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https://www.readbyqxmd.com/read/27888461/inhibitory-effects-of-bee-venom-and-its-components-against-viruses-in-vitro-and-in-vivo
#1
Md Bashir Uddin, Byeong-Hoon Lee, Chamilani Nikapitiya, Jae-Hoon Kim, Tae-Hwan Kim, Hyun-Cheol Lee, Choul Goo Kim, Jong-Soo Lee, Chul-Joong Kim
Bee venom (BV) from honey bee (Apis Melifera L.) contains at least 18 pharmacologically active components including melittin (MLT), phospholipase A2 (PLA2), and apamin etc. BV is safe for human treatments dose dependently and proven to possess different healing properties including antibacterial and antiparasitidal properties. Nevertheless, antiviral properties of BV have not well investigated. Hence, we identified the potential antiviral properties of BV and its component against a broad panel of viruses. Co-incubation of non-cytotoxic amounts of BV and MLT, the main component of BV, significantly inhibited the replication of enveloped viruses such as Influenza A virus (PR8), Vesicular Stomatitis Virus (VSV), Respiratory Syncytial Virus (RSV), and Herpes Simplex Virus (HSV)...
December 2016: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/27883971/2-3-7-8-tetrachlorodibenzo-p-dioxin-and-the-viral-infection
#2
REVIEW
Filomena Fiorito, Rita Santamaria, Carlo Irace, Luisa De Martino, Giuseppe Iovane
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a widespread highly toxic environmental contaminant, suppresses immune response and leads to an increased susceptibility to infectious agents. In particular, several studies have provided evidence that TCDD decreases resistance to numerous viruses. Indeed, in vivo and in vitro investigations showed that the presence of TCDD is able to interfere with the replication of both human and animal viruses, such as influenza A viruses, coxsackie virus B3, immunodeficiency virus type-1 (HIV-1), cytomegalovirus (CMV), herpes simplex II, and bovine herpesvirus 1...
November 21, 2016: Environmental Research
https://www.readbyqxmd.com/read/27859744/hand-foot-and-mouth-disease-an-overview-of-clinical-features-in-adult-patients
#3
I Neri, M A Chessa, A Virdi, A Patrizi
Hand, foot and mouth disease (HFMD) mainly affects children aged <5 years and is caused by several serotypes of enteroviruses, more frequently Enterovirus 71 (EV71) and Coxsackie A16 (CA16)(1) . The disease presents with vesicles in the mouth, hands, feet and buttocks. Only 1% of infected adults develop clinical manifestations, probably as a result of immunological memory(1). Nevertheless, in the atypical HFMD caused by Coxsackie virus A6 (CVA6) the involvement of immunocompetent adults has been recently described(2-6) ...
November 11, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27845890/virus-inactivation-under-the-photodynamic-effect-of-phthalocyanine-zinc-ii-complexes
#4
Mimi Remichkova, Luchia Mukova, Lubomira Nikolaeva-Glomb, Nadya Nikolova, Lubka Doumanova, Vanya Mantareva, Ivan Angelov, Veselin Kussovski, Angel S Galabov
Various metal phthalocyanines have been studied for their capacity for photodynamic effects on viruses. Two newly synthesized water-soluble phthalocyanine Zn(II) complexes with different charges, cationic methylpyridyloxy-substituted Zn(II)- phthalocyanine (ZnPcMe) and anionic sulfophenoxy-substituted Zn(II)-phthalocyanine (ZnPcS), were used for photoinactivation of two DNA-containing enveloped viruses (herpes simplex virus type 1 and vaccinia virus), two RNA-containing enveloped viruses (bovine viral diarrhea virus and Newcastle disease virus) and two nude viruses (the enterovirus Coxsackie B1, a RNA-containing virus, and human adenovirus 5, a DNA virus)...
