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https://www.readbyqxmd.com/read/28632590/comparison-of-anterior-and-posterior-surgery-for-degenerative-cervical-myelopathy-an-mri-based-propensity-score-matched-analysis-using-data-from-the-prospective-multicenter-aospine-csm-north-america-and-international-studies
#1
So Kato, Aria Nouri, Dongjin Wu, Satoshi Nori, Lindsay Tetreault, Michael G Fehlings
BACKGROUND: Surgeons often choose between 2 different approaches (anterior and posterior) for surgical treatment of degenerative cervical myelopathy on the basis of imaging features of spinal cord compression, the number of levels affected, and the spinal alignment. However, there is a lack of consensus on which approach is preferable. The objective of the present study was to use magnetic resonance imaging (MRI)-based propensity-score-matched analysis to compare postoperative outcomes between the anterior and posterior surgical approaches for degenerative cervical myelopathy...
June 21, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28625905/the-influence-of-mri-features-on-surgical-decision-making-in-degenerative-cervical-myelopathy-results-from-a-global-survey-of-aospine-international-members
#2
Aria Nouri, Allan R Martin, Anick Nater, Christopher D Witiw, So Kato, Lindsay Tetreault, Hamed Reihani-Kermani, Carlo Santaguida, Michael G Fehlings
OBJECTIVE: We conducted a survey to understand how specific pathologic features on MRI influence surgeons toward an anterior or posterior surgical approach in Degenerative Cervical Myelopathy (DCM) . METHODS: A questionnaire was sent out to 6,179 AOSpine International members via email. This included 18 questions on a 7-point Likert scale regarding how MRI features influence the respondent's decision to perform an anterior or posterior surgical approach. Influence was classified based on the mean and mode...
June 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28623897/altered-somatosensory-profile-according-to-quantitative-sensory-testing-in-patients-with-degenerative-lumbar-spine-disorders-scheduled-for-surgery
#3
Yvonne Lindbäck, Hans Tropp, Paul Enthoven, Björn Gerdle, Allan Abbott, Birgitta Öberg
BACKGROUND: Somatosensory profiling in affected and non-affected body regions can strengthen our insight regarding the underlying pain mechanisms, which can be valuable in treatment decision making and to improve outcomes, in patients with degenerative lumbar spine disorders pre-surgery. The aim was to describe somatosensory profiles in patients with degenerative lumbar spine disorders, to identify the proportion with altered somatosensory profile, and to analyze demographic characteristics, self-reported function, pain, and health pre- and 3 months post-surgery...
June 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28620118/role-of-p38-mapk-pathway-in-the-effects-of-high-magnitude-compression-on-nucleus-pulposus-cell-senescence-in-a-disc-perfusion%C3%A2-culture
#4
Pei Li, Ruijie Zhang, Yuan Xu, Lei Song, Qiang Zhou
Nucleus pulposus (NP) cell senescence is a typical pathological feature within the degenerative intervertebral disc. As a potential inducing and aggregating factor of disc degeneration, mechanical overloading affects disc biology in multiple ways. This study was to investigate the NP cell senescence-associated phenotype under intermittent high compression in an ex vivo disc bioreactor culture, and the role of the p38-MAPK pathway in this regulatory process. Porcine discs were cultured in culture chambers of a self-developed mechanically active bioreactor and subjected to different magnitudes of dynamic compression (low-magnitude and high-magnitude: 0...
June 15, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28608941/tgf-%C3%AE-stimulates-expression-of-chondroitin-polymerizing-factor-in-nucleus-pulposus-cells-through-the-smad3-rhoa-rock1-and-mapk-signaling-pathways
#5
Bo Hu, Chen Xu, Peng Cao, Ye Tian, Ying Zhang, Changgui Shi, Jun Xu, Wen Yuan, Huajiang Chen
The enzyme chondroitin polymerizing factor (ChPF) is primarily involved in extension of the chondroitin sulfate backbone required for the synthesis of sulfated glycosaminoglycan (sGAG). Transforming growth factor beta (TGF-β) upregulates sGAG synthesis in nucleus pulposus cells; however, the mechanisms mediating this induction are incompletely understood. Our study demonstrated that ChPF expression was negatively correlated with the grade of degenerative intervertebral disc disease. Treatment of nucleus pulposus cells with TGF-β induced ChPF expression and enhanced Smad2/3, RhoA/ ROCK activation, and the JNK, p38 and ERK1/2 MAPK signaling pathways...
