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https://www.readbyqxmd.com/read/27892960/new-genome-wide-algorithm-identifies-novel-in-vivo-expressed-mycobacterium-tuberculosis-antigens-inducing-human-t-cell-responses-with-classical-and-unconventional-cytokine-profiles
#1
Mariateresa Coppola, Krista E van Meijgaarden, Kees L M C Franken, Susanna Commandeur, Gregory Dolganov, Igor Kramnik, Gary K Schoolnik, Inaki Comas, Ole Lund, Corine Prins, Susan J F van den Eeden, Gro E Korsvold, Fredrik Oftung, Annemieke Geluk, Tom H M Ottenhoff
New strategies are needed to develop better tools to control TB, including identification of novel antigens for vaccination. Such Mtb antigens must be expressed during Mtb infection in the major target organ, the lung, and must be capable of eliciting human immune responses. Using genome-wide transcriptomics of Mtb infected lungs we developed data sets and methods to identify IVE-TB (in-vivo expressed Mtb) antigens expressed in the lung. Quantitative expression analysis of 2,068 Mtb genes from the predicted first operons identified the most upregulated IVE-TB genes during in-vivo pulmonary infection...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27884382/profile-of-glycated-hemoglobin-antioxidant-vitamin-and-cytokine-levels-in-pulmonary-tuberculosis-patients-a-cross-sectional-study-at-pulmonary-diseases-center-semarang-city-indonesia
#2
Praba Ginandjar, Lintang Dian Saraswati, Bagoes Widjanarko
BACKGROUND: Uncontrolled blood glucose, which marked by high level of HbA1c, increases risk of pulmonary TB because of cellular immunity dysfunction. This study aimed to analyze profile of glycated hemoglobin, antioxidant vitamins status and cytokines levels in active pulmonary TB patients. METHODS: This was a cross sectional study, conducted at Pulmonary Diseases Center Semarang City, Indonesia. Study subject consisted of 62 pulmonary TB patients, diagnosed with positive acid fast bacilli and chest X-ray...
October 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27871809/biomarkers-for-discrimination-between-latent-tuberculosis-infection-and-active-tuberculosis-disease
#3
Eun-Jeong Won, Jung-Ho Choi, Young-Nan Cho, Hye-Mi Jin, Hae Jin Kee, Yong-Wook Park, Yong-Soo Kwon, Seung-Jung Kee
OBJECTIVE: We aimed to determine whether combinations of multiplex cytokine responses could differentiate Mycobacterium tuberculosis (Mtb) infection states. METHODS: Mtb-specific antigen-induced and unstimulated cytokines were measured by Luminex assay in supernatants of QuantiFERON(®) Gold In-Tube assay (QFT) in 48 active pulmonary TB patients (TB), 15 latent TB infection subjects (LTBI), and 13 healthy controls (HCs). RESULTS: Among the 29 cytokines, eight Mtb antigen-specific biomarkers (GM-CSF, IFN-γ, IL-1RA, IL-2, IL-3, IL-13, IP-10, and MIP-1β) in the Mtb-infected group were significantly different from those of the HCs...
November 19, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27865406/an-adverse-immune-endocrine-profile-in-patients-with-tuberculosis-and-type-2-diabetes
#4
R Fernández, A Díaz, L D'Attilio, B Bongiovanni, N Santucci, D Bertola, H Besedovsky, A Del Rey, M L Bay, O Bottasso
Diabetes is a risk factor for the development of pulmonary tuberculosis (TB) and both diseases present endocrine alterations likely to play a role in certain immuno-endocrine-metabolic associated disorders. Patients with TB, or with TB and type 2 diabetes (TB + T2DM) and healthy controls (HCo) were assessed for plasma levels of cortisol, dehydroepiandrosterone (DHEA), estradiol, testosterone, growth hormone (GH), prolactin, insulin-like growth factor-1 (IGF-1), cytokines (IL-6, IL-10, IFN-γ) and the specific lymphoproliferative capacity of peripheral blood mononuclear cells...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865399/high-body-mass-index-is-associated-with-heightened-systemic-and-mycobacterial-antigen-specific-pro-inflammatory-cytokines-in-latent-tuberculosis
#5
Rajamanickam Anuradha, Saravanan Munisankar, Yukthi Bhootra, Chandrakumar Dolla, Paul Kumaran, Subash Babu
High body mass index (HBMI) has been shown to be protective against active tuberculosis (TB), although the biological mechanism underlying this protection is poorly understood. The immunological association between HBMI and latent TB has never been examined. In order to study the association of HBMI with latent TB, we examined the circulating and TB- antigen or mitogen stimulated levels of a large panel of cytokines in individuals with latent TB (LTB) and high or normal body mass index (HBMI or NBMI). HBMI is characterized by heightened circulating levels of pro-inflammatory (IFNγ, TNFα, IL-22, IL-1α, IL-12 and GM-CSF) cytokines but decreased circulating levels of anti-inflammatory cytokines (IL-4, IL-5 and TGFβ)...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865392/mycobacterium-indicus-pranii-mip-mediated-host-protective-intracellular-mechanisms-against-tuberculosis-infection-involvement-of-tlr-4-mediated-signaling
