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https://www.readbyqxmd.com/read/28929146/immobilization-of-alkynyl-functionalized-manganese-phthalocyanine-via-click-electrochemistry-for-electrocatalytic-oxygen-evolution-reaction
#1
B Öztaş, D Akyüz, A Koca
Peripherally and non-peripherally terminal alkynyl substituted manganese phthalocyanines (MnPc) were synthesized and characterized and then used as functional materials in modified electrodes. MnPcs were substituted with alkynyl groups, which are reactive moieties in click electrochemistry (CEC) reactions. Mn(iii) cations were incorporated into the cavity of the Pc ring in order to increase the redox activity of the complexes. Electrochemical characterizations of the complexes were determined by voltammetric and in situ spectroelectrochemical measurements in order to determine their possible technological applications...
September 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28928443/affected-energy-metabolism-under-manganese-stress-governs-cellular-toxicity
#2
Gursharan Kaur, Vineet Kumar, Amit Arora, Ajay Tomar, Ashish, Runa Sur, Dipak Dutta
Excessive manganese exposure is toxic, but a comprehensive biochemical picture of this assault is poorly understood. Whether oxidative stress or reduced energy metabolism under manganese exposure causes toxicity is still a debate. To address this, we chose Δmnt P Escherichia coli, a highly manganese-sensitive strain, in this study. Combining microarray, proteomics, and biochemical analyses, we show that the chronic manganese exposure rewires diverse regulatory and metabolic pathways. Manganese stress affects protein and other macromolecular stability, and envelope biogenesis...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928081/microrna-140-5p-attenuated-oxidative-stress-in-cisplatin-induced-acute-kidney-injury-by-activating-nrf2-are-pathway-through-a-keap1-independent-mechanism
#3
Weitang Liao, Zongjie Fu, Yanfang Zou, Dan Wen, Hongkun Ma, Fangfang Zhou, Yongxi Chen, Mingjun Zhang, Wen Zhang
Oxidative stress was predominantly involved in the pathogenesis of acute kidney injury (AKI). Recent studies had reported the protective role of specific microRNAs (miRNAs) against oxidative stress. Hence, we investigated the levels of miR140-5p and its functional role in the pathogenesis of Cisplatin induced AKI. A mice Cisplatin induced-AKI model was established. We found that miR-140-5p expression was markedly increased in mice kidney. Bioinformatics analysis revealed nuclear factor erythroid 2-related factor (Nrf2) was a potential target of miR-140-5p, We demonstrated that miR-140-5p did not affect Kelch-like ECH-associated protein 1 (Keap1) levels but directly targeted the 3'-UTR of Nrf2 mRNA and played a positive role in the regulation of Nrf2 expression which was comfirmed by luciferase activity assay and western blot...
September 16, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28926949/influence-of-freeze-drying-and-oven-drying-post-blanching-on-the-nutrient-composition-of-the-edible-insect-ruspolia-differens
#4
Forkwa Tengweh Fombong, Mik Van Der Borght, Jozef Vanden Broeck
The longhorn grasshopper, Ruspolia differens (Serville), plays an important role as a food source across Sub-Saharan Africa, where it is consumed as a delicacy in both rural and urban areas. The effect of two drying methods (freeze-drying and oven-drying), employed after blanching, on the proximate, fatty acid and mineral composition of the two most common morphs was determined. Ruspolia differens grasshoppers were harvested in Uganda and Kenya from wild swarms during the rainy periods of November-December 2016...
September 16, 2017: Insects
https://www.readbyqxmd.com/read/28926938/integrin-activation-contributes-to-lower-cisplatin-sensitivity-in-mv3-melanoma-cells-by-inducing-the-wnt-signalling-pathway
#5
Maria B R Piva, Bastian Jakubzig, Gerd Bendas
BACKGROUND: integrins have been associated with the development of chemotherapy resistant tumour cells, mostly those of hematopoietic origin, by mediating the binding to the extracellular matrix. The relevance for solid tumour cells and the underlying mechanisms remain elusive. METHODS: using MTT assays, we detected the loss in cisplatin sensitivity of human MV3 melanoma cells upon integrin activation. Underlying cellular pathways were evaluated by flow cytometry...
