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Follicular t helper cell

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https://www.readbyqxmd.com/read/29449847/potential-epigenetic-regulation-in-the-germinal-center-reaction-of-lymphoid-tissues-in-hiv-siv-infection
#1
REVIEW
Xiaolei Wang, Huanbin Xu
The production of high-affinity and broadly neutralizing antibodies plays a key role in the defense against pathogens. These antibody responses require effective germinal center (GC) reaction within anatomical niches of GCs, where follicular helper T (Tfh) cells provide cognate help to B cells for T cell-dependent antibody responses. Emerging evidences indicate that GC reaction in normal state and perhaps establishment of latent Tfh cell reservoir in HIV/SIV infection are tightly regulated by epigenetic histone modifications, which are responsible for activating or silencing chromatin...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29444980/circulating-t-fh-cells-serological-memory-and-tissue-compartmentalization-shape-human-influenza-specific-b-cell-immunity
#2
Marios Koutsakos, Adam K Wheatley, Liyen Loh, E Bridie Clemens, Sneha Sant, Simone Nüssing, Annette Fox, Amy W Chung, Karen L Laurie, Aeron C Hurt, Steve Rockman, Martha Lappas, Thomas Loudovaris, Stuart I Mannering, Glen P Westall, Michael Elliot, Stuart G Tangye, Linda M Wakim, Stephen J Kent, Thi H O Nguyen, Katherine Kedzierska
Immunization with the inactivated influenza vaccine (IIV) remains the most effective strategy to combat seasonal influenza infections. IIV activates B cells and T follicular helper (T FH ) cells and thus engenders antibody-secreting cells and serum antibody titers. However, the cellular events preceding generation of protective immunity in humans are inadequately understood. We undertook an in-depth analysis of B cell and T cell immune responses to IIV in 35 healthy adults. Using recombinant hemagglutinin (rHA) probes to dissect the quantity, phenotype, and isotype of influenza-specific B cells against A/California09-H1N1, A/Switzerland-H3N2, and B/Phuket, we showed that vaccination induced a three-pronged B cell response comprising a transient CXCR5 - CXCR3 + antibody-secreting B cell population, CD21 hi CD27 + memory B cells, and CD21 lo CD27 + B cells...
February 14, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29440671/impaired-airway-mucociliary-function-reduces-antigen-specific-iga-immune-response-to-immunization-with-a-claudin-4-targeting-nasal-vaccine-in-mice
#3
Hidehiko Suzuki, Takahiro Nagatake, Ayaka Nasu, Huangwenxian Lan, Koji Ikegami, Mitsutoshi Setou, Yoko Hamazaki, Hiroshi Kiyono, Kiyohito Yagi, Masuo Kondoh, Jun Kunisawa
Vaccine delivery is an essential element for the development of mucosal vaccine, but it remains to be investigated how physical barriers such as mucus and cilia affect vaccine delivery efficacy. Previously, we reported that C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) targeted claudin-4, which is expressed by the epithelium associated with nasopharynx-associated lymphoid tissue (NALT), and could be effective as a nasal vaccine delivery. Mice lacking tubulin tyrosine ligase-like family, member 1 (Ttll1-KO mice) showed mucus accumulation in nasal cavity due to the impaired motility of respiratory cilia...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29440270/correction-stat4-and-t-bet-control-follicular-helper-t-cell-development-in-viral-infections
#4
Jason S Weinstein, Brian J Laidlaw, Yisi Lu, Jessica K Wang, Vincent P Schulz, Ningcheng Li, Edward I Herman, Susan M Kaech, Patrick G Gallagher, Joe Craft
No abstract text is available yet for this article.
February 13, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29437871/gut-microbiota-modulate-t-cell-trafficking-into-human-colorectal-cancer
#5
Eleonora Cremonesi, Valeria Governa, Jesus Francisco Glaus Garzon, Valentina Mele, Francesca Amicarella, Manuele Giuseppe Muraro, Emanuele Trella, Virginie Galati-Fournier, Daniel Oertli, Silvio Raffael Däster, Raoul A Droeser, Benjamin Weixler, Martin Bolli, Raffaele Rosso, Ulrich Nitsche, Nina Khanna, Adrian Egli, Simone Keck, Julia Slotta-Huspenina, Luigi M Terracciano, Paul Zajac, Giulio Cesare Spagnoli, Serenella Eppenberger-Castori, Klaus-Peter Janssen, Lubor Borsig, Giandomenica Iezzi
OBJECTIVE: Tumour-infiltrating lymphocytes (TILs) favour survival in human colorectal cancer (CRC). Chemotactic factors underlying their recruitment remain undefined. We investigated chemokines attracting T cells into human CRCs, their cellular sources and microenvironmental triggers. DESIGN: Expression of genes encoding immune cell markers, chemokines and bacterial 16S ribosomal RNA (16SrRNA) was assessed by quantitative reverse transcription-PCR in fresh CRC samples and corresponding tumour-free tissues...
