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https://www.readbyqxmd.com/read/29677542/innovative-perception-on-using-tiron-to-modulate-the-hepatotoxicity-induced-by-titanium-dioxide-nanoparticles-in-male-rats
#1
Ashraf Morgan, Marwa A Ibrahim, Mona K Galal, Hanan A Ogaly, Reham M Abd-Elsalam
The extensive application of titanium dioxide nanoparticles (TiO2 NPs) in the food industry arouses a debate regarding the probable risk associated with their use. Several recent studies reported that most nanoparticles (NPs) have adverse actions on the liver. The objective of this study is to examine whether Tiron plays a modulatory role against apoptotic damage induced by TiO2 NPs in rat livers. Forty rats were randomly divided into 4 groups; a control group received phosphate-buffered saline, an intoxicated group received 100 mg/kg/day of TiO2 NPs for 60 days, a treated group received 470 mg/kg/day of Tiron for the last 14 days after TiO2 NPs administration, and a Tiron group received Tiron only as previously mentioned...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29676975/eighteen-month-clinical-study-of-universal-adhesives-in-noncarious-cervical-lesions
#2
V C Ruschel, S Shibata, S C Stolf, Y Chung, L N Baratieri, H O Heymann, R Walter
OBJECTIVE: To evaluate the clinical performance of Scotchbond Universal (3M Oral Care) and Prime & Bond Elect (Dentsply Sirona) in the restoration of noncarious cervical lesions (NCCLs). METHODS AND MATERIALS: This was a randomized controlled clinical trial involving 63 subjects. Two hundred and three NCCLs were restored using Scotchbond Universal and Prime & Bond Elect using both an etch-and-rinse and a self-etch technique. Lesions were notch-shaped NCCLs, and the restorations were placed without any mechanical retention...
May 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29675626/imaging-of-the-sublingual-and-submandibular-spaces
#3
REVIEW
Swapnil Patel, Alok A Bhatt
Divided by the mylohyoid muscle, the sublingual and submandibular spaces represent a relatively small part of the oral cavity, but account for a disproportionate amount of pathological processes. These entities are traditionally separated into congenital, infectious/inflammatory, vascular and neoplastic aetiologies. This article reviews the relevant anatomy, clinical highlights and distinguishing imaging features necessary for accurate characterisation. TEACHING POINTS: • The mylohyoid sling is a key anatomical landmark useful in surgical planning...
April 19, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29675295/combination-of-structural-and-vascular-optical-coherence-tomography-for-differentiating-oral-lesions-of-mice-in-different-carcinogenesis-stages
#4
Ping-Hisen Chen, Chien-Hsien Wu, Yi-Fen Chen, Yi-Chen Yeh, Bo-Han Lin, Kuo-Wei Chang, Pei-Yu Lai, Ming-Chih Hou, Ching-Liang Lu, Wen-Chuan Kuo
Differentiating between early malignancy and benign lesions in oral cavities is difficult using current optical tools. As has been shown in previous studies, microvascular changes in squamous epithelium can be regarded as a key marker for diagnosis. We propose the combination of structural and vascular optical coherence tomography (OCT) imaging for the investigation of disease related changes. Progressive thickness changes of epithelium and the destruction of underlying lamina propria was observed during cancer development in a 4- nitroquinoline-1-oxide (4NQO) mouse model...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29674818/efficacy-of-denoising-and-enhancement-filters-for-detection-of-approximal-and-occlusal-caries-on-digital-intraoral-radiographs
#5
Abbas Shokri, Shahin Kasraei, Sima Lari, Majid Mahmoodzadeh, Amin Khaleghi, Saeid Musavi, Vahid Akheshteh
Background and Objectives: Image processing and enhancement filters can significantly improve the diagnostic value of digital radiographs. Evidence shows that increasing the contrast and filtering improve the diagnostic accuracy for caries detection. This study sought to assess the diagnostic accuracy of original and enhanced digital radiographs for the detection of approximal and occlusal caries. Subjects and Methods: In this experimental study, incipient carious lesions were artificially created on 120 proximal and occlusal surfaces of human extracted permanent molar and premolar teeth...
