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Acid base disturbance

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https://www.readbyqxmd.com/read/29664498/-hypophosphatemia-in-preterm-infants-a-bimodal-disorder
#1
María Paz Cubillos Celis, Patricia Mena Nannig
New nutritional approaches to treat extreme premature babies have demonstrated relevant eviden ce of metabolic disturbances with early hypophosphatemia, especially in patients with intrauterine growth restriction (IUGR). They have shown late hypophosphatemia, as well, which is characteristic in the metabolic bone disease. A sytematic search of literature describing metabolic disturbances of phosphorus in preterm newborns is presented, related to the use of early parenteral nutrition and also in the context of metabolic bone disease...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29652551/n-3-fatty-acid-supplementation-for-the-treatment-of-dry-eye-disease
#2
(no author information available yet)
Background Dry eye disease is a common chronic condition that is characterized by ocular discomfort and visual disturbances that decrease quality of life. Many clinicians recommend the use of supplements of n-3 fatty acids (often called omega-3 fatty acids) to relieve symptoms. Methods In a multicenter, double-blind clinical trial, we randomly assigned patients with moderate-to-severe dry eye disease to receive a daily oral dose of 3000 mg of fish-derived n-3 eicosapentaenoic and docosahexaenoic acids (active supplement group) or an olive oil placebo (placebo group)...
April 13, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29651844/a-novel-strategy-for-comprehensive-identification-of-acylcarnitines-based-on-liquid-chromatography-high-resolution-mass-spectrometry
#3
Di Yu, Lina Zhou, Qiuhui Xuan, Lichao Wang, Xinjie Zhao, Xin Lu, Guowang Xu
Carnitines play important roles in fatty acid oxidation and branched chain amino acid metabolism. The disturbance of acylcarnitines is associated with occurrence and development of many diseases. Comprehensive acylcarnitine identification can greatly benefit their targeted detection, following disease differential diagnosis and possible mechanism study. In this study, we developed a novel strategy to identify as many acylcarnitines as possible based on liquid chromatography-high resolution mass spectrometry (LC-HRMS)...
April 13, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29650854/-a-case-of-hyperammonemia-induced-by-chemotherapy-with-5-fluorouracil-for-metastatic-colon-cancer
#4
Shinji Tokuyama, Mutsumi Fukunaga, Ken Konishi, Shoko Honda, Ryohei Yukimoto, Aoi Okamoto, Akina Saito, Kazuyuki Okada, Hideo Ota, Shigekazu Yokoyama, Hirofumi Miki, Kenji Kobayashi
Systemic chemotherapy based on 5-fluorouracil(5-FU)is a standard treatment for unresectable or recurrent colon cancers. Here, we report a case of hyperammonemia induced by chemotherapy using 5-FU for metastatic colon cancer. An 84-yearold male patient with past histories of liver cirrhosis related to hepatitis C virus and renal dysfunction underwent an operation for the rectosigmoid colon cancer 8 years ago. Three years after that operation, a local recurrence of the colon cancer was diagnosed, and chemotherapy using sLV5FU2 was initiated...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29649820/accuracy-of-acid-base-diagnoses-using-the-central-venous-blood-gas-in-the-medical-intensive-care-unit
#5
Sarah J Schrauben, Dan Negoianu, Cristiana Costa, Raphael M Cohen, Stanley Goldfarb, Barry D Fuchs, Jeffrey S Berns
BACKGROUND: Acid-base disturbances are frequent in critically ill patients. Arterial blood gas (ABG) is the gold standard in the diagnosis of these disturbances, but it is invasive with potential hazards. For patients with a central venous catheter, venous blood gas (VBG) sampling may be an alternative, less-invasive diagnostic tool. However, the accuracy of a central VBG-based acid-base disorder diagnosis compared to an ABG is unknown. The primary objective of this study was to assess the accuracy of a central VBG-based acid-base disorder diagnosis compared to the "gold standard" ABG in critically ill patients...
