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https://www.readbyqxmd.com/read/29348638/changes-in-cytokine-responses-to-tb-antigens-esat-6-cfp-10-and-tb-7-7-and-inflammatory-markers-in-peripheral-blood-during-therapy
#1
Ah Young Leem, Joo Han Song, Eun Hye Lee, Hyejon Lee, Bora Sim, Song Yee Kim, Kyung Soo Chung, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Joon Chang, Young Ae Kang
Multiple cytokines and inflammatory markers control TB infection. We aimed to investigate the changes in multiple cytokines and inflammatory markers in active TB patients following anti-TB drug therapy. Twenty-nine patients with active TB were recruited prospectively between December 2010 and July 2017. Blood samples were collected before (T0), after 2 months (T2), and at the end of anti-TB treatment (Tend). We measured the levels of Interferon (IFN)-γ, interleukin (IL)-2, IL-12, IL-10, IL-13 and tumor necrosis factor (TNF)-α in supernatants collected from the QuantiFERON-TB Gold In-Tube assay (QFT-GIT), as well as the WBC, neutrophil, platelet count and neutrophil to lymphocyte ratio (NLR) in whole blood...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29332642/current-affairs-future-perspectives-of-tuberculosis-and-antitubercular-agents
#2
REVIEW
Jineetkumar Gawad, Chandrakant Bonde
Tuberculosis (TB) is the major threat for humans from past several decades. Even after advent of several antitubercular drugs, researchers are still struggling for the mycobacterial infections in humans are TB and leprosy. Chronic infections caused by Mycobacterium tuberculosis and Mycobacterium leprae. A particular problem with both of these organisms is that they can survive inside macrophages after phagocytosis, unless these cells are activated by cytokines produced by T-lymphocytes, because of this researchers are not yet succeeded in finding effective treatment on TB...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29325881/rv2204c-rv0753c-and-rv0009-antigens-specific-t-cell-responses-in-latent-and-active-tb-a-flow-cytometry-based-analysis
#3
Balaji Pathakumari, Santhi Devasundaram, Prabhavathi Maddineni, Alamelu Raja
High global prevalence of latent TB infection (LTBI) is a key challenge in distinguishing patients with active pulmonary TB (PTB) from those with LTBI. The functional profile of CD4+ and CD8+ T cell cytokines produced as a response to Mycobacterium tuberculosis antigens vary during the course of tuberculosis (TB) infection. We evaluated antigen-specific CD4+ and CD8+ T cell cytokine response after overnight in vitro stimulation of peripheral blood with mycobacterial antigens ESAT-6, CFP-10, Rv2204c, Rv0753c and Rv0009 by flow cytometry...
December 6, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29311364/isg15-induced-il-10-is-a-novel-anti-inflammatory-myeloid-axis-disrupted-during-active-tuberculosis
#4
Paula Fernandes Dos Santos, Johan Van Weyenbergh, Murilo Delgobo, Daniel de Oliveira Patricio, Brian J Ferguson, Rodrigo Guabiraba, Tim Dierckx, Soraya Maria Menezes, André Báfica, Daniel Santos Mansur
IFN-stimulated gene 15 (ISG15) deficiency in humans leads to severe IFNopathies and mycobacterial disease, the latter being previously attributed to its extracellular cytokine-like activity. In this study, we demonstrate a novel role for secreted ISG15 as an IL-10 inducer, unique to primary human monocytes. A balanced ISG15-induced monocyte/IL-10 versus lymphoid/IFN-γ expression, correlating with p38 MAPK and PI3K signaling, was found using targeted in vitro and ex vivo systems analysis of human transcriptomic datasets...
January 8, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29311240/potential-immunological-biomarkers-for-detection-of-mycobacterium-tuberculosis-infection-in-endemic-setting-ethiopia
#5
Takele Teklu, Kwon Keehwan, Biniam Wondale, Milkessa HaileMariam, Mengistu Legesse, Girmay Medhin, Aboma Zewude, Rembert Pieper, Gobena Ameni
Accurate diagnosis and early treatment of tuberculosis (TB) and latent TB infection (LTBI) are vital to prevent and control TB. The lack of specific biomarkers hinders these efforts. This study's purpose was to screen immunological markers that discriminate M. tuberculosis (Mtb) infection outcomes in an endemic setting of Ethiopia. Whole blood from 90 participants was stimulated using the ESAT-6/CFP-10 antigen cocktail. The interferon-γ (IFN-γ)-based QuantiFERON diagnostic test was used to distinguish between LTBI and uninfected control cases...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29302700/immunization-with-an-adenovirus-vectored-tb-vaccine-containing-ag85a-mtb32-effectively-alleviates-allergic-asthma
#6
Yiling Zhang, Ying Feng, Liang Li, Xianmiao Ye, Jinlin Wang, Qian Wang, Pingchao Li, Na Li, Xuehua Zheng, Xiang Gao, Chufang Li, Feng Li, Baoqing Sun, Kefang Lai, Zhong Su, Nanshan Zhong, Ling Chen, Liqiang Feng
Current treatments for allergic asthma primarily ameliorate symptoms rather than inhibit disease progression. Regulating the excessive T helper type 2 (Th2) responses may prevent asthma exacerbation. In this study, we investigated the protective effects of Ad5-gsgAM, an adenovirus vector carrying two mycobacterial antigens Ag85A and Mtb32, against allergic asthma. Using an ovalbumin (OVA)-induced asthmatic mouse model, we found that Ad5-gsgAM elicited much more Th1-biased CD4+T and CD8+T cells than bacillus Calmette-Guérin (BCG)...
