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Barbara Staresinic, Tanja Jesenko, Urska Kamensek, Stine Krog Frandsen, Gregor Sersa, Julie Gehl, Maja Cemazar
Calcium electroporation (CaEP) is a novel anti-tumour treatment that induces cell death by internalization of large quantities of calcium. The anti-tumour effectiveness of CaEP has been demonstrated in vitro, in vivo, and in preliminary clinical trials; however, its effects on the vasculature have not been previously investigated. Using a dorsal window chamber tumour model, we observed that CaEP affected to the same degree normal and tumour blood vessels in vivo, as it disrupted the vessels and caused tumour eradication by necrosis...
June 20, 2018: Scientific Reports
Vytautas Jankauskas, Candace Necyk, James Chue, Pierre Chue
Up to 20% of depressed patients demonstrate treatment resistance to one or more adequate antidepressant trials, resulting in a disproportionately high burden of illness. Ketamine is a non-barbiturate, rapid-acting general anesthetic that has been increasingly studied in treatment resistant depression (TRD), typically at sub-anesthetic doses (0.5 mg/kg over 40 min by intravenous infusion). More recent data suggest that ketamine may improve response rates to electroconvulsive therapy (ECT) when used as an adjunct, but also as a sole agent...
2018: Neuropsychiatric Disease and Treatment
Pierpaolo Medda, Chiara Socci, Cristina Toni, Irene Pergentini, Francesco Forfori, Filippo Sean Giorgi, Giulio Perugi
No abstract text is available yet for this article.
June 15, 2018: Journal of Clinical Psychopharmacology
Sertaç Ak, Nadir Yalçin
PURPOSE: Whether the antiepileptic agents used by patients before the treatment should be discontinued after the initiation of the electroconvulsive therapy (ECT), which is one of the most effective treatment options in psychiatry, is a dilemma frequently faced by clinicians. Recently, there has been an increased interest in this subject. This study aimed to determine the impact of antiepileptic agents on ECT process in the event of continued use in the course of the therapy. METHODS: From among the patients on an ECT therapy in the Psychiatry Clinic of Hacettepe University Hospital since 2010, a total of 39 patients who continued to use the antiepileptic agent they were taking prior to the ECT therapy were determined and included in the study...
June 14, 2018: Journal of Clinical Psychopharmacology
Chun-Hung Chang, Hsien-Yuan Lane, Chieh-Hsin Lin
Brain stimulation techniques can modulate cognitive functions in many neuropsychiatric diseases. Pilot studies have shown promising effects of brain stimulations on Alzheimer's disease (AD). Brain stimulations can be categorized into non-invasive brain stimulation (NIBS) and invasive brain stimulation (IBS). IBS includes deep brain stimulation (DBS), and invasive vagus nerve stimulation (VNS), whereas NIBS includes transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), electroconvulsive treatment (ECT), magnetic seizure therapy (MST), cranial electrostimulation (CES), and non-invasive VNS...
2018: Frontiers in Psychiatry
Jiangling Jiang, Qingwei Li, Jianhua Sheng, Fuzhong Yang, Xinyi Cao, Tianhong Zhang, Yuping Jia, Jijun Wang, Chunbo Li
Magnetic seizure therapy (MST) is a potential alternative to electroconvulsive therapy (ECT), but there is currently a lack of reports about MST in Chinese patients with schizophrenia. Our objective was to investigate the feasibility and acceptability of add-on MST in the treatment of patients with schizophrenia. Eight patients with schizophrenia were enrolled in a case series study to receive 10 sessions of add-on MST over 4 weeks. The MST was administrated using 25 Hz at 100% output with a titration duration ranging from 4 to 20 s by 4 s...
2018: Frontiers in Psychiatry
Oriana De Vos, Richard M Venable, Tanja Van Hecke, Gerhard Hummer, Richard Walter Pastor, An Ghysels
The balance of normal and radial (lateral) diffusion of oxygen in phospholipid mem-branes is critical for biological function. Based on the Smoluchowski equation for the inhomogeneous solubility-diffusion model, Bayesian analysis (BA) can be applied to molecular dynamics trajectories of oxygen to extract the free energy, and the normal and radial diffusion profiles. This paper derives a theoretical formalism to convert these profiles into characteristic times and lengths associated with entering, escaping, or completely crossing the membrane...
