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Fetal doppel

Jamil Kanaani, Stanley B Prusiner, Julia Diacovo, Steinunn Baekkeskov, Giuseppe Legname
While a beta-sheet-rich form of the prion protein (PrPSc) causes neurodegeneration, the biological activity of its precursor, the cellular prion protein (PrPC), has been elusive. We have studied the effect of purified recombinant prion protein (recPrP) on rat fetal hippocampal neurons in culture. Overnight exposure to Syrian hamster or mouse recPrP, folded into an alpha-helical-rich conformation similar to that of PrPC, resulted in a 1.9-fold increase in neurons with a differentiated axon, a 13.5-fold increase in neurons with differentiated dendrites, a fivefold increase in axon length, and the formation of extensive neuronal circuitry...
December 2005: Journal of Neurochemistry
Eleni Makrinou, John Collinge, Michael Antoniou
Prion protein (PrP) is intimately linked with a class of neurodegenerative diseases known as transmissible spongiform encephalopathies (TSEs). Employing bioinformatics and direct molecular analysis, we demonstrated that the human PrP gene (PRNP) locus, which is situated at Chromosome (Chr) position 20p12-ter, contains three genes within a 55-kb interval: PRNP; DOPPEL or PRND, located 20 kb 3' of PRNP; and a novel gene, designated PRNT, that maps 3 kb 3' to PRND and is transcribed to generate at least three alternatively spliced mRNAs...
December 2002: Mammalian Genome: Official Journal of the International Mammalian Genome Society
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