Ali Kamran, Abdul Naman, Muhammad Irfan Majeed, Haq Nawaz, Najah Alwadie, Noor Ul Huda, Umm-E- Habiba, Tania Tabussam, Aqsa Bano, Hawa Hajab, Rabeea Razaq, Ayesha Ashraf, Saima Aziz, Maria Asghar, Muhammad Imran
The ability of surface-enhanced Raman spectroscopy (SERS) to generate spectroscopic fingerprints has made it an emerging tool for biomedical applications. The objective of this study is to confirm the potential use of Raman spectroscopy for early disease diagnosis based on blood serum. In this study, a total of sixty blood serum samples, consisting of forty from diseased patients and twenty (controls) from healthy individuals, was used. Because disease biomarkers, found in the lower molecular weight fraction, are suppressed by higher molecular weight proteins, 50 kDa Amicon ultrafiltration centrifugation devices were used to produce two fractions from whole blood serum consisting of a filtrate, which is a low molecular weight fraction, and a residue, which is a high molecular weight fraction...
March 6, 2024: RSC Advances