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https://www.readbyqxmd.com/read/27914352/searching-for-novel-modes-of-toxic-actions-of-oil-spill-using-e-%C3%A2-coli-live-cell-array-reporter-system-a-hebei-spirit-oil-spill-study
#1
Dawoon Jung, Miao Guan, Sangwoo Lee, Cheolmin Kim, Hyesoo Shin, Seongjin Hong, Un Hyuk Yim, Won Joon Shim, John P Giesy, Jong Seong Khim, Xiaowei Zhang, Kyungho Choi
Oil is a complex mixture of numerous compounds. Therefore, oil spills near shore can cause various adverse effects on coastal ecosystems. However, most toxicological assessments conducted on oil spill sites have focused on limited modes of toxic actions. In the present study, we utilized the Escherichia coli (E. coli) live cell array system (LCA) to identify novel modes of toxicities of the oil spill-affected sediments. For this purpose, sediment samples were collected from an area heavily polluted by Hebei Spirit oil spill (HSOS) incident of 2007...
November 30, 2016: Chemosphere
https://www.readbyqxmd.com/read/27910134/effectiveness-of-handmade-jacky-like-catheter-as-a-single-multipurpose-catheter-in-transradial-coronary-angiography-a-randomized-comparison-with-conventional-two-catheter-strategy
#2
Ismail Erden, Ebru Golcuk, Serdar Bozyel, Emine Cakcak Erden, Yakup Balaban, Kivanc Yalın, Burak Turan
OBJECTIVE: To investigate safety and efficacy of specialized hand-modified "Jacky-Like" catheter (JLC) as a single dual-purpose catheter in transradial coronary angiography. METHODS: Patients over 18 years undergoing diagnostic CAG through right radial artery (RRA) were prospectively enrolled. Procedures were performed with a single JLC modified from a left Judkins (JL) 3.5 catheter or by using 2-catheter approach (2C). Procedures with coronary artery bypass grafts or ventricular angiographies were excluded from the study...
December 2, 2016: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/27908290/bile-acid-a-potential-inducer-of-colon-cancer-stem-cells
#3
Lulu Farhana, Pratima Nangia-Makker, Evan Arbit, Kathren Shango, Sarah Sarkar, Hamidah Mahmud, Timothy Hadden, Yingjie Yu, Adhip P N Majumdar
BACKGROUND: Although the unconjugated secondary bile acids, specifically deoxycholic acid (DCA) and lithocholic acid (LCA), are considered to be risk factors for colorectal cancer, the precise mechanism(s) by which they regulate carcinogenesis is poorly understood. We hypothesize that the cytotoxic bile acids may promote stemness in colonic epithelial cells leading to generation of cancer stem cells (CSCs) that play a role in the development and progression of colon cancer. METHODS: Normal human colonic epithelial cells (HCoEpiC) were used to study bile acid DCA/LCA-mediated induction of CSCs...
December 1, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27907101/economic-and-environmental-impact-of-rice-blast-pathogen-magnaporthe-oryzae-alleviation-in-the-united-states
#4
Lawton Nalley, Francis Tsiboe, Alvaro Durand-Morat, Aaron Shew, Greg Thoma
Rice blast (Magnaporthe oryzae) is a key concern in combating global food insecurity given the disease is responsible for approximately 30% of rice production losses globally-the equivalent of feeding 60 million people. These losses increase the global rice price and reduce consumer welfare and food security. Rice is the staple crop for more than half the world's population so any reduction in rice blast would have substantial beneficial effects on consumer livelihoods. In 2012, researchers in the US began analyzing the feasibility of creating blast-resistant rice through cisgenic breeding...
