keyword
MENU ▼
Read by QxMD icon Read
search

simulation model

keyword
https://www.readbyqxmd.com/read/29458201/computer-assisted-surgery-in-acetabular-fractures-virtual-reduction-of-acetabular-fracture-using-the-first-patient-specific-biomechanical-model-simulator
#1
M Boudissa, H Oliveri, M Chabanas, J Tonetti
Preoperative planning for the management of acetabular fracture is founded on geometric models allowing virtual repositioning of the bone fragments, but not taking account of soft tissue and the realities of the surgical procedure. The present technical note reports results using the first simulator to be based on a patient-specific biomechanical model, simulating the action of forces on the fragments and also the interactions between soft issue and bone: muscles, capsules, ligaments, and bone contacts. In all 14 cases, biomechanical simulation faithfully reproduced the intraoperative behavior of the various bone fragments and reduction quality...
February 16, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29458124/tryptophan-mediated-dimerization-of-the-tssl-transmembrane-anchor-is-required-for-type-vi-secretion-system-activity
#2
Abdelrahim Zoued, Jean-Pierre Duneau, Eric Durand, Alexandre P España, Laure Journet, Françoise Guerlesquin, Eric Cascales
The Type VI secretion system (T6SS) is a multiprotein complex used by bacteria to deliver effectors into target cells. The T6SS comprises a bacteriophage-like contractile tail structure anchored to the cell envelope by a membrane complex constituted of the TssJ outer membrane lipoprotein and the TssL and TssM inner membrane proteins. TssJ establishes contact with the periplasmic domain of TssM whereas the transmembrane segments of TssM and its cytoplasmic domain interact with TssL. TssL protrudes in the cytoplasm but is anchored by a C-terminal transmembrane helix (TMH)...
February 16, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29458110/investigation-of-adhesive-interactions-in-the-specific-targeting-of-triptorelin-conjugated-peg-coated-magnetite-nanoparticles-to-breast-cancer-cells
#3
Jingjie Hu, Sina Youssefian, John Obayemi, Karen Malatesta, Nima Rahbar, Winston Soboyejo
The understanding of adhesive interaction at the nanoscale between functionalized nanoparticles and biological cells is of great importance to develop effective theranostic nanocarriers for targeted cancer therapy. Here, we report a combination of experimental and computational approaches to evaluate the adhesion between Triptorelin (a Luteinizing Hormone-Releasing Hormone (LHRH) agonist)-conjugated poly-(ethylene glycol) (PEG)-coated magnetite nanoparticles (Triptorelin-MNPs) and breast cells. The adhesion forces between Triptorelin-MNPs and normal/cancerous breast cells are obtained using atomic force microscopy...
February 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29458035/lectin-carbohydrate-complex-evaluation-by-chemiluminescence
#4
Luiza Rayanna Amorim de Lima, Lúcia Patrícia Bezerra Gomes da Silva, Sinara Mônica Vitalino de Almeida, Thiago Barbosa Cahú, Eduardo Isidoro Carneiro Beltrão, Luiz Bezerra de Carvalho Júnior
In order to characterize the affinity between specific carbohydrate-binding proteins such as lectins, a model is proposed to study these interactions using a polysaccharide membrane to simulate such adsorption. Here, lectin-carbohydrate interactions were chemiluminescently investigated using lectins conjugated to acridinium ester (AE) and polysaccharides composed of their respective specific carbohydrates. The lectin-AE conjugates were incubated with discs (0.0314-0.6358 cm2 ) of phytagel, chitosan and carrageenan...
February 16, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29457969/an-evaluation-of-the-operational-model-when-applied-to-quantify-functional-selectivity
#5
Xiao Zhu, David B Finlay, Michelle Glass, Stephen B Duffull
BACKGROUND AND PURPOSE: Functional selectivity describes the ability of ligands to differentially regulate multiple signalling pathways when coupled to a single receptor and the operational model is commonly used to analyse these data. Here, we assess the mathematical properties of the operational model and evaluate the impact of fixing parameters on model performance. EXPERIMENTAL APPROACH: The operational model was evaluated using both a mathematical identifiability analysis and simulation...