#6
Shibali Das, Bidisha Paul Chowdhury, Avranil Goswami, Shabina Parveen, Junaid Jawed, Nishith Pal, Subrata Majumdar
Mycobacterium tuberculosis infection inflicts the disease Tuberculosis (TB), which is fatal if left untreated. During M. tuberculosis infection, the pathogen modulates TLR-4 receptor down-stream signaling, indicating the possible involvement of TLR-4 in the regulation of the host immune response. Mycobacterium indicus pranii (MIP) possesses immuno-modulatory properties which induces the pro-inflammatory responses via induction of TLR-4-mediated signaling. Here, we observed the immunomodulatory properties of MIP against tuberculosis infection...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865390/alternative-bcg-delivery-strategies-improve-protection-against-mycobacterium-tuberculosis-in-non-human-primates-protection-associated-with-mycobacterial-antigen-specific-cd4-effector-memory-t-cell-populations
#7
S Sharpe, A White, C Sarfas, L Sibley, F Gleeson, A McIntyre, R Basaraba, S Clark, G Hall, E Rayner, A Williams, P D Marsh, M Dennis
Intradermal (ID) BCG injection provides incomplete protection against TB in humans and experimental models. Alternative BCG vaccination strategies may improve protection in model species, including rhesus macaques. This study compares the immunogenicity and efficacy of BCG administered by ID and intravenous (IV) injection, or as an intratracheal mucosal boost (ID + IT), against aerosol challenge with Mycobacterium tuberculosis Erdman strain. Disease pathology was significantly reduced, and survival improved, by each BCG vaccination strategy, relative to unvaccinated animals...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865389/mycobacterium-indicus-pranii-as-a-booster-vaccine-enhances-bcg-induced-immunity-and-confers-higher-protection-in-animal-models-of-tuberculosis
#8
Mohd Saqib, Rahul Khatri, Bindu Singh, Ananya Gupta, Arvind Kumar, Sangeeta Bhaskar
BCG, the only approved vaccine protects against severe form of childhood tuberculosis but its protective efficacy wanes in adolescence. BCG has reduced the incidence of infant TB considerably in endemic areas; therefore prime-boost strategy is the most realistic measure for control of tuberculosis in near future. Mycobacterium indicus pranii (MIP) shares significant antigenic repertoire with Mtb and BCG and has been shown to impart significant protection in animal models of tuberculosis. In this study, MIP was given as a booster to BCG vaccine which enhanced the BCG mediated immune response, resulting in higher protection...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865378/development-of-immune-biomarkers-of-pulmonary-tuberculosis-in-a-rabbit-model
#9
Ali Dehnad, Resmi Ravindran, Selvakumar Subbian, Imran H Khan
Tuberculosis (TB) causes extensive morbidity and mortality worldwide with approximately 10 million new cases of active disease emerging mostly from a pool of two billion individuals latently infected with Mycobacterium tuberculosis (M. tb) every year. The underlying host immune responses that drive M. tb infection to active disease or latency are not well understood. We propose that identification and characterization of host immune biomarkers will be helpful to better understand the mechanisms that drive this process, and may, in addition, lead to the development of better diagnostic tools for TB...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27862137/t-cell-responses-and-regulation-and-the-impact-of-in-vitro-il-10-and-tgf-%C3%AE-modulation-during-treatment-of-active-tuberculosis
#10
Siri L Feruglio, Dag Kvale, Anne Ma Dyrhol-Riise
Mycobacterium tuberculosis (Mtb) is particularly challenging for the immune system being an intracellular pathogen, and a variety of T cell subpopulations are activated by the host defense mechanism. In the present study we investigated T cell responses and regulation in active TB patients with drug-sensitive Mtb (n=18) during 24 weeks of efficient anti-TB therapy. T cell activation, differentiation, regulatory T cell (Treg) subsets, Mtb induced T cell proliferation and in vitro IL-10 and TGF-β modulation were analysed by flow cytometry at baseline and after 8 and 24 weeks of therapy, while soluble cytokines in culture supernatants were analysed by a 9-plex Luminex assay...
