keyword
https://read.qxmd.com/read/38506767/effects-of-transcranial-direct-current-stimulation-on-clinical-outcomes-calcitonin-gene-related-peptide-and-pituitary-adenylate-cyclase-activating-polypeptide-38-levels-in-menstrual-migraine
#1
JOURNAL ARTICLE
Buse Rahime Hasırcı Bayır, Serkan Aksu, Haşim Gezegen, Zerrin Karaaslan, Hande Yüceer, Tuba Cerrahoğlu Şirin, Cem İsmail Küçükali, Adnan Kurt, Sacit Karamürsel, Vuslat Yılmaz, Betül Baykan
OBJECTIVES: Transcranial direct current stimulation (tDCS) has been suggested as an alternative treatment option for migraine. The present study aimed to evaluate the efficacy of tDCS on clinical outcomes in addition to calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating peptide 38 (PACAP-38) levels in individuals with menstrual-related migraine (MRM) for the first time. MATERIALS AND METHODS: In this parallel study, 58 female patients between the ages of 18 and 45 years, including 36 with MRM and 22 with nonmenstrual migraines (nMM), were recruited...
March 19, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38499216/pacap-sequence-modifications-modulate-the-peptide-antimicrobial-activity-against-bacterial-pathogens-affecting-aquaculture
#2
JOURNAL ARTICLE
Laura Rivera Méndez, Tania Rodríguez-Cornejo, Tania Rodríguez-Ramos, Lowia Al-Hussinee, Janet Velázquez, James Hugh Campbell, Yamila Carpio, Mario Pablo Estrada, Brian Dixon
The global aquaculture industry has significant losses each year due to disease outbreaks. Antibiotics are one of the common methods to treat fish infections, but prolonged use can lead to the emergence of resistant strains. Aeromonas spp. Infections are a common and problematic disease in fish, and members of this genera can produce antibiotic resistant strains. Antimicrobial peptides (AMPs) have emerged as an alternative method to treat and prevent infections and pituitary adenylate cyclase activating polypeptide (PACAP) is a prominent member of this family...
March 16, 2024: Fish & Shellfish Immunology
https://read.qxmd.com/read/38493178/rapid-evolution-of-an-adaptive-multicellular-morphology-of-candida-auris-during-systemic-infection
#3
JOURNAL ARTICLE
Jian Bing, Zhangyue Guan, Tianhong Zheng, Craig L Ennis, Clarissa J Nobile, Changbin Chen, Haiqing Chu, Guanghua Huang
Candida auris has become a serious threat to public health. The mechanisms of how this fungal pathogen adapts to the mammalian host are poorly understood. Here we report the rapid evolution of an adaptive C. auris multicellular aggregative morphology in the murine host during systemic infection. C. auris aggregative cells accumulate in the brain and exhibit obvious advantages over the single-celled yeast-form cells during systemic infection. Genetic mutations, specifically de novo point mutations in genes associated with cell division or budding processes, underlie the rapid evolution of this aggregative phenotype...
March 16, 2024: Nature Communications
https://read.qxmd.com/read/38398694/investigation-of-pacap38-and-pac1-receptor-expression-in-human-retinoblastoma-and-the-effect-of-pacap38-administration-on-human-y-79-retinoblastoma-cells
#4
JOURNAL ARTICLE
Dénes Tóth, Eszter Fábián, Edina Szabó, Evelin Patkó, Viktória Vicena, Alexandra Váczy, Tamás Atlasz, Tamás Tornóczky, Dóra Reglődi
Retinoblastoma represents the most prevalent malignant neoplasm affecting the eyes in childhood. The clear-cut origin of retinoblastoma has not yet been determined; however, based on experiments, it has been suggested that RB1 loss in cone photoreceptors causes retinoblastoma. Pituitary adenylate-cyclase activating polypeptide (PACAP) is a pleiotropic neuropeptide which has been shown to be affected in certain tumorous transformations, such as breast, lung, kidney, pancreatic, colon, and endocrine cancers. This study aimed to investigate potential changes in both PACAP38 and PAC1 receptor (PAC1R) expression in human retinoblastoma and the effect of PACAP38 administration on the survival of a human retinoblastoma cell line (Y-79)...
January 26, 2024: Life
https://read.qxmd.com/read/38397400/understanding-the-biological-relationship-between-migraine-and-depression
#5
REVIEW
Adrián Viudez-Martínez, Abraham B Torregrosa, Francisco Navarrete, María Salud García-Gutiérrez
Migraine is a highly prevalent neurological disorder. Among the risk factors identified, psychiatric comorbidities, such as depression, seem to play an important role in its onset and clinical course. Patients with migraine are 2.5 times more likely to develop a depressive disorder; this risk becomes even higher in patients suffering from chronic migraine or migraine with aura. This relationship is bidirectional, since depression also predicts an earlier/worse onset of migraine, increasing the risk of migraine chronicity and, consequently, requiring a higher healthcare expenditure compared to migraine alone...
