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https://www.readbyqxmd.com/read/28931103/-current-situation-of-palliative-care-in-hungary-integrated-palliative-care-model-as-a-breakout-possibility
#1
Gábor Benyó, Miklós Lukács, Csilla Busa, László Mangel, Ágnes Csikós
Modern palliative-hospice care has gained space in Europe for more than 50 years. Since the initial empirical work of Cicely Saunders, palliative medicine has gained its place in evidence-based medicine in more and more countries. However, development, as in many other medical fields, is not uniform, there are big differences between countries in the world. There are also significant differences in development of care and the level of services within the European Union amongst Western and Eastern European countries...
September 20, 2017: Magyar Onkologia
https://www.readbyqxmd.com/read/28931054/reconstruction-of-reaching-movement-trajectories-using-electrocorticographic-signals-in-humans
#2
Omid Talakoub, Cesar Marquez-Chin, Milos R Popovic, Jessie Navarro, Erich T Fonoff, Clement Hamani, Willy Wong
In this study, we used electrocorticographic (ECoG) signals to extract the onset of arm movement as well as the velocity of the hand as a function of time. ECoG recordings were obtained from three individuals while they performed reaching tasks in the left, right and forward directions. The ECoG electrodes were placed over the motor cortex contralateral to the moving arm. Movement onset was detected from gamma activity with near perfect accuracy (> 98%), and a multiple linear regression model was used to predict the trajectory of the reaching task in three-dimensional space with an accuracy exceeding 85%...
2017: PloS One
https://www.readbyqxmd.com/read/28930986/low-pressure-vapor-assisted-solution-process-for-tunable-band-gap-pinhole-free-methylammonium-lead-halide-perovskite-films
#3
Carolin M Sutter-Fella, Yanbo Li, Nicola Cefarin, Aya Buckley, Quynh Phuong Ngo, Ali Javey, Ian D Sharp, Francesca M Toma
Organo-lead halide perovskites have recently attracted great interest for potential applications in thin-film photovoltaics and optoelectronics. Herein, we present a protocol for the fabrication of this material via the low-pressure vapor assisted solution process (LP-VASP) method, which yields ~19% power conversion efficiency in planar heterojunction perovskite solar cells. First, we report the synthesis of methylammonium iodide (CH3NH3I) and methylammonium bromide (CH3NH3Br) from methylamine and the corresponding halide acid (HI or HBr)...
September 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28930883/reproducibility-and-agreement-of-anterior-segment-parameter-measurements-obtained-using-the-casia2-and-spectralis-oct2-optical-coherence-tomography-devices
#4
Benjamin Y Xu, Derek D Mai, Rafaella C Penteado, Luke Sanders, Robert N Weinreb
PURPOSE: To assess the reproducibility and agreement of measurement values obtained from the Tomey CASIA2 and Heidelberg Spectralis OCT2 anterior segment optical coherence tomography (AS-OCT) devices. METHODS: Twenty eyes from ten subjects ranging from age 28 to 45 years with no history of eye conditions or intraocular surgery were included. Two scans were obtained with each device in a standardized dark-room environment after a period of dark adaptation. One AS-OCT image along the horizontal (temporal-nasal) meridian was analyzed per eye and per scan...
September 19, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28930812/role-of-radiation-therapy-in-the-multidisciplinary-management-of-uterine-carcinosarcoma
#5
Jillian R Gunther, Eva N Christensen, Pamela K Allen, Lois M Ramondetta, Anuja Jhingran, Nicole D Fleming, Elizabeth D Euscher, Karen H Lu, Patricia J Eifel, Ann H Klopp
OBJECTIVES: This study aimed to evaluate the impact of radiation therapy on outcomes for patients with uterine carcinosarcoma (UC). METHODS/MATERIALS: We retrospectively reviewed the records of 155 women with stage I (98), II (11), or III (46) UC who underwent total abdominal hysterectomy/bilateral salpingo-oophorectomy at our institution between 1990 and 2011. Survival rates were assessed using the Kaplan-Meier method and log-rank test. Univariate and multivariate Cox regression analyses were performed...