March 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29674247/apple-peel-polyphenols-reduce-mitochondrial-dysfunction-in-mice-with-dss-induced-ulcerative-colitis
#6
Pantea Rahmani Yeganeh, Jade Leahy, Schohraya Spahis, Natalie Patey, Yves Desjardins, Denis Roy, Edgard Delvin, Carole Garofalo, Jean-Philippe Leduc-Gaudet, David St-Pierre, Jean-François Beaulieu, André Marette, Gilles Gouspillou, Emile Levy
Inflammatory bowel diseases (IBDs) are multifaceted and relapsing immune disorders, which necessitate long-term dependence on powerful drugs. As the use of natural product-based therapies has emerged as a promising intervention, the present study aimed to further characterize dried apple peel powder (DAPP) mechanisms of action and evaluate the preventive and curative effects of DAPP on mitochondrial functions in a murine model. Induction of intestinal inflammation in mice is performed by oral administration of the dextran sodium sulfate (DSS) at 2...
March 21, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29673799/clinical-features-and-presentation-of-oral-potentially-malignant-disorders
#7
REVIEW
Saman Warnakulasuriya
Oral potentially malignant disorders (OPMDs) are conditions that precede the onset of invasive cancers of the oral cavity. The term embraces precancerous lesions and conditions referred to in earlier World Health Organization (WHO) definitions. Leukoplakia is the most common OPMD; erythroplakia, although rare, is more serious. Several variants of leukoplakia are recognized, and clinical subtyping may help determine the prognosis to a limited extent. Biopsy is essential to confirm the provisional clinical diagnosis, and timely referral to a specialist is indicated...
April 4, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29673751/-primary-cutaneous-cd30-t-cell-lymphoproliferation-during-treatment-with-fingolimod-case-report-and-literature-review
#8
E Cesbron, J-B Monfort, C Giannesini, P Duriez, P Moguelet, P Senet, C Francès, A Barbaud, F Chasset
BACKGROUND: Fingolimod is an oral immunomodulator approved for relapsing-remitting multiple sclerosis. We report a case of a primary cutaneous CD30+ T-cell lymphoproliferation occurring 6 months after initiation of fingolimod. Based on a systematic literature review, the characteristics of these fingolimod-induced lymphoproliferative disorders are described. PATIENTS AND METHODS: A 56-year-old woman developed cutaneous indurated and ulcerated nodular lesions 6 months after starting fingolimod for active relapsing-remitting multiple sclerosis...
April 16, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29672672/mri-and-neuropsychological-correlates-in-african-americans-with-hypertension-and-left-ventricular-hypertrophy
#9
B Waldron-Perrine, J E Kisser, A Brody, E M Haacke, R Dawood, S Millis, P Levy
Background: African Americans (AA) are at high risk for hypertension (HTN) and poor blood pressure (BP) control. Persistently elevated BP contributes to cardiovascular morbidity. White matter hyperintensities (WMH) are a definable magnetic resonance imaging (MRI) marker of cerebrovascular injury linked to impairments in higher level thinking (i.e., executive functions), memory formation and speed of perceptual-motor processing. Methods: This sub-investigation evaluated neuropsychological functioning in association with WMH on brain MRIs in 23 otherwise healthy hypertensive AAs participating in an NIH-funded study of the effects of Vitamin D on BP and cardiac remodeling in AA patients 30-74 years of age with HTN and left ventricular hypertrophy...
April 17, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29672635/differential-transmission-of-the-molecular-signature-of-rbsp3-limd1-and-cdc25a-in-basal-parabasal-versus-spinous-of-normal-epithelium-during-head-and-neck-tumorigenesis-a-mechanistic-study
#10
Shreya Sarkar, Neyaz Alam, Syam Sundar Mandal, Kabita Chatterjee, Supratim Ghosh, Susanta Roychoudhury, Chinmay Kumar Panda
Head and neck squamous cell carcinoma (HNSCC) is a global disease and mortality burden, necessitating the elucidation of its molecular progression for effective disease management. The study aims to understand the molecular profile of three candidate cell cycle regulatory genes, RBSP3, LIMD1 and CDC25A in the basal/ parabasal versus spinous layer of normal oral epithelium and during head and neck tumorigenesis. Immunohistochemical expression and promoter methylation was used to determine the molecular signature in normal oral epithelium...