February 6, 2018: Gut
https://www.readbyqxmd.com/read/29426881/activated-t-follicular-helper-like-cells-are-released-into-blood-after-oral-vaccination-and-correlate-with-vaccine-specific-mucosal-b-cell-memory
#6
Ana Cárdeno, Maria K Magnusson, Marianne Quiding-Järbrink, Anna Lundgren
T follicular helper (Tfh)-like cells with potent B-cell helping ability are mobilized into human circulation after parenteral vaccination and are generally held to reflect ongoing germinal center reactions. However, whether mucosal vaccination induces systemic Tfh responses and how such responses may relate to IgA production are unknown. We investigated the frequencies, phenotype and function of circulating Tfh-like CD4+CXCR5+ T cells (cTfh) in adults receiving an oral inactivated enterotoxigenic Escherichia coli vaccine...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29422894/the-b-cell-follicle-in-hiv-infection-barrier-to-a-cure
#7
REVIEW
Matthew P Bronnimann, Pamela J Skinner, Elizabeth Connick
The majority of HIV replication occurs in secondary lymphoid organs (SLOs) such as the spleen, lymph nodes, and gut-associated lymphoid tissue. Within SLOs, HIV RNA+ cells are concentrated in the B-cell follicle during chronic untreated infection, and emerging data suggest that they are a major source of replication in treated disease as well. The concentration of HIV RNA+ cells in the B-cell follicle is mediated by several factors. Follicular CD4+ T-cell subsets including T-follicular helper cells and T-follicular regulatory cells are significantly more permissive to HIV than extrafollicular subsets...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29414660/increased-circulating-cd4-cxcr5-foxp3-follicular-regulatory-t-cells-correlated-with-severity-of-systemic-lupus-erythematosus-patients
#8
Chen Liu, Dongwei Wang, Ying Song, Songsong Lu, Jingzhong Zhao, Hui Wang
As one specialized subset of regulatory T cells (Tregs), follicular regulatory T cells (TFR) could suppress follicular helper T cells (TFH) and B cells in germinal centers to maintain immune homeostasis. The unbalance of TFR and TFH cells could result in abnormal germinal center responses and contribute to pathogenesis of autoimmune diseases. However, the role of TFR cells in systemic lupus erythematosus (SLE) remains unclear. This study revealed a significant increase of CD4+CXCR5+FOXP3+ TFR cells in peripheral blood of SLE patients compared with healthy controls...
January 30, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29409739/expansion-of-circulating-t-follicular-helper-cells-is-associated-with-disease-progression-in-hiv-infected-individuals
#9
Jianhua Lu, Ying Lv, Zhuo Lv, Yi Xu, Yan Huang, Meilan Cui, Huimin Yan
BACKGROUND: T follicular helper (Tfh) cells within germinal centers (GC) of lymphoid tissue play an important role in HIV infection. Recently, circulating Tfh cells have been described, which share phenotypic and functional characteristics with GC Tfh cells. This study aimed to investigate the effect of HIV infection on four circulating Tfh subsets, including CD4+CXCR5+, CD4+CXCR5+ICOS+, CD4+CXCR5+PD-1+, and CD4+CXCR5+ICOS+PD-1+ cells. PATIENTS AND METHODS: Peripheral blood samples were collected from 33 HIV-infected individuals and 21 healthy controls...
February 3, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29398449/rhoa-g17v-induces-t-follicular-helper-cell-specification-and-promotes-lymphomagenesis
#10
Jose R Cortes, Alberto Ambesi-Impiombato, Lucile Couronné, S Aidan Quinn, Christine S Kim, Ana C da Silva Almeida, Zachary West, Laura Belver, Marta Sanchez Martin, Laurianne Scourzic, Govind Bhagat, Olivier A Bernard, Adolfo A Ferrando, Teresa Palomero
Angioimmunoblastic T cell lymphoma (AITL) is an aggressive tumor derived from malignant transformation of T follicular helper (Tfh) cells. AITL is characterized by loss-of-function mutations in Ten-Eleven Translocation 2 (TET2) epigenetic tumor suppressor and a highly recurrent mutation (p.Gly17Val) in the RHOA small GTPase. Yet, the specific role of RHOA G17V in AITL remains unknown. Expression of Rhoa G17V in CD4+ T cells induces Tfh cell specification; increased proliferation associated with inducible co-stimulator (ICOS) upregulation and increased phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase signaling...
