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https://www.readbyqxmd.com/read/28935976/tgf-%C3%AE-1-suppresses-ccl3-4-expression-through-the-erk-signaling-pathway-and-inhibits-intervertebral-disc-degeneration-and-inflammation-related-pain-in-a-rat-model
#1
Jian Zhang, Zemin Li, Fan Chen, Hui Liu, Hua Wang, Xiang Li, Xianguo Liu, Jianru Wang, Zhaomin Zheng
The objective of this study was to investigate the regulatory effects of TGF-β1 on CCL3/4 expression and inflammation-related pain during intervertebral disc degeneration (IVDD). TGF-β1 and CCL3/4 expression patterns in different degenerative human nucleus pulposus (NP) tissues were measured by qPCR and immunohistochemistry (IHC), and the effects of TGF-β1 on CCL3/4 expression were measured by qPCR, ELISA and immunofluorescence. The roles of NF-κB and MAPK in TGF-β1-mediated CCL3/4 promoter activity were studied using siRNAs, western blotting and qPCR...
September 22, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28934790/factors-associated-with-successful-responses-to-transforaminal-balloon-adhesiolysis-for-chronic-lumbar-foraminal-stenosis-retrospective-study
#2
Doo Hwan Kim, Seong-Sik Cho, Yeon-Jin Moon, Koo Kwon, Kunhee Lee, Jeong-Gil Leem, Jin-Woo Shin, Ji Hyun Park, Seong-Soo Choi
BACKGROUND: Recently, transforaminal balloon adhesiolysis was introduced to manage patients with chronic radicular pain occurring with or without low back pain. However, the factors associated with successful responses to transforaminal balloon adhesiolysis are not known. OBJECTIVE: To evaluate the factors associated with successful responses to transforaminal balloon adhesiolysis for chronic lumbar spinal stenosis. STUDY DESIGN: This is a retrospective observational study...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28929036/factors-affecting-length-of-stay-following-elective-anterior-and-posterior-cervical-spine-surgery
#3
Frank J Yuk, Akbar Y Maniya, Jonathan J Rasouli, Alexa M Dessy, Patrick J McCormick, Tanvir F Choudhri
Background Disease of the cervical spine is widely prevalent, most commonly secondary to degenerative disc changes and spondylosis. Objective The goal of the paper was to identify a possible discrepancy regarding the length of stay (LOS) between the anterior and posterior approaches to elective cervical spine surgery and identify contributing factors. Methods A retrospective study was performed on 587 patients (341 anterior, 246 posterior) that underwent elective cervical spinal surgery between October 2001 and March 2014...
July 10, 2017: Curēus
https://www.readbyqxmd.com/read/28927213/ten-step-minimally-invasive-spine-lumbar-decompression-and-dural-repair-through-tubular-retractors
#4
Mohamed Abdelatif Boukebir, Connor David Berlin, Rodrigo Navarro-Ramirez, Tim Heiland, Karsten Schöller, Cameron Rawanduzy, Sertaç Kirnaz, Ajit Jada, Roger Härtl
BACKGROUND: Minimally invasive spine (MIS) surgery utilizing tubular retractors has become an increasingly popular approach for decompression in the lumbar spine. However, a better understanding of appropriate indications, efficacious surgical techniques, limitations, and complication management is required to effectively teach the procedure and to facilitate the learning curve. OBJECTIVE: To describe our experience and recommendations regarding tubular surgery for lumbar disc herniations, foraminal compression with unilateral radiculopathy, lumbar spinal stenosis, synovial cysts, and dural repair...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28918116/atherosclerotic-disease-and-its-relationship-to-lumbar-degenerative-disc-disease-facet-arthritis-and-stenosis-with-computed-tomography-angiography
#5
William J Beckworth, John F Holbrook, Lisa G Foster, Laura A Ward, James R Welle
BACKGROUND: The intervertebral disc is the largest avascular structure in the body. It relies on passive diffusion from arteries at the periphery of the disc for nutrition. Prior studies have suggested a correlation between vascular disease and lumbar degenerative disc disease (DDD) but the association with facet arthritis and stenosis has not been evaluated. OBJECTIVE: To evaluate the degree of lumbar artery stenosis, aortic atherosclerosis on computed tomography angiography (CTAs) and its relationship to lumbar DDD, facet arthritis and spinal canal stenosis...
