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https://www.readbyqxmd.com/read/28813000/an-ameliorated-prediction-of-drug-target-interactions-based-on-multi-scale-discrete-wavelet-transform-and-network-features
#1
Cong Shen, Yijie Ding, Jijun Tang, Xinying Xu, Fei Guo
The prediction of drug-target interactions (DTIs) via computational technology plays a crucial role in reducing the experimental cost. A variety of state-of-the-art methods have been proposed to improve the accuracy of DTI predictions. In this paper, we propose a kind of drug-target interactions predictor adopting multi-scale discrete wavelet transform and network features (named as DAWN) in order to solve the DTIs prediction problem. We encode the drug molecule by a substructure fingerprint with a dictionary of substructure patterns...
August 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28812985/interventions-to-support-integrated-psychological-care-and-holistic-health-outcomes-in-paediatrics
#2
REVIEW
Roz Shafran, Sophie D Bennett, Mhairi McKenzie Smith
There are strong calls from many national and international bodies for there to be a 'holistic' and integrated approach to the understanding and management of psychological and physical health needs. Such holistic approaches are characterized by the treatment of the whole person, taking into account mental and social factors, rather than just the symptoms of a disease. Holistic approaches can impact on mental and physical health and are cost-effective. Several psychological interventions have demonstrated efficacy in improving holistic health outcomes, for example Cognitive Behaviour Therapy, Behavioural Therapies and Problem Solving Therapies...
August 16, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28812836/understanding-internal-accountability-in-nigeria-s-routine-immunization-system-perspectives-from-government-officials-at-the-national-state-and-local-levels
#3
Daniel J Erchick, Asha S George, Chukwunonso Umeh, Chizoba Wonodi
BACKGROUND: Routine immunization coverage in Nigeria has remained low, and studies have identified a lack of accountability as a barrier to high performance in the immunization system. Accountability lies at the heart of various health systems strengthening efforts recently launched in Nigeria, including those related to immunization. Our aim was to understand the views of health officials on the accountability challenges hindering immunization service delivery at various levels of government...
December 10, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812697/fish-pool-their-experience-to-solve-problems-collectively
#4
Mike M Webster, Andrew Whalen, Kevin N Laland
Access to information is a key advantage of grouping. Although experienced animals can lead others to solve problems, less is known about whether partially informed individuals can pool experiences to overcome challenges collectively. Here we provide evidence of such 'experience-pooling'. We presented shoals of sticklebacks (Gasterosteus aculeatus) with a two-stage foraging task requiring them to find and access hidden food. Individual fish were either inexperienced or had knowledge of just one of the stages...
April 18, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28811475/microsecond-pulse-i-v-approach-to-understanding-defects-in-high-mobility-bi-layer-oxide-semiconductor-transistor
#5
Hyunsuk Woo, Sanghun Jeon
The carrier transport and device instability of amorphous oxide semiconductor devices are influenced by defects that are exponentially distributed in energy, because of amorphous phase channels and front/back interfaces with a large number of sub-gap states. Thus, understanding defects and charge trapping in oxide semiconductor transistors is required for being core device element in reliable production lines. In this paper, we present the transient charging effect, the charge trapping mechanism, and the dynamic charge transport of high-mobility bilayer oxide semiconductor transistors...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811031/bayesian-approach-to-peak-deconvolution-and-library-search-for-high-resolution-gas-chromatography-mass-spectrometry
#6
A Barcaru, H G J Mol, M Tienstra, G Vivó-Truyols
A novel probabilistic Bayesian strategy is proposed to resolve highly coeluting peaks in high-resolution GC-MS (Orbitrap) data. Opposed to a deterministic approach, we propose to solve the problem probabilistically, using a complete pipeline. First, the retention time(s) for a (probabilistic) number of compounds for each mass channel are estimated. The statistical dependency between m/z channels was implied by including penalties in the model objective function. Second, Bayesian Information Criterion (BIC) is used as Occam's razor for the probabilistic assessment of the number of components...
August 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28811006/improved-fat-transplantation-survival-by-using-the-conditioned-medium-of-vascular-endothelial-growth-factor-transfected-human-adipose-derived-stem-cells
#7
Yang Zhang, Li-Ling Xiao, Jiang-Xuan Li, Hong-Wei Liu, Sheng-Hong Li, Yan-Yun Wu, Xuan Liao, Cong-Qiang Rao
Autologous fat transplantation has been applied widely in clinic. However, the low survival rate is still a problem to be solved. Studies shows that the human adipose-derived stem cells (ADSCs) transfected by vascular endothelial growth factor (VEGF) can improve the survival rate of autologous fat transplantation. Our study is to evaluate the effects of the conditioned medium of VEGF-transfected human adipose-derived stem cells (VEGF-ADSCs-CM) on fat transplantation. ADSCs were isolated and transfected with MOI = 40...