April 12, 2018: Nephron
https://www.readbyqxmd.com/read/29625260/protective-effects-of-polygonum-multiflorum-on-ischemic-stroke-rat-model-analysed-by-1-h-nmr-metabolic-profiling
#6
Ming-Hui Li, Ling-Yu Ruan, Cheng Chen, Yue-Xiao Xing, Wei Hong, Rong-Hui Du, Jun-Song Wang
Stroke is the third most common cause of death in most industrialized countries. Polygonum multiflorum (He-Shou-Wu, HSW) is one of the traditional Chinese medicines with multiple pharmacological activities which is widely used in Chinese recipe. This study aims to explore the protective effect of HSW on ischemic stroke rat model and to elucidate the underlying mechanisms. The mortality rate, neurological deficit, cerebral infarct size, histopathology, immunohistochemistry, biochemical parameters, quantitative real-time polymerase chain reaction and western blotting were used to access the treatment effects of HSW on ischemic stroke...
March 31, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29615864/molecular-neuropathology-of-astrocytes-and-oligodendrocytes-in-alcohol-use-disorders
#7
REVIEW
José J Miguel-Hidalgo
Postmortem studies reveal structural and molecular alterations of astrocytes and oligodendrocytes in both the gray and white matter (GM and WM) of the prefrontal cortex (PFC) in human subjects with chronic alcohol abuse or dependence. These glial cellular changes appear to parallel and may largely explain structural and functional alterations detected using neuroimaging techniques in subjects with alcohol use disorders (AUDs). Moreover, due to the crucial roles of astrocytes and oligodendrocytes in neurotransmission and signal conduction, these cells are very likely major players in the molecular mechanisms underpinning alcoholism-related connectivity disturbances between the PFC and relevant interconnecting brain regions...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29605073/non-intensive-care-unit-management-of-acute-liver-failure
#8
REVIEW
Andres F Carrion, Paul Martin
Acute liver failure (ALF) is an uncommon syndrome with a highly variable and unpredictable clinical course. The initial diagnostic evaluation is typically performed in a non-intensive care unit (ICU) setting, like the emergency department or general hospital ward. Prompt restoration of intravascular volume with intravenous fluids and correction of electrolyte, metabolic, and acid-base disturbances are important initial interventions in the management of ALF and can be safely accomplished in non-ICU settings in many patients...
May 2018: Clinics in Liver Disease
https://www.readbyqxmd.com/read/29605071/the-clinical-spectrum-and-manifestations-of-acute-liver-failure
#9
REVIEW
Sarah Zahra Maher, Ian Roy Schreibman
Acute liver failure (ALF) is a rare life-threatening condition characterized by rapid progression and death. Causes vary according to geographic region, with acetaminophen and drug-induced ALF being the most common causes in the United States. Determining the cause aids in predicting the prognosis and the presentation of manifestations and guides providers to perform cause-specific management. At initial presentation, nonspecific symptoms are present but may progress to complications, including cerebral edema, infection, coagulopathy, renal failure, cardiopulmonary failure, and acid-base and/or metabolic disturbances...
May 2018: Clinics in Liver Disease
https://www.readbyqxmd.com/read/29604354/thrombin-like-enzymes-from-snake-venom-structural-characterization-and-mechanism-of-action
#10
REVIEW
Anwar Ullah, Rehana Masood, Ijaz Ali, Kifayat Ullah, Hamid Ali, Haji Akbar, Christian Betzel
Snake venom thrombin-like enzymes (SVTLEs) constitute the major portion (10-24%) of snake venom and these are the second most abundant enzymes present in the crude venom. During envenomation, these enzymes had shown prominently the various pathological effects, such as disturbance in hemostatic system, fibrinogenolysis, fibrinolysis, platelet aggregation, thrombosis, neurologic disorders, activation of coagulation factors, coagulant, procoagulant etc. These enzymes also been used as a therapeutic agent for the treatment of various diseases such as congestive heart failure, ischemic stroke, thrombotic disorders etc...
March 28, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29601848/food-safety-using-nmr-based-metabolomics-assessment-of-the-atlantic-bluefin-tuna-thunnus-thynnus-from-the-mediterranean-sea
#11
Tiziana Cappello, Alessia Giannetto, Vincenzo Parrino, Giuseppe De Marco, Angela Mauceri, Maria Maisano
Seafood is a valuable component of human diet because of its nutritional properties. The Atlantic bluefin tuna Thunnus thynnus is a scombroid fish highly appreciated as seafood worldwide. Being a top pelagic predator, concerns have been raised over human health risks due to its consumption. Therefore, herein it was comprehensively evaluated the health status and potential metabolite shifts between sexes of bluefin tuna from the Mediterranean Sea, proved to bioaccumulate environmental obesogens, namely polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) at hepatic level...
