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Hongyu Sun, Jiajia Tang, Yongchao Mou, Jing Zhou, Linlin Qu, Kayla Duval, Zhu Huang, Ning Lin, Ruiwu Dai, Chengxiao Liang, Zi Chen, Lijun Tang, Fuzhou Tian
: Carbon nanotube (CNT)-based hydrogels have been shown to support cardiomyocyte growth and function. However, their role in cellular integrity among cardiomyocytes has not been studied in detail and the mechanisms underlying this process remain unclear. Here, single walled CNTs incorporated into gelatin with methacrylate anhydride (CNT/GelMA) hydrogels were utilized to construct cardiac tissues, which enhanced cardiomyocyte adhesion and maturation. Furthermore, through the use of immunohistochemical staining, transmission electron microscopy and intracellular calcium transient measurement, the incorporation of CNTs into the scaffolds was observed to markedly enhance the assembly and formation in the cardiac constructs...
October 18, 2016: Acta Biomaterialia
Elvira Boere, Astrid M Kamperman, Arianne E van 't Hoog, Walter W van den Broek, Tom K Birkenhäger
Electroconvulsive therapy (ECT) is considered an effective treatment for major depression with melancholic features. However, neurocognitive side-effects such as anterograde amnesia still regularly occur. The present study aims to evaluate the severity and course of anterograde amnesia in severely depressed patients undergoing ECT. In a prospective naturalistic study, anterograde memory function was assessed among inpatients who underwent ECT (n = 11). Subjects met DSM-IV criteria for major depressive disorder...
2016: PloS One
Kei Itagaki, Minoru Takebayashi, Chiyo Shibasaki, Naoto Kajitani, Hiromi Abe, Mami Okada-Tsuchioka, Shigeto Yamawaki
BACKGROUND: While electroconvulsive therapy (ECT) treatment for depression is highly effective, the high rate of relapse is a critical problem. The current study investigated factors associated with the risk of relapse in mood disorders in patients in which ECT was initially effective. METHOD: The records of 100 patients with mood disorders (61 unipolar depression, 39 bipolar depression) who received and responded to an acute ECT course were retrospectively reviewed...
October 11, 2016: Journal of Affective Disorders
Mohammad Haghighi, Abbas Sedighinejad, Bahram Naderi Nabi, Cyrus Emiralavi, Gelareh Biazar, Kaveh Mirmozaffari, Cyrus Zahedan, Mehdi Jafari
BACKGROUND: Electroconvulsive therapy (ECT) is a safe and effective mode of therapy for a wide variety of psychiatric disorders. However, it is associated with some disturbing side effects, such as nausea and vomiting, dental and tongue injury, confusion, dizziness, headache, and myalgia. OBJECTIVES: The present study focused on the evaluation of myalgia and headache and their predictors after ECT. PATIENTS AND METHODS: A prospective analytical descriptive study was conducted from October 2014 to January 2015, in an academic hospital in northern Iran...
June 2016: Anesthesiology and Pain Medicine
N Tozon, P Kramaric, V Kos Kadunc, G Sersa, M Cemazar
The aim of our study was to evaluate the efficacy of electrochemotherapy (ECT) with cisplatin as a single or adjuvant treatment for sarcoids in equids. Different treatment options with different success rates were proposed. Thirty-one horses and one donkey with different clinical type, size and location of tumours were treated with ECT as a single treatment (18 animals with 52 tumour nodules) or as adjuvant treatment with marginal surgical excision (14 animals with 18 tumour nodules). In animals treated only with ECT with cisplatin, complete response was obtained in 48/52 (92...
October 7, 2016: Veterinary Record
Giulio Perugi, Pierpaolo Medd, Pierpaolo Medd, Cristina Toni, Michela Giorgi Mariani, Chiara Socci, Mauro Mauri
OBJECTIVE: We evaluated the effectiveness of Electroconvulsive Therapy (ECT) in the treatment of Bipolar Disorder (BD) in a large sample of bipolar patients with drug resistant depression, mania, mixed state and catatonic features. METHOD: 522 consecutive patients with DSM-IV-TR BD were evaluated prior to and after the ECT course. Responders and nonresponders were compared in subsamples of depressed and mixed patients. Descriptive analyses were reported for patients with mania and with catatonic features...
