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Toll like receptors and thyroid

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https://www.readbyqxmd.com/read/27497785/identification-of-interacting-proteins-with-aryl-hydrocarbon-receptor-in-scallop-chlamys-farreri-by-yeast-two-hybrid-screening
#1
Yuefeng Cai, Luqing Pan, Jingjing Miao, Tong Liu
The aryl hydrocarbon receptor (AhR) belongs to the basic-helix-loop helix (bHLH) Per-Arnt-Sim (PAS) family of transcription factors. AhR has been known primarily for its role in the regulation of several drug and xenobiotic metabolizing enzymes, as well as the mediation of the toxicity of certain xenobiotics, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Although the AhR is well-studied as a mediator of the toxicity of certain xenobiotics in marine bivalves, the normal physiological function remains unknown...
November 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27375623/peptidylarginine-deiminase-inhibitor-suppresses-neutrophil-extracellular-trap-formation-and-mpo-anca-production
#2
Yoshihiro Kusunoki, Daigo Nakazawa, Haruki Shida, Fumihiko Hattanda, Arina Miyoshi, Sakiko Masuda, Saori Nishio, Utano Tomaru, Tatsuya Atsumi, Akihiro Ishizu
Myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis is a systemic small-vessel vasculitis, wherein, MPO-ANCA plays a critical role in the pathogenesis. Neutrophil extracellular traps (NETs) released from activated neutrophils are composed of extracellular web-like DNA and antimicrobial proteins, including MPO. Diverse stimuli, such as phorbol myristate acetate (PMA) and ligands of toll-like receptors (TLR), induce NETs. Although TLR-mediated NET formation can occur with preservation of living neutrophilic functions (called vital NETosis), PMA-stimulated neutrophils undergo cell death with NET formation (called suicidal NETosis)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/26963519/thyroid-active-agents-t3-and-ptu-differentially-affect-immune-gene-transcripts-in-the-head-kidney-of-rainbow-trout-oncorynchus-mykiss
#3
Alba Quesada-García, Paloma Encinas, Ana Valdehita, Lisa Baumann, Helmut Segner, Julio M Coll, José M Navas
In mammals, numerous reports describe an immunomodulating effect of thyroid-active compounds. In contrast, only few reports have been published on this subject in fish. We previously demonstrated that immune cells of rainbow trout (Oncorhynchus mykiss) possess thyroid hormone receptors (THRs) and that exposure of trout to the thyroid hormone 3,3',5-triiodo-l-thyronine (T3) or the antithyroid drug propylthiouracil (PTU) alters immune cell transcript levels of THR and several immune genes. The present study aims to further characterize the immunomodulating action of thyroid-active compounds in trout immune cells...
May 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/26678064/a-novel-analysis-strategy-for-integrating-methylation-and-expression-data-reveals-core-pathways-for-thyroid-cancer-aetiology
#4
COMPARATIVE STUDY
Bugra Ozer, Osman Uğur Sezerman
BACKGROUND: Recently, a wide range of diseases have been associated with changes in DNA methylation levels, which play a vital role in gene expression regulation. With ongoing developments in technology, attempts to understand disease mechanism have benefited greatly from epigenetics and transcriptomics studies. In this work, we have used expression and methylation data of thyroid carcinoma as a case study and explored how to optimally incorporate expression and methylation information into the disease study when both data are available...
2015: BMC Genomics
https://www.readbyqxmd.com/read/26177832/kupffer-cell-mediated-exacerbation-of-methimazole-induced-acute-liver-injury-in-rats
#5
Sho Akai, Yasuaki Uematsu, Koichi Tsuneyama, Shingo Oda, Tsuyoshi Yokoi
Methimazole (MTZ), an anti-thyroid drug, is known to cause liver injury in humans. It has been demonstrated that MTZ-induced liver injury in Balb/c mice is accompanied by T helper (Th) 2 cytokine-mediated immune responses; however, there is little evidence for immune responses associated with MTZ-induced liver injury in rats. To investigate species differences in MTZ-induced liver injury, we administered MTZ with a glutathione biosynthesis inhibitor, L-buthionine-S,R-sulfoximine (BSO), to F344 rats and subsequently observed an increase in plasma alanine aminotransferase (ALT) and high-mobility group box 1 (HMGB1), which are associated with hepatic lesions...
