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Nontuberculous mycobacterium infection

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https://www.readbyqxmd.com/read/29791556/clinical-aspects-in-patients-with-pulmonary-infection-caused-by-mycobacteria-of-the-mycobacterium-abscessus-complex-in-the-brazilian-amazon
#1
José Tadeu Colares Monteiro, Karla Valéria Batista Lima, Adriana Rodrigues Barretto, Ismari Perini Furlaneto, Glenda Moraes Gonçalves, Ana Roberta Fusco da Costa, Maria Luiza Lopes, Margareth Pretti Dalcolmo
OBJECTIVE: To describe the clinical manifestations of patients with pulmonary infection caused by mycobacteria of the Mycobacterium abscessus complex (MABSC), and to compare these manifestations with those of patients infected with other nontuberculous mycobacteria (NTM). METHODS: This was a retrospective cohort study involving 43 patients divided into two groups: the MABSC group, consisting of patients with pulmonary infection caused by MABSC (n = 17); and the NTM group, consisting of patients with pulmonary infection caused by NTM other than MABSC (n = 26)...
April 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29788939/nontuberculous-mycobacteria-infection-and-lung-transplantation-in-cystic-fibrosis-a-worldwide-survey-of-clinical-practice
#2
Adrien Tissot, Matthew F Thomas, Paul A Corris, Malcolm Brodlie
BACKGROUND: In people with cystic fibrosis infection with NonTuberculous Mycobacteria is of increasing prevalence. Mycobacterium abscessus complex is of particular concern and has been associated with adverse clinical outcomes. Optimal treatment usually requires multiple antibiotics for over 12 months. When considering lung transplantation for patients with NonTuberculous Mycobacteria potential benefits must be balanced against the risks of uncontrolled infection post-transplant and significant side-effects associated with treatment...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29774836/pulmonary-infections-with-nontuberculous-mycobacteria-catalonia-spain-1994-2014
#3
Miguel Santin, Irene Barrabeig, Pierre Malchair, Lucia Gonzalez-Luquero, Miguel A Benitez, Josefina Sabria, Merce Palau-Benavent, Concepcion Cañete, Joan A Lloret-Queraltó, Maria D Grijota-Camino, Jordi Dorca, Fernando Alcaide
In Spain, systematic reporting of pulmonary infections with nontuberculous mycobacteria is not mandatory. Therefore, to determine trends, we retrospectively identified cases for January 1994-December 2014 in Catalonia. Over the 21 years, prevalence increased and was associated with being male. Mycobacterium avium complex and M. abscessus prevalence increased; M. kansasii prevalence decreased.
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29773279/-non-tuberculous-mycobacterial-cervical-adenitis-in-children-2-cases
#4
N Sigg, S Bailleul, J-M Turmel, G Legrand, S Kettani, L Martin
BACKGROUND: Cervical lymphadenitis is the most common manifestation of infection with nontuberculous mycobacteria (NTM) in immunocompetent children. Nevertheless, it is poorly known by dermatologists. Its incidence, which is currently increasing since the cessation of BCG vaccination in 2007, raises several issues regarding its pathophysiology, diagnosis and management. PATIENTS AND METHODS: We report two cases of NTM adenitis: one in a 2-year-old girl vaccinated with BCG and one in an unvaccinated 22-month-old boy, in whom a misleading presentation led to delayed diagnosis...
May 14, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29772918/cutaneous-nontuberculous-mycobacterial-infections-in-alberta-canada-an-epidemiologic-study-and-review
#5
Megan A Sander, Judith L Isaac-Renton, Gregory J Tyrrell
BACKGROUND: Cutaneous infections caused by nontuberculous mycobacteria (NTM) occur infrequently. Nonetheless, the incidence of NTM infections is reported to be increasing. In Canada, cutaneous NTM infections have not been well described. OBJECTIVES: A database review from 2006 to 2016 was done to assess species frequency, incidence, and trends of the most common cutaneous NTMs in the province of Alberta, Canada. We also reviewed major diagnostic and epidemiologic aspects of NTM cutaneous infections with a focus on Mycobacterium marinum...
