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https://www.readbyqxmd.com/read/29456474/electrochemotherapy-in-breast-cancer-discussion-of-the-method-and-literature-review
#1
REVIEW
Mateusz Wichtowski, Dawid Murawa, Katarzyna Kulcenty, Karolina Zaleska
Breast cancer is the most common cause of skin metastases in women. The probability of their occurrence ranges from about 5% in the entire population to as much as 30% in the late stages of the disease. Although rarely life-threatening, they have a major impact on the quality of life of patients with this diagnosis, being the cause of pain, effusion, ulceration, infection, and psychological discomfort. Available methods of treatment, both local and systemic, often fail to provide adequate control of the disease...
December 2017: Breast Care
https://www.readbyqxmd.com/read/29453918/high-dose-of-histone-deacetylase-inhibitors-affects-insulin-secretory-mechanism-of-pancreatic-beta-cell-line
#2
Eiji Yamato
OBJECTIVE: Histone deacytylase inhibitors (HDACis) inhibit the deacetylation of the lysine residue of proteins, including histones, and regulate the transcription of a variety of genes. Recently, HDACis have been used clinically as anti-cancer drugs and possible anti-diabetic drugs. Even though HDACis have been proven to protect the cytokine-induced damage of pancreatic beta cells, evidence also shows that high doses of HDACis are cytotoxic. In the present study, we, therefore, investigated the eff ect of HDACis on insulin secretion in a pancreatic beta cell line...
January 1, 2018: Endocrine Regulations
https://www.readbyqxmd.com/read/29444385/improving-near-peer-teaching-quality-in-anatomy-by-educating-teaching-assistants-an-example-from-sweden
#3
Ellen Johansson, Tobias E Holmin, Bengt R Johansson, Magnus Braide
Peer-assisted learning has gained momentum in a variety of disciplines, including medical education. In Gothenburg, Sweden, medical students who have finished their compulsory anatomy courses have the option of working as teaching assistants (TAs). Teaching assistants provide small group teaching sessions as a complement to lectures given by faculty. Previously, TAs were left to handle the role as junior teachers by themselves, but since 2011, a continuation course in anatomy has been developed with the aim of providing the TAs better anatomy knowledge and guidance for teaching...
February 14, 2018: Anatomical Sciences Education
https://www.readbyqxmd.com/read/29442207/i-m-shocked-informed-consent-in-ect-and-the-phenomenological-self
#4
Patrick Seniuk
This paper argues that phenomenological insights regarding selfhood are relevant to the informed consent process in the treatment of depression using electro-convulsive therapy (ECT). One of the most significant side-effects associated with ECT is retrograde amnesia. Unfortunately, the current informed consent model does not adequately appreciate the full extent in which memory loss disturbs lived-experience. Through the philosophy of Merleau-Ponty, it is possible to appreciate the way in which memory loss affects a person's self-experience, with emphasis given to one's pre-reflective and embodied, relationship with things in the world...
February 13, 2018: Life Sciences, Society and Policy
https://www.readbyqxmd.com/read/29441189/neuroleptic-malignant-syndrome-a-case-responding-to-electroconvulsive-therapy-plus-bupropion
#5
Quintí Foguet-Boreu, Montse Coll-Negre, Montse Serra-Millàs, Miquel Cavalleria-Verdaguer
Neuroleptic malignant syndrome (NMS) is a severe motor syndrome occurring as a consequence of neuroleptic treatment. We present a case of a 67-year-old Caucasian woman with a history of a major depressive disorder with psychotic features. During her third hospital admission, symptoms of autonomic instability, hyperpyrexia, severe extrapyramidal side effects, and delirium appeared, suggesting NMS due to concomitant treatment with risperidone and quetiapine, among other drugs. Despite several consecutive pharmacological treatments (lorazepam, bromocriptine and amantadine) and prompt initiation of electroconvulsive therapy (ECT), clinical improvement was observed only after combining bupropion with ECT...
January 8, 2018: Clinics and Practice
https://www.readbyqxmd.com/read/29440375/preoperative-medical-treatment-in-cushing-s-syndrome-frequency-of-use-and-its-impact-on-postoperative-assessment-data-from-ercusyn
#6
Elena Valassi, Holger Franz, Thierry Brue, Richard A Feelders, Romana T Netea-Maier, Stylianos Tsagarakis, Susan M Webb, Maria Kostadinova Yaneva, Martin Reincke, Michael Droste, Irina Komerdus, Dominique Maiter, Darko Kastelan, Philippe Chanson, Marija Pfeifer, Christian J Strasburger, Miklos Toth, Olivier Chabre, Michal Krsek, Carmen Fajardo Montañana, Marek Bolanowski, Alicia Santos, Peter J Trainer, John A H Wass, Antoine Tabarin
BACKGROUND: Surgery is the definitive treatment of Cushing's syndrome (CS) but medications may also be used as a first-line therapy. Whether preoperative medical treatment (PMT) affects postoperative outcome remains controversial. OBJECTIVE: 1) Evaluate how frequently PMT is given to CS patients across Europe 2) examine differences in preoperative characteristics of patients who receive PMT and those who undergo primary surgery; 3) determine if PMT influences postoperative outcome in pituitary-dependent CS (PIT-CS)...
