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https://www.readbyqxmd.com/read/29241139/mussels-and-clams-from-the-italian-fish-market-is-there-a-human-exposition-risk-to-metals-and-arsenic
#1
L M Chiesa, F Ceriani, M Caligara, D Di Candia, R Malandra, S Panseri, F Arioli
Seafood is associated with many beneficial effects on human health. However, the overall level of contaminants in biota has increased over the last two centuries and seafood is one of the source of oral exposition to contaminants. Therefore, this work aimed to evaluate cadmium, lead, mercury, arsenic, chromium and nickel presence in mussels and clams, from the Italian market, and the associated risk. The samples were from five different FAO areas. Analyses were carried out using inductively-coupled plasms-mass spectrometry...
December 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/29239086/treatment-of-pathologic-peri-implant-pockets
#2
REVIEW
Stefan Renvert, Ioannis Polyzois
Peri-implant and periodontal pockets share a number of anatomical features but also have distinct differences. These differences make peri-implant pockets more susceptible to trauma and infection than periodontal pockets. Inadequate maintenance can lead to infections (defined as peri-implant mucositis and peri-implantitis) within peri-implant pockets. These infections are recognized as inflammatory diseases, which ultimately lead to the loss of supporting bone. Diagnostic and treatment methods conventionally used in periodontics have been adopted to assess and treat these diseases...
February 2018: Periodontology 2000
https://www.readbyqxmd.com/read/29239026/early-cutaneous-eruptions-after-oral-hydroxychloroquine-in-a-lupus-erythematosus-patient-a-case-report-and-review-of-the-published-work
#3
Tomoko Matsuda, Nhung Thi My Ly, Naotomo Kambe, Chuyen Thi Hong Nguyen, Ikuko Ueda-Hayakawa, Yonsu Son, Hiroyuki Okamoto
Hydroxychloroquine (HCQ) is an effective treatment of lupus erythematosus. Although adverse effects, mainly gastrointestinal and cutaneous manifestations, are rare, they may result in the cessation of medication in some patients with severe reactions. Therefore, the evaluation of a patient's condition is important for a dermatologist to decide whether to cease or continue HCQ. We herein report a case of a 36-year-old Japanese woman with systemic lupus erythematosus and cutaneous eruptions caused by the p.o...
December 14, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29238412/oral-leiomyoma-in-an-adult-male-a-case-report
#4
Amanda Phoon Nguyen, Agnieszka M Frydrych
Introduction: Oral leiomyomas are rare, benign neoplasms of smooth muscle origin, presenting as a solitary, asymptomatic, nodular mass. Case Presentation: Here we present the case of a 54-year-old male with a lesion in the midline of his hard palate, which was diagnosed as a localized benign leiomyoma, along with a review of the recent literature. Discussion: Diagnosis of a leiomyoma must be based on the histopathological assessment of tissue as the clinical appearance is non-specific...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/29238162/rapid-resolution-of-toxoplasma-chorioretinitis-treatment-using-quadruple-therapy
#5
Arief Kartasasmita, Wendy P Muntur, Sutarya Enus, Erwin Iskandar
Purpose: To compare the effectiveness of quadruple-drug therapy consisting of cotrimoxazole (trimethopin and sulfamethoxazole), clindamycin antibiotics, and oral corticosteroid versus triple therapy consisting of pyrimetamine, sulphadiazine, and oral corticosteroid in the resolution of toxoplasmic chorioretinitis. Methods: This was a double-blind randomized controlled trial with repeated measures using parallel design to compare the effectiveness of quadruple-drug therapy and triple-drug therapy in patients with toxoplasmic chorioretinitis...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29237960/spritzer-for-diagnostic-cytopathology
#6
Rashmi Metgud, Smitha Naik, Shrikant Patel
BACKGROUND: Exfoliative cytology is an easy, economical, noninvasive, and feasible method for early detection and screening program of any premalignant or malignant lesion. In case of routine cytological procedure, classical Papanicolaou (PAP) stain is widely used while Romanowsky stains are sparingly used. Leishman-Giemsa (LG) cocktail, being a easier, cost effective staining technique, has not been used in exfoliative cytology. Therefore, this pilot study was carried out to compare and contrast the role of LG stain in routine cytological procedure which is very cost-effective, less time-consuming and requires less infrastructural support...