August 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28810751/communication-on-the-diffusion-tensor-in-macroscopic-theory-of-cavitation
#8
Vitaly A Shneidman
The classical description of nucleation of cavities in a stretched fluid relies on a one-dimensional Fokker-Planck equation (FPE) in the space of their sizes r, with the diffusion coefficient D(r) constructed for all r from macroscopic hydrodynamics and thermodynamics, as shown by Zeldovich. When additional variables (e.g., vapor pressure) are required to describe the state of a bubble, a similar approach to construct a diffusion tensor D^ generally works only in the direct vicinity of the thermodynamic saddle point corresponding to the critical nucleus...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810125/cheminformatic-analysis-of-anti-malarial-chemical-space-illuminates-therapeutic-mechanisms-and-offers-strategies-for-therapy-development
#9
Julia Nogueira Varela, María Fernanda Fernanda Lammoglia Cobo, Sandip V Pawar, Vikramaditya G Yadav
The clear and present danger of malaria, which has been amplified in recent years by climate change, and the progressive thinning of our drug arsenal over the past two decades raise uncomfortable questions about the current state and future of anti-malarial drug development. Besides suffering from many of the same technical challenges that affect drug development in other disease areas, the quest for new anti-malarial therapies is also hindered by the complex, dynamic life cycle of the malaria parasite, P. falciparum, in its mosquito and human hosts, and its role thereof in the elicitation of drug resistance...
August 15, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28809983/controllable-synthesis-of-inorganic-organic-zn1-xcdxs-deta-solid-solution-nanoflowers-and-their-enhanced-visible-light-photocatalytic-hydrogen-production-performance
#10
Jiali Lv, Jinfeng Zhang, Kai Dai, Changhao Liang, Guangping Zhu, Zhongliao Wang, Zhen Li
Sustainable photocatalytic hydrogen evolution (PHE) of water splitting has been utilized to solve the serious environmental pollution and energy shortage problems over the last decade. Inorganic-organic hybrid materials could combine the organic molecules and functional inorganic blocks into unique materials through complicated physical and chemical interactions. In this paper, diethylenetriamine (DETA) was used as an organic molecule template for the synthesis of inorganic-organic Zn1-xCdxS-DETA solid solution nanoflowers (NFs) at very low temperature...
August 15, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28809685/human-motion-segmentation-via-robust-kernel-sparse-subspace-clustering
#11
Guiyu Xia, Huaijiang Sun, Lei Feng, Guoqing Zhang, Yazhou Liu
Studies on human motion have attracted a lot of attentions. Human motion capture data, which much more precisely records human motion than videos do, has been widely used in many areas. Motion segmentation is an indispensable step for many related applications, but current segmentation methods for motion capture data do not effectively model some important characteristics of motion capture data, such as Riemannian manifold structure and containing non-Gaussian noise. In this paper, we convert the segmentation of motion capture data into a temporal subspace clustering problem...
August 10, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28809683/low-rank-latent-pattern-approximation-with-applications-to-robust-image-classification
#12
Shuo Chen, Jian Yang, Lei Luo, Yang Wei, Kaihua Zhang, Ying Tai
This paper develops a novel method to address the structural noise in samples for image classification. Recently, regression related classification methods have shown promising results when facing the pixel-wise noise. However, they become weak in coping with the structural noise due to ignoring of relationships between pixels of noise image. Meanwhile, most of them need to implement the iterative process for computing representation coefficients, which leads to the high time consumption. To overcome these problems, we exploit a latent pattern model called Low-Rank Latent Pattern Approximation (LLPA) to reconstruct the test image having structural noise...
August 10, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28809676/simultaneous-clustering-and-model-selection-algorithm-theory-and-applications
#13
Zhuwen Li, Loong-Fah Cheong, Shuoguang Yang, Kim-Chuan Toh
While clustering has been well studied in the past decade, model selection has drawn much less attention due to the difficulty of the problem. In this paper, we address both problems in a joint manner by recovering an ideal affinity tensor from an imperfect input. By taking into account the relationship of the affinities induced by the cluster structures, we are able to significantly improve the affinity input, such as repairing those entries corrupted by gross outliers. More importantly, the recovered ideal affinity tensor also directly indicates the number of clusters and their membership, thus solving the model selection and clustering jointly...