February 12, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29436330/prediction-of-electroconvulsive-therapy-response-and-remission-in-major-depression-meta-analysis
#7
Linda van Diermen, Seline van den Ameele, Astrid M Kamperman, Bernard C G Sabbe, Tom Vermeulen, Didier Schrijvers, Tom K Birkenhäger
BACKGROUND: Electroconvulsive therapy (ECT) is considered to be the most effective treatment in severe major depression. The identification of reliable predictors of ECT response could contribute to a more targeted patient selection and consequently increased ECT response rates. Aims To investigate the predictive value of age, depression severity, psychotic and melancholic features for ECT response and remission in major depression. METHOD: A meta-analysis was conducted according to the PRISMA statement...
February 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29433612/effect-of-electroconvulsive-therapy-on-hippocampal-and-amygdala-volumes-systematic-review-and-meta-analysis
#8
Akihiro Takamiya, Jun Ku Chung, Kuo-Ching Liang, Ariel Graff-Guerrero, Masaru Mimura, Taishiro Kishimoto
BACKGROUND: Electroconvulsive therapy (ECT) is one of the most effective treatments for depression, although the underlying mechanisms remain unclear. Animal studies have shown that electroconvulsive shock induced neuroplastic changes in the hippocampus. Aims To summarise volumetric magnetic resonance imaging studies investigating the effects of ECT on limbic brain structures. METHOD: A systematic review and meta-analysis was conducted to assess volumetric changes of each side of the hippocampus and amygdala before and after ECT...
January 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29432502/comparison-of-the-effect-of-intravenous-anesthetics-used-for-anesthesia-during-electroconvulsive-therapy-on-the-hemodynamic-safety-and-the-course-of-ect
#9
REVIEW
Rafał Wojdacz, Łukasz Święcicki, Anna Antosik-Wójcińska
Electroconvulsive therapy (ECT) is the treatment method widely used in psychiatric disorders such as depression, bipolar disorder, schizophrenia and schizoaffective disorder. The advantage of ECT is therapeutic response that occurs significantly earlier than during pharmacotherapy. Initially ECTwas used without anesthesia. Then, in the 1950s procedures with general anesthesia were introduced to reduce the complications that may occur during a seizure caused by ECT, such as broken bones, teeth, tendon rupture, muscle damage...
December 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29429092/use-of-cryo-em-to-study-the-structure-of-chemoreceptor-arrays-in-vivo
#10
Wen Yang, Ariane Briegel
Cryo-electron microscopy (cryo-EM) allows the imaging of intact macromolecular complexes in the context of whole cells. The biological samples for cryo-EM are kept in a near-native state by flash freezing, without the need for any additional sample preparation or fixation steps. Since transmission electron microscopy only generates 2D projections of the samples, the specimen has to be tilted in order to recover its 3D structural information. This is done by collecting images of the sample with various tilt angles in respect to the electron beam...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29428352/the-influence-of-the-anesthesia-to-stimulation-time-interval-on-seizure-quality-parameters-in-electroconvulsive-therapy
#11
A Jorgensen, S J Christensen, A E K Jensen, N V Olsen, M B Jorgensen
BACKGROUND: Electroconvulsive therapy (ECT) continues to be the most efficacious treatment for severe depression and other life-threatening acute psychiatric conditions. Treatment efficacy is dependent upon the induced seizure quality, which may be influenced by a range of treatment related factors. Recently, the time interval from anesthesia to the electrical stimulation (ASTI) has been suggested to be an important determinant of seizure quality. METHODS: We measured ASTI in 73 ECT sessions given to 22 individual patients, and analyzed its influence on five seizure quality parameters (EEG seizure time, power, coherence, postictal suppression, and peak heart rate)...
January 31, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29424757/survey-of-core-trainees-confidence-in-electroconvulsive-therapy
#12
Gillian Scott, David M Semple
OBJECTIVES: The objective of the survey was to assess confidence in electroconvulsive therapy (ECT) in core psychiatry trainees across Scotland, looking at both theoretical and practical aspects of ECT. METHODS: A link to a 14-item electronic questionnaire was distributed to core trainees via deanery administrators. Most questions were based on the Royal College of Psychiatry's ECT guidelines. RESULTS: A total of 85 responses were analyzed from trainees at all 3 levels of core training and from all health boards across Scotland...
February 7, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29419559/clinical-practice-recommendations-for-continuation-and-maintenance-electroconvulsive-therapy-for-depression-outcomes-from-a-review-of-the-evidence-and-a-consensus-workshop-held-in-australia-in-may-2017
#13
Shane P Gill, Charles H Kellner
OBJECTIVES: Continuation or maintenance electroconvulsive therapy (ECT) is often provided as a strategy for post-ECT relapse prevention. However, the evidence has been insufficient until recently to produce clear consensus on what best practice maintenance ECT (mECT) should be like in a real world ECT clinical service. The aims of this article are to help fill this gap and to provide a comprehensive set of practical, clinically-based recommendations for ECT clinicians and services. METHODS: A workshop was held at the Royal Australian and New Zealand College of Psychiatry Congress in Adelaide on April 30, 2017...
