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https://www.readbyqxmd.com/read/29688417/correlating-clinical-risk-factors-and-histological-features-in-ruptured-and-unruptured-human-intracranial-aneurysms-the-swiss-aneux-study
#1
Sandrine Morel, Mannekomba R Diagbouga, Nicolas Dupuy, Esther Sutter, Vincent Braunersreuther, Graziano Pelli, Marco Corniola, Renato Gondar, Max Jägersberg, Nathalie Isidor, Karl Schaller, Marie-Luce Bochaton-Piallat, Philippe Bijlenga, Brenda R Kwak
Pathogenesis of intracranial aneurysm is complex and the precise biomechanical processes leading to their rupture are uncertain. The goal of our study was to characterize the aneurysmal wall histologically and to correlate histological characteristics with clinical and radiological factors used to estimate the risk of rupture. A new biobank of aneurysm domes resected at the Geneva University Hospitals (Switzerland) was used. Histological analysis revealed that unruptured aneurysms have a higher smooth muscle cell (SMC) content and a lower macrophage content than ruptured domes...
April 23, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29682020/morphometric-analysis-of-dose-dependent-effect-of-progesterone-on-experimental-vasospasm-induced-rat-femoral-arteries
#2
Metin Kasap, Huseyin Canaz, Gokhan Canaz, Mehmet Tokmak, Alper Bingul, Ibrahim Alatas
Objective: Our aim of this study was to determine effective doses of progesterone which has a vasodilatory effect during the early stage of vasospasm. Cerebral vasospasm (CV) is a predominant cause of morbidity and mortality which develops following subarachnoidal hemorrhage (SAH). Etiopathogenesis of CV is multifactorial. Despite many previously performed studies on this issue, the mechanism by which blood and blood products in the subarachnoidal space induce CV has not been clarified yet...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681734/three-new-species-of-fomitiporella-hymenochaetales-basidiomycota-based-on-the-evidence-from-morphology-and-dna-sequence-data
#3
Xiao-Hong Ji, Josef Vlasák, Xue-Mei Tian, Yu-Cheng Dai
Fomitiporella austroasiana , F. mangrovei and F. vietnamensis are described and illustrated as new species based on morphological characters and molecular evidence. They have annual to perennial, mostly resupinate basidiomata with grayish fresh pores, an indistinct subiculum, lack any kind of setae, have brownish, thick-walled basidiospores, and cause a white rot. The distinctive morphological characters of the new species and their related species are discussed. Phylogenies based on the nuclear ribosomal large subunit (28S) and the nuclear ribosomal ITS region show that these three new species form three distinct lineages in the Fomitiporella clade...
2018: MycoKeys
https://www.readbyqxmd.com/read/29681423/ultrasonic-cavitation-enabled-treatment-for-therapy-of-hypertrophic-cardiomyopathy-proof-of-principle
#4
Douglas L Miller, Xiaofang Lu, Chunyan Dou, Yiying I Zhu, Rachael Fuller, Kristina Fields, Mario L Fabiilli, Gabe E Owens, David Gordon, Oliver D Kripfgans
Ultrasound myocardial cavitation-enabled treatment was applied to the SS-16BN rat model of hypertrophic cardiomyopathy for proof of the principle underlying myocardial reduction therapy. A focused ultrasound transducer was targeted using 10-MHz imaging (10 S, GE Vivid 7) to the left ventricular wall of anesthetized rats in a warmed water bath. Pulse bursts of 4-MPa peak rarefactional pressure amplitude were intermittently triggered 1:8 heartbeats during a 10-min infusion of a microbubble suspension. Methylprednisolone was given to reduce initial inflammation, and Losartan was given to reduce fibrosis in the healing tissue...
April 19, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29679099/radiation-induced-carotid-artery-lesions
#5
REVIEW
Verónica Fernández-Alvarez, Fernando López, Carlos Suárez, Primoz Strojan, Avraham Eisbruch, Carl E Silver, William M Mendenhall, Johannes A Langendijk, Alessandra Rinaldo, Anne W M Lee, Jonathan J Beitler, Robert Smee, Javier Alvarez, Alfio Ferlito
PURPOSE: To review the current aspects of knowledge related to the risk of cerebrovascular events in patients receiving head and neck radiotherapy. METHODS: A literature search was performed in PubMed. Papers meeting selection criteria were reviewed. RESULTS: We provide an update on the problem by identifying key studies that have contributed to our current understanding of the epidemiology, radiologic features, pathogenesis, and treatment of the disease...
