keyword
MENU ▼
Read by QxMD icon Read
search

degenerative disc

keyword
https://www.readbyqxmd.com/read/28087442/hydrogen-sulfide-protects-against-endoplasmic-reticulum-stress-and-mitochondrial-injury-in-nucleus-pulposus-cells-and-ameliorates-intervertebral-disc-degeneration
#1
Daoliang Xu, Haiming Jin, Jianxia Wen, Jiaoxiang Chen, Deheng Chen, Ningyu Cai, Yongli Wang, Jianle Wang, Yu Chen, Xiaolei Zhang, Xiangyang Wang
It has been suggested that excessive apoptosis in intervertebral disc cells induced by inflammatory cytokines, such as interleukin (IL)-1β, is related to the process of intervertebral disc degeneration (IVDD). Hydrogen sulfide (H2S), a gaseous signaling molecule, has drawn attention for its anti-apoptosis role in various pathophysiological processes in degenerative diseases. To date, there has been no investigation of the correlation of H2S production and IVDD or of the effects of H2S on IL-1β-induced apoptosis in nucleus pulposus (NP) cells...
January 10, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28087395/lumbar-spinal-muscles-and-spinal-canal-study-by-mri-three-dimensional-reconstruction-in-adult-lumbar-spinal-stenosis
#2
Louis Boissière, Bertrand Moal, Olivier Gille, Elise De-Roquefeuil, Muriel Durieux, Ibrahim Obeid, Vincent Dousset, Jean-Marc Vital, Wafa Skalli
BACKGROUND: Lumbar spinal stenosis is degenerative disc disease most common manifestation. If stenosis degree seems poorly related to symptom severity, lumbar muscles role is recognized. Many studies report imaging methods, to analyze muscle volumes and fat infiltration (FI), but remain limited due to the difficulty to represent entire muscle volume variability. Recently a 3D muscle reconstruction protocol (using the deformation of a parametric specific object method (DPSO) and three point Dixon images) was reported...
January 10, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28086781/effects-of-the-intradiscal-implantation-of-stromal-vascular-fraction-plus-platelet-rich-plasma-in-patients-with-degenerative-disc-disease
#3
Comella Kristin, Silbert Robert, Parlo Michelle
BACKGROUND: Stromal vascular fraction (SVF) can easily be obtained from a mini-lipoaspirate procedure of fat tissue and platelet rich plasma (PRP) can be obtained from peripheral blood. The SVF contains a mixture of cells including ADSCs and growth factors and has been depleted of the adipocyte (fat cell) population. We evaluated the safety and efficacy of administering SVF and PRP intra-discally into patients with degenerative disc disease. METHODS: A total of 15 patients underwent a local tumescent liposuction procedure to remove approximately 60 ml of fat tissue...
January 13, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28081468/role-of-mir-15a-in-intervertebral-disc-degeneration-through-targeting-map3k9
#4
Ping Cai, Ting Yang, Xingjie Jiang, Minghui Zheng, Gang Xu, Jianlong Xia
BACKGROUND: Accumulating evidence indicates that microRNAs are involved in various cellular processes, including cell proliferation, differentiation, apoptosis and metastasis. miR-15a is an important regulator of immune responses and angiogenesis, endogenous controls as well as potential targets and hallmarks of cancer. However, the role of miR-15a in intervertebral disc degeneration (IDD) has not been elucidated. METHODS: Total RNA was extracted from degenerative nucleus pulposus (NP) tissues of 20 patients with IDD and NP cells, respectively...