May 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/25674762/aberrant-expression-of-cot-is-related-to-recurrence-of-papillary-thyroid-cancer
#6
Jandee Lee, Seonhyang Jeong, Jae Hyun Park, Cho Rok Lee, Cheol Ryong Ku, Sang-Wook Kang, Jong Ju Jeong, Kee-Hyun Nam, Dong Yeob Shin, Eun Jig Lee, Woong Youn Chung, Young Suk Jo
Aberrant expression of Cancer Osaka Thyroid Oncogene mitogen-activated protein kinase kinase kinase 8 (COT) (MAP3K8) is a driver of resistance to B-RAF inhibition. However, the de novo expression and clinical implications of COT in papillary thyroid cancer (PTC) have not been investigated.The aim of this study is to investigate the expression of A-, B-, C-RAF, and COT in PTC (n = 167) and analyze the clinical implications of aberrant expression of these genes.Quantitative polymerase chain reaction (qPCR) and immunohistochemical staining (IHC) were performed on primary thyroid cancers...
February 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25576242/thyroid-autoimmunity-as-a-window-to-autoimmunity-an-explanation-for-sex-differences-in-the-prevalence-of-thyroid-autoimmunity
#7
Stephen J Merrill, Ying Mu
Autoimmune thyroid diseases (AITDs), predominately Graves׳ disease and Hashimoto׳s thyroiditis, comprise the most common autoimmune diseases in humans. Both have the production of anti-thyroid antibody as an important aspect and both are much more prevalent in females, being at least 10 times more common than in males. Using these two clues, a hypothesis for the initiation of thyroid autoimmunity is proposed that helps to make the case that the thyroid is one of the most sensitive sites for autoimmunity and helps account for the prevalence and the observed sex differences in AITDs and associated diseases, such as type 1 diabetes and Latent Autoimmune Diabetes in Adults (LADA)...
June 21, 2015: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/25295614/association-of-toll-like-receptor-10-polymorphisms-with-autoimmune-thyroid-disease-in-korean-children
#8
Won Kyoung Cho, Jung-Pil Jang, Eun-Jeong Choi, Yeon Jin Jeon, In Ah Jung, Shin-Hee Kim, Min Ho Jung, Tai-Gyu Kim, Byung-Kyu Suh
BACKGROUND: The Toll-like receptors (TLRs) are germline-encoded receptors that play an essential role in initiating the immune response against pathogens. In this study, we assess the association of TLR polymorphism with autoimmune thyroid disease (AITD) in Korean children. METHODS: We investigated three polymorphisms in the TLR10 gene (rs4129009, rs11096956, and rs10004195) in 85 Korean AITD patients (Graves' disease, [GD]=50, Hashimoto's disease [HD]=35; thyroid-associated ophthalmopathy [TAO]=23, non-TAO=62; male=16, female=69; mean age=13...
February 2015: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/24666275/the-effect-of-types-i-and-iii-interferons-on-adrenocortical-cells-and-its-possible-implications-for-autoimmune-addison-s-disease
#9
A Hellesen, K Edvardsen, L Breivik, E S Husebye, E Bratland
Autoimmune Addison's disease (AAD) is caused by selective destruction of the hormone-producing cells of the adrenal cortex. As yet, little is known about the potential role played by environmental factors in this process. Type I and/or type III interferons (IFNs) are signature responses to virus infections, and have also been implicated in the pathogenesis of autoimmune endocrine disorders such as type 1 diabetes and autoimmune thyroiditis. Transient development of AAD and exacerbation of established or subclinical disease, as well as the induction of autoantibodies associated with AAD, have been reported following therapeutic administration of type I IFNs...
June 2014: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/24625920/the-effects-of-subclinical-hypothyroidism-on-serum-lipid-level-and-tlr4-expression-of-monocyte-in-peripheral-blood-of-rats
#10
Shuan-suo Yang, Lei Tang, Ruo-gu Li, Guang-hao Ge, Xin-kai Qu, Jiang-wei Ma, Zeng-yong Qiao, Li Zhang, Hua-jin Liu, Yue-mei Hou, Hua Cao, Zhi-min Hao, Wen-bo Cheng, Hong-wei Wang
OBJECTIVE: To observe effect of subclinical hypothyroidism (SCH) on serum lipid level and expression of toll-like receptor 4 (TLR4) in rats' peripheral blood mononuclear cells (PBMC). METHODS: Fifty Wistar female rats were divided into three groups: normal control (NC group; n=10), sham group (n=10), and L-T-4 (L-thyroxine) group (n=30, with thyroidectomy, fed with rich-calcium water after operation. 5 weeks later, abdominal subcutaneous injection of L-T-4: 0.95 μg/100g/d)...
