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https://www.readbyqxmd.com/read/28798359/portable-wireless-electrocorticography-system-with-a-flexible-microelectrodes-array-for-epilepsy-treatment
#1
Kejun Xie, Shaomin Zhang, Shurong Dong, Shijian Li, Chaonan Yu, Kedi Xu, Wanke Chen, Wei Guo, Jikui Luo, Zhaohui Wu
In this paper, we present a portable wireless electrocorticography (ECoG) system. It uses a high resolution 32-channel flexible ECoG electrodes array to collect electrical signals of brain activities and to stimulate the lesions. Electronic circuits are designed for signal acquisition, processing and transmission using Bluetooth Low Energy 4 (LTE4) for wireless communication with cell phone. In-vivo experiments on a rat show that the flexible ECoG system can accurately record electrical signals of brain activities and transmit them to cell phone with a maximal sampling rate of 30 ksampling/s per channel...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797776/increase-in-seizure-susceptibility-in-sepsis-like-condition-explained-by-spiking-cytokines-and-altered-adhesion-molecules-level-with-impaired-blood-brain-barrier-integrity-in-experimental-model-of-rats-treated-with-lipopolysaccharides
#2
Rakesh K Sewal, Manish Modi, Uma Nahar Saikia, Amitava Chakrabarti, Bikash Medhi
BACKGROUND AND OBJECTIVE: Epilepsy is a neurological disorder characterized by recurrent unprovoked seizures. Sepsis is a condition which initiates a cascade of a surge of inflammatory mediators. Interplay between seizures and inflammation other than of brain origin is yet to be explored. The present study was designed to evaluate the seizure susceptibility in experimental models of lipopolysaccharide (LPS) induced sepsis. DESIGN AND METHODS: Experimental sepsis was induced using lipopolysaccharides in Wistar rats...
June 15, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28794634/erratum-involvement-of-up-regulation-of-mir-210-in-a-rat-epilepsy-model-corrigendum
#3
(no author information available yet)
[This corrects the article on p. 1731 in vol. 12, PMID: 27471387.].
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28794441/tgf%C3%AE-signaling-is-associated-with-changes-in-inflammatory-gene-expression-and-perineuronal-net-degradation-around-inhibitory-neurons-following-various-neurological-insults
#4
Soo Young Kim, Vladimir V Senatorov, Christapher S Morrissey, Kristina Lippmann, Oscar Vazquez, Dan Z Milikovsky, Feng Gu, Isabel Parada, David A Prince, Albert J Becker, Uwe Heinemann, Alon Friedman, Daniela Kaufer
Brain damage due to stroke or traumatic brain injury (TBI), both leading causes of serious long-term disability, often leads to the development of epilepsy. Patients who develop post-injury epilepsy tend to have poor functional outcomes. Emerging evidence highlights a potential role for blood-brain barrier (BBB) dysfunction in the development of post-injury epilepsy. However, common mechanisms underlying the pathological hyperexcitability are largely unknown. Here, we show that comparative transcriptome analyses predict remodeling of extracellular matrix (ECM) as a common response to different types of injuries...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28793299/the-effects-of-adenosinergic-modulation-on-cytokine-levels-in-a-pentylenetetrazole-induced-generalized-tonic-clonic-seizure-model
#5
Fazilet Dede, Sabriye Karadenizli, Özgür Doğa Özsoy, Fatma Ceyla Eraldemir, Deniz Şahin, Nurbay Ateş
OBJECTIVE: It has been suggested that the adenosinergic system and cytokines play a role in the pathogenesis of epilepsy. Although the role of the adenosinergic system in the modulation of seizure activity is well known, the mechanism of this modulation needs to be described in detail. We performed this study to determine the contribution of the proinflammatory cytokines to the generalized seizure activity during adenosine and caffeine treatment. METHODS: We induced generalized tonic-clonic seizures with the administration of 60 mg/kg pentylenetetrazole (PTZ) in male Wistar Albino rats...
