Weicong Ren, Zichun Ma, Qiang Li, Rongmei Liu, Liping Ma, Cong Yao, Yuanyuan Shang, Xuxia Zhang, Mengqiu Gao, Shanshan Li, Yu Pang
BACKGROUND: Latent tuberculosis (TB) infection can progress to active TB, which perpetuates community transmission that undermines global TB control efforts. Clinically, interferon-γ release assays (IGRAs) are commonly used for active TB case detection. However, low IGRA sensitivity rates lead to false-negative results for a high proportion of active TB cases, thus highlighting IGRA ineffectiveness in differentiating MTB-infected individuals from healthy individuals. METHODS: Participants enrolled at Beijing Chest Hospital from May 2020-April 2022 were assigned to healthy control (HC), LTBI, IGRA-positive TB, and IGRA-negative TB groups...
2024: Frontiers in Immunology