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https://www.readbyqxmd.com/read/28545132/proteomics-investigation-of-oscc-specific-salivary-biomarkers-in-a-hungarian-population-highlights-the-importance-of-identification-of-population-tailored-biomarkers
#1
Éva Csősz, Péter Lábiscsák, Gergő Kalló, Bernadett Márkus, Miklós Emri, Adrienn Szabó, Ildikó Tar, József Tőzsér, Csongor Kiss, Ildikó Márton
Oral squamous cell carcinoma (OSCC) accounting for about 90% of malignant oral lesions is the 6th most common malignancy worldwide. Diagnostic delay may contribute to dismal survival rate therefore, there is a need for developing specific and sensitive biomarkers to improve early detection. Hungarian population occupies the top places of statistics regarding OSCC incidence and mortality figures therefore, we aimed at finding potential salivary protein biomarkers suitable for the Hungarian population. In this study we investigated 14 proteins which were previously reported as significantly elevated in saliva of patients with OSCC...
2017: PloS One
https://www.readbyqxmd.com/read/28543730/treatment-of-disseminated-superficial-actinic-porokeratosis-with-oral-alitretinoin
#2
B J Park, E H Oh, J E Kim, J Y Ko, Y S Ro
Disseminated superficial actinic porokeratosis (DSAP), the most common type of porokeratosis, usually presents as large numbers of lesions on sun-exposed skin. Although several treatment options including corticosteroids, keratolytics, 5-fluorouracil, imiquimod, vitamin D3 analogues, cryotherapy, curettage, laser therapy and dermabrasion may be considered, there is no evidence-based standard treatment.(1-2) Patient 1 was a 26-year-old female who presented with a 2-year history of progressive scaly macules on both upper and lower extremities...
May 22, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28543379/idiopathic-lymphoplasmacellular-mucositis-of-the-lips-a-case-report-and-review-of-the-literature
#3
Ren-Feng Liu, Chun-Bing Chen, Tseng-Tong Kuo, Wen-Hung Chung
Idiopathic lymphoplasmacellular mucositis (ILPM) is a group of disorders histologically characterized by dense infiltrates of lymphocytes and plasma cells in submucosa. These lesions are initially observed on the glans penis and vulva, and later on buccal mucosa, lips, gingiva, tongue, epiglottis, larynx, and other mucosal surfaces have also been reported. We have reviewed the previously reported cases of ILPM with lip involvement, outlining the clinical presentation, treatment and outcome of the entity to date...
May 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28543318/correlation-between-salivary-and-serum-anti-desmoglein-1-and-3-antibody-titres-using-elisa-and-between-anti-desmoglein-levels-and-disease-severity-in-pemphigus-vulgaris
#4
D De, G Khullar, S Handa, N Joshi, B Saikia, R W Minz
ELISA for anti-desmoglein antibodies (Dsg) is commonly used for diagnosis and assessment of treatment response in pemphigus vulgaris (PV). The present study was conducted to assess the relationship between salivary and serum Dsg1 and Dsg3 levels, and whether salivary Dsg1 and Dsg3 levels correlate with clinical disease severity of oral mucosal lesions in PV. In total 43, patients with PV with predominantly mucosal involvement were recruited. Both serum and salivary samples were collected from the cases, and salivary samples were also collected from five controls...
May 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28542914/efficacy-and-adverse-events-of-oral-isotretinoin-for-acne-a-systematic-review
#5
REVIEW
I A Vallerand, R T Lewinson, M S Farris, C D Sibley, M L Ramien, A G M Bulloch, S B Patten
Despite many years of clinical use of isotretinoin, a comprehensive review of evidence for isotretinoin therapy in acne patients is lacking. We searched MEDLINE, EMBASE, Cochrane Central, relevant webpages and bibliographies for randomized controlled trials for acne evaluating isotretinoin vs control (placebo or other therapy). Data were extracted and summarized descriptively. Eleven trials were identified (total n=760 patients randomized), containing mostly males. Mean treatment ages ranged from 18 to 47.9 years and participants generally had moderate-severe acne...