February 1, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29396703/immunologic-milieu-of-mature-t-cell-and-nk-cell-lymphomas-implications-for-therapy
#11
REVIEW
Eric Tse, Yok-Lam Kwong
PURPOSE OF THE REVIEW: T-cells and natural killer (NK) cells share the same ontogeny, and lymphomas derived from them are clinically diverse, occurring in nodal and extranodal sites. In addition to inherent properties of these lymphomas, their microenvironment also impacts on pathogenesis and response to therapy. An understanding of the milieu of T-cell and NK cell lymphomas has important implications on treatment. RECENT FINDINGS: Components of the microenvironment include tumour-associated macrophages (TAM), non-neoplastic T-cells and B-cells, eosinophils, dendritic cells, endothelial cells and blood vessels...
February 2, 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29396161/b-cell-receptor-and-cd40-signaling-are-rewired-for-synergistic-induction-of-the-c-myc-transcription-factor-in-germinal-center-b-cells
#12
Wei Luo, Florian Weisel, Mark J Shlomchik
Positive selection of germinal center (GC) B cells is driven by B cell receptor (BCR) affinity and requires help from follicular T helper cells. The transcription factors c-Myc and Foxo1 are critical for GC B cell selection and survival. However, how different affinity-related signaling events control these transcription factors in a manner that links to selection is unknown. Here we showed that GC B cells reprogram CD40 and BCR signaling to transduce via NF-κB and Foxo1, respectively, whereas naive B cells propagate both signals downstream of either receptor...
January 26, 2018: Immunity
https://www.readbyqxmd.com/read/29388103/ex-vivo-culture-assay-to-measure-human-follicular-helper-t-tfh-cell-mediated-human-b-cell-proliferation-and-differentiation
#13
Xin Gao, Lin Lin, Di Yu
Upon priming by antigens, B cells undergo activation, proliferation, and differentiation into antibody-secreting cells. During thymus-dependent (TD) antibody responses, the proliferation and differentiation of antigen-primed B cells essentially rely on the helper function from CD4+ T cells. Follicular helper T (Tfh) cells constitute a specialized Th subset that localizes in close proximity to B cells and supports B cell proliferation and differentiation through co-stimulatory receptors and cytokines. Impaired Tfh-mediated B cell proliferation and differentiation were observed in patients with immunodeficiency, while overactivation of this process may lead to dysregulated immune responses seen in autoimmune disorders...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29388097/analyzing-mouse-b-cell-responses-specific-to-lcmv-infection
#14
Yaxing Hao, Zhirong Li, Yifei Wang, Xiaobing Liu, Lilin Ye
B cell responses play a central role in humoral immunity, which protects an individual from invading pathogens by antigen-specific antibodies. Understanding the basic principles of the B cell responses during viral infection is of substantial importance for anti-viral vaccine development. In inbred mice, lymphocytic choriomeningitis virus (LCMV) infection elicits robust and typical T cell-dependent B cell responses, including germinal center reaction, memory B cell formation, and a long-lived plasma cell pool in bone marrow...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29381842/increased-circulating-follicular-regulatory-t-cells-are-associated-with-lower-auto-antibodies-in-stable-remission-rheumatoid-arthritis-patients
#15
Chen Liu, Dongwei Wang, Songsong Lu, Qinzhu Xu, Lei Zhao, Jingzhong Zhao, Ying Song, Hui Wang
OBJECTIVE: To examine expression and function changes of circulating CD4+ CXCR5+ FoxP3+ Follicular regulatory T (TFR) cells in active and stable remission rheumatoid arthritis (RA) patients and to clarify the role of TFR cells in the pathogenesis of RA. METHODS: TFR and follicular helper T cells (TFH) levels in peripheral blood of 39 active RA patients, 39 stable remission RA patients and 33 healthy controls were detected by flow cytometry. The function of TFR cells was measured by co-culturing with TFH and B cells...
January 30, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29380399/immunohistochemical-assessment-of-the-diagnostic-utility-of-pd-l1-a-preliminary-analysis-of-anti-pd-l1-antibody-sp142-for-lymphoproliferative-diseases-with-tumour-and-nonmalignant-hodgkin-reed-sternberg-hrs-like-cells
#16
Ayako Sakakibara, Kei Kohno, Ahmed E Eladl, Teerada Klaisuwan, Eri Ishikawa, Yuka Suzuki, Satoko Shimada, Masato Nakaguro, Yoshie Shimoyama, Taishi Takahara, Seiichi Kato, Naoko Asano, Shigeo Nakamura, Akira Satou
AIMS: The programmed death 1 (PD1)/PD1 ligand (PD-L1) axis plays an important role in tumour cells escape from immune control. PD-L1 immunohistochemistry is a useful predictor of immunotherapy response, but is still not widely used in the diagnostic setting. Here we describe results using PD-L1 immunohistochemistry during routine diagnostics in lymphoma. METHODS AND RESULTS: Ninety-one lymphoproliferative disease cases sharing tumour and nonmalignant Hodgkin/Reed-Sternberg (HRS)-like cells with and without Epstein-Barr virus (EBV) association were investigated by immunohistochemistry for PD-L1 (clone SP142)...
