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https://www.readbyqxmd.com/read/28538779/sweat-test-and-cystic-fibrosis-overview-of-test-performance-at-public-and-private-centers-in-the-state-of-s%C3%A3-o-paulo-brazil
#1
Maria Fátima Servidoni, Carla Cristina Souza Gomez, Fernando Augusto Lima Marson, Adyléia Aparecida Dalbo Contrera Toro, Maria Ângela Gonçalves de Oliveira Ribeiro, José Dirceu Ribeiro, Antônio Fernando Ribeiro
Objective: The sweat test (ST) measures chloride levels in sweat and is considered the gold standard for the diagnosis of cystic fibrosis (CF). However, the reliability of a ST depends on their being performed by experienced technicians and in accordance with strict guidelines. Our aim was to evaluate how sweat stimulation, sweat collection, and chloride measurement are performed at 14 centers (9 public centers and 5 private centers) that routinely perform STs in the state of São Paulo, which has the highest frequency of CF in Brazil...
March 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28538507/female-sex-bilateral-disease-age-below-3-years-and-apprehension-for-enucleation-contribute-to-treatment-abandonment-in-retinoblastoma
#2
Anish Bhargav, Usha Singh, Amita Trehan, Zoramathara Zadeng, Deepak Bansal
Treatment abandonment is a major obstacle for treating retinoblastoma in developing countries. The aim was to evaluate plausible causes, outcome, and rate of treatment abandonment in patients with retinoblastoma. The study was retrospective and conducted in a University hospital in North-India. Two cohorts of patients were studied. One was a larger cohort (n=602) of all patients with retinoblastoma in the institution from 2000 to 2014. Limited variables (age, sex, and laterality) were examined in this cohort due to incomplete data/lack of contact...
May 22, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28538459/patient-comprehension-and-compliance-survey-to-assess-postoperative-pain-regimens-in-the-orthopaedic-trauma-population
#3
Anup K Gangavalli, Ajith Malige, Saqib Rehman, Chinenye O Nwachuku
OBJECTIVE: This study aims to determine the groups of patients who are at risk for noncompliance and misunderstanding of their pain regimen. DESIGN: Survey-based cohort study. SETTING: Suburban Level-I trauma center. PATIENTS/PARTICIPANTS: A total of 171 patients between the ages of 18-89 years who underwent surgical fixation of fractures involving the pelvis, long bones, or periarticular regions of the knee, ankle, elbow, and wrist...
June 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28534175/-aseptic-loosening-of-total-ankle-replacement-two-stage-revision-with-bone-augmentation-of-osseous-defects-and-secondary-prosthesis-implantation
#4
A Barg, M Wiewiorski, V Valderrabano
OBJECTIVE: To remove loosened ankle prosthesis components, perform osseous defect augmentation, and reimplant definitive prosthesis components to preserve ankle range of motion. INDICATIONS: Aseptic loosening of the tibial and/or talar ankle prosthesis components with substantial bone defect. CONTRAINDICATIONS: General surgical/anesthesiological risks, infections, critical soft tissue conditions, nonmanageable hindfoot instability, neurovascular impairment of the lower extremity, neuroarthropathy, substantial nonreconstructable osseous defects with or without cysts on the tibial and/or talar side, noncompliance, primary total ankle replacement (TAR) using intramedullary fixation (stem fixation), severely reduced bone quality, insulin-dependent diabetes mellitus, smoking, unrealistic patients' expectations, high activity in sports...
May 22, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28532461/national-post-market-surveillance-assessment-of-veterinary-medicines-in-korea-during-the-past-decade
#5
JeongWoo Kang, Hae-Chul Park, Yang Ho Jang, Md Akil Hossain, Kyunghun Jeong, Mi Young Jeong, Seon-Jong Yun, Sung-Won Park, Dae Gyun Kim, Kwang-Jick Lee
BACKGROUND: Veterinary medicines have been widely used for the prevention and treatment of diseases, growth promotion, and to promote feeding efficacy in livestock. As the veterinary medicine industry has steadily grown, it is crucial to set up a baseline for the quality of medicine as well as the insufficiency or excessiveness of the active ingredients in drug products to ensure the compliance, safety and efficacy of these medicines. Thus, the 10 years data of post-marketing quality control study was summarized to determine the rate and extent of non-compliance of these medicines and to establish baseline data for future quality control measures of veterinary medicine...