June 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28604488/anterior-cervical-discectomy-and-fusion-outcomes-over-10-years-a-prospective-study
#6
Glenn R Buttermann
STUDY DESIGN: Prospective cohort study with >10-year follow-up. OBJECTIVE: To assess the long-term, >10-year, clinical outcomes of anterior cervical discectomy and fusion (ACDF) and to compare outcomes based on primary diagnosis of disc herniation; stenosis or advanced degenerative disc disease (DDD); number of levels treated; and preexisting adjacent level degeneration. SUMMARY OF BACKGROUND DATA: ACDF is a proven treatment for patients with stenosis and disc herniation and results in significantly improved short- and intermediate-term outcomes...
June 9, 2017: Spine
https://www.readbyqxmd.com/read/28603572/fibroblast-transplantation-results-to-the-degenerated-rabbit-lumbar-intervertebral-discs
#7
Ibrahim Halil Ural, Kerem Alptekin, Aysegul Ketenci, Seyhun Solakoglu, Hasan Alpak, Süleyman Özyalçın
BACKGROUND: Our study is an analysis of the histological and radiological changes in degenerated lumbar intervertebral discs, after transplantation of fibroblasts in rabbits. With that study we aimed to show the viability of the fibroblasts injected to the degenerated discs, and observe their potential for further studies. METHOD: The apoptosis of the cell is one of the factors at the disc degeneration process. Fibroblasts may act as mesenchymal stem cells at the tissue to which they are injected and they may replace the apoptotic cells...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28600230/cytokine-and-chemokine-profile-changes-in-patients-with-lower-segment-lumbar-degenerative-spondylolisthesis
#8
Juraj Sutovsky, Martin Benco, Martina Sutovska, Michaela Kocmalova, Lenka Pappova, Juraj Miklusica, Andrej Frano, Egon Kurca
BACKGROUND: Lumbar degenerative spondylolisthesis (DS) develops as a result of inflammatory and remodeling processes in facet joints (FJs). Several inflammatory cytokines are involved in the osteoarthritic and remodeling changes that occur and in low-back and/or radicular pain, the most prevalent clinical symptom of disease. This study improves knowledge related to the roles that 27 cytokines, chemokines and growth factors play in the pathophysiology of lumbar DS. MATERIAL AND METHODS: Cytokine levels were examined using capture sandwich immunoassay using the Bio-Plex(®) 200 System and the Bio-PlexTM Human Cytokine Standard 27-Plex, Group I (Bio-Rad, Hercules, California, USA) separately in intervertebral discs (IVDs) and FJ bone tissue...
June 6, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28598895/the-concurrent-use-of-lumbar-total-disc-arthroplasty-and-anterior-lumbar-interbody-fusion-the-lumbar-hybrid-procedure-for-the-treatment-of-multi-level-symptomatic-degenerative-disc-disease-a-prospective-study
#9
Matthew Scott-Young, Laurence McEntee, Ben Schram, Evelyne Rathbone, Wayne Hing, David Nielsen
STUDY DESIGN: A prospective study. OBJECTIVE: The aim of this paper is to evaluate clinical and patient outcomes post combined Total Disc Arthroplasty (TDA) and Anterior Lumbar Interbody Fusion (ALIF), known as hybrid surgery for the treatment of multi-level symptomatic degenerative disc disease (DDD). SUMMARY OF BACKGROUND DATA: Class I studies comparing the treatment of one level lumbar DDD with TDA and ALIF have confirmed the effectiveness of those treatments through clinical and patient outcomes...
June 8, 2017: Spine
https://www.readbyqxmd.com/read/28594131/optimization-of-puncture-injury-to-rat-caudal-disc-for-mimicking-early-degeneration-of-intervertebral-disc
#10
Ming-Hsiao Hu, Kai-Chiang Yang, Yeong-Jang Chen, Yuan-Hui Sun, Feng-Huei Lin, Shu-Hua Yang
The caudal discs of rats have been proposed as a puncture model in which intervertebral disc (IVD) degeneration can be induced and novel therapies can be tested. For biological repair, treatments for ongoing IVD degeneration are ideally administered during the earlier stages. The purpose of this study was to elucidate the optimal puncture needle size for creating a model that mimicked the earlier stages of IVD degeneration. According to the disc height index, histologic score and MRI grading, a puncture needle sized 21G or larger induced rapid degenerative processes in rat caudal discs during the initial 2-4 weeks...
