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https://www.readbyqxmd.com/read/28822455/-feasibility-analysis-of-predicting-the-risk-of-pancreatic-fistula-after-pancreatoduodenectomy-by-preoperative-ct
#1
M Yu, Y D Wang, H Z Xue, Q Shen, J Xu, X Zhang, J K Jia, M Jia
Objective: To study the preoperative computed tomography (CT) data of patients with pancreaticoduodenectomy (PD) and to explore the effective of predicting the risk of postoperative pancreatic fistula (POPF). Methods: CT images of patients with PD were analyzed retrospectively from June 2010 to January 2017 in Zhengzhou University of People's Hospital. The pancreas index, pancreatic duct width, pancreas CT value, pancreas-spleen CT value, and pancreas thickness were collected. The relationship between the indicators and the POPF was determined, and the receiver operation characteristic (ROC) curve was calculated and the area under the curve (AUC) was evaluated...
August 8, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28812000/diagnostic-imaging-features-of-necrotizing-enterocolitis-a-narrative-review
#2
REVIEW
Francesco Esposito, Rosanna Mamone, Marco Di Serafino, Carmela Mercogliano, Valerio Vitale, Gianfranco Vallone, Patrizia Oresta
Necrotizing enterocolitis (NEC) is an inflammatory process, characterized by intestinal necrosis of variable extension, leading to perforation, generalized peritonitis and death. The classical pathogenetic theory focuses on mucosal damage related to a stress induced intestinal ischemia leading to mucosal injury and bacterial colonization of the wall. A more recent hypothesis emphasizes the role of immaturity of gastrointestinal and immune system, particularly of the premature, responsible of bowel wall vulnerability and suffering...
June 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28811655/a-tissue-engineered-blood-vessel-model-of-hutchinson-gilford-progeria-syndrome-using-human-ipsc-derived-smooth-muscle-cells
#3
Leigh Atchison, Haoyue Zhang, Kan Cao, George A Truskey
Hutchison-Gilford Progeria Syndrome (HGPS) is a rare, accelerated aging disorder caused by nuclear accumulation of progerin, an altered form of the Lamin A gene. The primary cause of death is cardiovascular disease at about 14 years. Loss and dysfunction of smooth muscle cells (SMCs) in the vasculature may cause defects associated with HGPS. Due to limitations of 2D cell culture and mouse models, there is a need to develop improved models to discover novel therapeutics. To address this need, we produced a functional three-dimensional model of HGPS that replicates an arteriole-scale tissue engineered blood vessel (TEBV) using induced pluripotent stem cell (iPSC)-derived SMCs from an HGPS patient...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811219/trinucleotide-repeat-containing-6c-tnrc6c-is-essential-for-microvascular-maturation-during-distal-airspace-sacculation-in-the-developing-lung
#4
Hua Guo, Yana Kazadaeva, Fabian E Ortega, Narasimaswamy Manjunath, Tushar J Desai
GW182 (also known asTNRC6) family members are critically involved in the final effector phase of miRNA-mediated mRNA repression. The three mammalian paralogs, TNRC6a, b and c, are thought to be redundant based on Argonaute (Ago) binding, tethering assays, and RNAi silencing of individual members in cell lines. To test this idea, we generated TNRC6a, b and c knockout mice. TNRC6a mutants die at mid-gestation, while b- and c- deleted mice are born at a Mendelian ratio. However, the majority of TNRC6b and all TNRC6c mutants die within 24h after birth, the latter with respiratory failure...
