keyword
https://read.qxmd.com/read/38508276/cadmium-immobilization-in-soil-using-phosphate-modified-biochar-derived-from-wheat-straw
#1
JOURNAL ARTICLE
Xiaojing Yu, Xiaorou Wang, Mei Sun, He Liu, Dongmei Liu, Jiulan Dai
The phosphate-modified biochar (BC) immobilizes cadmium (Cd), yet little is known about how phosphate species affect Cd detoxification in contaminated soils. We developed phosphate-modified biochar through the pyrolysis of wheat straw impregnated with three types of phosphate: mono‑potassium phosphate (MKP), dipotassium hydrogen phosphate (DKP), and tripotassium phosphate (TKP). The Cd adsorption mechanism of modified biochar was investigated by biochar characterization, adsorption performance evaluation, and soil incubation tests...
March 18, 2024: Science of the Total Environment
https://read.qxmd.com/read/38439200/the-glucocorticoid-dexamethasone-alleviates-allergic-inflammation-through-a-mitogen-activated-protein-kinase-phosphatase-1-dependent-mechanism-in-mice
#2
JOURNAL ARTICLE
Tiina Lehtola, Elina Nummenmaa, Riina Nieminen, Mari Hämäläinen, Katriina Vuolteenaho, Eeva Moilanen
Glucocorticoids are widely used in the treatment of allergic and inflammatory diseases. Glucocorticoids have a widespread action on gene expression resulting in their pharmacological actions and also an array of adverse effects which limit their clinical use. It remains, however, to be studied which target gene effects are essential for the anti-allergic activity of glucocorticoids. Mitogen-activated protein kinase phosphatase-1 (MKP-1) inhibits proinflammatory signalling by suppressing the activity of mitogen activated protein kinase (MAP kinase) pathways...
March 4, 2024: Basic & Clinical Pharmacology & Toxicology
https://read.qxmd.com/read/38428352/effect-of-rna-interference-with-hif-1%C3%AE-on-the-growth-of-pulmonary-artery-endothelial-cells-in-broiler-chickens
#3
JOURNAL ARTICLE
Wen Peng, Weile Fang, Xiaona Gao, Xiaoquan Guo, Guyue Li, Fengping Guo, Guoliang Hu, Yu Zhuang, Lin Li, Chenxi Jiang, Ping Liu
Pulmonary artery remodeling is a characteristic feature of broiler ascites syndrome (BAS). Pulmonary artery endothelial cells (PAECs) regulated by HIF-1α play a critical role in pulmonary artery remodeling, but the underlying mechanisms of HIF-1α in BAS remain unclear. In this experiment, primary PAECs were cultured in vitro and were identified by coagulation factor VIII. After hypoxia and RNA interference, the mRNA and protein expression levels of HIF-1α and VEGF were determined by qPCR and Western blotting...
December 18, 2023: Poultry Science
https://read.qxmd.com/read/38424085/down-regulation-of-mkp-1-in-hippocampus-protects-against-stress-induced-depression-like-behaviors-and-neuroinflammation
#4
JOURNAL ARTICLE
Mengjun Geng, Qiujing Shao, Jiacheng Fu, Jingyang Gu, Laipeng Feng, Liqin Zhao, Cong Liu, Junlin Mu, Xiaoli Zhang, Mingjun Zhao, Xinsheng Guo, Cai Song, Yan Li, Huiying Wang, Changhong Wang
Chronic stress is the primary environmental risk factor for major depressive disorder (MDD), and there is compelling evidence that neuroinflammation is the major pathomechanism linking chronic stress to MDD. Mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) is a negative regulator of MAPK signaling pathways involved in cellular stress responses, survival, and neuroinflammation. We examined the possible contributions of MKP-1 to stress-induced MDD by comparing depression-like behaviors (anhedonia, motor retardation, behavioral despair), neuroinflammatory marker expression, and MAPK signaling pathways among rats exposed to chronic unpredictable mild stress (CUMS), overexpressing MKP-1 in the hippocampus, and CUMS-exposed rats underexpressing MKP-1 in the hippocampus...