September 16, 2017: Cancers
https://www.readbyqxmd.com/read/28926757/mn-ii-based-t1-and-t2-potential-mri-contrast-agent-appended-with-tryptamine-recognition-moiety-for-a%C3%AE-plaques
#6
Neeraj Rastogi, Nidhi Tyagi, Ovender Singh, B S Hemanth Kumar, Udai P Singh, Kaushik Ghosh, Raja Roy
We report the synthesis and characterization of manganese(II) complexes having pentadentate ligands L1 (2,6-bis(1-(2-phenyl-2-(pyridin-2-yl)hydrazono)ethyl)pyridine), L2 (methyl 2,6-bis((E)-1-(2-phenyl-2-(pyridin-2yl)hydrazono)ethyl)isonicotinate), L3 (N-(2-(1H-indol-3-yl)ethyl)-2,6-bis((E)-1-(2-phenyl-2-(pyridin2yl)hydrazono)ethyl)isonicotiamide) and their application as dual contrast agents for simultaneous T1 and T2 weighted magnetic resonance imaging. Single crystal analysis of all the complexes [Mn(II)L1, Mn(II)L2 and Mn(II)L3] confirm the formation of novel seven-coordinate manganese complexes with an inner sphere water and perchlorate ion...
September 5, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28925701/interaction-of-co2-with-atomic-manganese-in-the-presence-of-an-excess-negative-charge-probed-by-infrared-spectroscopy-of-mn-co2-n-clusters
#7
Michael Charles Thompson, Jacob Ramsay, J Mathias Weber
We report infrared photodissociation spectra of manganese-CO2 cluster anions,[Mn(CO2)n](-) (n = 2 - 10) to probe structural motifs characterizing the interaction between Mn and CO2 in the presence of an excess electron. We interpret the experimental spectra through comparison with infrared spectra predicted from density functional theory calculations. The cluster anions consist of core ions combining a Mn atom with a variety of ligands, solvated by additional CO2 molecules. Structural motifs of ligands evolve with increasing cluster size from simple monodentate and bidentate CO2 ligands to oxalate ligands and combinations of these structural themes...
September 19, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28925004/size-dependent-reactivity-of-nano-sized-neutral-manganese-oxide-clusters-toward-ethylene
#8
Jiao-Jiao Chen, Ting Zhang, Mei-Qi Zhang, Qing-Yu Liu, Xiao-Na Li, Sheng-Gui He
Neutral manganese oxide clusters Mn2NO3N+x (N = 2-22; x = -1, 0, 1) with dimensions up to a nanosize were prepared by laser ablation and reacted with C2H4 in a fast flow reactor. The size-dependent reactivity of C2H4 adsorption on these clusters was experimentally identified and the adsorption reactivity decreases generally with the increase of cluster size. Density functional theory calculations were performed to study the geometrical and electronic structures of Mn2NO3N (N = 1-6) clusters. The calculated results indicated that the coordination number and the charge distribution of the metal centers are responsible for the experimentally observed size-dependent reactivity...
September 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28924626/peppermint-trees-shift-their-phosphorus-acquisition-strategy-along-a-strong-gradient-of-plant-available-phosphorus-by-increasing-their-transpiration-at-very-low-phosphorus-availability
#9
Gang Huang, Patrick E Hayes, Megan H Ryan, Jiayin Pang, Hans Lambers
Some plant species use different strategies to acquire phosphorus (P) dependent on environmental conditions, but studies investigating the relative significance of P-acquisition strategies with changing P availability are rare. We combined a natural P availability gradient and a glasshouse study with 10 levels of P supplies to investigate the roles of rhizosphere carboxylates and transpiration-driven mass flow in P acquisition by Agonis flexuosa. Leaf P concentrations of A. flexuosa decreased and leaf manganese (Mn) concentrations increased with decreasing soil P concentration along a dune chronosequence...
September 18, 2017: Oecologia
https://www.readbyqxmd.com/read/28923736/atomic-layered-mn-clusters-deposited-on-palygorskite-as-powerful-adsorbent-for-recovering-valuable-rees-from-wastewater-with-superior-regeneration-stability
#10
Xujian Li, Xing Zhang, Heng Yang, Qi Zhou
The control of dispersity and size of metal particles deposited on substrate surface are always the major challenges for fabricating the efficient and stable metallic nanoparticles-decorated composite. Herein, we proposed a simple liquid-phase atomic layer deposition (L-ALD) method to obtain an atomic-layered MnO2 nanoparticles loaded palygorskite nanorod (MnO2@Pal), involving two-step procedures comprised of the solid-liquid interfacial reaction between organic manganese precursor and surface hydroxyl groups of palygorskite, and then a calcination treatment to activate surface Mn, which is used as a powerful adsorbent for recovery of REE ions from wastewater...
