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Nontuberculous mycobacterium infection

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https://www.readbyqxmd.com/read/28547728/the-protective-effect-of-a-novel-antioxidant-gene-from-mycobacterium-avium-against-nitrosative-and-oxidative-stress-in-e-coli
#1
Shiyi He, Aiyan Wang, Xueping Ning, Dongjun Yang, Min Ling
The production of reactive oxygen intermediates (ROI) and reactive nitrogen intermediates (RNI) is an important host defense mechanism in response to infection by Mycobacterium tuberculosis. A variety of genes have been implicated in resistance to ROI and RNI, including noxR1. However, studies in Mycobacterium avium, an important pathogen among nontuberculous mycobacteria, are limited. We aim to investigate the role of a novel gene cloned from M. avium with high similarity to noxR1, noA, in resistance against RNI and ROI in M...
June 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28526906/mycobacterium-chelonae-infection-of-the-buttocks-secondary-to-lipofilling-a-case-report-and-review-of-the-literature
#2
Sarah E Hammond, Ahmed Al-Bayati, Natalie Joumblat, Christopher J Salgado
Mycobacterium chelonae is a nontuberculous mycobacterium, classified as a Runyon type IV mycobacterium. In relation to humans, it is most commonly associated with tissue trauma or pulmonary infections. The majority of medical reports describe finding M. chelonae in the surgical setting, attributing infection to inadequate sterilization of surgical equipment. Symptoms are often nonspecific and include pain, erythema, and draining subcutaneous nodules and skin lesions. Therefore, the diagnosis of M. chelonae is often difficult to establish without prior suspicion of the disease, but can be confirmed with culture...
May 19, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28521627/disseminated-bacillus-calmette-gu%C3%A3-rin-osteomyelitis-in-twin-sisters-related-to-stat1-gene-deficiency
#3
Sabah Boudjemaa, Linda Dainese, Sébastien Héritier, Caroline Masserot, Samia Hachemane, Jean-Laurent Casanova, Aurore Coulomb, Jacinta Bustamante
Mendelian susceptibility to mycobacterial disease is a rare syndrome characterized by severe clinical infections usually caused by weakly virulent mycobacterial species such as Bacillus Calmette-Guérin vaccines and environmental nontuberculous mycobacteria or more virulent mycobacteria as mycobacterium tuberculosis. Since 1996, 9 genes including 7 autosomal ( STAT1, IFNGR1, IFNGR2, IL12B, IL12RB1, ISG15, and IRF8) and 2 X-linked genes ( NEMO and CYBB) have been identified. Allelic heterogeneity leaded to recognize about 18 genetic diseases with variable clinical phenotypes, but sharing a same physiological mechanism represented by a defect in human IL-12-dependant-INF-γ-mediated immunity...
June 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28504926/accurate-differentiation-of-mycobacterium-chimaera-from-mycobacterium-intracellulare-by-maldi-tof-ms-analysis
#4
Arthur B Pranada, Ellen Witt, Michael Bienia, Markus Kostrzewa, Markus Timke
PURPOSE: The increasing number of infections caused by nontuberculous mycobacteria (NTM) has prompted the need for rapid and precise identification methods of these pathogens. Several studies report the applicability of MALDI-TOF mass spectrometry (MS) for identification of NTM. However, some closely related species have very similar spectral mass fingerprints, and until recently, Mycobacterium chimaera and M. intracellulare could not be separated from each other by MALDI-TOF MS. METHODOLOGY: The conventional identification methods used in routine diagnostics have similar limitations...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28502947/intractable-cutaneous-nontuberculous-mycobacteriosis-mycobacterium-abscessus-during-treatment-for-systemic-lupus-erythematosus
#5
Dai Kishida, Mitsuto Sato, Chinatsu Kobayashi, Ken-Ichi Ueno, Tomomi Kinoshita, Minori Kodaira, Yasuhiro Shimojima, Wataru Ishii, Atsuhito Ushiki, Shu-Ichi Ikeda
