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https://www.readbyqxmd.com/read/29453548/-big-data-from-clinical-routine
#1
REVIEW
U Mansmann
BACKGROUND: Over the past 100 years, evidence-based medicine has undergone several fundamental changes. Through the field of physiology, medical doctors were introduced to the natural sciences. Since the late 1940s, randomized and epidemiological studies have come to provide the evidence for medical practice, which led to the emergence of clinical epidemiology as a new field in the medical sciences. Within the past few years, big data has become the driving force behind the vision for having a comprehensive set of health-related data which tracks individual healthcare histories and consequently that of large populations...
February 16, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29446035/sorting-through-the-safety-data-haystack-using-machine-learning-to-identify-individual-case-safety-reports-in-social-digital-media
#2
Shaun Comfort, Sujan Perera, Zoe Hudson, Darren Dorrell, Shawman Meireis, Meenakshi Nagarajan, Cartic Ramakrishnan, Jennifer Fine
INTRODUCTION: There is increasing interest in social digital media (SDM) as a data source for pharmacovigilance activities; however, SDM is considered a low information content data source for safety data. Given that pharmacovigilance itself operates in a high-noise, lower-validity environment without objective 'gold standards' beyond process definitions, the introduction of large volumes of SDM into the pharmacovigilance workflow has the potential to exacerbate issues with limited manual resources to perform adverse event identification and processing...
February 14, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29441511/-cardiology-telemedicine-solutions-opinion-of-the-committee-of-informatics-and-telemedicine-of-polish-society-of-cardiology-section-of-non-invasive-electrocardiology-and-telemedicine-of-polish-society-of-cardiology-and-clinical-sciences-committee-of-the
#3
Ryszard Piotrowicz, Paweł Krzesiński, Paweł Balsam, Maciej Kempa, Renata Główczyńska, Marcin Grabowski, Łukasz Kołtowski, Ewa Lewicka, Michał Peller, Ewa Piotrowicz, Jakub Podolec, Adam Stańczyk, Justyna Zajdel, Grzegorz Opolski
For several years, we have observed the dynamic development of technologies that allow patients to access medical care from the comfort of their homes, without direct contact with the doctor. Innovative solutions based on telemedicine improve care coordination and communication among clinicians, patients, and their families, as well as increases patients' security and gives them greater independence, thus eliminating health care inequalities. The rapidly growth of telemedicine and the adoption of new technologies in clinical practice is also observed in Poland...
February 14, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29401537/european-federation-for-medical-informatics-efmi-a-brief-outline
#4
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29401536/north-american-medical-informatics-nami
#5
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29396851/medications-that-relax-the-lower-oesophageal-sphincter-and-risk-of-oesophageal-cancer-an-analysis-of-two-independent-population-based-databases
#6
Andrew D Spence, John Busby, Peter Murchie, Andrew T Kunzmann, Úna C McMenamin, Helen G Coleman, Brian T Johnston, Michael A O'Rorke, Liam J Murray, Lisa Iversen, Amanda J Lee, Chris R Cardwell
Excessive lower oesophageal sphincter relaxation increases gastro-oesophageal acid reflux, an oesophageal adenocarcinoma risk factor. Medications that relax this sphincter (benzodiazepines, calcium channel blockers, nitrates, β2 agonists and xanthines) could promote cancer. These medications were investigated in two independent datasets. In the Scottish Primary Care Clinical Informatics Unit (PCCIU) database, a nested case-control study of oesophageal cancer was performed using GP prescription records. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CIs) for medication use and oesophageal cancer...