May 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29760130/-mycobacterium-simiae-clinical-radiological-and-microbiological-characteristics-in-97-patients
#6
Nathalie Coolen-Allou, Thomas Touron, Olivier Belmonte, Virgile Gazaille, Michel Andre, Jérôme Allyn, Sandrine Picot, Annabelle Payet, Nicolas Veziris
Mycobacterium simiae is a rare species of slow-growing nontuberculous mycobacteria (NTM).From 2002 to 2017, we conducted a retrospective study that included all patients with NTM-positive respiratory samples detected in two university hospitals of the French overseas department of Reunion Island. We recorded the prevalence of M. simiae in this cohort, as well as the clinical, radiological, and microbiological features of patients with at least one sample positive for M. simiae In our cohort, 97 patients (15...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29712930/mycobacterium-marinum-infections-in-denmark-from-2004-to-2017-a-retrospective-study-of-incidence-patient-characteristics-treatment-regimens-and-outcome
#7
Inge K Holden, Michala Kehrer, Aase B Andersen, Christian Wejse, Erik Svensson, Isik Somuncu Johansen
Mycobacterium marinum (M. marinum) is a slowly growing nontuberculous mycobacterium. The incidence of M. marinum infections in Denmark is unknown. We conducted a retrospective nationwide study including all culture confirmed cases of M. marinum from 2004 to 2017 in Denmark. All available medical records were reviewed. Demographics, clinical characteristics, and treatment regiments were analyzed. Fifty-five patients were identified, 40 (72.7%) were men with a median age of 50 years. Aquatic exposure was reported by 48 (90...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29679902/new-lipophilic-isoniazid-derivatives-and-their-1-3-4-oxadiazole-analogues-synthesis-antimycobacterial-activity-and-investigation-of-their-mechanism-of-action
#8
Rudolf Vosátka, Martin Krátký, Markéta Švarcová, Jiří Janoušek, Jiřina Stolaříková, Jan Madacki, Stanislav Huszár, Katarína Mikušová, Jana Korduláková, František Trejtnar, Jarmila Vinšová
The development of novel drugs is essential for the treatment of tuberculosis and other mycobacterial infections in future. A series of N-alkyl-2-isonicotinoylhydrazine-1-carboxamides was synthesized from isoniazid (INH) and then cyclized to N-alkyl-5-(pyridin-4-yl)-1,3,4-oxadiazole-2-amines. All derivatives were characterised spectroscopically. The compounds were screened for their in vitro antimycobacterial activity against susceptible and multidrug-resistant Mycobacterium tuberculosis (Mtb.) and nontuberculous mycobacteria (NTM; M...
April 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29675789/experimental-platform-utilising-melting-curve-technology-for-detection-of-mutations-in-mycobacterium-tuberculosis-isolates
#9
Agnieszka Broda, Vlad Nikolayevskyy, Nicki Casali, Huma Khan, Richard Bowker, Gemma Blackwell, Bhakti Patel, James Hume, Waqar Hussain, Francis Drobniewski
Tuberculosis (TB) remains one of the most deadly infections with approximately a quarter of cases not being identified and/or treated mainly due to a lack of resources. Rapid detection of TB or drug-resistant TB enables timely adequate treatment and is a cornerstone of effective TB management. We evaluated the analytical performance of a single-tube assay for multidrug-resistant TB (MDR-TB) on an experimental platform utilising RT-PCR and melting curve analysis that could potentially be operated as a point-of-care (PoC) test in resource-constrained settings with a high burden of TB...
April 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29672589/neutrophil-killing-of-mycobacterium-abscessus-by-intra-and-extracellular-mechanisms
#10
Kenneth C Malcolm, Silvia M Caceres, Kerstin Pohl, Katie R Poch, Audrey Bernut, Laurent Kremer, Donna L Bratton, Jean-Louis Herrmann, Jerry A Nick
Mycobacterium abscessus, a rapidly growing nontuberculous mycobacterium, are increasingly present in soft tissue infections and chronic lung diseases, including cystic fibrosis, and infections are characterized by growth in neutrophil-rich environments. M. abscessus is observed as two distinct smooth and rough morphotypes. The environmental smooth morphotype initiates infection and has a relatively limited ability to activate neutrophils. The rough morphotype has increased virulence and immunogenicity. However, the neutrophil response to the rough morphotype has not been explored...
