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https://www.readbyqxmd.com/read/29678441/acute-lymphoblastic-leukemia-lymphoma-of-the-oral-and-maxillofacial-region
#1
Celeste Sánchez-Romero, Hélder Antônio Rebelo Pontes, Flávia Sirotheau Corrêa Pontes, André Caroli Rocha, Román Carlos, Javier C Rendón, Oslei Paes de Almeida, Felipe Paiva Fonseca
OBJECTIVE: Our objective was to describe the clinicopathologic and immunohistochemical features of acute lymphoblastic leukemia/lymphoma (ALL/LBL) of the oral and maxillofacial region (OMF). STUDY DESIGN: Cases diagnosed as ALL/LBL of the OMF region were retrieved from the files of 2 Brazilian and 1 Guatemalan oral pathology services from 2005 to 2017. Microscopic and immunohistochemical features of each case were reviewed and fully described, and clinical data were retrieved from the pathology reports...
January 31, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29678199/megan-lr-new-algorithms-allow-accurate-binning-and-easy-interactive-exploration-of-metagenomic-long-reads-and-contigs
#2
Daniel H Huson, Benjamin Albrecht, Caner Bağcı, Irina Bessarab, Anna Górska, Dino Jolic, Rohan B H Williams
BACKGROUND: There are numerous computational tools for taxonomic or functional analysis of microbiome samples, optimized to run on hundreds of millions of short, high quality sequencing reads. Programs such as MEGAN allow the user to interactively navigate these large datasets. Long read sequencing technologies continue to improve and produce increasing numbers of longer reads (of varying lengths in the range of 10k-1M bps, say), but of low quality. There is an increasing interest in using long reads in microbiome sequencing, and there is a need to adapt short read tools to long read datasets...
April 20, 2018: Biology Direct
https://www.readbyqxmd.com/read/29675296/ultrahigh-resolution-retinal-imaging-by-visible-light-oct-with-longitudinal-achromatization
#3
Shau Poh Chong, Tingwei Zhang, Aaron Kho, Marcel T Bernucci, Alfredo Dubra, Vivek J Srinivasan
Chromatic aberrations are an important design consideration in high resolution, high bandwidth, refractive imaging systems that use visible light. Here, we present a fiber-based spectral/Fourier domain, visible light OCT ophthalmoscope corrected for the average longitudinal chromatic aberration (LCA) of the human eye. Analysis of complex speckles from in vivo retinal images showed that achromatization resulted in a speckle autocorrelation function that was ~20% narrower in the axial direction, but unchanged in the transverse direction...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29674290/the-impact-of-patterns-of-trauma-exposure-among-low-income-children-with-and-without-histories-of-child-maltreatment
#4
Abigail L Rosen, Elizabeth D Handley, Dante Cicchetti, Fred A Rogosch
Previous research has revealed a large prevalence of trauma experienced by children, creating high risk for the development of psychopathology. Research investigating the negative impacts of child maltreatment and other traumas has typically examined these experiences individually, controlling for co-occurring traumas, or has combined these experiences into a general variable of risk, thereby obscuring the complex relationships among environmental traumas and maltreatment. The current study expands on previous research by elucidating relationships between multiple contexts of overlapping traumas and maltreatment experienced by children, and by categorizing how these experiences join together to impact internalizing and externalizing symptomatology...
April 16, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29673930/amelioration-of-neurosensory-structure-and-function-in-animal-and-cellular-models-of-a-congenital-blindness
#5
Ji Yun Song, Puya Aravand, Sergei Nikonov, Lanfranco Leo, Arkady Lyubarsky, Jeannette L Bennicelli, Jieyan Pan, Zhangyong Wei, Ivan Shpylchak, Pamela Herrera, Daniel J Bennett, Nicoletta Commins, Albert M Maguire, Jennifer Pham, Anneke I den Hollander, Frans P M Cremers, Robert K Koenekoop, Ronald Roepman, Patsy Nishina, Shangzhen Zhou, Wei Pan, Gui-Shuang Ying, Tomas S Aleman, Jimmy de Melo, Ilan McNamara, Junwei Sun, Jason Mills, Jean Bennett
Most genetically distinct inherited retinal degenerations are primary photoreceptor degenerations. We selected a severe early onset form of Leber congenital amaurosis (LCA), caused by mutations in the gene LCA5, in order to test the efficacy of gene augmentation therapy for a ciliopathy. The LCA5-encoded protein, Lebercilin, is essential for the trafficking of proteins and vesicles to the photoreceptor outer segment. Using the AAV serotype AAV7m8 to deliver a human LCA5 cDNA into an Lca5 null mouse model of LCA5, we show partial rescue of retinal structure and visual function...