February 3, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29389426/registry-assessment-of-peripheral-interventional-devices-rapid-registry-assessment-of-peripheral-interventional-devices-core-data-elements
#7
W Schuyler Jones, Mitchell W Krucoff, Pablo Morales, Rebecca W Wilgus, Anne H Heath, Mary F Williams, James E Tcheng, J Danica Marinac-Dabic, Misti L Malone, Terrie L Reed, Rie Fukaya, Robert A Lookstein, Nobuhiro Handa, Herbert D Aronow, Daniel J Bertges, Michael R Jaff, Thomas T Tsai, Joshua A Smale, Margo J Zaugg, Robert J Thatcher, Jack L Cronenwett
OBJECTIVE: The current state of evaluating patients with peripheral artery disease and more specifically of evaluating medical devices used for peripheral vascular intervention (PVI) remains challenging because of the heterogeneity of the disease process, the multiple physician specialties that perform PVI, the multitude of devices available to treat peripheral artery disease, and the lack of consensus about the best treatment approaches. Because PVI core data elements are not standardized across clinical care, clinical trials, and registries, aggregation of data across different data sources and physician specialties is currently not feasible...
February 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29369828/development-and-external-validation-of-an-automated-computer-aided-risk-score-for-predicting-sepsis-in-emergency-medical-admissions-using-the-patient-s-first-electronically-recorded-vital-signs-and-blood-test-results
#8
Muhammad Faisal, Andy Scally, Donald Richardson, Kevin Beatson, Robin Howes, Kevin Speed, Mohammed A Mohammed
OBJECTIVES: To develop a logistic regression model to predict the risk of sepsis following emergency medical admission using the patient's first, routinely collected, electronically recorded vital signs and blood test results and to validate this novel computer-aided risk of sepsis model, using data from another hospital. DESIGN: Cross-sectional model development and external validation study reporting the C-statistic based on a validated optimized algorithm to identify sepsis and severe sepsis (including septic shock) from administrative hospital databases using International Classification of Diseases, 10th Edition, codes...
January 24, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29367497/registry-assessment-of-peripheral-interventional-devices-rapid-%C3%A3-registry-assessment-of-peripheral-interventional-devices-core-data-elements
#9
W Schuyler Jones, Mitchell W Krucoff, Pablo Morales, Rebecca W Wilgus, Anne H Heath, Mary F Williams, James E Tcheng, J Danica Marinac-Dabic, Misti L Malone, Terrie L Reed, Rie Fukaya, Robert Lookstein, Nobuhiro Handa, Herbert D Aronow, Daniel J Bertges, Michael R Jaff, Thomas T Tsai, Joshua A Smale, Margo J Zaugg, Robert J Thatcher, Jack L Cronenwett, Durham Nc, Silver Spring Md, Tokyo Japan, New York Ny, Providence Ri, Burlington Vt, Newton Mass, Denver Colo, Tempe Ariz, Santa Clara Calif, Minneapolis Minn, Lebanon Nh
BACKGROUND: The current state of evaluating patients with peripheral artery disease and more specifically of evaluating medical devices used for peripheral vascular intervention (PVI) remains challenging because of the heterogeneity of the disease process, the multiple physician specialties that perform PVI, the multitude of devices available to treat peripheral artery disease, and the lack of consensus about the best treatment approaches. Because PVI core data elements are not standardized across clinical care, clinical trials, and registries, aggregation of data across different data sources and physician specialties is currently not feasible...
January 25, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29365340/towards-implementation-of-omop-in-a-german-university-hospital-consortium
#10
C Maier, L Lang, H Storf, P Vormstein, R Bieber, J Bernarding, T Herrmann, C Haverkamp, P Horki, J Laufer, F Berger, G Höning, H W Fritsch, J Schüttler, T Ganslandt, H U Prokosch, M Sedlmayr
BACKGROUND:  In 2015, the German Federal Ministry of Education and Research initiated a large data integration and data sharing research initiative to improve the reuse of data from patient care and translational research. The Observational Medical Outcomes Partnership (OMOP) common data model and the Observational Health Data Sciences and Informatics (OHDSI) tools could be used as a core element in this initiative for harmonizing the terminologies used as well as facilitating the federation of research analyses across institutions...
