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https://www.readbyqxmd.com/read/28648585/the-synthesis-and-antitumor-activity-of-lithocholic-acid-and-its-derivatives
#1
Xiao-Long He, Yajing Xing, Xiang-Zhong Gu, Jie-Xin Xiao, Ying-Ying Wang, Zhengfang Yi, Wen-Wei Qiu
In this paper, a new and concise synthetic route of lithocholic acid (LCA) using commercially available steroid source deoxycholic acid is reported. A series of amide derivatives of LCA were also synthesized and investigated for their activity against the growth of MCF-7 and MCF-7/ADR cells using the sulforhodamine B assay. For MCF-7, the most potent compound 20 showed a 20-fold higher antitumor activity than LCA. For MCF-7/ADR, the most potent compound 24 showed a 22-fold higher antitumor activity than LCA...
June 22, 2017: Steroids
https://www.readbyqxmd.com/read/28643311/-long-term-outcomes-of-laparoscopic-low-anterior-resection-of-rectal-carcinoma-with-preservation-of-the-left-colic-artery
#2
Jian Shen, Minzhe Li, Yanfu Du, Dehong Xie, Hao Qu, Yudong Zhang
OBJECTIVE: To investigate the long-term outcomes of laparoscopic low anterior resection of rectal carcinoma with preservation of the left colic artery(LCA). METHODS: Clinicopathological and follow-up data of 322 cases with rectal carcinoma undergoing laparoscopic low anterior resection in Department of General Surgery, Beijing Chaoyang Hospital Affiliated to Capital Medical University from January 2007 to December 2011 were retrospectively analyzed. According to the different surgical methods of inferior mesenteric artery (IMA), cases were divided into the trial group (LCA preservation plus lymph nodes around IMA root dissection, 168 cases) and the control group(origin of IMA ligation, 154 cases)...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28632025/use-of-latent-class-analysis-to-define-groups-based-on-validity-cognition-and-emotional-functioning
#3
Ruth T Morin, Bradley N Axelrod
OBJECTIVE: Latent Class Analysis (LCA) was used to classify a heterogeneous sample of neuropsychology data. In particular, we used measures of performance validity, symptom validity, cognition, and emotional functioning to assess and describe latent groups of functioning in these areas. METHOD: A data-set of 680 neuropsychological evaluation protocols was analyzed using a LCA. Data were collected from evaluations performed for clinical purposes at an urban medical center...
June 15, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28630602/comparing-the-performance-of-improved-classify-analyze-approaches-for-distal-outcomes-in-latent-profile-analysis
#4
John J Dziak, Bethany C Bray, Jieting Zhang, Minqiang Zhang, Stephanie T Lanza
Several approaches are available for estimating the relationship of latent class membership to distal outcomes in latent profile analysis (LPA). A three-step approach is commonly used, but has problems with estimation bias and confidence interval coverage. Proposed improvements include the correction method of Bolck, Croon, and Hagenaars (BCH; 2004), Vermunt's (2010) maximum likelihood (ML) approach, and the inclusive three-step approach of Bray, Lanza, & Tan (2015). These methods have been studied in the related case of latent class analysis (LCA) with categorical indicators, but not as well studied for LPA with continuous indicators...
October 2016: Methodology: European Journal of Research Methods for the Behavioral & Social Sciences
https://www.readbyqxmd.com/read/28628153/-13-cases-of-littoral-cell-angioma-in-spleens
#5
(no author information available yet)
OBJECTIVE: To investigate the clinicopathological features, morphological characteristics, immunophenotypes of littoral cell angioma (LCA) in spleen, and to provide new evidence for making diagnosis and avoiding misdiagnosis. METHODS: Clinicopathological data, histological characteristics of 13 cases of LCA were retrospectively studied and immunohistochemical staining was imposed on the paraffi-nembedded specimens, and 5 cases of cavernous hemangioma, 4 cases of normal littoral cells of spleens were used as control groups, simultaneously...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28627880/site-specific-fucosylation-analysis-identifies-glycoproteins-associated-with-aggressive-prostate-cancer-cell-lines-using-tandem-affinity-enrichments-of-intact-glycopeptides-followed-by-mass-spectrometry
#6
Jianliang Zhou, Weiming Yang, Yingwei Hu, Naseruddin Hoti, Yang Liu, Punit Shah, Shisheng Sun, David J Clark, Stefani N Thomas, Hui Zhang
Fucosylation (Fuc) of glycoproteins plays an important role in regulating protein function and has been associated with the development of several cancer types including prostate cancer (Pca). Therefore, the research of Fuc glycoproteins has attracted increasing attention recently in analytical field. Herein, a strategy based on lectin affinity enrichments of intact glycopeptides followed by mass spectrometry has been established to evaluate the specificities of various Fuc-binding lectins for glycosite-specific Fuc analysis of non-aggressive (NAG) and aggressive (AG) Pca cell lines...