September 13, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28910701/biomechanical-analysis-of-lumbar-decompression-surgery-in-relation-to-degenerative-changes-in-the-lumbar-spine-validated-finite-element-analysis
#6
Quan You Li, Ho-Joong Kim, Juhyun Son, Kyoung-Tak Kang, Bong-Soon Chang, Choon-Ki Lee, Hyun Sik Seok, Jin S Yeom
BACKGROUND: There are no studies about the biomechanical analysis of lumbar decompression surgery in relation to degenerative changes of the lumbar spine. Therefore, the purpose of this study was to compare, by using finite element (FE) analysis, the biomechanical changes of the lumbar spine in terms of annulus stress and nucleus pressure after two different kinds of lumbar decompression surgery in relation to disc degenerative changes. METHODS: The validated intact and degenerated FE models (L2-5) were used in this study...
September 6, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28899699/factors-associated-with-lumbar-disc-hernia-recurrence-after-microdiscectomy
#7
G Camino Willhuber, G Kido, M Mereles, J Bassani, M Petracchi, C Elizondo, M Gruenberg, C Sola
INTRODUCTION: Lumbar disc hernias are a common cause of spinal surgery. Hernia recurrence is a prevalent complication. OBJECTIVE: To analyse the risk factors associated with hernia recurrence in patients undergoing surgery in our institution. MATERIALS AND METHODS: Lumbar microdiscectomies between 2010 and 2014 were analysed, patients with previous surgeries, extraforaminales and foraminal hernias were excluded. Patients with recurrent hernia were the case group and those who showed no recurrence were the control group...
September 9, 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/28894792/influence-of-hla-matching-on-the-efficacy-of-allogeneic-mesenchymal-stromal-cell-therapies-for-osteoarthritis-and-degenerative-disc-disease
#8
Javier García-Sancho, Ana Sánchez, Aurelio Vega, David C Noriega, Mercedes Nocito
BACKGROUND: The necessity for more effective therapies for chronic osteoarticular diseases has led to the development of treatments based on mesenchymal stem cells (MSCs), the natural precursors of musculoskeletal tissue. Treatments with autologous MSCs yielded excellent results, with nearly 70% improvement of pain and disability in osteoarthritis and degenerative disc disease. Using allogeneic MSCs is logistically more convenient and would widen the pool of eligible patients, but potential immune rejection should be considered...
September 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28894678/radiographic-risk-factors-of-reoperation-following-minimally-invasive-decompression-for-lumbar-canal-stenosis-associated-with-degenerative-scoliosis-and-spondylolisthesis
#9
Minori Kato, Takashi Namikawa, Akira Matsumura, Sadahiko Konishi, Hiroaki Nakamura
STUDY DESIGN: Prospective cohort study. OBJECTIVE: Microsurgical bilateral decompression via a unilateral approach (MBDU), a minimally invasive surgical (MIS) decompression method, has been performed for numerous degenerative lumbar diseases, including degenerative lumbar scoliosis (DLS) or degenerative spondylolisthesis (DS), at our institution. In this study, we evaluated the appropriateness of MBDU for DLS or DS patients. METHODS: A total of 207 patients treated by MBDU were included (88 women and 119 men; mean age, 70 [40-86] years)...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28894375/impact-of-t1-slope-on-surgical-and-adjacent-segment-degeneration-after-bryan-cervical-disc-arthroplasty
#10
Peng Yang, Yongqian Li, Jia Li, Yong Shen
BACKGROUND: This retrospective study investigated an association between preoperative T1 slope and surgical and adjacent segment degeneration (SASD) after Bryan cervical disc arthroplasty (BCDA) in patients with cervical degenerative disc disease. METHODS: Based on preoperative standing lateral radiographs, 90 patients were classified according to T1 slope that was higher or lower than the 50th percentile (high T1 or low T1, 28 and 62 patients, respectively). Patients were also classified as SASD or non-SASD (38 and 52 patients, respectively) determined by radiographs at final follow-up...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28890222/identifying-subsets-of-patients-with-single-level-degenerative-disc-disease-for-lumbar-fusion-the-value-of-prognostic-tests-in-surgical-decision-making
#11
Victor E Staartjes, Pieter-Paul A Vergroesen, Dick J Zeilstra, Marc L Schröder
BACKGROUND CONTEXT: Fusion surgery for degenerative disc disease (DDD) has become a standard of care, albeit not without controversy. Outcomes are inconsistent and a superiority over conservative treatment is debatable. Proper patient selection is key to clinical success, and a comprehensive understanding of prognostic tests does not currently exist. PURPOSE: To investigate the value of prognostic tests and sociodemographic factors in predicting outcomes following lumbar fusion surgery for DDD...