January 30, 2024: Biomolecules
https://read.qxmd.com/read/38337150/targeting-the-pacap-38-pathway-is-an-emerging-therapeutic-strategy-for-migraine-prevention
#6
REVIEW
Lanfranco Pellesi, Messoud Ashina, Paolo Martelletti
INTRODUCTION: The pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) has emerged as a key mediator of migraine pathogenesis. PACAP-38 and its receptors are predominantly distributed in arteries, sensory and parasympathetic neurons of the trigeminovascular system. Phase 2 trials have tested human monoclonal antibodies designed to bind and inhibit PACAP-38 and the pituitary adenylate cyclase-activating polypeptide type I (PAC1 ) receptor for migraine prevention. AREAS COVERED: This review focuses on the significance of the PACAP-38 pathway as a target in migraine prevention...
February 9, 2024: Expert Opinion on Emerging Drugs
https://read.qxmd.com/read/38307672/emerging-and-future-directions-of-migraine-research-and-treatment
#7
REVIEW
Chia-Chun Chiang, David W Dodick
Despite many migraine-specific treatments that became available over the past 5 years, many patients still suffer from debilitating migraine. Emerging and future directions of migraine research and treatment should consider different aspects including revising the headache diagnostic criteria to reflect disease burden and prognosis, developing biomarkers, including genetic, serum, imaging, and deep phenotyping biomarkers to facilitate personalized medicine for headache treatment. Additionally, research should also emphasize identifying novel treatment targets for drug development...
2024: Handbook of Clinical Neurology
https://read.qxmd.com/read/38260572/a-pacap-activated-network-for-secretion-requires-coordination-of-ca-2-influx-and-ca-2-mobilization
#8
Xiaohuan Chen, Nicole A Bell, Breanna L Coffman, Agustin A Rabino, Rafael Garcia-Mata, Paul J Kammermeier, David I Yule, Daniel Axelrod, Alan V Smrcka, David R Giovannucci, Arun Anantharam
Chromaffin cells of the adrenal medulla transduce sympathetic nerve activity into stress hormone secretion. The two neurotransmitters principally responsible for coupling cell stimulation to secretion are acetylcholine and pituitary adenylate activating polypeptide (PACAP). In contrast to acetylcholine, PACAP evokes a persistent secretory response from chromaffin cells. However, the mechanisms by which PACAP acts are poorly understood. Here, it is shown that PACAP induces sustained increases in cytosolic Ca 2+ which are disrupted when Ca 2+ influx through L-type channels is blocked or internal Ca 2+ stores are depleted...
January 3, 2024: bioRxiv
https://read.qxmd.com/read/38244819/immunostimulant-effects-of-pituitary-adenylate-cyclase-activating-polypeptide-and-double-stranded-ds-rna-in-orconectes-propinquus
#9
JOURNAL ARTICLE
Emma C Monod, Jesús Luis Betancourt, Kayla A Samms, Tamiru N Alkie, Charlotte G Walmsley, Tania Rodríguez-Ramos, Stephanie J DeWitte-Orr, Brian Dixon
Disease outbreaks in crustacean aquaculture caused by opportunistic and obligate pathogens cause severe economic losses to the industry. Antibiotics are frequently used as prophylactic treatments worldwide, although its overuse and misuse has led to microbial resistance, which has driven the search for novel molecules with immunostimulant and antibacterial activities. Antimicrobial peptides (AMP) and double-stranded (ds)RNAs constitute promising immunostimulants in the fight against infectious diseases in aquaculture...
January 18, 2024: Fish & Shellfish Immunology
https://read.qxmd.com/read/38177337/a-pontomesencephalic-pacapergic-pathway-underlying-panic-like-behavioral-and-somatic-symptoms-in-mice
#10
JOURNAL ARTICLE
Sukjae J Kang, Jong-Hyun Kim, Dong-Il Kim, Benjamin Z Roberts, Sung Han
Panic disorder is characterized by uncontrollable fear accompanied by somatic symptoms that distinguish it from other anxiety disorders. Neural mechanisms underlying these unique symptoms are not completely understood. Here, we report that the pituitary adenylate cyclase-activating polypeptide (PACAP)-expressing neurons in the lateral parabrachial nucleus projecting to the dorsal raphe are crucial for panic-like behavioral and physiological alterations. These neurons are activated by panicogenic stimuli but inhibited in conditioned fear and anxiogenic conditions...
