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https://www.readbyqxmd.com/read/29031207/microrna-25-inhibits-high-glucose-induced-apoptosis-in-renal-tubular-epithelial-cells-via-pten-akt-pathway
#1
Huicong Li, Xiaoguang Zhu, Junwei Zhang, Jun Shi
Diabetic nephropathy (DN) has become the major cause of end-stage renal disease (ESRD). It has been demonstrated that apoptosis of renal tubular epithelial cells induced by hyperglycemia contributes to the pathogenesis of DN. Recent researches have corroborated the critical roles of microRNAs (miRNAs) in the apoptosis of various types of cells including renal tubular epithelial cells. However, the eff ; ;ect of miRNAs on the hyperglycemia-induced apoptosis of renal tubular epithelial cells remains unclear...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29025075/possible-association-between-serum-matrix-metalloproteinase-9-mmp-9-levels-and-relapse-in-depressed-patients-following-electroconvulsive-therapy-ect
#2
Chiyo Shibasaki, Kei Itagaki, Hiromi Abe, Naoto Kajitani, Mami Okada-Tsuchioka, Minoru Takebayashi
Background: Matrix metalloproteinase (MMPs) are involved in neuroinflammatory processes, which could underlie depression. Serum levels of MMP-9 and MMP-2 in depressed patients are significantly altered following electroconvulsive therapy (ECT), but an association between altered MMPs after successful ECT and possible relapse has yet to be investigated. Methods: Serum was obtained twice, before and immediately after a course of ECT, from 38 depressed patients. Serum was also collected, once, from two groups of age- and gender-matched healthy controls, 40 volunteers in each group...
September 16, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29024870/comparable-effectiveness-and-immunomodulatory-actions-of-oxaliplatin-and-cisplatin-in-electrochemotherapy-of-murine-melanoma
#3
Katja Ursic, Spela Kos, Urska Kamensek, Maja Cemazar, Janez Scancar, Simon Bucek, Simona Kranjc, Barbara Staresinic, Gregor Sersa
Interest in platinum-based chemotherapeutics such as oxaliplatin (OXA) and cisplatin (CDDP) has been reinvigorated by their newly described impacts on tumor-specific immune responses. In addition to CDDP, OXA is frequently used to treat cancers. Based on the characteristics of OXA, which are similar to those of CDDP, and the presumably more pronounced immunomodulatory effect of OXA, OXA is a candidate for electrochemotherapy (ECT). We compared the effectiveness of intratumoral ECT with OXA to that of ECT with CDDP in murine B16F10 melanoma to determine the equieffective dose...
October 3, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29023285/predictors-of-electroconvulsive-therapy-use-in-a-large-inpatient-psychiatry-population
#4
Julia Knight, Micaela Jantzi, John Hirdes, Terry Rabinowitz
OBJECTIVE: There is limited research on reliable and clinically useful predictors of electroconvulsive therapy (ECT) use. We aimed to examine factors that predict ECT use in an inpatient psychiatric population. DESIGN: Retrospective analysis of provincial database for inpatient psychiatry. METHODS: This study is a retrospective analysis of a provincial database for inpatient psychiatry. The study includes all psychiatric inpatients 18 years or older in Ontario, Canada, assessed with the Resident Assessment Instrument for Mental Health (RAI-MH) within the first 3 days of admission between 2009 and 2014 (n = 153,023)...
October 12, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28991068/regulation-of-electroconvulsive-therapy-a-systematic-review-of-us-state-laws
#5
Robin Livingston, Chester Wu, Kathy Mu, M Justin Coffey
OBJECTIVES: The goal of this study was to systematically review current US state laws on electroconvulsive therapy (ECT) in order to provide a comprehensive resource to educate practitioners, potential patients, and lawmakers. METHODS: Individual state legislative Web sites were searched by 2 independent authors using the following search terms: "electroconvulsive therapy," "convulsive therapy," "electroconvulsant therapy," "electroshock therapy," and "shock therapy" from March 2017 to May 2017...