2016: PloS One
https://www.readbyqxmd.com/read/27898927/effect-of-feeding-strategy-on-environmental-impacts-of-pig-fattening-in-different-contexts-of-production-evaluation-through-life-cycle-assessment
#5
A N T R Monteiro, F Garcia-Launay, L Brossard, A Wilfart, J-Y Dourmad
Life cycle assessment (LCA) has been used in many studies to evaluate the effect of feeding strategy on the environmental impact of pig production. However, because most studies have been conducted in European conditions, the question of possible interactions with the context of production is still under debate. The objective of this study was to evaluate these effects in 2 contrasted geographic contexts of production, South America (Brazil) and Europe (France). The LCA considered the process of pig fattening, including production and transport of feed ingredients and feed, raising of fattening pigs, and manure storage, transport, and spreading...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27896021/lithocholic-acid-induces-endoplasmic-reticulum-stress-autophagy-and-mitochondrial-dysfunction-in-human-prostate-cancer-cells
#6
Ahmed A Gafar, Hossam M Draz, Alexander A Goldberg, Mohamed A Bashandy, Sayed Bakry, Mahmoud A Khalifa, Walid AbuShair, Vladimir I Titorenko, J Thomas Sanderson
Lithocholic acid (LCA) is a secondary bile acid that is selectively toxic to human neuroblastoma, breast and prostate cancer cells, whilst sparing normal cells. We previously reported that LCA inhibited cell viability and proliferation and induced apoptosis and necrosis of androgen-dependent LNCaP and androgen-independent PC-3 human prostate cancer cells. In the present study, we investigated the roles of endoplasmic reticulum (ER) stress, autophagy and mitochondrial dysfunction in the toxicity of LCA in PC-3 and autophagy deficient, androgen-independent DU-145 cells...
2016: PeerJ
https://www.readbyqxmd.com/read/27895315/identification-of-aberrantly-expressed-glycans-in-gastric-cancer-by-integrated-lectin-microarray-and-mass-spectrometric-analyses
#7
Xiang Li, Feng Guan, Dongliang Li, Zengqi Tan, Ganglong Yang, Yanli Wu, Zhaohui Huang
Cancer progression is usually associated with alterations of glycan expression patterns. Little is known regarding global glycomics in gastric cancer, the most common type of epithelial cancer. We integrated lectin microarray and mass spectrometry (MS) methods to profile glycan expression in three gastric cancer cell lines (SGC-7901, HGC-27, and MGC-803) and one normal gastric epithelial cell line (GES-1). Significantly altered glycans were confirmed by lectin staining and MALDI-TOF/TOF-MS. The three cancer cell lines showed increased levels of core-fucosylated N-glycans, GalNAcα-Ser/Thr (Tn antigen), and Sia2-6Galβ1-4GlcNAc N-glycans, but reduced levels of biantennary N-glycans, Galβ1-3GalNAcα-Ser/Thr (T antigen), and (GlcNAc)n N-glycans...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27891328/abnormal-course-of-right-coronary-artery-together-with-variant-left-coronary-artery-and-partial-atresia-of-cicumflex-artery
#8
Rajani Singh
Heart is supplied by right and left coronary arteries. Therefore, the knowledge of normal and variant anatomy of both these arteries and their configurations is indispensable for proper understanding of diagnosis and treatment of dreaded cardiac diseases. During routine cadaveric dissection, a heart of an adult female with anomalous course of Right Coronary Artery (RCA), new variant of trifurcated Left Coronary Artery (LCA) and partial atresia of circumflex (CX) artery was detected. Trifurcation of LCA into anterior interventricular, CX and a ramus intermedius without giving accessory branches has been reported...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27888615/unconjugated-secondary-bile-acids-activate-the-unfolded-protein-response-and-induce-golgi-fragmentation-via-a-src-kinase-dependant-mechanism
#9
Ruchika Sharma, Francis Quilty, John F Gilmer, Aideen Long, Anne-Marie Byrne
Bile acids are components of gastro-duodenal refluxate and regarded as causative agents in oesophageal disease but the precise mechanisms are unknown. Here we demonstrate that a specific subset of physiological bile acids affect the protein secretory pathway by inducing ER stress, activating the Unfolded Protein Response (UPR) and causing disassembly of the Golgi apparatus in oesophageal cells. Deoxycholic acid (DCA), Chemodeoxycholic acid (CDCA) and Lithocholic acid (LCA) activated the PERK arm of the UPR, via phosphorylation of eIF2α and up-regulation of ATF3, CHOP and BiP/GRP78...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27880076/correlation-of-ultra-widefield-fundus-autofluorescence-patterns-with-the-underlying-genotype-in-retinal-dystrophies-and-retinitis-pigmentosa
#10
George Trichonas, Elias I Traboulsi, Justis P Ehlers
PURPOSE: Ultra-widefield fundus autofluorescence (UW-FAF) allows the characterization of the peripheral retinal features of vitreoretinal diseases. The purpose of this study was to examine possible genotypic/phenotypic correlations of UW-FAF patterns in patients with a variety of retinal dystrophies and retinitis pigmentosa (RP). METHODS: An IRB-approved retrospective consecutive case series study was performed of genetically characterized retinal dystrophy or RP patients who underwent UW-FAF imaging...