September 7, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28888674/geographical-variations-in-clinical-presentation-and-outcomes-of-decompressive-surgery-in-patients-with-symptomatic-degenerative-cervical-myelopathy-analysis-of-a-prospective-international-multicenter-cohort-study-of-757-patients
#12
Michael G Fehlings, Branko Kopjar, Ahmed Ibrahim, Lindsay A Tetreault, Paul M Arnold, Helton Defino, Shashank Sharad Kale, S Tim Yoon, Giuseppe M Barbagallo, Ronald H M Bartels, Qiang Zhou, Alexander R Vaccaro, Mehmet Zileli, Gamaliel Tan, Yasutsugu Yukawa, Darrel S Brodke, Christopher I Shaffrey, Osmar Santos de Moraes, Eric J Woodard, Massimo Scerrati, Masato Tanaka, Tomoaki Toyone, Rick C Sasso, Michael E Janssen, Ziya L Gokaslan, Manuel Alvarado, Ciaran Bolger, Christopher M Bono, Mark B Dekutoski
BACKGROUND CONTEXT: Degenerative cervical myelopathy (DCM) is a progressive degenerative spine disease and the most common cause of spinal cord impairment in adults worldwide. There is a paucity of studies reporting on regional variations in demographics, clinical presentation, disease causation and surgical effectiveness. PURPOSE: To evaluate differences in demographics, causative pathology, management strategies, surgical outcomes, length of hospital stay and complications across four geographic regions...
September 6, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28887690/cervical-sagittal-alignment-after-different-anterior-discectomy-procedures-for-single-level-cervical-degenerative-disc-disease-randomized-controlled-trial
#13
Roland D Donk, Hisse Arnts, Wim I M Verhagen, Hans Groenewoud, Andre Verbeek, Ronald H M A Bartels
BACKGROUND: The effect of anterior cervical discectomy without fusion (ACD), ACD with fusion by stand-alone cage (ACDF) or with arthroplasty (ACDA) on cervical sagittal alignment is not known and is the subject of this study. METHODS: A total of 142 adult patients with single-level cervical disease were at random allocated to different procedures: ACD (45), ACDF (47) and ACDA (50). Upright cervical spine radiographs were obtained. Angles of the involved angle and the angle between C2 and C7 were determined...
September 8, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28887038/resveratrol-protects-against-mitochondrial-dysfunction-through-autophagy-activation-in-human-nucleus-pulposus-cells
#14
Baolong Zhang, Linfei Xu, Naiqiang Zhuo, Jieliang Shen
Intervertebral disc degeneration (IVDD) is closely related with aging, whereas mitochondrial damage is a common feature of aging that results in cell apoptosis. Resveratrol (RES) is a natural antioxidant that protects against mitochondrial dysfunction in various cells. This study aimed to investigate the protective role of RES against mitochondrial dysfunction and human nucleus pulposus cell (NPC) apoptosis. We found that mitochondrial dysfunction and NPC apoptosis could be induced under oxidative stress by 100 μmol/l of H2O2...
September 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28881110/endoscopic-spine-surgery
#15
REVIEW
Gun Choi, Chetan S Pophale, Bhupesh Patel, Priyank Uniyal
Surgical treatment of the degenerative disc disease has evolved from traditional open spine surgery to minimally invasive spine surgery including endoscopic spine surgery. Constant improvement in the imaging modality especially with introduction of the magnetic resonance imaging, it is possible to identify culprit degenerated disc segment and again with the discography it is possible to diagnose the pain generator and pathological degenerated disc very precisely and its treatment with minimally invasive approach...