April 20, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29678777/a-10-year-review-of-sudden-death-during-sporting-activities
#6
Mark Dennis, Alexander Elder, Christopher Semsarian, John Orchard, Isabel Brouwer, Rajesh Puranik
BACKGROUND: Sudden death during sport is a rare but devastating event. Previous research has mostly focused on sudden deaths in young competitive athletes. OBJECTIVE: To characterise the demographics and aetiology of sudden cardiac death (SCD) during sport in Australia. METHODS: All autopsies conducted at our forensic medicine facility between the years 2006-2015 (inclusive) were reviewed. Sporting related deaths amongst those 7-65 years of age were identified...
April 17, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29676468/cell-wall-properties-in-oryza-sativa-influence-mesophyll-co-2-conductance
#7
Patrícia V Ellsworth, Patrick Z Ellsworth, Nuria K Koteyeva, Asaph B Cousins
Diffusion of CO2 from the leaf intercellular air space to the site of carboxylation (gm ) is a potential trait for increasing net rates of CO2 assimilation (Anet ), photosynthetic efficiency, and crop productivity. Leaf anatomy plays a key role in this process; however, there are few investigations into how cell wall properties impact gm and Anet . Online carbon isotope discrimination was used to determine gm and Anet in Oryza sativa wild-type (WT) plants and mutants with disruptions in cell wall mixed-linkage glucan (MLG) production (CslF6 knockouts) under high- and low-light growth conditions...
April 20, 2018: New Phytologist
https://www.readbyqxmd.com/read/29668853/the-links-between-leaf-hydraulic-vulnerability-to-drought-and-key-aspects-of-leaf-venation-and-xylem-anatomy-among-26-australian-woody-angiosperms-from-contrasting-climates
#8
Chris J Blackman, Sean M Gleason, Alicia M Cook, Yvonne Chang, Claire A Laws, Mark Westoby
Background and Aims: The structural properties of leaf venation and xylem anatomy strongly influence leaf hydraulics, including the ability of leaves to maintain hydraulic function during drought. Here we examined the strength of the links between different leaf venation traits and leaf hydraulic vulnerability to drought (expressed as P50leaf by rehydration kinetics) in a diverse group of 26 woody angiosperm species, representing a wide range of leaf vulnerabilities, from four low-nutrient sites with contrasting rainfall across eastern Australia...
April 14, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29668460/relations-of-apelin-with-cardiac-remodeling-in-patients-with-hypertension-and-type-2-diabetes
#9
Sergiy Koval, Kostiantyn Iushko, Tatyana Starchenko
BACKGROUND: The peptide apelin has antihypertensive and antidiabetic properties, but its role in the processes of cardiac remodeling in patients with hypertension and type 2 diabetes (T2D) is poorly understood. AIM: The aim of the study was to investigate apelin levels in patients with hyper-tension and T2D and to determine its relations to heart structural parameters and types of cardiac remodeling. MATERIALS AND METHODS: We examined 63 patients with hypertension and T2D...
March 1, 2018: Folia Medica
https://www.readbyqxmd.com/read/29663506/new-classification-of-geometric-ventricular-patterns-in-severe-aortic-stenosis-could-it-be-clinically-useful
#10
Concetta Di Nora, Eugenio Cervesato, Iulian Cosei, Andreea Ravasel, Bogdan A Popescu, Concetta Zito, Scipione Carerj, Francesco Antonini-Canterin, Andreea C Popescu
BACKGROUND: In severe aortic stenosis, different left ventricle (LV) remodeling patterns as a response to pressure overload have distinct hemodynamic profiles, cardiac function, and outcomes. The most common classification considers LV relative wall thickness and LV mass index to create 4 different groups. A new classification including also end-diastolic volume index has been recently proposed. AIM: To describe the prevalence of the newly identified remodeling patterns in patients with severe aortic stenosis and to evaluate their clinical relevance according to symptoms...
