keyword
MENU ▼
Read by QxMD icon Read
search

Toll like receptors and thyroid

keyword
https://www.readbyqxmd.com/read/29656212/myeloid-related-proteins-are-up-regulated-in-autoimmune-thyroid-diseases-and-activate-toll-like-receptor-4-and-pro-inflammatory-cytokines-in-vitro
#1
Shiqiao Peng, Xuren Sun, Xinyi Wang, Haoyu Wang, Zhongyan Shan, Weiping Teng, Chenyan Li
PURPOSE: Myeloid-related protein (MRP) family plays an important role in the promotion of cell proliferation and the production of inflammatory cytokines. We investigated the expression of MRP6, MRP8 and MRP14 in thyroid tissues, serum, and peripheral blood monocular cells (PBMCs) in patients with autoimmune thyroid diseases (AITD). METHOD: The expression of MRP6, MRP8, and MRP14 was investigated using immunohistochemical staining and quantitative real-time polymerase chain reaction in the thyroid glands of 7 patients with Graves' disease (GD), 8 with Hashimoto's thyroiditis (HT), and 7 healthy controls (HC)...
April 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29523762/functional-toll-like-receptor-4-overexpression-in-papillary-thyroid-cancer-by-mapk-erk-induced-ets1-transcriptional-activity
#2
Victoria Peyret, Magalí Nazar, Mariano Martin, Amado A Quintar, Elmer A Fernandez, Romina C Geysels, Cesar Fuziwara, María M Montesinos, Cristina A Maldonado, Pilar Santisteban, Edna T Kimura, Claudia G Pellizas, Juan P Nicola, Ana M Masini-Repiso
Emerging evidence suggests that unregulated Toll-like receptors (TLRs) signaling promotes tumor survival signals, thus favoring tumor progression. Here, the mechanism underlying TLR4 overexpression in papillary thyroid carcinomas (PTCs) mainly harboring the BRAFV600E mutation was studied. TLR4 was overexpressed in PTCs compared to non-neoplastic thyroid tissue. Moreover, paired clinical specimens of primary PTC and its lymph node metastasis showed a significant upregulation of TLR4 levels in the metastatic tissues...
March 9, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29483584/localization-of-lipopolysaccharide-from-escherichia-coli-into-human-atherosclerotic-plaque
#3
Roberto Carnevale, Cristina Nocella, Vincenzo Petrozza, Vittoria Cammisotto, Luca Pacini, Veronica Sorrentino, Ombretta Martinelli, Luigi Irace, Sebastiano Sciarretta, Giacomo Frati, Daniele Pastori, Francesco Violi
Experimental studies showed that gut-derived lipopolysaccharide (LPS) is pro-atherogenic, however, its relationship with human atherosclerosis is still to be defined. We investigate if gut-derived LPS from Escherichia Coli localizes in human carotid plaque and its potential role as pro-inflammatory molecule in the atherosclerotic lesion. LPS from Escherichia Coli and Toll-like receptor 4 (TLR4) were studied in specimens from carotid and thyroid arteries of 10 patients undergoing endarterectomy and 15 controls matched for demographic and clinical characteristics...
February 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29407432/thyroid-autoimmunity-an-interplay-of-factors
#4
Stephen J Merrill, Sarah B Minucci
The literature on thyroid autoimmunity has identified many potential factors at play for the initiation and progression of autoimmune thyroid diseases. These factors include genetic susceptibility, environmental factors, some drugs, iodine and selenium, infection, molecular mimics, and immune system defects. The sheer number of feasible factors makes sorting out the necessary agents from the fellow travelers difficult. In addition, many of these factors have the capability to interact-further confusing the picture...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/28912808/association-of-polymorphisms-in-toll-like-receptors-4-and-9-with-autoimmune-thyroid-disease-in-korean-pediatric-patients
#5
Won Kyoung Cho, Jung-Pil Jang, Eun-Jeong Choi, Moonbae Ahn, Shin Hee Kim, Kyoung Soon Cho, So Hyun Park, In Cheol Baek, Min Ho Jung, Tai-Gyu Kim, Byung-Kyu Suh
BACKGROUND: Toll-like receptors (TLRs) have been suggested to be associated with the development of AITD. METHODS: Fifteen single-nucleotide polymorphisms in 7 TLR genes were analyzed in 104 Korean children (girls = 86, boys = 18) with AITD (Hashimoto disease (HD) = 44, Graves' disease (GD) = 60, thyroid-associated ophthalmopathy (TAO) = 29, and non-TAO = 31) with 183 controls. RESULTS: GD showed higher frequencies of the TLR4 rs1927911 C allele than control...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28515728/corrigendum-increased-toll-like-receptors-activity-and-tlr-ligands-in-patients-with-autoimmune-thyroid-diseases
#6
Shiqiao Peng, Chenyan Li, Xinyi Wang, Xin Liu, Cheng Han, Ting Jin, Shanshan Liu, Xiaowen Zhang, Hanyi Zhang, Xue He, Xiaochen Xie, Xiaohui Yu, Chuyuan Wang, Ling Shan, Chenling Fan, Zhongyan Shan, Weiping Teng
[This corrects the article on p. 578 in vol. 7, PMID: 28018345.].