March 27, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29596832/variations-in-gut-microbiota-and-fecal-metabolic-phenotype-associated-with-fenbendazole-and-ivermectin-tablets-by-16s-rrna-gene-sequencing-and-lc-ms-based-metabolomics-in-amur-tiger
#12
Fengping He, Jiancheng Zhai, Le Zhang, Dan Liu, Yue Ma, Ke Rong, Yanchun Xu, Jianzhang Ma
BACKGROUND: The Amur tiger is one of the most endangered species in the world, and the healthy population of captive Amur tigers assists the recovery of the wild population. Gut microbes have been shown to be important for human disease and health, but little research exists regarding the microbiome of Amur tigers in captivity. METHODS: In this study, we used an integrated approach of 16S rRNA gene sequencing combined with ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS)-based metabolomics to analyze the effects of Fenbendazole and Ivermectin Tablets on the gut microbiota and fecal metabolic phenotype of the Amur tiger...
March 26, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29593311/mutations-in-the-cds-and-promoter-of-bjua07-clv1-cause-a-multilocular-trait-in-brassica-juncea
#13
Lu Xiao, Xin Li, Fei Liu, Zhi Zhao, Liang Xu, Cuiping Chen, Yanhua Wang, Guoxia Shang, Dezhi Du
Multilocular trait has recently attracted considerable attention for its potential to increase yield. Our previous studies indicated that two genes (Bjln1 and Bjln2) are responsible for multilocular siliques in Brassica juncea and the Bjln1 gene has been delimited to a 208-kb region. In present study, the Bjln1 gene was successfully isolated using the map-based cloning method. Complementation test indicated that the BjuA07.CLV1 (equivalent to BjLn1) could rescue the multilocular phenotype and generate bilocular siliques...
March 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29590191/gut-bone-axis-response-to-dietary-replacement-of-soybean-meal-with-raw-low-tannin-faba-bean-seeds-in-broiler-chickens
#14
Ewa Tomaszewska, Piotr Dobrowolski, Renata Klebaniuk, Małgorzata Kwiecień, Agnieszka Tomczyk-Warunek, Sylwia Szymańczyk, Sylwester Kowalik, Anna Milczarek, Tomasz Blicharski, Siemowit Muszyński
It seems that faba bean (FB) seeds could be a good protein-energy component in animal feed, but the presence of anti-nutritional substances limits their use as a substitute of soybean meal. The aim of the study was to examine the influence of different concentrations of raw, low-tannin, FB seeds on the gut-bone axis in Ross 308 broilers. One-day old chickens were randomly subjected to one of the 3 dietary treatments: the control group was fed standard diet based on soybean meal and without FB seeds, and two groups were fed 8%/15% and 16%/22% of raw low-tannin FB seeds in the starter and grower, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29571133/lc-ms-based-serum-fingerprinting-reveals-significant-dysregulation-of-phospholipids-in-chronic-heart-failure
#15
M Marcinkiewicz-Siemion, M Ciborowski, K Ptaszynska-Kopczynska, A Szpakowicz, A Lisowska, M Jasiewicz, E Waszkiewicz, A Kretowski, W J Musial, K A Kaminski
Cardiac and extracardiac lipid metabolism is known to be significantly altered in the course of the heart failure with reduced ejection fraction (HF-REF), however the precise mechanisms are not fully elucidated. The aim of the study was to use of untargeted metabolomics to identify and validate changes in the blood metabolites profile, occurring as a result of HF-REF development. The analyses were performed first in the derivation set (36 chronic HF-REF patients and 19 controls without the disease) and repeated in validation cohort (31 chronic HF-REF patients and 20 controls)...
