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Mediastinal tumors

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https://www.readbyqxmd.com/read/28230028/leucine-rich-repeats-and-immunoglobulin-like-domains-protein-1-and-fascin-actin-bundling-protein-1-expression-in-nonsmall-cell-lung-cancer
#1
Juanjuan Zhang, Xiaoyan Wang, Yijie Zhang, Jingcan Wu, Nannan Zhou
OBJECTIVE: To assess the clinical significance of leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) and fascin actin-bundling protein 1 (Fascin-1) expression in nonsmall cell lung cancer (NSCLC). MATERIALS AND METHODS: Six-one NSCLC patients were included in this study. The expression of LRIG1 and Fascin-1 was assayed in the tumor tissue and relative normal lung tissue of the 61 NSCLC patients by immunohistochemistry. The relationship between LRIG1, Fascin-1 expression pattern and lung cancer patients' clinical pathology characteristics was evaluated...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28223676/-multiple-salvage-radiotherapies-for-metachronous-lymph-node-metastasis-from-gastric-cancer-contributed-to-long-term-management-of-disease
#2
Naoto Hori, Shunsuke Kagawa, Satoru Kikuchi, Shinji Kuroda, Megumi Watanabe, Shuichi Sakamoto, Tetsuya Kagawa, Kazuya Kuwada, Tetsushi Kubota, Hiroyuki Kishimoto, Masahiko Nishizaki, Norihisa Katayama, Toshiyoshi Fujiwara
A 70-year-old man who underwent gastrectomy for Stage III C gastric cancer developed lymph node(LN)metastasis posterior to the pancreatic head 3 years after the radical surgery.He was first treated with radiotherapy(RT)followed by chemotherapy.The irradiated tumor regressed completely.However, the cancer relapsed in a single para-aortic LN and he was treated with RT to the lesion followed by chemotherapy.Although it completely regressed, later, lung metastasis was observed.The lung lesions were well suppressed by switching to docetaxel; however, the cancer relapsed again in a mediastinal LN, and it was not responsive to docetaxel...
February 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28222996/stereotactic-radiation-therapy-for-residual-chemorefractory-primary-mediastinal-non-seminomatous-germ-cell-tumor-after-surgical-thoracotomy
#3
Philippe Laflamme, Cédric Doucet, Christian Sirois, Neil Kopek, Marie Vanhuyse
No abstract text is available yet for this article.
January 7, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28219566/immunoglobulin-g4-related-periaortitis-involving-the-aortic-arch-mimicking-a-mediastinal-tumor
#4
Min Jae Cha, Semin Chong, Yang Soo Kim, Byungjoon Park, Ja Hee Seo, Eun Sung Lee
Immunoglobulin G4 (IgG4)-related sclerosing disease is a recently proposed systemic fibroinflammatory disease entity, with periaortitis as a representative manifestation in the cardiovascular system. We present a case of IgG4-related periaortitis involving the aortic arch and proximal great vessels, mimicking an anterior mediastinal tumor on computed tomography. In patients with a soft tissue mass along the aortic wall, IgG4-related periaortitis should be included as a differential diagnosis and timely serologic investigation should be performed to prevent unnecessary surgery, because the disease shows a remarkable response to corticosteroids...
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28218200/contrast-enhanced-endobronchial-ultrasound-potential-value-of-a-new-method
#5
REVIEW
Christoph F Dietrich
Endobronchial ultrasound (EBUS) has gained importance for mediastinal lymph node staging. Contrast-enhanced EBUS is so far not a discussed technique including contrast-enhanced high mechanical index (MI)-EBUS and potentially contrast-enhanced low MI-EBUS. Possible use could include characterization of mediastinal lymph nodes for better selection of biopsies, differential diagnosis of the primary tumor, and evaluation of thrombosis or tumor in vein infiltration.
