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https://www.readbyqxmd.com/read/29026845/osteonecrosis-of-the-jaws-in-patient-received-bisphosphonates-and-sunitinib-separately-a-case-report
#1
Farzaneh Ashrafi, Ali Derakhshandeh, Bijan Movahedian, Azadeh Moghaddas
Recently published reports have suggested that antiangiogenic drugs such as sunitinib could potentiate the osteonecrosis of the jaw (ONJ) induced by bisphosphonates (BPs) and even induce this adverse effect per se. We reported a case of ONJ with renal cell carcinoma under sunitinib medication and history of BPs therapy. A 53-year-old man was referred to the oral surgery clinic complaining of painful exposed oral lesion and bone extraction from right lower jaw in the mouth. He underwent nephrectomy followed by 5 months treatment with cycles of 50 mg sunitinib (Sutent(®)) once a day for 4 weeks followed by 2 weeks drug free before lesion exposure in October 2016...
July 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29025320/efficacy-of-itraconazole-oral-solution-using-an-alternating-week-pulse-therapy-regimen-for-treatment-of-cats-with-experimental-microsporum-canis-infection
#2
Christopher Puls, Aaron Johnson, Karrie Young, Jonathan Hare, Kelly Rosenkrans, Lisa Young, Karen Moriello
Objectives The objective of this study was to evaluate itraconazole 10 mg/ml oral solution for the treatment of Microsporum canis infection using an alternating-week pulse therapy regimen in a controlled laboratory setting. Methods Eighty cats with experimentally induced infections were randomly assigned to treatment (itraconazole vs control [sterile water]), administered 5 mg/kg orally once daily for 1 week on alternate weeks for 5 weeks, followed by a 4 week follow-up period. Topical therapeutic treatment was not administered...
October 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29024754/comparison-of-genetic-characteristics-of-canine-papillomaviruses-in-turkey
#3
Tuba Çiğdem Oğuzoğlu, Mehmet Özkan Timurkan, Bahattin Taylan Koç, Feray Alkan
Papillomavirus (PV) infections often cause benign and malignant skin neoplasia in dogs. To date, twenty types of canine papillomaviruses (CPVs) have been described worldwide. A detailed molecular characterization of CPVs in Turkey is lacking. In the present study, oral and mucosal lesions from 13 dogs with suspected CPV infection from the Mediterranean and central Anatolian regions of Turkey were analyzed. The partial gene sequences of the L1, E6, and E7 regions were compared with those of CPV types in the GenBank database...
October 9, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29023740/surveillance-and-monitoring-of-oral-health-in-elderly-people
#4
Hideo Miyazaki, Judith A Jones, Eugenio D Beltrán-Aguilar
Continued ageing of the global population is expected to pose significant challenges to maintaining optimum lifelong health in individuals and populations. Oral health is an essential element of general health and quality of life throughout an individual's life course, yet it is often neglected in integrated approaches to general health promotion. Surveillance and monitoring systems are essential for developing oral health policy and strategy at both national and community levels. As major oral diseases, dental caries and periodontal diseases are core indicators for surveillance at every stage of life...
September 2017: International Dental Journal
https://www.readbyqxmd.com/read/29023061/protective-role-of-achillea-biebersteinii-pretreatment-on-dimethoate-induced-oxidative-stress-in-guinea-pigs-liver
#5
Yahya Saleh Al-Awthan, Mohamed Ali Al-Duais, Amany Abdulfatah Hazeb, Waleed Ahmed Alril
OBJECTIVE: The present study investigated the influence of Achillea biebersteinii (Ab), a medicinal herb used widely in Yemeni's folk medicine as analgesic, antipyretic, against diarrhea and flatulence and for liver diseases, on the liver antioxidant potential of guinea pigs acutely intoxicated with dimethoate pesticide (DM). MATERIALS AND METHODS: Animals were administered with Ab aqueous extract (50 and 100 mg kg-1 b.wt., orally) or silymarin (100 mg kg-1 b.wt...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29022273/staphylococcus-lugdunensis-infections-of-the-skin-and-soft-tissue-a-case-series-and-review
#6
Lucas A Heldt Manica, Philip R Cohen
INTRODUCTION: Staphylococcus lugdunensis (S. lugdunensis) is a coagulase-negative, Gram-positive bacterium that can be isolated as a component of normal skin flora in humans. However, more recently, it has also been documented as a culprit in skin and soft tissue infections. We describe the clinical features of five individuals with S. lugdunensis-associated skin infections. We review the characteristics of other patients that were previously described with this organism as the causative agent of skin infection...
