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G6PD oxidative stress

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https://www.readbyqxmd.com/read/29626298/l-cysteine-in-vitro-can-restore-cellular-glutathione-and-inhibits-the-expression-of-cell-adhesion-molecules-in-g6pd-deficient-monocytes
#1
Rajesh Parsanathan, Sushil K Jain
L-Cysteine is a precursor of glutathione (GSH), a potent physiological antioxidant. Excess glucose-6-phosphate dehydrogenase (G6PD) deficiency in African Americans and low levels of L-cysteine diet in Hispanics can contributes to GSH deficiency and oxidative stress. Oxidative stress and monocyte adhesion was considered to be an initial event in the progression of vascular dysfunction and atherosclerosis. However, no previous study has investigated the contribution of GSH/G6PD deficiency to the expression of monocyte adhesion molecules...
April 6, 2018: Amino Acids
https://www.readbyqxmd.com/read/29604498/oxidative-stress-and-mitochondrial-dysfunction-mediated-cd-induced-hepatic-lipid-accumulation-in-zebrafish-danio-rerio
#2
Ya-Xiong Pan, Zhi Luo, Mei-Qing Zhuo, Chuan-Chuan Wei, Guang-Hui Chen, Yu-Feng Song
The present study was performed to determine the effect of waterborne CdCl2 exposure influencing lipid deposition and metabolism, oxidative stress and mitochondrial dysfunction, and explore the underlying molecular mechanism of cadmium (Cd)-induced disorder of hepatic lipid metabolism in fish. To this end, adult zebrafish were exposed to three waterborne CdCl2 concentrations (0(control), 5 and 25 μg Cd/l, respectively) for 30 days. Lipid accumulation, the activities of enzymes related to lipid metabolism and oxidative stress, as well as the expression level of genes involved in lipid metabolism and mitophagy were determined in the liver of zebrafish...
March 17, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29568901/puerarin-promotes-min6-cell-survival-by-reducing-cellular-reactive-oxygen-species
#3
Tianxi Wang, Yijie Liu, Caoxin Huang, Hussen Amir Ahmed Mansai, Wenjing Wei, Xiaofang Zhang, Xuejun Li, Suhuan Liu, Shuyu Yang
Type 1 diabetes is caused by destruction of the pancreatic β‑cells and, to date, no cure has been developed. Promoting the survival of pancreatic β‑cells may be beneficial for patients with type 1 diabetes. Puerarin is an estrogen analogue that been demonstrated in previous studies to be able to decreased blood glucose in patients with type 1 diabetes. Similar results were demonstrated in previous studies which additionally demonstrated that puerarin was able to decreased blood glucose in type 1 diabetic mice by protecting pancreatic β‑cells...
May 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29551267/b-cell-specific-diversion-of-glucose-carbon-utilization-reveals-a-unique-vulnerability-in-b-cell-malignancies
#4
Gang Xiao, Lai N Chan, Lars Klemm, Daniel Braas, Zhengshan Chen, Huimin Geng, Qiuyi Chen Zhang, Ali Aghajanirefah, Kadriye Nehir Cosgun, Teresa Sadras, Jaewoong Lee, Tamara Mirzapoiazova, Ravi Salgia, Thomas Ernst, Andreas Hochhaus, Hassan Jumaa, Xiaoyan Jiang, David M Weinstock, Thomas G Graeber, Markus Müschen
B cell activation during normal immune responses and oncogenic transformation impose increased metabolic demands on B cells and their ability to retain redox homeostasis. While the serine/threonine-protein phosphatase 2A (PP2A) was identified as a tumor suppressor in multiple types of cancer, our genetic studies revealed an essential role of PP2A in B cell tumors. Thereby, PP2A redirects glucose carbon utilization from glycolysis to the pentose phosphate pathway (PPP) to salvage oxidative stress. This unique vulnerability reflects constitutively low PPP activity in B cells and transcriptional repression of G6PD and other key PPP enzymes by the B cell transcription factors PAX5 and IKZF1...
