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https://www.readbyqxmd.com/read/29468481/licarin-a-induces-cell-death-by-activation-of-autophagy-and-apoptosis-in-non-small-cell-lung-cancer-cells
#1
Uma Maheswari, Krishna Ghosh, Sudha Rani Sadras
Lung cancer has a relatively poor prognosis with a low survival rate and drugs that target other cell death mechanism like autophagy may help improving current therapeutic strategy. This study investigated the anti-proliferative effect of Licarin A (LCA) from Myristica fragrans in non-small cell lung cancer cell lines-A549, NCI-H23, NCI-H520 and NCI-H460. LCA inhibited proliferation of all the four cell lines in a dose and time dependent manner with minimum IC50 of 20.03 ± 3.12, 22.19 ± 1.37 µM in NCI-H23 and A549 cells respectively...
February 21, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29467107/associations-between-personal-care-product-use-patterns-and-breast-cancer-risk-among-white-and-black-women-in-the-sister-study
#2
Kyla W Taylor, Melissa A Troester, Amy H Herring, Lawrence S Engel, Hazel B Nichols, Dale P Sandler, Donna D Baird
BACKGROUND: Many personal care products include chemicals that might act as endocrine disruptors and thus increase the risk of breast cancer. OBJECTIVE: We examined the association between usage patterns of beauty, hair, and skin-related personal care products and breast cancer incidence in the Sister Study, a national prospective cohort study (enrollment 2003-2009). METHODS: Non-Hispanic black (4,452) and white women (n=42,453) were examined separately using latent class analysis (LCA) to identify groups of individuals with similar patterns of self-reported product use in three categories (beauty, skin, hair)...
February 21, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29456293/critical-review-of-elementary-flows-in-lca-data
#3
Ashley Edelen, Wesley W Ingwersen, Cristina Rodríguez, Rodrigo A F Alvarenga, Artur Ribeiro de Almeida, Gregor Wernet
Purpose: Elementary flows are essential components of data used for life cycle assessment. A standard list is not used across all sources, as data providers now manage these flows independently. Elementary flows must be consistent across a life cycle inventory for accurate inventory analysis and must correspond with impact methods for impact assessment. With the goal of achieving a global network of LCA databases, a critical review of elementary flow usage and management in LCA data sources was performed...
July 1, 2017: International Journal of Life Cycle Assessment
https://www.readbyqxmd.com/read/29454817/investigating-the-feasibility-of-a-reuse-scenario-for-textile-fibres-recovered-from-end-of-life-tyres
#4
Daniele Landi, Silvia Gigli, Michele Germani, Marco Marconi
The management of end-of-life tyres (ELTs) is regulated by several national and international legislations aiming to promote the recovery of materials and energy from this waste. The three main materials used in tyres are considered: rubber (main product), which is currently reused in other closed-loop applications; steel, which is used for the production of virgin materials; and textile fibres (approximately 10% by weight of ELTs), which are mainly incinerated for energy recovery (open-loop scenario). This study aims to propose and validate a new closed-loop scenario for textile fibres based on material reuse for bituminous conglomerates...
February 14, 2018: Waste Management
https://www.readbyqxmd.com/read/29454227/a-pilot-trial-of-l-carnitine-in-patients-with-traumatic-brain-injury-effects-on-biomarkers-of-injury
#5
Ata Mahmoodpoor, Ghaffar Shokouhi, Hadi Hamishehkar, Hassan Soleimanpour, Sarvin Sanaie, Jahan Porhomayon, Fatemeh Rasouli, Nader D Nader
OBJECTIVE: To investigate the effects of l-Carnitine on neuron specific enolase (NSE) as a marker of inflammation in patients with traumatic brain injury (TBI). METHODS: Forty patients with severe TBI were randomized into 2 groups. The (LCA-) group received standard treatment with placebo while the (LCA+) group received l-Carnitine 2g/day for one week. NSE was measured on days 1, 3 and 7 after the initiation of the study. Neurocognitive and neurobehavioral disorders were recorded on the first and third months...