January 2024: Nature Neuroscience
https://read.qxmd.com/read/38169187/the-protective-effect-of-silver-nanoparticles-on-epithelial-cornea-cells-against-ultraviolet-is-accompanied-by-changes-in-calcium-homeostasis-and-a-decrease-of-the-p2x7-and-p2y2-receptors
#11
JOURNAL ARTICLE
Patryk Krzemiński, Irena Misiewicz-Krzemińska, Marta Grodzik, Irena Padzińska-Pruszyńska, Paulina Kucharzewska, Agnieszka Ostrowska, Ewa Sawosz, Paweł Pomorski
PURPOSE: The aim of the study was to evaluate the effect of silver nanoparticles hydrocolloids (AgNPs) on human corneal epithelial cells. Epithelial cells form the outermost and the most vulnerable to environmental stimuli layer of the cornea in the eye. Mechanical stress, UV radiation, and pathogens such as bacteria, viruses, and parasites challenge the fragile homeostasis of the eye. To help combat stress, infection, and inflammation wide portfolio of interventions is available. One of the oldest treatments is colloidal silver...
January 1, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38104724/developmental-adcyap1b-loss-leads-to-hemorrhage-disrupted-hemostasis-and-a-blood-coagulation-cascade-in-zebrafish
#12
JOURNAL ARTICLE
Xinyan Ma, Ruixian Guo, Huibo Xu, Yuanyuan Ma, Rui Zhang, Xinyan Liu, Jingpu Zhang, Ying Han
BACKGROUND: Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) is a neuropeptide with diverse roles in biological processes. Its involvement in the blood coagulation cascade is unclear. OBJECTIVES: This study unraveled adcyap1b's role in blood coagulation using CRISPR/Cas9 in zebrafish. Effects were validated via adcyap1b knockdown. Gene expression changes in adcyap1b mutants were explored, linking them to clotting disorders. An analysis of proca gene splicing illuminated its role in adcyap1b-related anticoagulation deficiencies...
December 15, 2023: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/38069018/impact-assessment-of-pituitary-adenylate-cyclase-activating-polypeptide-pacap-and-hemostatic-sponge-on-vascular-anastomosis-regeneration-in-rats
#13
JOURNAL ARTICLE
Laszlo Adam Fazekas, Balazs Szabo, Vince Szegeczki, Csaba Filler, Adam Varga, Zoltan Attila Godo, Gabor Toth, Dora Reglodi, Tamas Juhasz, Norbert Nemeth
The proper regeneration of vessel anastomoses in microvascular surgery is crucial for surgical safety. Pituitary adenylate cyclase-activating polypeptide (PACAP) can aid healing by decreasing inflammation, apoptosis and oxidative stress. In addition to hematological and hemorheological tests, we examined the biomechanical and histological features of vascular anastomoses with or without PACAP addition and/or using a hemostatic sponge (HS). End-to-end anastomoses were established on the right femoral arteries of rats...
November 24, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38068975/distribution-and-chemistry-of-phoenixin-14-a-newly-discovered-sensory-transmission-molecule-in-porcine-afferent-neurons
#14
JOURNAL ARTICLE
Urszula Mazur, Ewa Lepiarczyk, Paweł Janikiewicz, Elżbieta Łopieńska-Biernat, Mariusz Krzysztof Majewski, Agnieszka Bossowska
Phoenixin-14 (PNX), initially discovered in the rat hypothalamus, was also detected in dorsal root ganglion (DRG) cells, where its involvement in the regulation of pain and/or itch sensation was suggested. However, there is a lack of data not only on its distribution in DRGs along individual segments of the spinal cord, but also on the pattern(s) of its co-occurrence with other sensory neurotransmitters. To fill the above-mentioned gap and expand our knowledge about the occurrence of PNX in mammalian species other than rodents, this study examined (i) the pattern(s) of PNX occurrence in DRG neurons of subsequent neuromeres along the porcine spinal cord, (ii) their intraganglionic distribution and (iii) the pattern(s) of PNX co-occurrence with other biologically active agents...
November 23, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38063700/recent-uses-of-lipid-nanoparticles-cell-penetrating-and-bioactive-peptides-for-the-development-of-brain-targeted-nanomedicines-against-neurodegenerative-disorders
#15
REVIEW
Yu Wu, Angelina Angelova
The lack of effective treatments for neurodegenerative diseases (NDs) is an important current concern. Lipid nanoparticles can deliver innovative combinations of active molecules to target the various mechanisms of neurodegeneration. A significant challenge in delivering drugs to the brain for ND treatment is associated with the blood-brain barrier, which limits the effectiveness of conventional drug administration. Current strategies utilizing lipid nanoparticles and cell-penetrating peptides, characterized by various uptake mechanisms, have the potential to extend the residence time and bioavailability of encapsulated drugs...
