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Mediastinal tumors

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https://www.readbyqxmd.com/read/29054399/determination-of-molecular-subtypes-of-diffuse-large-b-cell-lymphoma-using-a-reverse-transcriptase-multiplex-ligation-dependent-probe-amplification-classifier-a-calym-study
#1
Victor Bobée, Philippe Ruminy, Vinciane Marchand, Pierre-Julien Viailly, Ahmad Abdel Sater, Liana Veresezan, Fanny Drieux, Caroline Bérard, Elodie Bohers, Sylvain Mareschal, Sydney Dubois, Jean-Philippe Jais, Karen Leroy, Martin Figeac, Jean-Michel Picquenot, Thierry Jo Molina, Gilles Salles, Corinne Haioun, Hervé Tilly, Fabrice Jardin
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. It includes three major subtypes termed germinal center B-cell-like, activated B-cell-like, and primary mediastinal B-cell lymphoma. With the emergence of novel targeted therapies, accurate methods capable of interrogating this cell-of-origin classification should soon become essential in the clinics. To address this issue, we developed a novel gene expression profiling DLBCL classifier based on reverse transcriptase multiplex ligation-dependent probe amplification...
October 13, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29054306/two-stage-surgery-without-parenchyma-resection-for-endobronchial-carcinoid-tumor
#2
Oleg Pikin, Andrey Ryabov, Victor Sokolov, Vladimir Glushko, Konstantin Kolbanov, Larisa Telegina, Ali Amiraliev, Vitaliy Barmin
BACKGROUND: The aim of the study was to evaluate the efficacy of a combined approach of endoscopic resection followed by pure bronchoplasty without any pulmonary resection in patients with endobronchial carcinoids. METHODS: We applied a two-stage technique, endoscopic resection first followed by pure bronchoplasty, to 25 patients (10 men, 15 women) with endobronchial carcinoid tumors. The median age was 32.4 years (range, 19 to 64). The indications for this technique were pure endobronchial carcinoid without lymph node involvement...
October 17, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29040489/palliation-of-anastomotic-tumor-recurrence-after-esophagectomy-and-gastric-transposition-cervico-mediastinal-resection-and-reconstruction-by-using-a-free-jejunal-transplant
#3
M Hermann, H Piza-Katzer, A Leitgeb, S Roka, R Roka
No abstract text is available yet for this article.
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29038400/-surgical-treatment-of-t3-lung-cancer-with-invasion-of-chest-wall-and-other-adjacent-organs
#4
Hirofumi Adachi, Nobuhito Ueda, Yasushi Mizukami, Jun Arikura
We conducted a retrospective investigation in patients who underwent surgery for T3 lung cancer with invasion of chest wall and other adjacent organs. Fifty patients who underwent surgery for T3 lung cancer with invasion of adjacent organs were investigated. The chest wall was the most frequently invaded organ, followed by the pericardium and mediastinal pleura. In cases of chest wall invasion, patients underwent en bloc resection and, when a complete resection was judged feasible, extrapleural resection. Six patients with superior sulcus tumor underwent surgery after preoperative treatment...
October 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29037532/prediction-of-respiratory-collapse-among-pediatric-patients-with-mediastinal-tumors-during-induction-of-general-anesthesia
#5
Yunosuke Kawaguchi, Takeshi Saito, Tetsuya Mitsunaga, Keita Terui, Mitsuyuki Nakata, Gen Matsuura, Katsunori Kouchi, Hideo Yoshida
PURPOSE: Fatality resulting from respiratory collapse (RC) during general anesthesia (GA) induction in children with mediastinal tumors has been reported. We explored potentially useful parameters for predicting the risk of RC based on objective imaging results. METHODS: We retrospectively reviewed the records of 31 patients (median age: 4years; range: 4months-15years) with mediastinal tumors treated between 2000 and 2015. Comparing those with RC under GA induction to those without (RC group vs...