January 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28207537/lymph-node-dissection-for-siewert-ii-esophagogastric-junction-adenocarcinoma-a-retrospective-study-of-3-surgical-procedures
#6
Xiao-Feng Duan, Jie Yue, Peng Tang, Xiao-Bin Shang, Hong-Jing Jiang, Zhen-Tao Yu
The present study was aimed to investigate the application of right thansthoracic Ivor-Lewis (IL), left transthoracic (LTT), and left thoracoabdominal (LTA) approach in Siewert type II adenocarcinoma of esophagogastric junction (AEG).The data of 196 patients with Siewert type II AEG received surgical resection in our cancer center between January 2014 and April 2016 was retrospectively analyzed. Finally, 136 patients met the inclusion criteria were enrolled in the study and divided into the IL (47 cases), LTT (51 cases), and LTA group (38 cases)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28206951/missed-lung-cancer-when-where-and-why
#7
Annemilia Del Ciello, Paola Franchi, Andrea Contegiacomo, Giuseppe Cicchetti, Lorenzo Bonomo, Anna Rita Larici
Missed lung cancer is a source of concern among radiologists and an important medicolegal challenge. In 90% of the cases, errors in diagnosis of lung cancer occur on chest radiographs. It may be challenging for radiologists to distinguish a lung lesion from bones, pulmonary vessels, mediastinal structures, and other complex anatomical structures on chest radiographs. Nevertheless, lung cancer can also be overlooked on computed tomography (CT) scans, regardless of the context, either if a clinical or radiological suspect exists or for other reasons...
February 16, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28205418/pediatric-neuroendocrine-carcinoid-tumors-management-pathology-and-imaging-findings-in-a-pediatric-referral-center
#8
Andrew J Degnan, Shannon Tocchio, Waleed Kurtom, Sameh S Tadros
BACKGROUND: While neuroendocrine (carcinoid) tumors are increasingly recognized in the adult population, they are often not suspected in children. PROCEDURE: Retrospective review of all well-differentiated neuroendocrine (carcinoid) tumors was performed based on pathology reports from a quaternary pediatric medical center between January 2003 and June 2016. Clinical presentations, treatment approaches, imaging findings, and outcomes were reviewed and analyzed. RESULTS: A total of 45 cases of pathology-proven carcinoid tumor were reported with an average age of 14...
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28202048/chemotherapy-for-primary-mediastinal-yolk-sac-tumor-in-a-patient-undergoing-chronic-hemodialysis-a-case-report
#9
Haruki Hirakawa, Chiho Nakashima, Tomomi Nakamura, Masanori Masuda, Taro Funakoshi, Shunsaku Nakagawa, Takahiro Horimatsu, Kazuo Matsubara, Manabu Muto, Shinya Kimura, Naoko Sueoka-Aragane
BACKGROUND: The safety and efficacy of chemotherapy for patients undergoing concomitant hemodialysis have not been fully established and optimal doses of anti-cancer drugs and best timing of hemodialysis remains unclear. Although chemosensitive cancers, such as germ cell tumors, treated with chemotherapy should have sufficient dose intensity maintained to achieve the desired effect, many patients with cancer undergoing hemodialysis might be under-treated because the pharmacokinetics of anti-cancer drugs in such patients remains unknown...
February 16, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28196522/xpo1-in-b-cell-hematological-malignancies-from-recurrent-somatic-mutations-to-targeted-therapy
#10
REVIEW
Vincent Camus, Hadjer Miloudi, Antoine Taly, Brigitte Sola, Fabrice Jardin
Many recent publications highlight the large role of the pivotal eukaryotic nuclear export protein exportin-1 (XPO1) in the oncogenesis of several malignancies, and there is emerging evidence that XPO1 inhibition is a key target against cancer. The clinical validation of the pharmacological inhibition of XPO1 was recently achieved with the development of the selective inhibitor of nuclear export compounds, displaying an interesting anti-tumor activity in patients with massive pre-treated hematological malignancies...