Mycobacterium abscessus infection tends to occur in patients with an advanced immunocompromised status. We encountered a case of intractable cutaneous M. abscessus infection that developed in a patient with systemic lupus erythematosus (SLE) during maintenance therapy. A 28-year-old woman developed a fever and redness of the skin on her buttocks. General antibacterial therapy was ineffective, and acid-fast bacteria were detected in the biopsy that was conducted to differentiate the dermal symptoms of SLE. The clinical findings eventually improved; however, the symptoms recurred multiple times during treatment...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28479113/pharmacotherapy-for-non-cystic-fibrosis-bronchiectasis-results-from-an-ntm-info-research-patient-survey-and-the-bronchiectasis-and-ntm-research-registry
#6
E Henkle, T R Aksamit, A F Barker, J R Curtis, C L Daley, M L Daniels, A DiMango, E Eden, K Fennelly, D E Griffith, M Johnson, M R Knowles, A Leitman, P Leitman, E Malanga, M L Metersky, P G Noone, A E O'Donnell, K N Olivier, D Prieto, M Salathe, B Thomashow, G Tino, G Turino, S Wisclenny, K L Winthrop
PURPOSE: Non-cystic fibrosis bronchiectasis ("bronchiectasis") is a chronic inflammatory lung disease often associated with nontuberculous mycobacterium (NTM) infection. Very little data exist to guide bronchiectasis management decisions. We sought to describe patterns of inhaled corticosteroid (ICS) and antibiotic therapy in the U.S. METHODS: We invited 2,000 patients through NTM Info & Research (NTMir) to complete an anonymous electronic survey. We separately queried baseline clinical and laboratory data from the U...
May 4, 2017: Chest
https://www.readbyqxmd.com/read/28471978/septicemia-and-pneumonia-due-to-mycobacterium-fortuitum-infection-in-a-patient-with-extronodal-nk-t-cell-lymphoma-nasal-type-a-case-report
#7
Jia Cong, Chenxi Wang, Li Ma, Shaoya Zhang, Jingwen Wang
RATIONALE: Mycobacterium fortuitum (M.fortuitum) is one of the rapidly growing nontuberculous mycobacterium (NTM) that is widespread in the environment. M.fortuitum can cause different types of disease including pulmonary disease, lymphadenitis, cutaneous disease, and disseminated disease. However, the infection presenting as septicemia is exceedingly rare. PATIENT CONCERNS: A 48-year-old immunocompromised male with extranodal NK/T-cell lymphoma, nasal type was admitted to the hospital because of high fever for 10 days...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28462746/disinfectant-susceptibility-profiling-of-glutaraldehyde-resistant-nontuberculous-mycobacteria
#8
Winona Burgess, Alyssa Margolis, Sara Gibbs, Rafael Silva Duarte, Mary Jackson
OBJECTIVE Activated alkaline glutaraldehyde (GTA) remains one of the most widely used high-level disinfectants worldwide. However, several reports have highlighted the potential for nontuberculous mycobacteria to develop high-level resistance to this product. Because aldehyde resistance may lead to cross-resistance to other biocides, we investigated the susceptibility profile of GTA-resistant Mycobacterium chelonae and M. abscessus isolates to various disinfectant chemistries. METHODS High-level disinfectants commonly used in the reprocessing of endoscopes and other heat-sensitive, semicritical medical equipment, including different formulations of aldehyde-based products and oxidizing agents, were tested against 10 slow- and fast-growing, GTA-susceptible and GTA-resistant, Mycobacterium isolates in suspension tests and carrier tests at different temperatures...
May 2, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28428296/complete-genome-sequences-of-mycobacterium-kansasii-strains-isolated-from-rhesus-macaques
#9
Aruna Panda, Sushma Nagaraj, Xuechu Zhao, Hervé Tettelin, Louis J DeTolla
Mycobacterium kansasii is a nontuberculous mycobacterium. It causes opportunistic infections with pulmonary and extrapulmonary manifestations. We report here the complete genome sequences of two M. kansasii strains isolated from rhesus macaques. We performed genome comparisons with human and environmental isolates of M. kansasii to assess the genomic diversity of this species.
