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https://www.readbyqxmd.com/read/29053896/quality-and-reporting-of-guidelines-on-the-diagnosis-and-management-of-dystonia
#1
Gertrúd Tamás, Catarina Abrantes, Anabela Valadas, Péter Radics, Alberto Albanese, Marina A J Tijssen, Joaquim J Ferreira
BACKGROUND: The quality of clinical practice guidelines on dystonia has not yet been assessed. Our aim was to appraise the methodological quality of guidelines worldwide and analyze the consistency of their recommendations. METHODS: We searched for clinical practice guidelines on dystonia diagnosis/treatment in the National Guideline Clearinghouse, PubMed, National Institute for Health and Care Excellence, Guidelines International Network and Web of Science databases...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053876/blood-hematological-and-biochemical-constituents-antioxidant-enzymes-immunity-and-lymphoid-organs-of-broiler-chicks-supplemented-with-propolis-bee-pollen-and-mannan-oligosaccharides-continuously-or-intermittently
#2
Y A Attia, H Al-Khalaifah, M S Ibrahim, A E Abd Al-Hamid, M A Al-Harthi, A El-Naggar
This study investigate the effect of bee pollen (BP) and/or propolis (Pro) as an alternative to Mannan oligosaccharides (Bio-MOS, a hydrolyzed yeast with natural and artificial flavors Alltech Inc) when given continuously or intermittently on antioxidant enzymes, immunity, weight and morphology of lymphoid organs of broilers. Thus, 324 unsexed one-day-old Arbor Acres broilers were randomly distributed into nine treatment groups, each replicated 6 times of 6 birds per replicate. The chicks were kept in wire cages and fed the same basal diet and were submitted to the following treatments: control without supplementation (control) or supplemented with BP at 300 mg, Pro at 300 mg, BP+Pro at 300 mg each and Bio-MOS at 0...
October 10, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053666/experimental-implementation-of-a-new-composite-fabrication-method-exposing-bare-fibers-on-the-composite-surface-by-the-soft-layer-method
#3
Dongyoung Lee, Dai Gil Lee, Jun Woo Lim
The bipolar plate is a key component in proton exchange membrane fuel cells (PEMFCs) and vanadium redox flow batteries (VRFBs). It is a multi-functional component that should have high electrical conductivity, high mechanical properties, and high productivity. In this regard, a carbon fiber/epoxy resin composite can be an ideal material to replace the conventional graphite bipolar plate, which often leads to the catastrophic failure of the entire system because of its inherent brittleness. Though the carbon/epoxy composite has high mechanical properties and is easy to manufacture, the electrical conductivity in the through-thickness direction is poor because of the resin-rich layer that forms on its surface...
October 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053537/thermal-ultra-short-photodynamic-therapy-heating-fibroblasts-during-sub-30-minute-incubation-of-5-aminolevulinic-acid-increases-photodynamic-therapy-induced-cell-death
#4
Eugene Koo, Evan Austin, Andrew Mamalis, Jared Jagdeo
BACKGROUND: Actinic keratoses (AKs) prevalence was estimated at 39.5 million Americans in 2004, and the cost to treat AKs that year was approximately 1 billion dollars. Photodynamic therapy (PDT) is an FDA-approved therapy for the treatment of AK. Recent studies have focused on reducing PDT treatment time while maintaining efficacy. OBJECTIVE: To investigate the use of thermal modulation to improve the efficacy of ultra short aminolevulinic acid (ALA) incubation PDT...
October 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29053379/the-impact-of-cost-conversations-on-the-patient-physician-relationship
#5
Danielle J Brick, Karen A Scherr, Peter A Ubel
Previous research has suggested that fear of harm to the patient-physician relationship is an important barrier to conversations about cost of care. However, few experimental studies have investigated the effects of cost of care conversations on the patient-physician relationship, particularly from the patient's perspective. In the current research, we take an experimental approach to investigate patients' attitudes and preferences for a hypothetical physician who discusses cost versus one who does not. Across three studies, using data from both the general population and cancer patients, we find that people prefer a hypothetical physician who discusses cost over one who does not (Pilot Study, Studies 1 and 2)...
