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https://www.readbyqxmd.com/read/27921079/data-file-of-a-deep-proteome-analysis-of-the-prefrontal-cortex-in-aged-mice-with-progranulin-deficiency-or-neuronal-overexpression-of-progranulin
#1
Juliana Heidler, Stefanie Hardt, Ilka Wittig, Irmgard Tegeder
Progranulin deficiency is associated with neurodegeneration in humans and in mice. The mechanisms likely involve progranulin-promoted removal of protein waste via autophagy. We performed a deep proteomic screen of the pre-frontal cortex in aged (13-15 months) female progranulin-deficient mice (GRN(-/-)) and mice with inducible neuron-specific overexpression of progranulin (SLICK-GRN-OE) versus the respective control mice. Proteins were extracted and analyzed per liquid chromatography/mass spectrometry (LC/MS) on a Thermo Scientific™ Q Exactive Plus equipped with an ultra-high performance liquid chromatography unit and a Nanospray Flex Ion-Source...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27921076/yeast-2-hybrid-data-file-showing-progranulin-interactions-in-human-fetal-brain-and-bone-marrow-libraries
#2
Irmgard Tegeder
Progranulin deficiency in humans is associated with neurodegeneration. Its mechanisms are not yet fully understood. We performed a Yeast-2-Hybrid screen using human full-length progranulin as bait to assess the interactions of progranulin. Progranulin was screened against human fetal brain and human bone marrow libraries using the standard Matchmaker technology (Clontech). This article contains the full Y2H data table, including blast results and sequences, a sorted table according to selection criteria for likely positive, putatively positive, likely false and false preys, and tables showing the gene ontology terms associated with the likely and putative preys of the brain and bone marrow libraries...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27913591/temporal-expectations-guide-dynamic-prioritization-in-visual-working-memory-through-attenuated-alpha-oscillations
#3
Freek van Ede, Marcel Niklaus, Anna C Nobre
: While working memory is generally considered a highly dynamic mnemonic store, popular laboratory tasks employed to understand its psychological and neural mechanisms (such as change detection and continuous reproduction) often remain relatively "static", involving the retention of a set number of items throughout a shared delay interval. In the current study, we investigated visual working memory in a more dynamic setting, and assessed: 1) whether internally guided temporal expectations can dynamically and reversibly prioritize individual mnemonic items at specific times at which they are deemed most relevant and 2) the neural substrates that support such dynamic prioritization...
December 2, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27891688/possible-role-of-calcitonin-gene-related-peptide-in-trigeminal-modulation-of-glomerular-microcircuits-of-the-rodent-olfactory-bulb
#4
Federica Genovese, Hanke Gwendolyn Bauersachs, Ines Gräßer, Janina Kupke, Laila Magin, Philipp Daiber, Julika Nakajima, Frank Möhrlen, Karl Messlinger, Stephan Frings
Chemosensation in the mammalian nose comprises detection of odorants, irritants and pheromones. While the traditional view assigned one distinct sub-system to each stimulus type, recent research has produced a more complex picture. Odorants are not only detected by olfactory sensory neurons but also by the trigeminal system. Irritants, in turn, may have a distinct odor, and some pheromones are detected by the olfactory epithelium. Moreover, it is well established that irritants change odor perception and vice versa...
November 27, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27889959/fumaric-acid-esters-attenuate-secondary-degeneration-following-spinal-cord-injury
#5
Marika Cordaro, Giovanna Casili, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
Spinal cord injury (SCI) causes permanent changes in motor, sensory and autonomic functions. Unfortunately, there are not a stable cures and current treatments include surgical decompression, methylprednisolone and hemodynamic control that lead to modest function recovery. Fumaric acid esters (FAEs) were firstly used in the management of an immunological skin disorder, such as psoriasis. Because of their potent anti-inflammatory effects, they have been introduced in multiple sclerosis. Investigation shown not only anti-inflammatory, but also supposed neuroprotective mechanism of action...