November 23, 2023: Nanomaterials
https://read.qxmd.com/read/38056947/dynamic-sex-and-diet-specific-pleiotropism-in-the-pac1-receptor-mediated-regulation-of-arcuate-proopiomelanocortin-and-neuropeptide-y-agouti-related-peptide-neuronal-excitability-by-anorexigenic-ventromedial-nucleus-pacap-neurons
#16
JOURNAL ARTICLE
Veronica Mata-Pacheco, Jennifer Hernandez, Nandini Varma, Jenny Xu, Sarah Sayers, Nikki Le, Edward J Wagner
This study furthers the investigation of how pituitary adenylate cyclase activating polypeptide (PACAP) and the PAC1 receptor (PAC1R) regulate the homeostatic energy balance circuitry. We hypothesized that apoptotic ablation of PACAP neurones in the hypothalamic ventromedial nucleus (VMN) would affect both energy intake and energy expenditure. We also hypothesized that selective PAC1R knockdown would impair the PACAP-induced excitation in anorexigenic proopiomelanocortin (POMC) neurones and inhibition of orexigenic neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurones in the hypothalamic arcuate nucleus (ARC)...
December 6, 2023: Journal of Neuroendocrinology
https://read.qxmd.com/read/38053471/pituitary-adenylate-cyclase-activating-polypeptide-pacap-of-the-bed-nucleus-of-the-stria-terminalis-mediates-heavy-alcohol-drinking-in-mice
#17
JOURNAL ARTICLE
Lauren Lepeak, Sophia Miracle, Antonio Ferragud, Mariel P Seiglie, Samih Shafique, Zeynep Ozturk, Margaret A Minnig, Gianna Medeiros, Pietro Cottone, Valentina Sabino
Alcohol use disorder (AUD) is a complex psychiatric disease characterized by periods of heavy drinking and periods of withdrawal. Chronic exposure to ethanol causes profound neuroadaptations in the extended amygdala, which cause allostatic changes promoting excessive drinking. The bed nucleus of the stria terminalis (BNST), a brain region involved in both excessive drinking and anxiety-like behavior, shows particularly high levels of pituitary adenylate cyclase activating polypeptide (PACAP), a key mediator of the stress response...
November 29, 2023: ENeuro
https://read.qxmd.com/read/38025265/increased-pituitary-adenylate-cyclase-activating-peptide-genes-expression-in-the-prefrontal-cortex-in-schizophrenia-in-relation-to-suicide
#18
JOURNAL ARTICLE
Zala Slabe, Rawien A Balesar, Ronald W H Verwer, Gorazd Drevenšek, Dick F Swaab
INTRODUCTION: Pituitary adenylate cyclase-activating peptide (PACAP) is a stress-related neuropeptide that is produced in several brain areas. It acts by 3 receptors: PACAP type-1 (PAC1), vasoactive intestinal peptide (VIP) -1 and -2 (VPAC1 and 2). Data on polymorphisms in PACAP and PAC1 indicate a relationship of the PACAP system with schizophrenia (SCZ). METHODS: The prefrontal cortex was chosen to measure PACAP-gene related expression changes, since this is a central structure in the symptoms of schizophrenia (SCZ)...
2023: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/37998384/from-cgrp-to-pacap-vip-and-beyond-unraveling-the-next-chapters-in-migraine-treatment
#19
REVIEW
Masaru Tanaka, Ágnes Szabó, Tamás Körtési, Délia Szok, János Tajti, László Vécsei
Migraine is a neurovascular disorder that can be debilitating for individuals and society. Current research focuses on finding effective analgesics and management strategies for migraines by targeting specific receptors and neuropeptides. Nonetheless, newly approved calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) have a 50% responder rate ranging from 27 to 71.0%, whereas CGRP receptor inhibitors have a 50% responder rate ranging from 56 to 71%. To address the need for novel therapeutic targets, researchers are exploring the potential of another secretin family peptide, pituitary adenylate cyclase-activating polypeptide (PACAP), as a ground-breaking treatment avenue for migraine...
November 17, 2023: Cells
https://read.qxmd.com/read/37998368/potential-crosstalk-between-the-pacap-vip-neuropeptide-system-and-endoplasmic-reticulum-stress-relevance-to-multiple-sclerosis-pathophysiology
#20
REVIEW
Minduli Withana, Alessandro Castorina
Multiple sclerosis (MS) is an immune-mediated disorder characterized by focal demyelination and chronic inflammation of the central nervous system (CNS). Although the exact etiology is unclear, mounting evidence indicates that endoplasmic reticulum (ER) stress represents a key event in disease pathogenesis. Pituitary adenylate cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP) are two structurally related neuropeptides that are abundant in the CNS and are known to exert neuroprotective and immune modulatory roles...
November 15, 2023: Cells
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