January 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28068790/temporomandibular-disorders-old-ideas-and-new-concepts
#5
Thomas List, Rigmor Højland Jensen
Background Temporomandibular disorders (TMD) is an umbrella term for pain and dysfunction involving the masticatory muscles and the temporomandibular joints (TMJs). TMD is the most common orofacial pain condition. Its prominent features include regional pain in the face and preauricular area, limitations in jaw movement, and noise from the TMJs during jaw movements. TMD affects up to 15% of adults and 7% of adolescents. Chronic pain is the overwhelming reason that patients with TMD seek treatment. TMD can associate with impaired general health, depression, and other psychological disabilities, and may affect the quality of life of the patient...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28067882/skeletal-outcome-in-long-term-survivors-of-childhood-high-risk-neuroblastoma-treated-with-high-dose-therapy-and-autologous-stem-cell-rescue
#6
P Utriainen, A Vatanen, S Toiviainen-Salo, U Saarinen-Pihkala, O Mäkitie, K Jahnukainen
High-dose therapy and hematopoietic stem cell transplantation (HSCT) have been shown to improve survival rates in high-risk neuroblastoma (HR-NBL), but may cause adverse effects on the growing skeleton. We studied skeletal health in a national cohort of long-term survivors of HR-NBL (n=21; age 16-30 years, median 22 years) and in 20 healthy age- and sex-matched controls. In addition to clinical evaluation and measurement of bone mineral density (BMD) by dual-energy X-ray absorptiometry, we performed spinal magnetic resonance imaging...
January 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28064032/tmj-energy-densities-in-healthy-men-and-women
#7
L R Iwasaki, Y M Gonzalez, Y Liu, H Liu, M Markova, L M Gallo, J C Nickel
OBJECTIVE: Cartilage fatigue, due to mechanical work, may account for the early development of degenerative joint disease in the temporomandibular joint (TMJ), and why women are 3-times more likely to be afflicted. This study tested for gender differences in mechanical energy densities in women and men with healthy TMJs. DESIGN: Eighteen women and eighteen men gave informed consent. Research diagnostic criteria including imaging were used to ensure that subjects' TMJs were normal, without disc displacement or signs of degenerative joint disease...
January 4, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28052015/epoxyeicosanoids-prevent-intervertebral-disc-degeneration-in-vitro-and-in-vivo
#8
Jing Li, Hanfeng Guan, Huiyong Liu, Libo Zhao, Li Li, Yong Zhang, Peng Tan, Baoguo Mi, Feng Li
Intervertebral disc (IVD) degeneration is considered a common cause of low back pain. In the degenerating IVD, the production of pro-inflammatory cytokines, including IL-1 and TNF-α, progressively increases, contributing to the degenerative process. Epoxyeicosatrienoic acids (EETs), synthesized from arachidonic acid by cytochrome P450 enzymes, act as autocrine and paracrine effectors in regulating inflammation, cardiovascular functions, and angiogenesis. EETs were shown to be especially potent promoters of tissue regeneration...
December 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/28050537/spinopelvic-balance-evaluation-of-patients-with-degenerative-spondylolisthesis-l4l5-and-l4l5-herniated-disc-who-underwent-surgery
#9
Viviane Regina Hernandez Nunes, Charbel Jacob, Igor Machado Cardoso, José Lucas Batista, Marcus Alexandre Novo Brazolino, Thiago Cardoso Maia
OBJECTIVE: To correlate spinopelvic balance with the development of degenerative spondylolisthesis and disk herniation. METHODS: This was a descriptive retrospective study that evaluated 60 patients in this hospital, 30 patients with degenerative spondylolisthesis at the L4-L5 level and 30 with herniated disk at the L4-L5 level, all of whom underwent Surgical treatment. RESULTS: Patients with lumbar disk herniation at L4-L5 level had a mean tilt of 8...
November 2016: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28043848/surgical-treatment-of-degenerative-spondylolisthesis
#10
REVIEW
P Guigui, E Ferrero
Degenerative spondylolisthesis is a common pathology, often causing lumbar canal stenosis. There is, however, no strong consensus regarding the various medical and surgical treatments available. Surgery is indicated mainly for perceived functional impairment; when the indication is accepted, several questions determine the choice of surgical strategy. Improvement in neurological symptoms is one of the main treatment objectives. For this, it is useful to perform radicular decompression. Some authors recommend indirect decompression by interbody fusion (ALIF, TLIF, XLIF), others by means of an interspinous spacer but the most frequent technique is direct posterior decompression...