2014: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/24534949/maternal-thyroid-dysfunction-affects-placental-profile-of-inflammatory-mediators-and-the-intrauterine-trophoblast-migration-kinetics
#11
COMPARATIVE STUDY
Juneo Freitas Silva, Natália Melo Ocarino, Rogéria Serakides
The objective of the present study was to evaluate the gene and immunohistochemical expression of inflammatory mediators involved in the immune activity and the intrauterine trophoblast migration of the placentas in hypothyroid and L-thyroxine (L-T4)-treated rats. A total of 144 adult female rats were divided equally into hypothyroid, l-T4-treated, and euthyroid (control) groups. Hypothyroidism was induced by daily administration of propylthiouracil. Rats were killed at 0, 10, 14, 15, 16, 17, 18, and 19 days of gestation...
June 2014: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/24363762/stimulation-of-tlr4-by-lmw-ha-induces-metastasis-in-human-papillary-thyroid-carcinoma-through-cxcr7
#12
Shipeng Dang, Yongde Peng, Lei Ye, Yanan Wang, Zhongqing Qian, Yuqing Chen, Xiaojing Wang, Yunzhi Lin, Xiaomei Zhang, Xiyan Sun, Qiong Wu, Yiji Cheng, Hong Nie, Min Jin, Huanbai Xu
In inflammatory sites, high molecular weight hyaluronan fragments are degraded into lower molecular weight hyaluronan fragments (LMW-HA) to regulate immune responses. However, the function of LMW-HA in PTC progression remains to be elucidated. In this study, we found that receptor of LMW-HA, TLR4, was aberrantly overexpressed in PTC tissues and cell line W3. Exposure of W3 cells to LMW-HA promoted cell proliferation and migration via TLR4. Knockdown of TLR4 has provided evidence that TLR4 is essential for LMW-HA-induced CXCR7 expression, which is responsible for LMW-HA-induced proliferation and migration of W3 cells...
2013: Clinical & Developmental Immunology
https://www.readbyqxmd.com/read/24176535/polymorphism-of-toll-like-receptor-4-gene-in-bipolar-disorder
#13
José Oliveira, Marc Busson, Bruno Etain, Stéphane Jamain, Nora Hamdani, Wahid Boukouaci, Kahina Amokrane, Mériem Bennabi, Emmanuel Le Guen, Aroldo Ayub Dargél, Josselin Houenou, Rayna Ivanova, Frank Bellivier, Chantal Henry, Jean-Pierre Kahn, Dominique Charron, Rajagopal Krishnamoorthy, Laetitia Vervoitte, Marion Leboyer, Ryad Tamouza
BACKGROUND: Bipolar disorder (BD) is considered as a multifactorial disorder involving complex interactions between genetic and environmental factors, where immune dysfunction is thought to play a key etiopathogenic role. In particular, excess of winter births associated with early-life infections raise the possibility of the implication of innate immunity. Given the pivotal role of Toll-like receptor 4 (TLR-4), a major innate immune sensor molecule, we hypothesized that genetic variations of TLR-4 may be associated to BD...
January 2014: Journal of Affective Disorders
https://www.readbyqxmd.com/read/24069456/a-tnf-variant-that-associates-with-susceptibility-to-musculoskeletal-disease-modulates-thyroid-hormone-receptor-binding-to-control-promoter-activation
#14
Endre Kiss-Toth, Edward Harlock, Darren Lath, Thomas Quertermous, J Mark Wilkinson
Tumor necrosis factor (TNF) is a powerful pro-inflammatory cytokine and immuno-regulatory molecule, and modulates susceptibility to musculoskeletal diseases. Several meta-analyses and replicated association studies have implicated the minor 'A' variant within the TNF promoter single nucleotide polymorphism (SNP) rs361525 (-238A/G) as a risk allele in joint related disorders, including psoriatic and juvenile idiopathic arthritis, and osteolysis after joint arthroplasty. Here we characterized the effect of this variant on TNF promoter function...
2013: PloS One
https://www.readbyqxmd.com/read/23422193/polyinosine-polycytidylic-acid-promotes-excessive-iodine-intake-induced-thyroiditis-in-non-obese-diabetic-mice-via-toll-like-receptor-3-mediated-inflammation
#15
Ya-nan Shi, Feng-hua Liu, Xiu-jie Yu, Ze-bing Liu, Qing-xin Li, Ji-hong Yuan, Xiao-yi Zang, Lan-ying Li
BACKGROUND: Excessive iodine intake and viral infection are recognized as both critical factors associated with autoimmune thyroid diseases. Toll-like receptors (TLRs) have been reported to play an important role in autoimmune and inflammatory disorders. In this study, we aimed to clarify the possible mechanism of TLR3 involved in polyinosine-polycytidylic acid (poly(I:C)) promoting excessive iodine intake induced thyroiditis in non-obese diabetic (NOD) mice. METHODS: Both NOD and BALB/c mice were randomly assigned to four groups: control group (n = 5), high iodine intake (HI) group (n = 7), poly(I:C) group (n = 7) and combination of excessive iodine and poly(I:C) injection (HIP) group (n = 7)...
