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https://www.readbyqxmd.com/read/27921168/the-2016-diagnostic-criteria-for-primary-sclerosing-cholangitis
#1
Takahiro Nakazawa, Kenji Notohara, Susumu Tazuma, Atsushi Tanaka, Hiroyuki Isayama, Toshio Tsuyuguchi, Toshiyuki Mori, Hajime Takikawa
BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown cause that is characterized pathologically by an inflammatory and fibrotic process centered on the epithelium, leading to diffuse biliary stenosis and increased wall thickness throughout the intra- and extra-hepatic biliary trees. A nationwide survey in Japan revealed several differences in the clinical aspects of PSC between Japan and Western countries. PSC was recently designated an intractable hepatobiliary disease in Japan...
December 5, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27912983/hypertrophic-obstructive-cardiomyopathy
#2
REVIEW
Josef Veselka, Nandan S Anavekar, Philippe Charron
Hypertrophic obstructive cardiomyopathy is an inherited myocardial disease defined by cardiac hypertrophy (wall thickness ≥15 mm) that is not explained by abnormal loading conditions, and left ventricular obstruction greater than or equal to 30 mm Hg. Typical symptoms include dyspnoea, chest pain, palpitations, and syncope. The diagnosis is usually suspected on clinical examination and confirmed by imaging. Some patients are at increased risk of sudden cardiac death, heart failure, and atrial fibrillation...
November 29, 2016: Lancet
https://www.readbyqxmd.com/read/27905124/assessment-of-early-atherosclerosis-and-left-ventricular-dysfunction-in-children-with-21-hydroxylase-deficiency
#3
Rahmi Özdemir, Hüseyin Anil Korkmaz, Mehmet Küçük, Cem Karadeniz, Timur Meşe, Behzat Özkan
AIM: We analysed 25 children with 21-hydroxylase deficiency who received glucocorticoid and/or mineralocorticoid treatment for at least 12 months to determine the effects of the disease and its treatment on vascular structures and ventricular function. METHODS: Twenty-five patients with 21-hydroxylase-deficient congenital adrenal hyperplasia (CAH) and 25 control subjects were enrolled into this observational, cross-sectional study. The patients were investigated in terms of fasting blood glucose and insulin; fasting serum lipid profile; serum 17-hydroxyprogesterone; dehydroepiandrosterone sulphate; androstenedione; and adrenocorticotropic hormone...
November 7, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27903785/microstructure-and-mechanics-of-healthy-and-aneurysmatic-abdominal-aortas-experimental-analysis-and-modelling
#4
Justyna A Niestrawska, Christian Viertler, Peter Regitnig, Tina U Cohnert, Gerhard Sommer, Gerhard A Holzapfel
Soft biological tissues such as aortic walls can be viewed as fibrous composites assembled by a ground matrix and embedded families of collagen fibres. Changes in the structural components of aortic walls such as the ground matrix and the embedded families of collagen fibres have been shown to play a significant role in the pathogenesis of aortic degeneration. Hence, there is a need to develop a deeper understanding of the microstructure and the related mechanics of aortic walls. In this study, tissue samples from 17 human abdominal aortas (AA) and from 11 abdominal aortic aneurysms (AAA) are systematically analysed and compared with respect to their structural and mechanical differences...
November 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27903534/high-structural-stress-and-presence-of-intraluminal-thrombus-predict-abdominal-aortic-aneurysm-18f-fdg-uptake-insights-from-biomechanics
#5
Yuan Huang, Zhongzhao Teng, Maysoon Elkhawad, Jason M Tarkin, Nikhil Joshi, Jonathan R Boyle, John R Buscombe, Timothy D Fryer, Yongxue Zhang, Ah Yeon Park, Ian B Wilkinson, David E Newby, Jonathan H Gillard, James H F Rudd
BACKGROUND: Abdominal aortic aneurysm (AAA) wall inflammation and mechanical structural stress may influence AAA expansion and lead to rupture. We hypothesized a positive correlation between structural stress and fluorine-18-labeled 2-deoxy-2-fluoro-d-glucose ((18)F-FDG) positron emission tomography-defined inflammation. We also explored the influence of computed tomography-derived aneurysm morphology and composition, including intraluminal thrombus, on both variables. METHODS AND RESULTS: Twenty-one patients (19 males) with AAAs below surgical threshold (AAA size was 4...