November 15, 2016: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/27819276/children-s-caregivers-and-public-playgrounds-potential-reservoirs-of-infection-of-hand-foot-and-mouth-disease
#5
Pengyuan Li, Tao Li, Qiuyun Gu, Xiaomin Chen, Jiahui Li, Xiashi Chen, Yan Chen, Danwei Zhang, Rong Gao, Zhenjian He, Xun Zhu, Wangjian Zhang, Yuantao Hao, Dingmei Zhang
Hand-foot-and-mouth disease (HFMD) is a common infectious disease, which has led to millions of clinical cases and hundreds of deaths every year in China. This study aimed to exploring the effects on HFMD transmission of children's caregivers and public area, as well as trying to locate the potential reservoirs of infections in primary cases. Total children's 257 samples (98 children's caregivers and 159 environmental samples) were tested for the presence of universal enterovirus, enterovirus 71, coxsackie virus A6 and A16 by real-time fluorescence quantitative polymerase chain reaction (qPCR)...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27792321/antiviral-triterpenes-from-the-twigs-and-leaves-of-lyonia-ovalifolia
#6
Xiao-Jing Lv, Yong Li, Shuang-Gang Ma, Jing Qu, Yun-Bao Liu, Yu-Huan Li, Dan Zhang, Li Li, Shi-Shan Yu
Eleven new 9,10-seco-cycloartan triterpene glycosides (1-11), seven new lanostane triterpene glycosides (12-18), and two new ursane triterpenoids (19-20) were isolated from the twigs and leaves of Lyonia ovalifolia. The structures of these compounds were elucidated by extensive MS and NMR spectroscopic analysis. The absolute configuration of compound 1a (the aglycone of 1) was established by X-ray crystallography, and that of C-24 in compounds 2, 7, and 12 was established by Mo2(OAc)4-induced electronic circular dichroism experiments...
October 28, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/27773751/soluble-coxsackie-and-adenovirus-receptor-scar-fc-a-highly-efficient-compound-against-laboratory-and-clinical-strains-of-coxsackie-b-virus
#7
Sandra Pinkert, Babette Dieringer, Sabine Diedrich, Heinz Zeichhardt, Jens Kurreck, Henry Fechner
Coxsackie-B-viruses (CVB) cause a wide variety of diseases, ranging from mild syndromes to life-threatening conditions such as pancreatitis, myocarditis, meningitis and encephalitis. Especially newborns and young infants develop severe diseases and long-term sequelae may occur among survivors. Due to lack of specific antiviral therapy the current treatment of CVB infection is limited to symptomatic treatment. Here we analyzed the antiviral activity of a soluble receptor fusion protein, containing the extracellular part of the coxsackievirus and adenovirus receptor (CAR) fused to the constant domain of the human IgG - sCAR-Fc - against laboratory and clinical CVB strains...
October 20, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27767087/adenovirus-coxsackie-adenovirus-receptor-mediated-binding-to-human-erythrocytes-does-not-preclude-systemic-transduction
#8
L A Rojas, R Moreno, H Calderón, R Alemany
There is great skepticism in the capability of adenovirus vectors and oncolytic adenoviruses to reach specific organs or tumors upon systemic administration. Besides antibodies, the presence of CAR (coxsackie and adenovirus receptor) in human erythrocytes has been postulated to sequester CAR-binding adenoviruses, commonly used in gene therapy and oncolytic applications. The use of non-CAR-binding fibers or serotypes has been postulated to solve this limitation. Given the lack of integrins in erythrocytes and therefore of internalization of the CAR-bound virus, we hypothesized that the interaction of adenovirus type 5 (Ad5) with CAR in human erythrocytes could be reversible...
October 21, 2016: Cancer Gene Therapy
https://www.readbyqxmd.com/read/27766098/il-9-inhibits-viral-replication-in-coxsackievirus-b3-induced-myocarditis
#9
Miao Yu, Qi Long, Huan-Huan Li, Wei Liang, Yu-Hua Liao, Jing Yuan, Xiang Cheng
Myocardial injuries in viral myocarditis (VMC) are caused by viral infection and related autoimmune disorders. Recent studies suggest that IL-9 mediated both antimicrobial immune and autoimmune responses in addition to allergic diseases. However, the role of IL-9 in viral infection and VMC remains controversial and uncertain. In this study, we infected Balb/c mice with Coxsackievirus B3 (CVB3), and found that IL-9 was enriched in the blood and hearts of VMC mice on days 5 and 7 after virus infection. Most of IL-9 was secreted by CD8(+) T cells on day 5 and CD4(+) T cells on day 7 in the myocardium...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27752104/large-outbreak-of-herpangina-in-children-caused-by-enterovirus-in-summer-of-2015-in-hangzhou-china
#10
Wei Li, Hui-Hui Gao, Qiong Zhang, Yu-Jie Liu, Ran Tao, Yu-Ping Cheng, Qiang Shu, Shi-Qiang Shang
Herpangina, usually caused by coxsackie virus A, is prevalent in children spreading through the fecal-oral transmission and the respiratory droplets dissemination. Also, it is mostly asymptomatic and self-limiting. In our study, we found that large outbreak of herpangina in children occurred in the summer of 2015 in Hangzhou, China. From May 1th to August 31th, a total of 10 210 children were diagnosed with herpangina in Children's Hospital of Zhejiang University School of Medicine. 2 310 throat swabs were collected and tested for enterovirus detection by real-time RT-PCR, while 1 651 cases were positive with the rate of 71...