October 11, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29022086/lesions-responsible-for-delayed-oral-transit-time-in-post-stroke-dysphagia
#7
Hyun Im Moon, Seo Yeon Yoon, Tae Im Yi, Yoon Jeong Jeong, Tae Hwan Cho
INTRODUCTION: Some stroke patients show oral phase dysphagia, characterized by a markedly prolonged oral transit time that hinders oral feeding. The aim of this study was to clarify the clinical characteristics and lesions responsible for delayed swallowing. METHODS: We reviewed 90 patients with stroke. The oral processing time plus the postfaucial aggregation time required to swallow semisolid food was assessed. The patients were divided into two groups according to oral transit time, and we analyzed the differences in characteristics such as demographic factors, lesion factors, and cognitive function...
October 11, 2017: Dysphagia
https://www.readbyqxmd.com/read/29021136/distinct-angiogenic-changes-during-carcinogenesis-defined-by-novel-label-free-dark-field-imaging-in-a-hamster-cheek-pouch-model
#8
Fangyao Hu, Hannah Martin, Amy Frees Martinez, Jeffrey Everitt, Alaattin Erkanli, Walter T Lee, Mark W Dewhirst, Nirmala Ramanujam
There remain gaps in knowledge concerning how vascular morphology evolves during carcinogenesis. In this study, we imaged neovascularization by label-free dark field microscopy of a DMBA-induced hamster cheek pouch model of oral squamous cell carcinoma (SCC). Wavelength-dependent imaging revealed distinct vascular features at different imaging depths and vessel sizes. Vascular tortuosity increased significantly in high-risk lesions, while diameter decreased significantly in hyperplastic and SCC lesions. Large vessels preserved the same trends seen in the original images, whereas small vessels displayed different trends, with length and diameter increasing during carcinogenesis...
October 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/29020192/single-dose-azithromycin-for-the-treatment-of-haemophilus-ducreyi-skin-ulcers-in-papua-new-guinea
#9
Camila González-Beiras, August Kapa, Marti Vall Mayans, Raymond Paru, Sergi Gavilán, Wendy Houinei, Sibauk Bieb, Sergi Sanz, Rosario Martíns, Oriol Mitjà
Background: Haemophilus ducreyi (HD) and Treponema pallidum subsp. pertenue (TP) are major causative agents of cutaneous ulcers (CU) in the tropics. Azithromycin is recommended to treat sexually transmitted HD infections and has good in-vitro activity against HD strains from both genital and skin ulcers. We investigated the efficacy of single oral dose azithromycin on HD-CU. Methods: We conducted a community-based cohort study in Lihir Island, Papua New Guinea, from October 2014 through May 2016...
August 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29018057/pd-1-blockade-prevents-the-development-and-progression-of-carcinogen-induced-oral-premalignant-lesions
#10
Jin Wang, Tong-Xin Xie, Bingbing Wang, William N William, John Heymach, Adel K El-Naggar, Jeffrey N Myers, Carlos Caulin
Oral squamous cell carcinoma (OSCC) is preceded by progressive oral premalignant lesions (OPLs). Therefore, therapeutic strategies that prevent malignant progression of OPLs are expected to reduce the incidence of OSCC development. Immune checkpoint inhibitors that target the interaction of programmed death receptor 1 (PD-1) on T cells with the PD-1 ligand PD-L1 on cancer cells have been shown to extend the survival of patients with advanced OSCC. Here, we used the 4-Nitroquinoline-1-oxide (4-NQO) mouse model of oral carcinogenesis to test the hypothesis that PD-1 blockade may control the progression of OPLs...
October 10, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29016613/quantification-of-carious-pathogens-in-the-interdental-microbiota-of-young-caries-free-adults
#11
Denis Bourgeois, Alexandra David, Camille Inquimbert, Paul Tramini, Nicolas Molinari, Florence Carrouel
BACKGROUND: The majority of caries lesions in adults occur on the proximal tooth surfaces of the posterior teeth. A comprehensive study of the composition of the oral microbiota is fundamental for a better understanding of the etiology of interdental caries. METHODS: Twenty-five caries-free subjects (20-35 years old) were enrolled in the study. The interdental biofilm of four interdental sites were collected. The real-time polymerase chain reaction (PCR) methodology were used to quantify (i) the following bacteria: Streptococcus spp...