June 12, 2018: Journal of Chemical Theory and Computation
K W Miskowiak, J Macoveanu, M B Jørgensen, C V Ott, M M Støttrup, H M Jensen, A Jørgensen, C J Harmer, O B Paulson, H R Siebner, L V Kessing
Electroconvulsive therapy (ECT) is the most effective treatment for severe depression but its neurocognitive mechanisms are unclear. This randomized, sham-controlled functional magnetic resonance imaging (fMRI) study explored the effects of a single ECT on neural response to affective pictures. Twenty-seven patients with major depressive disorder were randomized to a single active ECT (N = 15) or sham (N = 12) session in a double-blind, parallel-group design. On the following day, patients underwent fMRI during which they viewed pleasant, unpleasant and neutral pictures and performed a free recall test after the scan...
June 8, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Anna M Perrone, Andrea Galuppi, Giulia Borghese, Barbara Corti, Martina Ferioli, Anna N Della Gatta, Alessandro Bovicelli, Alessio G Morganti, Pierandrea De Iaco
BACKGROUND AND OBJECTIVES: Previous studies showed a local tumor control of 80% in patients with relapsed squamous cell vulvar cancer (V-SCC) treated with electrochemotherapy. These results encouraged electrochemotherapy use as neo-adjuvant treatment in V-SCC. The objective of this study was to evaluate the effectiveness of electrochemotherapy in reducing tumor burden in V-SCC. METHODS: Patients with histological diagnosis of primary V-SCC eligible for surgery were enrolled...
June 7, 2018: Journal of Surgical Oncology
Mengqing Xia, Junjie Wang, Jianhua Sheng, Yingying Tang, Chunyan Li, Kelvin Lim, Bin He, Chunbo Li, Yifeng Xu, Jijun Wang
OBJECTIVE: Electroconvulsive therapy (ECT) has often been applied to augment antipsychotics for schizophrenia patients. However, the underpinning mechanism is still unclear. Previous studies of major depressive disorder reported an increase in γ-aminobutyric acid (GABA) after ECT. The present study investigated the effects of ECT on medial prefrontal GABA in schizophrenia using a proton magnetic resonance spectroscopy. METHODS: Inpatients fulfilling the diagnostic criteria for schizophrenia (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) were assigned to 2 groups, ECT group (n = 14) receiving ECT plus antipsychotic drugs (APD) and drug group (n = 17) only receiving antipsychotic drugs...
June 5, 2018: Journal of ECT
Laura Kranaster, Suna Su Aksay, Jan Malte Bumb, Carolin Hoyer, Christine Jennen-Steinmetz, Alexander Sartorius
Early identification of patients at high risk for an unfavorable outcome to ECT during the course might be beneficial because it provides an opportunity for timely intensification or optimization of stimulus conditions. We aimed to develop a new Seizure Quality Index (SQI) that delivers a clinical relevant outcome prediction early in the treatment course and can be used within common clinical setting. An observational study was conducted. Patients (n = 86) with a depressive episode and the clinical decision for ECT (right unilateral, brief pulse) were included, and several ictal parameters derived from the second ECT session and the clinical outcome of the patients were documented...
June 6, 2018: European Archives of Psychiatry and Clinical Neuroscience
Himanshu Singla, Sandeep Grover
Electroconvulsive therapy (ECT) is one of the safest treatment options for psychiatric illnesses with no absolute contraindications. However, certain medical conditions including cardiac ailments such as aortic stenosis are associated with increased risk with ECT. We present the case of a 74-year-old female who was suffering from severe depression with psychotic symptoms (which had not responded to two adequate trials of antidepressants), along with severe aortic stenosis, who was managed with modified bilateral ECT and review the available literature...
May 2018: Indian Journal of Psychological Medicine
Florian M Rossmann, Morgan Beeby
In situ structural information on molecular machines can be invaluable in understanding their assembly, mechanism and evolution. Here, the use of electron cryotomography (ECT) to obtain significant insights into how an archetypal molecular machine, the bacterial flagellar motor, functions and how it has evolved is described. Over the last decade, studies using a high-throughput, medium-resolution ECT approach combined with genetics, phylogenetic reconstruction and phenotypic analysis have revealed surprising structural diversity in flagellar motors...
June 1, 2018: Acta Crystallographica. Section D, Structural Biology
Pavan Kumar Kadiyala, Lakshmi Deepthi Kadiyala
PURPOSE OF REVIEW: Electroconvulsive therapy (ECT) as a treatment option in psychiatry is advancing day by day. This review discusses new advancements in ECT with regards to anesthetic variables, stimulus, and response variables along with their impact on clinical outcomes. RECENT FINDINGS: Anesthetic variables influence clinical efficacy and patient tolerance of ECT. Although etomidate or a ketamine-propofol combination may be the first choice for many clinicians, the search for ideal induction agent continues...