March 1, 2024: Translational Psychiatry
https://read.qxmd.com/read/38359646/sars-cov-2-spike-protein-receptor-binding-domain-promotes-il-6-and-il-8-release-via-atp-p2y-2-and-erk1-2-signaling-pathways-in-human-bronchial-epithelia
#5
JOURNAL ARTICLE
Rui-Gang Zhang, Xing-Jian Liu, Yu-Ling Guo, Chun-Ling Chen
The spike protein of SARS-CoV-2 as well as its receptor binding domain (RBD) has been demonstrated to be capable of activating the release of pro-inflammatory mediators in endothelial cells and immune cells such as monocytes. However, the effects of spike protein or its RBD on airway epithelial cells and mechanisms underlying these effects have not been adequately characterized. Here, we show that the RBD of spike protein alone can induce bronchial epithelial inflammation in a manner of ATP/P2Y2 dependence...
February 14, 2024: Molecular Immunology
https://read.qxmd.com/read/38348341/scoparone-attenuates-pd-l1-expression-in-human-breast-cancer-cells-by-mkp-3-upregulation
#6
JOURNAL ARTICLE
Seung-Woo Kim, Chan Woo Kim, Hong Seok Kim
Breast cancer is a frequently occurring malignant tumor that is one of the leading causes of cancer-related deaths in women worldwide. Monoclonal antibodies that block programed cell death 1 (PD-1)/programed cell death ligand 1 (PD-L1) - a typical immune checkpoint - are currently the recommended standard therapies for many advanced and metastatic tumors such as triple-negative breast cancer. However, some patients develop drug resistance, leading to unfavorable treatment outcomes. Therefore, other approaches are required for anticancer treatments, such as downregulation of PD-L1 expression and promotion of degradation of PD-L1...
2024: Animal Cells and Systems
https://read.qxmd.com/read/38322333/-mir-429-3p-mediates-memory-decline-by-targeting-mkp-1-to-reduce-surface-glua1-containing-ampa-receptors-in-a-mouse-model-of-alzheimer-s-disease
#7
JOURNAL ARTICLE
Man Luo, Yayan Pang, Junjie Li, Lilin Yi, Bin Wu, Qiuyun Tian, Yan He, Maoju Wang, Lei Xia, Guiqiong He, Weihong Song, Yehong Du, Zhifang Dong
Alzheimer's disease (AD) is a leading cause of dementia in the elderly. Mitogen-activated protein kinase phosphatase 1 (MKP-1) plays a neuroprotective role in AD. However, the molecular mechanisms underlying the effects of MKP-1 on AD have not been extensively studied. MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level, thereby repressing mRNA translation. Here, we reported that the microRNA-429-3p ( miR-429-3p ) was significantly increased in the brain of APP23/PS45 AD model mice and N2AAPP AD model cells...
February 2024: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/38305849/loss-of-mitogen-activated-protein-kinase-phosphate-5-aggravates-islet-dysfunction-in-mice-with-type-1-and-type-2-diabetes
#8
JOURNAL ARTICLE
Tongjian Zhao, Yafei Tian, Jianan Zhao, Dandan Sun, Yongjun Ma, Wei Wang, Weiqun Yan, Ping Jiao, Jie Ma
Impaired functionality and loss of islet β-cells are the primary abnormalities underlying the pathogenesis of both type 1 and 2 diabetes (T1DM and T2DM). However, specific therapeutic and preventive mechanisms underlying these conditions remain unclear. Mitogen-activated protein kinase phosphatase-5 (MKP-5) has been implicated in carcinogenesis, lipid metabolism regulation, and immune cell activation. In a previous study, we demonstrated the involvement of exogenous MKP-5 in the regulation of obesity-induced T2DM...