2017: PloS One
https://www.readbyqxmd.com/read/29016527/acute-macular-neuroretinopathy-and-peripheral-retinal-vascular-abnormalities-in-a-patient-born-hiv-seropositive
#12
Chiara Giuffrè, Alessandro Rabiolo, Eleonora Corbelli, Adriano Carnevali, Riccardo Sacconi, Lea Querques, Francesco Bandello, Giuseppe Querques
PURPOSE: To describe the case of a born HIV seropositive woman who developed outer retinal alterations secondary to vascular abnormalities in the perimacular region and in the periphery of both eyes. METHODS: Case report. RESULTS: A 21-year-old woman born HIV seropositive was referred for a routinary visit. Her best-corrected visual acuity was 20/20 in both eyes, and during the visit, only mild superotemporal metamorphopsia in the left eye was reported...
October 9, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29016342/case-report-histoplasmosis-in-himachal-pradesh-india-an-emerging-endemic-focus
#13
Vikram K Mahajan, Rashmi Kaul Raina, Suman Singh, Rattan Sagar Rashpa, Anuradha Sood, Pushpinder S Chauhan, Karaninder S Mehta, Ritu Rawat, Vikas Sharma
We describe four cases of histoplasmosis indigenous to Himachal Pradesh (India) that will be of considerable public health interest. A 48-year-old human immunodeficiency virus (HIV)-negative man with cervical and mediastinal lymphadenopathy, hepatosplenomegaly, adrenal mass, and bone marrow involvement was treated as disseminated tuberculosis without benefit. Progressive disseminated histoplasmosis was diagnosed from the fungus in smears from adrenal mass. Another 37-year-old HIV-positive man was on treatment of suspected pulmonary tuberculosis...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28991344/combined-oral-and-topical-beta-blockers-for-the-treatment-of-early-proliferative-superficial-periocular-infantile-capillary-hemangioma
#14
Hatem M Marey, Hesham F Elmazar, Sameh S Mandour, Hany A Khairy
PURPOSE: To evaluate the safety and efficacy of combined oral and topical beta blockers for the treatment of superficial periocular infantile hemangioma at the early proliferative stage. METHODS: This was a randomized, controlled comparison trial involving 25 patients. Patients were randomly enrolled into two groups: the topical and systemic treatment and systemic treatment only groups. The topical and systemic treatment group was treated with oral propranolol (1 mg/kg per day initially, increased to 2 mg/kg per day gradually in 2 weeks) and timolol maleate 0...
October 9, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28990239/tacrolimus-therapy-for-dermal-arteritis-of-the-nasal-philtrum-refractory-to-surgery-and-anti-inflammatory-therapy-doxycycline-niacinamide-and-topical-fluocinolone-in-a-dog
#15
Frane Banovic, Carmen Jerry, Elizabeth Howerth
BACKGROUND: Dermal arteritis of the nasal philtrum is a rarely reported condition commonly affecting large breed dogs. OBJECTIVE: To describe the effective treatment of nasal philtrum arteritis with topical tacrolimus in one dog. ANIMAL: A 9-year-old, intact male German shorthair pointer dog was presented with well-demarcated deep erythematous ulcers targeting exclusively the skin of the nasal philtrum, accompanied by frequent series of haemorrhage...
October 8, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28990013/primary-oral-melanoma-a-clinicopathologic-review-and-case-presentation
#16
Mayara Santos de Castro, Bruno Saulo de Assis Reis, Denismar Alves Nogueira, Marina Lara de Carli, João Adolfo Costa Hanemann, Alessandro Antônio Costa Pereira, Oslei Paes de Almeida, Felipe Fornias Sperandio
OBJECTIVE: The purpose of this manuscript is to present a clinicopathologic review of the literature concerning all the detailed cases of primary oral melanoma (OM) that were confirmed by immunohistochemistry. In addition, a pertinent case presentation is addressed. DATA SOURCES: An extensive electronic search of the literature was performed using PubMed/Medline from 1953 to 2017. Relevant articles were selected based on specific inclusion criteria. Statistical analyses were conducted by the Shapiro-Wilk, Fisher's exact, chi-square, and Z tests (α = ...