February 19, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29457906/optimized-phenotypic-biomarker-discovery-and-confounder-elimination-via-covariate-adjusted-projection-to-latent-structures-from-metabolic-spectroscopy-data
#6
Joram M Posma, Isabel Garcia-Perez, Timothy M D Ebbels, John C Lindon, Jeremiah Stamler, Paul Elliott, Elaine Holmes, Jeremy K Nicholson
Metabolism is altered by genetics, diet, disease status, environment and many other factors. Modelling either one of these is often done without considering the effects of the other covariates. Attributing differences in metabolic profile to one of these factors needs to be done while controlling for the metabolic influence of the rest. We describe here a data analysis framework and novel confounder-adjustment algorithm for multivariate analysis of metabolic profiling data. Using simulated data we show that similar numbers of true associations and significantly less false positives are found compared to other commonly used methods...
February 19, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29457809/domain-size-polydispersity-effects-on-the-structural-and-dynamical-properties-in-lipid-monolayers-with-phase-coexistence
#7
Elena Rufeil-Fiori, Adolfo J Banchio
In lipid monolayers with phase coexistence, domains of the liquid-condensed phase always present size polydispersity. However, very few theoretical works consider size distribution effects on the monolayer properties. Because of the difference in surface densities, domains have excess dipolar density with respect to the surrounding liquid expanded phase, originating a dipolar inter-domain interaction. This interaction depends on the domain area, and hence the presence of a domain size distribution is associated with interaction polydispersity...
February 19, 2018: Soft Matter
https://www.readbyqxmd.com/read/29457758/appraising-cervical-mucus-a-new-approach-to-evaluating-contraceptives
#8
Leo Han, Emily Padua, Alison Edelman, Jeffrey T Jensen
PURPOSE: Timing of sample collection represents a major source of variability in studies evaluating the effects of administered agents on cervical mucus in naturally-cycling women. We sought to create and validate an artificial model of the cervical mucus cycle using exogenous E2 and P4 replacement in ovarian suppressed women. MATERIALS AND METHODS: We conducted a prospective experiment (clinicaltrials.gov, NCT02969590) examining cervical mucus changes in six women during natural and artificial menstrual cycles [leuprolide acetate, estradiol transdermal patch (0...
February 19, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29457682/predictive-models-in-ecotoxicology-bridging-the-gap-between-scientific-progress-and-regulatory-applicability-foreword
#9
Andreas Focks, Francesca Grisoni, Alpar Barsi, Marco Vighi
In the last decades, modelling approaches in the context of environmental risk assessment for chemicals have been under the spotlight of researchers in academia, regulatory bodies and industry. This is because mathematical and simulation models allow to gain deeper mechanistic understanding of fate and effect processes of organic contaminants in the environment. In addition, models make it possible to predict the toxic effects of compounds along with other relevant properties, such as biodegradability, uptake and bioaccumulation...
February 19, 2018: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/29457655/importance-of-growth-rate-on-hg-and-pcb-bioaccumulation-in-fish
#10
Jiajia Li, G Douglas Haffner, Gordon Paterson, David M Walters, Michael D Burtnyk, Ken G Drouillard
To evaluate the effect of fish growth on mercury (Hg) and polychlorinated biphenyls (PCBs) bioaccumulation, a non-steady state toxicokinetic model, combined with a Wisconsin bioenergetics model, was developed to simulate Hg and PCB bioaccumulation in Bluegill (Lepomis macrochirus). The model was validated by comparing observed versus predicted Hg and PCB 180 concentrations across 5 age classes from five different waterbodies across North America. The non-steady state model generated accurate predictions for Hg and PCB bioaccumulation in three of five waterbodies: Apsey, Sharbot and Stonelick Lake...