December 30, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28039556/microrna-15b-silencing-inhibits-il-1%C3%AE-induced-extracellular-matrix-degradation-by-targeting-smad3-in-human-nucleus-pulposus-cells
#11
Liang Kang, Cao Yang, Huipeng Yin, Kangcheng Zhao, Wei Liu, Wenbin Hua, Kun Wang, Yu Song, Ji Tu, Shuai Li, Rongjin Luo, Yukun Zhang
OBJECTIVES: To determine the role of microRNA-15b (miR-15b) in interleukin-1 beta (IL-1β)-induced extracellular matrix (ECM) degradation in the nucleus pulposus (NP). RESULTS: MiR-15b was up-regulated in degenerative NP tissues and in IL-1β-stimulated NP cells, as compared to the levels in normal controls (normal tissue specimens from patients with idiopathic scoliosis). Bioinformatics and luciferase activity analyses showed that mothers against decapentaplegic homolog 3 (SMAD3), a key mediator of the transforming growth factor-β signaling pathway, was directly targeted by miR-15b...
December 30, 2016: Biotechnology Letters
https://www.readbyqxmd.com/read/28032706/correlations-of-japanese-orthopaedic-association-scoring-systems-with-gait-parameters-in-patients-with-degenerative-spinal-diseases
#12
Chen-Fan Zheng, Yan-Cheng Liu, Yong-Cheng Hu, Qun Xia, Jun Miao, Ji-Dong Zhang, Kuan Zhang
OBJECTIVE: Japanese Orthopaedic Association (JOA) scoring systems were developed to evaluate the neurological function of patients with cervical or lumbar degeneration. As patient-based and multi-dimensional clinical evaluation tools, these systems should be capable of reflecting the walking disability of patients. The association between JOA scores and gait parameters, however, are not well characterized. The purpose of this study was to determine the correlations between JOA scores and gait parameters of patients with cervical spondylotic myelopathy (CSM) and lumbar intervertebral disc herniation (LDH)...
November 2016: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28031951/electromagnetic-fields-in-the-treatment-of-chronic-lower-back-pain-in-patients-with-degenerative-disc-disease
#13
Amarjit S Arneja, Alan Kotowich, Doug Staley, Randy Summers, Paramjit S Tappia
AIM: To examine the effects of low-amplitude, low frequency electromagnetic field therapy (EMF) therapy in patients with persistent chronic lower back pain associated with degenerative disc disease. DESIGN: Double-blind, randomized and placebo controlled. INTERVENTION: EMF using a medical device resonator; control group underwent same procedures, except the device was turned off. OUTCOME MEASURES: Pain reduction and mobility...
March 2016: Future Science OA
https://www.readbyqxmd.com/read/28028952/mastalgia-due-to-degenerative-changes-of-the-spine
#14
Okay Pirti, Aziz M Barlas, Serdar Kuru, Selim Temel, Mustafa K Urhan, Kemal Kismet, Adnan Hasanoglu, Osman Guler
BACKGROUND: Mastalgia is a common and enigmatic condition; the cause and optimal treatment are still inadequately defined. Cervical radiculopathy, which is the result of cervical nerve root pathology often caused by spaceoccupying lesions such as cervical disc herniation, spondylosis, or osteophytosis, is frequently encountered in physical therapy. OBJECTIVES: The aim of the study was to evaluate the incidence of vertebral pathologies in patients with non-cyclic mastalgia and the efficacy of conservative treatment of these pathologies on relieving breast pain...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28026727/radiological-changes-after-interspinous-dynamic-stabilisation-for-lateral-stenosis-of-lumbar-spinal-canal-a-parallel-group-randomised-trial
#15
J Mohar, M Cimerman
PURPOSE OF THE STUDY Interspinous dynamic stabilisation devices (IDSDs) are used for stabilisation and indirect decompression of the spinal motion segment in minimally invasive treatment of degenerative conditions of lumbar spine. Good methodological quality studies on biomechanical effects of IDSDs are lacking in scientific literature. The purpose of this study was to evaluate the biomechanical effect of dynamic IDSD implantation on a spinal motion segment. MATERIAL AND METHODS We conducted a parallel group randomised trial (RT) on twelve patients, comparing radiological stabilisation and indirect decompression outcome measures between groups of patients with an isolated degenerative condition of L4-L5 motion segment and unilateral L5 nerve root radiculopathy...