October 2, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29034526/brugada-phenocopy-caused-by-a-compressive-mediastinal-tumor
#6
Andrés R Pérez-Riera, Raimundo Barbosa Barros, Rodrigo Daminello-Raimundo, Marianne P C Resende Barbosa, Luiz C de Abreu
Recently, it has been shown that even experts in electrocardiography cannot differentiate the electrocardiographic pattern of genuine Brugada syndrome (BrS) from Brugada phenocopy (BrP). For this reason, this differentiation depends on the presence of established criteria both for BrS and BrP. In this manuscript, we present a patient with type 1 Brugada electrocardiographic pattern caused by expansive anterior mediastinal non-Hodgkin's lymphoma (NHL) with mechanical compression on the right ventricular outflow tract...
October 15, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29033013/clinical-prognosis-of-superior-versus-basal-segment-stage-i-non-small-cell-lung%C3%A2-cancer
#7
Yoshinori Handa, Yasuhiro Tsutani, Norifumi Tsubokawa, Keizo Misumi, Hideaki Hanaki, Yoshihiro Miyata, Morihito Okada
BACKGROUND: Despite its extensive size, variations in the clinicopathologic features of tumors in the lower lobe have been little studied. The present study investigated the prognostic differences in tumors originating from the superior and basal segments of the lower lobe in patients with non-small cell lung cancer. METHODS: Data of 134 patients who underwent lobectomy or segmentectomy with systematic nodal dissection for clinical stage I, radiologically solid-dominant, non-small cell lung cancer in the superior segment (n = 60) or basal segment (n = 74) between April 2007 and December 2015 were retrospectively reviewed...
October 12, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29032612/correlation-between-cxcr4-cxcr7-cxcl12-chemokine-axis-expression-and-prognosis-in-lymph-node-positive-lung-cancer-patients
#8
Masakazu Katsura, Fumihiro Shoji, Tatsuro Okamoto, Shinichiro Shimamatsu, Fumihiko Hirai, Gouji Toyokawa, Yosuke Morodomi, Tetsuzo Tagawa, Yoshinao Oda, Yoshihiko Maehara
The CXCR4/CXCR7/CXCL12 chemokine axis plays important roles in the migration of tumor cells during cancer development by modulating site-specific distant metastasis including to regional lymph nodes. We investigated the correlation of these chemokine expressions to prognosis in lymph-node-positive non-small-cell lung cancer (NSCLC) patients. A total of 140 surgically resected specimens of primary site (PS) and metastatic lymph nodes (MLN) of NSCLC involving hilar and/or mediastinal lymph nodes (N1-2) were collected...
October 15, 2017: Cancer Science
https://www.readbyqxmd.com/read/29032518/synchronous-solitary-calvarial-yolk-sac-tumor-metastasis-as-the-initial-presentation-of-mediastinal-germ-cell-tumor
#9
Kirti Gupta, Madhivanan Karthigeyan, Ayushman Satapathy, Pravin Salunke
INTRODUCTION: In children, malignant tumors presenting as a calvarial mass that too as initial manifestation are unusual. Also, brain metastases per se are rare in pediatric solid tumors with an incidence of just 1.5%. CASE DESCRIPTION: We present a child with calvarial metastasis which was the presenting symptom of an otherwise asymptomatic large malignant mediastinal germ cell tumor (GCT). The lesion was dural-based involving both calvaria as well as the underlying brain parenchyma...
October 14, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29027754/afatinib-treatment-of-a-squamous-lung-cancer-after-tumor-progression-of-nivolumab
#10
Yinghua Jin, Qiuying Jiang, Tao Xin
Nivolumab prolonged disease control in a patient with advanced squamous lung cancer that was refractory to multiple treatments. The rapid eradication of cancer after the administration of nivolumab caused hemoptysis and repeated infection. Six months after immunotherapy, mediastinal lymph node metastasis developed and afatinib effectively relieved dysphonia associated with nerve paralysis.
