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Jingyan Yang, Virginie Lafage, Renaud Lafage, Justin Smith, Eric O Klineberg, Christopher I Shaffrey, Gregory Mundis, Richard Hostin, Douglas Burton, Christopher P Ames, Shay Bess, Han Jo Kim, Frank Schwab
STUDY DESIGN: Retrospective review of prospective multicenter database. OBJECTIVE: To investigate the determinants of patient satisfaction with respect to changes in functional limitations two-year after spinal deformity surgery. SUMMARY OF BACKGROUND DATA: For operatively treated adult spine deformity (ASD), patient satisfaction has become an important component of evaluating quality of care. METHODS: 430 operative ASD patients with two-year follow-up were analyzed...
June 21, 2018: Spine
Bengt Gårdlund, Natalia O Dmitrieva, Carl F Pieper, Simon Finfer, John C Marshall, B Taylor Thompson
PURPOSE: Septic shock is a highly heterogeneous condition which is part of the challenge in its diagnosis and treatment. In this study we aim to identify clinically relevant subphenotypes of septic shock using a novel statistic al approach. METHODS: Baseline patient data from a large global clinical trial of septic shock (n = 1696) was analysed using latent class analysis (LCA). This approach allowed investigators to identify subgroups in a heterogeneous population by estimating a categorical latent variable that detects relatively homogeneous subgroups within a complex phenomenon...
June 8, 2018: Journal of Critical Care
Maria I Patrício, Alun R Barnard, Kanmin Xue, Robert E MacLaren
INTRODUCTION: Choroideremia is an X-linked inherited retinal degeneration that causes blindness in afflicted males by middle age. The causative gene, CHM, plays a key role in intracellular trafficking pathways, and its disruption impairs cell homeostasis. Areas covered: The mechanism by which mutations in CHM cause choroideremia is still under debate. Here we describe the molecular defects in choroideremia cells regarding both the deficiency of prenylation and the involvement of Rab GTPases...
June 22, 2018: Expert Opinion on Biological Therapy
Allan Hayato Shimako, Ligia Tiruta-Barna, Ana Barbara Bisinella de Faria, Aras Ahmadi, Mathieu Spérandio
Including the temporal dimension in the Life Cycle Assessment (LCA) method is a very recent research subject. A complete framework including dynamic Life Cycle Inventory (LCI) and dynamic Life Cycle Impact Assessment (LCIA) was proposed with the possibility to calculate temporal deployment of climate change and ecotoxicity/toxicity indicators. However, the influence of different temporal parameters involved in the new dynamic method was not still evaluated. In the new framework, LCI and LCIA results are obtained as discrete values in function of time (vectors and matrices)...
May 15, 2018: Science of the Total Environment
Shunwen Bai, Xinyue Zhao, Dawei Wang, Xuedong Zhang, Nanqi Ren
Environmental impacts of biological wastewater treatment technologies (BWTTs) can be evaluated by life cycle assessment (LCA). However, very few efforts have been made to expand the ranges of results acceptance and promote stakeholders to participate in the results analysis. To facilitate the evaluation reaching more wide and deep understanding, this study proposed to employ multiple weighting methods and the Conjoint Analysis. To investigate the feasibility, an illustrative case of a bioaugmented constructed wetland was carried out...
June 14, 2018: Bioresource Technology
Thomas Hennequin, Hjalte Jomo Danielsen Sørup, Yan Dong, Karsten Arnbjerg-Nielsen
Sustainable flood management is a basic societal need. In this article, life cycle assessment is used to compare two ways to maintain the state of a coastal urban area in a changing climate with increasing flood risk. On one side, the construction of a dike, a hard and proactive scenario, is modelled using a bottom up approach. On the other, the systematic repair of houses flooded by sea surges, a post-disaster measure, is assessed using a Monte Carlo simulation allowing for aleatory uncertainties in predicting future sea level rise and occurrences of extreme events...
June 13, 2018: Science of the Total Environment
Rosa M Crum, Kerry M Green, Elizabeth A Stuart, Lareina N La Flair, Marc Kealhofer, Andrea S Young, Noa Krawczyk, Kayla N Tormohlen, Carla L Storr, Anika A H Alvanzo, Ramin Mojtabai, Lauren R Pacek, Bernadette A Cullen, Beth A Reboussin
INTRODUCTION: Although prior clinical and population-based studies have demonstrated comorbidity between mood and alcohol use disorders (AUD), there is a paucity of research assessing whether mood disorders predict transition across stages of alcohol involvement. METHOD: Hypothesizing that mood disorders predict transition across sex-specific alcohol involvement stages, we used prospective data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a nationally representative survey of US adults, which included male (n = 14,564) and female (n = 20,089) participants surveyed in 2001-2 and re-interviewed in 2004-5...