October 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29237707/buruli-ulcer-a-prototype-for-ecosystem-related-infection-caused-by-mycobacterium-ulcerans
#7
REVIEW
Dezemon Zingue, Amar Bouam, Roger B D Tian, Michel Drancourt
Buruli ulcer is a noncontagious disabling cutaneous and subcutaneous mycobacteriosis reported by 33 countries in Africa, Asia, Oceania, and South America. The causative agent, Mycobacterium ulcerans, derives from Mycobacterium marinum by genomic reduction and acquisition of a plasmid-borne, nonribosomal cytotoxin mycolactone, the major virulence factor. M. ulcerans-specific sequences have been readily detected in aquatic environments in food chains involving small mammals. Skin contamination combined with any type of puncture, including insect bites, is the most plausible route of transmission, and skin temperature of <30°C significantly correlates with the topography of lesions...
January 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29237661/exophytic-cystic-liver-lesion-an-unusual-presentation-of-a-hepatocellular-carcinoma-in-a-young-female
#8
Thomas Gardiner, David Nasralla, Eve Fryer, Helen Bungay, Michael Silva
Hepatocellular carcinoma (HCC) is one of the most common malignant primary liver tumours. However, primary hepatic carcinomas are rare in young adults, accounting for approximately 1% of tumours in people below the age of 20. Hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are the two most important aetiological agents of HCC. The average age at onset of HBV-related HCC (~50 years old) is 10 years younger than that of HCV-related HCC (61-64 years). Evidence for an association between the oral contraceptive pill (OCP) and development of HCC remains inconclusive...
December 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29237244/in-silico-analysis-of-the-competition-between-streptococcus-sanguinis-and-streptococcus-mutans-in-the-dental-biofilm
#9
Braulio Valdebenito, P Omar Tullume-Vergara, Wendy González, Jens Kreth, Rodrigo A Giacaman
During dental caries, the dental biofilm modifies the composition of the hundreds of involved bacterial species. Changing environmental conditions predisposes competition. A pertinent model to exemplify the complex interplay of the microorganisms in the human dental biofilm is the competition between Streptococcus sanguinis (S. sanguinis) and Streptococcus mutans (S. mutans). It has been reported that children and adults harbor greater numbers of S. sanguinis in the oral cavity, associated with carious-free teeth...
December 13, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/29234364/eghb010-a-standardized-extract-of-paeoniae-radix-and-glycyrrhizae-radix-inhibits-vegf-induced-tube-formation-in-vitro-and-retinal-vascular-leakage-and-choroidal-neovascularization-in-vivo
#10
Eunsoo Jung, Wookwon Jung, Su-Bin Park, Chan-Sik Kim, Jin Sook Kim, Junghyun Kim
EGHB010 is a hot water extract of the rhizome mixture of Paeonia lactiflora Pallas and Glycyrrhiza uralensis Fisch. Choroidal neovascularization (CNV) and vascular leakage are the common pathophysiologies of age-related macular degeneration. In this study, we aimed to evaluate the effect of EGHB010 on retinal vascular leakage and laser-induced CNV in a rat model. Vascular endothelial growth factor- (VEGF-) induced tube formation was assayed in human retinal microvascular endothelial cells. Intravitreal VEGF-induced blood-retinal barrier breakdown was assayed in Sprague-Dawley rats...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29233733/regulation-mechanism-of-dioscin-on-uric-acid-excretion
#11
Yi Zhang, Lijun Jin, Jinchang Liu, Wei Wang, Haiyang Yu, Jian Li, Qian Chen, Tao Wang
ETHNOPHARMACOLOGY RELEVANCE: Dioscin, a spirostane glycoside, the rhizoma of Dioscorea septemloba (Diocoreacea) is used for diuresis, rheumatism, and joints pain. Given the poor solubility and stability of Dioscin, we proposed a hypothesis that Dioscin's metabolite(s) are the active substance(s) in vivo to contribute to the reducing effects on serum uric acid levels. AIM OF THE STUDY: The aim of this study is to identify the active metabolite(s) of Dioscin in vivo and to explore the mechanism of its antihyperuricemic activity...