November 18, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27861525/elevated-neopterin-levels-are-associated-with-increased-tuberculosis-risk-in-rheumatoid-arthritis-patients-with-quantiferon-conversion-during-biologic-therapy
#11
Der-Yuan Chen, Ju-Pi Li, Yi-Ming Chen, Tsai-Ling Liao, Hsin-Hua Chen, Chia-Wei Hsieh, Yea-Wen Yeh, Joung-Liang Lan
QuantiFERON-TB-Gold (QFT-G) conversion is frequently observed in rheumatoid arthritis (RA) patients receiving biologic therapy. However, there have not been any known biomarkers available for detecting tuberculosis (TB) in QFT-G converters. We aimed to evaluate clinical utility of cytokines/chemokines for detecting TB in patients with QFT-G conversion. Among a total of 227 RA patients who underwent QFT-G assay, 187 QFT-G-negative patients received biologic therapy without isoniazid prophylaxis. QFT-G assay was repeated at week 52 of biologic therapy or at the time of TB diagnosis...
2016: PloS One
https://www.readbyqxmd.com/read/27825050/fever-range-hyperthermia-inhibits-cells-immune-response-to-protein-bound-polysaccharides-derived-from-coriolus-versicolor-extract
#12
Małgorzata Pawlikowska, Tomasz Jędrzejewski, Jakub Piotrowski, Wiesław Kozak
The aim of the study was to explore whether fever-range hyperthermia (FRH) might enhance the anticancer and immunoregulatory activities of protein-bound polysaccharides (PBP), a class of fungus derived immunomodifiers used in the cancer adjuvant therapy. Blood lymphocytes and breast cancer cells (MCF-7) were cultured at 39.5°C in humidified atmosphere containing 5% CO2 for 2h. After rested at 37°C for 6h, the cells were treated with PBP extract at 100- and 300μg/ml concentration. After indicated time, the proliferative response was analyzed and cytokine mRNA expression assessment was performed by qRT-PCR...
November 5, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27803453/evaluation-of-proinflammatory-cytokines-and-adverse-events-in-healthy-volunteers-upon-inhalation-of-antituberculosis-drugs
#13
Teerapol Srichana, Chaveewan Ratanajamit, Siwasak Juthong, Tan Suwandecha, Nisa Laohapojanart, Petchawan Pungrassami, Alwar Ramanujam Padmavathi
Inhalation therapy is a promising drug delivery approach for tuberculosis treatment. However, there is always concern about the safety of the dosage form by inhalation as it may induce inflammation. Developing a new dosage form for inhalation must include tests for its safety especially for the tumor necrosis factor (TNF)-α and interleukine (IL)-1β. The safety of four anti-tuberculosis (anti-TB) drugs administered via inhalation was assessed in healthy volunteers. Four anti-TB drugs; isoniazid, rifampicin, pyrazinamide and levofloxacin were prepared as dry powder and evaluated for uniformity of delivered dose and in vitro drug deposition...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27800700/t-cell-exhaustion-in-tuberculosis-pitfalls-and-prospects
#14
Nargis Khan, Aurobind Vidyarthi, Mohammed Amir, Khurram Mushtaq, Javed Naim Agrewala
T-cells play an important role in immunity but when these cells are overexposed to specific antigens, their function may decline. This state is usually referred to as exhaustion and the T-cells show reduced proliferation and functions such as cytokine release. T-cell exhaustion has been observed in several cancers as well as in chronic infections such as tuberculosis (TB). In chronic Mycobacterium tuberculosis (Mtb) infection, T-cells may express the exhaustion phenotype and show a progressive loss of secretion of IL-2, IFN-γ and TNF-α...
November 1, 2016: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/27799930/increased-tnf-%C3%AE-ifn-%C3%AE-il-2-and-decreased-tnf-%C3%AE-ifn-%C3%AE-production-by-central-memory-t-cells-are-associated-with-protective-responses-against-bovine-tuberculosis-following-bcg-vaccination
#15
Mayara F Maggioli, Mitchell V Palmer, Tyler C Thacker, Hans Martin Vordermeier, Jodi L McGill, Adam O Whelan, Michelle H Larsen, William R Jacobs, W Ray Waters
Central memory T cell (Tcm) and polyfunctional CD4 T cell responses contribute to vaccine-elicited protection with both human and bovine tuberculosis (TB); however, their combined role in protective immunity to TB is unclear. To address this question, we evaluated polyfunctional cytokine responses by CD4 T cell effector/memory populations from bacille Calmette-Guerin (BCG) vaccinated and non-vaccinated calves by flow cytometry prior to and after aerosol challenge with virulent Mycobacterium bovis. Polyfunctional cytokine expression patterns in the response by Tcm, effector memory, and effector T cell subsets were similar between BCG-vaccinated and M...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27794266/reduced-systemic-and-mycobacterial-antigen-stimulated-concentrations-of-il-1%C3%AE-and-il-18-in-tuberculous-lymphadenitis
#16
Gokul Raj Kathamuthu, Kadar Moideen, Dhanaraj Bhaskaran, Gomathi Sekar, Rathinam Sridhar, Bharathi Vidyajayanthi, Ganeshan Gajendraraj, Subash Babu
BACKGROUND: Type 1, Type 17 and other pro-inflammatory cytokines are known to play an important role in resistance to pulmonary tuberculosis. The role of these cytokines in tuberculous lymphadenitis (TBL) is not well characterized. METHODS: To estimate the systemic and mycobacterial antigen - stimulated cytokine concentrations of Type 1, Type 17, other pro-inflammatory and regulatory cytokines in TBL, we examined both the systemic and the antigen-specific concentrations of these cytokines in TBL (n=31) before and after chemotherapy, and compared them with those with latent tuberculosis infection (LTB, n=31)...
