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https://www.readbyqxmd.com/read/29245172/comment-on-how-fetal-growth-restriction-and-preterm-birth-affects-cardiac-morphology-and-function-during-infancy
#1
P P Bassareo, G Mercuro
We read with great interest the recent paper by Cohen et al regarding the early morphological and functional changes induced by intrauterine growth restriction on the heart and detected during echocardiography(1). In particular, the authors found increases in left ventricular sphericity and posterior and relative wall thicknesses. They also noted that the diastolic function, measured with tissue Doppler imaging, dropped. This article is protected by copyright. All rights reserved.
December 15, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29244030/static-response-of-deformable-microchannels-a-comparative-modelling-study
#2
Tanmay C Shidhore, Ivan C Christov
We present a comparative modelling study of fluid--structure interactions in microchannels. Through a mathematical analysis based on plate theory and the lubrication approximation for low-Reynolds-number flow, we derive models for the flow rate--pressure drop relation for long shallow microchannels with both thin and thick deformable top walls. These relations are tested against full three-dimensional two-way-coupled fluid--structure interaction simulations. Three types of microchannels, representing different elasticity regimes and having been experimentally characterized previously, are chosen as benchmarks for our theory and simulations...
December 15, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29243013/exercise-performance-in-pediatric-liver-transplant-recipients-and-its-related-cardiac-function
#3
Seyed Mohsen Dehghani, Mitra Moshref, Hamid Amoozgar, Seyed Ali Malek Hoseini, Saman Nikeghbalian
The aim of this study was to evaluate an exercise test in pediatric liver transplant recipients and its relation to their cardiac function. This cross-sectional study was conducted on 58 children who had successfully undergone orthotopic liver transplantation at least 6 months prior to the study, with the same age and gender-matched control group. M-mode, Doppler, tissue Doppler echocardiography and an exercise test were performed for all the participants. The VO2 values and METS in patients were less than the control (P = 0...
December 14, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29241163/diagnosis-and-management-of-necrotizing-enterocolitis-an-international-survey-of-neonatologists-and-pediatric-surgeons
#4
Mélanie Valpacos, Delphine Arni, Amy Keir, Ann Aspirot, James C H Wilde, Spencer Beasley, Daniele De Luca, Riccardo E Pfister, Oliver Karam
BACKGROUND: Necrotizing enterocolitis (NEC) is a serious complication of prematurity. Currently, there is limited evidence to guide investigation and treatment strategies. OBJECTIVES: To evaluate the parameters used to diagnose or exclude NEC, and to identify differences between neonatologists and pediatric surgeons. METHODS: A scenario-based survey was sent to neonatologists and pediatric surgeons. RESULTS: 173 physicians from 26 countries completed the survey (55% neonatologists and 45% pediatric surgeons)...
December 15, 2017: Neonatology
https://www.readbyqxmd.com/read/29237827/biomimetic-wall-shaped-adhesive-microstructure-for-shear-induced-attachment-the-effects-of-pulling-angle-and-preliminary-displacement
#5
Jae-Kang Kim, Michael Varenberg
To date, a handful of different gecko-like adhesives inspired by spatula-shaped attachment hairs have been suggested based on wedge and flap geometry of contact elements. However, while these surface designs have been shown to have directionality in adhesion, high friction, long lifetime and the ability to work in vacuum, an experimental verification of the very basic concept of the pulling angle effect has not yet been reported. To close this gap, here we use wall-shaped adhesive microstructures of three different flap heights to systematically study the effect of pulling angle on the normal and tangential components of the pull-off force tested at different preliminary tangential displacements...
December 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29236795/comparative-study-of-intraperitoneal-adhesions-related-to-light-weight-polypropylene-mesh-and-type-i-polymerized-and-purified-bovine-collagen-coated-light-weight-polypropylene-mesh-in-rabbits
#6
Diego Paim Carvalho Garcia, Clarissa Santos, Cristiana Buzelin Nunes, Marcelo Araújo Buzelin, Andy Petroianu, Luiza Ohasi de Figueiredo, Andreia Souto da Motta, Cristiane de Barros Gaspar, Luiz Ronaldo Alberti
PURPOSE: To compare the effectiveness of light-weight polypropylene mesh coated with polymerized and purified bovine type I collagen (Surgidry HNB) in the treatment of abdominal wall defect and the degree of adhesion formation. METHODS: Two types of polypropylene mesh were implanted after creation of defect measuring 6.0cm X 5.5cm in the anterior abdominal wall of 32 male New Zealand breed rabbits, divided in two groups (n = 32): (1) light-weigh macroporous polypropylene, (2) type I polymerized and purified bovine collagen coated light-weigh macroporous polypropylene...