June 8, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28588682/comparison-of-biological-characteristics-of-nucleus-pulposus-mesenchymal-stem-cells-derived-from-non-degenerative-and-degenerative-human-nucleus-pulposus
#11
Zhiwei Jia, Pushan Yang, Yaohong Wu, Yong Tang, Yachao Zhao, Jianhong Wu, Deli Wang, Qing He, Dike Ruan
Cell therapy using mesenchymal stem cells provides a promising approach for the treatment of intervertebral disc degeneration (IDD). In recent years, human nucleus pulposus mesenchymal stem cells (NPMSCs) have been identified in nucleus pulposus tissue and displayed great potential for the regeneration of IDD. However, biological differences between non-degenerative and degenerative nucleus pulposus-derived NPMSCs have remained to be defined. The aim of the present study was to compare the biological characteristics of human NPMSCs derived from non-degenerative and degenerative nucleus pulposus...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28586025/protective-role-of-17%C3%AE-estradiol-on-tumor-necrosis-factor-%C3%AE-induced-apoptosis-in-human-nucleus-pulposus-cells
#12
Huan Liu, Si-Dong Yang, Ying Xu, Sheng-Hua Ning, Tao Wang, Da-Long Yang, Wen-Yuan Ding
The molecular mechanisms underlying protection and pathogenesis in spinal degenerative diseases remain unclear. Tumor necrosis factor-α (TNF-α) has been demonstrated to induce apoptosis of inte rvertebral disc (IVD) cells during IVD degeneration, and 17β‑estradiol (17β‑E2) has a protective effect against IVD cell apoptosis. However, the underlying molecular mechanism by which 17β‑E2 protects nucleus pulposus (NP) cells remains to be investigated. The aim of the present study was to evaluate whether 17β‑E2 modulates apoptosis of human NP cells induced by TNF‑α...
June 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28583914/association-between-col11a1-rs1337185-and-adamts5-rs162509-gene-polymorphisms-and-lumbar-spine-pathologies-in-chinese-han-population-an-observational-study
#13
Hua Jiang, Qinghua Yang, Jie Jiang, Xinli Zhan, Zengming Xiao
OBJECTIVES: A previous study identified a significant association between several single nucleotide polymorphisms (SNPs) and lumbar disc degeneration (LDD) in Indians. To validate the association between these SNPs and specific lumbar spine pathologies, we performed a case-control study in Chinese Han population. DESIGN: An observational study. SETTING: University Hospital in Nanning, China. PARTICIPANTS: This study included 428 patients with LDD and 400 normal controls...
June 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28583869/total-disc-replacement-versus-multidisciplinary-rehabilitation-in-patients-with-chronic-low-back-pain-and-degenerative-discs-eight-year-follow-up-of-a-randomized-controlled-multicenter-trial
#14
Håvard Furunes, Kjersti Storheim, Jens Ivar Brox, Lars Gunnar Johnsen, Jan Sture Skouen, Eric Franssen, Tore K Solberg, Leiv Sandvik, Christian Hellum
BACKGROUND CONTEXT: Lumbar total disc replacement is a treatment option for selected patients with chronic low back pain that is non-responsive to conservative treatment. The long-term results of disc replacement compared to multidisciplinary rehabilitation have not been reported previously. PURPOSE: We aimed to assess the long-term relative efficacy of lumbar total disc replacement compared to multidisciplinary rehabilitation. DESIGN: We undertook a multicenter randomized controlled trial at five university hospitals in Norway...
June 2, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28582418/an-in-vivo-comparison-study-in-goats-for-a-novel-motion-preserving-cervical-joint-system
#15
Jie Qin, Chenguang Zhao, Dong Wang, Bo Zhao, Jun Dong, Haopeng Li, Rongxia Sang, Shuang Wang, Jiao Fu, Rangrang Kong, Xijing He
Cervical degenerative disease is one of the most common spinal disorders worldwide, especially in older people. Anterior cervical corpectomy and fusion (ACCF) is a useful method for the surgical treatment of multi-level cervical degenerative disease. Anterior cervical disc replacement (ACDR) is considered as an alternative surgical method. However, both methods have drawbacks, particularly the neck motion decrease observed after arthrodesis, and arthroplasty should only be performed on patients presenting with cervical disc disease but without any vertebral body disease...