October 20, 2017: Health Communication
https://www.readbyqxmd.com/read/29053157/current-applications-of-multiparameter-flow-cytometry-in-plasma-cell-disorders
#6
REVIEW
T Jelinek, R Bezdekova, M Zatopkova, L Burgos, M Simicek, T Sevcikova, B Paiva, R Hajek
Multiparameter flow cytometry (MFC) has become standard in the management of patients with plasma cell (PC) dyscrasias, and could be considered mandatory in specific areas of routine clinical practice. It plays a significant role during the differential diagnostic work-up because of its fast and conclusive readout of PC clonality, and simultaneously provides prognostic information in most monoclonal gammopathies. Recent advances in the treatment and outcomes of multiple myeloma led to the implementation of new response criteria, including minimal residual disease (MRD) status as one of the most relevant clinical endpoints with the potential to act as surrogate for survival...
October 20, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/29052818/out-of-pocket-cost-is-a-barrier-to-therapeutic-drug-monitoring-in-inflammatory-bowel-disease
#7
James P Campbell, Erin Burton, Shelly Wymer, Michael Shaw, Byron P Vaughn
BACKGROUND: Therapeutic drug monitoring (TDM) is increasingly performed to optimize biologic therapy in inflammatory bowel disease (IBD). However, patients and physicians may be reluctant to perform TDM due to concerns related to potential out-of-pocket costs. AIMS: The aim of this study was to evaluate patient understanding and attitudes toward TDM in different clinical scenarios with and without potential out-of-pocket costs. METHODS: Adult IBD patients at a tertiary gastroenterology clinic were anonymously surveyed from March to September 2016 to assess their understanding of and willingness to undergo TDM in a variety of clinical scenarios, both with and without a potential out-of-pocket cost...
October 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29052765/assessment-of-different-systems-for-the-production-of-aldonic-acids-and-sorbitol-by-calcium-alginate-immobilized-zymomonas-mobilis-cells
#8
Analia Borges Folle, Victoria Maria Baschera, Luiza Tessaro Vivan, Sabrina Carra, Tomás Augusto Polidoro, Eloane Malvessi, Mauricio Moura da Silveira
Equimolar amounts of lactobionic acid and sorbitol may be obtained in a reaction catalyzed by the enzymes glucose-fructose oxidoreductase and glucono-δ-lactonase, which are found in the periplasm of Zymomonas mobilis. These reactions are generally conducted using immobilized bacterial cells, and the cell treatment and immobilization steps are costly and time-consuming. This study evaluated alternatives to simplify the preparation of calcium alginate-immobilized biocatalyst and its application in different operation modes and types of reactors...
October 20, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29052674/egfr-targeting-plga-peg-nanoparticles-as-a-curcumin-delivery-system-for-breast-cancer-therapy
#9
Hua Jin, Jiang Pi, Yue Zhao, Jinhuan Jiang, Ting Li, Xueyi Zeng, Peihui Yang, Colin E Evans, Jiye Cai
Poor bioavailability and non-specificity of chemotherapeutic agents are major challenges in breast cancer treatment. Antibodies and small molecules that block cell signaling pathways have shown promise in the clinic, but their application is also limited by the high costs and treatment dosages required. Novel therapies that aim to rapidly and specifically target malignant cells with long-lasting impact in the tumor microenvironment may ultimately improve clinical outcome in cancer patients. Here, we demonstrate that epidermal growth factor receptor (EGFR)-targeting GE11 peptides conjugated with PEGylated polylactic-co-glycolic acid (PLGA) nanoparticles can be used to effectively deliver an anti-cancer agent, curcumin, into EGFR-expressing MCF-7 cells in vitro and in vivo...
October 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/29052566/analysis-on-inpatient-health-expenditures-of-renal-cell-carcinoma-in-a-grade-a-tertiary-hospital-in-beijing
#10
Xin Liu, Yong-Hui Mao, Xue-Mei He, Yan-Jing Zhang, Ying Sun
BACKGROUND: Renal cell carcinoma (RCC) is the most common type of malignant renal tumors with a growing incidence in the recent years. This study aimed to investigate the influencing factors and variation trend of hospitalization expenditures among RCC patients in a single-centered hospital in Beijing during 5 consecutive years and to find the major cost items and fluctuation tendency of inpatient medical expenditures. METHODS: The information of medical expenditures among RCC patients in a Grade-A tertiary hospital during the years 2012-2016 was investigated to find the main cost items and changes affecting the medical cost structure...