March 21, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29667059/energy-and-environmental-impact-analysis-of-rice-cultivation-and-straw-management-in-northern-thailand
#6
Sanwasan Yodkhum, Sate Sampattagul, Shabbir H Gheewala
Rice cultivation and energy use for rice production can produce the environmental impacts, especially related to greenhouse gas (GHG) emissions. Also, rice straw open burning by farmers generally practiced after harvesting stage in Thailand for removing the residues in the rice field is associated with emissions of air pollutants, especially particulate matter formation that affects human health and global climate. This study assessed the environmental burdens, consisting of GHG emissions, energy use, and particulate matter formation (PM10), from rice cultivation in Thailand by life cycle assessment (LCA) and compared the environmental burdens of rice straw management scenarios: open burning, incorporation into soil, and direct combustion for electricity generation...
April 17, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29666996/comparison-of-t2-relaxation-values-in-subtalar-cartilage-between-patients-with-lateral-instability-of-the-ankle-joint-and-healthy-volunteers
#7
Hyun Su Kim, Young Cheol Yoon, Ki Sun Sung, Min-Ji Kim, Soohyun Ahn
PURPOSE: To evaluate the difference between T2 relaxation values of the subtalar cartilage in lateral ankle instability patients and healthy volunteers. MATERIALS AND METHODS: This institutional review board-approved study included 27 preoperative magnetic resonance imaging (MRI) examinations of 26 patients who underwent Broström operations. Data of previously enrolled healthy volunteers (12 volunteers, 13 MRIs) were used as controls. Two radiologists independently measured T2 values in eight posterior subtalar joint cartilage compartments: central calcaneus anterior (CCA) and posterior (CCP), central talus anterior (CTA) and posterior (CTP), lateral calcaneus anterior (LCA) and posterior (LCP), and lateral talus anterior (LTA) and posterior (LTP)...
April 17, 2018: European Radiology
https://www.readbyqxmd.com/read/29665546/expansion-of-environmental-impact-assessment-for-eco-efficiency-evaluation-of-china-s-economic-sectors-an-economic-input-output-based-frontier-approach
#8
Zhencheng Xing, Jigan Wang, Jie Zhang
Due to the increasing environmental burdens caused by dramatic economic expansion, eco-efficiency indicating how efficient the economic activity is with respect to its environmental impacts has become a topic of considerable interest in China. In this context, Economic Input-output Life Cycle Assessment (EIO-LCA) and Data Envelopment Analysis (DEA) are combined to assess the environmental impacts and eco-efficiency of China's 26 economic sectors. The EIO-LCA results indicate that Electricity Production and Supply sector is the largest net exporter in energy usage, CO2 emission and exhaust emission categories, while Construction sector is the largest net importer for five impact categories except for water withdrawal...
April 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29664215/the-plasma-bile-acid-alterations-of-type-2-diabetes-correlated-with-insulin-secretion-in-two-step-hyperglycemic-clamp
#9
Shujie Wang, Yuying Deng, Xiaoyan Xie, Jing Ma, Min Xu, Xinjie Zhao, Weiqiong Gu, Jie Hong, Weiqing Wang, Guowang Xu, Guang Ning, Yanyun Gu, Yifei Zhang
BACKGROUND: Bile acids (BAs) conduct crucial signals in human metabolism. Correlations between human plasma BA alterations and insulin secretion defects and type 2 diabetes (T2D) progression have been insufficiently studied. This study was performed to explore the trajectories of human plasma BA alterations and their association with the insulin secretion dynamics during a two-step hyperglycemic clamp. METHODS: Eleven healthy (NGT) and 33 drug-naïve T2D subjects (T2Ds) were enrolled to undertake a two-step hyperglycemic clamp...
April 17, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29661582/parents-preferences-for-interventions-to-improve-childhood-immunization-uptake-in-northern-nigeria
#10
Sachiko Ozawa, Mo Zhou, Chizoba Wonodi, Hui-Han Chen, John F P Bridges
BACKGROUND: Routine childhood immunization coverage has been low in northern Nigeria. While local authorities and international partners have been working hard to improve coverage, population preferences for interventions have not been documented. This study aimed to understand parents' preferences and identify possible interventions to improve uptake of childhood immunization. METHODS: Preferences for immunization interventions were elicited using a best-worst scaling (BWS) instrument among parents with children under five...