September 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28878417/post-operative-salmonella-surgical-site-infection-in-a-dog
#16
Marc Kent, Lindsay Boozer, Eric N Glass, Susan Sanchez, Simon R Platt, Lisa M Freeman
Following decompressive surgery for degenerative lumbosacral stenosis, a 6-year-old German shepherd dog developed a subcutaneous infection at the surgical site and discospondylitis at the lumbosacral intervertebral disc. Salmonella enterica subsp. enterica, serotype Dublin was recovered from the surgical site. Salmonella of a different serovar was isolated from a sample of the raw meat-based diet that the owner fed the dog.
September 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28874973/inhibiting-vascular-endothelial-growth-factor-in-injured-intervertebral-discs-attenuates-pain-related-neuropeptide-expression-in-dorsal-root-ganglia-in-rats
#17
Jun Sato, Kazuhide Inage, Masayuki Miyagi, Yoshihiro Sakuma, Kazuyo Yamauchi, Masao Koda, Takeo Furuya, Junichi Nakamura, Miyako Suzuki, Go Kubota, Yasuhiro Oikawa, Takeshi Sainoh, Kazuki Fujimoto, Yasuhiro Shiga, Koki Abe, Hirohito Kanamoto, Masahiro Inoue, Hideyuki Kinoshita, Masaki Norimoto, Tomotaka Umimura, Kazuhisa Takahashi, Seiji Ohtori, Sumihisa Orita
STUDY DESIGN: An experimental animal study. PURPOSE: To evaluate effects of anti-vascular endothelial growth factor (VEGF) on the content and distribution of the calcitonin gene-related peptide (CGRP) in the dorsal ganglia in a rat model. OVERVIEW OF LITERATURE: Increased expression of VEGF in degenerative disc disease increases the levels of inflammatory cytokines and nerve ingrowth into the damaged discs. In animal models, increased levels of VEGF can persist for up to 2 weeks after an injury...
August 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28861198/lumbar-single-level-dynamic-stabilization-with-semi-rigid-and-full-dynamic-systems-a-retrospective-clinical-and-radiological-analysis-of-71-patients
#18
Ali Fahir Ozer, Tunc Oktenoglu, Emrah Egemen, Mehdi Sasani, Atilla Yilmaz, Deniz Ufuk Erbulut, Onur Yaman, Tuncer Suzer
BACKGROUND: This study compares the clinical and radiological results of three most commonly used dynamic stabilization systems in the field of orthopedic surgery. METHODS: A total of 71 patients underwent single-level posterior transpedicular dynamic stabilization between 2011 and 2014 due to lumbar degenerative disc disease. Three different dynamic systems used include: (1) the Dynesys system; (2) a dynamic screw with a PEEK rod; and (3) a full dynamic system (a dynamic screw with a dynamic rod; BalanC)...
September 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28853606/impact-of-the-quantity-of-intradiscal-cement-leak-on-the-progression-of-intervertebral-disc-degeneration
#19
B Jamjoom, S Patel, R Bommireddy, Z Klezl
Introduction We aim to assess the impact of the quantity of intradiscal cement leak during kyphoplasty on the rate of progression of degenerative changes in the affected disc. Methods Of 316 kyphoplasty procedures, we identified 32 episodes of intradiscal cement leak in 26 patients. The quantity of cement leaked was graded from I to IV. Disc degenerative changes were assessed at presentation and follow-up using radiographical scoring and magnetic resonance imaging (MRI) grading systems. Data for low-grade leaks (grade I) were compared with the medium- and high-grade leaks (grades II-IV) using a chi-squared test...
September 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28843706/variation-of-facet-joint-orientation-and-tropism-in-lumbar-degenerative-spondylolisthesis-and-disc-herniation-at-l4-l5-a-systematic-review-and-meta-analysis
#20
REVIEW
Ziyang Liu, Yuchen Duan, Xin Rong, Beiyu Wang, Hua Chen, Hao Liu
Although degenerative spondylolisthesis (DS) and lumber disc herniation (LDH) are common causes of back pain, the associations between the lumbar facet joint angle orientation and tropism in these conditions are still contentious. The objective of the meta-analysis was to identify the role of facet joint orientation and tropism on the development of lumbar degenerative disease, including DS and LDH. Electronic searches of PubMed and Embase were conducted up to April 2017. P value<0.05 was regarded as significant...
October 2017: Clinical Neurology and Neurosurgery
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