March 6, 2018: Cell
https://www.readbyqxmd.com/read/29540210/a-vegetable-induced-hemolytic-crisis-in-a-g6pd-deficient-person-a-case-report
#5
N D B Ehelepola, A N Abayagunawardana, T N Sudusinghe
BACKGROUND: Hemolysis can occur in people with G6PD deficiency under oxidative stress. Acalypha indica is a tropical plant used as a medicinal plant as well as a vegetable. There are a few reported cases of Acalypha indica ingestion induced hemolysis in G6PD deficient people. All except one of them are from Sri Lanka. The information available at present (2017) about G6PD deficiency prevalence and variants of the G6PD gene among Sri Lankans is very sparse. There are no past reports on hemolytic crisis in a G6PD deficient person presenting mimicking leptospirosis...
March 14, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29460183/nutritional-history-does-not-modulate-hepatic-oxidative-status-of-european-sea-bass-dicentrarchus-labrax-submitted-to-handling-stress
#6
Carolina Castro, Amalia Peréz-Jiménez, Filipe Coutinho, Geneviève Corraze, Stéphane Panserat, Helena Peres, Aires Oliva Teles, Paula Enes
The aim of the present study was to assess the impact of an acute handling stress on hepatic oxidative status of European sea bass (Dicentrarchus labrax) juveniles fed diets differing in lipid so urce and carbohydrate content. For that purpose, four diets were formulated with fish oil (FO) and vegetable oils (VO) as lipid source and with 20 or 0% gelatinized starch as carbohydrate source. Triplicate groups of fish with 74 g were fed each diet during 13 weeks and then subjected to an acute handling stress. Stress exposure decreased hematocrit (Ht) and hemoglobin (Hb) levels...
February 19, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29428800/hepatic-transcriptional-profiling-response-to-fava-bean-induced-oxidative-stress-in-glucose-6-phosphate-dehydrogenase-deficient-mice
#7
Guankui Du, Man Xiao, Xiuyu Wei, Chen Zhou, Shuoshuo Li, Wangwei Cai
Favism is an acute hemolytic syndrome caused by the ingestion of fava bean (FB) in glucose 6-phosphate dehydrogenase (G6PD) deficient individuals. However, little is known about the global transcripts alteration in liver tissue after FB ingestion in G6PD-normal and -deficient states. In this study, deep sequencing was used to analyze liver genes expression alterations underlying the effects of FB in C3H (Wild Type, WT) and G6PD-deficient (G6PDx) mice and to evaluate and visualize the collective annotation of a list of genes to Gene Ontology (GO) terms associated with favism...
February 8, 2018: Gene
https://www.readbyqxmd.com/read/29375871/fulminant-hemolysis-in-glucose-6-phosphate-dehydrogenase-deficiency
#8
Bushra Moiz, Sidra Asad Ali
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disorder affecting some 400 million people worldwide. Though clinically silent, it may result in hemolysis on oxidative stress induced by drugs or infections. Viral hepatitis A with coexisting G6PD deficiency can be devastating associated with severe hemolysis, anemia, renal failure, and hepatic encephalopathy.
January 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29336483/glucose-metabolism-during-in-vitro-maturation-of-mouse-oocytes-an-study-using-rna-interference
#9
Hong-Li Xie, Shuai Zhu, Jie Zhang, Jing Wen, Hong-Jie Yuan, Liu-Zhu Pan, Ming-Jiu Luo, Jing-He Tan
In previous studies on glucose metabolism during in vitro maturation, intact cumulus-oocyte complexes (COCs) were treated with enzyme inhibitors/activators. Because inhibitors/activators may have non-specificity and/or toxicity, and culture of COCs cannot differentiate whether glucose metabolism of cumulus cells (CCs) or that of the oocyte supports oocyte maturation, results from the previous studies must be verified by silencing genes in either CCs or cumulus-denuded oocytes (DOs). In this study, RNAi was adopted to specify the effects of glucose metabolism in CCs or DOs on oocyte maturation...
January 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29305344/review-and-drug-therapy-implications-of-glucose-6-phosphate-dehydrogenase-deficiency
#10
REVIEW
Kristen D Belfield, Eric M Tichy
PURPOSE: The pathophysiology, diagnosis, and medication-use implications of glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common enzyme deficiency in humans, are reviewed. SUMMARY: Originally identified as favism in patients who experienced hemolysis after ingestion of fava beans, G6PD deficiency results from an X-linked chromosomal mutation that leads to reduced activity of the enzyme responsible for the final step of the pentose phosphate pathway, through which reduced nicotinamide adenine dinucleotide phosphate required for protection of cells from oxidative stress is produced...