November 23, 2016: Ophthalmic Genetics
https://www.readbyqxmd.com/read/27873115/life-cycle-assessment-of-cheese-production-process-in-a-small-sized-dairy-industry-in-brazil
#11
Hudson Carlos Maia Santos, Henrique Leonardo Maranduba, José Adolfo de Almeida Neto, Luciano Brito Rodrigues
Current research identifies, analyzes, and suggests improvements for minimizing environmental impacts in the manufacture of cheese using the life cycle assessment. Data collection and development of the inventory were performed in a small-sized dairy industry in Brazil. A cradle-to-gate approach was conducted based on the primary data from cheese production and secondary data from databases. The ReCiPe method was used for the impact assessment, considering the categories climate change, ozone depletion, terrestrial acidification, freshwater eutrophication, photochemical oxidant formation, particulate matter formation, water depletion, and fossil depletion...
November 21, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27873006/feasibility-of-omitting-provocation-test-with-50%C3%A2-%C3%AE-g-of-acetylcholine-in-left-coronary-artery
#12
Yuichi Saito, Hideki Kitahara, Toshihiro Shoji, Satoshi Tokimasa, Takashi Nakayama, Kazumasa Sugimoto, Yoshihide Fujimoto, Yoshio Kobayashi
According to the Japanese Circulation Society guideline of vasospastic angina, incremental doses of acetylcholine (ACh) are prescribed for coronary spasm provocation: 20 and 50 μg for the right coronary artery (RCA), and 20, 50 and 100 μg for the left coronary artery (LCA). However, provocation by low doses of ACh in patients with low vasoreactivity may be less needed, and the requirement of 50 μg of ACh for the LCA in these patients has not been evaluated. In the present study, patients who underwent ACh provocation test for both the RCA and LCA were included...
November 21, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27871908/acetylated-deoxycholic-dca-and-cholic-ca-acids-are-potent-ligands-of-pregnane-x-pxr-receptor
#13
Alejandro Carazo, Lucie Hyrsova, Jan Dusek, Hana Chodounska, Alzbeta Horvatova, Karel Berka, Vaclav Bazgier, Hongying Gan-Schreier, Waleé Chamulitrat, Eva Kudova, Petr Pavek
The Pregnane X (PXR), Vitamin D (VDR) and Farnesoid X (FXR) nuclear receptors have been shown to be receptors of bile acids controlling their detoxification or synthesis. Chenodeoxycholic (CDCA) and lithocholic (LCA) acids are ligands of FXR and VDR, respectively, whereas 3-keto and acetylated derivates of LCA have been described as ligands for all three receptors. In this study, we hypothesized that oxidation or acetylation at position 3, 7 and 12 of bile acids DCA (deoxycholic acid), LCA, CA (cholic acid), and CDCA by detoxification enzymes or microbiome may have an effect on the interactions with bile acid nuclear receptors...
November 18, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27871639/international-comparisons-of-the-youth-self-report-dysregulation-profile-latent-class%C3%A2-analyses-in-34-societies
#14
Phoebe Jordan, Leslie A Rescorla, Robert R Althoff, Thomas M Achenbach
OBJECTIVE: We used latent class analysis (LCA) to examine the prevalence and characteristics of the Dysregulation Profile (DP) based on data from the Youth Self-Report (YSR). The DP comprises elevated scores on the Anxious/Depressed, Attention Problems, and Aggressive Behavior syndromes and thus reflects significant problems in self-regulation of affect, attention, and behavior. METHOD: We examined YSR data for 38,070 adolescents (48.1% male) in 34 societies. Participants ranged in age from 11 to 16 years...
December 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27866931/key-role-of-endothelium-in-the-enos-dependent-cardioprotection-with-exercise-training
#15
C Farah, A Nascimento, G Bolea, G Meyer, S Gayrard, A Lacampagne, O Cazorla, C Reboul
Modulation of endothelial nitric oxide synthase (eNOS) activation is recognized as a main trigger of the cardioprotective effects of exercise training on heart vulnerability to ischemia-reperfusion (IR). However, this enzyme is expressed both in coronary endothelial cells and cardiomyocytes and the contribution of each one to such cardioprotection has never been challenged. The aim of this study was to investigate the role of eNOS from the cardiomyocytes vs. the endothelium in the exercise cardioprotection...
