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Follicular t helper cell

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https://www.readbyqxmd.com/read/29652652/circulating-follicular-helper-t-cells-cd4-cxcr5-icos-decrease-in-patients-with-rheumatoid-arthritis-treated-with-abatacept
#1
Silvia Piantoni, Francesca Regola, Mirko Scarsi, Angela Tincani, Paolo Airò
No abstract text is available yet for this article.
April 13, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29626573/correlation-of-allergen-specific-t-follicular-helper-cells-with-specific-ige-and-efficacy-of-allergen-immunotherapy
#2
Yin Yao, Cai-Ling Chen, Nan Wang, Zhi-Chao Wang, Jin Ma, Rong-Fei Zhu, Xiao-Yan Xu, Peng-Cheng Zhou, Di Yu, Zheng Liu
Allergen-specific IL-4+ Tfh cells may contribute to allergen-specific IgE production and correlate with clinical efficacy of AIT in AR patients, which may be a promising therapeutic target and biomarker for AIT in AR.
April 4, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29626172/-that-s-not-helping-t-follicular-helper-cells-drive-skin-fibrosis
#3
Rachael A Clark
T follicular helper-like cells and IL-21 are drivers of skin fibrosis in systemic sclerosis.
April 6, 2018: Science Immunology
https://www.readbyqxmd.com/read/29626170/the-receptor-repertoire-and-functional-profile-of-follicular-t-cells-in-hiv-infected-lymph-nodes
#4
Ben S Wendel, Daniel Del Alcazar, Chenfeng He, Perla M Del Río-Estrada, Benjamas Aiamkitsumrit, Yuria Ablanedo-Terrazas, Stefany M Hernandez, Ke-Yue Ma, Michael R Betts, Laura Pulido, Jun Huang, Phyllis A Gimotty, Gustavo Reyes-Terán, Ning Jiang, Laura F Su
Follicular helper CD4+ T cells (TFH ) play an integral role in promoting B cell differentiation and affinity maturation. Whereas TFH cell frequencies are increased in lymph nodes (LNs) from individuals infected with HIV, humoral immunity remains impaired during chronic HIV infection. Whether HIV inhibits TFH responses in LNs remains unclear. Advances in this area have been limited by the difficulty of accessing human lymphoid tissues. Here, we combined high-dimensional mass cytometry with T cell receptor repertoire sequencing to interrogate the composition of TFH cells in primary human LNs...
April 6, 2018: Science Immunology
https://www.readbyqxmd.com/read/29617174/prolonged-follicular-helper-t-cell-responses-in-me7-scrapie-infected-mice
#5
Soochan Kim, Sinsuk Han, Taehyun Kim, Jeehoon Nam, Yong-Sun Kim, Eun-Kyoung Choi, Mi-Yeon Kim
We previously reported that mice intracerebrally inoculated with the mouse-adapted scrapie strain ME7 have markedly diminished T zones in the spleen due to the decreased expression of CCL19 and CCL21. In addition, follicular dendritic cell networks in germinal centers were larger in ME7-infected spleens compared to uninfected spleens. As an extension of that study, we set out to determine how ME7 infection affects spleen structure and follicular helper T (Tfh) cell responses in mice. For this study, mice were intraperitoneally inoculated with brain homogenate of the ME7 inoculum and spleens were analyzed 50, 130, and 200 days after inoculation and compared with those from uninfected mice...