April 13, 2018: Vaccine
https://www.readbyqxmd.com/read/29660720/environmental-impact-of-cheese-production-a-case-study-of-a-small-scale-factory-in-southern-europe-and-global-overview-of-carbon-footprint
#11
Fernando Canellada, Amanda Laca, Adriana Laca, Mario Díaz
The environmental performance of a small-scale cheese factory sited in a NW Spanish region has been analysed by Life Cycle Assessment (LCA) as representative of numerous cheese traditional factories that are scattered through the European Union, especially in the southern countries. Inventory data were directly obtained from this facility corresponding to one-year operation, and the main subsystems involved in cheese production were included, i.e. raw materials, water, electricity, energy, cleaning products, packaging materials, transports, solid and liquid wastes and gas emissions...
April 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29660714/techno-environmental-assessment-of-the-green-biorefinery-concept-combining-process-simulation-and-life-cycle-assessment-at-an-early-design-stage
#12
Andrea Corona, Morten Ambye-Jensen, Giovanna Croxatto Vega, Michael Zwicky Hauschild, Morten Birkved
The Green biorefinery (GBR) is a biorefinery concept that converts fresh biomass into value-added products. The present study combines a Process Flowsheet Simulation (PFS) and Life Cycle Assessment (LCA) to evaluate the technical and environmental performance of different GBR configurations and the cascading utilization of the GBR output. The GBR configurations considered in this study, test alternatives in the three main steps of green-biorefining: fractionation, precipitation, and protein separation. The different cascade utilization alternatives analyse different options for press-pulp utilization, and the LCA results show that the environmental profile of the GBR is highly affected by the utilization of the press-pulp and thus by the choice of conventional product replaced by the press-pulp...
April 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29660709/a-simplified-approach-to-determine-the-carbon-footprint-of-a-region-key-learning-points-from-a-galician-study
#13
Laura Roibás, Eléonore Loiseau, Almudena Hospido
On a previous study, the carbon footprint (CF) of all production and consumption activities of Galicia, an Autonomous Community located in the north-west of Spain, was determined and the results were used to devise strategies aimed at the reduction and mitigation of the greenhouse gas (GHG) emissions. The territorial LCA methodology was used there to perform the calculations. However, that methodology was initially designed to compute the emissions of all types of polluting substances to the environment (several thousands of substances considered in the life cycle inventories), aimed at performing complete LCA studies...
April 13, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29656257/nutrient-derived-environmental-impacts-in-chinese-agriculture-during-1978-2015
#14
Huijun Wu, Shun Wang, Liangmin Gao, Ling Zhang, Zengwei Yuan, Tingyu Fan, Kaiping Wei, Li Huang
Nitrogen (N) and phosphorus (P) play a critical role in agricultural production and cause many environmental disturbances. By combing life cycle assessment (LCA) method with the mass balance principle of substance flow analysis (SFA), this study establishes a nutrient-derived environmental impact assessment (NEIA) model to analyze the environmental impacts caused by nutrient-containing substances of agricultural production in China during 1978-2015. The agricultural production system is composed of crop farming and livestock breeding, and the environmental impacts include energy consumption, global warming, acidification, and eutrophication...
April 12, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29656109/bile-acids-are-important-direct-and-indirect-regulators-of-the-secretion-of-appetite-and-metabolism-regulating-hormones-from-the-gut-and-pancreas
#15
Rune E Kuhre, Nicolai J Wewer Albrechtsen, Olav Larsen, Sara L Jepsen, Emilie Balk-Møller, Daniel B Andersen, Carolyn F Deacon, Kristina Schoonjans, Frank Reimann, Fiona M Gribble, Reidar Albrechtsen, Bolette Hartmann, Mette M Rosenkilde, Jens J Holst
OBJECTIVE: Bile acids (BAs) facilitate fat absorption and may play a role in glucose and metabolism regulation, stimulating the secretion of gut hormones. The relative importance and mechanisms involved in BA-stimulated secretion of appetite and metabolism regulating hormones from the gut and pancreas is not well described and was the purpose of this study. METHODS: The effects of bile acids on the secretion of gut and pancreatic hormones was studied in rats and compared to the most well described nutritional secretagogue: glucose...