October 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27725476/clinical-features-of-acute-and-fulminant-myocarditis-in-children%C3%A3-2nd-nationwide-survey-by-japanese-society-of-pediatric-cardiology-and-cardiac-surgery
#11
Hiroyuki Matsuura, Fukiko Ichida, Tsutomu Saji, Shunichi Ogawa, Kenji Waki, Masahide Kaneko, Masahiro Tahara, Takashi Soga, Yasuo Ono, Satoshi Yasukochi
BACKGROUND: The 1st nationwide survey by the Japanese Society of Pediatric Cardiology and Cardiac Surgery of acute or fulminant myocarditis (AMC/FMC) in children revealed that the survival rate of FMC was only 51.6%. The 2nd nationwide survey was performed to evaluate the recent outcomes of pediatric myocarditis.Methods and Results:Questionnaires regarding patients aged ≤18 years with AMC/FMC during the period from January 2006 to December 2011 were mailed. A total of 221 cases (age 6...
October 4, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27720179/two-new-mutations-of-the-clmp-gene-identified-in-a-newborn-presenting-congenital-short-bowel-syndrome
#12
Lucile Gonnaud, Maria M Alves, Clara Cremillieux, Kareen Billiemaz, Sylvie Destombe, François Varlet, Manuel Lopez, Laurène Trapes, Renaud Touraine, Robert M W Hofstra, Hugues Patural
Congenital short-bowel syndrome (CSBS) is a rare neonatal pathology associated with poor prognosis and high mortality rate. We describe a newborn presenting CSBS intestinal malrotation and chronic intestinal pseudo-obstruction syndrome (CIPS), compound heterozygous for two previously unreported heterozygous mutations in Coxsackie and adenovirus receptor-like membrane protein (CLMP) gene, one in intron 1 (c.28+1G>C), the other on exon 4 (c502C>T, p.R168X). Both mutations are predicted to be pathogenic, leading to impaired splicing and the appearance of a premature stop codon, respectively...
December 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27687590/fiber-modified-adenovirus-mediated-suicide-gene-therapy-can-efficiently-eliminate-bladder-cancer-cells-in-vitro-and-in-vivo
#13
De Gui Wang, Mei-Jun Zhao, Yong-Qiang Liu, Xiang-Wen Liu, Hai-Tao Niu, Yan-Feng Song, Ying-Xia Tian
Adenovirus-mediated gene therapy is a promising strategy for bladder cancer treatment. However, the loss of the coxsackie and adenovirus receptor (CAR) in bladder cancer cells decreases the infection efficiency of the therapeutic adenovirus. In this study, we constructed an Arg-Gly-Asp (RGD)-modified adenovirus, RGDAd-UPII-TK, that carries a suicide gene called HSV-TK that is driven by a human UPII promoter. Then, we tested the bladder cancer specificity of the UPII promotor and the expression of the HSV-TK protein...
September 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27677239/irreversible-inhibitors-of-the-3c-protease-of-coxsackie-virus-through-templated-assembly-of-protein-binding-fragments
#14
Daniel Becker, Zuzanna Kaczmarska, Christoph Arkona, Robert Schulz, Carolin Tauber, Gerhard Wolber, Rolf Hilgenfeld, Miquel Coll, Jörg Rademann
Small-molecule fragments binding to biomacromolecules can be starting points for the development of drugs, but are often difficult to detect due to low affinities. Here we present a strategy that identifies protein-binding fragments through their potential to induce the target-guided formation of covalently bound, irreversible enzyme inhibitors. A protein-binding nucleophile reacts reversibly with a bis-electrophilic warhead, thereby positioning the second electrophile in close proximity of the active site of a viral protease, resulting in the covalent de-activation of the enzyme...
