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https://www.readbyqxmd.com/read/28532140/effective-treatment-of-cervical-lymph-node-metastasis-of-breast-cancer-by-low-voltage-high-frequency-electrochemotherapy
#1
Bahram Mofid, Zeinab Shankayi, Kambiz Novin, Sadegh Dehghani, Morteza Shankayi, Hamidreza Haghighatkhah, S Mohammad Firoozabadi
Electrochemotherapy (ECT) is a new local treatment method for solid and superficial tumors. During this new technique, patients experience an unpleasant sensation and slight edema. Most unpleasant and painful is mainly attributed to muscle contractions provoked by high amplitude and low repetition frequency pulses. Recently, we showed that electrochemotherapy using low voltage and higher repetition frequency (LVHF ECT) is an effective tool for inhibiting tumor growth and inducing cell permeabilization. Low voltage high-frequency electrochemotherapy was developed and optimized in vitro and in vivo which and can be used in the clinic...
April 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28525197/-treatment-resistant-depression-actuality-and-perspectives-in-2017
#2
REVIEW
N Lucas, P Hubain, G Loas, F Jurysta
Major depressive disorder (MDD) affects 3 to 17 % of adults. 15 to 30 % of patients with MDD suffer from treatment resistant depression (TRD). No international consensus defines TRD. The most common definition is " MDD that is not enough improved after two successive and different classes of antidepressant treatments in appropriate dose and duration ". The appropriate dose corresponds to maximal dose accepted by scientific reports and clinical recommendations, while the appropriate duration is around 6 weeks...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28521271/the-association-of-electroconvulsive-therapy-to-pharmacological-treatment-and-its-influence-on-cytokines
#3
Thiago Fernando Vasconcelos Freire, Neusa Sica da Rocha, Marcelo Pio de Almeida Fleck
INTRODUCTION: A growing body of evidence shows that disturbances in the immune system are involved in the pathogenesis of depression. Although the immune-modulating effects of antidepressants have been described, few studies have addressed the functioning of the immune system in relation to electroconvulsive therapy (ECT). This study aims to investigate if the addition of ECT to pharmacotherapy is associated with changes in cytokine levels. METHODS: Adult inpatients were invited to participate in this study on admission to a psychiatric unit...
May 9, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28514646/heparin-removal-by-ecteola-cellulose-pre-treatment-enables-the-use-of-plasma-samples-for-accurate-measurement-of-anti-yellow-fever-virus-neutralizing-antibodies
#4
Ana Carolina Campi-Azevedo, Vanessa Peruhype-Magalhães, Jordana Grazziela Coelho-Dos-Reis, Christiane Costa-Pereira, Anna Yoshida Yamamura, Sheila Maria Barbosa de Lima, Marisol Simões, Fernanda Freire Campos Nunes, Aline de Castro Zacche Tonini, Elenice Moreira Lemos, Ricardo Cristiano Brum, Tatiana Guimarães de Noronha, Marcos da Silva Freire, Maria de Lourdes Sousa Maia, Luiz Antônio Bastos Camacho, Maria Rios, Caren Chancey, Alessandro Romano, Carla Magda Domingues, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho
Technological innovations in vaccinology have recently contributed to bring about novel insights for the vaccine-induced immune response. While the current protocols that use peripheral blood samples may provide abundant data, a range of distinct components of whole blood samples are required and the different anticoagulant systems employed may impair some properties of the biological sample and interfere with functional assays. Although the interference of heparin in functional assays for viral neutralizing antibodies such as the functional plaque-reduction neutralization test (PRNT), considered the gold-standard method to assess and monitor the protective immunity induced by the Yellow fever virus (YFV) vaccine, has been well characterized, the development of pre-analytical treatments is still required for the establishment of optimized protocols...
