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https://www.readbyqxmd.com/read/28748497/a-large-scale-study-on-the-effects-of-sex-on-gray-matter-asymmetry
#1
Christian Núñez, Constantina Theofanopoulou, Carl Senior, Maria Rosa Cambra, Judith Usall, Christian Stephan-Otto, Gildas Brébion
Research on sex-related brain asymmetries has not yielded consistent results. Despite its importance to further understanding of normal brain development and mental disorders, the field remains relatively unexplored. Here we employ a recently developed asymmetry measure, based on the Dice coefficient, to detect sex-related gray matter asymmetries in a sample of 457 healthy participants (266 men and 191 women) obtained from 5 independent databases. Results show that women's brains are more globally symmetric than men's (p < 0...
July 26, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28748108/readyspeech-for-people-with-dysarthria-after-stroke-protocol-for-a-feasibility-randomised-controlled-trial
#2
Claire Mitchell, Audrey Bowen, Sarah Tyson, Paul Conroy
BACKGROUND: Dysarthria, a disordered speech production resulting from neuro-muscular impairment, is a common symptom after stroke. It causes significant problems for patients' speech intelligibility, communication, psychological well-being, social engagement and stroke recovery. Rehabilitation for dysarthria is variable in quality, intensity and duration, which may be, in part, due to the lack of good quality evidence. An online therapy programme, ReaDySpeech, has the potential to improve quality, intensity and duration of speech rehabilitation and was considered in a proof-of-concept study to be acceptable to speech and language therapists and patients which warranted further evaluation...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28735586/cognitive-development-prior-to-onset-of-psychosis
#3
J Mollon, A Reichenberg
Schizophrenia patients commonly exhibit substantial and diffuse cognitive impairment. Evidence suggests that subtle cognitive deficits are already apparent in childhood and adolescence, many years prior to onset of psychosis. While there is almost unequivocal evidence of some degree of cognitive impairment in individuals who later develop schizophrenia, the literature remains inconclusive regarding the exact nature of this impairment and warrants careful review and interpretation. Meta-analytic findings suggest that individuals who later develop schizophrenia, but not related disorders, such as bipolar disorder, exhibit a premorbid IQ deficit of around 8 points...
July 24, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28729533/common-brain-structure-findings-across-children-with-varied-reading-disability-profiles
#4
Mark A Eckert, Kenneth I Vaden, Amanda B Maxwell, Stephanie L Cute, Mulugeta Gebregziabher, Virginia W Berninger
Dyslexia is a developmental disorder in reading that exhibits varied patterns of expression across children. Here we examined the degree to which different kinds of reading disabilities (defined as profiles or patterns of reading problems) contribute to brain morphology results in Jacobian determinant images that represent local brain shape and volume. A matched-pair brain morphometry approach was used to control for confounding from brain size and research site effects in this retrospective multi-site study of 134 children from eight different research sites...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28727482/atypical-preference-for-infant-directed-speech-as-an-early-marker-of-autism-spectrum-disorders-a-literature-review-and-directions-for-further-research
#5
Marisa G Filipe, Linda Watson, Selene G Vicente, Sónia Frota
Autism spectrum disorders (ASD) refer to a complex group of neurodevelopmental disorders causing difficulties with communication and interpersonal relationships, as well as restricted and repetitive behaviours and interests. As early identification, diagnosis, and intervention provide better long-term outcomes, early markers of ASD have gained increased research attention. This review examines evidence that auditory processing enhanced by social interest, in particular auditory preference of speech directed towards infants and young children (i...
July 20, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28711223/role-of-sexuality-in-body-integrity-identity-disorder-biid-a%C3%A2-cross-sectional-internet-based-survey-study
#6
Rianne M Blom, Sija J van der Wal, Nienke C Vulink, Damiaan Denys
BACKGROUND: Body integrity identity disorder (BIID)-a strong desire for amputation or paralysis-is often accompanied by feelings and cognitions of sexual arousal, although this sexual component has been largely neglected in the recent literature. AIM: To examine the presence of BIID-related sexual arousal in subjects with BIID and explore clinical and demographic variables of subjects with BIID who do and do not possess this sexual arousal. METHODS: Eighty individuals with BIID responded to an internet-based survey we created...
July 13, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28710941/procedural-learning-in-parkinson-s-disease-specific-language-impairment-dyslexia-schizophrenia-developmental-coordination-disorder-and-autism-spectrum-disorders-a-second-order-meta-analysis
#7
Gillian M Clark, Jarrad A G Lum
The serial reaction time task (SRTT) has been used to study procedural learning in clinical populations. In this report, second-order meta-analysis was used to investigate whether disorder type moderates performance on the SRTT. Using this approach to quantitatively summarise past research, it was tested whether autism spectrum disorder, developmental coordination disorder, dyslexia, Parkinson's disease, schizophrenia, and specific language impairment differentially affect procedural learning on the SRTT. The main analysis revealed disorder type moderated SRTT performance (p=0...