September 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28930675/dynamic-rearrangement-of-cell-states-detected-by-systematic-screening-of-sequential-anticancer-treatments
#6
Simon Koplev, James Longden, Jesper Ferkinghoff-Borg, Mathias Blicher Bjerregård, Thomas R Cox, Janine T Erler, Jesper T Pedersen, Franziska Voellmy, Morten O A Sommer, Rune Linding
Signaling networks are nonlinear and complex, involving a large ensemble of dynamic interaction states that fluctuate in space and time. However, therapeutic strategies, such as combination chemotherapy, rarely consider the timing of drug perturbations. If we are to advance drug discovery for complex diseases, it will be essential to develop methods capable of identifying dynamic cellular responses to clinically relevant perturbations. Here, we present a Bayesian dose-response framework and the screening of an oncological drug matrix, comprising 10,000 drug combinations in melanoma and pancreatic cancer cell lines, from which we predict sequentially effective drug combinations...
September 19, 2017: Cell Reports
https://www.readbyqxmd.com/read/28930639/50-years-of-research-in-ards-tidal-volume-selection-in-the-acute-respiratory-distress-syndrome
#7
Sarina K Sahetya, Jordi Mancebo, Roy G Brower
Mechanical ventilation (MV) is critical in the management of many patients with the acute respiratory distress syndrome (ARDS). However, MV can also cause ventilator-induced lung injury (VILI). The selection of an appropriate tidal volume is an essential part of a lung-protective MV strategy. Since the publication of a large randomized clinical trial demonstrating the benefit of lower tidal volumes, the use of tidal volumes of 6 mL/kg predicted body weight (PBW, based on sex and height) has been recommended in clinical practice guidelines...
September 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28930633/controlled-orientation-of-droplets-in-ellipsoid-filled-polymeric-emulsions-by-particle-parameters-and-flow-conditions
#8
Chaoying Mao, Yajiang Huang, Junlong Yang, Miqiu Kong, Yuan Wang, Qi Yang, Guangxian Li
The effect of particle parameters (aspect ratio, AR, and concentration) and flow conditions (gap spacing and shear rate) on droplet orientation deformation behavior in polystyrene (PS) particle-filled binary polymeric emulsions is investigated by using rheo-optical technique and confocal microscopy. Interesting vorticity orientation behavior is achieved by tailoring experimental conditions to gain rigid anisotropic droplets during slow confined shear flow. PS ellipsoids with high AR are found to reside both at the fluid interface in a monolayer side-on state and inside droplets, leading to the formation of rigid anisotropic droplets due to interfacial/bulk jamming effect at appropriate particle concentrations...
September 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28930571/role-of-pericytes-in-vascular-immunosurveillance
#9
Konstantin Stark, Kami Pekayvaz, Steffen Massberg
Pericytes build together with endothelial cells the microvascular vessel wall. They have been mainly implicated in angiogenesis and maintenance of the blood brain barrier, but there is accumulating evidence for an immunological function of pericytes. Occupying a strategic position between the blood stream and the interstitial space, pericytes are able to sense environmental cues from both sides in an organ-specific manner and serve as gatekeepers for innate immune cells. In addition, pericytes are able to interact with leukocytes mediated by adhesion molecules as well as chemokines and are involved from the development of leukocytes in the bone marrow to their migration to injured or infected areas in target tissues...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930433/high-resolution-graphene-films-for-electrochemical-sensing-via-inkjet-maskless-lithography
#10
John A Hondred, Loreen R Stromberg, Curtis L Mosher, Jonathan C Claussen
Solution-phase printing of nanomaterial-based graphene inks are rapidly gaining interest for fabrication of flexible electronics. However, scalable manufacturing techniques for high-resolution printed graphene circuits are still lacking. Here, we report a patterning technique [i.e., inkjet maskless lithography (IML)] to form high resolution, flexible, graphene films (line widths down to 20 µm) that significantly exceeds the current inkjet printing resolution of graphene (line widths ~ 60 µm). IML uses an inkjet printed polymer lacquer as a sacrificial pattern, viscous spin coated graphene, and a subsequent graphene lift-off to patterned films without the need for pre-fabricated stencils, templates or cleanroom technology (e...