May 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28542679/patterns-of-treatment-failure-and-postrecurrence-outcomes-among-patients-with-locally-advanced-head-and-neck-squamous-cell-carcinoma-after-chemoradiotherapy-using-modern-radiation-techniques
#6
Jonathan E Leeman, Jin-Gao Li, Xin Pei, Praveen Venigalla, Zachary S Zumsteg, Evangelia Katsoulakis, Eitan Lupovitch, Sean M McBride, Chiaojung J Tsai, Jay O Boyle, Benjamin R Roman, Luc G T Morris, Lara A Dunn, Eric J Sherman, Nancy Y Lee, Nadeem Riaz
Importance: Even though 15% to 50% of patients with head and neck squamous cell carcinoma (HNSCC) experience recurrence, relatively little is known regarding patterns of treatment failure and postrecurrence outcomes after chemoradiotherapy using modern radiation techniques (intensity-modulated radiotherapy [IMRT]). Recurrence patterns are significantly affected by variations in the quality of radiotherapy, which may confound findings from multicenter trials. Objective: To assess patterns of treatment failure and postrecurrence outcomes for patients with HNSCC treated with contemporary radiotherapy techniques...
May 25, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28542622/meta-analysis-of-magnetic-resonance-imaging-accuracy-for-diagnosis-of-oral-cancer
#7
Marcelo Aldrighi Moreira, Luiza Silveira Lessa, Francieli Regina Bortoli, Abigail Lopes, Eduardo Picolo Xavier, Renan Antonio Ceretta, Fernanda Guglielmi Faustini Sônego, Cristiane Damiani Tomasi, Patricia Duarte Simões Pires, Luciane Bisognin Ceretta, Ingrid Dalira Schweigert Perry, Priscyla Waleska Simões
OBJECTIVE: To establish the diagnostic accuracy of magnetic resonance imaging (MRI) as an auxiliary means for the diagnosis of oral cancer through a systematic review and meta-analysis. METHODS: An exhaustive search of publications from 1986 to 2016 was performed of Medline, Embase and Cochrane (and related databases), including grey literature. Primary diagnostic accuracy studies that assessed oral cancer (target condition) using MRI (index test) were included...
2017: PloS One
https://www.readbyqxmd.com/read/28542301/electronic-cigarette-aerosols-suppress-cellular-antioxidant-defenses-and-induce-significant-oxidative-dna-damage
#8
Vengatesh Ganapathy, Jimmy Manyanga, Lacy Brame, Dehra McGuire, Balaji Sadhasivam, Evan Floyd, David A Rubenstein, Ilangovan Ramachandran, Theodore Wagener, Lurdes Queimado
BACKGROUND: Electronic cigarette (EC) aerosols contain unique compounds in addition to toxicants and carcinogens traditionally found in tobacco smoke. Studies are warranted to understand the public health risks of ECs. OBJECTIVE: The aim of this study was to determine the genotoxicity and the mechanisms induced by EC aerosol extracts on human oral and lung epithelial cells. METHODS: Cells were exposed to EC aerosol or mainstream smoke extracts and DNA damage was measured using the primer anchored DNA damage detection assay (q-PADDA) and 8-oxo-dG ELISA assay...
2017: PloS One
https://www.readbyqxmd.com/read/28541872/chronic-paracoccidioidmycosis-in-a-woman-with-crohn-disease
#9
Harim Tavares Dos Santos, Bruno Augusto Benevenuto de Andrade, Darcy Fernandes, Daphine Caxias Travassos, Andreia Bufalino
We report a rare case of chronic paracoccidioidomycosis(PCM) in a woman with Crohn disease in the setting of treatment with azathioprine and mesalazine. Serum tests for antigens to Paracoccidioides brasiliensis, Histoplasma capsulatum, and Aspergillus fumigatus were negative. An incisional biopsy of an oral lesion with periodic acid-schiff and Grocott-methenamine silver stains revealed chronic granulomatous inflammation with multinucleated giant cells with Paracoccidioides brasiliensis within the cytoplasm, confirming the diagnosis of PCM...