February 19, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29457631/non-invasive-genetic-censusing-and-monitoring-of-primate-populations
#11
REVIEW
Mimi Arandjelovic, Linda Vigilant
Knowing the density or abundance of primate populations is essential for their conservation management and contextualizing socio-demographic and behavioral observations. When direct counts of animals are not possible, genetic analysis of non-invasive samples collected from wildlife populations allows estimates of population size with higher accuracy and precision than is possible using indirect signs. Furthermore, in contrast to traditional indirect survey methods, prolonged or periodic genetic sampling across months or years enables inference of group membership, movement, dynamics, and some kin relationships...
February 19, 2018: American Journal of Primatology
https://www.readbyqxmd.com/read/29457371/validation-of-a-blood-marker-for-plasma-volume-in-endurance-athletes-during-a-live-high-train-low-altitude-training-camp
#12
Louisa M Lobigs, Laura A Garvican-Lewis, Victor L Vuong, Nicolin Tee, Christopher J Gore, Peter Peeling, Brian Dawson, Yorck O Schumacher
Altitude is a confounding factor within the Athlete's Biological Passport (ABP) due, in part, to the plasma volume (PV) response to hypoxia. Here, a newly developed PV blood test is applied to assess the possible efficacy of reducing the influence of PV on the volumetric ABP markers; hemoglobin concentration ([Hb]) and the OFF-score. Endurance athletes (n=34) completed a 21 night simulated live high: train low protocol (14h.d-1 at 3000m). Bloods were collected twice pre-altitude, at days 3, 8 and 15 at altitude and 1, 7, 21 and 42 days post-altitude...
February 19, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29457313/modeling-the-hematocrit-distribution-in-microcirculatory-networks-a-quantitative-evaluation-of-a-phase-separation-model
#13
Peter M Rasmussen, Timothy W Secomb, Axel R Pries
OBJECTIVE: Theoretical models are essential tools for studying microcirculatory function. Recently, the validity of a well-established phase separation model was questioned and it was claimed that it produces problematically low hematocrit predictions and lack of red cells in small diameter vessels. We conducted a quantitative evaluation of this phase separation model to establish common ground for future research. METHODS: Model predictions were validated against a comprehensive data base with measurements from four mesenteric networks...
February 19, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29457181/ab-initio-kinetics-of-the-hoso-2-3-o-2-%C3%A2-so-3-ho-2-reaction
#14
Tam V-T Mai, Minh V Duong, Hieu T Nguyen, Lam K Huynh
The detailed kinetic mechanism of the HOSO2 +3 O2 reaction, which plays a pivotal role in the atmospheric oxidation of SO2 , was investigated using accurate electronic structure calculations and novel statistical thermodynamic/kinetic models. Explored using the accurate composite method W1U, the detailed potential energy surface (PES) revealed that the addition of O2 to a HOSO2 radical to form the adduct (HOSO4 ) proceeds via a transition state with a slightly positive barrier (i.e., 0.7 kcal mol-1 at 0 K)...
February 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29456922/propensity-scores-in-pharmacoepidemiology-beyond-the-horizon
#15
John W Jackson, Ian Schmid, Elizabeth A Stuart
Purpose of review: Propensity score methods have become commonplace in pharmacoepidemiology over the past decade. Their adoption has confronted formidable obstacles that arise from pharmacoepidemiology's reliance on large healthcare databases of considerable heterogeneity and complexity. These include identifying clinically meaningful samples, defining treatment comparisons, and measuring covariates in ways that respect sound epidemiologic study design. Additional complexities involve correctly modeling treatment decisions in the face of variation in healthcare practice, and dealing with missing information and unmeasured confounding...