May 22, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28531119/quality-attributes-and-in-vitro-bioequivalence-of-different-brands-of-amoxicillin-trihydrate-tablets
#6
Moawia M Al-Tabakha, Khairi M S Fahelelbom, Dana Emad Eddin Obaid, Sadik Sayed
Bacterial resistance and antibiotic drug effectiveness can be related to administering generic products with a subtherapeutic dose or poor in vivo drug release. The aim of this study was to investigate whether locally marketed amoxicillin tablets have the required chemical and physical attributes, including in vitro bioequivalence performance. Five generic products (T1, T2, T3, T4, and T5) containing combination of amoxicillin trihydrate and potassium clavulanate as 1 g strength present in immediate release tablets were compared to the reference listed drug product Augmentin® (R) for weight variation, friability, resistance to crushing, and chemical content of amoxicillin...
May 20, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28529363/treatment-compliance-and-noncompliance-in-psychoses
#7
K Nagaraja Rao, Jitty George, C Y Sudarshan, Shamshad Begum
BACKGROUND: Compliance or noncompliance with treatment significantly influences course and outcome of psychiatric disorders. While noncompliance has been extensively researched, compliance has received less attention. The current study was conducted to elicit reasons for compliance and noncompliance in patients having psychoses attending psychiatric clinics. MATERIALS AND METHODS: A total of 196 compliant and 150 noncompliant patients were interviewed using self-designed tools to elicit sociodemographic data, details of illness, and treatment...
January 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28526312/identification-of-low-high-and-super-gelers-and-barriers-to-hand-hygiene-among-intensive-care-unit-nurses
#8
Sharon Lea Kurtz
BACKGROUND: The purpose of this article was to provide information identified during hand hygiene (HH) surveillance periods at 5 intensive care units (ICUs) (4 hospitals) in Texas. METHODS: Using room entry and room exit, overt observation periods were 8 consecutive hours for 3-5 days on 64 ICU nurses. RESULTS: A total of 3,620 HH opportunities were recorded during 18 days of observation (144 hours). The average hand hygiene compliance (HHC) rate was 64%, with 19% of the nurses participating in HH in the 60%-69% range...
May 16, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28511684/access-to-pediatric-rheumatology-care-for-juvenile-idiopathic-arthritis-in-the-united-arab-emirates
#9
Khulood Khawaja, Mustafa Al-Maini
BACKGROUND: This study looks at access to care for Juvenile Idiopathic Arthritis through pediatric rheumatology in the UAE, as an example of multi-ethnic society. METHODS: Patients with a diagnosis of Juvenile idiopathic arthritis were identified through the hospital electronic medical records system from January 1st 2011 to December 31st 2014. All residents of the United Arab Emirates hold an Emirates identity card. We divided our patients into two groups: Emirati-Emirates, who are native Emirati children and hold the Emirati nationality, as stated on their Emirates identity card, and who therefore have full, comprehensive access to free medical care; and non-Emirati-Emirates, who represent other nationalities, as stated on their Emirates identity card...
May 16, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28509573/adverse-events-of-atomoxetine-in-a-double-blind-placebo-controlled-study-in-children-with-autism
#10
Rameshwari V Tumuluru, Patricia Corbett-Dick, Michael G Aman, Tristram Smith, L Eugene Arnold, Xueliang Pan, Kristin A Buchan-Page, Nicole V Brown, Melissa M Ryan, Susan L Hyman, Jessica Hellings, Craig Williams, Jill A Hollway, Luc Lecavalier, Robert R Rice, Sarah McAuliffe-Bellin, Benjamin L Handen
OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) symptoms, including inattention and over activity, occur in approximately one-third of children with autism spectrum disorder (ASD). We describe the rate and duration of adverse events in a randomized controlled trial of atomoxetine (ATX) and parent training (PT) for ADHD symptoms and noncompliance in children with ASD. METHODS: We conducted a 10-week, double-blind, 2 × 2 trial of ATX and PT with 128 children (ages 5-14) randomized to ATX alone, ATX+PT, placebo+PT, or placebo alone...