October 3, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28989984/hippocampal-volume-changes-following-electroconvulsive-therapy-a-systematic-review-and-meta-analysis
#6
Samuel T Wilkinson, Gerard Sanacora, Michael H Bloch
INTRODUCTION: Reduced hippocampal volume is one of the most consistent morphological findings in Major Depressive Disorder (MDD). Electroconvulsive therapy (ECT) is the most effective therapy for MDD, yet its mechanism of action remains poorly understood. Animal models show that ECT induces several neuroplastic processes, which lead to hippocampal volume increases. We conducted a meta-analysis of ECT studies in humans to investigate its effects on hippocampal volume. METHODS: PubMed was searched for studies examining hippocampal volume before and after ECT...
May 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28982047/rehospitalization-and-suicide-following-electroconvulsive-therapy-for-bipolar-depression-a-population-based-register-study
#7
Katarzyna Popiolek, Ole Brus, Tove Elvin, Mikael Landén, Johan Lundberg, Pia Nordanskog, Axel Nordenskjöld
BACKGROUND: Electroconvulsive therapy (ECT) is effective in bipolar depression, but relapse is common. The aim of the study was (i) to identify prognostic factors (ii) and to determine the impact of pharmacological approaches on the risk for rehospitalization or suicide. METHODS: This register study analyzed data from individuals treated with inpatient ECT for bipolar depression. Subjects were identified using the Swedish National Patient Register between 2011 and 2014 and the Swedish National Quality Register for ECT...
September 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28981882/electroconvulsive-therapy-selectively-enhanced-feedforward-connectivity-from-fusiform-face-area-to-amygdala-in-major-depressive-disorder
#8
Jiaojian Wang, Qiang Wei, Tongjian Bai, Xiaoqin Zhou, Hui Sun, Benjamin Becker, Yanghua Tian, Kai Wang, Keith Kendrick
Electroconvulsive therapy (ECT) has been widely used to treat the major depressive disorder (MDD), especially for treatment resistant depression. However, the neuroanatomical basis of ECT remains an open problem. In our study, we combined the voxel-based morphology (VBM), resting-state functional connectivity (RSFC), and granger causality analysis (GCA) to identify the longitudinal changes of structure and function in 23 MDD patients before and after ECT. In addition, multivariate pattern analysis using linear support vector machine (SVM) was applied to classify 23 depressed patients from 25 gender, age, and education matched healthy controls...
August 28, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28976441/validation-of-the-10-item-orientation-questionnaire-a-new-tool-for-monitoring-post-electroconvulsive-therapy-disorientation
#9
Donel M Martin, Ada Wong, Divya R Kumar, Colleen K Loo
OBJECTIVES: Assessment of post-electroconvulsive therapy (ECT) disorientation at a single time point after ECT treatment may prove an effective and clinically useful method for monitoring the severity of disorientation and predicting ECT-induced retrograde amnesia. In this study, we aimed to validate a novel instrument (10-Item Orientation Questionnaire) developed to assess the level of disorientation after ECT. METHODS: Twenty-four depressed inpatients who were prescribed an acute course of ECT were administered the 10-Item Orientation Questionnaire at 30 minutes after ECT and had time to reorientation assessed at 3 time points after ECT (10, 30, and 60 minutes) at ECT treatments 1 to 3...
October 3, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28976440/electroconvulsive-therapy-in-a-patient-with-a-recent-subarachnoid-hemorrhage
#10
Seshagiri Rao Doddi, Matthew Lotz, William T Regenold, Lawrence Adler
The safety of electroconvulsive therapy (ECT) is improving with advances in anesthesia and ECT technique. There are published case reports of successful treatment of depression in patients who were once considered at high medical risk. Recent cerebral hemorrhage is one of the conditions considered to significantly increase the risk of ECT treatment. Literature search did not indicate any case reports of ECT treatment in patients with recent subarachnoid hemorrhage. We report the successful ECT treatment of depression in an older man who had developed a subarachnoid hemorrhage after a suicide attempt by ingestion of antifreeze...