June 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28623835/life-cycle-assessment-of-treatment-and-handling-options-for-a-highly-saline-brine-extracted-from-a-potential-co2-storage-site
#7
Hafiz H Salih, Jiaxing Li, Ruth Kaplan, Seyed A Dastgheib
Carbon dioxide (CO2) injection in deep saline aquifers is a promising option for CO2 geological sequestration. However, brine extraction may be necessary to control the anticipated increase in reservoir pressure resulting from CO2 injection. The extracted brines usually have elevated concentrations of total dissolved solids (TDS) and other contaminants and require proper handling or treatment. Different options for the handling or treatment of a high-TDS brine extracted from a potential CO2 sequestration site (Mt...
June 12, 2017: Water Research
https://www.readbyqxmd.com/read/28618056/improving-substance-information-in-usetox%C3%A2-part-1-discussion-on-data-and-approaches-for-estimating-freshwater-ecotoxicity-effect-factors
#8
Erwan Saouter, Karin Aschberger, Peter Fantke, Michael Z Hauschild, Stephanie K Bopp, Aude Kienzler, Alicia Paini, Rana Pant, Michela Secchi, Serenella Sala
The scientific consensus model USEtox® is recommended by the European Commission as the reference model to characterize life cycle chemical emissions in terms of their potential human toxicity and freshwater aquatic ecotoxicity impacts in the context of the International Reference Life Cycle Data System (ILCD) Handbook and the Environmental Footprint pilot phase looking at products (PEF) and organisations (OEF). Consequently, this model has been systematically used within the PEF/OEF pilot phase by 25 EU industry sectors, which manufacture a wide variety of consumer products...
June 15, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28612566/-latent-class-analysis-of-health-seeking-behaviors-for-children-in-floating-populations-in-sichuan
#9
Cheng-Han Xiao, Yang Yang, Xiao Ma
OBJECTIVES: To understand the characteristics associated with health care seeking behaviors for children in floating populations. METHODS: A stratified multi-stage sampling strategy with PPS method was employed to select 1 943 children aging 0-7 yr. in the floating populations in Sichuan province, which included 605 flowing out, 468 left-at-home, 822 migrated inhabitants, and 48 returned. Latent class analysis (LCA) was performed to establish potential feature classifications for their use of child health care service (physical examination card, free medical examination, vaccination certificate and immunization) ...
January 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28612353/lca-case-study-tertiary-treatment-process-options-for-wastewater-reuse
#10
Erwan Carré, Joana Beigbeder, Vincent Jauzein, Guillaume Junqua, Miguel Lopez-Ferber
Tertiary treatment process (including filtration and/or disinfection) is necessary to obtain a water quality suited for high-quality reuse from wastewater treatment. Industrial pilots representing small real size treatment units were set up downstream of a conventional secondary treatment of a wastewater treatment plant in the South of France and their performance followed for two years. Life-cycle assessment (LCA) methodology is used to compare the environmental impacts of different treatment processes. Five tertiary treatment trains were studied: 1) sand filtration + storage followed by ultraviolet (UV) dynamic reactor disinfection (SF-UVD), 2) sand filtration (SF) + UV batch reactor disinfection (SF-UVB), 3) ultrafiltration (UF), 4) ultrafiltration and UV batch reactor disinfection (UF-UVB), 5) microfiltration (MF) and storage followed by dynamic UV disinfection (MF-UVD)...