November 27, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27889229/brown-propolis-attenuates-cerebral-ischemia-induced-oxidative-damage-via-affecting-antioxidant-enzyme-system-in-mice
#6
Gholamreza Bazmandegan, Mohammad Taher Boroushaki, Ali Shamsizadeh, Fatemeh Ayoobi, Elham Hakimizadeh, Mohammad Allahtavakoli
Oxidative stress plays a critical role in ischemic brain injury. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) are the enzymes underlying the endogenous antioxidant mechanisms affected by stroke and are considered as oxidative stress biomarkers. Brown propolis (BP) is a bioactive natural product with a set of biological activities that in turn may differ depending on the area from which the substance is originated. The aim of this study was to investigate the effect of water-extracted brown propolis (WEBPs), from two regions of Iran, against cerebral ischemia-induced oxidative injury in a mouse model of stroke...
November 23, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27882946/er-stress-inhibitor-attenuates-hearing-loss-and-hair-cell-death-in-cdh23-erl-erl-mutant-mice
#7
Juan Hu, Bo Li, Luke Apisa, Heping Yu, Shami Entenman, Min Xu, Ruben Stepanyan, Bo-Jhih Guan, Ulrich Müller, Maria Hatzoglou, Qing Yin Zheng
Hearing loss is one of the most common sensory impairments in humans. Mouse mutant models helped us to better understand the mechanisms of hearing loss. Recently, we have discovered that the erlong (erl) mutation of the cadherin23 (Cdh23) gene leads to hearing loss due to hair cell apoptosis. In this study, we aimed to reveal the molecular pathways upstream to apoptosis in hair cells to exploit more effective therapeutics than an anti-apoptosis strategy. Our results suggest that endoplasmic reticulum (ER) stress is the earliest molecular event leading to the apoptosis of hair cells and hearing loss in erl mice...
November 24, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27882782/lidocaine-5-medicated-plaster-for-localized-neuropathic-pain-in-thoracic-surgical-patients
#8
Ulderico Freo, Carlo Ori, Francesco Ambrosio
Context Neuropathic pain is a common and distressing symptom in surgical thoracic patients. When it consistently presents with measurable sensory changes in a circumscribed area, neuropathic pain can be diagnosed as a localized neuropathic pain (LNP). Objective The purpose of this study was to report the efficacy of lidocaine 5% medicated plaster (Lido5%P) in the treatment of LNP in surgical thoracic patients. Methods We retrospectively reviewed the records of sixteen, cancer and noncancer, thoracic patients treated with Lido5%P for LNP...
November 24, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27881785/attenuation-of-responses-to-self-generated-sounds-in-auditory-cortical-neurons
#9
Brian P Rummell, Jan L Klee, Torfi Sigurdsson
: Many of the sounds that we perceive are caused by our own actions, for example when speaking or moving, and must be distinguished from sounds caused by external events. Studies using macroscopic measurements of brain activity in human subjects have consistently shown that responses to self-generated sounds are attenuated in amplitude. However, the underlying manifestation of this phenomenon at the cellular level is not well understood. To address this, we recorded the activity of neurons in the auditory cortex of mice in response to sounds generated by their own behavior...
November 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27876655/dorsal-root-ganglion-stimulation-attenuates-the-bold-signal-response-to-noxious-sensory-input-in-specific-brain-regions-insights-into-a-possible-mechanism-for-analgesia
#10
Christopher P Pawela, Jeffery M Kramer, Quinn H Hogan
Targeted dorsal root ganglion (DRG) electrical stimulation (i.e. ganglionic field stimulation - GFS) is an emerging therapeutic approach to alleviate chronic pain. Here we describe blood oxygen-level dependent (BOLD) functional magnetic resonance imaging (fMRI) responses to noxious hind-limb stimulation in a rat model that replicates clinical GFS using an electrode implanted adjacent to the DRG. Acute noxious sensory stimulation in the absence of GFS caused robust BOLD fMRI response in brain regions previously associated with sensory and pain-related response, such as primary/secondary somatosensory cortex, retrosplenial granular cortex, thalamus, caudate putamen, nucleus accumbens, globus pallidus, and amygdala...