February 15, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38299032/mif-modulates-p38-erk-phosphorylation-via-mkp-1-induction-in-sarcoidosis
#9
JOURNAL ARTICLE
Jaya Talreja, Changya Peng, Lobelia Samavati
Macrophage migration inhibitory factor (MIF) is a versatile cytokine that influences a variety of cellular processes important for immune regulation and tissue homeostasis. Sarcoidosis is a granulomatous disease characterized by extensive local inflammation and increased T helper cell mediated cytokines. We have shown that MIF has a modulatory role in cytokine networks in sarcoidosis. We investigated the effect of exogenous MIF on sarcoidosis alveolar macrophages (AMs), CD14+ monocytes and peripheral blood mononuclear cells (PBMCs)...
January 19, 2024: IScience
https://read.qxmd.com/read/38192141/dexamethasone-suppresses-il-33-exacerbated-malignant-phenotype-of-u87mg-glioblastoma-cells-via-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways
#10
JOURNAL ARTICLE
Jie Ai, Yinhua Weng, Liyan Jiang, Chao Liu, Hongbo Liu, Huoying Chen
BACKGROUND: Interleukin (IL)-33 is highly expressed in glioblastoma (GBM) and promotes tumor progression. Targeting IL-33 may be an effective strategy for the treatment of GBM. Dexamethasone (DEX) is a controversial drug routinely used clinically in GBM therapy. Whether DEX has an effect on IL-33 is unknown. This study aimed to investigate the effect of DEX on IL-33 and the molecular mechanisms involved. METHODS: U87MG cells were induced by tumor necrosis factor (TNF)-α to express IL-33 and then treated with DEX...
January 8, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38135253/whole-blood-coagulation-in-an-ex-vivo-thrombus-is-sufficient-to-induce-clot-neutrophils-to-adopt-a-myeloid-derived-suppressor-cell-signature-and-shed-soluble-lox-1
#11
JOURNAL ARTICLE
Julia Leonard, David Kepplinger, Virginia Espina, Pat Gillevet, Yunbo Ke, Konstantin G Birukov, Allan Doctor, Caroline D Hoemann
BACKGROUND: Blood clots are living tissues that release inflammatory mediators including IL-8/CXCL8 and MCP-1/CCL2. A deeper understanding of blood clots is needed to develop new therapies for pro-thrombotic disease states and regenerative medicine. OBJECTIVES: Identify a common transcriptional shift in cultured blood clot leukocytes. METHODS: Differential gene expression of whole blood and cultured clots (4h 37°C) was assessed by RNA sequencing (RNAseq), RT-PCR, proteomics, and histology (23 diverse healthy human donors)...
December 20, 2023: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/38104367/panax-notoginseng-saponin-r1-improves-glucocorticoid-inhibited-airway-epithelium-repair-via-glucocorticoid-receptor-%C3%AE
#12
JOURNAL ARTICLE
Lili Yang, Maozhu Xu, Linghuan Zhang, Mingxiang Zhang, Wenjie Wu, Zhengxiu Luo, Daiyin Tian, Zhou Fu, Wenjing Zou
BACKGROUND: Panax notoginseng saponin R1(PNS-R1), derived from Panax notoginseng roots, promotes wound repair, whereas glucocorticoids can inhibit the repair of airway epithelial damage in asthma. OBJECTIVE: This study investigated whether PNS-R1 counteracts the inhibitory effects of glucocorticoids on the repair of airway epithelial damage in asthma. METHODS: In vivo, female C57BL/6 mice were sensitized, challenged with house dust mites (HDM), and treated with dexamethasone, PNS-R1, and/or adenovirus GRβ-shRNA...
