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https://www.readbyqxmd.com/read/29781535/mir-1178-regulates-mycobacterial-survival-and-inflammatory-responses-in-mycobacterium-tuberculosis-infected-macrophages-partly-via-tlr4
#1
Ge Shi, Guofeng Mao, Kejie Xie, Dongdong Wu, Wei Wang
Tuberculosis is chronic respiratory infectious disease and is caused by the infection of Mycobacterium tuberculosis (M.tb). Macrophages play an important role in host immune response against M.tb infection, which is regulated by various factors, including microRNAs (miRNAs). The present study aimed to examine the in vitro functional role of miR-1178 in mycobacterial survival and inflammatory responses induced by M.tb infection in human macrophages. Our results showed that M.tb infection increased the expression of miR-1178 in human macrophages (HTP-1 and U937 cells) in a concentration- and time-dependent manner...
May 21, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29779777/interleukin-23-interleukin-17-axis-activated-by-mycobacterium-avium-complex-mac-is-attenuated-in-patients-with-mac-lung-disease
#2
Chin-Chung Shu, Jann-Yuan Wang, Ming-Fang Wu, Hsin-Chih Lai, Bor-Luen Chiang, Chong-Jen Yu
BACKGROUND: Mycobacterium avium complex (MAC)-lung disease (LD) is increasing in patients without human immunodeficiency virus infection. However, data on host vulnerability to MAC-related immune responses, and in particular the interleukin (IL)-23/IL-17 axis, are lacking. METHODS: We enrolled 50 patients with MAC-LD, 25 age-matched patients with tuberculosis (TB) and 25 controls. We measured levels of plasma cytokines, and studied IL-12/IL-17 responses in macrophage and lymphocyte activation to MAC...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29779765/prolonged-intervals-during-mycobacterium-tuberculosis-subunit-vaccine-boosting-contributes-to-eliciting-immunity-mediated-by-central-memory-like-t-cells
#3
Chunxiang Bai, Juanjuan He, Hongxia Niu, Lina Hu, Yanping Luo, Xun Liu, Liang Peng, Bingdong Zhu
It is believed that central memory T cells (TCM ) provide long-term protection against tuberculosis (TB). However, the effects of TB subunit vaccine immunization schedule, especially the vaccination intervals, on T cell immune memory is still unclear. In this study, mice were immunized with fusion protein ESAT6-Ag85B-MPT64 (190-198)-Mtb8.4-Rv2626c (LT70) based subunit vaccine three times according to the following schedules: ① 0, 3rd and 6th week respectively (0-3-6w), ② 0, 4th and 12th week (0-4-12w), and ③ 0, 4th and 24th week (0-4-24w)...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29777718/malnutrition-is-associated-with-diminished-baseline-and-mycobacterial-antigen-stimulated-chemokine-responses-in-latent-tuberculosis-infection
#4
Rajamanickam Anuradha, Saravanan Munisankar, Yukthi Bhootra, Nathella Pavan Kumar, Chandrakumar Dolla, Subash Babu
OBJECTIVES: Previous studies have demonstrated a diminution in the baseline and mycobacterial antigen - specific cytokines in low body mass index (LBMI) individuals with latent tuberculosis infection (LTBI). We hypothesized that LBMI might be also associated with alteration in the baseline and antigen - stimulated levels of chemokines in LTBI. METHODS: To test this hypothesis, we examined baseline, TB- antigen and mitogen stimulated levels of chemokines in these individuals and compared them with those with LTBI and normal BMI (NBMI)...
