keyword
MENU ▼
Read by QxMD icon Read
search

Latent TB infection

keyword
https://www.readbyqxmd.com/read/29779770/normalised-quantitative-polymerase-chain-reaction-for-diagnosis-of-tuberculosis-associated-uveitis
#1
Manas Ranjan Barik, Soveeta Rath, Rohit Modi, Rajkishori Rana, Mamatha M Reddy, Soumyava Basu
Polymerase chain reaction (PCR)-based diagnosis of tuberculosis-associated uveitis (TBU) in TB-endemic countries is challenging due to likelihood of latent mycobacterial infection in both immune and non-immune cells. In this study, we investigated normalised quantitative PCR (nqPCR) in ocular fluids (aqueous/vitreous) for diagnosis of TBU in a TB-endemic population. Mycobacterial copy numbers (mpb64 gene) were normalised to host genome copy numbers (RNAse P RNA component H1 [RPPH1] gene) in TBU (n = 16) and control (n = 13) samples (discovery cohort)...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29778672/defective-myd88-and-irak4-but-not-tlr-2-expression-in-hiv-individuals-with-latent-tuberculosis-infection
#2
Kamakshi Prudhula Devalraju, Venkata Sanjeev Kumar Neela, Ramulu Gaddam, Arunabala Chaudhury, Abhinav Van, Siva Sai Krovvidi, Ramakrishna Vankayalapati, Vijaya Lakshmi Valluri
HIV infection markedly increases the likelihood of latent tuberculosis infection progressing to active TB. Information on expression of TLR-2, myeloid differentiation factor (MyD88), IL-1R- associated kinase-4 (IRAK4) and nuclear factor kappa B (NF-kB) in HIV+LTBI+ and HIV+ patients with active TB disease is limited. We found significantly higher percentages of CD14+TLR2+ cells in PBMCs of HIV+LTBI+ patients compared to HIV-LTBI+ individuals. γ-irradiated Mtb was unable to induce MyD88, IRAK4 expression and IL-1β, MCP-1, IP-10 production in HIV+LTBI+ patients...
May 17, 2018: Cytokine
https://www.readbyqxmd.com/read/29777718/malnutrition-is-associated-with-diminished-baseline-and-mycobacterial-antigen-stimulated-chemokine-responses-in-latent-tuberculosis-infection
#3
Rajamanickam Anuradha, Saravanan Munisankar, Yukthi Bhootra, Nathella Pavan Kumar, Chandrakumar Dolla, Subash Babu
OBJECTIVES: Previous studies have demonstrated a diminution in the baseline and mycobacterial antigen - specific cytokines in low body mass index (LBMI) individuals with latent tuberculosis infection (LTBI). We hypothesized that LBMI might be also associated with alteration in the baseline and antigen - stimulated levels of chemokines in LTBI. METHODS: To test this hypothesis, we examined baseline, TB- antigen and mitogen stimulated levels of chemokines in these individuals and compared them with those with LTBI and normal BMI (NBMI)...
May 16, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29773096/acceptance-of-chemo-prophylaxis-for-latent-tuberculosis-infection-among-high-school-college-student-contacts-of-tuberculosis-patients-in-shanghai-china
#4
Yang Li, Yi Hui Zheng, Li Ping Lu, Mei Xia Yang, Chang Ming Zhou, Zheng An Yuan, Yi Hu, Biao Xu
Student contacts of tuberculosis (TB) cases are susceptible to latent tuberculosis infection (LTBI), and chemo-prophylaxis can reduce the risk of active TB among them. This study aimed to assess the acceptance of chemo-prophylaxis for LTBI among students, and their concerns regarding TB and its preventive treatment. A total of 560 students contacts were included in the investigation. The extent of contact was categorized from high to low (4 levels) with 12.9% of the students being close contacts. About 87.0% of the students were willing to receive chemo-prophylaxis if diagnosed with, LTBI, whereas 73 students declined...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29767733/risk-and-timing-of-tuberculosis-among-close-contacts-of-persons-with-infectious-tuberculosis
#5
Mary R Reichler, Awal Khan, Timothy R Sterling, Hui Zhao, Joyce Moran, James McAuley, Patricia Bessler, Bonita Mangura
Background: The risk and timing of tuberculosis (TB) among recently exposed close contacts of patients with infectious TB is not well established. Methods: We prospectively enrolled culture-confirmed pulmonary TB patients ≥15 years of age and their close contacts at nine health departments in the United States and Canada. Close contacts were screened and cross-matched with TB registries to identify those who developed TB. Results: TB was diagnosed in 158 (4%) of 4490 contacts to 718 index TB patients...