October 13, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/29023301/inflammatory-myofibroblastic-tumor-rare-manifestation-in-face
#11
William Phillip Pereira da Silva, Larissa Balbo Zavarez, Fernando Luiz Zanferrari, Juliana Lucena Schussel, Leonardo Pérez Faverani, Juliana Elizabeth Jung, Laurindo Moacir Sassi
Inflammatory myofibroblastic tumor, also known as inflammatory pseudotumor and plasma cell granuloma, is a tumor that occurs most often in the lungs, abdomen, skin, soft tissue, genital system, and mediastinal. Before surgery, the diagnosis is difficult to establish because of its diverse manifestations. In the head and neck, manifestation is rare and may occur in the upper respiratory tract, soft tissues, orbits, and skull base. This article aims to report a rare manifestation of the disease in the face, highlighting the importance of a correct diagnosis to determine the most appropriate form of treatment, in male patient, leucoderma, 22 years old, with complain of a painless unilateral growth in the left cheek, beginning 2 months before and with progressive growth...
October 11, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29021929/rare-presentation-of-a-posterior-mediastinal-cystic-schwannoma-as-a-large-pleural-effusion
#12
Mujtaba Mubashir, Abdus Salam, Amyn Sonawalla, Huma Fatima, Saulat H Fatimi
A 46-year-old man presented with shortness of breath and recurrent, left-sided pleural effusions. A computed tomography (CT) scan of the chest showed a large, left-sided pleural effusion with a mass in the posterior mediastinum. A pleural tap showed lymphocytic exudate. The biopsy of the mass was inconclusive. A left posterolateral thoracotomy was performed, which showed a large posterior mediastinal mass adherent to the left lung. The mass was completely excised and the histopathology proved it to be giant predominantly cystic schwannoma...
August 10, 2017: Curēus
https://www.readbyqxmd.com/read/29021485/spontaneous-regression-of-epithelioid-angiosarcoma-in-a-young-woman
#13
Suya Hori, Motoko Tachihara, Daisuke Tamura, Kazuyuki Kobayashi, Kyosuke Nakata, Hiroshi Kamiryo, Yasuhiro Sakai, Tomoo Itoh, Takanori Hirose, Yoshihiro Nishimura
A 20-year-old Japanese woman with a history of pulmonary atresia was referred to our hospital after the detection of an abnormal mass in the right lung and mediastinal lymphadenopathy. A cytological specimen obtained by transbronchial brushing indicated that the pathological diagnosis was non-small cell lung cancer. During the follow-up period, the tumor spontaneously regressed. At four months after the diagnosis, she experienced sudden bleeding from the small intestine. The histological characteristics of the small intestine tumor were compatible with the cytological characteristics of the lung tumor...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28988295/associations-between-clinical-data-and-computed-tomography-features-in-patients-with-epidermal-growth-factor-receptor-mutations-in-lung-adenocarcinoma
#14
Yiyuan Cao, Haibo Xu, Meiyan Liao, Yanjuan Qu, Liying Xu, Dongyong Zhu, Bicheng Wang, Sufang Tian
BACKGROUND: To analyse the differences in computed tomography (CT) features between patients with lung adenocarcinoma who have epidermal growth factor receptor (EGFR) mutations and those who have wild-type EGFR. METHODS: Patients with lung adenocarcinoma (n = 156) were enrolled from October 2013 to March 2016, including 56 patients with wild-type EGFR and 100 patients with EGFR mutations. Two independent radiologists evaluated patient characteristics and imaging features...
October 7, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28988020/management-of-mediastinal-parathyroid-adenoma-via-minimally-invasive-thoracoscopic-surgery-case-report
#15
Saulat Hasnain Fatimi, Hina Inam, Farida Karim Chagan, Usama Khalid Choudry
INTRODUCTION: The most common cause of chronic hypercalcemia is primary hyperparathyroidism (PHPT). However, owing to the diverse presentation of hypercalcemia, the diagnosis often goes unnoticed culminating as a continuum of recurrence of symptoms. Nephrolithiasis, decreased bone mineral density and peptic ulcer disease are the main clinical sequelae. Among the causes of PHPT 80% are caused by parathyroid adenomas (PA). However, only rarely, these adenomas are found ectopically. PRESENTATION OF CASE: We present the case of a 66-year-old female with a history of recurrent renal stones and peptic ulcer disease...