September 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28922747/allelic-variation-of-ntnramp5-associated-with-cultivar-variation-in-cadmium-accumulation-in-tobacco
#11
Zhong Tang, Hailin Cai, Jie Li, Yanling Lv, Wenwen Zhang, Fang-Jie Zhao
Tobacco (Nicotiana tabacum) is a cadmium (Cd) accumulator, and smoking is a major source of Cd exposure. In the present study, we identified two tobacco cultivars with contrasting phenotypes of Cd and manganese (Mn) accumulation in both hydroponic and soil pot experiments. Physiological experiments showed that the two cultivars differed in Cd uptake, but not in Cd translocation from roots to shoots. A homolog of OsNramp5 (natural resistance-associated macrophage protein 5), NtNramp5, was isolated from both cultivars...
September 1, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28922532/redox-modulatory-mn3o4-nanozyme-with-multi-enzyme-activity-provides-efficient-cytoprotection-to-human-cells-in-parkinson-s-disease-model
#12
Govindasamy Mugesh, Namrata Singh, Mohammed Azharuddin Savanur, Shubhi Srivastava, Patrick D'Silva
Nanomaterials with enzyme-like activities (nanozymes) attracts significant interest due to their therapeutic potential for the treatment of various diseases. Herein, we report that a Mn3O4 nanozyme functionally mimic three major antioxidant enzymes, i.e. superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the multienzyme activity is size as well as morphology-dependent. The redox modulatory effect of Mn3O4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)-like cellular model, indicating that manganese-based nanomaterials having multi-enzyme activity can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS-mediated neurological disorders...
September 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28921983/the-first-state-in-the-catalytic-cycle-of-the-water-oxidizing-enzyme-identification-of-a-water-derived-%C3%AE-hydroxo-bridge
#13
Thomas Lohmiller, Vera Krewald, Arezki Sedoud, A William Rutherford, Frank Neese, Wolfgang Lubitz, Dimitrios A Pantazis, Nicholas Cox
Nature's water splitting catalyst, an oxygen-bridged tetra-manganese calcium (Mn4O5Ca) complex, sequentially activates two substrate water molecules generating molecular O2. Its reaction cycle is composed of five intermediate (Si) states, where the index i indicates the number of oxidizing equivalents stored by the cofactor. After formation of the S4 state, the product dioxygen is released and the cofactor returns to its lowest oxidation state, S0. Membrane-inlet mass spectrometry measurements suggest that at least one substrate is bound throughout the catalytic cycle, as the rate of (18)O-labeled water incorporation into the product O2 is slow, on a millisecond to second timescale depending on the S state...
September 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28920984/tailoring-the-morphology-followed-by-the-electrochemical-performance-of-nimn-ldh-nanosheet-arrays-through-controlled-co-doping-for-high-energy-and-power-asymmetric-supercapacitors
#14
Saurabh Singh, Nanasaheb M Shinde, Qi Xun Xia, Chandu V V M Gopi, Je Moon Yun, Rajaram S Mane, Kwang Ho Kim
Herein, we tailor the surface morphology of nickel-manganese-layered double hydroxide (NiMn-LDH) nanostructures on 3D nickel-foam via a step-wise cobalt (Co)-doping hydrothermal chemical process. At the 10% optimum level of Co-doping, we noticed a thriving tuned morphological pattern of NiMn-LDH nanostructures (NiCoMn-LDH (10%)) in terms of the porosity of the nanosheet (NS) arrays which not only improves the rate capability as well as cycling stability, but also demonstrates nearly two-fold specific capacitance enhancement compared to Co-free and other NiCoMn-LDH electrodes with a half-cell configuration in 3 M KOH, suggesting that Co-doping is indispensable for improving the electrochemical performance of NiMn-LDH electrodes...
September 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28920698/correlating-bridging-ligand-with-properties-of-ligand-templated-mn-ii-3x3-3-clusters-x-br-cl-h-meo
#15
Kevin J Anderton, David M Ermert, Pedro A Quintero, Mackenzie W Turvey, Majed S Fataftah, Khalil A Abboud, Mark W Meisel, Erik Čižmár, Leslie J Murray
Polynuclear manganese compounds have garnered interest as mimics and models of the water oxidizing complex (WOC) in photosystem II and as single molecule magnets. Molecular systems in which composition can be correlated to physical phenomena, such as magnetic exchange interactions, remain few primarily because of synthetic limitations. Here, we report the synthesis of a family of trimanganese(II) complexes of the type Mn3X3L (X = Cl(-), H(-), and MeO(-)) where L(3-) is a tris(β-diketiminate) cyclophane. The tri(chloride) complex (2) is structurally similar to the reported tri(bromide) complex (1) with the Mn3X3 core having a ladder-like arrangement of alternating M-X rungs, whereas the tri(μ-hydride) (3) and tri(μ-methoxide) (4) complexes contain planar hexagonal cores...