January 4, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29248507/potential-diagnostic-power-of-blood-circular-rna-expression-in-active-pulmonary-tuberculosis
#7
Zhongqing Qian, Hui Liu, Musheng Li, Junchao Shi, Na Li, Yao Zhang, Xiaojie Zhang, Jingzhu Lv, Xueying Xie, Yunfei Bai, Qinyu Ge, Eun-A Ko, Haiyang Tang, Ting Wang, Xiaojing Wang, Zhaohua Wang, Tong Zhou, Wanjun Gu
BACKGROUND: Circular RNAs (circRNAs) are a class of novel RNAs with important biological functions, and aberrant expression of circRNAs has been implicated in human diseases. However, the feasibility of using blood circRNAs as disease biomarkers is largely unknown. METHODS: We explored the potential of using human peripheral blood mononuclear cell (PBMC) circRNAs as marker molecules to diagnose active pulmonary tuberculosis (TB). FINDINGS: First, we demonstrated that circRNAs are widely expressed in human PBMCs and that many are abundant enough to be detected...
December 8, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29235156/ifn-%C3%AE-against-the-38-kda-antigen-of-mycobacterium-tuberculosis-discriminates-pulmonary-tuberculosis-from-infection-and-infection-from-exposure-evidence-from-a-study-of-human-population-in-a-high-endemic-setting
#8
Fekadu Abebe, Mulugeta Belay, Mengistu Legesse
Mycobacterium tuberculosis (Mtb) 38-kDa antigen is an immunogenic lipoprotein that induces strong T-cell responses in experimental animals. However, there is limited information on the role of this antigen in human population. In this article, we present the dynamics of pro-inflammatory (IFN-γ and TNF-α) and anti-inflammatory cytokine (IL-10) against the 38 kDa in cohorts of pulmonary TB (PTB) patients, household contacts (HHCs), and community controls (CCs) in a high endemic setting. Whole blood assay was used to determine the levels of cytokines in 149 patients, 149 HHCs, and 68 CCs at baseline, 6 months, and 12 months...
December 13, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29228365/notch4-negatively-regulates-the-inflammatory-response-to-mycobacterium-tuberculosis-infection-by-inhibiting-tak1-activation
#9
Ruijuan Zheng, Haipeng Liu, Yilong Zhou, Dapeng Yan, Jianxia Chen, Dapeng Ma, Yonghong Feng, Lianhua Qin, Feng Liu, Xiaochen Huang, Jie Wang, Baoxue Ge
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) infection remains a global threat to human health, but knowledge of the molecular mechanisms underlying the pathogenesis of TB is still limited. Although Notch4, a member of the Notch receptor family, is involved in the initiation of mammary tumors, its function in Mtb infection remains unclear. In this study, we found that Notch4-deficient mice were more resistant to Mtb infection with a much lower bacterial burden and less pathological changes in the lungs...
December 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29216277/immune-mediated-inflammatory-diseases-differently-affect-igras-accuracy-for-latent-tuberculosis-infection-diagnosis-in-clinical-practice
#10
Irene Latorre, Sonia Mínguez, José-Manuel Carrascosa, Juan Naves, Raquel Villar-Hernández, Beatriz Muriel, Cristina Prat, Esther García-García, Irma Casas, Eugeni Domènech, Carlos Ferrándiz, Lourdes Mateo, Jose Domínguez
BACKGROUND: Clinical accuracy of IGRAs remains unclear on patients with immune-mediated inflammatory diseases (IMIDs). Here, we assess the impact of immunosuppressants and IMIDs on QuantiFERON-TB Gold In-Tube (QFN-G-IT) and T-SPOT.TB accuracy. METHODS: Patients with IMIDs who required latent tuberculosis infection (LTBI) screening were enrolled and classified into: (i) 50 patients with inflammatory rheumatic diseases, (ii) 50 patients with psoriasis and (iii) 30 patients with Crohn's disease...