2018: PloS One
https://www.readbyqxmd.com/read/29661870/amikacin-inhalation-as-salvage-therapy-for-refractory-nontuberculous-mycobacterial-lung-disease
#11
Byung Woo Jhun, Bumhee Yang, Seong Mi Moon, Hyun Lee, Hye Yun Park, Kyeongman Jeon, O Jung Kwon, Jungmin Ahn, Il Joon Moon, Sung Jae Shin, Charles L Daley, Won-Jung Koh
Although guidelines recommend amikacin (AMK) inhalation therapy for difficult-to-treat nontuberculous mycobacterial lung disease (NTM-LD), data are limited regarding the safety and clinical efficacy of this salvage therapy. We retrospectively evaluated treatment outcomes of 77 patients with refractory NTM-LD caused by Mycobacterium abscessus complex (MABC) or M. avium complex (MAC) who initiated AMK inhalation therapy between February 2015 and June 2016. MABC was the most common etiology (n = 48, 62%), followed by MAC (n = 20, 26%) and mixed infections (n = 9, 12%)...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29649431/diagnosis-and-management-of-children-with-mycobacterium-abscessus-infections-in-the-head-and-neck
#12
Justine Moe, Roy Rajan, Shelley Caltharp, Shelly Abramowicz
PURPOSE: Controversy exists regarding the most appropriate treatment strategy for children with nontuberculous mycobacterial (NTM) cervical lymphadenitis. Mycobacterium abscessus (MAB) is an uncommon cause of NTM cervical lymphadenitis. The purpose of the present study was to evaluate diagnosis, management, and treatment outcomes in children with MAB-associated cervical lymphadenitis resulting from a pulpotomy. MATERIALS AND METHODS: This was a retrospective chart review of children with NTM lymphadenitis of the head and neck caused by MAB treated at Children's Healthcare of Atlanta hospitals (Atlanta, GA)...
March 22, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29607168/the-outcomes-of-anatomical-lung-resection-for-nontuberculous-mycobacterial-lung-disease
#13
Tadashi Sakane, Katsunari Matsuoka, Sakiko Kumata, Risa Watanabe, Tetsu Yamada, Takahisa Matsuoka, Shinjiro Nagai, Mitsuhiro Ueda, Yoshihiro Miyamoto
Background: The number of cases of nontuberculous mycobacterial (NTM) lung disease has been increasing in recent years, and the efficacy of surgical treatment has been recognized. We investigated the clinical characteristics and behavior of NTM lung disease and analyzed the outcomes of surgery. Methods: The data of 25 patients who underwent anatomical resection for NTM lung disease in our institution between January 2004 and December 2014 were retrospectively examined...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29605219/bacterial-pneumonia-in-kidney-transplant-recipients
#14
REVIEW
D Wilmes, E Coche, H Rodriguez-Villalobos, N Kanaan
Bacterial pathogens are the most frequent cause of pneumonia after transplantation. Early after transplantation, recipients are at higher risk for nosocomial infections. The most commonly encountered pathogens during this period are gram-negative bacilli (Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa …), but gram-positive coccus such as Staphylococcus aureus or Streptococcus pneumoniae and anaerobic bacteria can also be found. Empirical antibiotic therapy should be guided by previous colonisation of the recipient and bacterial resistance pattern in the hospital...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29594145/exit-site-infection-due-to-mycobacterium-chelonae-in-an-elderly-patient-on-peritoneal-dialysis
#15
Arata Hibi, Takahisa Kasugai, Keisuke Kamiya, Chiharu Ito, Satoru Kominato, Toshiyuki Miura, Katsushi Koyama
Nontuberculous mycobacteria (NTM) are rarely isolated from peritoneal dialysis (PD)-associated catheter infections. However, NTM infection is usually difficult to treat and leads to catheter loss. Prompt diagnosis is essential for appropriate treatment. A 70-year-old Japanese man who had been on PD for 2 years and with a medical history of 2 episodes of exit site infections (ESIs) due to methicillin-resistant Staphylococcus aureus was admitted to the hospital due to suspected ESI recurrence. However, Gram staining of the pus revealed no gram-positive cocci...