October 17, 2016: Current Neuropharmacology
Mikkel Vestergaard Olesen, Gitta Wörtwein, Jonas Folke, Bente Pakkenberg
Electroconvulsive stimulation (ECS) is one of the strongest stimulators of hippocampal neurogenesis in rodents that represents a plausible mechanism for the efficacy of electroconvulsive therapy (ECT) in major depressive disorder. Using design-based stereological cell counting, we recently documented an initial 2.6-fold increase in neurogenesis following a clinical relevant schedule of ECS, a treatment also rescuing depression-like behavior in rats. However, these results gave no demonstration of the longevity of newly-generated neurons...
October 18, 2016: Hippocampus
Albert Bortolotti
No abstract text is available yet for this article.
October 7, 2016: Journal of ECT
Qian Li, Yun-Ai Su, Yu-Tao Xiang, Liang Shu, Xin Yu, Gabor S Ungvari, Stephen J Seiner, Helen F K Chiu, Yu-Ping Ning, Gao-Hua Wang, Ke-Rang Zhang, Tao Li, Li-Zhong Sun, Jian-Guo Shi, Xian-Sheng Chen, Qi-Yi Mei, Ke-Qing Li, Tian-Mei Si
OBJECTIVE: Little is known about electroconvulsive therapy (ECT) use in the treatment of schizophrenia in China. This study examined the frequency of ECT use, its trend between 2006 and 2012, and its independent demographic and clinical correlates in a nationwide survey in China. METHODS: A total of 5162 inpatients in 45 Chinese psychiatric hospitals/centers were interviewed (2696 in 2006 and 2466 in 2012). Patients' sociodemographic and clinical characteristics were recorded using a standardized protocol and data collection procedure...
October 7, 2016: Journal of ECT
Pia Baldinger-Melich, Ana Weidenauer, Christoph Linder, Marius Hienert, Siegfried Kasper, Mara Stamenkovic, Matthäus Willeit
No abstract text is available yet for this article.
October 7, 2016: Journal of ECT
Wenlong Liu, Xiuli Dan, Ting Wang, William Weijia Lu, Haobo Pan
The development of an optimal animal model which could provide fast assessments of the interaction between bone and orthopaedic implants is essential for both pre-clinical and theoretical researches in the design of novel biomaterials. Compared with other animal models, mice have superiority in accessing the well-developed transgenic modification techniques (e.g. cell tracing, knock-off, knock-in ect.) which serve as powerful tools in studying molecular mechanisms. In this study, we introduced the establishment of a mouse model which is specifically tailored for the assessment of bone-implant interaction in a load-bearing bone marrow microenvironment and could potentially allow the molecular mechanism study of biomaterials by using transgenic technologies...
October 12, 2016: Tissue Engineering. Part C, Methods
Feng-Rong An, Ling Zhang, Qing-E Zhang, Gabor S Ungvari, Chee H Ng, Helen F K Chiu, Ping-Ping Wu, Xin Jin, Lu Li, Grace K I Lok, Yu-Tao Xiang
Little is known about the pattern of electroconvulsive therapy (ECT) use in the clinical population in China. This study examined the percentage of ECT use and its association with clinical characteristics and quality of life (QOL) in a psychiatric center in China that caters for a population of 20 million. A total sample of 1364 inpatients was consecutively recruited for the study. Demographic and clinical data including the use of ECT were collected. Psychopathology, activity of daily living and QOL were measured using standardized instruments...
September 28, 2016: Psychiatry Research
Nadia Musco, Serena Calabro, Raffaella Tudisco, Micaela Grossi, Laura Addi, Giuseppe Moniello, Pietro Lombardi, Monica Isabella Cutrignelli
In the paper the short- and long-term glycaemic response after 4 diet programmes was evaluated. Each diet programme was alternatively administered to 6 healthy cats for 30 days. At the end of each period cats were weighed and underwent blood sampling for glucose and fructosamine determination. Glycaemia was measured every 2 hours for 24 hours using an automated glucometer. Very high protein level and low starch (VHP/LS) and high protein and moderate starch level (HP/LS) diets showed glucose (Mean and Peak) and fructosamine values signi cantly lower compared to the moderate protein and high starch diets (MP/HS)...
August 3, 2016: Veterinaria Italiana
Natalia Golender, Alexander Panshin, Jacob Brenner, Ditza Rotenberg, Chris Oura, Evgeny Khinich, Velizar Bumbarov
Bluetongue (BT), an arthropod-borne viral disease of ruminants, a ects sheep most severely than other domestic animals. Bluetongue virus serotype 24 (BTV-24) is one of 26 known Bluetongue virus (BTV) serotypes. In this article, we present data of phylogenetic analysis of 9 viral genes (Seg1, Seg2, Seg3, Seg4, Seg5, Seg6, Seg8, Seg9, and Seg10) from 8 Israeli BTV-24 isolates and relate the genotype of the BTV-24 isolates to their phenotype with regard to clinical manifestations. The high level of genetic identity (> 99...