September 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28930361/polyphilic-hydrogen-bonded-block-molecules-involving-semiperfluorinated-and-silylated-molecular-fragments
#11
Laura Vogel, Dietmar Janietz, Marko Prehm, Carsten Tschierske
2,4-Diamino-6-phenyl-1,3,5-triazines grafted with one or two semiperfluorinated chains at the phenyl substituent have been investigated in binary mixtures with one-chain and two-chain oligo(dimethylsiloxy) terminated 4-alkoxy- and 3,4-dialkoxybenzoic acids. Equimolar mixtures of the triazines with the complementary acids form discrete double hydrogen-bonded heterodimers with an elongated central core. Mesomorphic properties are observed only if at least two terminal fluoroalkyl chains are attached to the triazine entity...
September 20, 2017: Soft Matter
https://www.readbyqxmd.com/read/28930176/high-sensitivity-encoder-like-micro-area-changed-capacitive-transducer-for-a-nano-g-micro-accelerometer
#12
Wenjie Wu, Panpan Zheng, Jinquan Liu, Zhu Li, Ji Fan, Huafeng Liu, Liangcheng Tu
Encoder-like micro area-changed capacitive transducers are advantageous in terms of their better linearity and larger dynamic range compared to gap-changed capacitive transducers. Such transducers have been widely applied in rectilinear and rotational position sensors, lab-on-a-chip applications and bio-sensors. However, a complete model accounting for both the parasitic capacitance and fringe effect in area-changed capacitive transducers has not yet been developed. This paper presents a complete model for this type of transducer applied to a high-resolution micro accelerometer that was verified by both simulations and experiments...
September 20, 2017: Sensors
https://www.readbyqxmd.com/read/28930162/lean-body-mass-harbors-sensing-mechanisms-that-allow-safeguarding-of-methionine-homeostasis
#13
REVIEW
Yves Ingenbleek
Protein-depleted states generate allosteric inhibition of liver cystathionine β-synthase (CBS), which governs the first enzymatic step of the transsulfuration cascade, resulting in upstream accretion of homocysteine (Hcy) in body fluids. A similar Hcy increase may arise from normal hepatocytes undergoing experimentally-induced impairment of betaine-homocysteine methyltransferase (BHTM) activity or from components of lean body mass (LBM) submitted to any inflammatory disorder. LBM comprises a composite agglomeration of extrarenal tissues characterized by naturally occurring BHTM inactivity...
September 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28929966/-a-case-with-scalp-pruritus-caused-by-dermanysus-gallinae-order-mesostigmata
#14
Mustafa Şengül, Nida Kaçar, Mehmet Karaca, Sedef Zeliha Öner, Çağrı Ergin
Dermanyssus gallinae is one of the important hematophagous ectoparasite species of poultry like chicken, pigeon and wild bird species. These ectoparasites in the form of nymphs or adults who can not find their hosts are also seen in mammals and even in humans. For this reason, they are considered as important for public health. The ectoparasite causes a clinical condition named gamasoidosis among pet owners and people who live or work close to animal shelters, barns and chicken farms. Pruritus dermatitis is also caused by D...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28929756/fragment-based-discovery-and-optimization-of-enzyme-inhibitors-by-docking-of-commercial-chemical-space
#15
Axel Rudling, Robert Gustafsson, Ingrid Almlöf, Evert J Homan, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark, Jens Carlsson
Fragment-based lead discovery has emerged as a leading drug development strategy for novel therapeutic targets. Despite that fragment-based drug discovery benefits immensely from access to atomic-resolution information, structure-based virtual screening has rarely been used to drive fragment discovery and optimization. Here, molecular docking of 0.3 million fragments to a crystal structure of cancer target MTH1 was performed. Twenty-two predicted fragment ligands, for which analogs could be acquired commercially, were experimentally evaluated...
