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https://www.readbyqxmd.com/read/28735383/brucellosis-causes-alteration-in-trace-elements-and-oxidative-stress-factors
#1
Naser Zanganeh, Ehsan Siahpoushi, Nejat Kheiripour, Sima Kazemi, Mohammad Taghi Goodarzi, Mohammad Yousef Alikhani
Brucellosis is regarded as one of the most common diseases among humans and livestock. In the present study, we aimed to assess the effect of this disease on the level of various cations including copper (Cu), manganese (Mn), zinc (Zn), and magnesium (Mg) as well as oxidative stress status in the serum of people suffering from brucellosis. The present case-study was carried out on 40 patients with brucellosis (case) and 20 healthy people (control). Blood specimens were taken from all the people and the level of essential trace elements and oxidative stress status were measured...
July 22, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28734785/impact-of-magnetic-stirring-on-stainless-steel-integrity-effect-on-biopharmaceutical-processing
#2
Christopher Thompson, Kelly Wilson, Yoen Joo Kim, Min Xie, William K Wang, Michaela Wendeler
Stainless steel containers are widely used in the pharmaceutical and biopharmaceutical industry for the storage of buffers, process intermediates, and purified drug substance. They are generally held to be corrosion resistant, biocompatible, and non-reactive, although it is well established that trace amounts of metal ions can leach from stainless steel equipment into biopharmaceutical products. We report here that the use of stainless steel containers in conjunction with magnetic stirring bars leads to significantly aggravated metal contamination, consisting both of metal particles and significantly elevated metal ions in solution, the degree of which is several orders of magnitude higher than described for static conditions...
July 19, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28733937/sequential-extraction-as-novel-approach-to-compare-12-medicinal-plants-from-kenya-regarding-their-potential-to-release-chromium-manganese-copper-and-zinc
#3
R Mogwasi, S Zor, D K Kariuki, M Z Getenga, V Nischwitz
This study is focusing on a novel approach to screen a large number of medicinal plants from Kenya regarding their contents and availability of selected metals potentially relevant for treatment of diabetes patients. For this purpose, total levels of zinc, chromium, manganese, and copper were determined by flame atomic absorption spectrometry and inductively coupled plasma mass spectrometry as well as BCR sequential extraction to fractionate the elemental species in anti-diabetic medicinal plants collected from five natural locations in two sub counties in Nyamira County, Kenya...
July 21, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28733784/environmental-impact-of-coal-mining-and-coal-seam-gas-production-on-surface-water-quality-in-the-sydney-basin-australia
#4
A Ali, V Strezov, P Davies, I Wright
The extraction of coal and coal seam gas (CSG) will generate produced water that, if not adequately treated, will pollute surface and groundwater systems. In Australia, the discharge of produced water from coal mining and related activities is regulated by the state environment agency through a pollution licence. This licence sets the discharge limits for a range of analytes to protect the environment into which the produced water is discharged. This study reports on the impact of produced water from coal mine activities located within or discharging into high conservation environments, such as National Parks, in the outer region of Sydney, Australia...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28731769/first-principles-prediction-of-spin-polarized-multiple-dirac-rings-in-manganese-fluoride
#5
Yalong Jiao, Fengxian Ma, Chunmei Zhang, John Bell, Stefano Sanvito, Aijun Du
Spin-polarized materials with Dirac features have sparked great scientific interest due to their potential applications in spintronics. But such a type of structure is very rare and none has been fabricated. Here, we investigate the already experimentally synthesized manganese fluoride (MnF_{3}) as a novel spin-polarized Dirac material by using first-principles calculations. MnF_{3} exhibits multiple Dirac cones in one spin orientation, while it behaves like a large gap semiconductor in the other spin channel...
July 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28731687/intramolecular-c-h-and-c-f-bond-oxygenation-by-site-differentiated-tetranuclear-manganese-models-of-the-oec
#6
Kurtis M Carsch, Graham de Ruiter, Theodor Agapie
The dangler manganese center in the oxygen-evolving complex (OEC) of photosystem II plays an important role in the oxidation of water to dioxygen. Inspired by the structure of the OEC, we synthesized a series of site-differentiated tetra-manganese clusters [LMn3(PhPz)3OMn][OTf]x (2: x = 2; 3: x = 1) that features an apical manganese ion-distinct from the others-that is appended to a trinuclear manganese core through an μ4-oxygen atom bridge. This cluster design was targeted to facilitate studies of high-valent Mn-oxo formation, which is a proposed step in the mechanism for water oxidation by the OEC...