April 16, 2018: Echocardiography
https://www.readbyqxmd.com/read/29651530/the-requirements-for-low-temperature-plasma-ionization-support-miniaturization-of-the-ion-source
#11
Andreas Kiontke, Frank Holzer, Detlev Belder, Claudia Birkemeyer
Ambient ionization mass spectrometry (AI-MS), the ionization of samples under ambient conditions, enables fast and simple analysis of samples without or with little sample preparation. Due to their simple construction and low resource consumption, plasma-based ionization methods in particular are considered ideal for use in mobile analytical devices. However, systematic investigations that have attempted to identify the optimal configuration of a plasma source to achieve the sensitive detection of target molecules are still rare...
April 13, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29651285/atomic-force-microscopy-of-side-wall-and-septa-peptidoglycan-from-bacillus-subtilis-reveals-an-architectural-remodeling-during-growth
#12
Kang Li, Xiao-Xue Yuan, He-Min Sun, Long-Sheng Zhao, Ruocong Tang, Zhi-Hua Chen, Qi-Long Qin, Xiu-Lan Chen, Yu-Zhong Zhang, Hai-Nan Su
Peptidoglycan is the fundamental structural constituent of the bacterial cell wall. Despite many years of research, the architecture of peptidoglycan is still largely elusive. Here, we report the high-resolution architecture of peptidoglycan from the model Gram-positive bacterium Bacillus subtilis . We provide high-resolution evidence of peptidoglycan architecture remodeling at different growth stages. Side wall peptidoglycan from B. subtilis strain AS1.398 changed from an irregular architecture in exponential growth phase to an ordered cable-like architecture in stationary phase...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29651025/cardiac-eccentric-remodeling-in-patients-with-rheumatoid-arthritis
#13
Valeria Pascale, Rosa Finelli, Rocco Giannotti, Enrico Coscioni, Raffaele Izzo, Francesco Rozza, Dario Caputo, Paolo Moscato, Guido Iaccarino, Michele Ciccarelli
It is known that patients with rheumatoid arthritis (RA) have a higher risk of coronary heart disease and sudden cardiac death. Abnormalities in cardiac geometry appear to be involved in the setting of the cardiovascular risk, but it has never been specifically investigated in RA. We enrolled 44 patients with RA compared to 131 subjects without RA (normal, N): The RA aged between 18 and 70 years (mean 48.3 ± 2.1), 25 females, BMI 27.6 ± 0.9; N, of equal age (48.6 ± 1.2, n.s.), included 80 females (BMI 26...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650365/expression-of-the-human-udp-galactose-transporter-gene-hugt1-in-tobacco-plants-enhanced-plant-hardness
#14
Tayebeh Abedi, Mohamed Farouk Mohamed Khalil, Kanae Koike, Yoshio Hagura, Yuma Tazoe, Nobuhiro Ishida, Kenji Kitamura, Nobukazu Tanaka
We reported previously that tobacco plants transformed with the human UDP-galactose transporter 1 gene (hUGT1) had enhanced growth, displayed characteristic traits, and had an increased proportion of galactose (hyper-galactosylation) in the cell wall matrix polysaccharides. Here, we report that hUGT1-transgenic plants have an enhanced hardness. As determined by breaking and bending tests, the leaves and stems of hUGT1-transgenic plants were harder than those of control plants. Transmission electron microscopy revealed that the cell walls of palisade cells in leaves, and those of cortex cells and xylem fibers in stems of hUGT1-transgenic plants, were thicker than those of control plants...
April 9, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29650237/relation-between-wrist-circumference-and-left-ventricular-structure-in-overweight-children
#15
Simona Zampetti, Giuseppe Campagna, Gaetano Leto, Federica Lucantoni, Luca D'Onofrio, Lidia Marandola, Chiara Moretti, Claudio Chiesa, Lucia Pacifico, Raffaella Buzzetti
The aim of this study was to assess the relation of wrist circumference with changes in left ventricular (LV) structure in a population of overweight/obese children and adolescents. One hundred and six children and adolescents were consecutively enrolled. In all subjects body weight, height, wrist circumference, waist circumference, body mass index-standard deviation score, fasting glucose, insulin, lipid profile, and blood pressure were evaluated. All subjects underwent echocardiographic assessment, and the following parameters were evaluated: LV dimension at end diastole and LV dimension at end systole, LV posterior wall thickness at end diastole and LV posterior wall thickness at end systole, interventricular septal thickness at end diastole and interventricular septal thickness at end systole, LV mass, and epicardial adipose tissue (EAT)...
