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https://www.readbyqxmd.com/read/28240006/effects-of-six-weeks-endurance-training-and-aloe-vera-supplementation-on-cox-2-and-vegf-levels-in-mice-with-breast-cancer
#1
Saeed Shirali, Alireza Barari, Seyed Ahmad Hosseini, Elaheh Khodadi
The aim of this study was to determine effects of six weeks endurance training and Aloe Vera supplementation on COX-2 and VEGF levels in mice with breast cancer. For this purpose, 35 rats were randomly divided into 5 groups: control (healthy) and 4 cancer groups: control (cancer only), training, Aloe Vera and Aloe Vera + training. Breast cancer tumors were generated in mice by implantind. The training program comprised six weeks of swimming training accomplished in three sessions per week. Training time started with 10 minutes on the first day and increased to 60 minutes in the second week and the water flow rate was increased from 7 to 15 liters per minute at a constant rate...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28239802/anesthetic-management-of-patients-with-dilated-cardiomyopathy-for-noncardiac-surgery
#2
C-Q Chen, X Wang, J Zhang, S-M Zhu
Anesthetic management of patients with dilated cardiomyopathy (DCM) is a challenge to the anesthesiologist, due to poor left systolic function, ventricular enlargement, risk of malignant arrhythmias and sudden cardiac death. Therefore, preoperative assessment and appropriate anesthetic management are important in patients with DCM. This review describes the preoperative evaluation and anesthesia considerations of patients with DCM undergoing non-cardiac surgery. Patient pathophysiology and clinical status, such as ventricular function, degree of myocardial fibrosis, resting heart rate and high-sensitivity C-reactive protein can affect survival rates...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239332/characterization-of-the-circumlimbal-suture-model-of-chronic-iop-elevation-in-mice-and-assessment-of-changes-in-gene-expression-of-stretch-sensitive-channels
#3
Da Zhao, Christine T O Nguyen, Vickie H Y Wong, Jeremiah K H Lim, Zheng He, Andrew I Jobling, Erica L Fletcher, Holly R Chinnery, Algis J Vingrys, Bang V Bui
To consider whether a circumlimbal suture can be used to chronically elevate intraocular pressure (IOP) in mice and to assess its effect on retinal structure, function and gene expression of stretch sensitive channels. Anesthetized adult C57BL6/J mice had a circumlimbal suture (10/0) applied around the equator of one eye. In treated eyes (n = 23) the suture was left in place for 12 weeks whilst in sham control eyes the suture was removed at day two (n = 17). Contralateral eyes served as untreated controls. IOP was measured after surgery and once a week thereafter...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28238830/blood-brain-barrier-disruption-was-less-under-isoflurane-than-pentobarbital-anesthesia-via-a-pi3k-akt-pathway-in-early-cerebral-ischemia
#4
Oak Z Chi, Scott J Mellender, Geza K Kiss, Xia Liu, Harvey R Weiss
One of the important factors altering the degree of blood-brain barrier (BBB) disruption in cerebral ischemia is the anesthetic used. The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway has been reported to be involved in modulating BBB permeability and in isoflurane induced neuroprotection. This study was performed to compare the degree of BBB disruption in focal cerebral ischemia under isoflurane vs pentobarbital anesthesia and to determine whether inhibition of PI3K/Akt would affect the disruption in the early stage of focal cerebral ischemia...
February 23, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28238671/cardiac-autonomic-ganglia-ablation-suppresses-atrial-fibrillation-in-a-canine-model-of-acute-intermittent-hypoxia
#5
Xiaomei Yu, Zhibing Lu, Wenbo He, Bo He, Ruisong Ma, Jing Xie, Hong Jiang
BACKGROUND: Atrial fibrillation (AF) is associated with hypoxia in which cardiac autonomic nerve system (ANS) plays an important role. Our previous studies indicated that ANS is activated in an intermittent hypoxia model and contributes to AF initiation. This study aimed to investigate the effects of cardiac ganglionated plexus (GP) ablation on AF in this model. METHODS AND RESULTS: In thirteen anesthetized male dogs, GP ablation was applied after 1h of intermittent hypoxia in the first group (n=7) and before that in the second group (n=6)...