October 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28694350/prevalence-of-metabolic-syndrome-discrete-or-comorbid-diabetes-and-hypertension-in-sub-saharan-africa-among-people-living-with-hiv-versus-hiv-negative-populations-a-systematic-review-and-meta-analysis-protocol
#8
Olamide O Todowede, Benn Sartorius
INTRODUCTION: Metabolic disorder and high blood pressure are common complications globally, and specifically among people living with HIV (PLHIV). Diabetes, metabolic syndrome and hypertension are major risk factors for cardiovascular diseases and their related complications. However, the burden of metabolic syndrome, discrete or comorbid diabetes and hypertension in PLHIV compared with HIV-negative population has not been quantified. This review and meta-analysis aims to compare and analyse the prevalence of these trio conditions between HIV-negative and HIV-positive populations in sub-Saharan Africa (SSA)...
July 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28693486/performance-of-international-medical-students-in-psychosocial-medicine
#9
D Huhn, J Lauter, D Roesch Ely, E Koch, A Möltner, W Herzog, F Resch, S C Herpertz, C Nikendei
BACKGROUND: Particularly at the beginning of their studies, international medical students face a number of language-related, social and intercultural challenges. Thus, they perform poorer than their local counterparts in written and oral examinations as well as in Objective Structured Clinical Examinations (OSCEs) in the fields of internal medicine and surgery. It is still unknown how international students perform in an OSCE in the field of psychosocial medicine compared to their local fellow students...
July 10, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28690687/the-role-of-nonverbal-working-memory-in-morphosyntactic-processing-by-children-with-specific-language-impairment-and-autism-spectrum-disorders
#10
Susan Ellis Weismer, Meghan M Davidson, Ishanti Gangopadhyay, Heidi Sindberg, Hettie Roebuck, Margarita Kaushanskaya
BACKGROUND: Both children with autism spectrum disorders (ASD) and children with specific language impairment (SLI) have been shown to have difficulties with grammatical processing. A comparison of these two populations with neurodevelopmental disorders was undertaken to examine similarities and differences in the mechanisms that may underlie grammatical processing. Research has shown that working memory (WM) is recruited during grammatical processing. The goal of this study was to examine morphosyntactic processing on a grammatical judgment task in children who varied in clinical diagnosis and language abilities and to assess the extent to which performance is predicted by nonverbal working memory (WM)...
2017: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/28688078/differences-in-neural-correlates-of-speech-perception-in-3-month-olds-at-high-and-low-risk-for-autism-spectrum-disorder
#11
Laura A Edwards, Jennifer B Wagner, Helen Tager-Flusberg, Charles A Nelson
In this study, we investigated neural precursors of language acquisition as potential endophenotypes of autism spectrum disorder (ASD) in 3-month-old infants at high and low familial ASD risk. Infants were imaged using functional near-infrared spectroscopy while they listened to auditory stimuli containing syllable repetitions; their neural responses were analyzed over left and right temporal regions. While female low risk infants showed initial neural activation that decreased over exposure to repetition-based stimuli, potentially indicating a habituation response to repetition in speech, female high risk infants showed no changes in neural activity over exposure...
July 7, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28672735/safety-concerns-associated-with-second-generation-antipsychotic-long-acting-injection-treatment-a-systematic-update
#12
Salvatore Gentile
Background It has been recently suggested that second-generation antipsychotic long-acting injection (SGA-LAIs) are underutilized in clinical practice, despite that their costs significantly impact on national health system budgets. Hence, an updated analysis of safety data shown by SGA-LAIs may contribute to clarify their role in clinical practice. Materials and methods English-language, peer-reviewed articles reporting updated, primary findings on the SGA-LAI safety were identified (updated through an electronic search of five databases - PubMed, EMBASE, PsycInfo, DARE and the Cochrane Library)...
June 23, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28669318/fronto-subcortical-functional-connectivity-in-patients-with-schizophrenia-and-bipolar-disorder-during-a-verbal-fluency-task
#13
Anaïs Vandevelde, Elise Leroux, Nicolas Delcroix, Sonia Dollfus
OBJECTIVES: Impairments in language production are common of schizophrenia (SZ) and bipolar disorder (BD). Identifying distinct functional connectivity (FC) patterns in SZ and BD may provide biomarkers for their diagnoses. METHODS: 49 participants (15 SZ, 14 BD, and 20 HC) underwent a verbal fluency task consisting of mentally generating verbs in French, alternated with periods of silence. Functional network allowed identifying activation clusters: the medio-frontal cluster (MFC), the left subcortical cluster (LSCC) and the left fronto-lateral cluster (LFLC)...
July 3, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28668259/ayurvedic-anti-diabetic-formulation-lodhrasavam-inhibits-%C3%AE-amylase-and-%C3%AE-glucosidase-suppresses-adipogenic-activity-of-3t3-l1-cells
#14
Megha Abhijit Butala, Subrahmanya Kumar Kukkupuni, Chethala N Vishnuprasad
BACKGROUND: The patho-physiological cross-talk between diabetes and obesity is well established. However, the choices of drugs suitable for combined treatment of diabetes and obesity are limited. Integration of complementary and alternative medicines (CAMs), like Ayurveda, with modern medicine would be a promising strategy to fill this gap. The diagnostic principles of Ayurveda define obesity as one of the predisposing factors of Madhumeha (correlated as diabetes) and recommends specific formulations for managing obese-diabetes...