November 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27894062/echocardiographic-comparison-between-left-ventricular-non-compaction-and-hypertrophic-cardiomyopathy
#6
Trine F Haland, Jørg Saberniak, Ida S Leren, Thor Edvardsen, Kristina H Haugaa
BACKGROUND: Modern imaging technology has improved detection of left ventricular non-compaction cardiomyopathy (LVNC). Hypertrophic cardiomyopathy (HCM) shares morphological features with LVNC, but prognosis and treatment strategies differ between LVNC and HCM. METHODS AND RESULTS: We aimed to compare global and regional LV myocardial function in LVNC and HCM. We hypothesized that apical function is reduced in LVNC due to the embryonic reduced compaction of the apex...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27890712/quantitative-ct-measures-of-bronchiectasis-in-smokers
#7
Alejandro A Diaz, Thomas P Young, Diego J Maselli, Carlos H Martinez, Ritu Gill, Pietro Nardelli, Wei Wang, Gregory L Kinney, John E Hokanson, George R Washko, Raul San Jose Estepar
BACKGROUND: Bronchiectasis is frequent in smokers with COPD, however there is only limited data on objective assessments of this process. OBJECTIVE: To objectively assess bronchovascular morphology, calculate the ratio of the diameters of bronchial lumen and adjacent artery (BA ratio), and identify those measurements able to discriminate bronchiectasis. METHODS: We collected quantitative computed tomography (QCT) measures of BA ratios, peak wall attenuation, wall thickness (WT), wall area, and wall area percent (WA%) at matched 4(th)-6(th) airway generations in 21 ever smokers with bronchiectasis (cases) and 21 never-smoking controls (control airways)...
November 24, 2016: Chest
https://www.readbyqxmd.com/read/27889505/candesartan-ameliorates-arsenic-induced-hypertensive-vascular-remodeling-by-regularizing-angiotensin-ii-and-tgf-beta-signaling-in-rats
#8
Maibam Wanta Khuman, Sankaran Kutty Harikumar, Abdul Sadam, Manickam Kesavan, Vattaparambil Sukumaran Susanth, Subhashree Parida, Karam Pal Singh, Souvendra Nath Sarkar
Arsenic exposure can cause several cardiovascular diseases, including hypertension, atherosclerosis and microvascular disease. Earlier, we reported that arsenic-mediated enhancement of angiotensin II (AngII) signaling can impair vascular physiology. Here, we investigated whether the AT1 receptor (AT1R) blocker candesartan can ameliorate the arsenic-induced hypertensive vascular remodeling in rats and whether the amelioration could relate to attenuation in vascular AngII and TGF-β signaling. Rats were exposed to sodium arsenite (50ppm) through drinking water for 90 consecutive days...
November 23, 2016: Toxicology
https://www.readbyqxmd.com/read/27885854/gossypibomas-a-surgeon-s-nightmare-patient-demographics-risk-factors-imaging-and-how-we-can-prevent-it
#9
Rishi Philip Mathew, Binston Thomas, Ram Shenoy Basti, Hadihally B Suresh
OBJECTIVES: Gossypibomas are cottinoid matrix left behind following surgery. Due to the legal issues associated with it, very few literature studies are available online, most of them being case reports. The purpose of our study was to identify the patient demographics, risk factors and imaging features. METHODS: Six surgically identified and histopathologically confirmed cases of gossypibomas recorded over a period 7 years from a single tertiary institution were retrospectively evaluated for patient demographics (sex, age, BMI), type of surgery, and duration from time of surgery to onset of symptoms...
November 25, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27884247/machine-learning-algorithms-to-automate-morphological-and-functional-assessments-in-2d-echocardiography
#10
Sukrit Narula, Khader Shameer, Alaa Mabrouk Salem Omar, Joel T Dudley, Partho P Sengupta
BACKGROUND: Machine-learning models may aid cardiac phenotypic recognition by using features of cardiac tissue deformation. OBJECTIVES: This study investigated the diagnostic value of a machine-learning framework that incorporates speckle-tracking echocardiographic data for automated discrimination of hypertrophic cardiomyopathy (HCM) from physiological hypertrophy seen in athletes (ATH). METHODS: Expert-annotated speckle-tracking echocardiographic datasets obtained from 77 ATH and 62 HCM patients were used for developing an automated system...