December 16, 2023: International Immunopharmacology
https://read.qxmd.com/read/38061313/macrophage-restricted-overexpression-of-glutaredoxin-1-protects-against-atherosclerosis-by-preventing-nutrient-stress-induced-macrophage-dysfunction-and-reprogramming
#13
JOURNAL ARTICLE
Yong Joo Ahn, Luxi Wang, Seonwook Kim, Matthew R Eber, Alessandro G Salerno, Reto Asmis
BACKGROUND AND AIMS: Deficiency in the thiol transferase glutaredoxin 1 (Grx1) in aging mice promotes, in a sexually dimorphic manner, dysregulation of macrophages and atherogenesis. However, the underlying mechanisms are not known. Here we tested the hypothesis that macrophage-restricted overexpression of Grx1 protects atherosclerosis-prone mice against macrophage reprogramming and dysfunction induced by a high-calorie diet (HCD) and thereby reduces the severity of atherosclerosis. METHODS: We generated lentiviral vectors carrying cluster of differentiation 68 (CD68) promoter-driven enhanced green fluorescent protein (EGFP) or Grx1 constructs and conducted bone marrow (BM) transplantation studies to overexpress Grx1 in a macrophage-specific manner in male and female atherosclerosis-prone LDLR-/- mice, and fed these mice a HCD to induce atherogenesis...
November 22, 2023: Atherosclerosis
https://read.qxmd.com/read/37984224/heat-shock-induces-hur-dependent-mkp-1-posttranslational-regulation-through-the-p38-mapk-signaling-cascade
#14
JOURNAL ARTICLE
Xiao-Juan Ma, Zhan Sun, Yi-Ping Wang, Xue-Ping Yao, Ting-Ting Luo, Ya-Li Bao, Dina Ainiwaer, Tian Zhang, Hengyi Zhu, Yan Zhang, Fei-Ming Hu, Wen-Yan Yu
Previous studies demonstrated that phosphatases play a pivotal role in modulating inflammation-associated signal transduction, particularly in the context of heat shock, where Mitogen-Activated Protein Kinase Phosphatase-1 (MKP-1) appears to have a central role. Recently, Human Antigen R (HuR) has also been identified as a factor that enhances stress-response protein MKP-1 levels. Consequently, we have directed our interest towards elucidating the mechanisms by which heat shock induces MKP-1 mRNA stabilization, dependent on HuR via the p38 MAPK Signaling Cascade...
November 18, 2023: Tissue & Cell
https://read.qxmd.com/read/37958545/acute-endoplasmic-reticulum-stress-suppresses-hepatic-gluconeogenesis-by-stimulating-mapk-phosphatase-3-degradation
#15
JOURNAL ARTICLE
Xiaohua Huang, Heng Zhu, Wei Lu, Lei Cao, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Yong Zhuo, Lun Hua, Xuemei Jiang, Mengmeng Sun, De Wu, Bin Feng
Drug-induced liver injury (DILI) is a widespread and harmful disease, and is closely linked to acute endoplasmic reticulum (ER) stress. Previous reports have shown that acute ER stress can suppress hepatic gluconeogenesis and even leads to hypoglycemia. However, the mechanism is still unclear. MAPK phosphatase 3 (MKP-3) is a positive regulator for gluconeogenesis. Thus, this study was conducted to investigate the role of MKP-3 in the suppression of gluconeogenesis by acute ER stress, as well as the regulatory role of acute ER stress on the expression of MKP-3...
October 25, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37927131/extracellular-vesicles-released-by-lactobacillus-paracasei-mitigate-stress-induced-transcriptional-changes-and-depression-like-behavior-in-mice
#16
JOURNAL ARTICLE
Hyejin Kwon, Eun-Hwa Lee, Juli Choi, Jin-Young Park, Yoon-Keun Kim, Pyung-Lim Han
Various probiotic strains have been reported to affect emotional behavior. However, the underlying mechanisms by which specific probiotic strains change brain function are not clearly understood. Here, we report that extracellular vesicles derived from Lactobacillus paracasei ( Lpc -EV) have an ability to produce genome-wide changes against glucocorticoid (GC)-induced transcriptional responses in HT22 hippocampal neuronal cells. Genome-wide analysis using microarray assay followed by Rank-Rank Hypergeometric Overlap (RRHO) method leads to identify the top 20%-ranked 1,754 genes up- or down-regulated following GC treatment and their altered expressions are reversed by Lpc -EV in HT22 cells...
