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https://www.readbyqxmd.com/read/28938322/the-relationship-of-the-temporal-branch-of-the-facial-nerve-to-the-fascial-planes-of-temporal-region-in-human-fetuses
#1
Özlem Elvan, Alev Bobuş Kara, Mesut Sabri Tezer, Mustafa Aktekin
The aim of this study was to obtain information by assessing the relationship between temporal region fascial structures, fat pads, and temporal branches of facial nerve in human fetuses to use the knowledge on treatment of early childhood period surgeries. This anatomic dissection study was conducted on 40 hemifaces with no visible external abnormalities on their faces. Fascial layers and related fat pads of temporal region were dissected layer by layer beginning from superficial to deep. The relations of temporal branches of facial nerve and temporoparietal fascia and the structures of these fascial layers were evaluated...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28937530/effects-of-magnesium-chloride-on-rocuronium-induced-neuromuscular-blockade-and-sugammadex-reversal-in-an-isolated-rat-phrenic-nerve-hemidiaphragm-preparation-an-in-vitro-study
#2
Tae-Yun Sung, Hwang-Ju You, Choon-Kyu Cho, Hey Ran Choi, Yong Beom Kim, Yong Sup Shin, Hong Seuk Yang
BACKGROUND: Magnesium potentiates the effects of nondepolarising muscle relaxants. However, few studies have used magnesium chloride (MgCl2). Sugammadex reverses neuromuscular block by steroidal nondepolarising muscle relaxants. OBJECTIVES: To assess the effects of MgCl2 on rocuronium-induced neuromuscular blockade and its reversal by sugammadex. DESIGN: In-vitro experimental study. SETTING: Animal laboratory, Asan Medical Center, Seoul, South Korea, from 20 March 2016 to 3 April 2016...
September 20, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28937496/characterizing-intraorbital-optic-nerve-changes-on-diffusion-tensor-imaging-in-thyroid-eye-disease-before-dysthyroid-optic-neuropathy
#3
Hwa Lee, Young Hen Lee, Sang-Il Suh, Eun-Kee Jeong, Sehyun Baek, Hyung Suk Seo
OBJECTIVE: The aim of this study was to determine whether the optic nerve is affected by thyroid eye disease (TED) before the development of dysthyroid optic neuropathy with diffusion-tensor imaging (DTI). METHODS: Twenty TED patients and 20 controls were included. The mean, axial, and radial diffusivities and fractional anisotropy (FA) value were measured at the optic nerves in DTI. Extraocular muscle diameters were measured on computed tomography. The diffusivities and FA of the optic nerves were compared between TED and controls and between active and inactive stages of TED...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28937031/a-novel-agrn-mutation-leads-to-congenital-myasthenic-syndrome-only-affecting-limb-girdle-muscle
#4
Ying Zhang, Yi Dai, Jing-Na Han, Zhao-Hui Chen, Li Ling, Chuan-Qiang Pu, Li-Ying Cui, Xu-Sheng Huang
BACKGROUND: Congenital myasthenic syndromes (CMSs) are a group of clinically and genetically heterogeneous disorders caused by impaired neuromuscular transmission. The defect of AGRN was one of the causes of CMS through influencing the development and maintenance of neuromuscular transmission. However, CMS reports about this gene mutation were rare. Here, we report a novel homozygous missense mutation (c.5302G>C) of AGRN in a Chinese CMS pedigree. METHODS: We performed a detailed clinical assessment of a Chinese family with three affected members...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28935526/characterization-of-calcium-transients-during-early-embryogenesis-in-the-ascidian-ciona-robusta-ciona-intestinalis-type-a-and-ciona-savignyi
#5
Taichi Akahoshi, Kohji Hotta, Kotaro Oka
The calcium ion (Ca(2+)) is an important second messenger, and a rapid increase in Ca(2+) level (Ca(2+) transient) is involved in various aspects of embryogenesis. Although Ca(2+) transients play an important role in early developmental stages, little is known about the dynamics of Ca(2+) transients throughout embryogenesis. Here, Ca(2+) transients were characterized by visualizing Ca(2+) dynamics in developing chordate embryos using a fluorescent protein-based Ca(2+) indicator, GCaMP6s in combination with finely tuned microscopy...