November 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29236270/endoscopic-endonasal-management-of-recurrent-maxillary-mucoceles-using-biliary-t-tube-stenting
#7
Noritsugu Ono, Shin Ito, Hirotomo Homma, Hiroko Okada, Junko Murata, Katsuhisa Ikeda
Mucoceles of the paranasal sinus can be managed endoscopically with an extremely low recurrence rate. Frontal sinus mucoceles can sometimes be prevented from closing and reforming by stenting, which to the best of our knowledge has not yet been reported in the maxillary sinus. We describe the cases of 5 patients-3 men and 2 women, aged 47 to 75 years (mean: 59.6)-with a recurrent and intractable maxillary sinus mucocele that was managed with biliary T-tube stenting. The indications for stenting included recurrent episodes of mucocele with or without a lateral location with a relatively thick bony wall...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29229351/evaluation-of-the-measuring-methods-of-the-spinal-canal-occupation-rate-in-thoracic-ossification-of-ligamentum-flavum
#8
Sheng-Yuan Zhou, Bo Yuan, Chuang Qian, Xiong-Sheng Chen, Lian-Shun Jia
OBJECTIVE: The degree of hypertrophy of thoracic ossification of ligamentum flavum (TOLF) is related to the severity of the myelopathy. There is no uniform measuring method to calculate the spinal canal occupation ratio (COR) of TOLF simply and effectively. The study was to determine an appropriate measuring method to calculate the COR of TOLF. METHODS: A total of 37 computerized tomography (CT) cross-sectional imaging scans (bone window) from 22 patients were analyzed retrospectively in this study...
December 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29226886/two-cases-of-laparoscopic-direct-spiral-closure-of-large-defects-in-the-second-portion-of-the-duodenum-after-laparoscopic-endoscopic-co-operative-surgery
#9
Saseem Poudel, Yuma Ebihara, Kimitaka Tanaka, Yo Kurashima, Soichi Murakami, Toshiaki Shichinohe, Satoshi Hirano
Curative endoscopic resection of non-ampullary duodenal lesions, although possible, is challenging. In recent years, although a novel surgical technique named laparoscopic-endoscopic cooperative surgery (LECS), which combines laparoscopic and endoscopic techniques, has made the resection of nonampullary duodenal lesions relatively easier, closure of the defect is still controversial. We report two cases of the duodenal lesion which were closed using a novel technique for primary closure utilising the free wall of the duodenum...
December 11, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29219948/asperosaponin-vi-promotes-angiogenesis-and-accelerates-wound-healing-in-rats-via-up-regulating-hif-1%C3%AE-vegf-signaling
#10
Cheng-Gui Wang, Yi-Ting Lou, Min-Ji Tong, Li-Lian Zhang, Zeng-Jie Zhang, Yong-Zeng Feng, Shi Li, Hua-Zi Xu, Cong Mao
Wound therapy remains a clinical challenge due to the complexity of healing pathology and high demand of achieving functional and aesthetically satisfactory scars. Newly formed blood vessels are essential for tissue repair since they can support cells at the wound site with nutrition and oxygen. In this study, we investigated the effects of Asperosaponin VI (ASA VI) isolated from a traditional Chinese medicine, the root of Dipsacus asper Wall, in promoting angiogenesis, as well as its function in wound therapeutics...