May 14, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28509598/elevated-dopamine-d1-receptor-availability-in-striatum-of-g%C3%A3-ttingen-minipigs-after-electroconvulsive-therapy
#5
Anne M Landau, Aage Ko Alstrup, Helene Audrain, Steen Jakobsen, Mette Simonsen, Arne Møller, Poul Videbech, Gregers Wegener, Albert Gjedde, Doris J Doudet
Electroconvulsive therapy (ECT), a direct form of brain stimulation, is an effective antidepressant. We hypothesized that the beneficial effects of ECT are mediated by increased dopaminergic neurotransmission, in which the baseline activity of D1 receptors may predict the response to ECT. We established a novel model of brain stimulation in Göttingen minipigs based on the protocol of ECT applied in humans. With positron emission tomography (PET), we determined a measure of dopaminergic neurotransmission with the dopamine D1 receptor antagonist [(11)C]SCH23390...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28503107/the-role-of-electroconvulsive-therapy-ect-in-bipolar-disorder-effectiveness-in-522-patients-with-bipolar-depression-mixed-state-mania-and-catatonic-features
#6
Giulio Perugi, Pierpaolo Medda, Cristina Toni, Michela Giorgi Mariani, Chiara Socci, Mauro Mauri
OBJECTIVE: We evaluated the effectiveness of Electroconvulsive Therapy (ECT) in the treatment of Bipolar Disorder (BD) in a large sample of bipolar patients with drug resistant depression, mania, mixed state and catatonic features. METHOD: 522 consecutive patients with DSM-IV-TR BD were evaluated prior to and after the ECT course. Responders and nonresponders were compared in subsamples of depressed and mixed patients. Descriptive analyses were reported for patients with mania and with catatonic features...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28499572/a-national-survey-on-nursing-in-canadian-ect-departments
#7
Mark Jewell, Nicholas John Delva, Peter Graf, Peter Chan, Murray Enns, Caroline Gosselin, Ian Gilron, James Stuart Lawson, Barry Martin, Roumen Milev, Simon Patry, Maria Bonifacio
No abstract text is available yet for this article.
June 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28499278/long-non-coding-rnas-in-b-cell-malignancies-a-comprehensive-overview
#8
REVIEW
Lucia Nobili, Domenica Ronchetti, Elisa Taiana, Antonino Neri
B-cell malignancies constitute a large part of hematological neoplasias. They represent a heterogeneous group of diseases, including Hodgkin's lymphoma, most non-Hodgkin's lymphomas (NHL), some leukemias and myelomas. B-cell malignancies reflect defined stages of normal B-cell differentiation and this represents the major basis for their classification. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts longer than 200 nucleotides, for which many recent studies have demonstrated a function in regulating gene expression, cell biology and carcinogenesis...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28498040/pivotal-role-of-non-cardiomyocytes-in-electromechanical-and-therapeutic-potential-of-induced-pluripotent-stem-cell-derived-engineered-cardiac-tissue
#9
Hiroko Iseoka, Shigeru Miyagawa, Satsuki Fukushima, Atsuhiro Saito, Shigeo Masuda, Shin Yajima, Emiko Ito, Nagako Sougawa, Maki Takeda, Akima Harada, Jong-Kook Lee, Yoshiki Sawa
Although engineered cardiac tissues (ECTs) derived from induced pluripotent stem cells (iPSCs) are promising for myocardial regenerative therapy, the appropriate ratio of cardiomyocytes to non-cardiomyocytes is not fully understood. Here, we determined whether ECT-cell content is a key determinant of its structure/function, thereby affecting ECT therapeutic potential for advanced heart failure. Scaffold-free ECTs containing different ratios (25%, 50%, 70%, or 90%) of iPSC-derived cardiomyocytes were generated by magnetic-activated cell sorting using cardiac-specific markers...
May 12, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28497190/abstracts-of-the-ects-congress-2017
#10
(no author information available yet)
No abstract text is available yet for this article.