January 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29363432/a-bioinformatics-potpourri
#11
EDITORIAL
Christian Schönbach, Jinyan Li, Lan Ma, Paul Horton, Muhammad Farhan Sjaugi, Shoba Ranganathan
The 16th International Conference on Bioinformatics (InCoB) was held at Tsinghua University, Shenzhen from September 20 to 22, 2017. The annual conference of the Asia-Pacific Bioinformatics Network featured six keynotes, two invited talks, a panel discussion on big data driven bioinformatics and precision medicine, and 66 oral presentations of accepted research articles or posters. Fifty-seven articles comprising a topic assortment of algorithms, biomolecular networks, cancer and disease informatics, drug-target interactions and drug efficacy, gene regulation and expression, imaging, immunoinformatics, metagenomics, next generation sequencing for genomics and transcriptomics, ontologies, post-translational modification, and structural bioinformatics are the subject of this editorial for the InCoB2017 supplement issues in BMC Genomics, BMC Bioinformatics, BMC Systems Biology and BMC Medical Genomics...
January 19, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29313057/regional-differences-in-thrombectomy-rates-secondary-use-of-billing-codes-in-the-miracum-medical-informatics-for-research-and-care-in-university-medicine-consortium
#12
Christian Haverkamp, Thomas Ganslandt, Petar Horki, Martin Boeker, Arnd Dörfler, Stefan Schwab, Joachim Berkefeld, Waltraud Pfeilschifter, Wolf-Dirk Niesen, Karl Egger, Manfred Kaps, Marc A Brockmann, Eva Neumaier-Probst, Kristina Szabo, Martin Skalej, Siegfried Bien, Christoph Best, Hans-Ulrich Prokosch, Horst Urbach
BACKGROUND AND PURPOSE: Mechanical thrombectomy, in addition to intravenous (i.v.) thrombolysis is recommended for treatment of acute stroke in patients with large vessel occlusions (LVO) in the anterior circulation up to 6 h after symptom onset. We compared thrombectomy rates of eight university hospitals of the MIRACUM consortium to analyze the implementation of this guideline in clinical routine. METHODS: Anonymized billing data in a standardized format were loaded into a local i2b2 data warehouse by applying already existing extract, transform and load (ETL) routines...
January 8, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29306877/process-evaluation-of-the-data-driven-quality-improvement-in-primary-care-dqip-trial-quantitative-examination-of-variation-between-practices-in-recruitment-implementation-and-effectiveness
#13
Tobias Dreischulte, Aileen Grant, Adrian Hapca, Bruce Guthrie
OBJECTIVES: The cluster randomised trial of the Data-driven Quality Improvement in Primary Care (DQIP) intervention showed that education, informatics and financial incentives for general medical practices to review patients with ongoing high-risk prescribing of non-steroidal anti-inflammatory drugs and antiplatelets reduced the primary end point of high-risk prescribing by 37%, where both ongoing and new high-risk prescribing were significantly reduced. This quantitative process evaluation examined practice factors associated with (1) participation in the DQIP trial, (2) review activity (extent and nature of documented reviews) and (3) practice level effectiveness (relative reductions in the primary end point)...
January 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29306660/clinical-impact-of-21-gene-recurrence-score-test-within-the-veterans-health-administration-utilization-and-receipt-of-guideline-concordant-care
#14
Leland E Hull, Julie A Lynch, Brygida B Berse, Scott L DuVall, Danielle S Chun, Vicki L Venne, Olga V Efimova, Michael S Icardi, Michael J Kelley
INTRODUCTION: Ensuring guideline-concordant cancer care is a Department of Veterans Affairs (VA) priority, especially as the number of breast cancer patients at VA medical centers (VAMCs) grows. We assessed the utilization and clinical impact of the 21-gene Recurrence Score test, which predicts 10-year risk of breast cancer recurrence and the likelihood of chemotherapy benefit, on veterans newly diagnosed with breast cancer. PATIENTS AND METHODS: We conducted a retrospective cohort study using 2011-2012 VA Central Cancer Registry, chart review, and laboratory test data...