June 4, 2018: Current Opinion in Anaesthesiology
Ben J A Palanca, Hannah R Maybrier, Angela M Mickle, Nuri B Farber, R Edward Hogan, Emma R Trammel, J Wylie Spencer, Donald D Bohnenkamp, Troy S Wildes, ShiNung Ching, Eric Lenze, Mathias Basner, Max B Kelz, Michael S Avidan
Electroconvulsive therapy (ECT) employs the elective induction of generalizes seizures as a potent treatment for severe psychiatric illness. As such, ECT provides an opportunity to rigorously study the recovery of consciousness, reconstitution of cognition, and electroencephalographic (EEG) activity following seizures. Fifteen patients with major depressive disorder refractory to pharmacologic therapy will be enrolled (, NCT02761330). Adequate seizure duration will be confirmed following right unilateral ECT under etomidate anesthesia...
2018: Frontiers in Psychiatry
Tao Fan, Ju-Ying Zhou
We present a case of a 72-year male with primary lung squamous cell carcinoma without an epidermal growth factor receptor (EGFR) gene mutation that exhibited a lasting efficacy to icotinib treatment. Originally, the patient was treated with GP regimen for 2 cycles, local lesion radiotherapy (DT46Gy/2Gy*23F), and TP regimen for 2 cycles, with efficacy evaluation as stable disease (SD). The condition was stable for 10 months until the fifth lumbar metastasis was discovered by emission computed tomography (ECT) in July 2015, and the pulmonary metastasis increased...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Han-Bing Song, Ying Jiang, Jia-Xing Liu, Ge-Qiang Wang, Da-Peng Zhang, Yi-Chang Jiang, Shu-Jun Ren, Hong-Peng Liu, Xue-Yan Jiang
A capsule of Qili Jiegu, a traditional Chinese medicine with numerous biological activities, may exert a protective eff ;ect against postmenopausal bone loss. However, it remains unclear whether Qili Jiegu-containing serum regulates the osteogenic diff ;erentiation of bone marrow stromal cells (BMSCs) in vitro. In this study, BMSCs were treated with medium and Qili Jiegu-containing serum over a 14-day period. We found that Qili Jiegu-containing serum promoted the BMSC proliferation and alkaline phosphatase (ALP) activities, as well as stimulated the expression of osteogenic markers and Wnt/β-catenin pathway-related genes, i...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Shakeel Ijaz, Naveed Akhtar, Muhammad Shoaib Khan, Abdul Hameed, Muhammad Irfan, Muhammad Adeel Arshad, Sajid Ali, Muhammad Asrar
Plants have been used as medicinal agents since the origin of mankind. High cost and severe side effects associated with conventional chemotherapy has limited their general acceptability and fuel up the search for alternate options. The alternative treatment options like phytochemicals have come up with ease of availability and cost effectiveness. Owing to their general acceptance, safety, low side effects and multistep targeting in signal transduction pathways, plant derived phyto-constituents have promising anti-carcinogenic potential for skin related cancers...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Alma Mihaljević-Peleš, Maja Bajs Janović, Ana Stručić, Marina Šagud, Milena Skočić HanŽek, Maja Živković, Špiro Janović
Despite controversy, ECT has been recognized as significantly effective for the treatment of mental disorders since 1938, when Cerletti and Bini introduced ECT in clinical psychiatric practice for treatment of schizophrenia. In the next period, indication for ECT switched more toward depression and catatonia. ECT was even banned from psychiatric training in 1960's, due to the anti-psychiatric movement, which were fortified by Oscar winning movie "One Flew over the Cuckoo's Nest". Due to its robust effectiveness, ECT revived in the early 1980's and today holds its position in clinical psychiatric practices around the world...
June 2018: Psychiatria Danubina
Misako Kanayama, Tsuyoshi Miyaoka, Tomoko Araki, Maiko Hayashida, Sadayuki Hashioka, Jun Horiguchi
Background: Dysfunction of the autonomic nervous system (ANS) in schizophrenia has been detected by electrophysiological methods, but the underlying mechanisms remain unknown. Several studies have suggested that measuring salivary alpha-amylase activity levels is useful for evaluating the ANS activity and that sAA levels increase in schizophrenia and correlate with Brief Psychiatric Rating Scale (BPRS) scores. However, no study has examined the relationship between sAA activity levels and symptoms of schizophrenia with catatonic state...
2018: Case Reports in Psychiatry
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