2017: PloS One
https://www.readbyqxmd.com/read/28579261/are-axial-intervertebral-disc-biomechanics-determined-by-osmosis
#16
Pieter-Paul A Vergroesen, Kaj S Emanuel, Mirte Peeters, Idsart Kingma, Theodoor H Smit
The intervertebral disc faces high compressive forces during daily activities. Axial compression induces creeping fluid loss and reduction in disc height. With degeneration, disc fluids and height are progressively lost, altering biomechanics. It is assumed that this reduction of fluids is caused by a decline of osmolality within the disc due to proteoglycan depletion. Here we investigate the isolated effect of a reduction in osmosis on the biomechanical properties of the intervertebral disc. Continuous diurnal loading was applied to healthy caprine intervertebral discs in a loaded disc culture system for a total of 6days...
May 8, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28576669/impact-of-autologous-bone-marrow-derived-stem-cells-on-degenerative-changes-of-articulating-surfaces-associated-with-the-arthritic-temporomandibular-joint-an-experimental-study-in-rabbits
#17
Ahmed Abdelfatah Zaki, Mohamed Zaghloul, Mohamed E Helal, Noha Ahmed Mansour, Mohammed E Grawish
PURPOSE: This study evaluated the effect of bone marrow-derived stem cells (BMSCs) on degenerative changes of TMJ associated with bovine collagen type II (BCII) induced-arthritis. MATERIALS AND METHODS: Fifty rabbits were divided into 3 groups. Group I (n = 10) received no treatment. Group II (n = 20) was divided into 2 subgroups according to treatment type. One subgroup (n = 10) received an intra-articular (IA) injection of phosphate buffered saline (PBS) and the other (n = 10) received an IA injection of PBS plus BMSCs...
May 10, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28575461/adjacent-segment-degeneration-after-anterior-cervical-discectomy-and-fusion-with-an-autologous-iliac-crest-graft-a-magnetic-resonance-imaging-study-of-59-patients-with-a-mean-follow-up-of-27%C3%A2-yr
#18
Benedikt W Burkhardt, Andreas Simgen, Gudrun Wagenpfeil, Wolfgang Reith, Joachim M Oertel
BACKGROUND: Anterior cervical decompression and fusion (ACDF) is a widely accepted surgical technique for the treatment of degenerative disc disease. ACDF is associated with adjacent segment degeneration (ASD). OBJECTIVE: To assess whether physiological aging of the spine would overcome ASD by comparing adjacent to adjoining segments more than 18 yr after ACDF. METHODS: Magnetic resonance imaging of 59 (36 male, 23 female) patients who underwent ACDF was performed to assess degeneration...
May 30, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28574978/adjacent-segment-degeneration-following-anterior-cervical-discectomy-and-fusion-versus-the-bryan-cervical-disc-arthroplasty
#19
Suo-Zhou Yan, Jun Di, Yong Shen
BACKGROUND Anterior cervical discectomy and fusion (ACDF) is an established treatment for degenerative disease of the cervical disc, but adjacent segment degeneration or instability may develop long term. The aim of this study was to investigate the risk factors for adjacent segment degeneration following ACDF compared with the use of the Bryan artificial disc for cervical disc arthroplasty (CDA). MATERIAL AND METHODS A prospective comparative study included 93 patients who underwent ACDF or CDA with the Bryan artificial cervical disc between 2002 and 2004, and who had more than eight years of follow-up...
June 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28574417/study-on-the-expression-of-nerve-growth-associated-protein-43-in-rat-model-of-intervertebral-disc-degeneration
#20
H Jiang, J Wang, B Xu, Q Yang, Y Liu
OBJECTIVE: In the present work we studied the expression of nerve growth associated protein (GAP-43) in a rat model of intervertebral disc degeneration. METHODS: 16 healthy adult SD rats, male or female, with an average weight 220g were selected. FluoroGold was injected in L5-L6 disc as the tracer. After 7 days, Freund's adjuvant was then injected to build model of intervertebral disc degeneration. After 1, 3, 7 and 14 days of modeling immune-histochemical method was used to detect the T13-L6 dorsal root ganglion and positive expression of GAP-43, TNF-α and IL-1 in L5-L6 intervertebral disc; RT-PCR method was used to detect GAP-43 mRNA and Western blot method was utilized to detect the expression levels of protein...
June 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
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