February 2013: Chinese Medical Journal
https://www.readbyqxmd.com/read/23234343/demonstration-of-innate-immune-responses-in-the-thyroid-gland-potential-to-sense-danger-and-a-possible-trigger-for-autoimmune-reactions
#16
Akira Kawashima, Kazuko Yamazaki, Takeshi Hara, Takeshi Akama, Aya Yoshihara, Mariko Sue, Kazunari Tanigawa, Huhehasi Wu, Yuko Ishido, Fumihiko Takeshita, Norihisa Ishii, Kanji Sato, Koichi Suzuki
BACKGROUND: Autoimmune thyroid disease is an archetypal organ-specific autoimmune disorder that is characterized by the production of thyroid autoantibodies and lymphocytic infiltration into the thyroid. However, the underlying mechanisms by which specific thyroid antibodies are produced are largely unknown. Recent studies have shown that innate immune responses affect both the phenotype and the severity of autoimmune reactions. Moreover, it appears that even non-immune cells, including thyroid cells, have an ability to launch such responses...
April 2013: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/23200063/does-the-gut-microbiota-trigger-hashimoto-s-thyroiditis
#17
REVIEW
Kouki Mori, Yoshinori Nakagawa, Hiroshi Ozaki
Hashimoto's thyroiditis is an organ-specific autoimmune disease in which both genetic predisposition and environmental factors serve as the trigger of the disease. A growing body of evidence suggests involvement of viral infection in the development of Hashimoto's thyroiditis. However, not only pathogenic microorganisms but also non-pathogenic commensal microorganisms induce proinflammatory or regulatory immune responses within the host. In accordance, series of studies indicate a critical role of intestinal commensal microbiota in the development of autoimmune diseases including inflammatory bowel diseases, type 1 diabetes, rheumatoid arthritis, and multiple sclerosis...
November 2012: Discovery Medicine
https://www.readbyqxmd.com/read/23166414/association-of-toll-like-receptor-2-polymorphisms-with-papillary-thyroid-cancer-and-clinicopathologic-features-in-a-korean-population
#18
Mi Kyeong Kim, Sung Wook Park, Su Kang Kim, Hae Jeong Park, Young Gyu Eun, Kee Hwan Kwon, Jinju Kim
Toll-like receptors (TLRs) single nucleotide polymorphisms (SNPs) were analyzed in patients with papillary thyroid cancer (PTC; n = 133) and their clinicopathologic features and age-matched controls (n = 321) using direct sequencing. PTC patients were divided into subgroups according to size, number, location, extrathyroidal invasion and lymph node metastasis. The two SNPs of TLR2 gene were not associated with the development of PTC. In clinical analysis, two SNPs were associated with location of cancer (rs3804099, P = 0...
November 2012: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/23138464/tlr-10-polymorphism-and-papillary-thyroid-cancer-one-more-snp-to-consider
#19
EDITORIAL
Myriem Boufraqech, Catsim Fassassi, Electron Kebebew
No abstract text is available yet for this article.
February 2013: Endocrine
https://www.readbyqxmd.com/read/23124277/a-missense-polymorphism-rs11466653-met326thr-of-toll-like-receptor-10-tlr10-is-associated-with-tumor-size-of-papillary-thyroid-carcinoma-in-the-korean-population
#20
Su Kang Kim, Hae Jeong Park, Il Ki Hong, Joo-Ho Chung, Young Gyu Eun
Toll-like receptors (TLRs) are important components of innate immune response. The aim of this study was to investigate whether TLR gene cluster (TLR10-TLR1-TLR6) polymorphisms are associated with the etiology of papillary thyroid carcinoma (PTC) and its clinicopathologic characteristics. We recruited 94 PTC patients and 325 control subjects. Genotypes for each SNP were determined by direct sequencing. SNPStats and SPSS 18.0 were used to evaluate odds ratios (ORs), 95 % confidence intervals (CIs), and P values...
February 2013: Endocrine
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