Excentric hypertrophy

OBJECTIVE: The aim of the current case-control study was to use speckle tracking imaging to identify subclinical longitudinal left ventricular systolic function abnormalities in hypertensive subjects with normal ejection fraction (EF). DESIGN AND METHOD: Standard 2D Doppler echocardiography, tissue Doppler imaging, and 2D speckle strain imaging were performed in 50 hypertensive subjects with normal ejection fraction and 50 control subjects.Peak systolic (S) and diastolic (E') annular velocities were obtained by tissue Doppler imaging, whereas longitudinal myocardial strain was obtained by speckle tracking...

OBJECTIVE: The aim is the analysis of hyperuricemia influence on the heart features in patients with arterial hypertension. PATIENTS AND METHODS: Materials and methods: We include 75 patients with arterial hypertension which were divided in two groups according to the level of uric acid in the blood, 30 practically healthy people. Patients from the I group (n = 40) had arterial hypertension and coexistent hyperuricemia; ІІ (n = 35) - arterial hypertension. Left ventricular mass index was determined for left ventricular hypertrophy confirmation...

INTRODUCTION:  Asymmetric dimethylarginin (ADMA) is an endogenous inhibitor of endothelial nitric oxide synthase, considered an effector of endothelial dysfunction. Among multiple diseases associated with elevated ADMA, chronic renal disease is often mentioned. ADMA is thought to be related to certain adverse cardiovascular effects of chronic uremia. The association between left ventricular (LV) structure and function and ADMA has been studied in numerous papers, but only few of them addressed this issue in end‑stage renal disease (ESRD)...

Workers in electrolysis workshops of aluminium plants demonstrate changes in intracardial hemodynamics and left ventricle diastolic function, heart remodelling to concentric and excentric hypertrophy, more in individuals with chronic occupational fluorine intoxication.

AIM: To analyse 24-h rhythm of blood pressure (BP) and its influence on the rate and severity of left ventricular hypertrophy (LVH) in patients with chronic renal failure (CRF) on replacement therapy (peritoneal dialysis - PD). MATERIAL AND METHODS; 70 CRF patients on PD were studied. Their examination included clinical, biochemical tests, automatic 24-hour blood pressure monitoring, transthoracic echocardiography. RESULTS: Non-dipper and night-peaker disorders of BP 24-hour pattern were registered in 81...

AIM: To study left ventricular remodeling (LVR) in patients with end-stage renal disease (ESRD) treated by hemodialysis (HD). MATERIAL AND METHODS: A total of 122 patients with ESRD were examined: 21 patients with predialysis ESRD (group 1), 37 patients treated by HD for 4 hours thrice a week (group 2), 64 patients treated by HD for 5 hours thrice a week (group 3). All the patients have undergone echocardiography. Blood serum hemoglobin, urea, creatinine, albumin, calcium, phosphates, PTH were measured...

Left ventricular hypertrophy represents the structural mechanism of adaptation of the left ventricle as the answer of a chronic pressure overload in arterial hypertension. Initially an increment in left ventricular wall thickness occurs. In this stadium of "concentric hypertrophy" LV systolic wall stress, LV ejection fraction and myocardial oxygen consumption per weight unit myocardium remain unchanged. In the further time course of disease LV dilatation will be present. In this phase of "excentric hypertrophy" LV systolic wall stress and myocardial oxygen consumption per weight unit myocardium rise and LV ejection fraction decreases...

AIM: To study correlation between development of left ventricular hypertrophy (LVH) and remodeling of major arteries at a predialysis stage of chronic renal failure (CRF). MATERIAL AND METHODS: A total of 95 non-diabetic patients (48 males-51% and 47 females-49%) with stage I-III CRF entered the trial. A mean age of the patients was 46.7 years (95% CI 43.7-49.8 years). Glomerular filtration rate calculated by Cockrott-Gault formula was 37.7 ml/min (33.9-41.4 ml/min), blood creatinine level--2...

AIM: To study structural and functional changes in left ventricular myocardium (LVM) of patients with mild and moderate arterial hypertension (AH) with application of tissue myocardial dopplerechocardiography (TMD), correlation between these changes and parameters of electrophysiological remodeling and circadian profile of blood pressure. MATERIAL AND METHODS: Forty-give hypertensive patients were divided into two groups: the study group 2A consisted of 28 patients with mild AH (144...

AIM: To specify cardiomyopathy development in two types of myodystrophy--with complete and partial absence of dystrophin--for detection of the role of genetic and environmental impacts. MATERIAL AND METHODS: Clinical, genetic and electrophysiological examinations, test for creatinphosphokinase (CPK) were made in 113 patients with recessive X-linked Duchenne myodystrophy (DMD) aged 7 to 20 years and with Bekker's myodystrophy (BMD) aged 18 to 60 years. The control group consisted of 112 males matched by age and antropometric parameters...