December 7, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29218105/systemic-inflammation-is-associated-with-myocardial-fibrosis-diastolic-dysfunction-and-cardiac-hypertrophy-in-patients-with-hypertrophic-cardiomyopathy
#11
Lu Fang, Andris H Ellims, Anna L Beale, Andrew J Taylor, Andrew Murphy, Anthony M Dart
BACKGROUND: Regional or diffuse fibrosis is an early feature of hypertrophic cardiomyopathy (HCM) and is related to poor prognosis. Previous studies have documented low-grade inflammation in HCM. The aim of this study was to examine the relationships between circulating inflammatory markers and myocardial fibrosis, systolic and diastolic dysfunction, and the degree of cardiac hypertrophy in HCM patients. METHODS AND RESULTS: Fifty HCM patients were recruited while 20 healthy subjects served as the control group...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29215260/interfacial-adsorption-of-monoclonal-antibody-coe-3-at-the-solid-water-interface
#12
Fang Pan, Zongyi Li, Thomas Leyshon, Dominic Rouse, Ruiheng Li, Charles Smith, Mario Campana, John Robert Peter Webster, Steven M Bishop, Rojaramani Narwal, Christopher F van der Walle, Jim Warwicker, Jian Ren Lu
Spectroscopic ellipsometry (SE) and neutron reflection (NR) data for the adsorption of a monoclonal antibody (mAb, termed COE-3, pI 8.44) at the bare SiO2/water interface are here compared to simulations based on DLVO theory. COE-3 adsorption was characterized by an initial rapid increase in the surface adsorbed amount (Γ) followed by a plateau. Only the initial rate of increase in Γ was strongly correlated to the bulk concentration (0.002-0.2 mg/ml), with Γ at plateau being about 2.2 mg/m2 (pH 5.5). Simulations captured COE-3 adsorption at equilibrium most accurately: the point at which the outgoing flux of molecules within the adsorbed plane matched the adsorption flux...
December 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29214319/electrocardiographic-findings-in-national-basketball-association-athletes
#13
Marc P Waase, R Kannan Mutharasan, William Whang, Marco R DiTullio, John P DiFiori, Lisa Callahan, Jimmie Mancell, Dermot Phelan, Allan Schwartz, Shunichi Homma, David J Engel
Importance: While it is known that long-term intensive athletic training is associated with cardiac structural changes that can be reflected on surface electrocardiograms (ECGs), there is a paucity of sport-specific ECG data. This study seeks to clarify the applicability of existing athlete ECG interpretation criteria to elite basketball players, an athlete group shown to develop significant athletic cardiac remodeling. Objective: To generate normative ECG data for National Basketball Association (NBA) athletes and to assess the accuracy of athlete ECG interpretation criteria in this population...
December 6, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29209684/videolaparoscopic-cholecystectomy-in-patients-with-previous-abdominal-surgery-personal-experience-and-literature-review
#14
G Geraci, B D'Orazio, S Rizzuto, M Cajozzo, G Modica
OBJECTIVES: Laparoscopic cholecystectomy (LC) is today the "gold standard" treatment of gallbladder stones. Role of LC is still debated in the presence of abdominal scars due to the frequent post-operative adhesions which make access to the peritoneal cavity difficult. This study aim to assess role and outcomes of LC on a previous abdominal surgery on the scarred abdomen. MATERIALS AND METHODS: We have carried out a retrospective study on 499 consecutive patients who had undergone LC from 2009 to 2015; 21 of these (4...
November 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29205378/cardiac-gated-parametric-images-from-82-rb-pet-from-dynamic-frames-and-direct-4d-reconstruction
#15
Mary Germino, Richard E Carson
PURPOSE: Cardiac perfusion PET data can be reconstructed as a dynamic sequence and kinetic modeling performed to quantify myocardial blood flow, or reconstructed as static gated images to quantify function. Parametric images from dynamic PET are conventionally not gated, to allow use of all events with lower noise. An alternative method for dynamic PET is to incorporate the kinetic model into the reconstruction algorithm itself, bypassing the generation of a time series of emission images and directly producing parametric images...
December 5, 2017: Medical Physics
https://www.readbyqxmd.com/read/29204231/real-time-elastography-for-the-detection-of-fibrotic-and-inflammatory-tissue-in-patients-with-stricturing-crohn-s-disease
#16
Carla Serra, Fernando Rizzello, Chiara Pratico', Cristina Felicani, Erica Fiorini, Ramona Brugnera, Elena Mazzotta, Francesca Giunchi, Michelangelo Fiorentino, Antonietta D'Errico, Antonio Maria Morselli-Labate, Marianna Mastroroberto, Massimo Campieri, Gilberto Poggioli, Paolo Gionchetti
Purpose: The distinction between active inflammation and fibrosis of the bowel wall is essential for therapeutic decisions in stricturing Crohn's disease. We aimed to assess whether real-time elastography (RTE) with strain ratio measurement could be useful in differentiating fibrotic from inflamed bowel strictures and to evaluate the possible relationship between US techniques and the histology of the stenotic bowel wall. Materials and methods: Bowel ultrasonography (including RTE, color-Doppler and CEUS examination) was prospectively evaluated in 26 patients with symptomatic stricturing Crohn's disease, before surgery...