October 31, 2023: Experimental Neurobiology
https://read.qxmd.com/read/37886801/intraperitoneal-administration-of-mouse-kisspeptin-10-to-mice-during-estrus-stage-induces-pseudopregnancy
#17
JOURNAL ARTICLE
Daisuke Mashiko, Mikiko Tokoro, Tatsuma Yao, Kazuo Yamagata
A simple method for producing pseudopregnant mice supports pup production. In this study, pregnant ICR were obtained mice without mating with vasectomized mice via administration of mouse Kisspeptin-10 (mKp-10) and transferring blastocysts to the uterus. Blastocyst transfer after mKp-10 administration to mice with gapping and reddish pink vagina resulted in 65.2% (15/23) pregnancies, and 39.1% (34/87) of the transferred blastocysts showed full-term growth. Vaginal smears were observed for accurate estrus cycle determination, and subsequent administration of mKp10 to mice during the estrus stage and blastocyst transfer resulted in 95...
October 27, 2023: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://read.qxmd.com/read/37878335/the-ketone-body-%C3%AE-hydroxybutyrate-shifts-microglial-metabolism-and-suppresses-amyloid-%C3%AE-oligomer-induced-inflammation-in-human-microglia
#18
JOURNAL ARTICLE
Lee-Way Jin, Jacopo Di Lucente, Ulises Ruiz Mendiola, Nopparat Suthprasertporn, Alexey Tomilov, Gino Cortopassi, Kyoungmi Kim, Jon J Ramsey, Izumi Maezawa
Fatty acids are metabolized by β-oxidation within the "mitochondrial ketogenic pathway" (MKP) to generate β-hydroxybutyrate (BHB), a ketone body. BHB can be generated by most cells but largely by hepatocytes following exercise, fasting, or ketogenic diet consumption. BHB has been shown to modulate systemic and brain inflammation; however, its direct effects on microglia have been little studied. We investigated the impact of BHB on Aβ oligomer (AβO)-stimulated human iPS-derived microglia (hiMG), a model relevant to the pathogenesis of Alzheimer's disease (AD)...
November 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/37868732/retracted-mkp-1-overexpression-reduces-postischemic-myocardial-damage-through-attenuation-of-er-stress-and-mitochondrial-damage
#19
Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2021/8905578.].
2023: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/37776398/dusp1-mkp-1-represents-another-piece-in-the-p2x7r-intracellular-signaling-puzzle-in-cerebellar-cells-our-last-journey-with-m%C3%A2%C2%AA-teresa-along-the-purinergic-pathways-of-eden
#20
JOURNAL ARTICLE
Juan Carlos Gil-Redondo, María José Queipo, Yaiza Trueba, Celia Llorente-Sáez, Julia Serrano, Felipe Ortega, Rosa Gómez-Villafuertes, Raquel Pérez-Sen, Esmerilda G Delicado
The P2X7 receptor (P2X7R) stands out within the purinergic family as it has exclusive pharmacological and regulatory features, and it fulfills distinct roles depending on the type of stimulation and cellular environment. Tonic activation of P2X7R promotes cell proliferation, whereas sustained activation is associated with cell death. Yet strikingly, prolonged P2X7R activation in rat cerebellar granule neurons and astrocytes does not affect cell survival. The intracellular pathways activated by P2X7Rs involve proteins like MAPKs, ERK1/2 and p38, and interactions with growth factor receptors could explain their behavior in populations of rat cerebellar cells...
September 30, 2023: Purinergic Signalling
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