AIM: To study efficacy and safety of long-term administration of epoetin and iron preparations in glomerulonephritis (GN) patients with chronic kidney disease (CKD) of stage III-IV in systemic diseases. MATERIAL AND METHODS: A total of 189 patients at predialysis stage of CKD (glomerular filtration rate between 15 and 60 ml/min) were randomized into 3 groups depending on GN etiology: primary GN (group 1, 123 patients), GN in systemic diseases (group 2, 45 patients), controls (group 3, 21 patients)...

152 patients with ischemic heart disease aged from 46 to 60 years have been observed. Among these patients, 69 were with stable stenocardia, 32--with unstable stenocardia and 53--in stage related to acute heart attack. Normal geometry of the heart was found in 33% of patients with stable stenocardia, excentric hypertrophy was found in 30% of patients with stable stenocardia. Excentric hypertrophy prevailed in patients with unstable stenocardia and myocardial infarction. Systolic disfunction of the myocardium was found in 72% of patients with stable stenocardia, in 41% of patients with unstable stenocardia and in 43% of patients with myocardial infarction...

AIM: To study specific features of left ventricular remodeling (LVR) in patients with hypertension and diabetes mellitus type 2 (DM-2). MATERIAL AND METHODS: The study group comprised 290 patients, the control group consisted of 79 patients with essential hypertension free of carbohydrate tolerance impairment. The age of the examinees ranged from 35 to 60 years. Structural-geometric left ventricular model was determined by echocardiography. Estimation of significant determinants of myocardial mass index (MMI) and types of left ventricular remodeling was made with multiple regression analysis and logistic regression...

OBJECTIVE: To evaluate the relative contribution of left ventricular (LV) geometric remodeling and of morphological and functional myocardial changes in rats with induced supravalvar aortic stenosis (SAS), in the transition from compensated hypertrophy to congestive heart failure (CHF). METHODS: Twenty one weeks after induction of SAS, the rats were classified as controls (CG, n=13), without congestive heart failure (SG, n=11), or with congestive heart failure (SG-HF, n=12)...

Vascular remodelling describes any change in arterial structure or function during physiological (ageing) and pathological processes such as atherosclerosis and hypertension. Adaptive changes in the short-term may carry pathological consequences in the long-term. The effects of ageing are additive with those of hypertension. The consequences are different according to whether the small resistance arteries or the large arteries of conduction are taken into consideration. The resistance arteries undergo three types of changes: (1) concentric or entrophic remodelling; this is a reorganisation of the same amount of tissue around a smaller diameter; (2) a rarefaction of the arteriolar bed; this is a smaller density of arterioles per unit weight of tissue perfused; (3) early disease of endothelial function with a reduced bio-availability of NO...

AIM: To study dynamics of transmitral circulation (TMC) during a hemodialysis (HD) session in patients with chronic renal failure (CRF) regarding structural-functional alterations of the heart and baseline condition of the diastolic function of left ventricular (LV) myocardium. MATERIAL AND METHODS: Sixty one patients (34 females and 27 males, mean age 47 +/- 11 years) on programmed HD free of heart valvular disease, ischemic heart disease, acute myocardial infarction, atrial fibrillation...

UNLABELLED: Elevated serum concentration of cardiac troponin I (cTnl) is a highly sensitive and specific marker of myocardial damage. Patients with chronic renal failure (crf) treated by hemodialysis often have increased serum cTnl level without evidence of acute myocardial ischemia. In chronic HD patients, elevated serum concentration of endothelin-1 (ET-1) and angiotensin II have been reported which may be associated with ischemic heart disease. The aim of the present study was to investigate possible association between cTnl serum level, ET-I, angiotensin II, other cardiac markers and the structural changes of myocardium assessed by echocardiographic (ECHO) method...

AIM: To study myocardial remodeling (MR) in hypertensive patients with normal and excessive body mass, to analyse MR features depending on clinical and hemodynamic parameters. MATERIAL AND METHODS: Structural-functional conditions of the myocardium were studied with echocardiography, and determination of left ventricular remodeling (LVR) type was made in 734 untreated hypertensive patients aged 19-76 years. RESULTS: Patients with essential hypertension (EH) stage I had mostly excentric left ventricular hypertrophy (LVH)...

We present the case of an 8-year-old female patient with bone dysplasia as part of Dyggve-Melchior-Clausen syndrome (DMCS). MRI was used to evaluate the case. In the spine, odontoid apophysis aplasia was found with no ossification nucleus, vertebrae with central hump, disk protrusions, hypertrophy of the posterior common vertebral ligament, and hidden spina bifida at the S4 level. Morphological anomalies were found in the hips both in the proximal femoral epiphysis, which was located excentrically and laterally to the femoral neck, and in the Y-cartilage, which was greatly enlarged...

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