Le Yu, Xiaona Zhu, Kang Peng, Huimin Qin, Kexin Yang, Fang Cai, Ji Hu, Ye Zhang
Pain, a comorbidity of anxiety disorders, causes substantial clinical, social, and economic burdens. Emerging evidence suggests that propofol, the most commonly used general anesthetic, may regulate psychological disorders; however, its role in pain-associated anxiety is not yet described. This study investigates the therapeutic potential of a single dose of propofol (100 mg kg-1 ) in alleviating pain-associated anxiety and examines the underlying neural mechanisms. In acute and chronic pain models, propofol decreased anxiety-like behaviors in the elevated plus maze (EPM) and open field (OF) tests...
April 19, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)