keyword
MENU ▼
Read by QxMD icon Read
search

HPA

keyword
https://www.readbyqxmd.com/read/27908897/cortisol-as-a-predictor-of-psychological-therapy-response-in-depressive-disorders-systematic-review-and-meta-analysis
#1
REVIEW
Susanne Fischer, Rebecca Strawbridge, Andres Herane Vives, Anthony J Cleare
BACKGROUND: Many patients with depressive disorders demonstrate resistance to psychological therapy. A frequent finding is hypothalamic-pituitary-adrenal (HPA) axis alterations. As cortisol is known to modulate cognitive processes, those patients may be less likely to profit from psychological therapy. AIMS: To conduct a systematic review and meta-analysis on cortisol as a predictor of psychological therapy response. METHOD: The Cochrane Library, EMBASE, MEDLINE and PsycINFO databases were searched...
December 1, 2016: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/27908847/homeostasis-of-the-gut-barrier-and-potential-biomarkers
#2
Jerry M Wells, Robert J Brummer, Muriel Derrien, Thomas T MacDonald, Freddy Troost, Patrice D Cani, Vassilia Theodorou, Jan Dekker, Agnes Méheust, Willem M de Vos, Annick Mercenier, Arjen Nauta, Clara L Garcia-Rodenas
The gut barrier plays a crucial role by spatially compartmentalizing bacteria to the lumen through the production of secreted mucus and is fortified by the production of sIgA and antimicrobial peptides and proteins. With exception of sIgA the expression of these protective barrier factors is largely controlled by innate immune recognition of microbial molecular ligands. Several specialized adaptations and checkpoints are operating in the mucosa to scale the immune response according to the threat and prevent overreaction to the trillions of symbionts inhabiting the human intestine...
December 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27908768/acute-stress-diminishes-m-current-contributing-to-elevated-activity-of-hypothalamic-pituitary-adrenal-axis
#3
Jing-Jing Zhou, Yonggang Gao, Therese A Kosten, Zongmao Zhao, De-Pei Li
Acute stress stimulates corticotrophin-releasing hormone (CRH)-expressing neurons in the hypothalamic paraventricular nucleus (PVN), which is an essential component of hypothalamic-pituitary-adrenal (HPA) axis. However, the cellular and molecular mechanisms remain unclear. The M-channel is a voltage-dependent K(+) channel involved in stabilizing the neuronal membrane potential and regulating neuronal excitability. In this study, we tested our hypothesis that acute stress suppresses expression of Kv7 channels to stimulate PVN-CRH neurons and the HPA axis...
November 28, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27907849/association-between-dehydroepiandrosterone-sulfate-and-attention-in-long-term-survivors-of-childhood-acute-lymphoblastic-leukemia-treated-with-only-chemotherapy
#4
Yin Ting Cheung, Wassim Chemaitilly, Daniel A Mulrooney, Tara M Brinkman, Wei Liu, Pia Banerjee, Deokumar Srivastava, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Kevin R Krull
Long-term survivors of childhood acute lymphoblastic leukemia (ALL) are at risk for neurocognitive impairment, as well as compromised hypothalamic-pituitary-adrenal (HPA) function. Dehydroepiandrosterone-sulfate (DHEAS) is an adrenal androgen commonly used as a marker of HPA function. In the general population, a low level of DHEAS has been associated with poorer cognition. At ≥2years post-treatment, we examined the association of DHEAS with attention outcomes in 35 male and 34 female long-term survivors of childhood ALL (mean[standard deviation] age at evaluation 14...
November 16, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27904111/restoration-of-the-hypothalamic-pituitary-adrenal-response-to-hypoglycemia-in-type-2-diabetes-by-avoiding-chronic-hypoglycemia
#5
Shin-Ichi Tsuda, Kazunori Konishi, Toshiki Otoda, Takako Nagai, Ai Takeda-Watanabe, Megumi Kanasaki, Munehiro Kitada, Atsushi Nakagawa, Makoto Nishizawa, Keizo Kanasaki, Daisuke Koya
An impaired ability to sense and respond to drug-induced hypoglycemia is a common and serious complication in diabetic patients. The hypothalamic-pituitary-adrenal (HPA) axis activity plays a critical role in the counterregulatory response to hypoglycemia. We herein report a case that experienced restoration of a blunted HPA axis by avoiding hypoglycemia with the use of the DPP-4 inhibitor sitagliptin.