July 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28731108/manganese-mediated-synthesis-of-an-nhc-core-non-symmetric-pincer-ligand-and-evaluation-of-its-coordination-properties
#7
Dmitry A Valyaev, Jérémy Willot, Loïc P Mangin, Davit Zargarian, Noël Lugan
The alkylation of N-(2-pyridyl)imidazole by the Mn(I) methylene-phosphonium complex [Cp(CO)2Mn(η(2)-P,C-Ph2P[double bond, length as m-dash]C(H)Ph)]BF4 offers a straightforward route to a tridentate pro-ligand featuring an NHC core and phosphine/pyridine arms. The ability of this PĈN ligand to coordinate in a pincer mode was recognized in Rh(I), Rh(III), and Ni(II) complexes.
July 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28730716/manganese-i-catalyzed-enantioselective-hydrogenation-of-ketones-using-a-defined-chiral-pnp-pincer-ligand
#8
Marcel Garbe, Kathrin Junge, Svenja Walker, Zhihong Wei, Haijun Jiao, Anke Spannenberg, Stephan Bachmann, Michelangelo Scalone, Matthias Beller
A new chiral manganese PNP pincer complex is described. Asymmetric hydrogenation of several prochiral ketones with molecular hydrogen in the presence of this complex proceeds under mild conditions (40 °C, 4 h, 30 bar H₂). Besides high catalytic activity for aromatic substrates, aliphatic ketones are hydrogenated with remarkable selectivities (er up to 92:8). DFT calculations support an outer sphere hydrogenation mechanism as well as the experimentally determined stereochemistry.
July 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28730426/phytaspase-loaded-mn-doped-zns-quantum-dots-when-embedded-into-chitosan-nanoparticles-leads-to-improved-chemotherapy-of-hela-cells-using-in-cisplatin
#9
Sharmila Narayanan, Deepanjalee Dutta, Neha Arora, Lingaraj Sahoo, Siddhartha Sankar Ghosh
OBJECTIVES: To investigate the potential of recombinant phytaspase loaded manganese (Mn) doped zinc sulphide (ZnS) quantum dots embedded chitosan nanoparticles for augmenting cisplatin induced chemotherapy of HeLa cells. RESULTS: The recombinant phytaspase was cloned into bacterial expression vector PGEX-4T-2. The expressed and purified recombinant plant phytaspase protein from Escherichia coli BL21 was immobilized onto the cationic nanocomposite. Confocal microscopy elucidated the delivery of these luminescent nanocomposites inside cervical cancer HeLa cells...
July 20, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28730349/manganese-mediated-decrease-in-levels-of-c-ret-and-tyrosine-hydroxylase-expression-in-vitro
#10
Mayuko Y Kumasaka, Ichiro Yajima, Nobutaka Ohgami, Hiromasa Ninomiya, Machiko Iida, Xiang Li, Reina Oshino, Hiroko Tanihata, Masafumi Yoshinaga, Masashi Kato
Previous studies showed that overexposure to manganese causes parkinsonism, a disorder of dopaminergic neurons. Previous studies also showed that activity of c-RET kinase controls dopamine production through regulation of tyrosine hydroxylase (TH) expression, suggesting the involvement of c-RET in the development of parkinsonism. To our knowledge, however, there is no report showing a correlation between manganese-mediated parkinsonism and c-RET. In this study, we examined the effect of manganese on the expression and/or activation levels of c-RET and TH in human TH-expressing cells (TGW cells)...