2017: PloS One
https://www.readbyqxmd.com/read/29210073/interleukin-17-regulates-matrix-metalloproteinase-activity-in-human-pulmonary-tuberculosis
#11
Shivani Singh, George Maniakis-Grivas, Utpal K Singh, Radha M Asher, Francesco Mauri, Paul T Elkington, Jon S Friedland
Tuberculosis (TB) is characterised by extensive pulmonary matrix breakdown. Interleukin-17 (IL-17) is key in host defence in TB but its role in TB-driven tissue damage is unknown. We investigated the hypothesis that respiratory stromal cell matrix metalloproteinase (MMP) production in TB is regulated by T helper-17 (TH -17) cytokines. Biopsies of patients with pulmonary TB were analysed by immunohistochemistry (IHC) and patient bronchoalveolar lavage fluid (BALF) MMP and cytokine concentrations measured by Luminex assays...
December 6, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/29208960/mif-173-g%C3%A2-%C3%A2-c-rs755622-gene-polymorphism-modulates-tuberculosis-risk-evidence-from-a-meta-analysis-and-trial-sequential-analysis
#12
Mohammed Y Areeshi, Raju K Mandal, Sajad A Dar, Arshad Jawed, Mohd Wahid, Mohtashim Lohani, Aditya K Panda, B N Mishra, Naseem Akhter, Shafiul Haque
The macrophage migration inhibitory factor (MIF) is a cytokine that plays an important role in inhibiting the growth of pathogenic Mycobacterium tuberculosis (M.tb) and regulates immune responses against M.tb pathogen. MIF -173 G > C gene polymorphism may affect immunity in an individual and leads to susceptibility to tuberculosis (TB). A large number of studies have investigated the relevance of this polymorphism with TB risk, but their results were inconclusive. To obtain a precise conclusion, a meta-analysis was performed by retrieving six eligible studies from Google Scholar, PubMed (Medline), and EMBASE online databases...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29204139/mycobacterium-tuberculosis-latent-antigen-rv2029c-from-the-multistage-dna-vaccine-a39-drives-th1-responses-via-tlr-mediated-macrophage-activation
#13
Haibo Su, Shengling Zhu, Lin Zhu, Cong Kong, Qi Huang, Zhi Zhang, Honghai Wang, Ying Xu
Targeting of Mycobacterium tuberculosis (MTB) latent antigens comprises a crucial strategy for the development of alternative tuberculosis (TB) vaccine(s) that protects against TB reactivation. Here, we generated a multistage DNA vaccine, A39, containing the early antigens Ag85A and Rv3425 as well as the latency-associated protein Rv2029c, which conferred protective immunity in a pre-exposure mouse model. Moreover, administration of the A39 vaccination after MTB exposure inhibited reactivation and resulted in significantly lower bacterial loads in the lungs and spleen of mice, compared to those in the control population...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29178041/cellular-immune-response-in-mdr-tb-patients-to-different-protein-expression-of-mdr-and-susceptible-mycobacterium-tuberculosis-rv0147-a-novel-mdr-tb-biomarker
#14
Alireza Hadizadeh Tasbiti, Shamsi Yari, Seyed Davar Siadat, Payam Tabarsi, Kayvan Saeedfar, Fatemeh Yari
Tuberculosis (TB) is a crucial public health problem with prevalence of multidrug resistant (MDR) rising. An accurate TB biomarker is urgently needed to monitor the response to treatment in patients with MDR tuberculosis. To analyze interaction between selected MDR-TB purified protein and immune cells, dendritic cells from MDR-TB patients and healthy subjects were stimulated by 55KDa protein fractions (Rv0147). The purified proteins identified by proteomic techniques (two-dimensional gel electrophoresis, mass spectrometry) and peptide sequences are known to bind a MHC class I alleles which are extracted from the Immune Epitope Database and Analysis Resource database ( www...