October 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29052534/specialist-advice-may-improve-patient-selection-for-decompression-therapy-following-diving-accidents-a-retrospective-observational-study
#11
Daniel Steffensmeier, Roland Albrecht, Jürg Wendling, Roger Melliger, Donat R Spahn, Philipp Stein, Christophe Wyss
BACKGROUND: Even in a landlocked country like Switzerland recreational diving is becoming more and more popular. Smaller lakes in the Alps are located at an altitude of 2500 m above sea level. The incidence of diving accidents among all helicopter emergency service missions and the consecutive medical knowledge about decompression injuries is low. Thus, a collaboration between the Swiss Air-Ambulance (Rega) and the divers alert network (DAN) was initiated to improve patient treatment and identification of decompression injury and necessity of hyperbaric oxygen therapy (HBO)...
October 19, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29052529/evaluating-a-multi-component-community-based-program-to-improve-adherence-and-retention-in-care-among-adolescents-living-with-hiv-in-zimbabwe-study-protocol-for-a-cluster-randomized-controlled-trial
#12
Webster Mavhu, Nicola Willis, Juliet Mufuka, Collin Mangenah, Kudzanayi Mvududu, Sarah Bernays, Walter Mangezi, Tsitsi Apollo, Ricardo Araya, Helen A Weiss, Frances M Cowan
BACKGROUND: World Health Organization (WHO) adolescent HIV-testing and treatment guidelines recommend community-based interventions to support antiretroviral therapy (ART) adherence and retention in care, while acknowledging that the evidence to support this recommendation is weak. This cluster randomized controlled trial aims to evaluate the effectiveness and cost-effectiveness of a psychosocial, community-based intervention on HIV-related and psychosocial outcomes. METHODS/DESIGN: We are conducting the trial in two districts...
October 20, 2017: Trials
https://www.readbyqxmd.com/read/29052503/intensive-follow-up-for-women-with-breast-cancer-review-of-clinical-economic-and-patient-s-preference-domains-through-evidence-to-decision-framework
#13
Alessandra Lafranconi, Liisa Pylkkänen, Silvia Deandrea, Anke Bramesfeld, Donata Lerda, Luciana Neamțiu, Zuleika Saz-Parkinson, Margarita Posso, David Rigau, Ivan Sola, Pablo Alonso-Coello, Maria José Martinez-Zapata
BACKGROUND: Women treated for breast cancer are followed-up for monitoring of treatment effectiveness and for detecting recurrences at an early stage. The type of follow-up received may affect women's reassurance and impact on their quality of life. Anxiety and depression among women with breast cancer has been described, but little is known about how the intensity of the follow-up can affect women's psychological status. This study was undertaken to evaluate the effects of intensive vs...
October 19, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29052184/bisulfite-sequencing-using-small-dna-amounts
#14
Susanne Edelmann, Stefan Scholten
Bisulfite sequencing (BS-seq) enables the detection of DNA methylation at cytosine residues (5mC) at single-nucleotide resolution. For many applications, a limiting factor of conventional BS-seq protocols is the high amount of DNA required, since the treatment with bisulfite causes severe DNA fragmentation. Here, we describe a post-bisulfite tagging method that accounts for this problem. Illumina-compatible BS-seq libraries can be obtained from as little as five single haploid maize cells, enabling whole genome BS-seq (WGBS) for the generation of genome-wide, cell-type specific DNA methylation profiles...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29052069/robotic-single-site-versus-multiport-laparoscopic-cholecystectomy-a-case-matched-analysis-of-short-and-long-term-costs
#15
Monika E Hagen, Alexandre Balaphas, Michele Podetta, Peter Rohner, Minoa K Jung, Nicolas C Buchs, Leo Buehler, Jona M Mendoza, Philippe Morel
BACKGROUND: Multiport laparoscopy is the gold-standard approach for cholecystectomy, and single-port laparoscopy has been developed to further reduce its invasiveness. A specific robotic single-port platform (da Vinci single-site, Intuitive Surgical Inc., Sunnyvale, CA, USA) has been released in 2011, which could technically facilitate single-site cholecystectomy. Current data show its feasibility; however, detailed short- and long-term analyses of costs and comparisons relative to multiport laparoscopy are not available to date...