April 4, 2018: Prion
https://www.readbyqxmd.com/read/29616025/differences-between-pediatric-and-adult-t-cell-responses-to-in-vitro-staphylococcal-enterotoxin-b-stimulation
#6
Mark E Rudolph, Monica A McArthur, Robin S Barnes, Laurence S Magder, Wilbur H Chen, Marcelo B Sztein
Toxic shock syndrome (TSS) is capable of inducing life-threatening fever, rash, and systemic organ failure, though the specific mechanisms behind these symptoms remain poorly understood. Staphylococcal enterotoxin B (SEB) and other superantigens have shown to be important factors in TSS, capable of promoting cross-linking between T cell receptors and major histocompatibility complexes which results in overwhelming T cell activation, proliferation, and cytokine production. The resulting proinflammatory cytokine cascade, often referred to as the "cytokine storm," seems to be critical to the development of disease...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29616024/simian-immunodeficiency-virus-siv-specific-chimeric-antigen-receptor-t-cells-engineered-to-target-b-cell-follicles-and-suppress-siv-replication
#7
Kumudhini Preethi Haran, Agnes Hajduczki, Mary S Pampusch, Gwantwa Mwakalundwa, Diego A Vargas-Inchaustegui, Eva G Rakasz, Elizabeth Connick, Edward A Berger, Pamela J Skinner
There is a need to develop improved methods to treat and potentially cure HIV infection. During chronic HIV infection, replication is concentrated within T follicular helper cells (Tfh) located within B cell follicles, where low levels of virus-specific CTL permit ongoing viral replication. We previously showed that elevated levels of simian immunodeficiency virus (SIV)-specific CTL in B cell follicles are linked to both decreased levels of viral replication in follicles and decreased plasma viral loads. These findings provide the rationale to develop a strategy for targeting follicular viral-producing (Tfh) cells using antiviral chimeric antigen receptor (CAR) T cells co-expressing the follicular homing chemokine receptor CXCR5...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29614339/key-gene-co-expression-modules-and-functional-pathways-involved-in-the-pathogenesis-of-graves-disease
#8
Xiaoqing Shao, Bin Wang, Kaida Mu, Ling Li, Qian Li, Weiwei He, Qiuming Yao, Xi Jia, Jin-An Zhang
Graves' disease (GD) is a common autoimmune thyroid disease characterized by positive thyroid stimulating hormone receptor antibody. To better understand its molecular pathogenesis, we adopted the weighted gene co-expression network analysis to reveal co-expression modules of key genes involved in the pathogenesis of GD, protein-protein interaction network analysis to identify the hub genes related to GD development and functional analyses to explore their possible functions. Our results showed that 1) a total of 2667 differentially expressed genes in our microarray study and 16 different gene co-expression modules were associated with GD, and 2) the most significant module was associated with the percentage of macrophages, T follicular helper cells and CD4+ memory T cells and mainly enriched in immune regulation and immune response...
March 31, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29610141/altered-ratio-of-t-follicular-helper-cells-to-t-follicular-regulatory-cells-correlates-with-autoreactive-antibody-response-in-simian-immunodeficiency-virus-infected-rhesus-macaques
#9
Wenjin Fan, Andrew James Demers, Yanmin Wan, Qingsheng Li
Individuals with chronic HIV-1 infection have an increased prevalence of autoreactive Abs. Many of the isolated HIV broadly neutralizing Abs from these individuals are also autoreactive. However, the underlying mechanism(s) that produce these autoreactive broadly neutralizing Abs remains largely unknown. The highly regulated coordination among B cells, T follicular helper (TFH ) cells, and T follicular regulatory (TFR ) cells in germinal centers (GCs) of peripheral lymphatic tissues (LTs) is essential for defense against pathogens while also restricting autoreactive responses...