February 14, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28194664/phrenic-nerve-stimulation-during-neck-dissection-for-advanced-thyroid-cancer-involving-level-iv-is-it-worth-doing-it
#11
Carlos S Duque, Juan P Dueñas, Marcela Marulanda, Diana Pérez, Andres Londoňo, Soham Roy, Mai Al Khadem
During thyroidectomy and neck dissection surgery for advanced or recurrent metastatic thyroid cancer under intraoperative monitoring, we used the available technology to assess the feasibility of such an intervention to monitor those patients with phrenic nerves at risk. A retrospective review of patients operated on from January 2009 to December 2015 by a single surgeon (CSD) was conducted. Patients who had neck and mediastinal dissection, with or without total thyroidectomy, due to advanced or recurrent metastatic disease to the neck were selected...
February 13, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28194276/a-case-report-of-concurrent-embryonal-rhabdomyosarcoma-and-diffuse-large-b-cell-lymphoma-in-an-adult-without-identifiable-cancer-predisposition
#12
M D Mathias, M V Ortiz, H Magnan, S R Ambati, E K Slotkin, A J Chou, M F Walsh, K Offit, C Moskowitz, A Kentsis, L H Wexler
BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults with around 400 new cases each year in the United States. They have not previously been reported concurrently. CASE PRESENTATION: A 37 year old woman presented with painful enlarging leg mass. Biopsy of the mass was consistent with embryonal rhabdomyosarcoma...
2017: Biomarker Research
https://www.readbyqxmd.com/read/28185421/fine-needle-aspiration-findings-of-xp11-translocation-renal-cell-carcinoma-metastatic-to-a-hilar-lymph-node
#13
Reima El Naili, Marlo Nicolas, Amanda Gorena, Maria Luisa C Policarpio-Nicolas
Xp11 translocation renal cell carcinoma (RCC) is a specific type of renal cell carcinoma recently placed under the "MiT family translocation RCC" at the last 2013 ISUP Vancouver classification of renal neoplasia. This tumor contains variable proportions of clear cells and could easily mimic papillary RCC, clear cell type, and clear cell papillary RCC. Given the small number of published cytologic findings of this tumor, it could easily present as a diagnostic pitfall. We describe a case of a 23-year-old man with a history of prior nephrectomy who presented with multiple mediastinal lymphadenopathies on imaging surveillance follow-up...
February 10, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28183501/an-unusual-cause-of-pulmonary-nodules-after-stem-cell-transplantation
#14
Anna K Brady, Jonathan R Fromm, Siddhartha G Kapnadak
A man in his 20s with a history of classical Hodgkin's lymphoma was admitted with fever. His original lymphoma diagnosis was made 3 years prior, when he had presented with lymphadenopathy and a mediastinal mass. He had relapsed disease despite chemotherapy and radiation. As a result, he underwent autologous peripheral blood stem cell transplant (SCT) 6 months prior to current presentation and subsequently allogeneic SCT 2 months prior for added graft vs tumor effect.
February 2017: Chest
https://www.readbyqxmd.com/read/28176005/prognosis-of-video-assisted-thoracoscopic-pulmonary-metastasectomy-in-patients-with-colorectal-cancer-lung-metastases-an-analysis-of-154-cases
#15
Fenghao Sun, Li Chen, Mengkun Shi, Xiaodong Yang, Ming Li, Xinyu Yang, Xiyu Dai, Cheng Zhan, Yu Shi, Qun Wang
PURPOSE: Video-assisted thoracoscopic surgery (VATS) is widely used in thoracic surgery and increasingly applied to pulmonary metastasectomy. The purpose of this study was to identify prognostic factors of patients undergoing VATS pulmonary metastasectomy from colorectal cancer (CRC). METHODS: Between January 2005 and June 2015, a total of 154 patients underwent VATS pulmonary metastasectomy from CRC. Patient demographic data and characteristics of the primary tumor and pulmonary metastasis were analyzed to identify factors significantly correlated with prognosis...