2018: PloS One
https://www.readbyqxmd.com/read/29670741/coexisting-sublingual-dermoid-cyst-and-heterotopic-gastrointestinal-cyst-case-report
#11
Göksel Şimşek-Kaya, İrem-Hicran Özbudak, Dinçer Kader
A heterotopic oral gastrointestinal cyst coexisting with a lingual dermoid cyst is a rare condition, with only 3 reported cases in the English-language literature. Clinically, both gastrointestinal and dermoid cysts tend to manifest as an asymptomatic swelling. Cysts above the mylohyoid often present with sublingual swelling, whereas those below the mylohyoid present with submental swelling. Increased salivation, altered speech, dyspnea and difficulties in eating, swallowing and respiration may be present, depending on the size of the cyst...
February 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29670740/gingival-varices-treated-with-monoethanolamine-oleate-a-rare-case-report
#12
Sarah Campos-de Sales, Camila-Nazaré-Alves-de Oliveira Kato, Mariana-Saturnino de Noronha, Wagner-Henriques Castro, Ricardo-Alves Mesquita
Varices are benign blood vessel lesions that are common in the head and neck regions. The aim of this case report is to highlight an uncommon case of gingival varices and its diagnosis and management. This is the second time that a case of varices has been reported at this site. Monoethanolamine oleate (MO) at a 2.5% concentration was used as the treatment. A 66-year-old woman presented spontaneous gingival bleeding in the region of the mandibular first and second left molars. A macula and gingival enlargement on the interproximal papillae were observed...
February 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29670737/oral-foreign-body-granuloma-to-soft-tissue-fillers-report-of-two-cases-and-review-of-the-literature
#13
Paris Tamiolakis, Evangelia Piperi, Panagiotis Christopoulos, Alexandra Sklavounou-Andrikopoulou
The increasing demand for cosmetic procedures in the orofacial area nowadays, results in a growing number of complications attributable to soft tissue fillers, including the development of foreign body granuloma. The purpose of this study is to present two additional cases of oral foreign body granulomas caused by liquid silicone and hyaluronic acid respectively and review the pertinent literature regarding the demographics, the clinical appearance, the histopathology and the treatment of these lesions. Key words: Oral foreign body granuloma, hyaluronic acid, silicone, soft tissue filler...
February 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29669018/evaluation-of-autofluorescent-eimeria-maxima-oocysts-as-a-potential-indicator-of-non-viability-when-enumerating-oocysts
#14
L C Beer, L R Bielke, J R Barta, O B Faulkner, J D Latorre, W N Briggs, K M Wilson, M F A Baxter, G Tellez, B M Hargis
Aging, poor oxygenation, or improper storage temperature can lead to variable Eimeria oocyst viability, which is not readily assessed microscopically. Under fluorescent microscopy, some aged Eimeria maxima (EM) oocysts were strongly autofluorescent (AF) within the oocystoplasm and sporocysts, whereas others were distinctly non-fluorescent, leading to the hypothesis that non-viable oocysts may be detectible using this simple approach. Using accelerated aging conditions at 45°C, two experiments were conducted to evaluate variable percentages of autofluorescent EM oocysts on body weight gain (BWG), lesion scores (LS), and total oocyst shedding (OS) per bird...