March 17, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29655782/lithocholic-acid-a-bacterial-metabolite-reduces-breast-cancer-cell-proliferation-and-aggressiveness
#16
Edit Mikó, András Vida, Tünde Kovács, Gyula Ujlaki, György Trencsényi, Judit Márton, Zsanett Sári, Patrik Kovács, Anita Boratkó, Zoltán Hujber, Tamás Csonka, Péter Antal-Szalmás, Mitsuhiro Watanabe, Imre Gombos, Balazs Csoka, Borbála Kiss, László Vígh, Judit Szabó, Gábor Méhes, Anna Sebestyén, James J Goedert, Péter Bai
Our study aimed at finding a mechanistic relationship between the gut microbiome and breast cancer. Breast cancer cells are not in direct contact with these microbes, but disease could be influenced by bacterial metabolites including secondary bile acids that are exclusively synthesized by the microbiome and known to enter the human circulation. In murine and bench experiments, a secondary bile acid, lithocholic acid (LCA), reduced cancer cell proliferation (by 10-20%) and VEGF production (by 37%), aggressiveness and metastatic potential of primary tumors through inducing mesenchymal-to-epithelial transition, increased antitumor immune response, OXPHOS and the TCA cycle...
April 12, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29652945/clinical-evaluation-and-validation-of-laboratory-methods-for-the-diagnosis-of-bordetella-pertussis-infection-culture-polymerase-chain-reaction-pcr-and-anti-pertussis-toxin-igg-serology-igg-pt
#17
Adria D Lee, Pamela K Cassiday, Lucia C Pawloski, Kathleen M Tatti, Monte D Martin, Elizabeth C Briere, M Lucia Tondella, Stacey W Martin
INTRODUCTION: The appropriate use of clinically accurate diagnostic tests is essential for the detection of pertussis, a poorly controlled vaccine-preventable disease. The purpose of this study was to estimate the sensitivity and specificity of different diagnostic criteria including culture, multi-target polymerase chain reaction (PCR), anti-pertussis toxin IgG (IgG-PT) serology, and the use of a clinical case definition. An additional objective was to describe the optimal timing of specimen collection for the various tests...
2018: PloS One
https://www.readbyqxmd.com/read/29651686/tackling-the-relevance-of-packaging-in-life-cycle-assessment-of-virgin-olive-oil-and-the-environmental-consequences-of-regulation
#18
Alejandra Navarro, Rita Puig, Elena Martí, Alba Bala, Pere Fullana-I-Palmer
Production and consumption of olive oil is very important in Europe, being this product a basic element in the Mediterranean diet since long ago. The project objective is two-fold: a study of the contribution of virgin olive oils (VOOs) usual packaging to the whole life cycle of the product and a study of the environmental consequences of the Spanish Government regulation on VOO packaging. A life cycle assessment (LCA) according to ISO 14044 has been performed using the CML methodology for the impact assessment...
April 12, 2018: Environmental Management
https://www.readbyqxmd.com/read/29648597/secondary-bile-acids-inhibit-candida-albicans-growth-and-morphogenesis
#19
Jack Guinan, Pedro Villa, Shankar Thangamani
Candida albicans is one of the most common causes of fungal infections in humans with a significant mortality rate. However, the factors involved in C. albicans gastrointestinal (GI) colonization remain unclear. We hypothesize that secondary bile acids have direct antifungal activity against C. albicans and may play a critical role in maintaining GI colonization resistance against C. albicans. In this study, we investigated the effect of secondary bile acids including lithocholic acid (LCA) and deoxycholic acid (DCA) on C...
April 10, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29627535/environmental-and-sustainability-evaluation-of-livestock-waste-management-practices-in-cyprus
#20
Lucía Lijó, Nicola Frison, Francesco Fatone, Sara González-García, Gumersindo Feijoo, Maria Teresa Moreira
The aim of this study was to compare the environmental performance and sustainability of different management options for livestock waste in Cyprus. The two most common practices in the country, i.e. the use of anaerobic lagoons and conventional biogas plants, were compared with the innovative scheme developed in the LiveWaste project (LIFE12 ENV/CY/000544), which aims not only to produce bioenergy, but also to treat the digestate for nutrient recovery and water reuse. The Life Cycle Assessment (LCA) methodology was combined with the Analytic Hierarchy Process (AHP) to compare the performance of these alternatives...
April 5, 2018: Science of the Total Environment
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