September 18, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28920672/assembling-hollow-cobalt-sulfide-nanocages-array-on-graphene-like-manganese-dioxide-nanosheets-for-superior-electrochemical-capacitors
#16
Hao Chen, Min Qiang Wang, Yanan Yu, Heng Liu, Shi-Yu Lu, Shu-Juan Bao, Maowen Xu
Metal-origanic frameworks (MOF)-derived hollow cobalt sulfides have attracted extensive attention due to their porous shell that provides rich redox reactions for energy storage. However, their ultra-dispersed structure and large size of MOFs precursors result in relatively low conductivity, stability, and low tap density .Therefore, the construction of an array of continuous hollow cages and tailor the inner cavity of MOF-derived materials is very effective for enhancing the electrochemical performance. Herein, we in situ assembled small Co-based zeolitic imidazolate framework (ZIF-67) on the both sides of negatively charged MnO2 nanosheets to fabricate a hierarchical sandwich-type composite with hollow cobalt sulfide nanocages/graphene-like MnO2...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28919711/protective-role-of-quercetin-against-manganese-induced-injury-in-the-liver-kidney-and-lung-and-hematological-parameters-in-acute-and-subchronic-rat-models
#17
Entaz Bahar, Geum-Hwa Lee, Kashi Raj Bhattarai, Hwa-Young Lee, Hyun-Kyoung Kim, Mallikarjun Handigund, Min-Kyung Choi, Sun-Young Han, Han-Jung Chae, Hyonok Yoon
Manganese (Mn) is an important mineral element required in trace amounts for development of the human body, while over- or chronic-exposure can cause serious organ toxicity. The current study was designed to evaluate the protective role of quercetin (Qct) against Mn-induced toxicity in the liver, kidney, lung, and hematological parameters in acute and subchronic rat models. Male Sprague Dawley rats were divided into control, Mn (100 mg/kg for acute model and 15 mg/kg for subchronic model), and Mn + Qct (25 and 50 mg/kg) groups in both acute and subchronic models...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28918510/acquired-hepatocerebral-degeneration-ahd-a-peculiar-neurological-impairment-in-advanced-chronic-liver-disease
#18
A Pigoni, F Iuculano, C Saetti, L Airaghi, L Burdick, S Spreafico, M Curioni, R Lombardi, L Valenti, A L Fracanzani, S Fargion
We discuss the case of a rare and often unrecognized neurologic syndrome, called Acquired Hepatocerebral Degeneration (AHD), observed in patients with advanced liver disease and portosystemic shunts. The clinical manifestations can be very heterogeneous and in our case included a combination of cerebellar and extrapyramidal signs, arisen in a period of few days. Brain Magnetic Resonance Imaging (MRI) showed, in T1-weighted images, diffuse bilateral hyper intensities in basal ganglia and biemispheric brain and cerebellar cortices, resembling paramagnetic deposits...
September 16, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28918289/effective-removal-of-trace-thallium-from-surface-water-by-nanosized-manganese-dioxide-enhanced-quartz-sand-filtration
#19
Xiaoliu Huangfu, Chengxue Ma, Jun Ma, Qiang He, Chun Yang, Jian Zhou, Jin Jiang, Yaan Wang
Thallium (Tl) has drawn wide concern due to its high toxicity even at extremely low concentrations, as well as its tendency for significant accumulation in the human body and other organisms. The need to develop effective strategies for trace Tl removal from drinking water is urgent. In this study, the removal of trace Tl (0.5 μg L(-1)) by conventional quartz sand filtration enhanced by nanosized manganese dioxide (nMnO2) has been investigated using typical surface water obtained from northeast China. The results indicate that nMnO2 enhanced quartz sand filtration could remove trace Tl(I) and Tl(III) efficiently through the adsorption of Tl onto nMnO2 added to a water matrix and onto nMnO2 attached on quartz sand surfaces...
September 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28917719/polymorphisms-in-manganese-transporters-show-developmental-stage-and-sex-specific-associations-with-manganese-concentrations-in-primary-teeth
#20
Karin Wahlberg, Manish Arora, Austen Curtin, Paul Curtin, Robert O Wright, Donald R Smith, Roberto G Lucchini, Karin Broberg, Christine Austin
BACKGROUND: Manganese (Mn) is an essential metal that can become neurotoxic at elevated levels with negative consequences on neurodevelopment. We have evaluated the influence of single nucleotide polymorphisms (SNPs) in Mn transporter genes SLC30A10 and SLC39A8 on Mn concentrations in dentine, a validated biomarker that reflects Mn tissue concentrations early in life. METHODS: The study included 195 children with variable environmental Mn exposure. Mn concentrations in dentine representing fetal, early postnatal and early childhood developmental periods were measured using laser ablation-inductively coupled plasma mass spectrometry...
September 13, 2017: Neurotoxicology
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