April 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29668637/successful-mesenchymal-stem-cell-treatment-of-leg-ulcers-complicated-by-behcet-disease-a-case-report-and-literature-review
#15
Yanhong Li, Zhongming Wang, Yi Zhao, Yubin Luo, Wangdong Xu, Tony N Marion, Yi Liu
RATIONALE: Behçet disease (BD) is a recurrent vasculitis characterized by oral and genital mucous membrane ulcers, uveitis, and skin lesions but only rarely leg ulcers. To our knowledge, no efficacious therapy has been described for BD patients with complicating, destructive leg ulcers. PATIENT CONCERNS: Here, We report the case of a 55-year-old woman with generalized erythema nodosum-like, papulopustular lesions, recurrent oral and genital ulcers accompanied with recurrent leg ulcers and trouble walking...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668581/clearance-of-human-papillomavirus-related-anal-condylomas-after-oral-and-endorectal-multistrain-probiotic-supplementation-in-an-hiv-positive-male-a-case-report
#16
Giancarlo Ceccarelli, Eugenio Nelson Cavallari, Stefano Savinelli, Luigi Bianchi, Alessandra Pierangeli, Francesco Vullo, Antonio Ciardi, Gabriella D'ettorre
INTRODUCTION: Here we present the case of a 56-year-old human immunodeficiency virus (HIV)-infected man with multiple anal condylomas and positivity for human papilloma virus (HPV) 18 on anal brushing. Biopsies of the anal mucosa led to the diagnosis of Bowen's disease and a subsequent pelvic magnetic resonance imaging (MRI) scan evidenced multiple reactive lymphoadenopathies and large intra-anal condylomas. The patient was treated with a complete excision of Bowen's lesion and with a 4 months course of supplementation with a high concentration multistrain probiotic formulation administered orally and by rectal instillation with the purpose to reduce local inflammation and to enhance local mucosal immunity...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29667077/a-case-of-beh%C3%A3-et-s-disease-with-various-gastrointestinal-findings
#17
Kentaro Tominaga, Kenya Kamimura, Kazuya Takahashi, Junji Yokoyama, Shuji Terai
Behçet's disease (BD) is a systemic inflammatory disorder involving the oral and genital mucosa, skin, eyes, gastrointestinal tract, joints, vasculature, and nervous. The gastrointestinal lesions accompanying with BD can extend along the full length of the tract, from the mouth to the anus, and show various clinical characteristics which is difficult to be differentiate from the other inflammatory bowel diseases including ulcerative colitis and Crohn's disease. Hence, the differential diagnosis is difficult and can affect treatment outcomes...
April 17, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29666713/comprehensive-treatment-of-severe-periodontal-and-periimplant-bone-destruction-caused-by-iatrogenic-factors
#18
Gregor-Georg Zafiropoulos, Andreas Parashis, Taha Abdullah, Evangelos Sotiropoulos, Gordon John
Dental implant success requires placement after periodontal therapy, with adequate bone volume, plaque control, primary stability, control of risk factors, and use of well-designed prostheses. This report describes the surgical and prosthetic management of a patient with severe iatrogenic periodontal/periimplant bone destruction. Methods. A 55-year-old female smoker with fixed partial dentures (FPDs) supported on teeth and implants presented with oral pain, swelling, bleeding, and a 10-year history of multiple implant placements and implants/prosthesis failures/replacements...
2018: Case Reports in Dentistry
https://www.readbyqxmd.com/read/29666079/oral-superficial-haemosiderotic-lymphovascular-malformation-a-rare-presentation
#19
Manar Alhassani, Vijay Santhanam, Shadi Basyuni
We present an extremely rare case of a 53-year-old woman with an intraoral superficial haemosiderotic lymphovascular malformation (SHLM), also known as hobnail haemangioma. SHLM is a rare, benign, vascular tumour first described as targetoid haemosiderotic haemangioma, with only a handful of cases reported to present in the oral cavity. The diagnosis was established following complete surgical excision of the lesion, and after 14 months, there are still no signs of recurrence. Although SHLM is an uncommon condition, accurate and timely diagnosis is valuable in distinguishing these lesions from their more serious competing differential diagnoses...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29666025/-ingestion-of-caustic-substances-an-analysis-of-the-safety-and-benefit-of-a-less-aggressive-protocol
#20
Noelia Ripoll Trujillo, Lidia Martínez Sánchez, Anna Habimana Jordana, Victoria Trenchs Sainz de La Maza, Víctor Vila Miravet, Carles Luaces Cubells
INTRODUCTION: The ingestion of a caustic agent is the most common cause of admission after being in contact with a domestic product. A group of patients could be considered low risk and not require aggressive procedures such a corticosteroid administration and endoscopy, especially in the paediatric population. OBJECTIVE: To evaluate the safety and benefit of a less aggressive protocol for patients defined as low risk. MATERIAL AND METHODS: An analytical-observational study conducted on patients who consulted for caustic ingestion between January 2011 and December 2015...
April 14, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
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