February 23, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28238585/recovery-from-rocuronium-induced-neuromuscular-block-was-longer-in-the-larynx-than-in-the-pelvic-limb-of-anesthetized-dogs
#6
Daniel M Sakai, Manuel Martin-Flores, Marta Romano, Chia T Tseng, Luis Campoy, Robin D Gleed, Jonathan Cheetham
OBJECTIVE: To determine if neuromuscular monitoring at the pelvic limb accurately reflects neuromuscular function in the larynx after administration of rocuronium in anesthetized dogs. STUDY DESIGN: Prospective experimental study. ANIMALS: Six healthy Beagle dogs. METHODS: Anesthesia was maintained in dogs with isoflurane and a continuous infusion of dexmedetomidine. Rocuronium (0.6 mg kg(-1)) was administered intravenously to induce neuromuscular block...
January 7, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28238448/visually-guided-tube-thoracostomy-insertion-comparison-to-standard-of-care-in-a-large-animal-model
#7
Matthew C Hernandez, David Vogelsang, Jeff R Anderson, Cornelius A Thiels, Gregory Beilman, Martin D Zielinski, Johnathon M Aho
INTRODUCTION: Tube thoracostomy (TT) is a lifesaving procedure for a variety of thoracic pathologies. The most commonly utilized method for placement involves open dissection and blind insertion. Image guided placement is commonly utilized but is limited by an inability to see distal placement location. Unfortunately, TT is not without complications. We aim to demonstrate the feasibility of a disposable device to allow for visually directed TT placement compared to the standard of care in a large animal model...
February 20, 2017: Injury
https://www.readbyqxmd.com/read/28238186/effects-of-hallucinogens-on-neuronal-activity
#8
L Lladó-Pelfort, P Celada, M S Riga, E Troyano-Rodríguez, N Santana, F Artigas
Hallucinogens evoke sensory, perceptual, affective, and cognitive effects that may be useful to understand the neurobiological basis of mood and psychotic disorders. The present chapter reviews preclinical research carried out in recent years in order to better understand the action of psychotomimetic agents such as the noncompetitive NMDA receptor (NMDA-R) antagonists and serotonergic hallucinogens. Our studies have focused on the mechanisms through which these agents alter cortical activity. Noncompetitive NMDA-R antagonists, such as phencyclidine (PCP) and MK-801 (dizocilpine), as well as the serotonergic hallucinogens DOI and 5-MeO-DMT, produce similar effects on cellular and population activity in prefrontal cortex (PFC); these effects include alterations of pyramidal neuron discharge (with an overall increase in firing), as well as a marked attenuation of the low frequency oscillations (0...
February 26, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28238025/anesthetic-management-of-abdominal-radical-trachelectomy-for-uterine-cervical-cancer-during-pregnancy
#9
Jun Terukina, Misako Takamatsu, Takayuki Enomoto, Hiroshi Baba
Abdominal radical trachelectomy has been identified as a surgical option for fertility preservation in cervical cancer patients, particularly in pregnant women who strongly desire to continue their pregnancy. Since this procedure requires operating in the uterus, the hardness of the uterus can affect the ease of surgery. Generally, sevoflurane is used for anesthesia in non-obstetric surgery for pregnant women because uterine relaxation is advantageous for uterine blood flow maintenance. However, the use of sevoflurane during radical trachelectomy has not been thoroughly evaluated...
February 25, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28237801/inactivation-of-the-medial-mammillary-nucleus-attenuates-theta-rhythm-activity-in-the-hippocampus-in-urethane-anesthetized-rats
#10
Witold Żakowski, Łukasz Braszka, Piotr Zawistowski, Jolanta Orzeł-Gryglewska, Edyta Jurkowlaniec
Although the importance of the mammillary body for memory and learning processes is well known, its exact role has remained vague. The fact, that many neurons in one nucleus of the mammillary body in rats, i.e. the medial mammillary nucleus (MM), fires according with hippocampal theta rhythm, makes this structure crucial for a theta rhythm signaling in so-called extended hippocampal system. These neurons are driven by descending projections from the hippocampal formation, but it is still unknown whether the mammillary body only conveys theta rhythm or may also modulate it...