2016: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28019241/a-regenerative-approach-towards-recovering-the-mechanical-properties-of-degenerated-intervertebral-discs-genipin-and-platelet-rich-plasma-therapies
#16
Mohammad Nikkhoo, Jaw-Lin Wang, Masoud Abdollahi, Yu-Chun Hsu, Mohamad Parnianpour, Kinda Khalaf
Degenerative disc disease, associated with discrete structural changes in the peripheral annulus and vertebral endplate, is one of the most common pathological triggers of acute and chronic low back pain, significantly depreciating an individual's quality of life and instigating huge socioeconomic costs. Novel emerging therapeutic techniques are hence of great interest to both research and clinical communities alike. Exogenous crosslinking, such as Genipin, and platelet-rich plasma therapies have been recently demonstrated encouraging results for the repair and regeneration of degenerated discs, but there remains a knowledge gap regarding the quantitative degree of effectiveness and particular influence on the mechanical properties of the disc...
December 1, 2016: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28018762/biological-treatment-approaches-for-degenerative-disc-disease-a-review-of-clinical-trials-and-future-directions
#17
REVIEW
Brenton Pennicooke, Yu Moriguchi, Ibrahim Hussain, Lawrence Bonssar, Roger Härtl
Biologic-based treatment strategies for musculoskeletal diseases have gained traction over the past 20 years as alternatives to invasive, costly, and complicated surgical interventions. Spinal degenerative disc disease (DDD) is among the anatomic areas being investigated among this group, notably due to its high incidence and functional debilitation. In this review, we report the literature encompassing the use of biologic-based therapies for DDD. Articles published between January 1995 and November 2015 were reviewed, with a subset meeting the primary and secondary inclusion criteria of clinical trial results that could be sub-classified into bimolecular, cell-based, or gene therapies, as well as studies investigating the utility of allogeneic and tissue-engineered intervertebral discs...
November 22, 2016: Curēus
https://www.readbyqxmd.com/read/28017756/a-clinical-comparison-of-anterior-cervical-plates-versus-stand-alone-intervertebral-fusion-devices-for-single-level-anterior-cervical-discectomy-and-fusion-procedures
#18
Ripul R Panchal, Kee D Kim, Robert Eastlack, John Lopez, Andrew Clavenna, Daina M Brooks, Gita Joshua
OBJECTIVE: To compare radiologic and clinical outcomes, including rates of dysphagia and dysphonia, using a no-profile stand-alone intervertebral spacer with integrated screw fixation versus an anterior cervical plate and spacer construct for single-level anterior cervical discectomy and fusion (ACDF) procedures. METHODS: This multicenter, randomized, prospective study included 54 patients with degenerative disc disease (DDD) requiring ACDF at a single level at C3-C7...
December 22, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28012080/three-dimensional-micro-computed-tomography-analysis-for-spinal-instability-after-lumbar-facetectomy-in-the-rat
#19
Daisuke Fukui, Mamoru Kawakami, Kevin Cheng, Koichiro Murata, Keianne Yamada, Rinoka Sato, Munehito Yoshida, Hiroshi Yamada, Nozomu Inoue, Koichi Masuda
PURPOSE: Intervertebral disc degeneration is thought to contribute to low back pain. However, the pathophysiological mechanisms remain controversial. In a previous study, we developed an animal model that showed delayed gait disturbance after lumbar facetectomy in the rat. We believe that this gait disturbance was caused by low back pain, although the mechanisms of this gait abnormality remain unknown. The purpose of this study was to evaluate structural changes of the lumbar spine after facetectomy in the rat utilizing three-dimensional micro-computed tomography (3DμCT) compared to histology...
December 23, 2016: European Spine Journal
https://www.readbyqxmd.com/read/28002916/mesenchymal-stem-cells-for-intervertebral-disc-regeneration
#20
G Vadalà, F Russo, L Ambrosio, R Papalia, V Denaro
Low back pain (LBP) is one of the most common disabling symptoms affecting the adult population throughout the industrialized world. The main cause underlying this condition is intervertebral disc degeneration (IDD), which is characterized by progressive decrease of the proteoglycan content within the nucleus pulposus (NP), leading to disc dehydration and loss of its morpho-functional and biomechanical properties. To date, LBP treatment is based upon conservative and invasive procedures which are not capable of restoring the degenerative alterations of the disc, as they only help relieve the symptoms and/or slow down disc degeneration and are, nonetheless, characterized by significant comorbidities, costs and secondary risks...
October 2016: Journal of Biological Regulators and Homeostatic Agents
keyword
keyword
39158
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"