2016: Internal Medicine
https://www.readbyqxmd.com/read/27898075/maternal-high-fat-diet-prevents-developmental-programming-by-early-life-stress
#6
M Rincel, A L Lépinay, P Delage, J Fioramonti, V S Théodorou, S Layé, M Darnaudéry
Anxiety disorders and depression are well-documented in subjects exposed to adverse childhood events. Recently, maternal obesity and/or maternal consumption of high-fat diets (HFD) have been also proposed as risk factors for offspring mental health. Here using an animal model in rats, we explored the combinatorial effects of a maternal HFD (40% of energy from fat without impact on maternal weight; during gestation and lactation) and maternal separation (MS) in offspring. In the prefrontal cortex (PFC) of pups, MS led to changes in the expression of several genes such as Bdnf (brain derived neurotrophic factor), 5HT-r1a (serotonin receptor 1a) and Rest4 (neuron-restrictive silencer element, repressor element 1, silencing transcription factor (Rest), splicing variant 4)...
November 29, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27894002/polymorphism-in-crhr1-gene-affects-the-il-1%C3%AE-levels-in-suicidal-attempters
#7
Clarissa R Bastos, Marta Gazal, Luciana de A Quevedo, Joice Luisa Costa, Carolina D Wiener, Karen Jansen, Christian Loret de Mola, Jean P Oses, Luciano D M Souza, Luiz Valmor Portela, Ricardo T Pinheiro, Ricardo A da Silva, Diogo R Lara, Gabriele Ghisleni
Approximately one million people commit suicide every year, being suicide attempts and ideation even more common. Changes in stress response and activation of the immune system have been associated with suicide risk. Here we investigated the interaction between immune system and HPA axis alterations in the suicide risk, looking for the influence of rs110402 CRHR1 SNP in the IL-1β levels according to suicide ideation and attempt. This study evaluated 171 subjects of which 15 had suicidal ideation, 20 had suicide attempt and 136 were controls...
November 18, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27893788/effects-of-high-fat-diet-on-stress-response-in-male-and-female-wildtype-and-prolactin-knockout-mice
#8
Manu Kalyani, Kathryn Hasselfeld, James M Janik, Phyllis Callahan, Haifei Shi
Prolactin (PRL) is well characterized for its roles in initiation and maintenance of lactation, and it also suppresses stress-induced responses. Feeding a high-fat diet (HFD) disrupts activity of the hypothalamic-pituitary-adrenal (HPA) axis. Whether PRL regulates HPA axis activation under HFD feeding is not clear. Male and female wildtype (WT) and PRL knockout (KO) mice were fed either a standard low-fat diet (LFD) or HFD for 12 weeks. Circulating corticosterone (CORT) levels were measured before, during, and after mice were subjected to an acute restraint stress or remained in their home cages as no stress controls...
2016: PloS One
https://www.readbyqxmd.com/read/27893234/mindful-parenting-predicts-mothers-and-infants-hypothalamic-pituitary-adrenal-activity-during-a-dyadic-stressor
#9
Heidemarie K Laurent, Larissa G Duncan, April Lightcap, Faaiza Khan
Mindfulness in the parenting relationship has been proposed to help both parents and children better regulate stress, though this has not yet been shown at the physiological level. In this study, we tested relations between maternal mindfulness in parenting and both mothers' and their infants' hypothalamic-pituitary-adrenal (HPA) axis activity during a dyadic stressor 3 months later. Participants were 73 mother-infant dyads from a larger longitudinal study. At 3 months postpartum, mothers completed self-report measures of general dispositional mindfulness and parenting-specific mindfulness, as well as stressful life events...