February 22, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28237684/effects-of-dexmedetomidine-combined-with-ropivacaine-on-sciatic-and-femoral-nerve-blockade-in-dogs
#11
Thomas A Trein, Beatriz P Floriano, Juliana T Wagatsuma, Joana Z Ferreira, Guilherme L da Silva, Paulo S P Dos Santos, Sílvia H V Perri, Valéria Nls Oliva
OBJECTIVE: To evaluate motor and sensory blockade of combining dexmedetomidine with ropivacaine, administered perineurally or systemically, for femoral and sciatic nerve blocks in conscious dogs. STUDY DESIGN: Randomized, controlled, experimental study. ANIMALS: Seven healthy Beagle dogs, aged 3.3 ± 0.1 years and weighing 11.0 ± 2.4 kg. METHODS: Dogs were anesthetized with isoflurane on three separate occasions for unilateral femoral and sciatic nerve blocks and were administered the following treatments in random order: perineural ropivacaine 0...
February 22, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28237652/impact-of-epinephrine-contained-in-local-anesthetic-solution-on-serum-lactate-level-during-orthognathic-surgery
#12
Hidetaka Kuroda, Gaku Kawamura, Manabu Soya, Takayuki Kitamura, Tatsuya Ichinohe, Yoshitsugu Yamada
PURPOSE: There have been many discussions of a relation between endogenous and exogenous epinephrine and hyperlactatemia. This study aimed to identify the impact of epinephrine contained in a local anesthetic solution on serum lactate levels in patients who underwent orthognathic surgery. MATERIALS AND METHODS: This study was a retrospective record review of cases of maxillary and mandibular osteotomy at the Tokyo University Hospital (Tokyo, Japan) from January 2006 through December 2014...
February 3, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28236873/perianesthetic-refractory-anaphylactic-shock-with-cefuroxime-in-a-patient-with-history-of-penicillin-allergy-on-multiple-antihypertensive-medications
#13
Deb Sanjay Nag, Devi Prasad Samaddar, Shashi Kant, Pratap Rudra Mahanty
We report a case of perianesthetic refractory anaphylactic shock with cefuroxime in a patient with history of penicillin allergy on regular therapy with atenolol, losartan, prazosin and nicardipine. Severe anaphylactic shock was only transiently responsive to 10mL of (1:10,000) epinephrine and needed norepinephrine and dopamine infusion. Supportive therapy with vasopressors and inotropes along with mechanical ventilation for the next 24hours resulted in complete recovery. She was successfully operated upon 2 weeks later with the same anesthetic drugs but intravenous ciprofloxacin as the alternative antibiotic for perioperative prophylaxis...
March 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/28236871/anesthetic-management-of-an-infant-with-giant-abdominal-neuroblastoma
#14
Manuel Ángel Gómez-Ríos, Federico Curt Nuño, Purísima Barreto-Calvo
Neuroblastoma is the most common, non-central nervous system tumor of childhood. It has the potential to synthesize catecholamines. However, the presences of hypertension are uncommon. We report the perioperative management of a 15-month-old infant with giant abdominal neuroblastoma who presented severe hypertension. The pathophysiological alterations of neuroblastoma are reviewed and perioperative management presented.
March 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/28236866/accuracy-of-a-smartphone-to-test-laryngoscope-s-light-and-an-audit-to-our-laryngoscopes-using-an-iso-standard
#15
Diogo Alcino de Abreu Ribeiro Carvalho Machado, Dina da Assunção Azevedo Esteves, Pedro Manuel Araújo de Sousa Branca
BACKGROUND AND OBJECTIVES: Laryngoscope is a key tool in anesthetic practice. Direct laryngoscopy is a crucial moment and inadequate laryngoscope's light can lead to catastrophic consequences. From our experience laryngoscope's light is assessed in a subjective manner and we believe a more precise evaluation should be used. Our objective is to compare the accuracy of a smartphone compared to a lux meter. Secondly we audited our Operating Room laryngoscopes. METHODS: We designed a pragmatic study, using as primary outcome the accuracy of a smartphone compared to the lux meter...