February 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29290982/glucose-6-phosphate-dehydrogenase-and-transketolase-modulate-breast-cancer-cell-metabolic-reprogramming-and-correlate-with-poor-patient-outcome
#11
Adrián Benito, Ibrahim H Polat, Véronique Noé, Carlos J Ciudad, Silvia Marin, Marta Cascante
The pentose phosphate pathway is a fundamental metabolic pathway that provides cells with ribose and NADPH required for anabolic reactions - synthesis of nucleotides and fatty acids - and maintenance of intracellular redox homeostasis. It plays a key role in tumor metabolic reprogramming and has been reported to be deregulated in different types of tumors. Herein, we silenced the most important enzymes of this pathway - glucose-6-phosphate dehydrogenase (G6PD) and transketolase (TKT) - in the human breast cancer cell line MCF7...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29277898/glucose-6-phosphate-dehydrogenase-inhibition-attenuates-acute-lung-injury-through-reduction-in-nadph-oxidase-derived-reactive-oxygen-species
#12
A Nadeem, N O Al-Harbi, S F Ahmad, K E Ibrahim, N Siddiqui, M M Al-Harbi
Acute lung injury (ALI) is a heterogeneous disease with the hallmarks of alveolar capillary membrane injury, increased pulmonary oedema and pulmonary inflammation. The most common direct aetiological factor for ALI is usually parenchymal lung infection or haemorrhage. Reactive oxygen species (ROS) generated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX2) are thought to play an important role in the pathophysiology of ALI. Glucose-6-phosphate dehydrogenase (G6PD) plays an important role both in production of ROS as well as their removal through the supply of NADPH...
March 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29276873/a-case-report-of-a-4-year-old-child-with-glucose-6-phosphate-dehydrogenase-deficiency-an-evidence-based-approach-to-nutritional-management
#13
Alex Pinto, Anita MacDonald, Esmeralda Cleto, Manuela Ferreira Almeida, Paula Cristina Ramos, Júlio César Rocha
Pinto A, MacDonald A, Cleto E, Almeida MF, Ramos PC, Rocha JC. A case report of a 4-year-old child with glucose-6-phosphate dehydrogenase deficiency: An evidence based approach to nutritional management. Turk J Pediatr 2017; 59: 189-192. The objective was to describe the nutritional management of a 4-year-old child with glucose-6-phosphate dehydrogenase (G6PD) deficiency. A 4-year-old male child, African descent, born from non-consanguineous parents presented with a clinical history of frequent respiratory infections, usually treated with antibiotics...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29069580/nicotinamide-prevents-sweet-beverage-induced-hepatic-steatosis-in-rats-by-regulating-the-g6pd-nadph-nadp-and-gsh-gssg-ratios-and-reducing-oxidative-and-inflammatory-stress
#14
Selene Ángeles Mejía, Luis Arturo Baiza Gutman, Clara Ortega Camarillo, Rafael Medina Navarro, Martha Catalina Sánchez Becerra, Leticia Damasio Santana, Miguel Cruz, Elizabeth Hernández Pérez, Margarita Díaz Flores
The disruption of redox state homeostasis, the overexpression of lipogenic transcription factors and enzymes, and the increase in lipogenic precursors induced by sweetened beverages are determinants of the development of nonalcoholic fatty liver disease. This study evaluated the action of nicotinamide (NAM) on the expression of glucose-6-phosphate dehydrogenase (G6PD) and redox, oxidative, and inflammatory states in a model of nonalcoholic hepatic steatosis induced by high and chronic consumption of carbohydrates...
January 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29068590/vitamin-e-%C3%AE-tocopherol-attenuates-toxicity-and-oxidative-stress-induced-by-aflatoxin-in-rats
#15
Seval Yılmaz, Emre Kaya, Selim Comakli
BACKGROUND: Aflatoxins are toxic metabolites produced by Aspergillus flavus and Aspergillus parasiticus and are classified as group I carcinogens by the International Agency for Research on Cancer (IARC). OBJECTIVES: The purpose of this study was to investigate the possible preventive role of vitamin E (Vit E) on aflatoxin (AF) induced toxicity by using biochemical and histopathological approaches. MATERIAL AND METHODS: Wistar-Albino rats were divided into 4 groups as follows: control group, Vit E group (Vit E was administered), AFB1 group (a single dose of AFB1 was administered), AF + Vit E group (AF and Vit E were administered)...