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28428828/bioinformatics-analysis-of-key-genes-and-latent-pathway-interactions-based-on-the-anaplastic-thyroid-carcinoma-gene-expression-profile
#7
Yun Huang, Yiming Tao, Xinying Li, Shi Chang, Bo Jiang, Feng Li, Zhi-Ming Wang
Anaplastic thyroid carcinoma (ATC) is an aggressive malignant disease in older adults with a high mortality rate. The present study aimed to examine several key genes and pathways, which are associated with ATC. The GSE33630 gene expression profile was downloaded from the Gene Expression Omnibus database, which included 11 ATC and 45 normal thyroid samples. The differentially expressed genes (DEGs) in ATC were identified using the Limma package in R. The Gene Ontology functions and Kyoto Encyclopedia of Genes and Genomes pathways of the selected DEGs were enriched using the Database for Annotation, Visualization and Integrated Discovery...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28018345/increased-toll-like-receptors-activity-and-tlr-ligands-in-patients-with-autoimmune-thyroid-diseases
#8
Shiqiao Peng, Chenyan Li, Xinyi Wang, Xin Liu, Cheng Han, Ting Jin, Shanshan Liu, Xiaowen Zhang, Hanyi Zhang, Xue He, Xiaochen Xie, Xiaohui Yu, Chuyuan Wang, Ling Shan, Chenling Fan, Zhongyan Shan, Weiping Teng
OBJECTIVE: Autoimmune thyroid disease (AITD) is an organ-specific disorder due to the interplay between environmental and genetic factors. Toll-like receptors (TLRs) are pattern recognition receptors expressed abundantly on monocytes. There is a paucity of data on TLR expression in AITD. The aim of this study was to examine TLR expression, activation, ligands, and downstream signaling adaptors in peripheral blood mononuclear cells (PBMCs) extracted from untreated AITD patients and healthy controls...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/28013570/polymorphisms-and-expression-of-toll-like-receptors-in-autoimmune-thyroid-diseases
#9
Naoya Inoue, Yuka Katsumata, Mikio Watanabe, Naoko Ishido, Yu Manabe, Ayano Watanabe, Ryota Masutani, Yoh Hidaka, Yoshinori Iwatani
Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid diseases (AITDs). Prognosis of AITDs varies in each patient. Toll-like receptors (TLRs) are pattern-recognition receptors that activate signaling pathways involved in the production of proinflammatory cytokines. UNC93B1 is a transcription factor of TLR7 and TLR9. In this study, we examined the association of TLR expression and TLR and UNC93B1 polymorphisms with the development and prognosis of AITDs. The ratio of intracellular TLR7 (iTLR7) and iTLR9 intensities in B cells was lower in patients with GD in remission than in patients with intractable GD (p = 0...
December 26, 2016: Autoimmunity
https://www.readbyqxmd.com/read/27497785/identification-of-interacting-proteins-with-aryl-hydrocarbon-receptor-in-scallop-chlamys-farreri-by-yeast-two-hybrid-screening
#10
Yuefeng Cai, Luqing Pan, Jingjing Miao, Tong Liu
The aryl hydrocarbon receptor (AhR) belongs to the basic-helix-loop helix (bHLH) Per-Arnt-Sim (PAS) family of transcription factors. AhR has been known primarily for its role in the regulation of several drug and xenobiotic metabolizing enzymes, as well as the mediation of the toxicity of certain xenobiotics, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Although the AhR is well-studied as a mediator of the toxicity of certain xenobiotics in marine bivalves, the normal physiological function remains unknown...