May 16, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29765355/tuberculosis-the-disrupted-immune-endocrine-response-and-the-potential-thymic-repercussion-as-a-contributing-factor-to-disease-physiopathology
#5
REVIEW
Luciano D'Attilio, Natalia Santucci, Bettina Bongiovanni, María L Bay, Oscar Bottasso
Upon the pathogen encounter, the host seeks to ensure an adequate inflammatory reaction to combat infection but at the same time tries to prevent collateral damage, through several regulatory mechanisms, like an endocrine response involving the production of adrenal steroid hormones. Our studies show that active tuberculosis (TB) patients present an immune-endocrine imbalance characterized by an impaired cellular immunity together with increased plasma levels of cortisol, pro-inflammatory cytokines, and decreased amounts of dehydroepiandrosterone...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29764370/-tuberculosis-in-advanced-hiv-infection-is-associated-with-increased-expression-of-ifn%C3%AE-and-its-downstream-targets
#6
Sheetal Verma, Peicheng Du, Damalie Nakanjako, Sabine Hermans, Jessica Briggs, Lydia Nakiyingi, Jerrold J Ellner, Yukari C Manabe, Padmini Salgame
BACKGROUND: Tuberculosis (TB) is the major cause of death in Human Immunodeficiency Virus (HIV)-infected individuals. However, diagnosis of TB in HIV remains challenging particularly when HIV infection is advanced. Several gene signatures and serum protein biomarkers have been identified that distinguish active TB from latent infection. Our study was designed to assess if gene expression signatures and cytokine levels would distinguish active TB in advanced HIV. METHODS: We conducted a case-control study of whole blood RNA-Seq and plasma cytokine/chemokine analysis in HIV-infected with CD4+ T cell count of ≤ 100 cells/μl, with and without active TB...
May 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29760437/cd82-hypomethylation-is-essential-for-tuberculosis-pathogenesis-via-regulation-of-runx1-rab5-22
#7
Hyun-Jung Koh, Ye-Ram Kim, Jae-Sung Kim, Jin-Seung Yun, Sojin Kim, Sun Young Kim, Kiseok Jang, Chul-Su Yang
The tumor suppressor gene CD82/KAI1 is a member of the tetraspanin superfamily and organizes various membrane-based processes. Mycobacterium tuberculosis (MTB) persists in host macrophages by interfering with phagolysosome biogenesis and inflammatory responses, but the role of CD82 in controlling the intracellular survival of pathogenic mycobacteria within macrophages remains poorly understood. In this study, we demonstrated that the virulent MTB strain H37Rv (MTB Rv) induced CD82 promoter hypomethylation, resulting in CD82 expression...
May 14, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29756540/immunological-recovery-in-patients-with-pulmonary-tuberculosis-after-intensive-phase-treatment
#8
Xuejiao Luo, Furong Wu, Jun Ma, Heping Xiao, Haiyan Cui
Objectives This study aimed to examine the change and significance of immune parameters in patients with sputum smear-positive pulmonary tuberculosis (TB) after 2 months of intensive phase anti-TB treatment. Methods The immune parameters of 232 cases of sputum smear-positive pulmonary TB were detected before and after 2 months of intensive phase anti-TB treatment and compared with 50 cases from healthy volunteers (controls). The T lymphocyte cell population in peripheral blood was detected using flow cytometry...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29752313/schistosomiasis-induces-persistent-dna-methylation-and-tuberculosis-specific-immune-changes
#9
Andrew R DiNardo, Tomoki Nishiguchi, Emily M Mace, Kimal Rajapakshe, Godwin Mtetwa, Alexander Kay, Gugu Maphalala, W Evan Secor, Rojelio Mejia, Jordan S Orange, Cristian Coarfa, Kapil N Bhalla, Edward A Graviss, Anna M Mandalakas, George Makedonas
Epigenetic mechanisms, such as DNA methylation, determine immune cell phenotype. To understand the epigenetic alterations induced by helminth coinfections, we evaluated the longitudinal effect of ascariasis and schistosomiasis infection on CD4+ T cell DNA methylation and the downstream tuberculosis (TB)-specific and bacillus Calmette-Guérin-induced immune phenotype. All experiments were performed on human primary immune cells from a longitudinal cohort of recently TB-exposed children. Compared with age-matched uninfected controls, children with active Schistosoma haematobium and Ascaris lumbricoides infection had 751 differentially DNA-methylated genes, with 72% hypermethylated...