September 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28982343/study-of-glucose-6-phosphate-dehydrogenase-deficiency-5-years-retrospective-egyptian-study
#16
Adel Abd Elhaleim Hagag, Ibrahim M Badraia, Mohamed S Elfarargy, Mohamed M Abd Elmageed, Ehab A Abo-Ali
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency worldwide that causes a spectrum of diseases including neonatal hyperbilirubinemia, acute and chronic hemolysis after exposure to an oxidative stress. AIM OF THE WORK: This five years retrospective study was carried out to study the demographic, clinical and laboratory data of 1000 patients with G6PD deficiency anemia registered in Hematology Unit, Pediatric Department, Tanta University Hospital...
October 3, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28947801/dietary-alterations-modulate-susceptibility-to-plasmodium-infection
#17
Vanessa Zuzarte-Luís, João Mello-Vieira, Inês M Marreiros, Peter Liehl, Ângelo F Chora, Céline K Carret, Tânia Carvalho, Maria M Mota
The relevance of genetic factors in conferring protection to severe malaria has been demonstrated, as in the case of sickle cell trait and G6PD deficiency1 . However, it remains unknown whether environmental components, such as dietary or metabolic variations, can contribute to the outcome of infection2 . Here, we show that administration of a high-fat diet to mice for a period as short as 4 days impairs Plasmodium liver infection by over 90%. Plasmodium sporozoites can successfully invade and initiate replication but die inside hepatocytes, thereby are unable to cause severe disease...
December 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28922657/methods-employed-in-cytofluorometric-assessment-of-eryptosis-the-suicidal-erythrocyte-death
#18
REVIEW
Mohamed Jemaà, Myriam Fezai, Rosi Bissinger, Florian Lang
Suicidal erythrocyte death or eryptosis contributes to or even accounts for anemia in a wide variety of clinical conditions, such as iron deficiency, dehydration, hyperphosphatemia, vitamin D excess, chronic kidney disease (CKD), hemolytic-uremic syndrome, diabetes, hepatic failure, malignancy, arteriitis, sepsis, fever, malaria, sickle-cell disease, beta-thalassemia, Hb-C and G6PD-deficiency, Wilsons disease, as well as advanced age. Moreover, eryptosis is triggered by a myriad of xenobiotics and endogenous substances including cytotoxic drugs and uremic toxins...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28874682/hydrogen-peroxide-dynamics-in-subcellular-compartments-of-malaria-parasites-using-genetically-encoded-redox-probes
#19
Mahsa Rahbari, Stefan Rahlfs, Jude M Przyborski, Anna Katharina Schuh, Nicholas H Hunt, David A Fidock, Georges E Grau, Katja Becker
Redox balance is essential for the survival, growth and multiplication of malaria parasites and oxidative stress is involved in the mechanism of action of many antimalarial drugs. Hydrogen peroxide (H2O2) plays an important role in redox signalling and pathogen-host cell interactions. For monitoring intra- and subcellular redox events, highly sensitive and specific probes are required. Here, we stably expressed the ratiometric H2O2 redox sensor roGFP2-Orp1 in the cytosol and the mitochondria of Plasmodium falciparum (P...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807879/apigenin-induced-abcc1-mediated-efflux-of-glutathione-from-mature-erythrocytes-inhibits-the-proliferation-of-plasmodium-falciparum
#20
Ohud Fallatah, Elias Georges
Plasmodium falciparum infection of mature erythrocytes leads to heightened oxidative stress that is tolerated in normal erythrocytes but not in erythrocytes from sickle cell, β-thalassaemia and glucose-6-phosphate dehydrogenase (G6PD) deficiency hosts. In this report, it was of interest to perturb the redox homeostasis of normal erythrocytes through drug-induced active efflux of glutathione via erythrocyte ABCC1, a member of the C-subfamily of the human ATP-binding cassette (ABC) transporters. To achieve this objective, we made use of apigenin (API), shown previously to activate ABCC1 glutathione efflux in mature erythrocytes...
August 12, 2017: International Journal of Antimicrobial Agents
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