June 28, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28661580/a-review-of-endophenotypes-in-schizophrenia-and-autism-the-next-phase-for-understanding-genetic-etiologies
#15
Lisabeth F DiLalla, Megan McCrary, Emma Diaz
Many psychiatric disorders are caused by multiple genes and multiple environmental factors, making the identification of specific genetic risk factors for these disorders difficult. Endophenotypes are behaviors or characteristics that are intermediate between the genotype and a phenotype of interest. Because they are more directly related to the gene action than is the endpoint disorder, they may be useful in the identification of specific genes related to psychiatric disorders and the classification of disorders or traits that share an underlying genetic etiology...
June 29, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28656659/multidisciplinary-biopsychosocial-rehabilitation-for-subacute-low-back-pain
#16
REVIEW
Teresa J Marin, Dwayne Van Eerd, Emma Irvin, Rachel Couban, Bart W Koes, Antti Malmivaara, Maurits W van Tulder, Steven J Kamper
BACKGROUND: Low back pain (LBP) is associated with enormous personal and societal burdens, especially when it reaches the chronic stage of the disorder (pain for a duration of more than three months). Indeed, individuals who reach the chronic stage tend to show a more persistent course, and they account for the majority of social and economic costs. As a result, there is increasing emphasis on the importance of intervening at the early stages of LBP.According to the biopsychosocial model, LBP is a condition best understood with reference to an interaction of physical, psychological, and social influences...
June 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28654601/nonsyndromic-craniosynostosis-and-associated-abnormal-speech-and-language-development
#17
Sanjay Naran, Matthew Miller, Sameer Shakir, Benjamin Ware, Liliana Camison, Matthew Ford, Jesse Goldstein, Joseph E Losee
BACKGROUND: Although many metrics for neurodevelopment in children with nonsyndromic craniosynostosis have been analyzed, few have directly examined early language acquisition and speech development. The authors characterized language acquisition and speech development in children with nonsyndromic craniosynostosis. METHODS: The authors' institutional database was queried for nonsyndromic craniosynostosis from 2000 to 2014. Patients with an identified syndrome were excluded...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28653647/advances-in-progressive-supranuclear-palsy-new-diagnostic-criteria-biomarkers-and-therapeutic-approaches
#18
REVIEW
Adam L Boxer, Jin-Tai Yu, Lawrence I Golbe, Irene Litvan, Anthony E Lang, Günter U Höglinger
Progressive supranuclear palsy (PSP), previously believed to be a common cause of atypical parkinsonism, is now recognised as a range of motor and behavioural syndromes that are associated with a characteristic 4-repeat tau neuropathology. New research criteria that recognise early presentations of PSP and operationalise diagnosis of the full spectrum of clinical phenotypes have been reported. The Movement Disorders Society PSP diagnostic criteria include syndromes with few or mild symptoms that are suggestive of underlying PSP pathology and could provide an opportunity for earlier therapeutic interventions in the future...
July 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28645298/neurodevelopmental-profile-of-fetal-alcohol-spectrum-disorder-a-systematic-review
#19
Shannon Lange, Joanne Rovet, Jürgen Rehm, Svetlana Popova
BACKGROUND: In an effort to improve the screening and diagnosis of individuals with Fetal Alcohol Spectrum Disorder (FASD), research has focused on the identification of a unique neurodevelopmental profile characteristic of this population. The objective of this review was to identify any existing neurodevelopmental profiles of FASD and review their classification function in order to identify gaps and limitations of the current literature. METHODS: A systematic search for studies published up to the end of December 2016 reporting an identified neurodevelopmental profile of FASD was conducted using multiple electronic bibliographic databases...
June 23, 2017: BMC Psychology
https://www.readbyqxmd.com/read/28645156/rem-sleep-behavior-disorder-and-cognitive-impairment-in-parkinson-s-disease
#20
Natalia Jozwiak, Ronald B Postuma, Jacques Montplaisir, Véronique Latreille, Michel Panisset, Sylvain Chouinard, Pierre-Alexandre Bourgouin, Jean-François Gagnon
Study Objectives: REM sleep behavior disorder (RBD) is a parasomnia affecting 33 to 46% of patients with Parkinson's disease (PD). The existence of a unique and specific impaired cognitive profile in PD patients with RBD is still controversial. We extensively assessed cognitive functions to identify whether RBD is associated with more severe cognitive deficits in nondemented patients with PD. Methods: One hundred and sixty-two participants, including 53 PD patients with RBD, 40 PD patients without RBD, and 69 healthy subjects, underwent polysomnography, a neurological assessment, and an extensive neuropsychological exam to assess attention, executive functions, episodic learning and memory, visuospatial abilities, and language...
June 22, 2017: Sleep
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