May 11, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29740435/a-beneficial-effect-of-low-dose-aspirin-in-a-murine-model-of-active-tuberculosis
#10
Vera Marie Kroesen, Paula Rodríguez-Martínez, Eric García, Yaiza Rosales, Jorge Díaz, Montse Martín-Céspedes, Gustavo Tapia, Maria Rosa Sarrias, Pere-Joan Cardona, Cristina Vilaplana
An excessive, non-productive host-immune response is detrimental in active, chronic tuberculosis (TB) disease as it typically leads to tissue damage. Given their anti-inflammatory effect, non-steroidal anti-inflammatory drugs can potentially attenuate excessive inflammation in active TB disease. As such, we investigated the prophylactic and therapeutic effect of low-dose aspirin (LDA) (3 mg/kg/day), either alone or in combination with common anti-TB treatment or BCG vaccination, on disease outcome in an experimental murine model of active TB...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29736404/-mycobacterium-tuberculosis-protein-rv3841-activates-dendritic-cells-and-contributes-to-a-t-helper-1-immune-response
#11
Seunga Choi, Han-Gyu Choi, Ki-Won Shin, Yong Woo Back, Hye-Soo Park, Jae Hwi Lee, Hwa-Jung Kim
The attenuated vaccine Mycobacterium bovis BCG (Bacille Calmette Guerin) has limited protective efficacy against TB. The development of more effective TB vaccines has focused on the mycobacterial antigens that cause strong T helper 1 (Th1) responses. Mtb protein Rv3841 (bacterioferritin B; BfrB) is known to play a crucial role in the growth of Mtb. Nonetheless, it is unclear whether Rv3841 can induce protective immunity against Mtb. Here, we studied the action of Rv3841 in maturation of dendritic cells (DCs) and its engagement in the development of T-cell immunity...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29721337/influence-of-seasonality-and-circulating-cytokines-on-serial-quantiferon-discordances
#12
Marsha L Griffin, Saroochi Agarwal, Melissa Zhu Murphy, Larry D Teeter, Edward A Graviss
Objectives. An 18-month prospective study serially tested healthcare workers (HCWs) for tuberculosis infection (TBI) and reported discordant QuantiFERON Gold In-Tube® (QFT) results in some participants. The purpose of the current study was to investigate whether the interferon-gamma (IFN- γ ) measured by QFT in discordant individuals could be influenced by other circulating cytokines that vary seasonally at the time of phlebotomy. Methods. The CDC funded TBESC Task Order 18 (TO18) project to assess the use of Interferon Gamma Release Assays (IGRAs), T-SPOT...
2018: Tuberculosis Research and Treatment
https://www.readbyqxmd.com/read/29697076/the-levels-of-pro-fibrotic-cytokines-in-pulmonary-tuberculosis-with-minimal-and-extensive-lesions
#13
Triwahju Astuti, Iin Noor Chozin, Nevy Shinta Damayanti, Dian Nugrahenny
Background: There are very few studies about the mechanism of fibrosis in tuberculosis (TB). This study aimed to determine the levels of tumor necrosis factor-α (TNF-α), insulin-like growth factor-1 (IGF-1), and transforming growth factor-β1 (TGF-β1) in pulmonary TB patients with minimal and extensive lesions. Materials and Methods: Cross-sectional observational study design was used to observe the pulmonary TB patients with minimal and extensive lesions, and also healthy controls, each consisting of ten patients...
May 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29686176/association-between-arg753gln-and-arg677trp-polymorphisms-of-tlr2-gene-with-active-pulmonary-tuberculosis-in-an-indonesian-population
#14
Arto Yuwono Soeroto, Zulkarnain Dahlan, Cissy B Kartasasmita, Ida Parwati
BACKGROUND: Toll-like receptor is a pattern recognition receptor (PRR) that recognize pathogen-associated molecular pattern (PAMP) in a microorganism. Macrophages recognize the presence of mycobacteria through Toll-Like Receptor 2 (TLR2) and signaling further lead to the production of cytokines, both proinflammatory TNF-α, IL-1β, IL-6, IL-12, IL-15, IL-18 and IFN-γ, as well as anti-inflammatory IL4, IL-10 and TGF-β. TLR2 gene polymorphism is strongly determined by ethnicity and geography...
January 2018: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29685203/evaluation-of-isoprinosine-to-be-repurposed-as-an-adjunct-anti-tuberculosis-chemotherapy
#15
Alok K Mishra, Shivraj M Yabaji, Rikesh K Dubey
Isoprinosine (Inos) or immunovir is a synthetic purine derivative with immune-modulatory and antiviral properties. The drug shows apparent in vivo enhancement of host immune responses by inducing pro-inflammatory cytokines and rapid proliferation of T-cell subsets. Strikingly, the cytokines induced by Inos also play crucial roles in providing immune resistance against Mycobacterium tuberculosis (Mtb). Inos has been licensed for several antiviral diseases; however, its efficacy against Mtb has not been tested yet...