April 10, 2018: Drug and Alcohol Dependence
Didem Civancik-Uslu, Laura Ferrer, Rita Puig, Pere Fullana-I-Palmer
The use of functional fillers can be advantageous in terms of cost reduction and improved properties in plastics. There are many types of fillers used in industry, organic and inorganic, with a wide application area. As a response to the growing concerns about environmental damage that plastics cause, recently fillers have started to be considered as a way to reduce it by decreasing the need for petrochemical resources. Life cycle assessment (LCA) is identified as a proper tool to evaluate potential environmental impacts of products or systems...
June 1, 2018: Science of the Total Environment
Paula Quinteiro, Sandra Rafael, Pedro Villanueva-Rey, Bradley Ridoutt, Myriam Lopes, Luís Arroja, Ana Cláudia Dias
The development of methods to assess the potential environmental impact of green water consumption in life cycle assessment has lagged behind those for blue water use, which are now routinely applied in industrial and policy-related studies. This represents a critical gap in the assessment of land-based production systems and the ability to inform policy related to the bio-economy. Combining satellite remote sensing and meteorological data sets, this study develops two new sets of spatially-differentiated and globally applicable characterisation factors (CFs) to assess the environmental impact of green water flows in LCA...
June 1, 2018: Science of the Total Environment
Luz Garcia-Ceballos, Jose Ramon de Andres-Díaz, Miguel A Contreras-Lopez
The construction sector must advance in a more sustainable way and to achieve this goal, the application of global methodologies is needed. These methodologies should take into account all life stages of a building: planning, design, construction, use and demolition. The quantity and variety of the materials used in building construction condition the buildings' environmental and energy impacts. Life Cycle Assessment offers a standardized framework to evaluate the environmental loads of a product, process or activity...
June 1, 2018: Science of the Total Environment
Laura Roibás, Eléonore Loiseau, Almudena Hospido
Normalisation is an optional step in Life Cycle Assessment (LCA), often used in decision making since it helps interpreting the results of LCA studies with regard to some reference information. The applicable ISO standard recommends considering different reference systems to guarantee the robustness of the normalisation step, and so the availability of different normalisation datasets becomes of high relevance. Life Cycle Impact Assessment (LCIA) methods provide normalisation factors (NFs) for global and regional areas, but no NFs are proposed for smaller areas such as local or subnational scales...
June 1, 2018: Science of the Total Environment
Mary Vaughan Sarrazin, Gary E Rosenthal, Carolyn L Turvey
OBJECTIVE: Up to 70 percent of patients who receive care through Veterans Health Administration (VHA) facilities also receive care from non-VA providers. Using applied classification techniques, this study sought to improve understanding of how elderly VA patients use VA services and complementary use of non-VA care. METHODS: The study included 1,721,900 veterans age 65 and older who were enrolled in VA and Medicare during 2013 with at least one VA encounter during 2013...
June 12, 2018: Health Services Research
Thomas M Feltrup, Kruti Patel, Raj Kumar, Shuowei Cai, Bal Ram Singh
Botulinum neurotoxin (BoNT) is responsible for botulism, a clinical condition resulting in flaccid muscle paralysis and potentially death. The light chain is responsible for its intracellular toxicity through its endopeptidase activity. Available crystal structures of BoNT/A light chains (LCA) are based on various truncated versions (tLCA) of the full-length LCA (fLCA) and do not necessarily reflect the true structure of LCA in solution. The understanding of the mechanism of action, longevity of intoxication, and an improved development of endopeptidase inhibitors are dependent on first having a better insight into the structure of LCA in solution...
June 11, 2018: Scientific Reports
Larissa Terumi Arashiro, Neus Montero, Ivet Ferrer, Francisco Gabriel Acién, Cintia Gómez, Marianna Garfí
The aim of this study was to assess the potential environmental impacts associated with high rate algal ponds (HRAP) systems for wastewater treatment and resource recovery in small communities. To this aim, a Life Cycle Assessment (LCA) was carried out evaluating two alternatives: i) a HRAP system for wastewater treatment where microalgal biomass is valorized for energy recovery (biogas production); ii) a HRAP system for wastewater treatment where microalgal biomass is reused for nutrients recovery (biofertilizer production)...