February 7, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28174385/-long-term-complete-response-in-postoperative-multiple-lung-and-mediastinal-lymph-node-metastases-of-esophageal-cancer-using-systemic-chemotherapy-with-dcf-treatment-a-case-report
#16
Chihiro Katsumi, Takeo Bamba, Satoru Nakagawa, Masaki Aizawa, Atsushi Matsuki, Hiroshi Yabusaki, Keiichi Homma
A 59-year-old man was diagnosed with advanced thoracic esophageal cancer.He underwent neoadjuvant chemotherapy with cisplatin(CDDP), 5-fluorouracil(5-FU)(CF)followed by transthoracic esophagectomy with three-field lymphadenectomy. Histopathological examination revealed that the tumor was poorly differentiated squamous cell carcinoma invading the adventitia with 6 regional lymph node metastases.Four months after surgery, follow-up thoracic computed tomography (CT)showed multiple lung and mediastinal lymph node metastases...
January 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28174383/-a-case-of-synchronous-double-cancer-of-the-lung-and-stomach-that-responded-to-cisplatin-and-s-1-combination-chemotherapy
#17
Tomohide Sugiyama, Takashi Kasai, Yoichi Nakamura, Yukari Kamiyama, Kiyoshi Mori
A 55-year-old man experienced weight loss, as noted by a physician who was examining him for hypertension. Upper gastrointestinal endoscopy revealed a tumor lesion with an ulcer on the posterior wall of the greater curvature. A biopsy confirmed the presence of an adenocarcinoma(HER2 negative), and demonstrated enlarged para-aortic lymph nodes. Thus, stage IV type 3 ulcer infiltration-type gastric cancer was diagnosed. Computed tomography was included in the examination, and demonstrated nodular shadows in the right lower lobe and enlarged mediastinal nodes, as well as bilateral multiple granular shadows...
January 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28174381/-effectiveness-of-nivolumab-in-large-cell-neuroendocrine-carcinoma-of-the-lung-a-report-of-two-cases
#18
Wakako Daido, Masahiro Yamasaki, Naomi Saito, Sayaka Ishiyama, Naoko Deguchi, Masaya Taniwaki, Haruko Daga, Nobuyuki Ohashi
BACKGROUND: The anti-programmed death-1 antibody nivolumab is an important treatment option for non-small-cell lung carcinoma.However, its effectiveness for large-cell neuroendocrine carcinomas(LCNEC)is still controversial.Here, we report 2 cases of LCNECs that responded to nivolumab.Case 1: A 62-year-old man received chemotherapy and radiotherapy for stage III A lung adenocarcinoma.One year later, another lung lesion was observed and diagnosed as LCNEC using surgical lung biopsy.Although he subsequently received some chemotherapy regimens, the patient developed new brain metastasis, expanded mediastinal lesion, and increased levels of the tumor marker pro-gastrin releasing peptide(ProGRP)...
January 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28163719/inferior-vena-cava-and-renal-vein-thrombosis-associated-with-thymic-carcinoma
#19
Vlad Teodor Berbecar, Roxana Jurubita, Marina Paraschiv, Bogdan Obrisca, Bogdan Sorohan, Gener Ismail
Thymic tumors are rare mediastinal tumors that can present with a wide variety of symptoms. They can cause distant manifestations and are frequently associated with paraneoplastic syndromes. In our case, we describe the evolution of a 68-year-old male whose first manifestation was thrombosis of the inferior vena cava and renal veins. Thrombosis of large abdominal veins is rare, especially without being associated with any other comorbidity or risk factors.
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28161346/-hypertestosteronemia-and-infertility-from-a-mediastinal-extragonadal-germ-cell-tumor
#20
Georgios K Dimitriadis, Gregory Kaltsas, Tarek Ghobara, Bidisa Sinha, Eftychia E Drakou, Kishore Gopalakrishnan, Christos Kosmas, Stephen D Keay, Dimitris K Grammatopoulos, Harpal S Randeva
No abstract text is available yet for this article.
February 1, 2017: American Journal of Medicine
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