April 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28540905/tuberous-sclerosis-complex-bourneville-pringle-disease-in-a-25-year-old-female-with-bilateral-renal-angiomyolipoma-and-secondary-hypertension
#10
Sahar El Aoud, Faten Frikha, Mouna Snoussi, Raida Ben Salah, Zouhir Bahloul
Tuberous sclerosis or tuberous sclerosis complex (TSC) is an autosomal dominant inherited neurocutaneous disorder that variably affects the brain, skin, kidneys, heart, and other organs. It is characterized by skin and renal lesions in addition to central and peripheral nervous system tumors, with neurological and psychiatric findings. We report such a rare case of tuberous sclerosis in a 25-year-old female who presented with abdominal pain and hypertension. Physical examination showed dermatological signs that included hypopigmented maculae, shagreen plaque, angiofibromas on the centrofacial areas, periungual fibromas on toes, and molluscum pendulum around the neck...
May 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28540669/tropical-enteropathies
#11
REVIEW
John Louis-Auguste, Paul Kelly
PURPOSE OF REVIEW: The term 'tropical enteropathy' originated in observations in the 1960s that small intestinal morphology and function differed in the tropics from the norms found in temperate climates. It was subsequently shown that this enteropathy is more closely related to environmental conditions than latitude, and it was re-labelled 'environmental enteropathy'. It is now recognised that environmental enteropathy (also now called environmental enteric dysfunction) has implications for the health and linear growth of children in low- and middle-income countries, and it may underlie poor responses to oral vaccination in these countries...
July 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28540615/clinical-evaluation-of-marketed-orthodontic-products-are-researchers-behind-the-times-a-meta-epidemiological-study
#12
Jadbinder Seehra, Nikolaos Pandis, Padhraig S Fleming
BACKGROUND: The role of marketing and industry in the treatment decisions of orthodontists has received increasing attention in recent years with clinical research typically undertaken subsequent to established use of these devices and often failing to confirm the promise of manufacturers' claims. This meta-epidemiological study was undertaken to assess the proportion of clinical trials in orthodontics evaluating commercially marketed products and to evaluate the direction of the results of these studies...
December 2017: Progress in Orthodontics
https://www.readbyqxmd.com/read/28540394/clinical-efficacy-of-a-two-year-oral-health-programme-for-infants-and-toddlers-in-singapore
#13
Bien Lai, Wee Kiat Tan, Qing Shu Lu
INTRODUCTION: Dental caries, which is prevalent in Singapore preschoolers, is a disease that has a major impact on children's health and places a high cost on the society and health services. Oral health programmes for young children implemented in several parts of the world have been shown to be effective in the prevention of dental caries. We aimed to examine the clinical efficacy of an oral health programme for infants and toddlers in Singapore. METHODS: 90 children and their caregivers participated in the programme while 64 children who were 24 months older than the intervention group at initial visit were recruited as controls in a quasi-experimental study design...
May 25, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28540347/interdisciplinary-management-of-head-and-neck-vascular-anomalies-clinical-presentation-diagnostic-findings-and-minimalinvasive-therapies
#14
REVIEW
Maliha Sadick, Walter A Wohlgemuth, Roland Huelse, Bettina Lange, Thomas Henzler, Stefan O Schoenberg, Haneen Sadick
OBJECTIVES: Vascular anomalies are included in the 30 000 rare diseases worldwide affecting less than 5/10 000 people. Depending on their morphology and biological properties, they can cause varied disorders with organ involvement. Almost 60% of vascular anomalies have a predilection for the head and neck region in children. Clinical and scientific effort to establish interdisciplinary management concepts for vascular anomalies is increasing worldwide. METHODS: Especially in the head and neck region, clinical impairment and organ dysfunction is associated with cosmetic issues that may represent a physical and psychological issue for the patient...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/28539985/oral-lichenoid-lesions-of-the-upper-lip
#15
Eleni A Georgakopoulou, Marina D Achtari
BACKGROUND: Oral lichen planus is a chronic inflammatory disease of unknown etiology. It is characterized by notable heterogeneity in clinical presentation and behavior. MAIN OBSERVATIONS: We describe 3 patients with lichenoid lesions of the upper lip and upper anterior gingiva. These cases probably represent a clinical subtype of lichenoid lesions associated with microbial antigenicity and are characterized by persistency. All three patients had a long history of previous ineffective treatments and all three showed an excellent response to a combination of clarithromycin (2 x 250 mg/day) and prednisolone (15 mg/day)...
