP, respectively) were computed for each subject; these measures were correlated with FDOPA uptake on a voxel-by-voxel basis...
September 2015: Human Brain Mapping
Florian Holtbernd, Jean-François Gagnon, Ron B Postuma, Yilong Ma, Chris C Tang, Andrew Feigin, Vijay Dhawan, Mélanie Vendette, Jean-Paul Soucy, David Eidelberg, Jacques Montplaisir
OBJECTIVE: To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion. METHODS: For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8...
February 18, 2014: Neurology
Shichun Peng, Yilong Ma, Phoebe G Spetsieris, Paul Mattis, Andrew Feigin, Vijay Dhawan, David Eidelberg
To generate imaging biomarkers from disease-specific brain networks, we have implemented a general toolbox to rapidly perform scaled subprofile modeling (SSM) based on principal component analysis (PCA) on brain images of patients and normals. This SSMPCA toolbox can define spatial covariance patterns whose expression in individual subjects can discriminate patients from controls or predict behavioral measures. The technique may depend on differences in spatial normalization algorithms and brain imaging systems...
May 2014: Human Brain Mapping
Ping Wu, Jian Wang, Shichun Peng, Yilong Ma, Huiwei Zhang, Yihui Guan, Chuantao Zuo
The objective of this study was to validate Parkinson's disease-related pattern (PDRP) as a measure of network biomarker of Parkinson's disease (PD) in Chinese population by using 18F-fluorodeoxyglucose (FDG) and Positron Emission Tomography (PET). Resting-state brain FDG PET imaging was performed in a cohort of 33 PD patients and 33 age/gender-matched healthy controls to identify a PDRP. PDRP expression was then computed in a new cohort of 30 PD patients and 30 healthy controls using a voxel-based network quantification algorithm...
June 2013: Parkinsonism & related Disorders
Vijay Dhawan, Chris C Tang, Yilong Ma, Phoebe Spetsieris, David Eidelberg
Changes in regional brain activity can be observed following global normalization procedures to reduce variability in the data. In particular, spurious regional differences may appear when scans from patients with low global activity are compared to those from healthy subjects. It has thus been suggested that the consistent increases in subcortical activity that characterize the abnormal Parkinson's disease-related metabolic covariance pattern (PDRP) are artifacts of global normalization, and that similar topographies can be identified in scans from healthy subjects with varying global activity...
December 2012: NeuroImage
K L Poston, C C Tang, T Eckert, V Dhawan, S Frucht, J-P Vonsattel, S Fahn, D Eidelberg
OBJECTIVE: Multiple system atrophy (MSA), the most common of the atypical parkinsonian disorders, is characterized by the presence of an abnormal spatial covariance pattern in resting state metabolic brain images from patients with this disease. Nonetheless, the potential utility of this pattern as a MSA biomarker is contingent upon its specificity for this disorder and its relationship to clinical disability in individual patients. METHODS: We used [(18)F]fluorodeoxyglucose PET to study 33 patients with MSA, 20 age- and severity-matched patients with idiopathic Parkinson disease (PD), and 15 healthy volunteers...
April 17, 2012: Neurology
Hideo Mure, Shigeki Hirano, Chris C Tang, Ioannis U Isaias, Angelo Antonini, Yilong Ma, Vijay Dhawan, David Eidelberg
The circuit changes that mediate parkinsonian tremor, while likely differing from those underlying akinesia and rigidity, are not precisely known. In this study, to identify a specific metabolic brain network associated with this disease manifestation, we used FDG PET to scan nine tremor dominant Parkinson's disease (PD) patients at baseline and during ventral intermediate (Vim) thalamic nucleus deep brain stimulation (DBS). Ordinal trends canonical variates analysis (OrT/CVA) was performed on the within-subject scan data to detect a significant spatial covariance pattern with consistent changes in subject expression during stimulation-mediated tremor suppression...
January 15, 2011: NeuroImage
Chris C Tang, Kathleen L Poston, Vijay Dhawan, David Eidelberg
Imaging studies show that Parkinson's disease (PD) alters the activity of motor- and cognition-related metabolic brain networks. However, it is not known whether the network changes appear at or before symptom onset. In this study, we examined 15 hemiparkinsonian patients who underwent serial metabolic imaging with [(18)F]-fluorodeoxyglucose (FDG) PET at baseline and again 2.1 +/- 0.6 (mean +/- SD) and 3.9 +/- 0.7 years later. We assessed longitudinal changes in network activity in each cerebral hemisphere, focusing specifically on the "presymptomatic" hemisphere--ipsilateral to the initially involved body side...
January 20, 2010: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Yilong Ma, Chaorui Huang, Jonathan P Dyke, Hong Pan, David Alsop, Andrew Feigin, David Eidelberg
Parkinson's disease (PD) is associated with elevated expression of a specific disease-related spatial covariance pattern (PDRP) in radiotracer scans of cerebral blood flow and metabolism. In this study, we scanned nine early-stage patients with PD and nine healthy controls using continuous arterial spin labeling (CASL) perfusion magnetic resonance imaging (pMRI). Parkinson's disease-related metabolic pattern expression in CASL pMRI scans was compared with the corresponding (18)F-fluorodeoxyglucose positron emission tomography values...
March 2010: Journal of Cerebral Blood Flow and Metabolism
Jian Wang, YiLong Ma, ZheMin Huang, BoMin Sun, YiHui Guan, ChuanTao Zuo
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) was proposed as an effective way to improve the symptoms of Parkinson's disease (PD). We studied metabolic modulation in the brain by bilateral STN stimulation using FDG PET. Five PD patients (age 61.6 +/- 3.9 years) at advanced stage were scanned under OFF and ON conditions of stimulation. Network analysis was used to evaluate the effect of stimulation on the expression of an abnormal Parkinson's disease-related spatial covariance pattern (PDRP)...