September 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28929755/nanowires-of-geobacter-sulfurreducens-require-redox-cofactors-to-reduce-metals-in-pore-spaces-too-small-for-cell-passage
#16
Kyle Michelson, Robert A Sanford, Albert J Valocchi, Charles J Werth
Members of the Geobacteraceae family are ubiquitous metal reducers that utilize conductive 'nanowires' to reduce Mn(IV) and Fe(III) oxides in anaerobic sediments. However, it is not currently known if and to what extent the Mn(IV) and Fe(III) oxides in soil grains and low permeability sediments that are sequestered in pore spaces too small for cell passage can be reduced by long-range extracellular electron transport via Geobacter nanowires, and what mechanisms control this reduction. We developed a microfluidic reactor that physically separates Geobacter sulfurreducens from the Mn(IV) mineral birnessite by a 1...
September 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28929611/microfluidic-generation-of-bioinspired-spindle-knotted-graphene-microfibers-for-oil-absorption
#17
Ziqian Wu, Jie Wang, Ze Zhao, Yunru Yu, Luoran Shang, Yuanjin Zhao
Graphene materials have a demonstrated value in water treatment. Efforts to promote these materials are focused on the generation of functional graphene adsorbents for effectively removing contaminants from water. Here, inspired by the conformation of spider silks, we present a novel graphene microfiber material with spindle-knotted microstructures by using a microfluidic emulsification and spinning collaborative technology. The size and spacing of the spindle-knots were highly controllable by adjusting the flow rates of microfluidics during the generation process of the microfibers...
September 20, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28929509/task-dependent-output-of-human-parasternal-intercostal-motor-units-across-spinal-levels
#18
Anna L Hudson, Simon C Gandevia, Jane E Butler
During inspiration, there is differential activity in the human parasternal intercostal muscles across interspaces. We studied if the earlier recruitment of motor units in the rostral interspaces, compared to more caudal spaces, during inspiration is preserved for the non-respiratory task of ipsilateral trunk rotation. Single motor unit activity (SMU) was recorded from the first, second and fourth parasternal interspaces on the right side in five participants in two tasks: resting breathing and 'isometric' axial rotation of the trunk during apnoea...
September 20, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28929312/the-effect-of-hand-position-on-perceived-finger-orientation-in-left-and-right-handers
#19
Lindsey E Fraser, Laurence R Harris
In the absence of visual feedback, the perceived orientation of the fingers is systematically biased. In right-handers these biases are asymmetrical between the left and right hands in the horizontal plane and may reflect common functional postures for the two hands. Here we compared finger orientation perception in right- and left-handed participants for both hands, across various hand positions in the horizontal plane. Participants rotated a white line on a screen optically superimposed over their hand to indicate the perceived position of the finger that was rotated to one of seven orientations with the hand either aligned with the body midline, aligned with the shoulder, or displaced by twice the shoulder-to-midline distance from the midline...
September 19, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28929304/embryonic-body-culturing-in-an-all-glass-microfluidic-device-with-laser-processed-4%C3%A2-%C3%AE-m-thick-ultra-thin-glass-sheet-filter
#20
Y Yalikun, N Tanaka, Y Hosokawa, T Iino, Y Tanaka
In this paper, we report the development and demonstration of a method to fabricate an all-glass microfluidic cell culturing device without circulation flow. On-chip microfluidic cell culturing is an indispensable technique for cellular replacement therapies and experimental cell biology. Polydimethylsiloxane (PDMS) have become a popular material for fabricating microfluidic cell culture devices because it is a transparent, biocompatible, deformable, easy-to-mold, and gas-permeable. However, PDMS is also a chemically and physically unstable material...
September 19, 2017: Biomedical Microdevices
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