October 3, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28975998/peripheral-blood-microrna-and-vegfa-mrna-changes-following-electroconvulsive-therapy-implications-for-psychotic-depression
#11
E Kolshus, K M Ryan, G Blackshields, P Smyth, O Sheils, D M McLoughlin
OBJECTIVE: MicroRNAs are short, non-coding molecules that regulate gene expression. Here, we investigate the role of microRNAs in depression and electroconvulsive therapy (ECT). METHODS: We performed three studies: a deep sequencing discovery-phase study of miRNA changes in whole blood following ECT (n = 16), followed by a validation study in a separate cohort of patients pre-/post-ECT (n = 37) and matched healthy controls (n = 34). Changes in an experimentally validated gene target (VEGFA) were then analysed in patients pre-/post-ECT (n = 97) and in matched healthy controls (n = 53)...
October 4, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28970429/competence-based-curricula-in-the-context-of-bologna-and-eu-higher-education-policy
#12
Howard Davies
At the turn of the century European higher education policy became twin-track. The Bologna Process was launched and ran alongside developments in European legislation. Both tracks displayed a preoccupation with competences, in relation both to citizenship and to labour market needs. Scrutiny of important policy texts (Key Competences, the European Qualifications Framework, ECTS, the Bologna three-cycle degree structure) shows that 'competence' has never been given a precise and secure definition. Only very recently has the term entered the discourse of EU legislation on the recognition of professional qualifications...
March 26, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/28959168/electrochemotherapy-supplementary-treatment-for-loco-regional-metastasized-breast-carcinoma-administered-to-concomitant-systemic-therapy
#13
Eva-Maria Grischke, Carmen Röhm, Eva Stauß, Florin-Andrei Taran, Sara Y Brucker, Diethelm Wallwiener
BACKGROUND: Electrochemotherapy (ECT) is an established procedure for treating breast cancer loco-regional recurrences following surgical intervention and/or radiotherapy. Limited information is available on ECT application as a concomitant procedure to systemic therapy in recurrent breast cancer. The primary objective of this study was to determine if the application of ECT in close temporal relation to systemic chemotherapy could lead to increased local and/or systemic side effects...
September 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28947147/differentiation-of-minute-virus-of-mice-and-mouse-parvovirus-by-high-resolution-melting-curve-analysis
#14
Dan Rao, Miaoli Wu, Jing Wang, Wen Yuan, Yujun Zhu, Feng Cong, Fengjiao Xu, Yuexiao Lian, Bihong Huang, Qiwen Wu, Meili Chen, Yu Zhang, Ren Huang, Pengju Guo
Murine parvovirus is one of the most prevalent infectious pathogens in mouse colonies. A specific primer pair targeting the VP2 gene of minute virus of mice (MVM) and mouse parvovirus (MPV) was utilized for high resolution melting (HRM) analysis. The resulting melting curves could distinguish these two virus strains and there was no detectable amplification of the other mouse pathogens which included rat parvovirus (KRV), ectromelia virus (ECT), mouse adenovirus (MAD), mouse cytomegalovirus (MCMV), polyoma virus (Poly), Helicobactor hepaticus (H...
September 23, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28940099/influence-of-depressed-patients-expectations-prior-to-electroconvulsive-therapy-on-its-effectiveness-and-tolerability-exp-ect-a-prospective-study
#15
Lisa Krech, Michael Belz, Matthias Besse, Isabel Methfessel, Dirk Wedekind, David Zilles
Electroconvulsive therapy (ECT) is the most effective therapy for severe depressive disorders. Though there are known clinical predictors of response (e.g., higher age, presence of psychotic symptoms), there is a lack of knowledge concerning the impact of patients' expectations on treatment outcome and tolerability in terms of possible placebo/nocebo effects. In 31 patients with unipolar or bipolar depressive disorder, we used a questionnaire to investigate the patients' expectations of ECT effectiveness and tolerability prior to and in the course of the treatment...