July 20, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28729937/manganese-enhanced-magnetic-resonance-imaging-combined-with-electrophysiology-in-the-evaluation-of-visual-pathway-in-experimental-rat-models-with-monocular-blindness
#11
Zuohua Tang, Jie Wang, Zebin Xiao, Xinghuai Sun, Xiaoyuan Feng, Weijun Tang, Qian Chen, Lingjie Wu, Rong Wang, Yufeng Zhong, Wentao Wang, Jianfeng Luo
PURPOSE: Our study aimed to explore the feasibility of manganese-enhanced magnetic resonance imaging (MEMRI) combined with visual evoked potentials (VEP) and auditory evoked visual cortex responses (AVR) in evaluating for the establishment of visual/auditory compensatory pathways after monocular blindness. MATERIALS AND METHODS: A total of 14 healthy neonatal male Sprague-Dawley rats were randomly divided into two groups (n = 7 for Groups A and B). Right optic nerve (ON) transection was performed on the 7 rats of Group A to obtain a monocularly blind model, and the 7 rats of Group B were chosen as the control group...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28728787/prenatal-co-exposure-to-manganese-and-depression-and-24-months-neurodevelopment
#12
Teresa Verenice Muñoz Rocha, Marcela Tamayo Y Ortiz, Martín Romero, Ivan Pantic, Lourdes Schnaas, David Bellinger, Birgit Claus Henn, Rosalind Wright, Robert O Wright, Mara Téllez-Rojo
BACKGROUND: Normal prenatal neurodevelopment follows stages that are potentially influenced by both chemical and psychosocial environments. Exposure to elevated manganese during this critically vulnerable period has been found to be neurotoxic. Independently, maternal prenatal depression has been associated with subsequent neurodevelopmental decrements in children. The association between child neurodevelopment and prenatal co-exposure to manganese and maternal depression has not been sufficiently studied...
July 17, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28728562/low-oxygen-tension-increases-mitochondrial-membrane-potential-and-enhances-expression-of-antioxidant-genes-and-implantation-protein-of-mouse-blastocyst-cultured-in-vitro
#13
Yun-Yi Ma, Huei-Wen Chen, Chii-Ruey Tzeng
BACKGROUND: In human IVF, embryos cultured with a lower O2 tension (5%) can give rise to higher success rates when compared with normoxic conditions (20%). However, the mechanisms behind the beneficial effects of reduced oxygen tension in embryogenesis remain unclear. The aim of this study was to evaluate the expression of oxygen related and antioxidant genes and mitochondrial function in mouse embryo cultured under hypoxic and normoxic conditions, to investigate the beneficial effect of low oxygen tension in preimplantation embryogenesis...
July 20, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28726856/manganese-catalyzed-synthesis-of-monofluoroalkenes-via-c-h-activation-and-c-f-cleavage
#14
Sai-Hu Cai, Lu Ye, Ding-Xing Wang, Yi-Qiu Wang, Lin-Jie Lai, Chuan Zhu, Chao Feng, Teck-Peng Loh
The manganese-catalyzed α-fluoroalkenylation of arenes via C-H activation and C-F cleavage has been described. This protocol provides a very useful method for the synthesis of monofluoroalkenes with predominant unconventional E-isomer selectivity which complements the existing strategies for the access to these molecular architectures. In addition, the selectivity of β-defluorination in the catalytic cycle not only determines the configurations of the products but also obviates the use of external oxidants, providing a good example in the exploitation of manganese-catalyzed redox-neutral C-H transformations...
July 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28726316/deprotonation-states-of-the-two-active-site-water-molecules-regulate-the-binding-of-protein-phosphatase-5-with-its-substrate-a-molecular-dynamics-study
#15
Lingyun Wang, Feng Yan
Protein phosphatase 5 (PP5), mainly localized in human brain, can dephosphorylate tau protein whose high level of phosphorylation is related to Alzheimer's disease. Similar to other protein phosphatases, PP5 has a conserved motif in the catalytic domain that contains two binding sites for manganese (Mn(2+) ) ions. Structural data indicate that two active site water molecules, one bridging the two Mn(2+) ions and the other terminally coordinated with one of the Mn(2+) ions (Mn1), are involved in catalysis. Recently, a density functional theory study revealed that the two water molecules can be both deprotonated to keep a neutral active site for catalysis...