February 7, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29414386/electroconvulsive-therapy-among-elderly-patients-a-study-from-tertiary-care-centre-in-north-india
#14
Sandeep Grover, Ashirbad Satapathy, Subho Chakrabarti, Ajit Avasthi
OBJECTIVE: This retrospective study aimed to evaluate the effectiveness and safety of ECT among elderly patients receiving electroconvulsive therapy (ECT). METHODS: During the study period of January 2008 to May 2017, 151 patients aged ≥60 years received ECT and they formed the study sample. Data on patients aged 19 to 59 years for the period of 3 years (2014-2016) was also extracted for comparison purposes. RESULTS: The mean age of the elderly subjects was 65...
January 31, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29412850/electroconvulsive-therapy-in-geriatric-psychiatry-a-selective-review
#15
REVIEW
Justin P Meyer, Samantha K Swetter, Charles H Kellner
Electroconvulsive therapy (ECT) remains an important treatment of geriatric patients. ECT treats severe depression, mania, psychosis, catatonia, and comorbid depression and agitation in dementia. ECT also serves a crucial role in treating urgent illness requiring expedient recovery, such as catatonia, or in patients with severe suicidal ideation or intent. ECT is even more effective in the elderly than in mixed-age adult populations. ECT is a safe treatment option with few medical contraindications. Cognitive effects are largely transient, even in patients with preexisting cognitive impairment...
March 2018: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/29406761/-is-ethic-the-use-of-electroconvulsive-therapy
#16
Álvaro Romero-Tapia, Gilberto A Gamboa-Bernal
Electroconvulsive therapy (ECT) is an effective and safety medical procedure, broadly utilized in several countries for the treatment of multiple mental disorders, including major depressive disorder, which is a prevalent disease. However, due the records of their use, technical inappropriate of application, adverse effects and even cases of death associated to the procedure, it has been stigmatized, disused and considered unethical treatment. This paper reviews the main components of ECT and discuss in it is a bioethical treatment...
January 2018: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/29406294/evidence-corner-taking-itch-seriously
#17
Laura T Bolton
Dear Readers, Itching (pruritus) of a wound, scar, or dermatologic disorder can negatively impact a patient's quality of life, resulting in injurious scratching1 or impeded rehabilitation.2 Like pain, itch can cause the su erer to lose sleep and appetite or even consider suicide.3,4 Clinical measures of pruritus have proved reliable and valid in individuals with burn wounds, dermatologic conditions, or urticaria5-7 or resulting scars,2 allowing studies to clarify its impact on human experience and compare the e ects of interventions to reduce itching...
January 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29402858/skeletal-extracellular-matrix-supports-cardiac-differentiation-of-embryonic-stem-cells-a-potential-scaffold-for-engineered-cardiac-tissue
#18
Xian Hong, Yin Yuan, Xiaoxi Sun, Meiling Zhou, Guangyu Guo, Quan Zhang, Jürgen Hescheler, Jiaoya Xi
BACKGROUND/AIMS: Decellularized cardiac extracellular matrix (cECM) has been widely considered as an attractive scaffold for engineered cardiac tissue (ECT), however, its application is limited by immunogenicity and shortage of organ donation. Skeletal ECM (sECM) is readily available and shows similarities with cECM. Here we hypothesized that sECM might be an alternative scaffold for ECT strategies. METHODS: Murine ventricular tissue and anterior tibial muscles were sectioned into 300 mm-thick, and then cECM and sECM were acquired by pretreatment/SDS/TritonX-100 three-step-method...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29399543/the-effect-of-mesenchymal-stem-cell-derived-extracellular-vesicles-on-hematopoietic-stem-cells-fate
#19
REVIEW
Hamze Timari, Karim Shamsasenjan, Aliakbar Movassaghpour, Parvin Akbarzadehlaleh, Davod Pashoutan Sarvar, Sara Aqmasheh
Hematopoietic stem cells (HSCs) are multipotent stem cells, with self-renewal ability as well as ability to generate all blood cells. Mesenchymal stem cells (MSCs) are multipotent stem cells, with self-renewal ability, and capable of differentiating into a variety of cell types. MSCs have supporting effects on hematopoiesis; through direct intercellular communications as well as secreting cytokines, chemokines, and extracellular vesicles (EVs). Recent investigations demonstrated that some biological functions and effects of MSCs are mediated by their EVs...
December 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29398916/systematic-review-of-catatonia-treatment
#20
REVIEW
Anne Cm Pelzer, Frank Mma van der Heijden, Erik den Boer
Objective: To investigate the evidence-based treatment of catatonia in adults. The secondary aim is to develop a treatment protocol. Materials and methods: A systematic review of published treatment articles (case series, cohort or randomized controlled studies) which examined the effects of particular interventions for catatonia and/or catatonic symptoms in adult populations and used valid outcome measures was performed. The articles for this review were selected by searching the electronic databases of the Cochrane Library, MEDLINE, EMBASE and PSYCHINFO...
2018: Neuropsychiatric Disease and Treatment
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