December 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/29203080/diastolic-wall-strain-is-associated-with-incident-heart-failure-in-african-americans-insights-from-the-atherosclerosis-risk-in-communities-study
#17
Daisuke Kamimura, Takeki Suzuki, Michael E Hall, Wanmei Wang, Michael D Winniford, Amil M Shah, Carlos J Rodriguez, Kenneth R Butler, Thomas H Mosley
BACKGROUND: Increased left ventricular (LV) myocardial stiffness may be associated with impaired LV hemodynamics and incident heart failure (HF). However, an indicator that estimates LV myocardial stiffness easily and non-invasively is lacking. The purpose of this study was to determine whether diastolic wall strain (DWS), an echocardiographic estimator of LV myocardial stiffness, is associated with incident HF in a middle-aged community-based cohort of African Americans. METHODS AND RESULTS: We investigated associations between DWS and incident HF among 1528 African Americans (mean age 58...
December 1, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29195108/novel-combined-index-of-cardiometabolic-risk-related-to-periarterial-fat-improves-the-clinical-prediction-for-coronary-artery-disease-complexity
#18
Maciej Haberka, Michał Lelek, Tomasz Bochenek, Adam Kowalówka, Rafał Młynarski, Katarzyna Mizia-Stec, Zbigniew Gąsior
BACKGROUND AND AIMS: Cardiovascular (CV) risk assessment based on conventional risk factors has a limited performance in the prediction of obstructive coronary artery disease (CAD). Therefore, our aim was to provide a complete assessment on the associations between single or combined cardiovascular ultrasound indexes and the complexity of CAD in high and very-high risk patients. METHODS: Two hundred fifteen patients scheduled for elective coronary angiography were enrolled in the study (F/M: 80/135 pts; age: 61...
September 15, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29193576/adaptive-servo-ventilation-for-central-sleep-apnoea-in-systolic-heart-failure-results-of-the-major-substudy-of-serve-hf
#19
Martin R Cowie, Holger Woehrle, Karl Wegscheider, Eik Vettorazzi, Susanne Lezius, Wolfgang Koenig, Frank Weidemann, Gillian Smith, Christiane Angermann, Marie-Pia d'Ortho, Erland Erdmann, Patrick Levy, Anita K Simonds, Virend K Somers, Faiez Zannad, Helmut Teschler
AIMS: The SERVE-HF trial investigated the impact of treating central sleep apnoea (CSA) with adaptive servo-ventilation (ASV) in patients with systolic heart failure. A preplanned substudy was conducted to provide insight into mechanistic changes underlying the observed effects of ASV, including assessment of changes in left ventricular function, ventricular remodelling, and cardiac, renal and inflammatory biomarkers. METHODS AND RESULTS: In a subset of the 1325 randomised patients, echocardiography, cardiac magnetic resonance imaging (cMRI) and biomarker analysis were performed at baseline, and 3 and 12 months...
November 30, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29191361/comparing-the-effects-of-fluticasone-anti-ige-and-anti-tnf-treatments-in-a-chronic-asthma-model
#20
M Y Ozkars, O Keskin, M Tokur, M Ulasli, B Gogebakan, H Ciralik, E Kucukosmanoglu, C Demirel, S Oztuzcu, H Kahraman
BACKGROUND: Corticosteroids are used in the treatment of asthma. The aim of this study was to determine the efficacy of anti-IgE and anti-TNF alpha as asthma treatments. METHODS: A mouse model of chronic asthma was developed. The fluticasone group was exposed to fluticasone and the anti-IgE and anti-TNF groups were administered anti-IgE or anti-TNF. IL-4, and IgE levels were measured, and histological analysis, pathological analysis and miRNA-126, miRNA-133a analyses were applied...
November 27, 2017: Allergologia et Immunopathologia
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