March 14, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29644236/hypertrophic-cardiomyopathy-with-a-large-apical-ventricular-aneurysm-and-mural-thrombus
#16
Munis Raza, Nagib Chalfoun, Abdallah Wissam, Hamza Hashmi, Richard McNamara
Hypertrophic cardiomyopathy (HCM) is characterized by increased left ventricular wall thickness in the absence of any other identifiable cause of thickness. It predisposes the patient to increased risk of sudden cardiac death (SCD) due to fatal arrhythmias. Approximately 2% of the HCM patients have left ventricular apical aneurysm. CMR imaging is better in identifying this apical aneurysm as compared to echocardiogram. This apical aneurysm, which can be akinetic or dyskinetic, increases the risk of disease-related adverse events as compared to general HCM...
March 14, 2018: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29643968/gastric-wall-thickness-and-stapling-in-laparoscopic-sleeve-gastrectomy-a-literature-review
#17
REVIEW
Krzysztof Barski, Artur Binda, Emilia Kudlicka, Paweł Jaworski, Wiesław Tarnowski
Despite the growing experience of bariatric surgeons in performing laparoscopic sleeve gastrectomy, the number of complications involving staple line leaks remains constant. Hence a solution to avoid such complications is still sought. A defect of the staple line may be the consequence of an inappropriate choice of staple size in relation to gastric wall thickness. Due to the variable nature of gastric wall thickness, the choice of proper staple height is not obvious. In the few studies in which gastric wall thickness was measured, it was observed to decrease gradually from the antrum to the fundus...
March 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29629255/obesity-cardiac-remodeling-and-metabolic-profile-validation-of-a-new-simple-index-beyond-body-mass-index
#18
Francesco Antonini-Canterin, Concetta Di Nora, Stefano Poli, Lina Sparacino, Iulian Cosei, Andreea Ravasel, Andreea Catarina Popescu, Bogdan Alexandru Popescu
Aim: The body mass index (BMI), the most used anthropometric index of obesity, has an important limitation, not taking into consideration the distribution of body fat. We developed a new simple index: the waist-corrected BMI (wBMI), calculated as waist circumference (WC) × BMI. The study aim was to assess the role of wBMI, compared to BMI, WC, and Waist-to-Height Ratio (WHtR) in predicting abnormal cardiac geometry, insulin resistance, increased arterial stiffness, and dyslipidemia. Methods: This was a cross-sectional study that included 805 patients referred to our Department of Preventive Cardiology for risk factors evaluation and treatment...
January 2018: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29625576/skeletal-cardiac-and-respiratory-muscle-function-and-histopathology-in-the-p448lneo-mouse-model-of-fkrp-deficient-muscular-dystrophy
#19
Qing Yu, Melissa Morales, Ning Li, Alexander G Fritz, Ren Ruobing, Anthony Blaeser, Ershia Francois, Qi-Long Lu, Kanneboyina Nagaraju, Christopher F Spurney
BACKGROUND: Fukutin-related protein (FKRP) mutations are the most common cause of dystroglycanopathies known to cause both limb girdle and congenital muscular dystrophy. The P448Lneo- mouse model has a knock-in mutation in the FKRP gene and develops skeletal, respiratory, and cardiac muscle disease. METHODS: We studied the natural history of the P448Lneo- mouse model over 9 months and the effects of twice weekly treadmill running. Forelimb and hindlimb grip strength (Columbus Instruments) and overall activity (Omnitech Electronics) assessed skeletal muscle function...
April 6, 2018: Skeletal Muscle
https://www.readbyqxmd.com/read/29621717/circulating-levels-of-perfluoroalkyl-substances-and-left-ventricular-geometry-of-the-heart-in-the-elderly
#20
Ingrid Mobacke, Lars Lind, Linda Dunder, Samira Salihovic, P Monica Lind
AIMS: Some persistent organic pollutants (POPs) such as hexachlorobenzene (HCB) and some polychlorinated biphenyls (PCBs) have been shown to interfere with myocardial function and geometry. We therefore investigated if also another group of POPs: per- and polyfluoroalkyl substances (PFASs) were associated with alterations in left ventricular geometry. METHODS: 801 subjects aged 70 years were investigated in a cross-sectional study within the scope of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study...
April 2, 2018: Environment International
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