August 12, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28810543/atorvastatin-has-a-protective-effect-in-a-mouse-model-of-bronchial-asthma-through-regulating-tissue-transglutaminase-and-triggering-receptor-expressed-on-myeloid-cells-1-expression
#5
Ming-Wei Liu, Rong Liu, Hai-Ying Wu, Mei Chen, Min-Na Dong, Yun-Qiao Huang, Chun-Hai Zhang, Yin-Zhong Wang, Jing Xia, Yang Shi, Feng-Mei Xie, Hua Luo, Xin-Yuan Zhao, Wei Wei, Mei-Xian Su
Airway remodeling in asthma contributes to airway hyperreactivity, loss of lung function and persistent symptoms. Current therapies do not adequately treat the structural airway changes associated with asthma. Statin drugs have improved respiratory health and their therapeutic potential in asthma has been tested in clinical trials. However, the mechanism of action of statins in this context has remained elusive. The present study hypothesized that atorvastatin treatment of ovalbumin-exposed mice attenuates early features of airway remodeling via a mevalonate-dependent mechanism...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28803112/in-vivo-documentation-of-shape-and-position-changes-of-mri-visible-mesh-placed-in-rectovaginal-septum
#6
Urbankova Iva, Sindhwani Nikhil, Callewaert Geertje, Turri Alice, Rinkijevic Rita, Hympanova Lucie, Feola Andrew, Deprest Jan
BACKGROUND AND OBJECTIVE: Large deformations in synthetic meshes used in pelvic organ prolapse surgery may lead to suboptimal support for the underlying tissue, graft-related complications as well as recurrence. Our aim was to quantify in vivo longitudinal changes in mesh shape and geometry in a large animal model. We compare two commonly used mesh shapes, armed and flat, that are differently affixed. The secondary outcomes were active and passive biomechanical properties. METHODS: A total of 18 animals were used...
August 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28802195/measurements-and-simulation-of-liquid-films-during-drainage-displacements-and-snap-off-in-constricted-capillary-tubes
#7
Sophie Roman, Moataz O Abu-Al-Saud, Tetsu Tokunaga, Jiamin Wan, Anthony R Kovscek, Hamdi A Tchelepi
When a wetting liquid is displaced by air in a capillary tube, a wetting film develops between the tube wall and the air that is responsible for the snap-off mechanism of the gas phase. By dissolving a dye in the wetting phase it is possible to relate a measure of the absorbance in the capillary to the thickness of liquid films. These data could be used to compare with cutting edge numerical simulations of the dynamics of snap-off for which experimental and numerical data are lacking. Drainage experiments in constricted capillary tubes were performed where a dyed wetting liquid is displaced by air for varying flow rates...
July 26, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28798242/a-rare-urological-presentation-of-appendicitis
#8
Nick Simson, Thomas Stonier, Alberto Coscione, Ahmed Qteishat
A 17-year-old boy with no medical comorbidities, but a significant family history of malignancy, presented to Accident and Emergency following 3 days of increasing rectal pain, symptoms of bladder outflow obstruction (poor flow, intermittent stream and hesitancy) and dysuria. Notably he had no abdominal pain. Digital rectal examination revealed a tender, enlarged prostate. Inflammatory markers were significantly raised (white cell count 17.7, C reactive protein 191). He was diagnosed clinically as prostatitis and commenced on intravenous antibiotics...
August 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28794574/pseudodidymellaceae-fam-nov-phylogenetic-affiliations-of-mycopappus-like-genera-in-dothideomycetes
#9
A Hashimoto, M Matsumura, K Hirayama, R Fujimoto, K Tanaka
The familial placement of four genera, Mycodidymella, Petrakia, Pseudodidymella, and Xenostigmina, was taxonomically revised based on morphological observations and phylogenetic analyses of nuclear rDNA SSU, LSU, tef1, and rpb2 sequences. ITS sequences were also provided as barcode markers. A total of 130 sequences were newly obtained from 28 isolates which are phylogenetically related to Melanommataceae (Pleosporales, Dothideomycetes) and its relatives. Phylogenetic analyses and morphological observation of sexual and asexual morphs led to the conclusion that Melanommataceae should be restricted to its type genus Melanomma, which is characterised by ascomata composed of a well-developed, carbonaceous peridium, and an aposphaeria-like coelomycetous asexual morph...
June 2017: Studies in Mycology
https://www.readbyqxmd.com/read/28794209/phylloquinone-intake-is-associated-with-cardiac-structure-and-function-in-adolescents
#10
Mary K Douthit, Mary Ellen Fain, Joshua T Nguyen, Celestine F Williams, Allison H Jasti, Bernard Gutin, Norman K Pollock
Background: Associations between childhood vitamin K consumption and cardiac structure and function have not been investigated.Objective: We determined associations between phylloquinone (vitamin K-1) intake and left ventricular (LV) structure and function in adolescents.Methods: We assessed diet with three to seven 24-h recalls and physical activity (PA) by accelerometry in 766 adolescents (aged 14-18 y, 50% female, 49% black). Fat-free soft tissue (FFST) mass and fat mass were measured by dual-energy X-ray absorptiometry...
