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https://www.readbyqxmd.com/read/29140296/microstructure-mechanical-and-tribological-properties-of-oxide-dispersion-strengthened-high-entropy-alloys
#1
Xinyu Liu, Hangboce Yin, Yi Xu
A novel metal matrix composite CrMnFeCoNi with Y₂O₃ as reinforcement phase was designed and manufactured by mechanical alloying and spark plasma sintering. After sintering at 900 °C for 5 min, the microstructure consisted of a FCC matrix and Y₂O₃ nanoparticles. The addition of 0.25 wt % Y₂O₃ increased the room temperature tensile strength of the CrMnFeCoNi base from 868 MPa to 1001 MPa, while the mechanical properties of the addition of 0.5 wt % Y₂O₃ composite decreased. In the meantime, the addition of Y₂O₃ had no significant influence on the coefficient of friction, while the addition of 0...
November 15, 2017: Materials
https://www.readbyqxmd.com/read/29139155/additive-enhanced-crystallization-of-solution-process-for-planar-perovskite-solar-cells-with-efficiency-exceeding-19
#2
Shuai You, Shiqing Bi, Jing Huang, Qiushuang Jia, Yuhe Yuan, Yanjie Xia, Zhenyu Xiao, Zhuzhu Sun, Jiangfeng Liu, Shujie Sun, Zhiqiang Zhao
To reduce intrinsic defect density in perovskite films, various additives are often added into the precursor solution. In this paper, a novel solution approach where isopropanol (IPA) was added into the precursor solution was developed for the preparation of normal planar perovskite solar cells (PSCs). A champion power conversion efficiency (PCE) of 19.70% was achieved with this approach. By adding IPA into the precursor solution, CH3NH3PbI3 perovskite showed better crystallization and stability, indicating improved film quality...
November 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29138881/a-harmonized-immunoassay-with-liquid-chromatography-mass-spectrometry-analysis-in-egg-allergen-determination
#3
Masaomi Nimata, Hideki Okada, Kei Kurihara, Tsukasa Sugimoto, Tsutomu Honjoh, Kazuhiko Kuroda, Takeo Yano, Hirofumi Tachibana, Masahiro Shoji
Food allergy is a serious health issue worldwide. Implementing allergen labeling regulations is extremely challenging for regulators, food manufacturers, and analytical kit manufacturers. Here we have developed an "amino acid sequence immunoassay" approach to ELISA. The new ELISA comprises of a monoclonal antibody generated via an analyte specific peptide antigen and sodium lauryl sulfate/sulfite solution. This combination enables the antibody to access the epitope site in unfolded analyte protein. The newly developed ELISA recovered 87...
November 14, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29138537/development-of-novel-ultrashort-antimicrobial-peptide-nanoparticles-with-potent-antimicrobial-and-antibiofilm-activities-against-multidrug-resistant-bacteria
#4
Ammar Almaaytah, Gubran Khalil Mohammed, Ahmad Abualhaijaa, Qosay Al-Balas
Conventional antibiotics are facing strong microbial resistance that has recently reached critical levels. This situation is leading to significantly reduced therapeutic potential of a huge proportion of antimicrobial agents currently used in clinical settings. Antimicrobial peptides (AMPs) could provide the medical community with an alternative strategy to traditional antibiotics for combating microbial resistance. However, the development of AMPs into clinically useful antibiotics is hampered by their relatively low stability, toxicity, and high manufacturing costs...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29137821/equination-inoculation-of-horsepox-an-early-alternative-to-vaccination-inoculation-of-cowpox-and-the-potential-role-of-horsepox-virus-in-the-origin-of-the-smallpox-vaccine
#5
REVIEW
José Esparza, Livia Schrick, Clarissa R Damaso, Andreas Nitsche
For almost 150 years after Edward Jenner had published the "Inquiry" in 1798, it was generally assumed that the cowpox virus was the vaccine against smallpox. It was not until 1939 when it was shown that vaccinia, the smallpox vaccine virus, was serologically related but different from the cowpox virus. In the absence of a known natural host, vaccinia has been considered to be a laboratory virus that may have originated from mutational or recombinational events involving cowpox virus, variola viruses or some unknown ancestral Orthopoxvirus...