November 24, 2017: Immunologic Research
https://www.readbyqxmd.com/read/29176982/suppressor-of-cytokine-signaling-3-in-macrophages-prevents-exacerbated-interleukin-6-dependent-arginase-1-activity-and-early-permissiveness-to-experimental-tuberculosis
#15
Erik Schmok, Mahin Abad Dar, Jochen Behrends, Hanna Erdmann, Dominik Rückerl, Tanja Endermann, Lisa Heitmann, Manuela Hessmann, Akihiko Yoshimura, Stefan Rose-John, Jürgen Scheller, Ulrich Emil Schaible, Stefan Ehlers, Roland Lang, Christoph Hölscher
Suppressor of cytokine signaling 3 (SOCS3) is a feedback inhibitor of interleukin (IL)-6 signaling in macrophages. In the absence of this molecule, macrophages become extremely prone to an IL-6-dependent expression of arginase-1 (Arg1) and nitric oxide synthase (NOS)2, the prototype markers for alternative or classical macrophage activation, respectively. Because both enzymes are antipodean macrophage effector molecules in Mycobacterium tuberculosis (Mtb) infection, we assessed the relevance of SOCS3 for macrophage activation during experimental tuberculosis using macrophage-specific SOCS3-deficient (LysMcreSOCS3loxP/loxP) mice...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29176747/the-crucial-roles-of-th17-related-cytokines-signal-pathways-in-m-tuberculosis-infection
#16
REVIEW
Hongbo Shen, Zheng W Chen
Interleukin-17 (IL-17), IL-21, IL-22 and IL-23 can be grouped as T helper 17 (Th17)-related cytokines because they are either produced by Th17/Th22 cells or involved in their development. Here, we review Th17-related cytokines/Th17-like cells, networks/signals and their roles in immune responses or immunity against Mycobacterium tuberculosis (Mtb) infection. Published studies suggest that Th17-related cytokine pathways may be manipulated by Mtb microorganisms for their survival benefits in primary tuberculosis (TB)...
November 27, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29174965/il-6-release-of-rv0183-antigen-stimulated-whole-blood-is-a-potential-biomarker-for-active-tuberculosis-patients
#17
Yongliang Liu, Xiaofei Li, Wei Liu, Yang Liu, Zhouyue Zhong, Lili Wang, ShengXiang Ge, Jun Zhang, Ningshao Xia
OBJECTIVE: New tests for diagnosing active tuberculosis (aTB) are urgently needed, and TB antigen-specific cell-mediated immunity can be expected to develop new testing methods of aTB. MATERIALS AND METHODS: Rv0183 protein, the only monoglyceride lipase identified in mycobacteria, was used to stimulate freshly heparin-treated whole blood. The Rv0183-specific cytokines/chemokines response associated with aTB was screened firstly with 4 aTB patients and 4 LTBIs, and further evaluated in 192 suspected aTB patients and 372 healthy individuals...
November 24, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29163427/antimycobacterial-and-anti-inflammatory-mechanisms-of-baicalin-via-induced-autophagy-in-macrophages-infected-with-mycobacterium-tuberculosis
#18
Qingwen Zhang, Jinxia Sun, Yuli Wang, Weigang He, Lixin Wang, Yuejuan Zheng, Jing Wu, Ying Zhang, Xin Jiang
Tuberculosis (TB) remains a leading killer worldwide among infectious diseases and the effective control of TB is still challenging. Autophagy is an intracellular self-digestion process which has been increasingly recognized as a major host immune defense mechanism against intracellular microorganisms like Mycobacterium tuberculosis (Mtb) and serves as a key negative regulator of inflammation. Clinically, chronic inflammation surrounding Mtb can persist for decades leading to lung injury that can remain even after successful treatment...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29161328/use-of-quantiferon%C3%A2-tb-gold-in-tube-culture-supernatants-for-measurement-of-antibody-responses
#19
Simon G Kimuda, Irene Andia-Biraro, Moses Egesa, Bernard S Bagaya, John G Raynes, Jonathan Levin, Alison M Elliott, Stephen Cose
QuantiFERON®-TB Gold in-tube (QFT-GIT) supernatants may be important samples for use in assessment of anti-tuberculosis (TB) antibodies when only limited volumes of blood can be collected and when a combination of antibody and cytokine measurements are required. These analytes, when used together, may also have the potential to differentiate active pulmonary TB (APTB) from latent TB infection (LTBI). However, few studies have explored the use of QFT-GIT supernatants for investigations of antibody responses...
2017: PloS One
https://www.readbyqxmd.com/read/29151578/th1-cytokines-true-functional-signatures-for-protective-immunity-against-tb
#20
REVIEW
Gucheng Zeng, Guoliang Zhang, Xinchun Chen
The lack of an effective preventative vaccine against tuberculosis (TB) presents a great challenge to TB control. Since it takes an extremely long time to accurately determine the protective efficacy of TB vaccines, there is a great need to identify the surrogate signatures of protection to facilitate vaccine development. Unfortunately, antigen-specific Th1 cytokines that are currently used to evaluate the protective efficacy of the TB vaccine, do not align with the protection and failure of TB vaccine candidates in clinical trials...
November 20, 2017: Cellular & Molecular Immunology
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