May 15, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29764370/-tuberculosis-in-advanced-hiv-infection-is-associated-with-increased-expression-of-ifn%C3%AE-and-its-downstream-targets
#6
Sheetal Verma, Peicheng Du, Damalie Nakanjako, Sabine Hermans, Jessica Briggs, Lydia Nakiyingi, Jerrold J Ellner, Yukari C Manabe, Padmini Salgame
BACKGROUND: Tuberculosis (TB) is the major cause of death in Human Immunodeficiency Virus (HIV)-infected individuals. However, diagnosis of TB in HIV remains challenging particularly when HIV infection is advanced. Several gene signatures and serum protein biomarkers have been identified that distinguish active TB from latent infection. Our study was designed to assess if gene expression signatures and cytokine levels would distinguish active TB in advanced HIV. METHODS: We conducted a case-control study of whole blood RNA-Seq and plasma cytokine/chemokine analysis in HIV-infected with CD4+ T cell count of ≤ 100 cells/μl, with and without active TB...
May 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29762657/prospects-for-tuberculosis-elimination-in-the-united-states-results-of-a-transmission-dynamic-model
#7
Nicolas A Menzies, Ted Cohen, Andrew N Hill, Reza Yaesoubi, Kara Galer, Emory Wolf, Suzanne M Marks, Joshua A Salomon
We estimated long-term tuberculosis (TB) trends in the US population and assessed prospects for TB elimination. We used a detailed simulation model allowing for changes in TB transmission, immigration, and other TB risk determinants. We evaluated 5 hypothetical scenarios from 2017 to 2100: 1) maintain current TB prevention and treatment activities (base-case), 2) provision of latent TB infection testing and treatment for new legal immigrants, 3) increased uptake of latent TB infection screening and treatment among high-risk populations, including a 3-month isoniazid-rifapentine regimen, 4) improved TB case detection, 5) improved TB treatment quality...
May 14, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29761628/recent-advances-for-identification-of-new-scaffolds-and-drug-targets-for-mycobacterium-tuberculosis
#8
REVIEW
Rohan Dhiman, Ramandeep Singh
Tuberculosis (TB) is a leading cause of mortality and morbidity with an estimated 1.7 billion people latently infected with the pathogen worldwide. Clinically, TB infection presents itself as an asymptomatic infection, which gradually manifests to life threatening disease. The emergence of various drug resistant strains of Mycobacterium tuberculosis and lengthy duration of chemotherapy are major challenges in the field of TB drug development. Hence, there is an urgent need to develop scaffolds that possess a novel mechanism of action, can shorten the duration of therapy, and are active against both drug resistant and susceptible strains...
May 14, 2018: IUBMB Life
https://www.readbyqxmd.com/read/29757355/a-prospective-study-to-monitor-for-tuberculosis-during-anti-tumour-necrosis-factor-therapy-in-patients-with-inflammatory-bowel-disease-and-immune-mediated-inflammatory-diseases
#9
Choon Kin Lee, Sunny H Wong, Grace Lui, Whitney Tang, Lai San Tam, Margaret Ip, Esther Hung, Minhu Chen, Justin C Wu, Siew C Ng
Background: Biologic therapies have revolutionised the treatment of immune- mediated diseases including inflammatory bowel disease (IBD) and rheumatological disorders. However, biologic treatments are associated with an increased risk of reactivation of latent tuberculosis. Data of regular monitoring for latent tuberculosis infection (LTBI) during biologic treatment are lacking. Methods: Consecutive patients eligible for biologic therapies were screened for LTBI and prospectively followed-up for 3 years...
May 11, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29755013/screening-for-latent-tuberculosis-infection-in-patients-with-inflammatory-bowel-disease-can-interferon-gamma-release-assays-replace-the-tuberculin-skin-test
#10
José Luis Cabriada, Rafael Ruiz-Zorrilla, Jesús Barrio, Ramón Atienza, Alain Huerta, Iago Rodríguez-Lago, Antonio Bernal, César Herrero
BACKGROUND/AIMS: Screening for latent tuberculosis infection is mandatory before starting anti-tumor necrosis factor therapy. New assays based on interferon-γ (IFN-γ) release have recently become available and may be more accurate. The aim of this study was to compare QuantiFERON-TB and tuberculin skin test in screening for latent infection in patients with inflammatory bowel disease. MATERIALS AND METHODS: We prospectively screened 138 patients with inflammatory bowel disease for latent tuberculosis infection with chest X-ray, tuberculin skin test, and a third-generation QuantiFERON-TB test...