March 15, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29563235/haloperidol-ameliorates-androgen-induced-behavioral-deficits-in-developing-male-rats
#16
Chunxiao Qi, Xiaoming Ji, Guoliang Zhang, Yunxiao Kang, Yuanxiang Huang, Rui Cui, Shuangcheng Li, Huixian Cui, Geming Shi
The purpose of present study was to infer the potential effects of testosterone increase in some male-based childhood-onset neuropsychiatric disorders, such as Tourette syndrome. Thus, the influence of early postnatal androgen exposure upon the neurobehaviors and its possible neural basis were investigated in the study. Male pup rats received consecutive 14-day testosterone propionate (TP) subcutaneous injection from postnatal day (PND) 7. The TP treatment produced the hyperactive motor behavior and grooming behavior as well as the increased levels of dopamine, tyrosine hydroxylase and dopamine transporter in the mesodopaminergic system and the elevated levels of serotonin in the nucleus accumbens, without affecting the levels of glutamate, γ-aminobutyric acid, norepinephrine and histamine in the caudate putamen and nucleus accumbens of PND21 and PND49 rats...
March 21, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29562214/tissue-specific-molecular-and-cellular-toxicity-of-pb-in-the-oyster-crassostrea-gigas-mrna-expression-and-physiological-studies
#17
Jie Meng, Wen-Xiong Wang, Li Li, Guofan Zhang
Lead (Pb) is one of the ubiquitous and toxic elements in aquatic environment. In oysters, gills and digestive glands are the main target organs for Pb-induced toxicity, but there is limited information on the molecular mechanisms underlying its toxicity. The present study investigated the Pb-induced toxicity mechanisms in the Pacific oyster (Crassostrea gigas) based on transcriptome, phenotypic anchoring, and validation of targeted gene expression. Gene ontology and pathway enrichment analyses revealed the differential Pb toxicity mechanisms in the tissues...
March 13, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29558152/bacteria-mediated-tumor-therapy-utilizing-photothermally-controlled-tnf-%C3%AE-expression-via-oral-administration
#18
Jin-Xuan Fan, Zi-Hao Li, Xin-Hua Liu, Diwei Zheng, Ying Chen, Xian-Zheng Zhang
Oral drug administration is widely adopted for diverse drugs, and enjoys the convenience of use and capbility to reach different parts of the body via the bloodstream. However, it is generally not feasible for biomacromolecular anti-tumor drugs such as protein and nucleic acids due to the the limited absorption through gastrointestinal tract (GIT) and the poor tumor targeting. Here, we report a non-invasive thermally-sensitive programmable therapetic system using bacteria E. coli MG1655 as an vehicle for tumor treatments via oral administration...
March 20, 2018: Nano Letters
https://www.readbyqxmd.com/read/29516892/uric-acid-levels-in-patients-on-antituberculosis-drugs-in-the-southwest-region-of-cameroon
#19
Benjamin David Thumamo Pokam, Jude E Enoh, Aniekan-Augusta O Eyo, Nse O Umoh, Prisca W Guemdjom
Background: Antituberculosis drugs (ATDs) efficiently combat Mycobacterium tuberculosis either through direct molecular interactions or those of its metabolites. However, a variety of adverse effects have been reported, leading to frequent interruptions of treatment. To investigate the possible metabolic disturbances resulting from antituberculosis (TB) treatment, the uric acid (UA) level of patients on ATDs was measured in the southwest region of Cameroon. Methods: This hospital-based cross-sectional study involved 96 TB patients on ATDs and 32 controls who were neither on ATDs nor any other treatment that could increase UA levels...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29502536/metabolomics-analysis-of-serum-in-a-rat-heroin-self-administration-model-undergoing-reinforcement-based-on-1-h-nuclear-magnetic-resonance-spectra
#20
Tingting Ning, Changlong Leng, Lin Chen, Baomiao Ma, Xiaokang Gong
BACKGROUND: Understanding the process of relapse to abused drugs and ultimately developing treatments that can reduce the incidence of relapse remains the primary goal for the study of substance dependence. Therefore, exploring the metabolite characteristics during the relapse stage is valuable. METHODS: A heroin self-administered rat model was employed, and analysis of the1 H-nuclear magnetic resonance-based metabolomics was performed to investigate the characteristic metabolite profile upon reintroduction to the drug after abstinence...
March 5, 2018: BMC Neuroscience
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