September 18, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28935232/utilising-physiological-principles-of-motor-unit-recruitment-to-reduce-fatigability-of-electrically-evoked-contractions-a-narrative-review
#6
Trevor S Barss, Emily N Ainsley, Francisca C Claveria-Gonzalez, M John Luu, Dylan J Miller, Matheus J Wiest, David F Collins
Neuromuscular electrical stimulation (NMES) is used to produce contractions to restore movement and reduce secondary complications for individuals experiencing motor impairment. NMES is conventionally delivered through a single pair of electrodes over a muscle belly or nerve trunk using short pulse durations and frequencies between 20-40 Hz (conventional NMES). Unfortunately, the benefits and widespread use of conventional NMES are limited by contraction fatigability, which is due in large part to the non-physiological way that contractions are generated...
September 18, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28935172/a-pediatric-case-with-peripheral-facial-nerve-palsy-caused-by-a-granulomatous-lesion-associated-with-cat-scratch-disease
#7
Chizuko Nakamura, Yuji Inaba, Keiko Tsukahara, Mie Mochizuki, Emi Sawanobori, Yozo Nakazawa, Kouki Aoyama
BACKGROUND: Cat scratch disease is a common infectious disorder caused by Bartonella henselae that is transmitted primarily by kittens. It typically exhibits a benign and self-limiting course of subacute regional lymphadenopathy and fever lasting two to eight weeks. The most severe complication of cat scratch disease is involvement of the nervous system, such as encephalitis, meningitis, and polyneuritis. Peripheral facial nerve palsy associated with Bartonella infection is rare; few reported pediatric and adult cases exist and the precise pathogenesis is unknown...
September 18, 2017: Brain & Development
https://www.readbyqxmd.com/read/28934803/two-interesting-cases-of-meralgia-paraesthetica
#8
Christopher David Jones, Luke Guiot, Mark Portelli, Timothy Bullen, Paul Skaife
Meralgia paraesthetica (MP) is a condition originally described by Bernhardt in 1878 and was eventually named by Roth in 1895. It is caused by compression of the lateral femoral cutaneous nerve (LFCN) resulting in varying types of discomfort. Severity of the symptoms can range from mildly uncomfortable to painfully disabling. In this article we discuss 2 patients with a LFCN injury occurring as a result of laparoscopic ventral rectopexy (LVR). The first patient is a 46-year-old female who reported pain and dysesthesia in the left groin and the anterolateral thigh, 2 days post LCR...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934388/loss-of-slc25a46-causes-neurodegeneration-by-affecting-mitochondrial-dynamics-and-energy-production-in-mice
#9
Zhuo Li, Yanyan Peng, Robert B Hufnagel, Yueh-Chiang Hu, Chuntao Zhao, Luis F Queme, Zaza Khuchua, Ashley M Driver, Fei Dong, Q Richard Lu, Diana M Lindquist, Michael P Jankowski, Rolf W Stottmann, Winston W Y Kao, Taosheng Huang
Recently, we identified biallelic mutations of SLC25A46 in patients with multiple neuropathies. Functional studies revealed that SLC25A46 may play an important role in mitochondrial dynamics by mediating mitochondrial fission. However, the cellular basis and pathogenic mechanism of the SLC25A46-related neuropathies are not fully understood. Thus, we generated a Slc25a46 knock-out mouse model. Mice lacking SLC25A46 displayed severe ataxia, mainly caused by degeneration of Purkinje cells. Increased numbers of small, unmyelinated and degenerated optic nerves as well as loss of retinal ganglion cells indicated optic atrophy...
October 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28933185/identification-and-distribution-of-the-interstitial-cells-of-cajal-in-the-abomasum-of-goats
#10
Lingling Wang, Yu Liang, Qiusheng Chen, Nisar Ahmed, Feng Wang, Bing Hu, Ping Yang
The interstitial cells of Cajal (ICCs) are regarded as pacemakers and are involved in neurotransmission in the gastrointestinal tract (GIT) of animals. However, limited information is available about the existence of ICCs within the GIT of ruminants. In this study, we investigated the ultrastructural characteristics and distribution of ICCs in goat abomasum using transmission electron microscopy and c-kit immunohistochemistry. Two different kinds of c-kit immunoreactive cells were observed in the abomasum. The first was identified as ICCs, which appeared to be multipolar or bipolar in shape, with some processes...