October 26, 2016: Cytokine
https://www.readbyqxmd.com/read/27789724/selective-destruction-of-il-23-induced-expansion-of-major-antigen-specific-%C3%AE-%C3%AE-t-cell-subset-in-tb-patients
#17
Hongbo Shen, Jin Gu, Shanshan Liang, Enzhuo Yang, Rui Yang, Dan Huang, Crystal Chen, Feifei Wang, Heping Xiao, Ling Shen, Zheng W Chen
A loss of antigen (Ag)-specific T-cell responses due to defective cytokine signaling during infections has not been reported. We hypothesize that tuberculosis (TB) can destroy signaling effects of selective cytokine(s), and induce exhaustion of Ag-specific T cells. To test this hypothesis, mechanistic studies were performed to examine whether and how TB blocked IL-23 and IL-2 signaling effects on a major human γδ T-cell subpopulation, phosphoantigen (HMBPP)-specific Vγ2Vδ2 T cells. IL-23 and IL-2 significantly expanded HMBPP-stimulated Vγ2Vδ2 T cells from subjects with latent TB infection, and IL-2 synergized IL-23 effect...
October 26, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27776487/the-cox-inhibitor-indomethacin-reduces-th1-effector-and-t-regulatory-cells-in-vitro-in-mycobacterium-tuberculosis-infection
#18
Kristian Tonby, Ida Wergeland, Nora V Lieske, Dag Kvale, Kjetil Tasken, Anne M Dyrhol-Riise
BACKGROUND: Tuberculosis (TB) causes a major burden on global health with long and cumbersome TB treatment regimens. Host-directed immune modulating therapies have been suggested as adjunctive treatment to TB antibiotics. Upregulated cyclooxygenase-2 (COX-2)-prostaglandin E2 (PGE2) signaling pathway may cause a dysfunctional immune response that favors survival and replication of Mycobacterium tuberculosis (Mtb). METHODS: Blood samples were obtained from patients with latent TB (n = 9) and active TB (n = 33) before initiation of anti-TB chemotherapy...
October 24, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27773800/in-vitro-and-in-vivo-antimycobacterial-hepatoprotective-and-immunomodulatory-activity-of-euclea-natalensis-and-its-mode-of-action
#19
Namrita Lall, Vivek Kumar, Debra Meyer, Nomasomi Gasa, Chris Hamilton, Motlalepula Matsabisa, Carel Oosthuizen
ETHNOPHARMACOLOGICAL RELEVANCE: The Natal gwarri or Natal ebony (Euclea natalensis A.DC.) is a deciduous tree found widespread throughout southern Africa, especially in Kwazulu-Natal and the southern cost. It has been widely used by indigenous communities such as the Zulus, Tsongas and Vendas for symptoms related to tuberculosis (TB). The decoctions made from the plant parts are administered for chest diseases to treat complications such as chest pains, bronchitis, pleurisy and asthma...
October 20, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27768958/impaired-toll-like-receptor-9-response-in-pulmonary-tuberculosis
#20
Kartik Ramakrishna, Kalpana Premkumar, Jayakanthan Kabeerdoss, K R John
BACKGROUND & AIM: Innate immune responses are important in susceptibility to pulmonary tuberculosis (TB). In order to test the hypothesis that Toll-like receptor (TLR) 2 function would be abnormal in patients with active pulmonary TB we compared the cytokine responses of peripheral blood mononuclear cells (PBMC) to innate immune ligands in a case-control study. METHODS: PBMC from 19 untreated pulmonary TB patients, 17 healthy controls, and 11 treated pulmonary TB patients, were cultured for 24h with TLR 2 ligand (PAM-CSK) and other TLR ligands (muramyl dipeptide, flagellin, lipopolysaccharide (LPS), CpG oligodeoxynucleotide (CpG-ODN))...
October 18, 2016: Cytokine
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