November 29, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27882404/reduced-trans-mitral-a-wave-velocity-predicts-the-presence-of-wild-type-transthyretin-amyloidosis-in-elderly-patients-with-left-ventricular-hypertrophy
#11
Satoru Yamamura, Yasuhiro Izumiya, Toshifumi Ishida, Yoshiro Onoue, Yuichi Kimura, Shinsuke Hanatani, Satoshi Araki, Koichiro Fujisue, Daisuke Sueta, Hisanori Kanazawa, Seiji Takashio, Hiroki Usuku, Koichi Sugamura, Kenji Sakamoto, Eiichiro Yamamoto, Megumi Yamamuro, Hisayo Yasuda, Sunao Kojima, Koichi Kaikita, Seiji Hokimoto, Hisao Ogawa, Kenichi Tsujita
Wild-type transthyretin amyloidosis (ATTRwt) is often overlooked in elderly patients with left ventricular hypertrophy (LVH). Impaired atrial function, in addition to ventricular diastolic dysfunction, is one of the hallmarks of cardiac amyloidosis. Here, we assessed the hypothesis that atrial function evaluated by A-velocity in pulse Doppler echocardiography is useful to differentiate ATTRwt in elderly patients with LVH. We analyzed 133 consecutive patients who underwent tissue biopsy to rule out infiltrative cardiomyopathy in our institute...
November 23, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27876369/multi-component-model-of-intramural-hematoma
#12
Martina Bukač, Mark Alber
A novel multi-component model is introduced for studying interaction between blood flow and deforming aortic wall with intramural hematoma (IMH). The aortic wall is simulated by a composite structure submodel representing material properties of the three main wall layers. The IMH is described by a poroelasticity submodel which takes into account both the pressure inside hematoma and its deformation. The submodel of the hematoma is fully coupled with the aortic submodel as well as with the submodel of the pulsatile blood flow...
November 15, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27875727/predictor-of-left-ventricular-dysfunction-after-aortic-valve-replacement-in-mixed-aortic-valve-disease
#13
Alexander C Egbe, Carole A Warnes
BACKGROUND: The fate of the left ventricle (LV) after aortic valve replacement (AVR) in mixed aortic valve disease (MAVD) is unknown. METHODS: Patients with moderate-severe MAVD, ejection fraction ≥50%, and no coronary artery disease who underwent AVR were identified. Moderate-severe MAVD was defined as a combination of ≥moderate aortic stenosis and ≥moderate aortic regurgitation. Assessment for LVD was performed at 1 and 5years after AVR. The purpose of the study was to determine prevalence and predictors of early and late left ventricular dysfunction (LVD) defined as ejection fraction <50% at 1 and 5years post-AVR...
November 14, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27869084/verification-of-dose-distribution-in-carbon-ion-radiation-therapy-for-stage-i-lung-cancer
#14
Daisuke Irie, Jun-Ichi Saitoh, Katsuyuki Shirai, Takanori Abe, Yoshiki Kubota, Makoto Sakai, Shin-Ei Noda, Tatsuya Ohno, Takashi Nakano
PURPOSE: To evaluate robustness of dose distribution of carbon-ion radiation therapy (C-ion RT) in non-small cell lung cancer (NSCLC) and to identify factors affecting the dose distribution by simulated dose distribution. METHODS AND MATERIALS: Eighty irradiation fields for delivery of C-ion RT were analyzed in 20 patients with stage I NSCLC. Computed tomography images were obtained twice before treatment initiation. Simulated dose distribution was reconstructed on computed tomography for confirmation under the same settings as actual treatment with respiratory gating and bony structure matching...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27865737/echocardiographic-assessment-of-feline-false-tendons-and-their-relationship-with-focal-thickening-of-the-left-ventricle
#15
O A Wolf, M Imgrund, G Wess
BACKGROUND: False tendons (FTs) are string-like structures in the left ventricle. A FT might produce focal thickening at its insertion region of the left ventricle, which could be mistaken for focal hypertrophic cardiomyopathy. OBJECTIVES: To perform a prospective, echocardiographic follow-up examination of feline FTs and compare the wall thickness at the FT insertion region and a normal region without FTs at both examinations. ANIMALS: One hundred twenty-eight cats with one or multiple FTs without other cardiac abnormalities or systemic disease...