May 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29752996/unmasking-leading-to-a-health-care-worker-mycobacterium-tuberculosis-transmission
#11
Kerry L Holden, Craig W Bradley, Evonne T Curran, Christopher Pollard, Grace Smith, Elisabeth Holden, Patricia Glynn, Mark Garvey
BACKGROUND: Mycobacterium tuberculosis is a major health burden worldwide. The disease can present as an individual case, community outbreak or more rarely a nosocomial outbreak. Even in countries with a low prevalence such as the UK, tuberculosis (TB) presents a risk to healthcare workers (HCWs). AIM: To report an outbreak which manifested 12 months after a patient with pulmonary tuberculosis was admitted to Queen Elizabeth Hospital Birmingham (QEHB). METHODS: We present the epidemiological and outbreak investigations; the role of whole genome sequencing (WGS) in identifying the outbreak and control measures to prevent further outbreaks...
May 9, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29751780/quantiferon-tb-gold-in-tube-test-for-the-diagnosis-of-active-and-latent-tuberculosis-in-selected-health-facilities-of-addis-ababa-ethiopia
#12
Selam Niguse, Kassu Desta, Gebremdihin Gebremichael, Atsebeha Gebrezgeaxier, Mulluwork Getahun, Desta Kassa
OBJECTIVE: To determine the performance of QuantiFERON-TB IN-Gold for the diagnosis active tuberculosis and latent tuberculosis. RESULTS: A total of 213 participants (136 tuberculosis suspects, 66 latently infected) were enrolled. Of 213, 21 (15.4%) of the tuberculosis suspects and 3 (4.5%) of the latent tuberculosis groups were human immunodeficiency virus infected. The sensitivity, specificity, positive and negative predictive value of QuantiFERON-TB IN-Gold for the diagnosis of active tuberculosis was 70...
May 11, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29750144/towards-the-elimination-of-paediatric-tuberculosis-in-high-income-immigrant-receiving-countries-a-25-year-conventional-and-molecular-epidemiological-case-study
#13
Vivek Dhawan, Jennifer Bown, Angela Lau, Deanne Langlois-Klassen, Dennis Kunimoto, Ravi Bhargava, Linda Chui, Simon M Collin, Richard Long
The epidemiology of tuberculosis (TB) in high-income countries is increasingly dictated by immigration. The influence of this trend on paediatric TB and TB elimination are not well defined. We undertook a 25-year conventional and molecular epidemiologic study of paediatric TB in Alberta, one of four major immigrant-receiving provinces in Canada. All isolates of Mycobacterium tuberculosis were DNA fingerprinted using standard methodology. Between 1990 and 2014, 176 children aged 0-14 years were diagnosed with TB...
April 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29749875/missed-opportunities-for-tuberculosis-prevention-among-patients-accessing-a-uk-hiv-service
#14
Hannah M Rickman, Robert F Miller, Stephen Morris-Jones, Lusha Kellgren, Simon G Edwards, Alison D Grant
United Kingdom guidelines recommend screening for and treatment of latent tuberculosis infection (LTBI) in HIV-positive patients at high risk of active tuberculosis (TB) disease, but implementation is suboptimal. We investigated potential missed opportunities to identify and treat LTBI among HIV-positive patients accessing a large HIV outpatient service in London. Case records of all adult patients attending our service for HIV care diagnosed with active TB between 2011 and 2015 were reviewed to determine whether they met criteria for LTBI screening and whether screening was undertaken...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29746954/combined-ifn-%C3%AE-and-tnf-%C3%AE-release-assay-for-differentiating-active-tuberculosis-from-latent-tuberculosis-infection
#15
Ji Yeun Kim, Joung Ha Park, Min Chul Kim, Hye Hee Cha, Na-Young Jeon, Seong Yeon Park, Min-Jae Kim, Yong-Phil Chong, Sang Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung Han Kim
OBJECTIVES: The IFN-γ-release assay (IGRA) cannot differentiate active tuberculosis (TB) from latent TB infection (LTBI). We hypothesized that the TNF-α-release assay (TARA) combined with IGRA might discriminate active TB from not active TB without LTBI. METHODS: Adult patients with suspected TB, and with unrelated diseases such as herpes zoster as controls, were enrolled in an intermediate TB-burden country. Patients with confirmed or probable TB were regarded as active TB, and patients with not active TB were further classified as those having not active TB with and without LTBI based on IGRA results...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746953/reversion-of-quantiferon-tb-gold-in-tube-test-in-individuals-with-and-without-prophylactic-treatment-for-latent-tuberculosis-infection-a-systematic-review-and-meta-analysis