November 19, 2016: NeuroImage
https://www.readbyqxmd.com/read/27874832/postictal-behavioural-impairments-are-due-to-a-severe-prolonged-hypoperfusion-hypoxia-event-that-is-cox-2-dependent
#11
Jordan S Farrell, Ismael Gaxiola-Valdez, Marshal D Wolff, Laurence S David, Haruna I Dika, Bryce L Geeraert, X Rachel Wang, Shaily Singh, Simon C Spanswick, Jeff F Dunn, Michael C Antle, Paolo Federico, Gordon Campbell Teskey
Seizures are often followed by sensory, cognitive or motor impairments during the postictal phase that show striking similarity to transient hypoxic/ischemic attacks. Here we show that seizures result in a severe hypoxic attack confined to the postictal period. We measured brain oxygenation in localized areas from freely-moving rodents and discovered a severe hypoxic event (pO2<10mmHg) after the termination of seizures. This event lasted over an hour, is mediated by hypoperfusion, generalizes to people with epilepsy, and is attenuated by inhibiting cyclooxygenase-2 or L-type calcium channels...
November 22, 2016: ELife
https://www.readbyqxmd.com/read/27874088/g9a-participates-in-nerve-injury-induced-kcna2-downregulation-in-primary-sensory-neurons
#12
Lingli Liang, Xiyao Gu, Jian-Yuan Zhao, Shaogen Wu, Xuerong Miao, Jifang Xiao, Kai Mo, Jun Zhang, Brianna Marie Lutz, Alex Bekker, Yuan-Xiang Tao
Nerve injury-induced downregulation of voltage-gated potassium channel subunit Kcna2 in the dorsal root ganglion (DRG) is critical for DRG neuronal excitability and neuropathic pain genesis. However, how nerve injury causes this downregulation is still elusive. Euchromatic histone-lysine N-methyltransferase 2, also known as G9a, methylates histone H3 on lysine residue 9 to predominantly produce a dynamic histone dimethylation, resulting in condensed chromatin and gene transcriptional repression. We showed here that blocking nerve injury-induced increase in G9a rescued Kcna2 mRNA and protein expression in the axotomized DRG and attenuated the development of nerve injury-induced pain hypersensitivity...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27853620/forward-modelling-the-rubber-hand-illusion-of-ownership-modifies-motor-sensory-predictions-by-the-brain
#13
Laura Aymerich-Franch, Damien Petit, Abderrahmane Kheddar, Gowrishankar Ganesh
The question of how we attribute observed body parts as our own, and the consequences of this attribution on our sensory-motor processes, is fundamental to understand how our brain distinguishes between self and other. Previous studies have identified interactions between the illusion of ownership, and multi-sensory integration and cross-sensory predictions by the brain. Here we show that illusory ownership additionally modifies the motor-sensory predictions by the brain. In our preliminary experiments, we observed a new numbness illusion following the classical rubber-hand illusion (RHI); brushing only the rubber hand after induction of the RHI results in illusory numbness in one's real hand...
August 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27853576/fine-scale-analysis-of-an-assassin-bug-s-behaviour-predatory-strategies-to-bypass-the-sensory-systems-of-prey
#14
Fernando G Soley
Some predators sidestep environments that render them conspicuous to the sensory systems of prey. However, these challenging environments are unavoidable for certain predators. Stenolemus giraffa is an assassin bug that feeds on web-building spiders; the web is the environment in which this predator finds its prey, but it also forms part of its preys' sophisticated sensory apparatus, blurring the distinction between environment and sensory systems. Stenolemus giraffa needs to break threads in the web that obstruct its path to the spiders, and such vibrations can alert the spiders...
October 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27852964/spinal-astrocytic-activation-contributes-to-mechanical-allodynia-in-a-rat-model-of-cyclophosphamide-induced-cystitis
#15
Bolong Liu, Minzhi Su, ShaoJun Tang, Xiangfu Zhou, Hailun Zhan, Fei Yang, Wenbiao Li, Tengcheng Li, Juncong Xie
BACKGROUND: Previous studies have demonstrated that glial cells play an important role in the generation and maintenance of neuropathic pain. Activated glial cells produce numerous mediators such as proinflammatory cytokines that facilitate neuronal activity and synaptic plasticity. Similarly, bladder pain syndrome/interstitial cystitis shares many characteristics of neuropathic pain. However, related report on the involvement of spinal glia in bladder pain syndrome/interstitial cystitis-associated pathological pain and the underlying mechanisms are still lacking...