April 2, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29595664/roles-of-t-follicular-helper-cells-in-the-pathogenesis-of-adenoidal-hypertrophy-combined-with-secretory-otitis-media
#10
Chunyan Feng, Qicheng Zhang, Guangquan Zhou, Jing Zhang, Yanshu Zhang
The aim of this study was to investigate the roles of T follicular helper (Tfh) cells in secretory otitis media (SOM) combined with adenoidal hypertrophy (AH).Patients with AH or AH combined with SOM admitted to the Yancheng No. 1 People's Hospital from December 2012 to December 2014 were included. Fourteen age-matched healthy individuals received physical examinations in the hospital served as control. The venous Tfh was determined using flow cytometry, and CD3 + CD4 + CXCR5 + T lymphocytes were defined as Tfh cells...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29593732/a-distinct-t-follicular-helper-cell-subset-infiltrates-the-brain-in-murine-neuropsychiatric-lupus
#11
Shweta Jain, Ariel Stock, Fernando Macian, Chaim Putterman
Neuropsychiatric symptoms in systemic lupus erythematosus (SLE) are not uncommon, yet the mechanisms underlying disease initiation and progression in the brain are incompletely understood. Although the role of T cells in other lupus target organs such as the kidney is well defined, which T cells contribute to the pathogenesis of neuropsychiatric SLE is not known. The present study was aimed at characterizing the CD4 T cell populations that are present in the choroid plexus (CP) of MRL/MpJ-fas lpr mice, the primary site of brain infiltration in this classic lupus mouse model which exhibits a prominent neurobehavioral phenotype...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29588118/monitoring-the-efficacy-of-infant-hepatitis-b-vaccination-and-revaccination-in-0-to-8-year-old-children-protective-anti-hbs-levels-and-cellular-immune-responses
#12
Xuefen Li, Yumiao Xu, Yuejiao Dong, Xianzhi Yang, Bo Ye, Yiyin Wang, Yu Chen
Vaccination against hepatitis B virus (HBV) is recommended worldwide. The aim of this study was to assess the efficacy of infant hepatitis B vaccination and revaccination in 0- to 8-year-old children in the context of protective anti-HBs levels and cellular immune responses. Using a random questionnaire survey, 1695 pre-school children were recruited as research subjects during January 2015 to June 2017. Blood samples were obtained to measure HBV serological markers as well as peripheral immunocytes. The children were divided into non-, low- and hyper- responsive groups (NR, LR, and HR) based on the vaccination efficacy...
March 24, 2018: Vaccine
https://www.readbyqxmd.com/read/29581356/icos-signaling-controls-induction-and-maintenance-of-collagen-induced-arthritis
#13
Vincent Panneton, Sahar Bagherzadeh Yazdchi, Mariko Witalis, Jinsam Chang, Woong-Kyung Suh
ICOS is a key costimulatory receptor facilitating differentiation and function of follicular helper T cells and inflammatory T cells. Rheumatoid arthritis patients were shown to have elevated levels of ICOS+ T cells in the synovial fluid, suggesting a potential role of ICOS-mediated T cell costimulation in autoimmune joint inflammation. In this study, using ICOS knockout and knockin mouse models, we found that ICOS signaling is required for the induction and maintenance of collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis...
March 26, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29581354/memory-follicular-helper-invariant-nkt-cells-recognize-lipid-antigens-on-memory-b-cells-and-elicit-antibody-recall-responses
#14
Zuolong Chen, Shasha Zhu, Lu Wang, Di Xie, Huimin Zhang, Xiang Li, Xihua Zheng, Zhiwei Du, Jie Li, Li Bai
Invariant NKT (iNKT) cells have been shown to help B cells in a cognate or noncognate manner; however, whether cognate iNKT cell help induces B cell memory responses remains controversial, and the underlying mechanisms are still unclear. In this study, we demonstrated that, in the absence of follicular helper T cells, cognate iNKT cell help could promote B cell memory responses in mice that were dependent on the formation of memory follicular helper iNKT (iNKTFH ) cells and their interactions with memory B cells in recall responses...
March 26, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29578533/microrna-663-induces-immune-dysregulation-by-inhibiting-tgf-%C3%AE-1-production-in-bone-marrow-derived-mesenchymal-stem-cells-in-patients-with-systemic-lupus-erythematosus
#15
Linyu Geng, Xiaojun Tang, Kangxing Zhou, Dandan Wang, Shiying Wang, Genhong Yao, Weiwei Chen, Xiang Gao, Wanjun Chen, Songtao Shi, Nan Shen, Xuebing Feng, Lingyun Sun
Mesenchymal stem cells (MSCs) are critical for immune regulation. Although several microRNAs (miRNAs) have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function, the roles of miRNAs in MSC dysfunction in autoimmune diseases remain unclear. Here, we show that patients with systemic lupus erythematosus (SLE) display a unique miRNA signature in bone marrow-derived MSCs (BMSCs) compared with normal controls, among which miR-663 is closely associated with SLE disease activity...