August 9, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28774021/mechanical-properties-of-auxetic-cellular-material-consisting-of-re-entrant-hexagonal-honeycombs
#11
Xiangwen Zhang, Deqing Yang
A preliminary study of the mechanical properties of auxetic cellular material consisting of re-entrant hexagonal honeycombs is presented. For different scales of the honeycombs, the finite element method (FEM) and experimental models are used to perform a parametric analysis on the effects of the Poisson's ratio (cell angle) and the relative density (cell thickness) of honeycombs on bearing capacity and dynamic performance of the auxetic material. The analysis demonstrates that the ultimate bearing capacity of the presented auxetic cellular material is scale-independent when the Poisson's ratio and the relative density are kept constant...
November 7, 2016: Materials
https://www.readbyqxmd.com/read/28773235/synchrotron-microtomography-reveals-the-fine-three-dimensional-porosity-of-composite-polysaccharide-aerogels
#12
Abdul Ghafar, Kirsti Parikka, David Haberthür, Maija Tenkanen, Kirsi S Mikkonen, Jussi-Petteri Suuronen
This study investigates the impact of ice-templating conditions on the morphological features of composite polysaccharide aerogels in relation to their mechanical behavior and aims to get a better insight into the parameters governing these properties. We have prepared polysaccharide aerogels of guar galactomannan (GM) and tamarind seed xyloglucan (XG) by enzymatic oxidation with galactose oxidase (GaO) to form hydrogels, followed by conventional and unidirectional ice-templating (freezing) methods and lyophilization to form aerogels...
July 28, 2017: Materials
https://www.readbyqxmd.com/read/28772634/mechanical-behavior-of-recycled-aggregate-concrete-filled-steel-tubular-columns-before-and-after-fire
#13
Wenchao Liu, Wanlin Cao, Jianwei Zhang, Ruwei Wang, Lele Ren
Recycled aggregate concrete (RAC) is an environmentally friendly building material. This paper investigates the mechanical behavior of recycled aggregate concrete filled steel tube (RACFST) columns exposed to fire. Two groups of 12 columns were designed and tested, under axial compression, before and after fire, to evaluate the degradation of bearing capacity due to fire exposure. Six specimens were subjected to axial compression tests at room temperature and the other six specimens were subjected to axial compression tests after a fire exposure...
March 9, 2017: Materials
https://www.readbyqxmd.com/read/28770454/acute-pulmonary-edema-in-patients-with-reduced-left-ventricular-ejection-fraction-is-associated-with-concentric-left-ventricular-geometry
#14
Junichi Imanishi, Kenji Kaihotsu, Sachiko Yoshikawa, Makoto Nishimori, Naohiko Sone, Tomoyuki Honjo, Masanori Iwahashi
Although acute pulmonary edema (APE) is common in patients with heart failure (HF) with preserved ejection fraction (EF), its pathogenesis in patients with HF with reduced EF (HFrEF) is not completely understood. The purpose of our study was to explore the contributions of left ventricular (LV) geometry to understand the difference between HFrEF patients with or without APE. We studied 122 consecutive acute decompensated HF patients with HFrEF (≤40%). APE was defined as acute-onset dyspnea and radiographic alveolar edema requiring immediate airway intervention...
August 2, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28766470/effects-of-isovalerate-supplements-on-morphology-and-functional-gene-expression-of-rumen-mucosa-in-pre-and-post-weaning-dairy-calves
#15
Q Liu, C Wang, G Guo, W J Huo, Y L Zhang, C X Pei, S L Zhang, H Wang
Isovalerate supplements could stimulate rumen development by improving morphology and function of rumen mucosa, and then promote the growth of calves. This study was done to evaluate the effects of isovalerate supplements on morphology and functional gene expression of rumen mucosa in dairy calves. In total, 48 Chinese Holstein male calves with 15 days of age and 45.1±0.36 kg of BW were randomly assigned to four groups. The treatments were: control, low-isovalerate, moderate-isovalerate and high-isovalerate with 0, 3, 6 and 9 g isovalerate per calf per day, respectively...
