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https://www.readbyqxmd.com/read/29656263/early-improvement-as-a-predictor-of-final-remission-in-major-depressive-disorder-new-insights-in-electroconvulsive-therapy
#1
Erika Martínez-Amorós, Ximena Goldberg, Verònica Gálvez, Aida de Arriba-Arnau, Virginia Soria, José M Menchón, Diego J Palao, Mikel Urretavizcaya, Narcís Cardoner
BACKGROUND: Early improvement to antidepressant drugs predicts remission, but the predictive value of early improvement to electroconvulsive therapy (ECT) is still unclear. The main aim of this study was to determine the optimal definition of early improvement in the treatment of major depressive disorder (MDD) with ECT, by analyzing its value as a predictor of remission. METHODS: A naturalistic study was conducted in 87 adult MDD patients treated with acute ECT...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29652671/exploring-proximity-e%C3%AF-ects-and-large-depth-of-%C3%AF-eld-in-helium-ion-beam-lithography-large-area-dense-patterns-and-tilted-surface-exposure
#2
Ranveig Flatabø, Akshay Agarwal, Richard Hobbs, Martin Møeller Greve, Bodil Holst, Karl K Berggren
Helium ion beam lithography (HIL) is an emerging nanofabrication technique. It benefits from a reduced interaction volume compared to that of an electron beam of similar energy, and hence reduced long-range scattering (proximity effect), higher resist sensitivity and potentially higher resolution. Furthermore, the small angular spread of the helium ion beam gives rise to a large depth of field. This should enable patterning on tilted and curved surfaces without the need of any additional adjustments, such as laser-auto focus...
April 13, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29650412/theoretical-considerations-for-muscle-energy-savings-during-distance-running
#3
Jared R Fletcher, Brian R MacIntosh
We have recently demonstrated that the triceps surae muscles energy cost (ECTS ) represents a substantial portion of the total metabolic cost of running (Erun ). Therefore, it seems relevant to evaluate the factors which dictate ECTS , namely the amount and velocity of shortening, since it is likely these factors will dictate Erun . Erun and triceps surae morphological and AT mechanical properties were obtained in 46 trained and elite male and female distance runners using ultrasonography and dynamometry. ECTS (J·stride-1 ) at the speed of lactate threshold (sLT) was estimated from AT force and crossbridge mechanics and energetics...
March 27, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29643069/an-m6a-yth-module-controls-developmental-timing-and-morphogenesis-in-arabidopsis
#4
Laura Arribas-Hernández, Simon Bressendorff, Mathias Henning Hansen, Christian Poulsen, Susanne Erdmann, Peter Brodersen
Methylation of N6-adenosine (m6A) in mRNA is an important post-transcriptional gene regulatory mechanism in eukaryotes. m6A provides a binding site for effector proteins ("readers") that influence pre-mRNA splicing, mRNA degradation or translational efficiency. YT521-B homology (YTH) domain proteins are important m6A readers with established functions in animals. Plants contain more YTH domain proteins than other eukaryotes, but their biological importance remains unknown. Here, we show that the cytoplasmic Arabidopsis thaliana YTH domain proteins EVOLUTIONARILY CONSERVED C-TERMINAL REGION2/3 (ECT2/3) are required for the correct timing of leaf formation and for normal leaf morphology...
April 11, 2018: Plant Cell
https://www.readbyqxmd.com/read/29643022/involuntary-and-voluntary-electroconvulsive-therapy-a-case-control-study
#5
Martha Finnegan, Stephanie O'Connor, Declan M McLoughlin
BACKGROUND: It is not known whether results of clinical research in ECT can be used to guide treatment decisions for those having involuntary ECT, who are not represented in trial populations. OBJECTIVE: We aimed to compare courses of involuntary ECT with matched voluntary ECT courses in terms of clinical and demographic factors, treatment requirements, and outcomes. METHOD: We performed a retrospective case-control study examining a five-year sample of involuntary ECT courses and an age-, gender- and time-matched voluntary ECT control sample...