May 16, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28499697/assessment-of-dietary-compliance-in-celiac-children-using-a-standardized-dietary-interview
#11
Margaretha M S Wessels, Marije Te Lintelo, Sabine L Vriezinga, Hein Putter, Erica G Hopman, M Luisa Mearin
BACKGROUND & AIMS: Compliance to a gluten free diet (GFD) in celiac disease (CD) is ideally assessed by dietary interviews, albeit time-consuming. Short dietary questionnaires have been developed for adults but not for children. Primary aim was to compare GFD compliance in celiac children, measured by a short dietary questionnaire against a dietary interview. Secondary aims were correlation between both questionnaires and celiac antibodies and identifying variables predicting noncompliance...
April 17, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28497448/healing-of-spongiosus-cutaneous-fistula-with-hyperbaric-oxygen-therapy-hbot-a-case-report
#12
Pier A Della Camera, Gianmartin Cito, Simone Morselli, Francesco Sessa, Davide Facchiano, Andrea Cocci, Mauro Gacci, Sergio Serni, Marco Carini, Alessandro Natali
INTRODUCTION: We present a case of a spongiosus-cutaneous fistula in a 39-year-old man with recurrent episodes of cutaneous abscess in dorsal middle third penis (5 × 3 cm) treated with Hyperbaric Oxygen Therapy (HBOT). CASE REPORT: After emptying nodular abscess, the patient was noncompliant for further surgery. Therefore, it was suggested the association between HBOT and antibiotic therapy. HBOT is carried out in a hyperbaric room, where the internal pressure is increased (compression phase) by entering compressed air up to 283...
May 10, 2017: Urologia
https://www.readbyqxmd.com/read/28482854/medical-decision-making-in-children-and-adolescents-developmental-and-neuroscientific-aspects
#13
REVIEW
Petronella Grootens-Wiegers, Irma M Hein, Jos M van den Broek, Martine C de Vries
BACKGROUND: Various international laws and guidelines stress the importance of respecting the developing autonomy of children and involving minors in decision-making regarding treatment and research participation. However, no universal agreement exists as to at what age minors should be deemed decision-making competent. Minors of the same age may show different levels of maturity. In addition, patients deemed rational conversation-partners as a child can suddenly become noncompliant as an adolescent...
May 8, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28473100/coronary-artery-calcification-from-mechanism-to-molecular-imaging
#14
REVIEW
Takehiro Nakahara, Marc R Dweck, Navneet Narula, David Pisapia, Jagat Narula, H William Strauss
Vascular calcification is a hallmark of atherosclerosis. The location, density, and confluence of calcification may change portions of the arterial conduit to a noncompliant structure. Calcifications may also seed the cap of a thin cap fibroatheroma, altering tensile forces on the cap and rendering the lesion prone to rupture. Many local and systemic factors participate in this process, including hyperlipidemia, ongoing inflammation, large necrotic cores, and diabetes. Vascular cells can undergo chondrogenic or osteogenic differentiation, causing mineralization of membranous bone and formation of endochondral bone...