August 10, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28790891/adenosine-a1-receptor-antagonism-abolished-the-anti-seizure-effects-of-exogenous-ketone-supplementation-in-wistar-albino-glaxo-rijswijk-rats
#6
Zsolt Kovács, Dominic P D'Agostino, Arpád Dobolyi, Csilla Ari
The state of therapeutic ketosis can be achieved by using the ketogenic diet (KD) or exogenous ketone supplementation. It was suggested previously that the adenosinergic system may be involved in the mediating effect of KD on suppressing seizure activity in different types of epilepsies, likely by means of adenosine A1 receptors (A1Rs). Thus, we tested in the present study whether exogenous ketone supplements (ketone ester: KE, 2.5 g/kg/day; ketone salt/KS + medium chain triglyceride/MCT: KSMCT, 2.5 g/kg/day) applied sub-chronically (for 7 days) by intragastric gavage can modulate absence epileptic activity in genetically absence epileptic Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28783762/using-postmortem-hippocampi-tissue-can-interfere-with-differential-gene-expression-analysis-of-the-epileptogenic-process
#7
João Paulo Lopes Born, Heloisa de Carvalho Matos, Mykaella Andrade de Araujo, Olagide Wagner Castro, Marcelo Duzzioni, José Eduardo Peixoto-Santos, João Pereira Leite, Norberto Garcia-Cairasco, Maria Luisa Paçó-Larson, Daniel Leite Góes Gitaí
Neuropathological studies often use autopsy brain tissue as controls to evaluate changes in protein or RNA levels in several diseases. In mesial temporal lobe epilepsy (MTLE), several genes are up or down regulated throughout the epileptogenic and chronic stages of the disease. Given that postmortem changes in several gene transcripts could impact the detection of changes in case-control studies, we evaluated the effect of using autopsy specimens with different postmortem intervals (PMI) on differential gene expression of the Pilocarpine (PILO)induced Status Epilepticus (SE) of MTLE...
2017: PloS One
https://www.readbyqxmd.com/read/28777257/chronic-levetiracetam-decreases-hippocampal-and-testicular-aromatase-expression-in-normal-but-not-kainic-acid-induced-experimental-model-of-acute-seizures-in-rats
#8
Mehtap Cincioğlu-Palabiyik, Meral Üner, Dilek Ertoy-Baydar, Yildirim Sara, Hande Karahan, Pelin Kelicen-Uğur
Reproductive disorders are more common in men with epilepsy taking anticonvulsant medications. Antiseizure/anticonvulsant drugs and seizures in medial temporal lobe structures may cause gonadal dysfunction, including infertility, decreased libido, and potency. Levels of circulating bioavailable testosterone are affected by the aromatase enzyme, which converts testosterone into estrogen and may be affected by seizure medications. However, the relationship of anticonvulsant drugs with central aromatase levels is not clear...
August 2, 2017: Neuroreport
https://www.readbyqxmd.com/read/28776277/anti-epileptic-activity-of-nelumbo-nucifera-fruit
#9
Muhammad Ali Rajput, Rafeeq Alam Khan, Tahira Assad
Epilepsy is the most commonly encountered neurological disorder affecting around 70 million people worldwide, out of which approximately 80% belongs to developing countries. Several shortcomings appeared with the use of conventional antiepileptic agents like, inadequate seizure control, side effects and cost which limit their use. Thus extensive studies are necessary to investigate the pharmacological effects of plants, which would facilitate discovery of novel drugs from herbal source permitting their use to benefit mankind...
August 3, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28772197/effects-of-acute-physical-exercise-in-the-light-phase-of-sleep-in-rats-with-temporal-lobe-epilepsy
#10
Cristiano de Lima, Ricardo Mario Arida, Monica Levy Andersen, Daniel Ninello Polesel, Tathiana Aparecida Fernandes de Alvarenga, Rodrigo Luiz Vancini, Gabriela Matos, Sergio Tufik
OBJECTIVE: Our aim was to investigate the influence of an acute exercise session on sleep pattern in rats with temporal lobe epilepsy (TLE). METHODS: Twenty male Wistar rats were randomly assigned to 4 groups: control (C); acute exercise (EX); epilepsy (E) and epilepsy acute exercise (EEX). Two sleep electrocorticography recordings were performed during the light phase [baseline and day 2 (after the acute physical exercise session)]. After baseline recording, the exercise groups (EX and EEX) were submitted to an exercise session on a motor-driven treadmill at 12m/min for 30min...