July 20, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28724899/carrier-dynamics-of-mn-induced-states-in-gan-thin-films
#16
Yu-Ting Chen, Chi-Yuan Yang, Po-Cheng Chen, Jinn-Kong Sheu, Kung-Hsuan Lin
GaN-based materials are widely used for light emission devices, but the intrinsic property of wide bandgap makes it improper for photovoltaic applications. Recently, manganese was doped into GaN for absorption of visible light, and the conversion efficiency of GaN-based solar cells has been greatly improved. We conducted transient optical measurements to study the carrier dynamics of Mn-doped GaN. The lifetime of carriers in the Mn-related intermediate bands (at 1.5 eV above the valence band edge) is around 1...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28722486/neurotoxic-effects-of-subchronic-intratracheal-mn-nanoparticle-exposure-alone-and-in-combination-with-other-welding-fume-metals-in-rats
#17
Zsuzsanna Máté, Edina Horváth, András Papp, Krisztina Kovács, Etelka Tombácz, Dániel Nesztor, Tamás Szabó, Andrea Szabó, Edit Paulik
Manganese (Mn) is a toxic heavy metal exposing workers in various occupational settings and causing, among others, nervous system damage. Metal fumes of welding, a typical source of Mn exposure, contain a complex mixture of metal oxides partly in nanoparticle form. As toxic effects of complex substances cannot be sufficiently understood by examining its components separately, general toxicity and functional neurotoxicity of a main pathogenic welding fume metal, Mn, was examined alone and combined with iron (Fe) and chromium (Cr), also frequently found in fumes...
July 19, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28722450/two-new-sandwich-type-manganese-mn5-substituted-polyoxotungstates-syntheses-crystal-structures-electrochemistry-and-magnetic-properties
#18
Rakesh Gupta, Imran Khan, Firasat Hussain, A Martin Bossoh, Israël M Mbomekallé, Pedro de Oliveira, Masahiro Sadakane, Chisato Kato, Katsuya Ichihashi, Katsuya Inoue, Sadafumi Nishihara
Herein we report two pentanuclear Mn(II)-substituted sandwich-type polyoxotungstate complexes, [{Mn(bpy)}2Na(H2O)2(MnCl)2{Mn(H2O)}(AsW9O33)2](9-) and [{Mn(bpy)}2Na(H2O)2(MnCl){Mn(H2O)}2(SbW9O33)2](8-) (bpy = 2,2'-bipyridine), whose structures have been obtained by single-crystal X-ray diffraction (SCXRD), complemented by results obtained from elemental analysis, electrospray ionization mass spectrometry, Fourier transform infrared spectroscopy, and thermogravimetric analysis. They consist of two [B-α-XW9O33](9-) subunits sandwiching a cyclic assembly of the hexagonal [{Mn(bpy)}2Na(H2O)2(MnCl)2{Mn(H2O)}](9+) and [{Mn(bpy)}2Na(H2O)2(MnCl){Mn(H2O)}2](10+) moieties, respectively, and represent the first pentanuclear Mn(II)-substituted sandwich-type polyoxometalates (POMs)...
July 19, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28722330/tunable-biogenic-manganese-oxides
#19
Alexandr Nikolaevich Simonov, Rosalie K Hocking, Lizhi Tao, Thomas Gengenbach, Timothy Williams, Xi-Ya Fang, Hannah J King, Shannon A Bonke, Dijon A Hoogeveen, Christine A Romano, Bradley M Tebo, Lisandra L Martin, William H Casey, Leone Spiccia
Influence of the conditions for aerobic oxidation of Mn2+(aq) catalysed by the MnxEFG protein complex on the morphology, structure and reactivity of the resulting biogenic manganese oxides (MnOx) is explored. Physical characterisation of MnOx includes scanning and transmission electron microscopies, X-ray photoelectron and K-edge Mn, Fe X-ray absorption spectroscopies. This characterisation reveals that the MnOx materials share the structural features of birnessite, yet differ in the degree of structural disorder...
July 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28720645/influences-of-manganese-on-pubertal-development
#20
W Les Dees, Jill K Hiney, Vinod K Srivastava
The onset of puberty is the result of complex neuroendocrine interactions within hypothalamic region of the brain, as well as from genetic and environmental influences. These interactions ultimately result in the increased synthesis and release of luteinizing hormone- releasing hormone (LHRH). Manganese (Mn) is an essential environmental element known for years to be involved in numerous mammalian physiological processes, including growth and reproductive function. Studies in recent years have shown the ability of Mn to cross the blood-brain barrier and act within the hypothalamus to influence the timing of puberty...
July 18, 2017: Journal of Endocrinology
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