November 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27375623/peptidylarginine-deiminase-inhibitor-suppresses-neutrophil-extracellular-trap-formation-and-mpo-anca-production
#11
Yoshihiro Kusunoki, Daigo Nakazawa, Haruki Shida, Fumihiko Hattanda, Arina Miyoshi, Sakiko Masuda, Saori Nishio, Utano Tomaru, Tatsuya Atsumi, Akihiro Ishizu
Myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis is a systemic small-vessel vasculitis, wherein, MPO-ANCA plays a critical role in the pathogenesis. Neutrophil extracellular traps (NETs) released from activated neutrophils are composed of extracellular web-like DNA and antimicrobial proteins, including MPO. Diverse stimuli, such as phorbol myristate acetate (PMA) and ligands of toll-like receptors (TLR), induce NETs. Although TLR-mediated NET formation can occur with preservation of living neutrophilic functions (called vital NETosis), PMA-stimulated neutrophils undergo cell death with NET formation (called suicidal NETosis)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/26963519/thyroid-active-agents-t3-and-ptu-differentially-affect-immune-gene-transcripts-in-the-head-kidney-of-rainbow-trout-oncorynchus-mykiss
#12
Alba Quesada-García, Paloma Encinas, Ana Valdehita, Lisa Baumann, Helmut Segner, Julio M Coll, José M Navas
In mammals, numerous reports describe an immunomodulating effect of thyroid-active compounds. In contrast, only few reports have been published on this subject in fish. We previously demonstrated that immune cells of rainbow trout (Oncorhynchus mykiss) possess thyroid hormone receptors (THRs) and that exposure of trout to the thyroid hormone 3,3',5-triiodo-l-thyronine (T3) or the antithyroid drug propylthiouracil (PTU) alters immune cell transcript levels of THR and several immune genes. The present study aims to further characterize the immunomodulating action of thyroid-active compounds in trout immune cells...
May 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/26678064/a-novel-analysis-strategy-for-integrating-methylation-and-expression-data-reveals-core-pathways-for-thyroid-cancer-aetiology
#13
COMPARATIVE STUDY
Bugra Ozer, Osman Uğur Sezerman
BACKGROUND: Recently, a wide range of diseases have been associated with changes in DNA methylation levels, which play a vital role in gene expression regulation. With ongoing developments in technology, attempts to understand disease mechanism have benefited greatly from epigenetics and transcriptomics studies. In this work, we have used expression and methylation data of thyroid carcinoma as a case study and explored how to optimally incorporate expression and methylation information into the disease study when both data are available...
2015: BMC Genomics
https://www.readbyqxmd.com/read/26177832/kupffer-cell-mediated-exacerbation-of-methimazole-induced-acute-liver-injury-in-rats
#14
Sho Akai, Yasuaki Uematsu, Koichi Tsuneyama, Shingo Oda, Tsuyoshi Yokoi
Methimazole (MTZ), an anti-thyroid drug, is known to cause liver injury in humans. It has been demonstrated that MTZ-induced liver injury in Balb/c mice is accompanied by T helper (Th) 2 cytokine-mediated immune responses; however, there is little evidence for immune responses associated with MTZ-induced liver injury in rats. To investigate species differences in MTZ-induced liver injury, we administered MTZ with a glutathione biosynthesis inhibitor, L-buthionine-S,R-sulfoximine (BSO), to F344 rats and subsequently observed an increase in plasma alanine aminotransferase (ALT) and high-mobility group box 1 (HMGB1), which are associated with hepatic lesions...
May 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/25674762/aberrant-expression-of-cot-is-related-to-recurrence-of-papillary-thyroid-cancer
#15
Jandee Lee, Seonhyang Jeong, Jae Hyun Park, Cho Rok Lee, Cheol Ryong Ku, Sang-Wook Kang, Jong Ju Jeong, Kee-Hyun Nam, Dong Yeob Shin, Eun Jig Lee, Woong Youn Chung, Young Suk Jo
Aberrant expression of Cancer Osaka Thyroid Oncogene mitogen-activated protein kinase kinase kinase 8 (COT) (MAP3K8) is a driver of resistance to B-RAF inhibition. However, the de novo expression and clinical implications of COT in papillary thyroid cancer (PTC) have not been investigated.The aim of this study is to investigate the expression of A-, B-, C-RAF, and COT in PTC (n = 167) and analyze the clinical implications of aberrant expression of these genes.Quantitative polymerase chain reaction (qPCR) and immunohistochemical staining (IHC) were performed on primary thyroid cancers...