#16
Haoran Zhang, Henan Xin, Xiangwei Li, Hengjing Li, Mufei Li, Boxuan Feng, Lei Gao
OBJECTIVES: Reversion of tuberculosis (TB) infection testing has been suggested to be associated with prophylactic treatment efficacy. However, evidences based on randomized controlled study were sparse. METHODS: Studies on serial QuantiFERON-TB Gold In-Tube (QFT) test, among individuals with and without prophylactic treatment were identified in the databases of PubMed, MEDLINE and EMBASE up to 28 February 2018. The reversion rates were quantitatively summarized by means of meta-analysis using the random-effect model...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29743310/comparison-of-the-quantiferon-tb-gold-plus-and-quantiferon-tb-gold-in-tube-interferon-%C3%AE-release-assays-in-patients-at-risk-for-tuberculosis-and-in-healthcare-workers
#17
Elitza S Theel, Heather Hilgart, Margaret Breen-Lyles, Kevin McCoy, Rhiannon Flury, Laura E Breeher, John Wilson, Irene G Sia, Jennifer A Whitaker, Jeremy Clain, Timothy R Aksamit, Patricio Escalante
The QuantiFERON-TB Gold Plus (QFT-Plus; Qiagen, Germantown, MD) interferon-gamma release assay (IGRA) received FDA-clearance in 2017 and will replace the prior version of the assay, the QFT-Gold In Tube (QFT-GIT). Here, we compared performance of the QFT-Plus assay to the QFT-GIT version in a diverse patient population, including patients undergoing evaluation for or follow-up of latent tuberculosis infection (LTBI; n=39) or active TB (n=3), and in healthcare workers (HCWs; n=119) at Mayo Clinic (Rochester, MN)...
May 9, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29731933/latent-tuberculosis-infection-diagnosis-and-treatment
#18
Biljana Ilievska-Poposka, Marija Metodieva, Maja Zakoska, Cveta Vragoterova, Dejan Trajkov
INTRODUCTION: Latent tuberculosis infection (LTBI) is defined as a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens without evidence of clinically manifested active tuberculosis (TB). Diagnosis and treatment for LTBI are important for TB, especially in high-risk populations. Tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used to diagnose LTBI. AIM: The study aims to present the first results with IGRA test compared with TST in the screening of LTBI and the treatment results in the cases with LTBI in Macedonia...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29728811/guards-in-prisons-a-risk-group-for-latent-tuberculosis-infection
#19
Luisa Arroyave, Yoav Keynan, Deny Sanchez, Lucelly López, Diana Marin, Maryluz Posada, Zulma Vanessa Rueda
To determine the prevalence and incidence of LTBI among prison guards and to the risk factors associated with infection. Two male prisons in Medellín and Itaguí, Colombia. A cohort study was conducted in adult prison guards that consented to participate. Exclusion criteria included: previous or current active TB, or conditions that preclude TST administration. We screened 194 guards and completed 155 TST administrations. The prevalence of LTBI was 55.8% in prison one, and 39.1% in prison two. The risk factors associated with LTBI diagnosis included drug use at least once in a lifetime (PR: 1...
May 4, 2018: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29720072/the-epidemiology-of-tuberculosis-in-the-australia-capital-territory-2006-2015
#20
Belinda J Jones, Vanessa Johnston, Ranil D Appuhamy, Marlena Kaczmarek, Mark Hurwitz
Aim: To review the epidemiology of tuberculosis (TB) in the Australian Capital Territory (ACT) over a 10 year period. Methods: A retrospective analysis of the ACT TB notification data from 1 January 2006 to 31 December 2015 was conducted. Results: Over the 10 year study period there were 171 TB notifications in the ACT, with an increasing trend in the number of notifications over time. The median age of cases was 36 years (range 14 to 91 years) and 53.8% of cases were male...
September 1, 2017: Communicable Diseases Intelligence Quarterly Report
keyword
keyword
39252
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"