October 6, 2017: Quintessence International
https://www.readbyqxmd.com/read/28989141/melanotic-macule-in-conjunction-with-a-giant-cell-fibroma
#17
Samantha D Seitz, Thanhphuong N Dinh, Thomas Yh Yoon
INTRODUCTION: The aim of this study is to describe a case of a melanotic macule found in conjunction with a giant cell fibroma (GCF). For oral pigmented lesions without an identifiable etiologic factor, critical factors in determining the differential diagnosis are clinical history, symmetry, and uniformity of the lesions. Potential differential diagnosis includes racial pigmentation, endocrine disturbance, Peutz-Jeghers syndrome, trauma, hemochromatosis, oral malignant melanoma, or idiopathic etiology and melanotic macules...
October 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28989135/study-to-assess-activity-and-concentration-of-gammaglutamyl-transpeptidase-in-precancerous-and-cancer-patients-and-its-comparison-with-controls
#18
Anjum Aj Farooqui, Sanjay G Thete, Sayeedalaeque Bangi, Yogita J Khalekar, Neha D Nikumbh, Keeran B Jadhav, Mitesh D Kathariya
OBJECTIVE: The purpose of the study is to highlight the use of gamma-glutamyl transpeptidase (GGT) as salivary enzyme tumor marker and assess the activity and concentration of GGT in precancerous and cancer patients and compare it with the normal control. MATERIALS AND METHODS: Individuals in the age group of above 20 years were included in the study. In this study, salivary GGT was analyzed in 75 cases. The selected patients were divided into three main groups as group I (controls with normal health), group II (patients with precancerous lesions and conditions), and group III (patients with oral cancer lesions)...
October 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28988687/orantinib-versus-placebo-combined-with-transcatheter-arterial-chemoembolisation-in-patients-with-unresectable-hepatocellular-carcinoma-oriental-a-randomised-double-blind-placebo-controlled-multicentre-phase-3-study
#19
Masatoshi Kudo, Ann-Lii Cheng, Joong-Won Park, Jae Hyung Park, Po-Chin Liang, Hisashi Hidaka, Namiki Izumi, Jeong Heo, Youn Jae Lee, I-Shyan Sheen, Chang-Fang Chiu, Hitoshi Arioka, Satoshi Morita, Yasuaki Arai
BACKGROUND: Orantinib is an oral multi-kinase inhibitor. This study was done to evaluate the efficacy of orantinib combined with conventional transcatheter arterial chemoembolisation (cTACE) in patients with unresectable hepatocellular carcinoma. METHODS: This randomised, double-blind, placebo-controlled, phase 3 study was done at 75 sites in Japan, South Korea, and Taiwan. Patients with unresectable hepatocellular carcinoma, no extra-hepatic tumour spread, and Child-Pugh score of 6 or less were randomly assigned (1:1) by interactive web response system using a computer-generated sequence to receive orantinib or placebo, within 28 days of cTACE...
October 4, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28985009/odontogenic-myxoma-a-63-year-retrospective-multicenter-study-of-85-cases-in-a-brazil-population-and-a-review-of-999-cases-from-literature
#20
Ana Carolina Uchoa Vasconcelos, Felipe Martins Silveira, Ana Paula Neutzling Gomes, Sandra Beatriz Chaves Tarquinio, Ana Paula Veras Sobral, José Alcides Almeida de Arruda, Leorik Pereira da Silva, Marcia Maria Fonseca da Silveira, Larissa Ferreira Barbosa, Camila de Nazaré Alves de Oliveira Kato, Filipe Jaeger, Tarcília Aparecida da Silva, Ricardo Alves Mesquita
BACKGROUND: Odontogenic myxoma (OM) is an uncommon neoplasm of the jaws. Considering the importance of defining the relative incidence and demographic profile of these lesions in South America, the aim of this study was to analyze the clinical and imagiological features of OM from three South American oral pathology services and to discuss these findings in light of the literature. METHODS: Data regarding age, gender, anatomic site and imagiological features from 85 cases of OM were collected...
October 6, 2017: Journal of Oral Pathology & Medicine
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