November 11, 2017: Vaccine
https://www.readbyqxmd.com/read/29137676/a-medium-invasiveness-multi-level-patient-s-specific-template-for-pedicle-screw-placement-in-the-scoliosis-surgery
#6
Farhad Azimifar, Kamran Hassani, Amir Hossein Saveh, Farhad Tabatabai Ghomsheh
BACKGROUND: Several methods including free-hand technique, fluoroscopic guidance, image-guided navigation, computer-assisted surgery system, robotic platform and patient's specific templates are being used for pedicle screw placement. These methods have screw misplacements and are not always easy to be applied. Furthermore, it is necessary to expose completely a large portions of the spine in order to access fit entirely around the vertebrae. METHODS: In this study, a multi-level patient's specific template with medium invasiveness was proposed for pedicle screw placement in the scoliosis surgery...
November 14, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29136920/forensic-utility-of-a-nitrogen-and-oxygen-isotope-ratio-time-series-of-ammonium-nitrate-and-its-isolated-ions
#7
Brittany L Grimm, Libby A Stern, Alexander J Lowe
Ammonium nitrate (AN) based fertilizers are inexpensive and easily obtained, characteristics that often lead to their use in homemade explosive devices. The stable nitrogen and oxygen isotope ratios ((15)N/(14)N and (18)O/(16)O, expressed as δ(15)N and δ(18)O) of AN have the potential to aid in forensic investigations by providing supplemental properties for sample-to-sample comparison in materials which are otherwise chemically identical. The forensic utility of stable isotope analyses depends on demonstrated variation between different sources and minimal variation within a source...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136838/a-robotic-magnetic-nanoparticle-solid-phase-extraction-system-coupled-to-flow-batch-analyzer-and-gfaas-for-determination-of-trace-cadmium-in-edible-oils-without-external-pretreatment
#8
Inakã S Barreto, Stefani I E Andrade, Francisco A S Cunha, Marcelo B Lima, Mario Cesar U Araujo, Luciano F Almeida
A lab-made magnetic-mechanical robotic (MMR) system coupled to a flow-batch analyzer (FBA) for magnetic nanoparticles solid phase extraction (MSPE) is presented. As an illustrative application, an NMR-FBA couple was connected to a graphite furnace atomic absorption spectrometer (GFAAS) for quantification of trace cadmium in edible oils. Factors affecting MSPE, such as the amount of adsorbent, the type, concentration and volume of the eluent and elution time were studied. Under the optimized experimental conditions, the interferents studied did not reveal a significant change in the analytical response, indicating that proposed method is selective...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136412/combining-lead-exposure-measurements-and-experts-judgment-through-a-bayesian-framework
#9
Dong-Hee Koh, Ju-Hyun Park, Sang-Gil Lee, Hwan-Cheol Kim, Sangjun Choi, Hyejung Jung, Dong-Uk Park
Objectives: CARcinogen EXposure (CAREX) is a carcinogen-surveillance system employed in many countries. To develop Korean CAREX, the intensity of exposure to lead, as an example, was estimated across industries. Methods: Airborne-lead measurement records were extracted from the work-environment measurement database (WEMD), which is a nationwide workplace-monitoring database. Lead measurements were log-transformed; then, the log-transformed geometric means (LGMs) and log-transformed geometric standard deviations (LGSDs) were calculated for each industry...
November 10, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29135257/field-theoretic-simulations-of-the-distribution-of-nanorods-in-diblock-copolymer-thin-films
#10
Huikuan Chao, Benjamin J Lindsay, Robert A Riggleman
Using block copolymer microphases to guide the self-assembly of nanorods in thin films can give rise to polymeric materials with unique optical, thermal and mechanical properties beyond those found in neat block copolymers. Often the design and manufacture of the materials require exquisite control of the nanorod distribution, which is experimentally challenging due to the large parameter space spanned by this class of materials. Simulation approaches, on the other hand, can access the thermodynamics that contribute to the nanorod distribution and hence offer valuable aide upon the design and manufacture of the materials...