September 30, 2016: Veterinaria Italiana
Ana Carolina Diniz Matos, Mario Felipe Alvarez Balaro, Maria Isabel Maldonado Coelho Guedes, Erica Azevedo Costa, Ju Lio Ce Sar Ca Mara Rosa, Aristo Teles Gomes Costa, Felipe Zandonadi Branda O, Ze Lia Ine S Portela Lobato
In January 2013, an outbreak of Bluetongue (BT) a ecting a Lacaune sheep ock occurred in Vassouras, Rio de Janeiro state, Brazil. From March to August 2013, blood samples collection and clinical examination were performed monthly, in order to monitor the epidemiological pro le of Bluetongue virus (BTV) circulation and clinical disease in the ock. Agar gel immunodi usion (AGID) and reverse transcription polymerase chain reaction (RT-PCR) targeting BTV segment 10 were used as diagnostic assays. Additionally, insect trapping was conducted in the farm from May to July 2013...
September 30, 2016: Veterinaria Italiana
Sophette Gers, Christiaan Potgieter, Isabella Wright, Belinda Peyrot
Bluetongue virus (BTV) was sporadically isolated over a four year period (2010-2014) from several alpaca carcasses that were presented for necropsy at the Western Cape Provincial Veterinary Laboratory, South Africa. Typically, the a ected animals had a history of acute dyspnoea and progressive weakness before death. Consistent hydrothorax and severe lung oedema in all lead to a preliminary diagnosis of Bluetongue, despite the absence of ulceration and hyperaemia of the oral mucosa which is characteristic of this viral infection in sheep...
September 30, 2016: Veterinaria Italiana
Simon Carpenter
In the 10 years, since the last international meeting on Bluetongue virus (BTV) and related Orbiviruses in Sicily, there have been huge advances in explorations of the genetics and genomics of Culicoides, culminating in the imminent release of the rst full genome de novo assembly for the genus. In parallel, mathematical models used to predict Culicoides adult distribution, seasonality, and dispersal have also increased in sophistication, re ecting advances in available computational power and expertise. While these advances have focused upon the outbreaks of BTV in Europe, there is an opportunity to extend these techniques to other regions as part of global studies of the genus...
September 30, 2016: Veterinaria Italiana
Lauri Johannes Partanen, Hanna Vehkamaki, Klavs Hansen, Jonas Elm, Henning Henschel, Theo Kurtén, Roope Halonen, Evgeni Zapadinsky
In this article we show how to calculate free energies for atmospherically relevant complexes when multiple conformers and/or isomers are present. We explain why the thermal averaging methods used in several published works are not correct. Based on our two sample cases, the sulfuric acid - pinic acid complex and the (H2SO4)3(NH3)3(H2O)4 cluster,we provide numerical evidence that the use of these incorrect formulae can result in errors larger than one kcal/mol. We recommend that if vibrational frequencies and thus Gibbs free energies of the individual conformers are unavailable, one should not attempt to correct for the presence of multiple conformers and instead use only the global minimum conformers for both reactants and products...
October 4, 2016: Journal of Physical Chemistry. A
S Maguire, S M Rea, P Convery
BACKGROUND: The Regulation and Quality Improvement Authority (RQIA) monitors the administration of electroconvulsive therapy (ECT) in Northern Ireland (NI). As part of their inspection methodology RQIA wished to include feedback from ECT patients. The aim of this report is to summarise the opinions of ECT patients over a 1-year period and to compare their feedback about treatment with the standards of best practice, as defined by the Electroconvulsive Therapy Accreditation Service (ECTAS)...
September 2016: Ulster Medical Journal
Tanja Dolinsek, Lara Prosen, Maja Cemazar, Tjasa Potocnik, Gregor Sersa
BACKGROUND: The aim of the study was to explore the effectiveness of electrochemotherapy (ECT) during the treatment of melanoma patients with BRAF inhibitors. Its effectiveness was tested on BRAF mutated and non-mutated melanoma cells in vitro and in combination with BRAF inhibitors. MATERIALS AND METHODS: ECT with bleomycin was performed on two human melanoma cell lines, with (SK-MEL-28) or without (CHL-1) BRAF V600E mutation. Cell survival was determined using clonogenic assay to determine the effectiveness of ECT in melanoma cells of different mutation status...
September 1, 2016: Radiology and Oncology
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