June 13, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28609690/what-do-we-know-about-child-abuse-and-neglect-patterns-of-co-occurrence-a-systematic-review-of-profiling-studies-and-recommendations-for-future-research
#11
REVIEW
Agata Debowska, Dominic Willmott, Daniel Boduszek, Adele D Jones
Latent class (LCA) and latent profile (LPA) analysis represent methodological approaches to identify subgroups of maltreated individuals. Although research examining child abuse and neglect (CAN) profiles is still rare, the application of person-centered techniques to clarify CAN types co-occurrence has substantially increased in recent years. Therefore, the aim of the present study was to provide a summary and critical evaluation of the findings of LCA/LPA child maltreatment research to: (a) systemize the current understanding of patterns of maltreatment across populations and (b) elucidate interactive effects of CAN types on psychosocial functioning...
June 10, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28609673/risk-taking-behaviors-and-subgrouping-of-suicide-in-iran-a-latent-class-analysis-of-national-registries-data
#12
Ahmad Hajebi, Abbas Abbasi-Ghahramanloo, Seyed Sepehr Hashemian, Seyed Reza Khatibi, Masomeh Ghasemzade, Mahmoud Khodadost
Suicide is one the most important public health problem which is rapidly growing concerns. The aim of this study was to subgroup suicide using LCA method. This cross-sectional study was conducted in Iran based on 66990 records registered in Ministry of Health in 2014. A case report questionnaire in the form of software was used for case registries. Latent class analysis was used to achieve the research objectives. Four latent classes were identified; (a) Non-lethal attempters without a history of psychiatric disorders, (b) Non-lethal attempters with a history of psychiatric disorders, (c) Lethal attempters without a history of psychiatric disorders, (d) Lethal attempters with a history of psychiatric disorders...
June 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28607812/littoral-cell-angioma-of-the-spleen-a-case-report
#13
Dongming Liu, Zhaohui Chen, Tongtong Wang, Baichang Zhang, Hongyuan Zhou, Qiang Li
Littoral-cell angioma (LCA), a primary angioma which clinically belongs to splenic hemangioma, can be mostly found in normal spleen red sinus shore cells of reticuloendothelial cell system. The cells of LCA strongly express endothelial and tissue cell associated antigens that indicate a dual differentiation characteristic; whereas only endothelial cell markers are positive in normal spleen red sinus shore cells. Diagnosis of LCA relies on histopathology. Regular follow-up is needed to monitor recurrence and metastasis...
May 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28602425/comparative-life-cycle-assessment-of-mswi-fly-ash-treatment-and-disposal
#14
Florian Huber, David Laner, Johann Fellner
Municipal solid waste incineration (MSWI) fly ash constitutes a hazardous waste. The possibilities for managing this waste comprise disposal at underground deposits or at above-ground landfills after cement stabilisation, application of the FLUREC process, thermal treatment in a dedicated furnace or thermal co-treatment together with combustible hazardous waste. A comparative life cycle assessment (LCA) study was conducted in order to assess the environmental impact of these five MSWI fly ash disposal options with regard to two different time horizons (100years, indefinite)...
June 8, 2017: Waste Management
https://www.readbyqxmd.com/read/28601356/school-readiness-of-maltreated-preschoolers-and-later-school-achievement-the-role-of-emotion-regulation-language-and-context
#15
Carlomagno C Panlilio, Brenda Jones Harden, Jeffrey Harring
Guided by bio-ecological theory, this study aimed to: (1) identify heterogeneity in the developmental patterns of emotion regulation for maltreated preschool-aged children; (2) examine the role of gender, language, placement instability, cognitive stimulation, and emotional support on patterns of stability and change of emotion regulation over time; and (3) elucidate the role of emotion regulation/dysregulation patterns on later academic achievement. This study utilized data from the first cohort of the National Survey of Child and Adolescent Well-Being...