August 2, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28766047/prognostic-value-of-cardiovascular-magnetic-resonance-imaging-for-life-threatening-arrhythmia-detected-by-implantable-cardioverter-defibrillator-in-japanese-patients-with-hypertrophic-cardiomyopathy
#16
Yasuki Hen, Mayuko Tsugu-Yagawa, Nobuo Iguchi, Yuko Utanohara, Kaori Takada, Haruhiko Machida, Ayako Takara, Kunihiko Teraoka, Kanki Inoue, Itaru Takamisawa, Morimasa Takayama, Tsutomu Yoshikawa
Implantable cardioverter-defibrillator (ICD) is effective to prevent sudden death in HCM patients. We reviewed ICD records to analyze the relation between life-threatening arrhythmia and late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) in Japanese hypertrophic cardiomyopathy (HCM) patients. In 102 consecutive patients (median age 63 years, 63 males) implanted with an ICD after CMR with gadolinium enhancement (median follow-up 2.8 years), the outcome of life-threatening arrhythmic events (appropriate ICD interventions for ventricular tachycardia or ventricular fibrillation) was examined...
August 1, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28761681/smoking-intensity-and-duration-is-associated-with-cardiac-structure-and-function-the-echocardiographic-study-of-hispanics-latinos
#17
J Adam Leigh, Robert C Kaplan, Katrina Swett, Pelbreton Balfour, Mayank M Kansal, Gregory A Talavera, Krista Perreira, Michael J Blaha, Emelia J Benjamin, Rosemarie Robertson, Aruni Bhartnagar, Carlos J Rodriguez
OBJECTIVE: Cardiovascular disease is the leading cause of death in smokers and this relationship is complicated by the multiplicity of cardiovascular effects of smoking. However, the relationship between intensity and duration of cigarette smoking and echocardiographic measures of right and left ventricular structure and function has been poorly studied. METHODS: We examined ECHO-SOL (Echocardiographic Study of Hispanics/Latinos) participants, a subset of the Hispanic Community Health Study/Study of Latinos...
2017: Open Heart
https://www.readbyqxmd.com/read/28761667/correlation-between-capillary-oxygen-saturation-and-small-intestinal-wall-thickness-in-the-equine-colic-patient
#18
Elisabeth Mirle, Anna Wogatzki, Robert Kunzmann, Axel M Schoenfelder, Lutz F Litzke
The surgical evaluation of haemorrhagic infarcted intestine and the decision for or against bowel resection require a lot of experience and are subjective. The aim of this prospective, clinical study was to examine the correlation between oxygen saturation and small intestinal wall (IW) thickness, using two objective methods. In 22 colicky horses, the blood flow, oxygen saturation and relative amount of haemoglobin were measured intraoperatively via laser Doppler and white light spectroscopy (O2C, oxygen to see, LEA Medizintechnik) at six measuring points (MPs) in small and large intestines...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/28758847/sex-related-differences-in-bronchial-parameters-and-pulmonary-function-test-results-in-patients-with-chronic-obstructive-pulmonary-disease-based-on-three-dimensional-quantitative-computed-tomography
#19
Yan Li, Yong-Liang Dai, Nan Yu, You-Min Guo
Objective This study was performed to evaluate the effect of sex on bronchial parameters and the predicted forced expiratory volume in 1 s expressed as a percentage of the forced vital capacity (FEV1% pred) on pulmonary function testing. Methods The data of 359 patients with chronic obstructive pulmonary disease (COPD) with available FEV1% pred and computed tomography (CT) images were retrospectively reviewed. FACT-Digital lung TM software (DeXin, Xi'an, China) was used to perform fully automated three-dimensional CT quantitative measurements of the bronchi...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28754383/structures-of-apolipoprotein-a-i-in-high-density-lipoprotein-generated-by-electron-microscopy-and-biased-simulations
#20
Lin Zhu, Jitka Petrlova, Peter Gysbers, Hans Hebert, Stefan Wallin, Caroline Jegerschöld, Jens O Lagerstedt
BACKGROUND: Apolipoprotein A-I (apoA-I) in high-density lipoprotein (HDL) is a key protein for the transport of cholesterol from the vascular wall to the liver. The formation and structure of nascent HDL, composed of apoA-I and phospholipids, is critical to this process. METHODS: The HDL was assembled in vitro from apoA-I, cholesterol and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) at a 1:4:50 molar ratio. The structure of HDL was investigated in vitreous samples, frozen at cryogenic temperatures, as well as in negatively stained samples by transmission electron microscopy...
July 25, 2017: Biochimica et Biophysica Acta
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