November 28, 2016: Developmental Psychology
https://www.readbyqxmd.com/read/27889466/lower-cortisol-level-in-response-to-a-psychosocial-stressor-in-young-females-with-self-harm
#10
Paul L Plener, Katrin Zohsel, Erika Hohm, Arlette F Buchmann, T Banaschewski, Ulrich S Zimmermann, Manfred Laucht
BACKGROUND: Self-harm is highly prevalent in adolescence, often serving an emotion regulation function. Social stressors such as bullying are associated with self-harm. The neurobiological background of the relationship between social stressors and self-harm needs to be further understood to inform prevention and therapy. METHODS: Participants were members of an epidemiological cohort study. 130 female participants underwent the Trier Social Stress Test (TSST) at age 19...
November 14, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27888772/adrenocortical-sensitivity-moderated-by-ongoing-stress-predicts-drinking-intensity-in-alcohol-dependent-men
#11
Bryon Adinoff, David Leonard, Julianne Price, Martin A Javors, Robrina Walker, E Sherwood Brown, Hong Xiao, Uma Rao
Allostatic load from both environmental stressors and persistent glucocorticoid secretion has been associated with disease severity in alcohol dependence. Heightened relapse risk and/or drinking severity, in particular, may be a reaction to alcohol- and withdrawal-induced changes in physiological stress response systems coupled with ongoing life stress, although their shared contributions upon drinking severity have not been assessed. To investigate the combined contribution of hypothalamic-pituitary-adrenal (HPA) reactivity and environmental stressors (e...
November 5, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27888771/increased-anxiety-like-behaviors-but-blunted-cortisol-stress-response-after-neonatal-hippocampal-lesions-in-monkeys
#12
Jessica Raper, Mark Wilson, Mar Sanchez, Christa Payne, Jocelyne Bachevalier
The hippocampus is most notably known for its role in cognition and spatial memory; however it also plays an essential role in emotional behaviors and neuroendocrine responses. The current study investigated the long-term effects of neonatal hippocampal lesions (Neo-Hibo) on emotional and hypothalamic-pituitary-adrenal (HPA) axis functioning. During infancy, unlike controls, Neo-Hibo monkeys exhibited enhanced expression of emotional behaviors (e.g. freezing, anxiety-like, and self-directed behaviors) when exposed to a human intruder (HI task)...
November 18, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27887997/a-role-for-leptin-regulated-neurocircuitry-in-subordination-stress
#13
REVIEW
Jonathan N Flak
The visible burrow system produces a distinct combination of psychological and metabolic stress on, primarily, subordinate individuals that results in pronounced physiologic and behavioral dysfunction. However, the mechanisms underlying the consequences of chronic subordination stress are largely unknown. The simplest mechanistic explanation is that adaptations within brain systems with overlapping functions of both psychological and metabolic control provide immediate benefits that result in lasting susceptibility to diseases, disorders, and increased mortality rates in subordinates...
November 22, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27886719/a-dual-stage-adaptive-thresholding-dusat-for-automatic-mass-detection-in-mammograms
#14
J Anitha, J Dinesh Peter, S Immanuel Alex Pandian
BACKGROUND AND OBJECTIVE: Early detection and diagnosis of breast cancer through mammography screening reduces breast cancer mortality by around 20%. However it is often a complex process to differentiate abnormalities due to the ill-defined margins and subtle appearances. METHOD: This paper investigates a new computer aided approach to detect the abnormalities in the digital mammograms using a Dual Stage Adaptive Thresholding (DuSAT). The suspicious mass region is identified using global histogram and local window thresholding method...
January 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/27886020/cranial-electrotherapy-stimulation-affects-mood-state-but-not-levels-of-peripheral-neurotrophic-factors-or-hypothalamic-pituitary-adrenal-axis-regulation
#15
Hee-Tae Roh, Wi-Young So
Cranial electrotherapy stimulation (CES) is reported to aid in relieving symptoms of depression and anxiety, though the mechanism underlying this effect remains unclear. Therefore, the present study aimed to evaluate changes in the hypothalamic-pituitary-adrenal (HPA) axis response and levels of neurotrophic factors, as well as changes in mood state, in patients undergoing CES therapy. Fifty healthy postmenopausal women were randomly assigned to either a Sham CES group (n = 25) or an Active CES group (n = 25)...