2016: Nature Communications
https://www.readbyqxmd.com/read/27617209/coxsackie-b5-infection-in-an-adult-with-fever-truncal-rash-diarrhea-and-splenomegaly-with-highly-elevated-ferritin-levels
#15
Paul K Valestra, Scarlet Herrarte Fornos, John Gian, Burke A Cunha
Coxsackie viruses are enteroviruses most common in children. Coxsackie B viral infections often present with biphasic fever, headache, pharyngitis, nausea/vomiting, diarrhea and a maculopapular rash that spares the palms and soles. These clinical features may be present in other viral infections. We present a case of a hospitalized adult with rash and fever with highly elevated ferritin levels later found to be due to Coxsackie B5. We believe this is the first case of Coxsackie B infection with otherwise unexplained highly elevated ferritin levels...
2016: IDCases
https://www.readbyqxmd.com/read/27604323/incomplete-immune-response-to-coxsackie-b-viruses-associates-with-early-autoimmunity-against-insulin
#16
Michelle P Ashton, Anne Eugster, Denise Walther, Natalie Daehling, Stephanie Riethausen, Denise Kuehn, Karin Klingel, Andreas Beyerlein, Stephanie Zillmer, Anette-Gabriele Ziegler, Ezio Bonifacio
Viral infections are associated with autoimmunity in type 1 diabetes. Here, we asked whether this association could be explained by variations in host immune response to a putative type 1 etiological factor, namely coxsackie B viruses (CVB). Heterogeneous antibody responses were observed against CVB capsid proteins. Heterogeneity was largely defined by different binding to VP1 or VP2. Antibody responses that were anti-VP2 competent but anti-VP1 deficient were unable to neutralize CVB, and were characteristic of children who developed early insulin-targeting autoimmunity, suggesting an impaired ability to clear CVB in early childhood...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27583188/current-trends-in-salivary-gland-tight-junctions
#17
REVIEW
Olga J Baker
Tight junctions form a continuous intercellular barrier between epithelial cells that is required to separate tissue spaces and regulate selective movement of solutes across the epithelium. They are composed of strands containing integral membrane proteins (e.g., claudins, occludin and tricellulin, junctional adhesion molecules and the coxsackie adenovirus receptor). These proteins are anchored to the cytoskeleton via scaffolding proteins such as ZO-1 and ZO-2. In salivary glands, tight junctions are involved in polarized saliva secretion and barrier maintenance between the extracellular environment and the glandular lumen...
July 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27580327/absence-of-poliovirus-in-apparently-healthy-school-children-in-bauchi-state-nigeria
#18
Idris Abdullahi Nasir, Muhammad Sagir Shehu, Yunusa Thairu
INTRODUCTION: Poliovirus infections have been established to be in circulation in the remaining three polio-endemic nations. These pathogens have been associated with several chronic diseases, particularly acute flaccid paralysis of children. This study sought to ascertain whether polioviruses are silently shed by apparently healthy schoolchildren in Bauchi, Katagum, and Misau local government areas of Bauchi state, Nigeria. METHODOLOGY: This was a cross-sectional prospective study that involved 200 stool samples collected from apparently healthy schoolchildren...
2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27527752/regulation-of-the-coxsackie-and-adenovirus-receptor-expression-is-dependent-on-cftr-in-airway-epithelial-cells
#19
Anurag Sharma, Yaqin Xu, Biin Sung, Theresa C Vincent, Tilla Worgall, Stefan Worgall
The coxsackievirus and adenovirus receptor (CAR), in addition to serving as viral receptor, is a component of tight junctions and plays an important role in tissue homeostasis. Defects in the cystic fibrosis transmembrane regulator (CFTR) in lung epithelial cells are linked to inflammation and susceptibility for respiratory tract infections. Here we demonstrate that CAR expression and infectivity with adenovirus (Ad) are increased in cystic fibrosis (CF) airway epithelial cells. Inhibition of CFTR or histone deacetylase (HDAC) enhanced CAR expression while CFTR overexpression or restoration of the diminished HDAC activity in CF cells reduced CAR expression...
August 16, 2016: Cellular Microbiology
https://www.readbyqxmd.com/read/27507316/50-years-ago-in-thejournal-ofpediatrics-an-outbreak-of-coxsackie-b-5-virus-infection-in-a-newborn-nursery
#20
Sarah S Long
No abstract text is available yet for this article.
August 2016: Journal of Pediatrics
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