January 1, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28932609/neuromyelitis-optica-in-a-nepalese-man
#11
Yogesh Subedi, Utsav Joshi, Sanjeeb Sudarshan Bhandari, Ashbina Pokharel, Ashbita Pokharel
BACKGROUND: Neuromyelitis optica is a severely disabling inflammatory disorder of the central nervous system of autoimmune etiology that mainly affects the optic nerves and spinal cord. Here, we present a case report detailing a patient with tingling and weakness of right upper and lower limbs who was neuromyelitis optica immunoglobulin G-positive. CASE PRESENTATION: A 46-year-old Nepalese man presented to the hospital with a history of tingling and weakness of right upper and lower limbs that developed over a period of two months...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28932551/electro-physiological-evidence-of-intercostal-nerve-injury-after-thoracotomy-an-experimental-study-in-a-sheep-model
#12
Ruoyu Zhang, Kerstin Schwabe, Marcus Krüger, Axel Haverich, Joachim K Krauss, Mesbah Alam
BACKGROUND: Although intercostal nerve injury is one of the major causes for post-thoracotomy pain, the exact mechanisms are still unclear. We sought to evaluate the electro-physiological changes of intercostal nerve injury after thoracotomy in a sheep model. METHODS: Adult sheep underwent thoracotomy in the sixth intercostal space by employing diathermy to superior border of the seventh rib. In two sheep, ribs were then spread using retractor spreading for a distance of 7 cm for 30 minutes...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28931824/boosted-regeneration-and-reduced-denervated-muscle-atrophy-by-neuroheal-in-a-pre-clinical-model-of-lumbar-root-avulsion-with-delayed-reimplantation
#13
David Romeo-Guitart, Joaquim Forés, Xavier Navarro, Caty Casas
The "gold standard" treatment of patients with spinal root injuries consists of delayed surgical reconnection of nerves. The sooner, the better, but problems such as injury-induced motor neuronal death and muscle atrophy due to long-term denervation mean that normal movement is not restored. Herein we describe a preclinical model of root avulsion with delayed reimplantation of lumbar roots that was used to establish a new adjuvant pharmacological treatment. Chronic treatment (up to 6 months) with NeuroHeal, a new combination drug therapy identified using a systems biology approach, exerted long-lasting neuroprotection, reduced gliosis and matrix proteoglycan content, accelerated nerve regeneration by activating the AKT pathway, promoted the formation of functional neuromuscular junctions, and reduced denervation-induced muscular atrophy...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931549/sacral-neuromodulation-blocks-pudendal-inhibition-of-reflex-bladder-activity-in-cats-insight-into-the-efficacy-of-sacral-neuromodulation-in-fowler-s-syndrome
#14
Xing Li, Jamie Uy, Michelle Yu, Shun Li, Katherine Theisen, Jeffrey Browning, Bing Shen, Jicheng Wang, James R Roppolo, William C de Groat, Changfeng Tai
This study tested the hypothesis that sacral neuromodulation, i.e. electrical stimulation of afferent axons in sacral spinal root, can block pudendal afferent inhibition of the micturition reflex. In α-chloralose anesthetized cats, pudendal nerve stimulation (PNS) at 3-5 Hz was used to inhibit bladder reflex activity while the sacral S1 or S2 dorsal root was stimulated at 15-30 Hz to mimic sacral neuromodulation and to block the bladder inhibition induced by PNS. The intensity threshold (T) for PNS or S1/S2 dorsal root stimulation (DRS) to induce muscle twitch of anal sphincter or toe was determined...
September 20, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28931313/muscle-expression-of-sod1g93a-triggers-the-dismantlement-of-neuromuscular-junction-via-pkc-theta
#15
Gabriella Dobrowolny, Martina Martini, Bianca Maria Scicchitano, Vanina Romanello, Simona Boncompagni, Carmine Nicoletti, Laura Pietrangelo, Simone De Panfilis, Angela Catizone, Marina Bouche, Marco Sandri, Rudiger Rudolf, Feliciano Protasi, Antonio Musaro
Aim Neuromuscular junction (NMJ) represents the morpho-functional interface between muscle and nerve. Several chronic pathologies such as aging and neurodegenerative diseases, including muscular dystrophy and Amyotrophic Lateral Sclerosis (ALS), display altered NMJ and functional denervation. However, the triggers and the molecular mechanisms underlying the dismantlement of NMJ remain unclear. Results Here we provide evidence that perturbation in redox signaling cascades, induced by muscle-specific accumulation of mutant SOD1G93A in transgenic MLC/SOD1G93A mice, is causally linked to morphological alterations of the neuromuscular presynaptic terminals, high turnover rate of Acetylcholine Receptor (AChR), and NMJ dismantlement...