September 22, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28937549/electroconvulsive-therapy-for-super-refractory-status-epilepticus
#16
Jayme Ahmed, Michael Metrick, Anne Gilbert, Anita Glasson, Ranjeet Singh, Wayne Ambrous, Lori Brown, Laura Aykroyd, Karen Bobel
OBJECTIVES: Super refractory status epilepticus (SRSE) is a stage beyond refractory status that requires general anesthesia as management. Electroconvulsive therapy (ECT) is recommended only as a potential treatment option beyond general anesthesia and after all other options have been exhausted. Its effect on aborting status has been minimally researched. We present the largest case series to our knowledge exploring the effect of ECT on SRSE. METHODS: Eight adults hospitalized for SRSE received ECT in an attempt to abort status after other treatment modalities were exhausted...
September 20, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28937548/a-follow-up-study-of-electroconvulsive-therapy-in-children-and-adolescents
#17
Shanti Mitchell, Ehmer Hassan, Neera Ghaziuddin
OBJECTIVES: Electroconvulsive therapy (ECT) is an effective and a safe treatment for several severe psychiatric disorders across the age span. However, its use remains controversial and highly stigmatized especially among patients under 18 years. In this study, we examined current symptoms, attitudes, perception, and functioning of patients treated with ECT when they were less than 18 years old. METHODS: Participants had received ECT before age 18, between 1989 and 2015, at a tertiary medical center...
September 20, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28937547/management-of-emergency-electroconvulsive-therapy-in-the-intensive-care-unit-for-life-threatening-psychiatric-conditions-a-case-series
#18
Samuel Bulteau, Edouard-Jules Laforgue, Loïc Chimot, Romain Dumont, Olivier Loutrel, François Etcheverrigaray, Caroline Victorri-Vigneau, Alexandre Massri, Jean-Marie Vanelle, Anne Sauvaget
Catatonia can lead to severe complications and may be lethal but is often underdiagnosed. The clinical presentation can be similar to coma. In these situations, electroconvulsive therapy (ECT) can be used as first-line treatment to enable extubation, recovery of autonomy, and rapid discharge from intensive care. We report 4 cases of patients hospitalized in the intensive care unit with comatose clinical presentation and life-threatening condition caused by catatonia. All patients received ECT sessions, after which the catatonic symptoms partially or fully remitted...
September 20, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28937546/a-randomized-nonblind-naturalistic-comparison-of-efficacy-and-cognitive-outcomes-with-right-unilateral-bifrontal-and-bitemporal-electroconvulsive-therapy-in-schizophrenia
#19
Aniket Bansod, Sushma S Sonavane, Nilesh B Shah, Avinash A De Sousa, Chittaranjan Andrade
BACKGROUND: There is little literature on the relative efficacy and cognitive safety of right unilateral (RUL), bifrontal (BF), and bitemporal (BT) electroconvulsive therapy (ECT) in schizophrenia. METHODS: We present a randomized, nonblind, naturalist comparison of a fixed course of 8 moderately high-dose RUL (n = 24), threshold BF (n = 27), and threshold BT (n = 31) ECT in patients with schizophrenia. Assessments included the Positive and Negative Syndrome Scale (PANSS), the Wechsler Memory Scale-Revised, and an autobiographical memory interview...
September 20, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28936064/knowledge-and-attitude-of-nursing-students-toward-electroconvulsive-therapy
#20
Nitasha Sharma, Sandhya Ghai, Sandeep Grover
BACKGROUND: Electroconvulsive therapy (ECT) is one of the commonly used treatment modalities for patients with severe mental disorders. However, acceptance of ECT by the patient and relatives often depends on how the health-care professionals themselves present the treatment modality to the patients and their relatives. There is a lack of information about the knowledge and attitude toward ECT among health professionals. AIM: This study aimed to evaluate the knowledge about and attitude toward ECT among nursing students...
August 2017: Journal of Neurosciences in Rural Practice
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