Xiaotian Ju, Akimichi Nagashima, Anna Dvorkin-Gheva, Jennifer Wattie, Karen Howie, Christiane Whetstone, Maral Ranjbar, Ruth Cusack, Reina Ditta, Guillaume Paré, Imran Satia, Paul M O'Byrne, Gail M Gauvreau, Roma Sehmi
RATIONALE: In asthma, sputum group 2 innate lymphoid cells (ILC2) are activated within 7h after allergen challenge. Neuroimmune interactions mediate rapid host responses at mucosal interfaces. In murine models of asthma, lung ILC2 co-localize to sensory neuronal termini expressing the neuropeptide, neuromedin U (NMU) and NMU stimulates type 2 cytokines secretion by ILC2 with additive effects to alarmins, in vitro . OBJECTIVES: Investigate effect of NMU/NMUR1 axis on early activation of ILC2 in asthma...
April 10, 2024: American Journal of Respiratory and Critical Care Medicine