August 14, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28809594/evaluating-health-service-quality-using-importance-performance-analysis
#14
Azar Izadi, Younes Jahani, Sima Rafiei, Ali Masoud, Leila Vali
Purpose Measuring healthcare service quality provides an objective guide for managers and policy makers to improve their services and patient satisfaction. Consequently, the purpose of this paper is to measure service quality provided to surgical and medical inpatients at Kerman Medical Sciences University (KUMS) in 2015. Design/methodology/approach A descriptive-analytic study, using a cross-sectional method in the KUMS training hospitals, was implemented between October 2 and March 15, 2015. Using stratified random sampling, 268 patients were selected...
August 14, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28808667/process-information-and-evolution
#15
Erick Chastain, Cameron Smith
Universal Semantic Communication (USC) is a theory that models communication among agents without the assumption of a fixed protocol. We demonstrate a connection, via a concept we refer to as process information, between a special case of USC and evolutionary processes. In this context, one agent attempts to interpret a potentially arbitrary signal produced within its environment. Sources of this effective signal can be modeled as a single alternative agent. Given a set of common underlying concepts that may be symbolized differently by different sources in the environment, any given entity must be able to correlate intrinsic information with input it receives from the environment in order to accurately interpret the ambient signal and ultimately coordinate its own actions...
December 2016: IEEE Trans Mol Biol Multiscale Commun
https://www.readbyqxmd.com/read/28808442/firefly-mating-algorithm-for-continuous-optimization-problems
#16
Amarita Ritthipakdee, Arit Thammano, Nol Premasathian, Duangjai Jitkongchuen
This paper proposes a swarm intelligence algorithm, called firefly mating algorithm (FMA), for solving continuous optimization problems. FMA uses genetic algorithm as the core of the algorithm. The main feature of the algorithm is a novel mating pair selection method which is inspired by the following 2 mating behaviors of fireflies in nature: (i) the mutual attraction between males and females causes them to mate and (ii) fireflies of both sexes are of the multiple-mating type, mating with multiple opposite sex partners...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28807641/a-novel-partnership-disrupts-the-norm-in-early-childhood-education-and-pediatric-health-care
#17
EDITORIAL
M Denise Dowd, John D Lantos
Children living in poverty in the United States in 2016 face a devastating combination of psychological problems. Their neighborhoods are often violent. They have no place to get healthy food. It is not safe to play outside, even on playgrounds. The children who grow up in this environment, not surprisingly, have many adverse childhood experiences (ACEs). ACEs cause toxic stress. Toxic stress leads to long-term physical and psychological problems. For many pediatricians, children's hospitals, civic leaders, and public health officials, it is difficult to know how to intervene...
August 11, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28806714/f-norm-distance-metric-based-robust-2dpca-and-face-recognition
#18
Tao Li, Mengyuan Li, Quanxue Gao, Deyan Xie
Two-dimensional principal component analysis (2DPCA) employs squared F-norm as the distance metric for dimensionality reduction. It is commonly known that squared F-norm is sensitive to the presence of outliers. To address this problem, we use F-norm instead of squared F-norm as the distance metric in the objective function and develop a non-greedy algorithm, which has a closed-form solution in each iteration and can maximize the criterion function, to solve the optimal solution. Our approach not only is robust to outliers but also well characterizes the geometric structure of data...
July 21, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28806708/predictive-simulation-of-diabetic-gait-individual-contribution-of-ankle-stiffness-and-muscle-weakening
#19
Gilmar F Santos, Aline A Gomes, Isabel C N Sacco, Marko Ackermann
Diabetic neuropathic individuals present massive muscle strength reduction at the ankle plantar- and dorsiflexors and increased joint stiffness. Our aim is to investigate the adaptation strategies to these musculoskeletal alterations during walking by means of predictive simulations. We used a seven segment planar musculoskeletal model actuated by eight Hill-type muscles in each leg. The effect of all passive tissue in muscles and other joint structures was modeled by net passive joint moment curves. The predictive simulations were generated by solving an optimal control problem that minimized a cost function, including effort and tracking terms, using direct collocation and a commercial optimal control package...
August 1, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28806606/imbalance-between-abstract-and-concrete-repetitive-thinking-modes-in-schizophrenia
#20
Pierre Maurage, Pierre Philippot, Delphine Grynberg, Dominique Leleux, Benoît Delatte, Camille Mangelinckx, Jan-Baptist Belge, Eric Constant
OBJECTIVE: Repetitive thoughts can be divided in two modes: abstract/analytic (decontextualized and dysfunctional) and concrete/experiential (problem-focused and adaptive). They constitute a transdiagnostic process involved in many psychopathological states but have received little attention in schizophrenia, as earlier studies only indexed increased ruminations (related to dysfunctional repetitive thoughts) without jointly exploring both modes. This study explored the two repetitive thinking modes, beyond ruminations, to determine their imbalance in schizophrenia...
July 1, 2017: Comprehensive Psychiatry
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