November 14, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29134461/high-throughput-process-development-for-biopharmaceuticals
#11
Abhinav A Shukla, Shahid Rameez, Leslie S Wolfe, Nathan Oien
The ability to conduct multiple experiments in parallel significantly reduces the time that it takes to develop a manufacturing process for a biopharmaceutical. This is particularly significant before clinical entry, because process development and manufacturing are on the "critical path" for a drug candidate to enter clinical development. High-throughput process development (HTPD) methodologies can be similarly impactful during late-stage development, both for developing the final commercial process as well as for process characterization and scale-down validation activities that form a key component of the licensure filing package...
November 14, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29131673/evaluation-of-parasite-egg-and-cyst-recovery-using-devices-designed-for-centrifugal-or-stationary-flotation
#12
Kelsea L Medeiros, Araceli Lucio-Forster, Dwight Douglas Bowman
Two new devices (OT, ST), were recently introduced for the recovery of parasite eggs and cysts for microscopic examination. These devices, two stationary flotation devices, and a standard double-centrifugal sugar-flotation were compared using common flotation solutions and methods recommended by the manufacturers for the recovery of hookworm, ascaridoid, and whipworm eggs from companion animal fecal samples. Additionally, the recovery of Giardia cysts in the OT device using a zinc sulfate versus sodium nitrate solution was evaluated...
November 13, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/29131228/3d-printing-in-chemical-engineering-and-catalytic-technology-structured-catalysts-mixers-and-reactors
#13
REVIEW
Cesar Parra-Cabrera, Clement Achille, Simon Kuhn, Rob Ameloot
Computer-aided fabrication technologies combined with simulation and data processing approaches are changing our way of manufacturing and designing functional objects. Also in the field of catalytic technology and chemical engineering the impact of additive manufacturing, also referred to as 3D printing, is steadily increasing thanks to a rapidly decreasing equipment threshold. Although still in an early stage, the rapid and seamless transition between digital data and physical objects enabled by these fabrication tools will benefit both research and manufacture of reactors and structured catalysts...
November 13, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29130836/composite-3d-printed-scaffold-with-structured-electrospun-nanofibers-promotes-chondrocyte-adhesion-and-infiltration
#14
M Rampichová, E Košt'áková Kuželová, E Filová, J Chvojka, J Šafka, M Pelcl, J Daňková, E Prosecká, M Buzgo, M Plencner, D Lukáš, E Amler
Additive manufacturing, also called 3D printing, is an effective method for preparing scaffolds with defined structure and porosity. The disadvantage of the technique is the excessive smoothness of the printed fibers, which does not support cell adhesion. In the present study, a 3D printed scaffold was combined with electrospun classic or structured nanofibers to promote cell adhesion. Structured nanofibers were used to improve the infiltration of cells into the scaffold. Electrospun layers were connected to 3D printed fibers by gluing, thus enabling the fabrication of scaffolds with unlimited thickness...
November 13, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/29130747/influence-of-storage-and-inter-and-intra-assay-variability-on-the-measurement-of-inflammatory-biomarkers-in-population-based-biobanking
#15
Robert P van Waateringe, Anneke C Muller Kobold, Jana V van Vliet-Ostaptchouk, Melanie M van der Klauw, Jan Koerts, Gabriele Anton, Annette Peters, Gerlinde Trischler, Kirsti Kvaløy, Marit Naess, Vibeke Videm, Kristian Hveem, Melanie Waldenberger, Wolfgang Koenig, Bruce H R Wolffenbuttel
BACKGROUND: In the present study, we examined the effect of sample storage on the reproducibility of several inflammatory biomarkers, including high-sensitivity C-reactive protein (hsCRP), high-sensitivity interleukin-6 (hsIL6), and high-sensitivity tumor necrosis factor alpha (hsTNFα). In addition, we assessed inter- and intra-assay variability between collaborating biobanks. METHODS: In total, 240 fasting plasma samples were obtained from the LifeLines biobank...