April 5, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29628852/anesthetic-and-psychiatric-implications-of-accidental-awareness-under-general-anesthesia-during-electroconvulsive-therapy
#6
Hetal Acharya, Atul Gaur, Girish Kunigiri
Accidental awareness under general anesthesia (AAGA) is a well-known phenomenon. However, little literature exists in its relation to the psychiatric field, particularly within the electroconvulsive therapy (ECT) setting. This report explores the case of a 52-year-old woman that describes her own experience of AAGA during ECT. Relevant anesthetic details are also provided along with its possible implications in AAGA. The aim of this case report is to increase awareness among clinicians in regard to AAGA and its occurrence during ECT...
April 2018: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29623228/response-after-infection-associated-rise-in-clozapine-levels-in-treatment-resistant-schizoaffective-disorder
#7
Nina H Grootendorst-van Mil, Anna R M Huiskens, Sieds Dieleman, Tom K Birkenhäger
The clinical management of patients with treatment-resistant psychotic disorders is still challenging despite years of extensive research. If first-line antipsychotic treatment proves ineffective, clozapine is considered golden standard. Herein, we report on a patient with schizoaffective disorder that initially showed no response to treatment with clozapine and ECT and therefore reached a therapeutic dead end. After an unintentional exposure to supratherapeutic clozapine levels, related to a pneumonia, a significant and persistent reduction of psychotic symptoms occurred...
2018: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/29618992/fronto-temporal-connectivity-predicts-ect-outcome-in-major-depression
#8
Amber M Leaver, Benjamin Wade, Megha Vasavada, Gerhard Hellemann, Shantanu H Joshi, Randall Espinoza, Katherine L Narr
Background: Electroconvulsive therapy (ECT) is arguably the most effective available treatment for severe depression. Recent studies have used MRI data to predict clinical outcome to ECT and other antidepressant therapies. One challenge facing such studies is selecting from among the many available metrics, which characterize complementary and sometimes non-overlapping aspects of brain function and connectomics. Here, we assessed the ability of aggregated, functional MRI metrics of basal brain activity and connectivity to predict antidepressant response to ECT using machine learning...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29615675/predicting-individual-responses-to-the-electroconvulsive-therapy-with-hippocampal-subfield-volumes-in-major-depression-disorder
#9
Bo Cao, Qinghua Luo, Yixiao Fu, Lian Du, Tian Qiu, Xiangying Yang, Xiaolu Chen, Qibin Chen, Jair C Soares, Raymond Y Cho, Xiang Yang Zhang, Haitang Qiu
Electroconvulsive therapy (ECT) is one of the most effective treatments for major depression disorder (MDD). ECT can induce neurogenesis and synaptogenesis in hippocampus, which contains distinct subfields, e.g., the cornu ammonis (CA) subfields, a granule cell layer (GCL), a molecular layer (ML), and the subiculum. It is unclear which subfields are affected by ECT and whether we predict the future treatment response to ECT by using volumetric information of hippocampal subfields at baseline? In this study, 24 patients with severe MDD received the ECT and their structural brain images were acquired with magnetic resonance imaging before and after ECT...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29613943/patient-experience-of-electroconvulsive-therapy-a-retrospective-review-of-clinical-outcomes-and-satisfaction
#10
Sarah K Brown, Rachel B Nowlin, Rebecca Sartorelli, Johan Smith, Karen Johnson
OBJECTIVE: The aim of the study was to explore patient perception and perceived benefit of electroconvulsive therapy (ECT) by assessing the real-world experience of adult patients who received ECT, focusing on clinical outcomes and patient satisfaction. METHODS: This retrospective study analyzed patient self-report of depressive symptoms (Patient Health Questionnaire), perception of physical and cognitive ECT adverse effects (ECT Outcomes Survey) and satisfaction with treatment (Patient Satisfaction Survey)...