2016: Molecular Pain
https://www.readbyqxmd.com/read/27845440/odour-induced-analgesia-mediated-by-hypothalamic-orexin-neurons-in-mice
#16
Shogo Tashiro, Ran Yamaguchi, Sodemi Ishikawa, Takeshi Sakurai, Katsuko Kajiya, Yuichi Kanmura, Tomoyuki Kuwaki, Hideki Kashiwadani
Various folk remedies employ certain odorous compounds with analgesic effects. In fact, linalool, a monoterpene alcohol found in lavender extracts, has been found to attenuate pain responses via subcutaneous, intraperitoneal, intrathecal, and oral administration. However, the analgesic effects of odorous compounds mediated by olfaction have not been thoroughly examined. We performed behavioural pain tests under odourant vapour exposure in mice. Among six odourant molecules examined, linalool significantly increased the pain threshold and attenuated pain behaviours...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27821781/il-33-st2-signaling-excites-sensory-neurons-and-mediates-itch-response-in-a-mouse-model-of-poison-ivy-contact-allergy
#17
Boyi Liu, Yan Tai, Satyanarayana Achanta, Melanie M Kaelberer, Ana I Caceres, Xiaomei Shao, Jianqiao Fang, Sven-Eric Jordt
Poison ivy-induced allergic contact dermatitis (ACD) is the most common environmental allergic condition in the United States. Case numbers of poison ivy ACD are increasing due to growing biomass and geographical expansion of poison ivy and increasing content of the allergen, urushiol, likely attributable to rising atmospheric CO2 Severe and treatment-resistant itch is the major complaint of affected patients. However, because of limited clinical data and poorly characterized models, the pruritic mechanisms in poison ivy ACD remain unknown...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27821327/targeting-nitrative-stress-for-attenuating-cisplatin-induced-downregulation-of-cochlear-lim-domain-only-4-and-ototoxicity
#18
Samson Jamesdaniel, Rajamani Rathinam, William L Neumann
Cisplatin-induced ototoxicity remains a primary dose-limiting adverse effect of this highly effective anticancer drug. The clinical utility of cisplatin could be enhanced if the signaling pathways that regulate the toxic side-effects are delineated. In previous studies, we reported cisplatin-induced nitration of cochlear proteins and provided the first evidence for nitration and downregulation of cochlear LIM domain only 4 (LMO4) in cisplatin ototoxicity. Here, we extend these findings to define the critical role of nitrative stress in cisplatin-induced downregulation of LMO4 and its consequent ototoxic effects in UBOC1 cell cultures derived from sensory epithelial cells of the inner ear and in CBA/J mice...
December 2016: Redox Biology
https://www.readbyqxmd.com/read/27818209/the-role-of-brain-oscillations-in-predicting-self-generated-sounds
#19
Liyu Cao, Gregor Thut, Joachim Gross
Being able to predict self-generated sensory consequences is an important feature of normal brain functioning. In the auditory domain, self-generated sounds lead to smaller brain responses (e.g., auditory evoked responses) compared to externally generated sounds, which is usually referred to as the sensory attenuation effect. Here we investigated the role of brain oscillations underlying this effect. With magnetoencephalography, we show that self-generated sounds are associated with increased pre-stimulus alpha power and decreased post-stimulus gamma power and alpha/beta phase locking in auditory cortex...
November 3, 2016: NeuroImage
https://www.readbyqxmd.com/read/27816764/valence-and-arousal-value-of-visual-stimuli-and-their-role-in-the-mitigation-of-chronic-pain-what-is-the-power-of-pictures
#20
Maryam Shaygan, Andreas Böger, Birgit Kröner-Herwig
: The present study investigated the pain-reducing effects of various pictures in a sample of 88 patients receiving inpatient treatment for chronic pain. We investigated whether the pain attenuating effects of the pictures were mediated by picture valence, arousal or change in subjective social support. The study was carried out over four consecutive days. Patients were presented with photographs of loved ones, strangers, landscapes or optical illusions via digital albums and were asked to rate their pain intensity and their sensory and affective experience of pain immediately before and after viewing the pictures...
November 2, 2016: Journal of Pain: Official Journal of the American Pain Society
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