September 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28986764/predictive-and-prognostic-value-of-18f-dopa-pet-ct-in-patients-affected-by-recurrent-medullary-carcinoma-of-the-thyroid
#16
Federico Caobelli, Agostino Chiaravalloti, Laura Evangelista, Giorgio Saladini, Orazio Schillaci, Manuela Vadrucci, Federica Scalorbi, Davide Donner, Pierpaolo Alongi
INTRODUCTION: Medullary thyroid carcinoma (MTC) is a malignancy accounting for about 5-8% of thyroid cancers. Serum calcitonin and carcinoembryonic antigen (CEA) levels are widely used to monitor disease progression. However, prognostic factors able to predict outcomes are highly desirable. We, therefore, aimed to assess the prognostic role of (18)F-DOPA PET/CT in patients with recurrent MTC. MATERIALS AND METHODS: 60 patients (mean age 64 ± 13 years, range 44-82) with recurrent MTC were eligible from a multicenter database...
October 6, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28976139/cystic-lymphangioma-of-the-lesser-omentum-in-a-pregnant-woman-a-case-report-and-review-of-the-literature
#17
Ozhan Ozdemir, Mustafa Erkan Sarı, Cemal Resat Atalay, Yüksel Kurban, Vusale Asgarova, Devrim Tuba Unal
Lymphangiomas are rare benign tumors which are generally seen in pediatric population and the etiopathogenesis has not yet been understood. They occasionally occur in the head and neck or axillary region with only 5% of them being located in the abdominal or mediastinal cavity. These tumors may be asymptomatic or may cause acute abdominal symptoms due to the location and extention. In the English literature, only 4 cases of lymphangioma were reported to have occurred in the pregnancy period. Herein, we report a case of cystic lymphangioma of the lesser omentum detected incidentally on the ultrasonogram of a 21 year-old, 26-week pregnant woman...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28975027/second-lung-malignancy-and-richter-syndrome-in-chronic-lymphocytic-leukemia-case-report-and-literature-review
#18
Ghassen Soussi, Selsabil Daboussi, Samira Mhamdi, Zied Moatemri, Hela Ghedira, Chiraz Aichaouia, Mohsen Khadhraoui, Faouzi El Mezni, Rezaik Cheikh
BACKGROUND: Chronic lymphocytic leukemia (CLL) is the most frequent lymphoproliferative disease. Transformation into Richter disease and occurrence of second malignancies involving the lungs are rare complications. The hallmarks of any thoracic involvement are still unknown. CASE PRESENTATION: We report a case of a 56-year-old male patient, with history of tobacco smoking, who presented with recurrent hemoptysis, fatigue and weight loss. Physical examination was normal except a slightly enlarged supraclavicular lymph node...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28973110/association-of-pathologic-nodal-staging-quality-with-survival-among-patients-with-non-small-cell-lung-cancer-after-resection-with-curative-intent
#19
Matthew P Smeltzer, Nicholas R Faris, Meredith A Ray, Raymond U Osarogiagbon
Importance: Pathologic nodal stage is the most significant prognostic factor in resectable non-small cell lung cancer (NSCLC). The International Association for the Study of Lung Cancer NSCLC staging project revealed intercontinental differences in N category-stratified survival. These differences may indicate differences not only in cancer biology but also in the thoroughness of the nodal examination. Objective: To determine whether survival was affected by sequentially more stringent definitions of pN staging quality in a cohort of patients with NSCLC after resection with curative intent...
September 28, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28972682/presumed-post-traumatic-ocular-chondrosarcoma-with-intrathoracic-metastases-in-a-cat
#20
Matheus V L Moreira, Maria C de Andrade, Gustavo O Fulgêncio, Ingeborg M Langohr, Roselene Ecco
An indoor-only, 5-year-old, spayed female domestic shorthair cat presented for an ophthalmic examination of the left eye. An intraocular tumor with secondary glaucoma and blindness was diagnosed; the globe was enucleated and sent for histopathological examination. Gross examination revealed a solid white mass filling the entire vitreous space and replacing the iris and ciliary body. The lens and retina appeared to be similarly replaced by the neoplasm. Histological examination revealed a complete loss of the internal ocular structures, with a ruptured capsule as the only remnant of the lens within an extensive malignant mesenchymal neoplastic cell proliferation...
October 3, 2017: Veterinary Ophthalmology
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