January 30, 2018: Histopathology
https://www.readbyqxmd.com/read/29377743/leptin-upregulates-peripheral-cd4-cxcr5-icos-t-cells-via-increased-il-6-in-rheumatoid-arthritis-patients
#17
Miaomiao Wang, Jing Wei, Han Li, Xunli Ouyang, Xiaotong Sun, Yawei Tang, Haifeng Chen, Bing Wang, Xia Li
CD4+CXCR5+ICOS+ T cells, known as Tfh (T Follicular helper) cells, are required for antibody production. Abnormal production and differentiation of Tfh cells are involved in many autoimmune diseases, including rheumatoid arthritis (RA). Leptin has the property of modulating immune system. Here, we explored the effect of leptin on CD4+CXCR5+ICOS+ T cells production in RA patients. Serum leptin levels were measured by enzyme-linked immunosorbent assay (ELISA). Peripheral blood mononuclear cells (PBMC) stimulated with CD3/CD28 were cultured in the presence and absence of leptin and with or without anti-IL-6 receptor (anti-IL-6R), anti-IL-21R, and anti-IL-12R antibody respectively...
January 29, 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29365488/marginal-zone-b-cells-control-follicular-helper-t-cell-response-to-high-cholesterol-diet
#18
Meritxell Nus, Andy P Sage, Yuning Lu, Leanne Masters, Brian Yh Lam, Stephen Newland, Sandra Weller, Dimitrios Tsiantoulas, Juliette Raffort, Damienne Marcus, Alison Finigan, Lauren Kitt, Nichola Figg, Reinhold Schirmbeck, Manfred Kneilling, Giles Sh Yeo, Christoph J Binder, Jose L De La Pompa, Ziad Mallat
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29365313/the-human-il-15-superagonist-alt-803-directs-siv-specific-cd8-t-cells-into-b-cell-follicles
#19
Gabriela M Webb, Shengbin Li, Gwantwa Mwakalundwa, Joy M Folkvord, Justin M Greene, Jason S Reed, Jeffery J Stanton, Alfred W Legasse, Theodore Hobbs, Lauren D Martin, Byung S Park, James B Whitney, Emily K Jeng, Hing C Wong, Douglas F Nixon, R Brad Jones, Elizabeth Connick, Pamela J Skinner, Jonah B Sacha
Sequestering of latent HIV in follicular helper T cells within B-cell follicles that largely exclude cytotoxic T cells is a major barrier to cellular immune-based approaches to eradicate HIV. Here, we show that the clinical-grade human interleukin-15 (IL-15) superagonist ALT-803 activates and redirects simian immunodeficiency virus (SIV)-specific CD8+ T cells from the peripheral blood into B-cell follicles. In agreement with the increased trafficking of SIV-specific cytotoxic T cells to sites of cryptic viral replication, lymph nodes of elite controlling macaques contained fewer cells expressing SIV RNA or harboring SIV DNA post-ALT-803 treatment...
January 23, 2018: Blood Advances
https://www.readbyqxmd.com/read/29361207/blood-t-follicular-regulatory-cells-t-follicular-helper-cells-ratio-marks-ectopic-lymphoid-structure-formation-and-pd-1-icos-t-follicular-helper-cells-indicate-disease-activity-in-primary-sj%C3%A3-gren-s-syndrome
#20
Valter R Fonseca, Vasco C Romão, Ana Agua-Doce, Mara Santos, Dolores López-Presa, Ana Cristina Ferreira, João Eurico Fonseca, Luis Graca
OBJECTIVES: To investigate whether the balance of blood T follicular helper (Tfh) and Foxp3+ T follicular regulatory (Tfr) cells can inform on ectopic lymphoid neogenesis and disease activity in primary Sjögren's syndrome (SS). METHODS: We prospectively recruited 56 patients with clinical suspicion of SS, 16 of which subsequently fulfilled American European Consensus Group primary SS classification criteria and were compared with 16 patients with non-Sjögren sicca syndrome...
January 23, 2018: Arthritis & Rheumatology
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