November 17, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27866046/changes-in-depression-among-older-adults-in-china-a-latent-transition-analysis
#16
Yuhan Ni, Jenn-Yun Tein, Minqiang Zhang, Yawei Yang, Guoting Wu
BACKGROUND: Depression in late life is an important public health problem in developing countries. It is timely to investigate stability and transition patterns of depressive symptom subtypes. METHODS: Longitudinal data were used from the China Health and Retirement Longitudinal Study (CHARLS). A total of 853 women and 930 men aged 60-96 years were recruited. Latent class and latent transition analysis (LCA/LTA) were used to identify meaningful subgroups, transitions between those classes across time, and baseline demographic features that help to predict and design tailored interventions...
November 15, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27864735/environmental-analysis-of-waste-foundry-sand-via-life-cycle-assessment
#17
Jozef Mitterpach, Emília Hroncová, Juraj Ladomerský, Karol Balco
The aim of this manuscript is to provide an environmental assessment of the creation and use of waste foundry sand (WFS) via an LCA in a foundry for grey cast iron. A life cycle impact assessment was carried out using SimaPro 8. This environmental analysis assessed the impact of creating waste foundry sand (WFS) in a foundry, Hronec (Slovakia, Central Europe). According to BREF, this foundry is classified as an iron foundry with a production capacity greater than 20 t/day with processes typical for grey cast iron foundries...
November 18, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27847477/reverse-of-acute-and-chronic-morphine-tolerance-by-lithocholic-acid-via-down-regulating-ugt2b7
#18
Zizhao Yang, Li Li, Haihong Hu, Mingcheng Xu, Jingkai Gu, Zaijie Jim Wang, Lushan Yu, Su Zeng
Lithocholic acid (LCA) deposited in human livers always induces drastic pains which need analgesic drug, like morphine to release. Our research showed that LCA can effectively inhibit uridine 5'-diphospho-glucuronosyltransferase 2B7 (UGT2B7) in morphine tolerance-like human normal liver cells, HL-7702, then increase μ-opioid receptor (MOR) and calcium-calmodulin dependent protein kinase IIα (CaMKIIα) expression. In vivo assay, UGT2B7 was significantly repressed in the livers of acute or chronic morphine tolerance mice pretreated with LCA (10, 50, and 100 mg/kg, p...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27845549/assets-as-a-socioeconomic-status-index-categorical-principal-components-analysis-vs-latent-class-analysis
#19
Majid Sartipi, Saharnaz Nedjat, Mohammad Ali Mansournia, Vali Baigi, Akbar Fotouhi
BACKGROUND: Some variables like Socioeconomic Status (SES) cannot be directly measured, instead, so-called 'latent variables' are measured indirectly through calculating tangible items. There are different methods for measuring latent variables such as data reduction methods e.g. Principal Components Analysis (PCA) and Latent Class Analysis (LCA). OBJECTIVES: The purpose of our study was to measure assets index- as a representative of SES- through two methods of Non-Linear PCA (NLPCA) and LCA, and to compare them for choosing the most appropriate model...
November 2016: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/27844161/latent-classes-of-emotional-and-behavioural-problems-in-epidemiological-and-referred-samples-and-their-relations-to-dsm-iv-diagnoses
#20
Valentina Bianchi, Paolo Brambilla, Marco Garzitto, Paola Colombo, Livia Fornasari, Monica Bellina, Carolina Bonivento, Alessandra Tesei, Sara Piccin, Stefania Conte, Giampaolo Perna, Alessandra Frigerio, Isabella Castiglioni, Franco Fabbro, Massimo Molteni, Maria Nobile
Researchers' interest have recently moved toward the identification of recurrent psychopathological profiles characterized by concurrent elevations on different behavioural and emotional traits. This new strategy turned to be useful in terms of diagnosis and outcome prediction. We used a person-centred statistical approach to examine whether different groups could be identified in a referred sample and in a general-population sample of children and adolescents, and we investigated their relation to DSM-IV diagnoses...
November 14, 2016: European Child & Adolescent Psychiatry
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