May 11, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28496402/cortico-striatal-thalamic-loop-circuits-of-the-orbitofrontal-cortex-promising-therapeutic-targets-in-psychiatric-illness
#11
REVIEW
Peter Fettes, Laura Schulze, Jonathan Downar
Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex human behaviors such as evaluation, affect regulation and reward-based decision-making. Importantly, the medial and lateral OFC (mOFC and lOFC) circuits have functionally and anatomically distinct connectivity profiles which differentially contribute to the various aspects of goal-directed behavior. OFC corticostriatal circuits have been consistently implicated across a wide range of psychiatric disorders, including major depressive disorder (MDD), obsessive compulsive disorder (OCD), and substance use disorders (SUDs)...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28490767/biliverdin-reductase-inhibitors-did-not-improve-severe-unconjugated-hyperbilirubinemia-in-vivo
#12
Remco van Dijk, Sem J Aronson, Dirk R de Waart, Stan F van de Graaf, Suzanne Duijst, Jurgen Seppen, Ronald Oude Elferink, Ulrich Beuers, Piter J Bosma
We aimed to identify potent biliverdin reductase (BVRA) inhibitors as a novel concept for the treatment of severe unconjugated hyperbilirubinemia. 1280 FDA-approved compounds were screened in vitro for their ability to inhibit human and rat BVRA activity and 26 compounds were identified as BVRA inhibitors. Montelukast and Disulfiram were selected as potentially clinically applicable drugs and tested to reduce serum unconjugated bilirubin (UCB) levels in the Ugt1a1-deficient rat, a model for chronic unconjugated hyperbilirubinemia...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28485819/an-open-circuit-voltage-and-power-conversion-efficiency-study-of-fullerene-ternary-organic-solar-cells-based-on-oligomer-oligomer-and-oligomer-polymer
#13
Guichuan Zhang, Cheng Zhou, Chen Sun, Xiaoe Jia, Baomin Xu, Lei Ying, Fei Huang, Yong Cao
Variations in the open-circuit voltage (Voc ) of ternary organic solar cells are systematically investigated. The initial study of these devices consists of two electron-donating oligomers, S2 (two units) and S7 (seven units), and the electron-accepting [6,6]-phenyl C71 butyric acid methyl ester (PC71 BM) and reveals that the Voc is continuously tunable due to the changing energy of the charge transfer state (Ect ) of the active layers. Further investigation suggests that Voc is also continuously tunable upon change in Ect in a ternary blend system that consists of S2 and its corresponding polymer (P11):PC71 BM...
May 9, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28471773/effect-of-atropine-premedication-on-cardiac-autonomic-function-during-electroconvulsive-therapy-a-randomized-crossover-study
#14
Tanmay Jadhav, Kamath Sriganesh, Jagadisha Thirthalli, K R Madhusudan Reddy, Sudhir Venkataramaiah, Mariamma Philip, Channaveerachari Naveen Kumar, Shyam Sundar Armugham
OBJECTIVES: Electroconvulsive therapy (ECT) results in significant cardiovascular changes. The acute cardiac autonomic changes during ECT remain unexplored. The primary objective of this study was to compare autonomic dysfunction with and without atropine premedication during ECT and secondarily to evaluate dysautonomia across psychiatric diagnoses before and after ECT. METHODS: In this crossover study, 41 psychiatric patients were monitored during 82 ECT sessions...
May 2, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28471772/reexamining-the-role-of-electroconvulsive-therapy-in-anorexia-nervosa-in-adolescents
#15
Laura Andersen, Christina LaRosa, Daniel E Gih
Electroconvulsive therapy (ECT) is rarely, if ever, considered for the treatment of severe anorexia nervosa (AN) or other eating disorders comorbid with an affective illness. Mood disorders are common in these patients, and psychotropic medications, although frequently used, have limited evidence of benefit in AN or copresenting depressive symptoms. Even when the illness is life threatening, ECT as a treatment may be overlooked. We present a case of an adolescent girl with severe AN and comorbid major depressive disorder with suicidality...