May 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28463161/feasibility-of-patient-reporting-of-symptomatic-adverse-events-via-the-patient-reported-outcomes-version-of-the-common-terminology-criteria-for-adverse-events-pro-ctcae-in-a-chemoradiotherapy-cooperative-group-multicenter-clinical-trial
#15
Ethan Basch, Stephanie L Pugh, Amylou C Dueck, Sandra A Mitchell, Lawrence Berk, Shannon Fogh, Lauren J Rogak, Marcha Gatewood, Bryce B Reeve, Tito R Mendoza, Ann M O'Mara, Andrea M Denicoff, Lori M Minasian, Antonia V Bennett, Ann Setser, Deborah Schrag, Kevin Roof, Joan K Moore, Thomas Gergel, Kevin Stephans, Andreas Rimner, Albert DeNittis, Deborah Watkins Bruner
PURPOSE: To assess the feasibility of measuring symptomatic adverse events (AEs) in a multicenter clinical trial using the National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). METHODS AND MATERIALS: Patients enrolled in NRG Oncology's RTOG 1012 (Prophylactic Manuka Honey for Reduction of Chemoradiation Induced Esophagitis-Related Pain during Treatment of Lung Cancer) were asked to self-report 53 PRO-CTCAE items representing 30 symptomatic AEs at 6 time points (baseline; weekly ×4 during treatment; 12 weeks after treatment)...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28462388/multidimensional-assessment-of-challenging-behaviors-in-advanced-stages-of-dementia-in-nursing-homes-the-insidedem-framework
#16
Stefan Teipel, Christina Heine, Albert Hein, Frank Krüger, Andreas Kutschke, Sven Kernebeck, Margareta Halek, Sebastian Bader, Thomas Kirste
INTRODUCTION: Assessment of challenging behaviors in dementia is important for intervention selection. Here, we describe the technical and experimental setup and the feasibility of long-term multidimensional behavior assessment of people with dementia living in nursing homes. METHODS: We conducted 4 weeks of multimodal sensor assessment together with real-time observation of 17 residents with moderate to very severe dementia in two nursing care units. Nursing staff received extensive training on device handling and measurement procedures...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28458993/chromoblastomycosis-caused-by-rhinocladiella-similis-case-report
#17
Daiane Heidrich, Gloria M González, Danielle M Pagani, Mauricio Ramírez-Castrillón, Maria Lucia Scroferneker
We report a case of chromoblastomycosis in lesions on the chest and foot. Itraconazole was chosen as the initial treatment for this patient, who was followed up for 8 months before becoming noncompliant. The pathogenic fungal species was identified as Rhinocladiella similis by ITS region sequencing. In vitro analyses indicate that the fungus was sensitive to posaconazole and itraconazole. This report presents R. similis as a new agent of chromoblastomycosis and raises the hypothesis that this species could be more resistant to some antifungals than R...
June 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28458432/rational-drug-therapy-education-in-clinical-phase-carried-out-by-task-based-learning
#18
S Sırrı Bilge, Bahar Akyüz, Arzu Erdal Ağrı, Mıdık Özlem
OBJECTIVES: Irrational drug use results in drug interactions, treatment noncompliance, and drug resistance. Rational pharmacotherapy education is being implemented in many faculties of medicine. Our aim is to introduce rational pharmacotherapy education by clinicians and to evaluate task-based rational drug therapy education in the clinical context. METHODS: The Kirkpatrick's evaluation model was used for the evaluation of the program. The participants evaluated the program in terms of constituents of the program, utilization, and contribution to learning...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28458073/community-directed-mass-drug-administration-is-undermined-by-status-seeking-in-friendship-networks-and-inadequate-trust-in-health-advice-networks
#19
Goylette F Chami, Andreas A Kontoleon, Erwin Bulte, Alan Fenwick, Narcis B Kabatereine, Edridah M Tukahebwa, David W Dunne
Over 1.9 billion individuals require preventive chemotherapy through mass drug administration (MDA). Community-directed MDA relies on volunteer community medicine distributors (CMDs) and their achievement of high coverage and compliance. Yet, it is unknown if village social networks influence effective MDA implementation by CMDs. In Mayuge District, Uganda, census-style surveys were conducted for 16,357 individuals from 3,491 households in 17 villages. Praziquantel, albendazole, and ivermectin were administered for one month in community-directed MDA to treat Schistosoma mansoni, hookworm, and lymphatic filariasis...
June 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28453113/loss-to-follow-up-in-tuberculosis-treatment-and-its-relationship-with-patients-knowledge-of-the-disease-and-other-associated-factors
#20
Aylana De S Belchior, Evelyne Marie T Mainbourg, Maria J Ferreira-Gonçalves
Objective: To identify factors associated with loss to follow-up in Tuberculosis (TB) treatment, including patients' level of knowledge regarding treatment of this disease. Methods: 42 loss to follow-up cases and 84 control cases that were finishing the sixth month of their first treatment for tuberculosis were selected for this study. Primary data were gathered through interviews, while secondary data were obtained from the notification form of the disease, between December 2011 and April 2012...
September 2016: Revista de Salud Pública
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