July 21, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28772144/epileptic-rat-brain-tissue-analyzed-by-2d-correlation-raman-spectroscopy
#11
Julia Sacharz, Aleksandra Wesełucha-Birczyńska, Janina Zięba-Palus, Marian H Lewandowski, Rafał Kowalski, Katarzyna Palus, Łukasz Chrobok, Paulina Moskal, Malwina Birczyńska, Agnieszka Sozańska
Absence epilepsy is the neurological disorder characterized by the pathological spike-and wave discharges present in the electroencephalogram, accompanying a sudden loss of consciousness. Experiments were performed on brain slices obtained from young male WAG/Rij rats (2-3weeks old), so that they were sampled before the appearance of brain-damaging seizures symptoms. Two differing brain areas of the rats' brain tissue were studied: the somatosensory cortex (Sc) and the dorsal lateral geniculate nucleus of the thalamus (DLG)...
July 25, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28764934/effects-of-anterior-thalamic-nuclei-deep-brain-stimulation-on-neurogenesis-in-epileptic-and-healthy-rats
#12
Ying-Chuan Chen, Lin Shi, Guan-Yu Zhu, Xiu Wang, De-Feng Liu, Yu-Ye Liu, Yin Jiang, Xin Zhang, Jian-Guo Zhang
BACKGROUND: The efficacy of anterior thalamic nuclei (ANT) deep brain stimulation (DBS) in mitigating epileptic seizures has been established. Though the neuroprotection of ANT-DBS has been illustrated, the seizure mitigating mechanism of ANT-DBS has not been thoroughly elucidated. In particular, the effect of ANT-DBS on neurogenesis has not been reported previously. METHOD: Thirty-two male Sprague Dawley rats were randomly assigned to the following groups: sham-DBS-healthy (HL) (n=8), DBS-HL (n=8), sham-DBS-epilepsy (EP) (n=8) and DBS-EP (n=8)...
July 29, 2017: Brain Research
https://www.readbyqxmd.com/read/28760863/acute-increases-in-protein-o-glcnacylation-dampen-epileptiform-activity-in-hippocampus
#13
L T Stewart, A U Khan, K Wang, D Pizarro, S Pati, S C Buckingham, M L Olsen, J C Chatham, L L McMahon
O-GlcNAcylation is a ubiquitous and dynamic posttranslational modification involving the O-linkage of β-N-acetylglucosamine to serine/threonine residues of membrane, cytosolic, and nuclear proteins. This modification is similar to phosphorylation, and regarded as a key regulator of cell survival and homeostasis. Previous studies have shown that phosphorylation of serine residues on synaptic proteins is a major regulator of synaptic strength and long-term plasticity, suggesting O-GlcNAcylation of synaptic proteins is likely as important as phosphorylation; however, few studies have investigated its role in synaptic efficacy...
July 31, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28758946/hippocampal-proteome-of-rats-subjected-to-the-li-pilocarpine-epilepsy-model-and-the-effect-of-carisbamate-treatment
#14
José Eduardo Marques-Carneiro, Daniele Suzete Persike, Julia Julie Litzahn, Jean-Christophe Cassel, Astrid Nehlig, Maria José da Silva Fernandes
In adult rats, the administration of lithium-pilocarpine (LiPilo) reproduces most clinical and neuropathological features of human temporal lobe epilepsy (TLE). Carisbamate (CRS) possesses the property of modifying epileptogenesis in this model. Indeed, about 50% of rats subjected to LiPilo status epilepticus (SE) develop non-convulsive seizures (NCS) instead of motor seizures when treated with CRS. However, the mechanisms underlying these effects remain unknown. The aim of this study was to perform a proteomic analysis in the hippocampus of rats receiving LiPilo and developing motor seizures or NCS following CRS treatment...
July 30, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28757050/electroencephalographic-cognitive-and-neurochemical-effects-of-ly3130481-cerc-611-a-selective-antagonist-of-tarp-%C3%AE-8-associated-ampa-receptors
#15
Jeffrey M Witkin, Jennifer Li, Gary Gilmour, Stephen N Mitchell, Guy Carter, Scott D Gleason, Wesley F Seidel, Brian J Eastwood, Andrew McCarthy, Warren J Porter, Jon Reel, Kevin M Gardinier, Akihiko S Kato, Keith A Wafford
6-[(1S)-1-[1-[5-(2-hydroxyethoxy)-2-pyridyl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one (LY3130481 or CERC-611) is a selective antagonist of AMPA receptors containing transmembrane AMPA receptor regulatory protein (TARP) γ-8. This molecule has been characterized as a potent and efficacious anticonvulsant in an array of acute and chronic epilepsy models in rodents. The present set of experiments was designed to assess the effects of LY3130481 on the electroencephelogram (EEG), cognitive function, and neurochemical outflow...
