Natalia Yudintceva, Danila Bobkov, Maksim Sulatsky, Natalia Mikhailova, Elena Oganesyan, Tatiana Vinogradova, Alexandr Muraviov, Anna Remezova, Evdokia Bogdanova, Irina Garapach, Olga Maslak, Dilyara Esmedlyaeva, Marina Dyakova, Petr Yablonskiy, Rustam Ziganshin, Sergey Kovalchuk, Natalya Blum, Shirish H Sonawane, Avinash Sonawane, Ankita Behl, Shailja Singh, Maxim Shevtsov
Extrapulmonary tuberculosis with a renal involvement can be a manifestation of a disseminated infection that requires therapeutic intervention, particularly with a decrease in efficacy of conventional regimens. In the present study, we investigated the therapeutic potency of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in the complex anti-tuberculosis treatment (ATT). A rabbit model of renal tuberculosis (rTB) was constructed by injecting of the standard strain Mycobacterium tuberculosis H37Rv into the cortical layer of the kidney parenchyma...
February 24, 2024: Scientific Reports