December 9, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29230499/-fulminant-sepsis-after-capnocytophaga-canimorsus-infection
#12
K Feige, Pia Hartmann, J T Lutz
Capnocytophaga canimorsus is a Gram-negative bacterium present in the oral cavities of cats and dogs. It is known for its capability to cause life-threatening sepsis following a dog bite, especially in immunocompromised patients. We report the case of a 67-year-old man who suffered from septic shock and multiorgan failure presumably following contamination of a pre-existing minor skin lesion by canine saliva. The purpose of this report is to raise awareness of Capnocytophaga canimorsus among physicians when faced with a patient presenting with fulminant septic shock and Gram-negative bacteremia, who has been exposed to dogs...
December 11, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/29230387/hyperpigmentation-of-the-hard-palate-mucosa-in-a-patient-with-chronic-myeloid-leukaemia-taking-imatinib
#13
Gian Paolo Bombeccari, Umberto Garagiola, Francesco Pallotti, Margherita Rossi, Massimo Porrini, Aldo Bruno Giannì, Francesco Spadari
Background: Imatinib mesylate is an inhibitor of the tyrosine kinase Bcr-Abl and a first-line treatment for Philadelphia chromosome-positive chronic myeloid leukaemia (CML). Dermatological side effects include superficial oedema, pustular eruption, lichenoid reactions, erythroderma, and skin rash. Depigmentation of the skin and/or mucosa is uncommon, and hyperpigmentation is rare. Case presentation: We present the case of a 63-year-old Caucasian male with widespread hyperpigmentation of the hard palate associated with a 9-year history of imatinib therapy to treat CML...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29228568/sitagliptin-and-oral-cancer-risk-in-type-2-diabetes-patients
#14
Chin-Hsiao Tseng
The reimbursement database of the Taiwan's National Health Insurance was used to evaluate oral cancer risk after sitagliptin use. Patients newly diagnosed of type 2 diabetes during 1999-2008 were recruited. A 1:1 propensity score matched-pair sample of 39195 ever users and 39195 never users were followed up until December 31, 2011. Cox regression incorporated with the inverse probability of treatment weighting using propensity score was used to estimate hazard ratios. Results showed that the overall hazard ratio was not statistically significant (0...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228383/oral-fungal-bacterial-biofilm-models-in-vitro-a-review
#15
Marlene Chevalier, Stephane Ranque, Isabelle Prêcheur
Inclusion of fungi as commensals in oral biofilm is an important innovation in oral biology, and this work aimed to review the literature on the available biofilm and related disease in vitro models. Actually, thousands of bacterial and around one hundred of fungal phylotypes can colonize the oral cavity. Taxonomic profiling combined with functional expression analysis has revealed that Candida albicans, Streptococcus mutans and prominent periodontopathogens are not always present or numerically important in candidiasis, caries, or periodontitis lesions...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29227715/human-papillomavirus-genome-integration-and-head-and-neck-cancer
#16
L M Pinatti, H M Walline, T E Carey
We conducted a critical review of human papillomavirus (HPV) integration into the host genome in oral/oropharyngeal cancer, reviewed the literature for HPV-induced cancers, and obtained current data for HPV-related oral and oropharyngeal cancers. In addition, we performed studies to identify HPV integration sites and the relationship of integration to viral-host fusion transcripts and whether integration is required for HPV-associated oncogenesis. Viral integration of HPV into the host genome is not required for the viral life cycle and might not be necessary for cellular transformation, yet HPV integration is frequently reported in cervical and head and neck cancer specimens...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29225365/a-review-of-the-effectiveness-and-side-effects-of-fluocinolone-acetonide-0-1-in-the-treatment-of-oral-mucosal-diseases
#17
REVIEW
Kobkan Thongprasom
Topical steroids have been widely used in the treatment of symptomatic oral lesions to reduce pain and inflammation. Potent topical steroids such as clobetasol propionate, fluocinolone acetonide (FA), and fluocinonide have been widely used in the treatment of severe oral mucosal lesions. Many reports have demonstrated that these steroids were effective in treating oral lesions with only minor side-effects. This review describes the effectiveness and side-effects of using FA 0.1% in the treatment of symptomatic oral lichen planus (OLP), oral lichenoid drug reaction (OLDR), oral pemphigus, and herpes associated erythema multiforme (HAEM)...