March 26, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29569714/unexpected-involvement-of-il-13-signalling-via-a-stat6-independent-mechanism-during-murine-igg2a-development-following-viral-vaccination
#16
Megat A Hamid, Ronald J Jackson, Sreeja Roy, Mayank Khanna, Charani Ranasinghe
In this study, recombinant pox viral vaccination was shown to induce highly elevated IgG2a and low IgG1 antibody expression in mice lacking IL-4 or STAT6, whilst IL-13-/- mice exhibited elevated IgG1, but very low IgG2a. These findings revealed that IL-13 and IL-4 differentially regulated antibody development. To understand this further, when STAT6-/- mice were given a vaccine co-expressing IL-13Rα2 that temporarily sequestered IL-13, significantly reduced IgG2a expression, was detected. These findings for the first time demonstrated that IL-13 regulated IgG2a differentiation utilising an alternative IL-13R signalling pathway independent of STAT6 (IL-13Rα2 pathway)...
March 23, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29563292/activation-and-induction-of-antigen-specific-t-follicular-helper-cells-t-fh-play-a-critical-role-in-laiv-induced-human-mucosal-anti-influenza-antibody-response
#17
Abdullah Aljurayyan, Suttida Puksuriwong, Muhammad Ahmed, Ravi Sharma, Madhan Krishnan, Salil Sood, Katherine Davies, Devika Rajashekar, Sam Leong, Paul S McNamara, Stephen Gordon, Qibo Zhang
There is increasing interest recently in developing intranasal vaccines against respiratory tract infections. Antibody response is critical in vaccine-induced protection and TFH is considered important in mediating antibody response. Most data supporting the role for TFH in antibody response are from animal studies, and direct evidence from humans is limited, apart from TFH -like cells in blood. We studied activation and induction of TFH and its role on anti-influenza antibody response by live-attenuated influenza vaccine(LAIV) in human nasopharynx-associated lymphoid tissue(NALT)...
March 21, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29563177/relative-contributions-of-b-cells-and-dendritic-cells-from-lupus-prone-mice-to-cd4-t-cell-polarization
#18
Seung-Chul Choi, Zhiwei Xu, Wei Li, Hong Yang, Derry C Roopenian, Herbert C Morse, Laurence Morel
Mouse models of lupus have shown that multiple immune cell types contribute to autoimmune disease. This study sought to investigate the involvement of B cells and dendritic cells in supporting the expansion of inflammatory and regulatory CD4+ T cells that are critical for lupus pathogenesis. We used lupus-prone B6.NZM2410.Sle1.Sle2.Sle3 (TC) and congenic C57BL/6J (B6) control mice to investigate how the genetic predisposition of these two cell types controls the activity of normal B6 T cells. Using an allogeneic in vitro assay, we showed that TC B1-a and conventional B cells expanded Th17 cells significantly more than their B6 counterparts...
March 21, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29559975/tank-binding-kinase-1-dependent-responses-in-health-and-autoimmunity
#19
REVIEW
Cynthia Louis, Chris Burns, Ian Wicks
The pathogenesis of autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is driven by genetic predisposition and environmental triggers that lead to dysregulated immune responses. These include the generation of pathogenic autoantibodies and aberrant production of inflammatory cytokines. Current therapies for RA and other autoimmune diseases reduce inflammation by targeting inflammatory mediators, most of which are innate response cytokines, resulting in generalized immunosuppression...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29556239/plasma-cell-differentiation-pathways-in-systemic-lupus-erythematosus
#20
REVIEW
Susan Malkiel, Ashley N Barlev, Yemil Atisha-Fregoso, Jolien Suurmond, Betty Diamond
Plasma cells (PCs) are responsible for the production of protective antibodies against infectious agents but they also produce pathogenic antibodies in autoimmune diseases, such as systemic lupus erythematosus (SLE). Traditionally, high affinity IgG autoantibodies are thought to arise through germinal center (GC) responses. However, class switching and somatic hypermutation can occur in extrafollicular (EF) locations, and this pathway has also been implicated in SLE. The pathway from which PCs originate may determine several characteristics, such as PC lifespan and sensitivity to therapeutics...
2018: Frontiers in Immunology
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