January 2018: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29584893/increase-in-childhood-nontuberculous-mycobacterial-infections-after-bcg-coverage-drop-a-nationwide-population-based-retrospective-study-finland-1995-to-2016
#16
Antti Kontturi, Hanna Soini, Jukka Ollgren, Eeva Salo
Background: Epidemiological data on childhood nontuberculous mycobacterial (NTM) disease is scarce and the protective effect of Bacillus Calmette-Guérin (BCG) vaccination remains debated. In 2006 the BCG policy in Finland changed from universal to selective. We aimed to study the effect of the BCG coverage decrease on the incidence of childhood NTM infections in Finland. Methods: We conducted a nationwide, population-based, retrospective study of NTM notifications recorded to the National Infectious Diseases Register between 1995 and 2016 and identified native-born children aged 0-4 years infected with NTM...
March 23, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29582718/use-of-a-single-xpert-mtb-rif-assay-to-determine-the-duration-of-airborne-isolation-in-hospitalized-patients-with-suspected-pulmonary-tuberculosis
#17
Husain Poonawala, Surbhi Leekha, Sandra Medina-Moreno, Mala Filippell, J Kristie Johnson, Robert R Redfield, Kapil K Saharia
BACKGROUNDHospitalized patients with suspected tuberculosis (TB) are placed in airborne isolation until 3 sputum smear samples are negative for acid-fast bacilli (AFB). The Xpert MTB/RIF assay ("Xpert") nucleic acid amplification test (NAAT) to identify Mycobacterium tuberculosis DNA and resistance to rifampicin is superior to AFB sputum smear microscopy for the diagnosis of TB.OBJECTIVETo compare the performance of a single Xpert to AFB smear microscopy for time to airborne infection isolation (AII) discontinuation...
May 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29563388/prevalence-of-opportunistic-infections-and-causes-of-death-among-hospitalized-hiv-infected-patients-in-sichuan-china
#18
Wenwen Pang, Pengcheng Shang, Qingfeng Li, Jiao Xu, Lei Bi, Jing Zhong, Xiaofang Pei
Opportunistic infections (OIs) are the most significant complication of human immunodeficiency virus (HIV) infection. The prevalence of OIs differs among various countries in part due to different climates and socio-economic conditions. We, therefore, carried out the retrospective study at the Public Health Clinical Center of Chengdu, Sichuan to comprehensively investigate the prevalence of OIs, predictors of OIs, and risk factors for in-hospital death among HIV-infected patients. Sichuan in West China is characterized by the largest population living with HIV/Acquired immunodeficiency syndrome (AIDS) across China...
March 2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29556857/skin-and-soft-tissue-infections-due-to-nontuberculous-mycobacteria
#19
REVIEW
Elizabeth Ann Misch, Christopher Saddler, James Muse Davis
PURPOSE OF REVIEW: This review describes recent trends in the epidemiology of nontuberculous mycobacteria (NTM), emerging pathogens, new insights into NTM pathogenesis, and advances in diagnosis and treatment. RECENT FINDINGS: Emerging pathogens include Mycobacterium chimaera and drug-resistant subspecies of Mycobacterium abscessus. Important virulence mechanisms of pathogenic NTM include the ability to alter the macrophage's permissiveness to intracellular bacterial growth...
March 19, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29548037/marine-develops-chronic-right-knee-granuloma-after-initial-injury-at-the-basic-school
#20
Amarateedha H Prak, Kristina M Dela Rosa
With skin lesions that have failed previous treatments, consideration for an atypical mycobacteria, specifically Mycobacterium marinum, infection should be suspected. Importance of the history cannot be stressed as this is a clue that the patient may have been inoculated and infected in the field environment. A marine with chronic right knee plaque for 3 yr that first appeared after a field exercise at The Basic School but worsened despite treatment with clindamycin, TMP-SMX, and incision and drainage in 2012...
March 14, 2018: Military Medicine
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