November 18, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/27883964/sex-specific-association-between-functional-neuropeptide-s-receptor-gene-npsr1-variants-and-cortisol-and-central-stress-responses
#16
Fabian Streit, Ceren Akdeniz, Leila Haddad, Robert Kumsta, Sonja Entringer, Josef Frank, Ilona S Yim, Sandra Zänkert, Stephanie H Witt, Peter Kirsch, Marcella Rietschel, Stefan Wüst
The brain neuropeptide S (NPS) system has recently generated substantial interest and may be of major relevance for central stress regulation. The NPS receptor (NPSR1) is highly expressed in the limbic system, exogenous NPS exerts pronounced anxiolytic and fear-attenuating effects in rodents and extensive close crosstalk between the NPS system and the hypothalamic-pituitary-adrenal (HPA) axis has been demonstrated. In humans, associations between NPSR1 variants and anxiety and panic disorder, as well as amygdala responsiveness to fear- relevant faces and prefrontal cortex activity in a fear conditioning paradigm have been reported...
November 10, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27883963/hypothalamic-pituitary-adrenal-axis-activity-and-cognition-in-major-depression-the-role-of-remission-status
#17
Neus Salvat-Pujol, Javier Labad, Mikel Urretavizcaya, Aida de Arriba-Arnau, Cinto Segalàs, Eva Real, Alex Ferrer, José M Crespo, Susana Jiménez-Murcia, Carles Soriano-Mas, José M Menchón, Virginia Soria
OBJECTIVES: Neuropsychological deficits and hypothalamic-pituitary-adrenal (HPA) axis dysfunction have been described in major depressive disorder (MDD). We conducted an exploratory study to investigate the role of remission status in the relationship between HPA axis and cognition in MDD. METHODS: Ninety-seven MDD patients (44 remitted, 53 non-remitted) and 97 healthy controls (HC) were evaluated. We measured verbal and visual memory, working memory, processing speed, attention, and executive function...
November 10, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27882754/-fetal-alloimmune-thrombocytopenia-in-pregnant-woman-with-anti-hpa-1a-antibodies
#18
K Sobíšková, J Matěcha
OBJECT: Description of the pregnancy in patient with anti-HPA-1a antibodies. DESIGN: Case report. SETTING: Department of Obstetrics and Gynaecology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital. CASE REPORT: Report of cases of neonatal alloimune thrombocytopenia in a patient with proven anti-HPA 1a antibodies. The immunization developed during the first pregnancy, accompanied with fetal thrombocytopenia which recurred in every subsequent pregnancy with greater severity...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27879022/catalytic-janus-nanosheets-based-emulsion-for-ultra-deep-desulfurization
#19
Lixin Xia, Hairan Zhang, Zhichao Wei, Yi Jiang, Ling Zhang, Jie Zhao, Junhui Zhang, Li Dong, Erni Li, Laurent Ruhlmann, Qian Zhang
Catalytic Janus nanosheets were synthesized using an anion-exchange reaction between heteropolyacids (HPAs) and the modified ionic liquids (ILs) moieties of Janus nanosheets. Their morphologies and surface properties were characterized using SEM, EDS, FTIR and XPS spectra. Because of their inherent Janus structure, the nanosheets exhibited good amphipathic character with ILs and oil to form a stable ILs-in-oil emulsion. Therefore, such Janus nanosheets can be utilized both as emulsifiers and catalysts to perform emulsive desulfurization...
November 23, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27876634/individual-and-interactive-sex-specific-effects-of-acute-restraint-and-systemic-ifn-%C3%AE-treatment-on-neurochemistry
#20
Darcy Litteljohn, Chris Rudyk, Sara Razmjou, Zach Dwyer, Shuaib Syed, Shawn Hayley
Compelling evidence supports the involvement of the pro-inflammatory cytokines, IL-6, IFN-α and TNF-α in depression and related stress-associated pathologies. A role has also been suggested for the Th1-type cytokine, IFN-γ, with most mechanistic accounts focusing on the cytokine's capacity to induce indoleamine 2,3-dioxygenase (IDO), leading to diminished tryptophan and the generation of kynurenine metabolites. Beyond these IDO-dependent routes, there is surprisingly little evidence directly linking IFN-γ to alterations of brain regional monoamine activity and HPA axis functioning...
November 19, 2016: Neurochemistry International
keyword
keyword
39163
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"