June 7, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28598846/neuropsychiatric-symptoms-and-cognitive-impairment-understanding-the-importance-of-co-morbid-symptoms
#16
Moyra E Mortby, Richard Burns, Ranmalee Eramudugolla, Zahinoor Ismail, Kaarin J Anstey
BACKGROUND: Neuropsychiatric symptoms (NPS) are common in older adults with cognitive impairment, yet little is known about population-based prevalence and clinical implications of co-morbid symptom presentation across the spectrum from normal cognition to dementia. OBJECTIVE: To characterize the prevalence of NPS and explore the clinical implications of co-morbid symptom presentation. METHODS: Cross-sectional study of 1,417 older adults (aged 73-79) with dementia (n = 40); with mild cognitive impairment (MCI; n = 133); who are 'cognitively normal, but-at-risk' (CN-AR; n = 397); and who are cognitively normal (n = 847)...
June 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28594892/a-behavioral-typology-of-opioid-overdose-risk-behaviors-among-recent-veterans-in-new-york-city
#17
Alex S Bennett, Andrew Golub, Luther Elliott
OBJECTIVE: To identify meaningful classes of opioid-using military veterans in terms of self-reported opioid overdose risk behaviors. METHOD: The study recruited a sample of 218 military veterans in the NYC area who were discharged from active duty service after September 11, 2001 and reported past-month opioid use. Survey data including measures of mental health, social stressors, substance use, and opioid-related overdose risk behaviors were analyzed using Latent Class Analysis (LCA)...
2017: PloS One
https://www.readbyqxmd.com/read/28586317/right-lateral-versus-left-lateral-view-for-forearm-coronary-angiography-an-operator-radiation-exposure-and-image-quality-study
#18
Elena Rodríguez-González, Miguel Castanedo-Álvarez, Ebrey León-Aliz, Jaime Benitez-Peyrat, Juan Francisco Oteo, Mónica Hernández-Hernández, Alfredo Montes-Uruén, Josebe Gorigolzarri-Artaza, María Alejandra Restrepo-Córdoba, Xavier Pifarré-Martínez, Javier Goicolea, Arturo García-Touchard
OBJECTIVES: The aim of this study was to analyze the operator radiation exposure (ORE) and the image quality in a coronary angiography (CA) of the standard left lateral view (LLV) and compare it with an alternative right lateral view (RLV). BACKGROUND: Interventional cardiologists are exposed to high doses of scatter radiation, especially in angulated projections. METHODS: We prospectively included consecutive patients who underwent diagnostic CA...
June 6, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28585279/serum-bile-acid-level-and-fatty-acid-composition-in-chinese-children-with-non-alcoholic-fatty-liver-disease
#19
Li Ping Lu, Yan Ping Wan, Peng Cheng Xun, Ke Jun Zhou, Cheng Chen, Si Yang Cheng, Min Zhong Zhang, Chun Hua Wu, Wei Wei Lin, Ying Jiang, Hai Xia Feng, Jia Lu Wang, Ka He, Wei Cai
OBJECTIVE: To determine serum bile acid (BA) and fatty acid (FA) profiles in Chinese children with non-alcoholic fatty liver disease (NAFLD) METHODS: Seventy-six children aged 4-17 years were categorized into three groups: none NAFLD (control), mild, and moderate/severe NAFLD groups respectively based on liver ultrasonography. Serum BAs and FAs were quantified by mass spectrometry and gas chromatography separately. General linear models were performed to assess the differences across groups...
June 6, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28583875/quantitative-profiling-of-19-bile-acids-in-rat-plasma-liver-bile-and-different-intestinal-section-contents-to-investigate-bile-acid-homeostasis-and-the-application-of-temporal-variation-of-endogenous-bile-acids
#20
Tingting Yang, Ting Shu, Guanlan Liu, Huifang Mei, Xiaoyu Zhu, Xin Huang, Luyong Zhang, Zhenzhou Jiang
Bile acid homeostasis is maintained by liver synthesis, bile duct secretion, microbial metabolism and intestinal reabsorption into the blood. When drug insults result in liver damage, the variances of bile acids (BAs) are related to the physiological status of the liver. Here, we established a method to simultaneously quantify 19 BAs in rat plasma, liver, bile and different intestinal section contents (duodenum, jejunum, ileum, cecum and colon) using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) to reveal the pattern of bile acid homeostasis in the enterohepatic circulation of bile acids in physiological situations...
June 2, 2017: Journal of Steroid Biochemistry and Molecular Biology
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