February 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25576242/thyroid-autoimmunity-as-a-window-to-autoimmunity-an-explanation-for-sex-differences-in-the-prevalence-of-thyroid-autoimmunity
#16
Stephen J Merrill, Ying Mu
Autoimmune thyroid diseases (AITDs), predominately Graves׳ disease and Hashimoto׳s thyroiditis, comprise the most common autoimmune diseases in humans. Both have the production of anti-thyroid antibody as an important aspect and both are much more prevalent in females, being at least 10 times more common than in males. Using these two clues, a hypothesis for the initiation of thyroid autoimmunity is proposed that helps to make the case that the thyroid is one of the most sensitive sites for autoimmunity and helps account for the prevalence and the observed sex differences in AITDs and associated diseases, such as type 1 diabetes and Latent Autoimmune Diabetes in Adults (LADA)...
June 21, 2015: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/25295614/association-of-toll-like-receptor-10-polymorphisms-with-autoimmune-thyroid-disease-in-korean-children
#17
Won Kyoung Cho, Jung-Pil Jang, Eun-Jeong Choi, Yeon Jin Jeon, In Ah Jung, Shin-Hee Kim, Min Ho Jung, Tai-Gyu Kim, Byung-Kyu Suh
BACKGROUND: The Toll-like receptors (TLRs) are germline-encoded receptors that play an essential role in initiating the immune response against pathogens. In this study, we assess the association of TLR polymorphism with autoimmune thyroid disease (AITD) in Korean children. METHODS: We investigated three polymorphisms in the TLR10 gene (rs4129009, rs11096956, and rs10004195) in 85 Korean AITD patients (Graves' disease, [GD]=50, Hashimoto's disease [HD]=35; thyroid-associated ophthalmopathy [TAO]=23, non-TAO=62; male=16, female=69; mean age=13...
February 2015: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/24666275/the-effect-of-types-i-and-iii-interferons-on-adrenocortical-cells-and-its-possible-implications-for-autoimmune-addison-s-disease
#18
A Hellesen, K Edvardsen, L Breivik, E S Husebye, E Bratland
Autoimmune Addison's disease (AAD) is caused by selective destruction of the hormone-producing cells of the adrenal cortex. As yet, little is known about the potential role played by environmental factors in this process. Type I and/or type III interferons (IFNs) are signature responses to virus infections, and have also been implicated in the pathogenesis of autoimmune endocrine disorders such as type 1 diabetes and autoimmune thyroiditis. Transient development of AAD and exacerbation of established or subclinical disease, as well as the induction of autoantibodies associated with AAD, have been reported following therapeutic administration of type I IFNs...
June 2014: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/24625920/the-effects-of-subclinical-hypothyroidism-on-serum-lipid-level-and-tlr4-expression-of-monocyte-in-peripheral-blood-of-rats
#19
Shuan-suo Yang, Lei Tang, Ruo-gu Li, Guang-hao Ge, Xin-kai Qu, Jiang-wei Ma, Zeng-yong Qiao, Li Zhang, Hua-jin Liu, Yue-mei Hou, Hua Cao, Zhi-min Hao, Wen-bo Cheng, Hong-wei Wang
OBJECTIVE: To observe effect of subclinical hypothyroidism (SCH) on serum lipid level and expression of toll-like receptor 4 (TLR4) in rats' peripheral blood mononuclear cells (PBMC). METHODS: Fifty Wistar female rats were divided into three groups: normal control (NC group; n=10), sham group (n=10), and L-T-4 (L-thyroxine) group (n=30, with thyroidectomy, fed with rich-calcium water after operation. 5 weeks later, abdominal subcutaneous injection of L-T-4: 0.95 μg/100g/d)...
2014: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/24534949/maternal-thyroid-dysfunction-affects-placental-profile-of-inflammatory-mediators-and-the-intrauterine-trophoblast-migration-kinetics
#20
COMPARATIVE STUDY
Juneo Freitas Silva, Natália Melo Ocarino, Rogéria Serakides
The objective of the present study was to evaluate the gene and immunohistochemical expression of inflammatory mediators involved in the immune activity and the intrauterine trophoblast migration of the placentas in hypothyroid and L-thyroxine (L-T4)-treated rats. A total of 144 adult female rats were divided equally into hypothyroid, l-T4-treated, and euthyroid (control) groups. Hypothyroidism was induced by daily administration of propylthiouracil. Rats were killed at 0, 10, 14, 15, 16, 17, 18, and 19 days of gestation...
June 2014: Reproduction: the Official Journal of the Society for the Study of Fertility
keyword
keyword
39191
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"