April 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28422754/mpeg1-perforin-2-mutations-in-human-pulmonary-nontuberculous-mycobacterial-infections
#10
Ryan M McCormack, Eva P Szymanski, Amy P Hsu, Elena Perez, Kenneth N Olivier, Eva Fisher, E Brook Goodhew, Eckhard R Podack, Steven M Holland
Perforin-2 is a highly conserved pore-forming protein encoded by macrophage expressed gene 1 (MPEG1). A number of studies have shown that Perforin-2-deficient mice are unable to survive following a bacterial challenge that is nonlethal in WT mice. There is also recent evidence that Mpeg1+/- heterozygous mice display an intermediate killing ability compared with Mpeg1 WT and Mpeg1-/- mice. Despite these in vivo findings, to date, no perforin-2 deficiencies have been associated with human disease. Here, we report four patients with persistent nontuberculous mycobacterial infection who had heterozygous MPEG1 mutations...
April 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28422568/cgas-sting-tbk1-irf3-7-induced-interferon-%C3%AE-contributes-to-the-clearing-of-non-tuberculous-mycobacterial-infection-in-mice
#11
Nanthapon Ruangkiattikul, Andreas Nerlich, Ketema Abdissa, Stefan Lienenklaus, Abdulhadi Suwandi, Nina Janze, Kristin Laarmann, Julia Spanier, Ulrich Kalinke, Siegfried Weiss, Ralph Goethe
Type I interferons (IFN-I), such as IFN-α and IFN-β are important messengers in the host response against bacterial infections. Knowledge about the role of IFN-I in infections by nontuberculous mycobacteria (NTM) is limited. Here we show that macrophages infected with pathogens of the Mycobacterium avium complex produced significantly lower amounts of IFN-β than macrophages infected with the opportunistic pathogen M. smegmatis. To dissect the molecular mechanisms of this phenomenon, we focused on the obligate pathogen Mycobacterium avium ssp paratuberculosis (MAP) and the opportunistic M...
April 19, 2017: Virulence
https://www.readbyqxmd.com/read/28418290/invasive-nontuberculous-mycobacterial-infections-among-cardiothoracic-surgical-patients-exposed-to-heater-cooler-devices-1
#12
Meghan M Lyman, Cheri Grigg, Cara Bicking Kinsey, M Shannon Keckler, Heather Moulton-Meissner, Emily Cooper, Minn M Soe, Judith Noble-Wang, Allison Longenberger, Shane R Walker, Jeffrey R Miller, Joseph F Perz, Kiran M Perkins
Invasive nontuberculous mycobacteria (NTM) infections may result from a previously unrecognized source of transmission, heater-cooler devices (HCDs) used during cardiac surgery. In July 2015, the Pennsylvania Department of Health notified the Centers for Disease Control and Prevention (CDC) about a cluster of NTM infections among cardiothoracic surgical patients at 1 hospital. We conducted a case-control study to identify exposures causing infection, examining 11 case-patients and 48 control-patients. Eight (73%) case-patients had a clinical specimen identified as Mycobacterium avium complex (MAC)...
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28403059/mycobacterium-gordonae-skin-infection-in-an-immunocompetent-child
#13
Bridget Freyne, Nigel Curtis
Mycobacterium gordonae is a slow growing, pigmented, nontuberculous mycobacterium. It is commonly associated with environmental contamination of clinical specimens, but it is also a recognized pathogen in immunocompromised hosts. We describe an immunocompetent child with a spontaneously occurring skin ulcer on the face caused by M. gordonae infection.
May 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28400668/nontuberculous-mycobacterial-infection-of-the-musculoskeletal-system-in-immunocompetent-hosts
#14
Manit K Gundavda, Hitendra G Patil, Vikas M Agashe, Rajeev Soman, Camilla Rodriques, Ramesh B Deshpande
BACKGROUND: Nontuberculous mycobacteria (NTM) were considered saprophytic organisms for many years but now are recognized as human pathogens. Although humans are routinely exposed to NTM, the rate of clinical infection is low. Such infections usually occur in the elderly and in patients who are immunocompromised. However, there has been an increasing incidence in recent years of infections in immunocompetent hosts. NTM infections in immunocompetent individuals are secondary to direct inoculation either contamination from surgical procedures or penetrating injuries rather than hematogenous dissemination...
