Matthew I Bury, Natalie J Fuller, Xinlong Wang, Yvonne Y Chan, Renea M Sturm, Sang Su Oh, Laurel A Sofer, Hans C Arora, Tiffany T Sharma, Bonnie G Nolan, Wei Feng, Rebecca R Rabizadeh, Milica Barac, Sonia S Edassery, Madeleine M Goedegebuure, Larry W Wang, Balaji Ganesh, Lisa C Halliday, Mark E Seniw, Seby L Edassery, Nadim B Mahmud, Matthias D Hofer, Kevin E McKenna, Earl Y Cheng, Guillermo A Ameer, Arun K Sharma
To date, there are no efficacious translational solutions for end-stage urinary bladder dysfunction. Current surgical strategies, including urinary diversion and bladder augmentation enterocystoplasty (BAE), utilize autologous intestinal segments (e.g. ileum) to increase bladder capacity to protect renal function. Considered the standard of care, BAE is fraught with numerous short- and long-term clinical complications. Previous clinical trials employing tissue engineering approaches for bladder tissue regeneration have also been unable to translate bench-top findings into clinical practice...
February 2024: PNAS Nexus