January 2010: Journal of Neurology
Per Borghammer, Paul Cumming, Joel Aanerud, Stefan Förster, Albert Gjedde
In a recent issue of NeuroImage, we presented evidence that biased global mean (GM) normalization of brain PET data can generate the appearance of subcortical foci with relative hypermetabolism in patients with Parkinson's disease (PD), and other degenerative disorders. In a commentary to our article, Ma and colleagues presented a study seeking to establish that a pattern of widespread hypermetabolism, known as the Parkinson's disease related pattern (PDRP) is a genuine metabolic feature of PD. In the present paper, we respond to the arguments presented by Ma et al...
October 1, 2009: NeuroImage
Chaorui Huang, Chengke Tang, Andrew Feigin, Martin Lesser, Yilong Ma, Michael Pourfar, Vijay Dhawan, David Eidelberg
Parkinson's disease (PD) is associated with abnormal activity in spatially distributed neural systems mediating the motor and cognitive manifestations of this disorder. Metabolic PET studies have demonstrated that this illness is characterized by a set of reproducible functional brain networks that correlate with these clinical features. The time at which these abnormalities appear is unknown, as is their relationship to concurrent clinical and dopaminergic indices of disease progression. In this longitudinal study, 15 early stage PD patients (age 58...
July 2007: Brain: a Journal of Neurology
Thomas Eckert, Koen Van Laere, Chengke Tang, Daniel E Lewis, Christine Edwards, Patrick Santens, David Eidelberg
PURPOSE: Spatial covariance analysis has been used with FDG PET to identify a specific metabolic network associated with Parkinson's disease (PD). In the current study, we utilized a new, fully automated voxel-based method to quantify network expression in ECD SPECT images from patients with classical PD, patients with multiple system atrophy (MSA), and healthy control subjects. METHODS: We applied a previously validated voxel-based PD-related covariance pattern (PDRP) to quantify network expression in the ECD SPECT scans of 35 PD patients, 15 age- and disease severity-matched MSA patients, and 35 age-matched healthy control subjects...
April 2007: European Journal of Nuclear Medicine and Molecular Imaging
Kotaro Asanuma, Chengke Tang, Yilong Ma, Vijay Dhawan, Paul Mattis, Christine Edwards, Michael G Kaplitt, Andrew Feigin, David Eidelberg
It has been proposed that deep brain stimulation (DBS) of the subthalamic nucleus (STN DBS) and dopaminergic therapy ameliorate the symptoms of Parkinson's disease through similar functional mechanisms. We examined this notion using PET to compare the metabolic effects of these treatment approaches. Nine Parkinson's disease patients (age 61.7 +/- 11.1 years) were scanned ON and OFF STN stimulation and nine others (age 60.0 +/- 9.3 years) were scanned ON and OFF an individual titrated intravenous levodopa infusion...
October 2006: Brain: a Journal of Neurology
Yilong Ma, Chengke Tang, Phoebe G Spetsieris, Vijay Dhawan, David Eidelberg
Parkinson's disease (PD) is associated with an abnormal pattern of regional brain function. The expression of this PD-related covariance pattern (PDRP) has been used to assess disease progression and the response to treatment. In this study, we validated the PDRP network as a measure of parkinsonism by prospectively computing its expression (PDRP scores) in (15)O-water (H(2)(15)O) and (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) scans from PD patients and healthy volunteers. The reliability of this measure was also assessed within subjects using a test-retest design in mildly affected and advanced PD patients scanned at baseline and during treatment with levodopa or deep brain stimulation (DBS)...
March 2007: Journal of Cerebral Blood Flow and Metabolism
Maja Trost, Sherwin Su, Philip Su, Ruoh-Fang Yen, Ham-Min Tseng, Anna Barnes, Yilong Ma, David Eidelberg
Deep brain stimulation of the subthalamic nucleus (STN DBS) has become an accepted tool for the treatment of Parkinson's disease (PD). Although the precise mechanism of action of this intervention is unknown, its effectiveness has been attributed to the modulation of pathological network activity. We examined this notion using positron emission tomography (PET) to quantify stimulation-induced changes in the expression of a PD-related covariance pattern (PDRP) of regional metabolism. These metabolic changes were also compared with those observed in a similar cohort of patients undergoing STN lesioning...
May 15, 2006: NeuroImage
A Feigin, M Fukuda, V Dhawan, S Przedborski, V Jackson-Lewis, M J Mentis, J R Moeller, D Eidelberg
OBJECTIVE: To assess the effects of levodopa on resting-state brain metabolism in PD. BACKGROUND: In previous studies the authors used [18F] fluorodeoxyglucose (FDG) and PET to quantify regional metabolic abnormalities in PD. They found that this disease is characterized reproducibly by a specific abnormal PD-related pattern (PDRP). In this study the authors used IV levodopa infusion to quantify the effects of dopamine replacement on regional metabolism and PDRP network activity...
December 11, 2001: Neurology
M Fukuda, M J Mentis, Y Ma, V Dhawan, A Antonini, A E Lang, A M Lozano, J Hammerstad, K Lyons, W C Koller, J R Moeller, D Eidelberg
Employing [(18)F]fluorodeoxyglucose (FDG) and PET, we have found previously that stereotaxic ablation of the internal globus pallidus (GPi) for Parkinson's disease causes resting metabolic changes in brain regions remote from the lesion site. In this study we determined whether similar metabolic changes occur in Parkinson's disease patients treated with deep brain stimulation (DBS) of the GPi. We studied seven Parkinson's disease patients with FDG-PET to measure resting regional cerebral glucose utilization on and off GPi stimulation...
August 2001: Brain: a Journal of Neurology
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