September 2017: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/29225245/oral-methotrexate-related-lymphoproliferative-disease-presenting-with-severe-osteonecrosis-of-the-jaw-a-case-report-and-literature-review
#18
Sachiko Furukawa, Kazunari Oobu, Masafumi Moriyama, Shintaro Kawano, Saori Sako, Jun-Nosuke Hayashida, Ryota Matsubara, Ken-Ichi Ogata, Tamotsu Kiyoshima, Seiji Nakamura
Long-term methotrexate (MTX) treatment can cause MTX-related lymphoproliferative disorder (MTX-LPD). We experienced a case of MTX-LPD that was associated with severe osteonecrosis of the jaw mimicking medication-related osteonecrosis of the jaw. The patient was an 81-year-old woman with rheumatoid arthritis (RA) who was treated with MTX and bisphosphonate. After 7 years, she was referred to our department for the assessment of giant ulcer and exposure of the alveolar bone of the left maxilla. Histopathological and immunological analyses confirmed a diagnosis of MTX-LPD...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29224826/evaluation-of-the-diagnostic-efficacy-and-spectrum-of-autofluorescence-of-benign-dysplastic-and-malignant-lesions-of-the-oral-cavity-using-velscope
#19
Ravikant S Ganga, Dipali Gundre, Shivani Bansal, Pankaj M Shirsat, Pooja Prasad, Rajiv S Desai
OBJECTIVES: Conventional oral examination and biopsy are the only reliable methods for the early detection of oral cancer at present. Autofluorescence examination of oral tissues using the VELscope has been suggested as an adjunctive tool for cancer detection and diagnosis. The aim of our study was to evaluate the efficacy of the VELscope in recognizing dysplastic and/or neoplastic changes in oral mucosal lesions that were identified on conventional oral examination. MATERIALS AND METHODS: Two hundred patients with oral mucosal lesions were subjected to conventional oral examination followed by VELscope examination and their autofluorescence characteristics were compared with the histopathological diagnosis...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29224821/a-multicenter-study-of-malignant-oral-and-maxillofacial-lesions-in-children-and-adolescents
#20
José Alcides Almeida de Arruda, Leni Verônica de Oliveira Silva, Camila de Nazaré Alves de Oliveira Kato, Lauren Frenzel Schuch, Aline Carvalho Batista, Nádia Lago Costa, Sandra Beatriz Chaves Tarquinio, Elena Riet Correa Rivero, Vinícius Coelho Carrard, Manoela Domingues Martins, Ana Paula Veras Sobral, Ricardo Alves Mesquita
OBJECTIVES: To investigate the frequency of malignant oral and maxillofacial lesions among children and adolescents from representative geographic regions of Brazil. MATERIALS AND METHODS: A retrospective study was conducted on biopsies obtained from 1990 to 2016 at six Brazilian oral and maxillofacial pathology referral centers. A total of 85,105 biopsy specimens from children and adolescents were analyzed. Gender, age, anatomical location, symptomatology and histopathological diagnosis were evaluated...
December 2017: Oral Oncology
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