March 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28393860/mycobacterium-llatzerense-a-waterborne-mycobacterium-that-resists-phagocytosis-by-acanthamoeba-castellanii
#15
Vincent Delafont, Ascel Samba-Louaka, Emmanuelle Cambau, Didier Bouchon, Laurent Moulin, Yann Héchard
Nontuberculous mycobacteria (NTM) are environmental bacteria increasingly associated to public health problems. In water systems, free-living amoebae (FLA) feed on bacteria by phagocytosis, but several bacteria, including many NTM, are resistant to this predation. Thus, FLA can be seen as a training ground for pathogenic bacteria. Mycobacterium llatzerense was previously described as frequently associated with FLA in a drinking water network. The present study aimed to characterize the interactions between M...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28387532/mortality-after-respiratory-isolation-of-nontuberculous-mycobacteria-a-comparison-of-patients-who-did-and-did-not-meet-disease-criteria
#16
Shannon A Novosad, Emily Henkle, Sean Schafer, Katrina Hedberg, Jennifer Ku, Sarah A R Siegel, Dongseok Choi, Christopher G Slatore, Kevin L Winthrop
RATIONALE: The mortality of patients with respiratory tract isolates of nontuberculous mycobacteria (NTM) and their risk factors for death are not well described . OBJECTIVES: This study had two objectives: 1) to determine age-adjusted mortality rates for patients with respiratory NTM isolates and their causes of death; and 2) to examine whether ATS/IDSA diagnostic criteria identify those at higher risk of death after NTM isolation. METHODS: We linked vital records registries with a previously identified Oregon populationbased cohort of patients with NTM respiratory isolation...
April 7, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28387180/mycobacterium-marinum
#17
Alexandra Aubry, Faiza Mougari, Florence Reibel, Emmanuelle Cambau
Mycobacterium marinum is a well-known pathogenic mycobacterium for skin and soft tissue infections and is associated with fishes and water. Among nontuberculous mycobacteria (NTM), it is the leading cause of extrarespiratory human infections worldwide. In addition, there is a specific scientific interest in M. marinum because of its genetic relatedness to Mycobacterium tuberculosis and because experimental infection of M. marinum in fishes mimics tuberculosis pathogenesis. Microbiological characteristics include the fact that it grows in 7 to 14 days with photochromogenic colonies and is difficult to differentiate from Mycobacterium ulcerans and other mycolactone-producing NTM on a molecular basis...
April 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28387146/pinpointing-the-source-of-infection-of-mycobacterium-avium-hominissuis-in-children
#18
Johanna Thegerström
Mycobacterium avium hominissuis is the most important causative agent of chronic nontuberculous lymphadenitis in children. Despite a ubiquitous occurrence of the bacteria in the environment, the disease is a rare entity, and so far no source of infection has been formally identified. The current state of knowledge regarding possible sources of M. avium hominissuis, especially where children are concerned, is summarized here. An analysis of the seasonal variation of M. avium lymphadenitis in children leads to a new hypothesis regarding the probable source of infection of M...
April 7, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28350331/novel-sulfamethoxazole-ureas-and-oxalamide-as-potential-antimycobacterial-agents
#19
Martin Krátký, Jiřina Stolaříková, Jarmila Vinšová
Infections caused by Mycobacterium tuberculosis (Mtb.) and nontuberculous mycobacteria (NTM) are considered to be a global health problem; current therapeutic options are limited. Sulfonamides have exhibited a wide range of biological activities including those against mycobacteria. Based on the activity of 4-(3-heptylureido)-N-(5-methylisoxazol-3-yl)benzenesulfonamide against NTM, we designed a series of homologous sulfamethoxazole-based n-alkyl ureas (C₁-C12), as well as several related ureas and an oxalamide...
March 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28346488/comparison-of-chest-ct-findings-in-nontuberculous-mycobacterial-diseases-vs-mycobacterium-tuberculosis-lung-disease-in-hiv-negative-patients-with-cavities
#20
Cherry Kim, So Hee Park, Sang Young Oh, Sung-Soo Kim, Kyung-Wook Jo, Tae Sun Shim, Mi Young Kim
OBJECTIVES: This article focuses on the differences between CT findings of HIV-negative patients who have cavities with nontuberculous mycobacteria (NTM) disease and those with Mycobacterium tuberculosis infections (TB). METHODS: We retrospectively reviewed 128 NTM disease patients (79 males and 49 females) with cavities in chest CT, matched for age and gender with 128 TB patients in the same period. Sputum cultures of all patients were positive for pathogens. Two independent chest radiologists evaluated the characteristics of the largest cavity and related factors...
2017: PloS One
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