May 1, 2018: Science of the Total Environment
Sally P Leys, Amanda S Kahn
The appearance of multicellular animals during the Neoproterozoic Era is thought to have coincided with oxygenation of the oceans, however we know little about the physiological needs of early animals or about the environment they lived in. Approaches using biomarkers, fossils, and phylogenomics have provided some hints of the types of animals that may have been present during the Neoproterozoic, but extant animals are our best modern links to the theoretical ancestors of animals. Neoproterozoic oceans were low energy habitats, with low oxygen concentrations and sparse food availability for the first animals...
June 7, 2018: Integrative and Comparative Biology
Seyed Mohammad Riahi, Soraya Moamer, Mahshid Namdari, Yaser Mokhayeri, Mohammad Amin Pourhoseingholi, Seyed Saeed Hashemi-Nazari
BACKGROUND: The Metabolic syndrome (MetS), refers to one of the most challenging public health issues across the world. The aim of this study was to explore the clusters of participants on the basis of MetS components and determine its effect on coronary heart disease (CHD). METHODS: This study used the information from Multi-Ethnic Study of Atherosclerosis (MESA). MESA was performed at 6 US sites and was a population-based cohort study of 6776 adults (3576 females; 3200 males), aged 45 to 84 years...
May 24, 2018: International Journal of Cardiology
Zuodong Qin, Mingxing Sun, Xiaofang Luo, Hongrui Zhang, Jiyong Xie, Haifeng Chen, Lirong Yang, Lei Shi
The aim of this work was to investigate the environmental performance of different tobacco stalk methods using Life Cycle Assessment (LCA). Three scenarios were established: biodegradable plant nursery tray (PNT) making, open burning, and indoor incineration. The results showed that 3380, 1590, 1320 kg CO2 -eq, 25.7, 1.97,1.99 kg SO2 -eq are generated for global warming and acidification in biodegradable PNT making, open burning, and indoor incineration scenarios respectively. The overall environmental impact for biodegradable PNT making is higher than that of open burning, and indoor incineration...
June 1, 2018: Bioresource Technology
Aikatarini Trantou, Hanne K Carlsen, Christina Anderson, Steinn Steingrimsson
OBJECTIVE: Determine sickness absence recommendation (SAR) prevalence for treatment-seeking patients with ADHD depending on comorbidity. METHOD: Population-based patient chart review of ADHD outpatients aged 19 to 29 years. The outcome, SAR, included both available financial benefit forms; activity compensation and sickness benefit. Latent class analyses (LCA) of demography and psychiatric comorbidities were performed both with and without SAR as an outcome variable...
June 1, 2018: Journal of Attention Disorders
Qing Zhao, Tian Zhu Jia, Qi Chen Cao, Fang Tian, Wan Tao Ying
The traditional Chinese drug Bombyx Batryticatus (BB), which is also named the white stiff silkworm, has been widely used in Chinese clinics for thousands of years. It is famous for its antispasmodic and blood circulation-promoting effects. Cardiomyocyte hypertrophy, interstitial cell hyperplasia, and myocardial fibrosis are closely related to the N -glycosylation of key proteins. To examine the alterations of N -glycosylation that occur in diabetic myocardium during the early stage of the disease, and to clarify the therapeutic effect of 1-Deoxynojirimycin (1-DNJ) extracted from BB, we used the db/db (diabetic) mouse model and an approach based on hydrophilic chromatography solid-phase extraction integrated with an liquid Chromatograph Mass Spectrometer (LC-MS) identification strategy to perform a site-specific N -glycosylation analysis of left ventricular cardiomyocyte proteins...
June 7, 2018: International Journal of Molecular Sciences
Natalia V Forosenko, Ivan V Basalov, Anton V Cherkasov, Georgy K Fukin, Elena S Shubina, Alexander A Trifonov
A series of amido Ca complexes LCa[N(SiMe3)2](THF) (1-4) coordinated by Schiff base ligands L1-4 were synthesized via an amine elimination reaction between proligands L1-4H and a bisamido complex Ca[N(SiMe3)2]2(THF)2 in good yield. Unlike Ca[N(SiMe3)2]2(THF)2, the reactions of M[N(SiMe3)2]2(THF)2 (M = Yb, Sm) with proligands L1-4H do not lead to the formation of the target Ln(ii) amido complexes. The reaction of Yb[N(SiMe3)2]2(THF)2 with L1H is accompanied by intramolecular C-H bond activation of a quinoline ring and results in the formation of complex 6 coordinated by a new trianionic [NNNNOO] ligand...
June 7, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
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