June 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29685013/status-of-cathelicidin-il-37-cytokine-tnf-and-vitamin-d-in-patients-with-pulmonary-tuberculosis
#16
K Majewski, J Agier, E Kozłowska, E Brzezińska-Błaszczyk
Development of Mycobacterium tuberculosis (Mtb) infection depends on the ability of the host to elicit the protective immune response to the pathogen. Cathelicidin plays a role in antibacterial innate immunity mechanisms. This peptide contributes to the barrier function of respiratory epithelium and takes part in controlling pulmonary bacterial infections. LL-37 (leucine-leucine-37) is involved in host defense and innate immune response to mycobacterial infections, as well. This study aims to evaluate the serum concentrations of LL-37 in individuals with active pulmonary tuberculosis (TB) and to determine whether any correlations between peptide LL-37, tumor necrosis factor (TNF) and vitamin D serum levels exist...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29684756/modulation-of-th1-tc1-and-th17-tc17-responses-in-pulmonary-tuberculosis-by-il-20-subfamily-of-cytokines
#17
Nathella Pavan Kumar, Kadar Moideen, Vaithilingam V Banurekha, Dina Nair, Subash Babu
Although IL-10 is known to be an important cytokine in the immune response to TB, very little is known about the role of IL-20 subfamily of cytokines in the host response to TB. To identify the role of CD4+ T and CD8+ T cells producing IL-20 subfamily of cytokines in human TB, we enumerated the frequencies of IL-10, IL-19 and IL-24 expressing CD4+ and CD8+ T cells following Mtb-specific antigen stimulation of cells from individuals with pulmonary TB (PTB) and latent TB (LTB). We first demonstrated that Mtb-specific antigen induce an expansion of CD4+ and CD8+ T cells expressing IL-10, IL-19 and IL-24 in PTB and LTB individuals, with frequencies being significantly higher in PTB...
April 20, 2018: Cytokine
https://www.readbyqxmd.com/read/29670618/bcg-and-adverse-events-in-the-context-of-leprosy
#18
Renate Richardus, Anouk van Hooij, Susan J F van den Eeden, Louis Wilson, Korshed Alam, Jan Hendrik Richardus, Annemieke Geluk
Background: Notwithstanding its beneficial immunoprophylactic outcomes regarding leprosy and childhood TB, BCG vaccination may cause adverse events, particularly of the skin. However, this local hyper-immune reactivity cannot be predicted before vaccination, nor is its association with protection against leprosy known. In this study we investigated the occurrence of adverse events after BCG (re)vaccination in contacts of leprosy patients and analyzed whether the concomitant systemic anti-mycobacterial immunity was associated with these skin manifestations...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29625705/mycobacterium-tuberculosis-protein-rv2220-induces-maturation-and-activation-of-dendritic-cells
#19
Seunga Choi, Han-Gyu Choi, JaeHwi Lee, Ki-Won Shin, Hwa-Jung Kim
Tuberculosis remains a serious health problem worldwide. Characterization of the dendritic cell (DC)-activating mycobacterial proteins has driven the development of effective TB vaccine candidates besides improving the understanding of immune responses. Some studies have emphasized the essential role of protein Rv2220 from M. tuberculosis in mycobacterial growth. Nonetheless, little is known about cellular immune responses to Rv2220. In this study, our aim was to test whether protein Rv2220 induces maturation and activation of DCs...
March 31, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29625462/retinal-pigment-epithelial-cells-control-early-mycobacterium-tuberculosis-infection-via-interferon-signaling
#20
Rina La Distia Nora, Kimberley V Walburg, P Martin van Hagen, Sigrid M A Swagemakers, Peter J van der Spek, Edwin Quinten, Mirjam van Velthoven, Tom H M Ottenhoff, Willem A Dik, Mariëlle C Haks
Purpose: Mycobacterium tuberculosis (Mtb) bacilli have been found in retinal pigment epithelial (RPE) cells from uveitis patients without signs of systemic tuberculosis (TB) infection. RPE cells are important for ocular immune privilege and uveitis development. Methods: To address a potential role for Mtb-infected RPE cells in the development of uveitis, we delineated the response to Mtb infection in human RPE cells and primary human macrophages, the main target cell of Mtb...
March 1, 2018: Investigative Ophthalmology & Visual Science
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