April 2, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29613942/duration-of-pupillary-unresponsiveness-to-light-a-physiological-adjunct-to-electroencephalography-and-motor-seizure-duration-monitoring-during-electroconvulsive-therapy
#11
Sudhir Venkataramaiah, Ganne S Umamaheswara Rao, Sriganesh Kamath, Tanmay Jadhav, Channaveerachari Naveen Kumar, Shyam Sundar Arumugham, Madhusudan Reddy, Mariamma Philip, Jagadisha Thirthalli
BACKGROUND: During electroconvulsive therapy (ECT) sessions, we observed that the time taken for the return of pupillary response to light (ROPL) outlasted both the electroencephalography (EEG) and the motor seizure duration after the delivery of the electrical stimulus to produce convulsions. OBJECTIVE: The objective of this study was to investigate whether ROPL can be used as a marker of cessation of seizure activity in the brain after ECT and also to study the effect of atropine premedication on seizure activity during ECT...
April 2, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29611450/elevated-serum-vascular-endothelial-growth-factor-in-treatment-resistant-schizophrenia-treated-with-electroconvulsive-therapy-positive-association-with-therapeutic-effects
#12
Wenhuan Xiao, Qiongqiong Zhan, Fei Ye, Xiaowei Tang, Jin Li, Hui Dong, Weiwei Sha, Xiaobin Zhang
OBJECTIVES: As the name implies, vascular endothelial growth factor (VEGF) enhances angiogenesis, promotes vascular permeability, and stimulates neurogenesis in the adult brain. Furthermore, animal model studies have shown that electroconvulsive therapy (ECT), which is primarily utilized in cases of treatment-resistant schizophrenia (TRS), regulates the expression of VEGF. The current study focuses largely on the effect of ECT on VEGF serum concentration, and the relationship between VEGF and therapeutic effects in patients diagnosed with TRS...
April 3, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29609474/a-comparison-between-right-unilateral-ultrabrief-electroconvulsive-therapy-and-bilateral-electroconvulsive-therapy-in-the-elderly-a-pilot-naturalistic-observational-study
#13
Shalini Narchal, Anthony Wf Harris, Bruce Allen
OBJECTIVES: To compare clinical outcomes and adverse effects between Bitemporal (BT) and Right Unilateral Ultrabrief (RUL(UB)) electroconvulsive therapy (ECT) in an elderly population. METHODS: Patients over the age of 65 years admitted to a tertiary referral hospital over a seven month period requiring ECT received RUL(UB) ECT. They were compared with those who received BT ECT over these and the preceding seven months. RESULTS: Twenty-three patients entered the study...
March 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29594252/learning-radiation-oncology-in-europe-results-of-the-estro-multidisciplinary-survey
#14
Jean-Emmanuel Bibault, Pierfrancesco Franco, Gerben R Borst, Wouter Van Elmpt, Daniela Thorwhart, Maximilian P Schmid, Kasper M A Rouschop, Mateusz Spalek, Laura Mullaney, Kathrine Røe Redalen, Ludwig Dubois, Christine Verfaillie, Jesper Grau Eriksen
Introduction: Radiotherapy education can be very different across Europe, despite the publication of the ESTRO core curricula in 2011. The purpose of the current study is to map the different RO European education systems, to report their perceived quality and to understand what could be improved to better teach RO. Methods: An online survey consisting of 30 questions was sent to RO professionals under 40 years of age via email and social media. Clinicians, radiobiologists, physicists and radiation therapists (RTTs) were invited to answer questions regarding (1) demographics data, (2) duration, (3) organization, (4) content, (5) quality and potential improvements of national education programs...
February 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29570959/galantamine-memantine-combination-for-cognitive-impairments-due-to-electroconvulsive-therapy-traumatic-brain-injury-and-neurologic-and-psychiatric-disorders-kynurenic-acid-and-mismatch-negativity-target-engagement
#15
Maju Mathew Koola
Cognitive impairments due to electroconvulsive therapy (ECT), traumatic brain injury (TBI), and neurologic and psychiatric disorders are prevalent. Cholinergic and glutamatergic pathways, α-7 nicotinic acetylcholine (α-7nACh) receptor, and N-methyl-d-aspartate (NMDA) receptor are potential pathophysiologic mechanisms in all of these conditions. Galantamine not only is an acetylcholinesterase inhibitor but has a dual mode of action as a α-7nACh receptor modulator as well. Memantine is a noncompetitive NMDA receptor antagonist...