September 20, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28931253/relationship-of-the-optic-nerve-to-the-medial-rectus-muscle-during-endonasal-dissection-of-the-medial-intraconal-orbital-apex
#16
Dmitriy Petrov, John Craig, Jayesh Thawani, Kalil Abdullah, James N Palmer, Nithin D Adappa, John Y K Lee
BACKGROUND: Few studies have established surgical landmarks for endoscopic endonasal dissection of the intraconal orbital apex (OA). OBJECTIVE: We describe the optic nerve (ON) anatomy and its relationships, as seen during a fully endoscopic, endonasal approach to the medial intraconal OA. METHODS: The study question was approached through a cadaver dissection and a radiographic study. Four formalin-fixed, latex-injected cadaver heads were dissected using transnasal endoscopic techniques...
February 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28930862/an-innovative-ergometer-to-measure-neuromuscular-fatigue-immediately-after-cycling
#17
Douglas Doyle-Baker, John Temesi, Mary E Medysky, Robert J Holash, Guillaume Y Millet
PURPOSE: When assessing neuromuscular fatigue (NMF) from dynamic exercise using large muscle mass (e.g. cycling), most studies have delayed measurement for 1-3 min after task failure. This study aimed to determine the reliability of an innovative cycling ergometer permitting the start of fatigue measurement within 1 s after cycling. METHODS: Twelve subjects participated in two experimental sessions. Knee-extensor NMF was assessed by electrical nerve and transcranial magnetic stimulation with both a traditional chair set-up (PRE and POST-Chair, 2 min post-exercise) and the new cycling ergometer (PRE, every 3 min during incremental exercise and POST-Bike, at task failure)...
September 19, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28929274/minimally-invasive-posterior-cervical-foraminotomy-for-treatment-of-radiculopathy-an-effective-time-tested-and-cost-efficient-motion-preservation-technique
#18
REVIEW
L Papavero, R Kothe
OBJECTIVE: To relieve foraminal root impingement due to lateral soft disc fragments, bony spurs, or other rarer causes. INDICATIONS: Soft disc fragment whose bulk is >2/3 lateral to the lateral border of the thecal sac. Intraforaminal dorsal bony narrowing of the root canal. Intraforaminal synovial cyst, extra/intradural tumor. CONTRAINDICATIONS: Paramedian and median soft/hard disc protrusions. Kyphosis of the index level. SURGICAL TECHNIQUE: Patient prone in reverse Trendelenburg position with the head fixed in a Mayfield clamp...
September 19, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28927918/the-safety-of-irreversible-electroporation-on-nerves-adjacent-to-treated-tumors
#19
Xiaomei Luo, Zilin Qin, Huimin Tao, Jian Shi, Gang Fang, Zhonghai Li, Xulong Zhou, Jibing Chen, Kecheng Xu, Jianying Zeng, Lizhi Niu
OBJECTIVES: To evaluate the safety of irreversible electroporation (IRE) on the sciatic nerve after IRE ablation of adjacent tumor. METHODS: and analysis In this study, VX2 tumors were implanted adjacent to the sciatic nerves in 26 New Zealand white rabbits. The rabbits were divided into three groups 10 days after implantation, with two treatment groups of ten rabbits each and a control group of six rabbits. In one of the treatment groups (IRE-S group), the rabbits underwent ablation with a single IRE application, and in the other group (IRE-D group) the rabbits underwent two IRE applications...
September 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28924737/contribution-to-the-anatomical-nomenclature-concerning-lower-limb-anatomy
#20
David Kachlik, Vladimir Musil, Vaclav Baca
PURPOSE: The aim of this article is to extend and revise the sections of Terminologia Anatomica (TA) dealing with the lower limb structures and to justify the use of newly proposed anatomical terms in clinical medicine, education, and research. METHODS: Anatomical terms were gathered during our educational experience from anatomical textbooks and journals and compared with the four previous editions of the official Latin anatomical nomenclature. RESULTS: The authors summarise 270 terms with their definitions and explanations for both constant and variable morphological structures (bones, joints, muscles, vessels, nerves and superficial structures) of the hip, thigh, knee, leg, ankle, and foot completed with several grammatical remarks and some general anatomical terms...
September 18, 2017: Surgical and Radiologic Anatomy: SRA
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