October 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29052063/endoscopic-treatment-of-leaks-after-laparoscopic-sleeve-gastrectomy-using-mega-esophageal-covered-stents
#16
Tomasz Klimczak, Jerzy Klimczak, Tomasz Szewczyk, Przemysław Janczak, Piotr Jurałowicz
BACKGROUND: Sleeve gastrectomy has become one of the main bariatric procedures over the last few years. This can be explained by the relative simplicity and high effectiveness of this method. Yet, it causes complications as any other method. Staple line leaks are the most frequent ones. According to different sources, this complication may occur with 0-7% frequency. Until 2013, surgery was the only effective treatment method for this complication. However, reoperations considerably increased treatment cost and patient morbidity...
October 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29051994/telotristat-ethyl-proof-of-principle-and-the-first-oral-agent-in-the-management-of-well-differentiated-metastatic-neuroendocrine-tumor-and-carcinoid-syndrome-diarrhea
#17
REVIEW
Muhammad Masab, Muhammad Wasif Saif
INTRODUCTION: Metastatic neuroendocrine tumors (NETs) are associated with carcinoid syndrome that is typically characterized by diarrhea, cutaneous flushing and bronchospasm. Treatment with somatostatin analogues (SSA) improves the symptom burden but a significant proportion of patients stop responding to SSA therapy eventually. Novel agents with the potential to effectively control the symptoms are urgently needed. METHODS: This article reviews an in-depth analysis of the phase I-III clinical trials determining the clinical rationale for the use of tryptophan hydroxylase inhibitor, telotristat ethyl in patients with well-differentiated metastatic NETs and uncontrolled carcinoid syndrome...
October 19, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29051826/apparent-and-standardized-ileal-nutrient-digestibility-of-broiler-diets-containing-varying-levels-of-raw-full-fat-soybean-and-microbial-protease
#18
Mammo M Erdaw, Rider A Perez-Maldonado, Paul A Iji
BACKGROUND: Although soybean meal (SBM) is excellent source of protein in diets for poultry, it is sometimes inaccessible, costly and fluctuates in supply. The SBM can partially be replaced by full-fat SBM, but the meals prepared from raw full-fat soybean contain antinutritional factors. To avoid the risk of antinutritional factors, heat treatment is always advisable, but either excessive or under heating the soybean could negatively affect the quality. However, the potential for further improvement of SBM by supplementing with microbial enzymes has been suggested by many researchers...
2017: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/29051816/eptifibatide-is-associated-with-significant-cost-savings-and-similar-clinical-outcomes-to-abciximab-when-used-during-primary-percutaneous-coronary-intervention-for-st-elevation-myocardial-infarction-an-observational-cohort-study-of-3863-patients
#19
K S Rathod, S Antoniou, P Avari, N Ding, P Wright, C Knight, A K Jain, A Mathur, E J Smith, R Weerackody, A Wragg, D A Jones
INTRODUCTION: Glycoprotein IIb/IIIa inhibitors are recommended by guidelines in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. There are few studies directly comparing these agents. The aim of this study was to assess whether eptifibatide is a safe and cost-effective alternative to abciximab in the treatment of primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. METHODS: This was an observational cohort study of 3863 patients who received a GPIIb/IIIa inhibitor whilst undergoing primary percutaneous coronary intervention from 2007 to 2014...
January 2017: JRSM Cardiovascular Disease
https://www.readbyqxmd.com/read/29051145/a-discrete-choice-study-of-patient-preferences-for-dialysis-modalities
#20
Rachael C Walker, Rachael L Morton, Suetonia C Palmer, Mark R Marshall, Allison Tong, Kirsten Howard
BACKGROUND AND OBJECTIVES: Improved knowledge about factors that influence patient choices when considering dialysis modality could facilitate health care interventions to increase rates of home dialysis. We aimed to quantify the attributes of dialysis care and the tradeoffs that patients consider when making decisions about dialysis modalities. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a prospective, discrete choice experiment survey with random parameter logit analysis to quantify preferences and tradeoffs for attributes of dialysis treatment in 143 adult patients with CKD expected to require RRT within 12 months (predialysis)...
October 19, 2017: Clinical Journal of the American Society of Nephrology: CJASN
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