March 1, 2018: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29560920/distinct-neural-functional-effects-of-treatments-with-selective-serotonin-reuptake-inhibitors-electroconvulsive-therapy-and-transcranial-magnetic-stimulation-and-their-relations-to-regional-brain-function-in-major-depression-a-meta-analysis
#16
David T Chau, Phoebe Fogelman, Pia Nordanskog, Wayne C Drevets, J Paul Hamilton
BACKGROUND: Functional neuroimaging studies have examined the neural substrates of treatments for major depressive disorder (MDD). Low sample size and methodological heterogeneity, however, undermine the generalizability of findings from individual studies. We conducted a meta-analysis to identify reliable neural changes resulting from different modes of treatment for MDD and compared them with each other and with reliable neural functional abnormalities observed in depressed versus control samples...
May 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29559016/differential-plastic-changes-in-synthesis-and-binding-in-the-mouse-somatostatin-system-after-electroconvulsive-stimulation
#17
Mikkel Vestergaard Olesen, Casper René Gøtzsche, Søren Hofman Christiansen, David Paul Drucker Woldbye
OBJECTIVE: Electroconvulsive therapy (ECT) is regularly used to treat patients with severe major depression, but the mechanisms underlying the beneficial effects remain uncertain. Electroconvulsive stimulation (ECS) regulates diverse neurotransmitter systems and induces anticonvulsant effects, properties implicated in mediating therapeutic effects of ECT. Somatostatin (SST) is a candidate for mediating these effects because it is upregulated by ECS and exerts seizure-suppressant effects...
March 21, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29555764/ultrastructure-of-shewanella-oneidensis-mr-1-nanowires-revealed-by-electron-cryotomography
#18
Poorna Subramanian, Sahand Pirbadian, Mohamed Y El-Naggar, Grant J Jensen
Bacterial nanowires have garnered recent interest as a proposed extracellular electron transfer (EET) pathway that links the bacterial electron transport chain to solid-phase electron acceptors away from the cell. Recent studies showed that Shewanella oneidensis MR-1 produces outer membrane (OM) and periplasmic extensions that contain EET components and hinted at their possible role as bacterial nanowires. However, their fine structure and distribution of cytochrome electron carriers under native conditions remained unclear, making it difficult to evaluate the potential electron transport (ET) mechanism along OM extensions...
March 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29554621/the-association-between-endotoxin-in-house-dust-with-atopy-and-exercise-induced-bronchospasm-in-children-with-asthma
#19
Oluwafemi Oluwole, Donna C Rennie, Ambikaipakan Senthilselvan, Roland Dyck, Anna Afanasieva, Shelley Kirychuk, George Katselis, Joshua A Lawson
BACKGROUND: Studies have reported protective and adverse associations between microbial exposure and childhood asthma. However, among children with asthma the relationships between endotoxin and exercise-induced bronchospasm (EIB) is less clear. OBJECTIVE: We investigated the association between exposure to endotoxin in house dust with atopy and EIB in children with asthma. METHODS: A cross-sectional survey was conducted among schoolchildren (aged 7-17 years) in the province of Saskatchewan, Canada...
March 16, 2018: Environmental Research
https://www.readbyqxmd.com/read/29547752/early-and-late-postictal-cardiac-electrophysiological-changes-associated-with-low-moderate-and-high-dose-electroconvulsive-shocks
#20
Nagendra Madan Singh, T N Sathyaprabha, Kashyap Malthish, Jagadisha Thirthalli, Chittaranjan Andrade
BACKGROUND: Studies have examined the effects of electroconvulsive therapy (ECT) on human cardiac electrophysiology. However, no study has so far examined whether these effects vary with the magnitude of the electrical dose used to elicit the seizure. Because the benefits and adverse effects of the ECT seizure are dose-dependent, we examined the effects of different electrical doses of electroconvulsive shocks (ECS) on cardiac electrophysiology in an animal model with a view to determine whether cardiac electrophysiology could be a useful proxy to evaluate the quality of the ECT seizure...
March 2, 2018: Asian Journal of Psychiatry
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