December 2017: Current Epidemiology Reports
https://www.readbyqxmd.com/read/29456913/investigating-the-7-year-cost-effectiveness-of-single-level-cervical-disc-replacement-compared-to-anterior-cervical-discectomy-and-fusion
#16
Steven J McAnany, Robert K Merrill, Samuel C Overley, Jun S Kim, Robert L Brochin, Sheeraz A Qureshi
Study Design: Cost-effectiveness analysis. Objectives: To determine the 7-year cost-effectiveness of cervical disc replacement (CDR) and anterior cervical discectomy and fusion (ACDF). Methods: We analyzed 7-year Short Form-36 Health Survey data collected from the Prestige Cervical Disc investigational device exemption study (IDE). The SF-6D algorithm was used to convert this data into health state utilities. Costs were calculated from the payer perspective, and quality adjusted life years (QALYs) were used to represent effectiveness...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456895/calibration-adjustments-to-address-bias-in-mortality-analyses-due-to-informative-sampling-a-census-linked-survey-analysis-in-switzerland
#17
André Moser, Matthias Bopp, Marcel Zwahlen
Background: Sampling bias, like survey participants' nonresponse, needs to be adequately addressed in the analysis of sampling designs. Often survey weights will be calibrated on specific covariates related to the probability of selection and nonresponse to get representative population estimates. However, such calibrated survey (CS) weights are usually constructed for cross-sectional results, but not for longitudinal analyses. For example, when the outcome of interest is time to death, and sampling selection is related to time to death and censoring, sampling is informative...
2018: PeerJ
https://www.readbyqxmd.com/read/29456831/early-afterdepolarisation-tendency-as-a-simulated-pro-arrhythmic-risk-indicator
#18
Beth McMillan, David J Gavaghan, Gary R Mirams
Drug-induced Torsades de Pointes (TdP) arrhythmia is of major interest in predictive toxicology. Drugs which cause TdP block the hERG cardiac potassium channel. However, not all drugs that block hERG cause TdP. As such, further understanding of the mechanistic route to TdP is needed. Early afterdepolarisations (EADs) are a cell-level phenomenon in which the membrane of a cardiac cell depolarises a second time before repolarisation, and EADs are seen in hearts during TdP. Therefore, we propose a method of predicting TdP using induced EADs combined with multiple ion channel block in simulations using biophysically-based mathematical models of human ventricular cell electrophysiology...
November 1, 2017: Toxicology Research
https://www.readbyqxmd.com/read/29456751/cannulated-screw-versus-kirschner-wire-fixation-for-milch-ii-lateral-condyle-fractures-in-a-paediatric-sawbone-model-a-biomechanical-comparison
#19
D Franks, J Shatrov, M Symes, D G Little, T L Cheng
Purpose: Lateral condyle fractures of the humerus are common in the paediatric population, accounting for up to 20% of elbow fractures. Traditional management involves internal fixation with Kirschner (K)-wires, however, this has been associated with complications and insufficiently rigid fixation. Recently, cannulated screws have been proposed as a more stable method of fixation. While cannulated screws have been thought to allow earlier range of movement and shorten time to union, data regarding the biomechanical performance and optimal screw placement is scarce...
February 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29456508/the-molecular-determinants-of-small-molecule-ligand-binding-at-p2x-receptors
#20
Gaia Pasqualetto, Andrea Brancale, Mark T Young
P2X receptors are trimeric eukaryotic ATP-gated cation channels. Extracellular ATP-their physiological ligand-is released as a neurotransmitter and in conditions of cell damage such as inflammation, and substantial evidence implicates P2X receptors in diseases including neuropathic pain, cancer, and arthritis. In 2009, the first P2X crystal structure, Danio rerio P2X4 in the apo - state, was published, and this was followed in 2012 by the ATP-bound structure. These structures transformed our understanding of the conformational changes induced by ATP binding and the mechanism of ligand specificity, and enabled homology modeling of mammalian P2X receptors for ligand docking and rational design of receptor modulators...
2018: Frontiers in Pharmacology
keyword
keyword
39233
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"