March 31, 2017: Journal of Dermatological Case Reports
https://www.readbyqxmd.com/read/28539740/evaluation-of-antioxidant-hypolipidemic-and-antiatherogenic-property-of-lycopene-and-astaxanthin-in-atherosclerosis-induced-rats
#16
Rajesh Kumar, Kartik Janardan Salwe, Manimekalai Kumarappan
BACKGROUND: Atherosclerosis is one of the major causes of morbidity and mortality in the world. Antioxidants play a major role in prophylaxis and prevention of progression and complications of atherosclerosis. OBJECTIVE: In this study, we are evaluating the antiatherosclerotic effect of two antioxidants such as astaxanthin and lycopene. MATERIALS AND METHODS: After acclimatization, 24 male SD rats, 8-10 weeks old, 150 ± 10 g, maintained as per CPCSEA guidelines were divided into four groups of six rats each...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28538873/increased-salivary-aldehyde-dehydrogenase-1-in-non-reticular-oral-lichen-planus
#17
Arash Mansourian, Najmeh Shanbehzadeh, Seyed Javad Kia, Mahdieh-Sadat Moosavi
Background: Oral lichen planus is a potentially malignant disorder. One of the malignant transformation markers is cancer stem cells. One of the proposed marker for the detection of cancer stem cells's in head and neck cancer is aldehyde dehydrogenase. Recently it is shown that aldehyde dehydrogenase 1 expression in tissue samples is associated with oral lichen planus malignant transformation. Objective: This study evaluates salivary aldehyde dehydrogenase 1 in oral lichen planus...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28537361/payment-systems-and-oral-health-in-swedish-dental-care-observations-over-six-years
#18
C A Andås, M Hakeberg
Objective: The aim of this longitudinal study of patients in regular dental care was to compare the findings of manifest caries and fillings after a 6-year adherence to either of two optional payment models, the traditional fee-for service (FFS) model, or the new capitation model 'Dental Care for Health' (DCH). Material and methods: Data on manifest caries lesions, the number of fillings and a number of background variables were collected from both a register and a questionnaire completed by 6,299 regular dental patients who met the inclusion criteria...
December 2016: Community Dental Health
https://www.readbyqxmd.com/read/28536763/acute-visual-loss-after-botulinum-toxin-a-injection-in-the-masseter-muscle
#19
Bo Young Chun, Su Yeon Kim
PURPOSE: Acute visual loss after facial injection of cosmetic materials is rarely reported. In this study, we report one patient who developed acute visual loss after an injection of botulinum toxin A for esthetic purposes. METHODS: A 43-year-old Korean woman presented with a decrease in visual acuity to 20/800 after an injection of botulinum toxin A in the masseter muscle. The visual field testing showed an inferior altitudinal defect, and fluorescein angiography revealed a delayed arm-retinal circulation time...
May 23, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28536686/mandible-metastasis-of-small-cell-lung-cancer-mimicking-a-residual-cyst
#20
Renata Mendonça Moraes, Fabio Abreu Alves, Bruna Fernandes do Carmo Carvalho, Felipe D'Almeida Costa, Rodrigo Nascimento Lopes, Graziella Chagas Jaguar
Small cell lung carcinoma (SCLC) is an uncommon tumor characterized by an aggressive behavior with early metastasis, usually to the contralateral lung, liver, brain, and bones. There are only five cases of this particular tumor metastasizing to the oral cavity described in the English literature. We present the case of metastatic SCLC in the mandible with radiographic findings resembling a residual cyst. A 66-year-old man with previous diagnosis and treatment for a SCLC was referred to the Stomatology Department with a history of persistent pain in the mandible 1 year after the inferior right pre-molar tooth extraction...
January 2017: Autopsy & case reports
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