November 13, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/29130721/the-nutritional-limitations-of-plant-based-beverages-in-infancy-and-childhood
#16
Isidro Vitoria
Breastfeeding, infant formula and cow's milk are basic foods in infant nutrition. However, they are being increasingly replaced either totally or partially by plant-based beverages.The composition of 164 plant-based beverages available in Spain was reviewed based on the nutritional labeling of the package and the manufacturers' webpages. This was compared to the composition of cow's milk and infant formula. In addition, the nutritional disease associated with consumption of plant-based beverages in infants and children was reviewed by means of a literature search in Medline and Embase since 1990 based on the key words "plant-based beverages" or "rice beverages" or "almond beverages" or "soy beverages" and "infant" or "child"...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29130436/hearing-technology-use-and-management-in-school-age-children-reports-from-data-logs-parents-and-teachers
#17
Samantha J Gustafson, Todd A Ricketts, Anne Marie Tharpe
BACKGROUND: Consistency of hearing aid and remote microphone system use declines as school-age children with hearing loss age. One indicator of hearing aid use time is data logging, another is parent report. Recent data suggest that parents overestimate their children's hearing aid use time relative to data logging. The potential reasons for this disparity remain unclear. Because school-age children spend the majority of their day away from their parents and with their teachers, reports from teachers might serve as a valuable and additional tool for estimating hearing aid use time and management...
November 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29130351/the-gene-therapy-resource-program-a-decade-of-dedication-to-translational-research-by-the-national-heart-lung-and-blood-institute
#18
Terence R Flotte, Eric Daniels, Janet Benson, Jenee M Bevett-Rose, Kenneth Cornetta, Margaret Diggins, Julie Johnston, Susan Sepelak, Johannes Van Der Loo, James M Wilson, Cheryl L McDonald
Over a ten-year period, the Gene Therapy Resource Program (GTRP) of the National Heart Lung and Blood Institute (NHLBI) has provided a set of core services to investigators to facilitate the clinical translation of gene therapy. These services have included a preclinical (research-grade) vector production core; current Good Manufacturing Practice (cGMP) clinical-grade vector cores for recombinant adeno-associated virus (rAAV) and lentivirus vectors; a pharmacology and toxicology core; and a coordinating center to manage program logistics and to provide regulatory and financial support to early phase clinical trials...
November 12, 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/29128949/elvisml-an-open-data-format-for-the-exchange-and-storage-of-electrophysiological-data-in-ophthalmology
#19
Torsten Strasser, Tobias Peters, Herbert Jägle, Eberhart Zrenner
PURPOSE: The ISCEV standards and recommendations for electrophysiological recordings in ophthalmology define a set of protocols with stimulus parameters, acquisition settings, and recording conditions, to unify the data and enable comparability of results across centers. Up to now, however, there are no standards to define the storage and exchange of such electrophysiological recordings. The aim of this study was to develop an open standard data format for the exchange and storage of visual electrophysiological data (ElVisML)...
November 11, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29128750/reduction-of-interferences-in-the-analysis-of-children-s-dimetapp-using-ultraviolet-spectroscopy-data-and-target-factor-analysis
#20
Huggins Z Msimanga, Truong Thach Ho Lam, Nathaniel Latinwo, Mihyang Kristy Song, Newsha Tavakoli
A calibration matrix has been developed and successfully applied to quantify actives in Children's Dimetapp®, a cough mixture whose active components suffer from heavy spectral interference. High-performance liquid chromatography/photodiode array instrument was used to identify the actives and any other UV-detectable excipients that might contribute to interferences. The instrument was also used to obtain reference data on the actives, instead of relying on the manufacturer's claims. Principal component analysis was used during the developmental stages of the calibration matrix to highlight any mismatch between the calibration and sample spectra, making certain that "apples" were not compared with "oranges"...
November 3, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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