May 2, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28471771/rapid-response-to-electroconvulsive-therapy-a-case-report-and-literature-review
#16
Duy V Tran, Justin P Meyer, Kate G Farber, Xi Richard Chen, Blake D Rosenthal, Charles H Kellner
Although a typical course of electroconvulsive therapy (ECT) consists of 6 to 12 treatments, remission of depression has rarely been reported after a single treatment. We present the case of a 25-year-old woman hospitalized for a major depressive episode and suicidality, in the context of bipolar 1 disorder, whose symptoms fully remitted with 1 ECT. We also review the literature on rapid response to ECT.
May 3, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28465691/effects-of-macromolecular-crowding-on-human-adipose-stem-cell-culture-in-fetal-bovine-serum-human-serum-and-defined-xeno-free-serum-free-conditions
#17
Mimmi Patrikoski, Michelle Hui Ching Lee, Laura Mäkinen, Xiu Min Ang, Bettina Mannerström, Michael Raghunath, Susanna Miettinen
Microenvironment plays an important role for stem cell proliferation and differentiation. Macromolecular crowding (MMC) was recently shown to assist stem cells in forming their own matrix microenvironment in vitro. The ability of MMC to support adipose stem cell (ASC) proliferation, metabolism, and multilineage differentiation was studied under different conditions: fetal bovine serum- (FBS-) and human serum- (HS-) based media and xeno- and serum-free (XF/SF) media. Furthermore, the immunophenotype of ASCs under MMC was evaluated...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28465470/subclinical-involvement-of-the-liver-is-associated-with-prognosis-in-treatment-na%C3%A3-ve-cancer-patients
#18
Noemi Pavo, Markus Raderer, Georg Goliasch, Raphael Wurm, Guido Strunk, Anna Cho, Johannes F Novak, Heinz Gisslinger, Günther G Steger, Michael Hejna, Wolfgang Köstler, Sabine Zöchbauer-Müller, Christine Marosi, Gabriela Kornek, Leo Auerbach, Sven Thorben Schneider, Bernhard Parschalk, Werner Scheithauer, Robert Pirker, Barbara Kiesewetter, Richard Pacher, Christoph Zielinski, Martin Hülsmann
BACKGROUND: Routinely tested liver biomarkers as alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), butyryl-cholinesterase (BChE), albumin and bilirubin are altered in distinct malignancies and hepatic metastases. This study aimed to investigate whether all liver parameters have the ability to predict long-term mortality in treatment naïve cancer patients but without a malignant hepatic involvement. METHODS: We prospectively enrolled 555 consecutive patients with primary diagnosis of cancer without prior anticancer therapy...
April 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28463343/biological-treatment-of-acute-agitation-or-aggression-with-schizophrenia-or-bipolar-disorder-in-the-inpatient-setting
#19
Christoph U Correll, Xin Yu, Yutao Xiang, John M Kane, Prakash Masand
BACKGROUND: Schizophrenia and bipolar disorders are chronic illnesses that commonly present with symptoms of acute agitation and aggression. These symptoms must be managed rapidly to prevent potential harm to the patient and others, including their caregivers, peers, and health care workers. A number of treatment options are available to clinicians to manage acute agitation and aggression, including non-pharmacologic behavioral and environmental de-escalation strategies, as well as biological treatment options such as pharmacologic agents and electroconvulsive therapy...
May 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28462732/anaesthesia-for-electroconvulsive-therapy-new-tricks-for-old-drugs-a-systematic-review
#20
Tobias Kvist Stripp, Martin Balslev Jorgensen, Niels Vidiendal Olsen
OBJECTIVE: The objective of this review is to investigate existing literature in order to delineate whether the use of anaesthesia and timing of seizure induction in a new and optimised way may improve the efficacy of electroconvulsive therapy (ECT). METHODS: PubMed/MEDLINE was searched for existing literature, last search on 24 June 2015. Relevant clinical studies on human subjects involving choice of anaesthetic, ventilation and bispectral index (BIS) monitoring in the ECT setting were considered...
May 2, 2017: Acta Neuropsychiatrica
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