March 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/28236766/oxidative-stress-metabolomics-profiling-and-mechanism-of-local-anesthetic-induced-cell-death-in-yeast
#16
Cory H T Boone, Ryan A Grove, Dana Adamcova, Javier Seravalli, Jiri Adamec
The World Health Organization designates lidocaine as an essential medicine in healthcare, greatly increasing the probability of human exposure. Its use has been associated with ROS generation and neurotoxicity. Physiological and metabolomic alterations, and genetics leading to the clinically observed adverse effects have not been temporally characterized. To study alterations that may lead to these undesirable effects, Saccharomyces cerevisiae grown on aerobic carbon sources to stationary phase was assessed over 6h...
February 3, 2017: Redox Biology
https://www.readbyqxmd.com/read/28235893/single-neurons-in-the-avian-auditory-cortex-encode-individual-identity-and-propagation-distance-in-naturally-degraded-communication-calls
#17
Solveig C Mouterde, Julie E Elie, Nicolas Mathevon, Frédéric E Theunissen
One of the most complex tasks performed by sensory systems is "scene analysis": the interpretation of complex signals as behaviorally relevant objects. The study of this problem, universal to species and sensory modalities, is particularly challenging in audition, where sounds from various sources and localizations, degraded by propagation through the environment, sum to form a single acoustical signal. Here we investigated in a songbird model, the zebra finch, the neural substrate for ranging and identifying a single source...
February 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28235576/lidocaine-multivalent-ion-complex-as-a-potential-strategy-for-prolonged-local-anesthesia
#18
You Jin Jang, Jin Ho Lee, Tae Beom Seo, Se Heang Oh
Local anesthetics are adopted in clinical practice to manage the perioperative and/or postoperative pain. However, their relatively short duration of action limit their ability to meet clinical needs. Herein, we prepared a lidocaine/multivalent ion complex (icLD) using aqueous solutions containing positively charged LD and a multivalent counter-ion as a system for producing prolonged anesthesia. The results of the in vitro and in vivo experiments indicated that the icLD facilitates prolonged LD release even without adjuvants and thus provides nerve blockade for a long duration of action (∼14hrs) without further increase in neurotoxicity than the LD itself...
February 21, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28235534/case-reports-should-we-do-away-with-them
#19
Aynur Camkiran Firat, Coskun Araz, Zeynep Kayhan
STUDY OBJECTIVE: There has been a gradual decline in the number of case reports published in leading medical journals in recent years. Since case reports are not highly cited they have an adverse effect on the journal impact factor. On the other hand sharing new experiences, challenges, or discoveries with colleagues is essential for medical community. Should case reports be eliminated from the journals or published only in journals devoted to case reports? DESIGN: Observational study...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28235533/comparison-of-ropivacaine-with-and-without-fentanyl-vs-bupivacaine-with-fentanyl-for-postoperative-epidural-analgesia-in-bilateral-total-knee-replacement-surgery
#20
Ashish Khanna, Rakesh Saxena, Amitabh Dutta, Neelam Ganguly, Jayashree Sood
STUDY OBJECTIVES: Pain after total knee replacement (TKR) interferes with early rehabilitation. Although the use of epidural bupivacaine in post-TKR patients is associated with effective analgesia, the associated motor blockade effect delays functional recovery. We compared analgesic efficacy and side effects of postoperative patient-controlled epidural analgesia (PCEA) with plain ropivacaine 0.1% with/without fentanyl 2.5 μg/mL vs plain bupivacaine 0.0625% with fentanyl 2.5 μg/mL in patients undergoing bilateral TKR...
February 2017: Journal of Clinical Anesthesia
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