July 27, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28753497/disease-modifying-effect-of-atipamezole-in-a-model-of-post-traumatic-epilepsy
#16
Jari Nissinen, Pedro Andrade, Teemu Natunen, Mikko Hiltunen, Tarja Malm, Katja Kanninen, Joana I Soares, Olena Shatillo, Jukka Sallinen, Xavier Ekolle Ndode-Ekane, Asla Pitkänen
Treatment of TBI remains a major unmet medical need, with 2.5 million new cases of traumatic brain injury (TBI) each year in Europe and 1.5 million in the USA. This single-center proof-of-concept preclinical study tested the hypothesis that pharmacologic neurostimulation with proconvulsants, either atipamezole, a selective α2-adrenoceptor antagonist, or the cannabinoid receptor 1 antagonist SR141716A, as monotherapy would improve functional recovery after TBI. A total of 404 adult Sprague-Dawley male rats were randomized into two groups: sham-injured or lateral fluid-percussion-induced TBI...
July 12, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28751143/n-alkyl-1-1-biphenyl-2-sulfonamide-derivatives-as-novel-broad-spectrum-anti-epileptic-drugs-with-efficacy-equivalent-to-that-of-sodium-valproate
#17
Tomoyuki Tanaka, Nana Yajima, Tomoko Kiyoshi, Yoshiki Miura, Seiji Iwama
In order to develop phenyl sulfonamides as a novel class of anti-epileptic drugs (AED) for both general and partial seizure, we initiated in vivo screening of our chemical library in the mice MES and sc-PTZ models and found compounds 1 and 2 as lead compounds. Optimization of 1 and 2 led to the discovery of compound 21, which showed potent anticonvulsant effect in MES, scPTZ and rat amygdala kindling models. These findings indicate that compound 21 could be a useful new broad spectrum AED like sodium valproate and provide an opportunity to struggle current therapy-resistant epilepsy...
July 13, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28742194/dynamic-regulation-effect-of-long-non-coding-rna-uca1-on-nf-kb-in-hippocampus-of-epilepsy-rats
#18
H-K Wang, H Yan, K Wang, J Wang
OBJECTIVE: We aimed to discuss the mechanism of occurrence and progression of epilepsy through analyzing the expression changes of UCA1 and NF-Kb in temporal hippocampus and UCA1 in peripheral blood in rats with epilepsy induced by lithium chloride-pilocarpine. MATERIALS AND METHODS: The lithium chloride-pilocarpine-induced epilepsy rat model was established; 1, 7, 14, 30, and 60 d after status epilepticus were selected as the time points of research. The expression levels of UCA1 and NF-kB in the hippocampus of rats and UCA1 in peripheral blood were detected and analyzed using quantitative Real-time PCR (qRT-PCR)...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28740261/sustained-efficacy-of-closed-loop-electrical-stimulation-for-long-term-treatment-of-absence-epilepsy-in-rats
#19
Gábor Kozák, Antal Berényi
Closed-loop brain stimulation is a promising alternative to treat drug-resistant epilepsies. In contrast to optogenetic interventions, transcranial electrical stimulation (TES) does not require cellular modification of neurons to be effective, and it is less invasive compared to deep brain stimulation. Furthermore, on-demand TES of targeted brain regions allows the potential for normal function of these networks during interictal periods, a possibility that is eliminated by resective surgical treatment approaches...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28725010/glucose-deficiency-elevates-acid-sensing-ion-channel-2a-expression-and-increases-seizure-susceptibility-in-temporal-lobe-epilepsy
#20
Haitao Zhang, Guodong Gao, Yu Zhang, Yang Sun, Huanfa Li, Shan Dong, Wei Ma, Bei Liu, Weiwen Wang, Hao Wu, Hua Zhang
Brain hypometabolism is a common epilepsy-related finding in both patients and animal models. Fluorodeoxyglucose positron emission tomography studies have shown that recurrent seizures lead to reduced glucose metabolism in certain brain regions, but no studies have definitively determined whether this induces epileptogenesis. There is evidence that acid-sensing ion channel 2a (ASIC2a) affects epilepsy susceptibility. Transcription factor CP2 (TFCP2) regulates ASIC2a expression. We report that suppressed TFCP2 expression and elevated ASIC2a expression were associated with glucose hypometabolism in the hippocampi of humans with epilepsy and of rat epilepsy model brains...
July 19, 2017: Scientific Reports
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