November 16, 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/27865722/effect-of-sex-and-sporting-discipline-on-lv%C3%A2-adaptation-to-exercise
#16
Gherardo Finocchiaro, Harshil Dhutia, Andrew D'Silva, Aneil Malhotra, Alexandros Steriotis, Lynne Millar, Keerthi Prakash, Rajay Narain, Michael Papadakis, Rajan Sharma, Sanjay Sharma
OBJECTIVES: This study sought to investigate the effect of different types of exercise on left ventricular (LV) geometry in a large group of female and male athletes. BACKGROUND: Studies assessing cardiac adaptation in female and male athletes indicate that female athletes reveal smaller increases in LV wall thickness and cavity size compared with male athletes. However, data on sex-specific changes in LV geometry in athletes are scarce. METHODS: A total of 1,083 healthy, elite, white athletes (41% female; mean age 21...
November 11, 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27864722/comparison-between-submucosal-tunneling-endoscopic-resection-and-endoscopic-full-thickness-resection-for-gastric-stromal-tumors-originating-from-the-muscularis-propria-layer
#17
Yuyong Tan, Xiaoyu Tang, Ting Guo, Dongzi Peng, Yao Tang, Tianying Duan, Xuehong Wang, Liang Lv, Jirong Huo, Deliang Liu
BACKGROUND: Both submucosal tunneling endoscopic resection (STER) and endoscopic full-thickness resection (EFTR) are effective method for treating gastric gastrointestinal stromal tumors (GISTs); however, little is known about the comparison between STER and EFTR. The aim of the study was to compare the safety and efficacy of STER and EFTR for treating gastric GIST. METHODS: We retrospectively collected the clinical data about patients with gastric GISTs who received STER or EFTR at our hospital from April 2011 to June 2016...
November 18, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27862362/morphometric-traits-of-gizzard-in-relation-to-feeding-habits-of-wild-sardinian-partridges-alectoris-barbara-barbara-bonnaterre-1790-with-particular-regard-to-clast-selection
#18
M G Cappai, G Arru, M Manconi, M Muzzeddu, W Pinna
Housing and feeding practices of wild birds for conservation management of biodiversity or restocking play a crucial role in determining the survival rates of animals when released into nature. Failure in coping with the environment might be one of the main flaws captive animals can experience when put into natural habitat. The present investigation aimed at exploring feeding habits and related morphometric traits of gizzard with respective content from wild partridges in comparison with captive ones. A total of 52 hunted wild Sardinian adult partridges (Alectoris barbara barbara Bonnaterre, 1790) were used...
November 13, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/27861214/body-mass-hides-the-curve-thoracic-scoliometer-readings-vary-by-body-mass-index-value
#19
Adam Margalit, Greg McKean, Adam Constantine, Carol B Thompson, Rushyuan Jay Lee, Paul D Sponseller
BACKGROUND: Guidelines suggest referral for scoliosis when rib slope (scoliometer measurement, angle of trunk rotation) is ≥7 degrees. We hypothesized that overweight and obese patients would have lower scoliometer measurements compared with normal-weight and underweight patients for a given spinal curvature, causing overweight and obese patients with adolescent idiopathic scoliosis to present for treatment later and with larger curves. Our goal was to determine the association between scoliometer readings and major curve magnitudes in relation to body mass index (BMI)...
November 17, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27859288/exploring-key-cellular-processes-and-candidate-genes-regulating-the-primary-thickening-growth-of-moso-underground-shoots
#20
Qiang Wei, Chen Jiao, Lin Guo, Yulong Ding, Junjie Cao, Jianyuan Feng, Xiaobo Dong, Linyong Mao, Honghe Sun, Fen Yu, Guangyao Yang, Peijian Shi, Guodong Ren, Zhangjun Fei
The primary thickening growth of Moso (Phyllostachys edulis) underground shoots largely determines the culm circumference. However, its developmental mechanisms remain largely unknown. Using an integrated anatomy, mathematics and genomics approach, we systematically studied cellular and molecular mechanisms underlying the growth of Moso underground shoots. We discovered that the growth displayed a spiral pattern and pith played an important role in promoting the primary thickening process of Moso underground shoots and driving the evolution of culms with different sizes among different bamboo species...
November 12, 2016: New Phytologist
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