November 29, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29298192/helping-older-adults-improve-their-medication-experience-home-by-addressing-medication-regimen-complexity-in-home-healthcare
#15
Orla C Sheehan, Hadi Kharrazi, Kimberly J Carl, Bruce Leff, Jennifer L Wolff, David L Roth, Jennifer Gabbard, Cynthia M Boyd
In skilled home healthcare (SHHC), communication between nurses and physicians is often inadequate for medication reconciliation and needed changes to the medication regimens are rarely made. Fragmentation of electronic health record (EHR) systems, transitions of care, lack of physician-nurse in-person contact, and poor understanding of medications by patients and their families put patients at risk for serious adverse outcomes. The aim of this study was to develop and test the HOME tool, an informatics tool to improve communication about medication regimens, share the insights of home care nurses with physicians, and highlight to physicians and nurses the complexity of medication schedules...
January 2018: Home Healthcare Now
https://www.readbyqxmd.com/read/29288819/stem-cell-transplantation-and-informatics-current-considerations
#16
REVIEW
Roy B Jones, Charles Martinez, Navneet S Majhail, Matthew Prestegaard, Martin Maiers, Mitchell Horwitz, Krishna Komanduri
Informatics strategies and applications available to stem cell transplant (SCT) programs are diverse and changing rapidly. While most hospitals have electronic medical records (EMR), few are equipped with specialized SCT applications. Most EMR do not contain critical elements to support SCT practice and research. Strategies to optimize IT resources to support SCT programs are reviewed, and technical and workflow support are discussed. Guidance and rationale for the use of both SCT applications and EMR are emphasized...
December 27, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29285339/medium-chain-acyl-coa-dehydrogenase-deficiency-in-a-premature-infant
#17
Steven F Dobrowolski, Lina Ghaloul-Gonzalez, Jerry Vockley
Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is identified by newborn screening (NBS). The natural history of MCADD includes metabolic decompensation with hypoglycemia, hyperammonemia, seizures, coma, and death. NBS enables expectant management thus severe symptoms are rare in managed patients. We report premature birth of an MCADD affected infant and resultant management challenges. Nutritional support advanced from parenteral nutrition at 24 hours to enteral feeds. A NBS sample was collected day 2, positive results for MCADD was reported day six, and diagnostic tests were performed day seven...
November 21, 2017: Pediatric Reports
https://www.readbyqxmd.com/read/29284923/a-prerequisite-for-patient-centred-care-is-empowering-and-engaging-patients-in-the-digital-health-report-from-efmi-special-topic-conference-stc-2017
#18
Simon de Lusignan
The European Federation for Medical Informatics (EFMI) held its Special Topic Conference (STC) in October 2017 in Israel. EFMI holds STC's to focus on a particular issue, whereas its major annual conference Medical Informatics Europe (MIE) has a much wider remit. This conference challenged the informatics community to engage patients in digital health. Examples of the gap in digital engagementfrom the conference contributions include: An app to connect parents to a paediatric emergency department was presented...
December 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/29284922/the-most-influential-scientists-in-the-development-of-medical-informatics-19-john-bryden
#19
REVIEW
Izet Masic
No abstract text is available yet for this article.
December 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/29284909/evaluation-of-founding-members-of-the-international-academy-of-health-sciences-informatics-iahsi-based-on-google-scholar-and-scopus-parameters
#20
Izet Masic
Introduction: The International Academy of Health Sciences Informatics (IAHSI) is established by International Medical Informatics Association (IMIA) which is the world body for health and biomedical informatics. The Academy will serve as an honor society that recognizes expertise in biomedical and health informatics internationally. Academy membership will be one of the highest honors in the international field of biomedical and health informatics. Aim: To present scientometric analysis of founding members of the International Academy of Health Sciences Informatics, to evaluate members and their scientific rating...
December 2017: Acta Informatica Medica: AIM
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