February 9, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29451887/evaluating-diagnostic-indicators-of-urogenital-schistosoma-haematobium-infection-in-young-women-a-cross-sectional-study-in-rural-south-africa
#6
Hashini Nilushika Galappaththi-Arachchige, Sigve Holmen, Artemis Koukounari, Elisabeth Kleppa, Pavitra Pillay, Motshedisi Sebitloane, Patricia Ndhlovu, Lisette van Lieshout, Birgitte Jyding Vennervald, Svein Gunnar Gundersen, Myra Taylor, Eyrun Floerecke Kjetland
BACKGROUND: Urine microscopy is the standard diagnostic method for urogenital S. haematobium infection. However, this may lead to under-diagnosis of urogenital schistosomiasis, as the disease may present itself with genital symptoms in the absence of ova in the urine. Currently there is no single reliable and affordable diagnostic method to diagnose the full spectrum of urogenital S. haematobium infection. In this study we explore the classic indicators in the diagnosis of urogenital S...
2018: PloS One
https://www.readbyqxmd.com/read/29450543/mutation-in-the-zebrafish-cct2-gene-leads-to-abnormalities-of-cell-cycle-and-cell-death-in-the-retina-a-model-of-cct2-related-leber-congenital-amaurosis
#7
Yuriko Minegishi, Naoki Nakaya, Stanislav I Tomarev
Purpose: The compound heterozygous mutations in the β subunit of chaperonin containing TCP-1 (CCT), encoded by CCT2, lead to the Leber congenital amaurosis (LCA). In this study, a cct2 mutant line of zebrafish was established to investigate the role of CCT2 mutations in LCA in vertebrates. Methods: A cct2 mutant zebrafish line was produced using the CRISPR-Cas9 system. Changes in the eyes of developing wild-type and mutant larvae were monitored using microscopy, immunostaining, TUNEL, and EdU assays...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29446302/life-cycle-assessment-of-connected-and-automated-vehicles-sensing-and-computing-subsystem-and-vehicle-level-effects
#8
James H Gawron, Gregory A Keoleian, Robert D De Kleine, Timothy J Wallington, Hyung Chul Kim
Although recent studies of connected and automated vehicles (CAVs) have begun to explore the potential energy and greenhouse gas (GHG) emission impacts from an operational perspective, little is known about how the full life cycle of the vehicle will be impacted. We report the results of a life cycle assessment (LCA) of Level 4 CAV sensing and computing subsystems integrated into internal combustion engine vehicle (ICEV) and battery electric vehicle (BEV) platforms. The results indicate that CAV subsystems could increase vehicle primary energy use and GHG emissions by 3-20% due to increases in power consumption, weight, drag, and data transmission...
February 15, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29427579/protective-effects-of-yangonin-from-an-edible-botanical-kava-against-lithocholic-acid-induced-cholestasis-and-hepatotoxicity
#9
Yulong Kong, Xiaoguang Gao, Changyuan Wang, Chenqing Ning, Kexin Liu, Zhihao Liu, Huijun Sun, Xiaodong Ma, Pengyuan Sun, Qiang Meng
Accumulation of toxic bile acids in liver could cause cholestasis and liver injury. The purpose of the current study is to evaluate the hepatoprotective effect of yangonin, a product isolated from an edible botanical Kava against lithocholic acid (LCA)-induced cholestasis, and further to elucidate the involvement of farnesoid X receptor (FXR) in the anticholestatic effect using in vivo and in vitro experiments. The cholestatic liver injury model was established by intraperitoneal injections of LCA in C57BL/6 mice...
February 7, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29427544/pediatric-nurses-perceived-knowledge-and-beliefs-of-evidence-based-practice-in-the-care-of-children-and-adolescents-with-moderate-to-severe-traumatic-brain-injury
#10
Tolu O Oyesanya, Traci R Snedden
PURPOSE: Pediatric nurses play a significant role in all phases of traumatic brain injury (TBI) recovery, particularly during the hospital stay. Although evidence-based nursing practice is known to improve patient outcomes, limited research exists on nurses' evidence-based perceived knowledge and beliefs specific to TBI care. As nurses' perceived knowledge and beliefs are known to guide their practice behaviors, this assessment is important to overall TBI outcomes. The purpose of this study was to evaluate pediatric nurses' evidence-based perceived knowledge and beliefs in providing care for children and adolescents with moderate-to-severe TBI...
February 10, 2018: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/29426224/shelf-life-extension-as-solution-for-environmental-impact-mitigation-a-case-study-for-bakery-products
#11
Jacopo Bacenetti, Alessia Cavaliere, Giacomo Falcone, Valentina Giovenzana, Alessandro Banterle, Riccardo Guidetti
Over the last years, increasing attention has been paid to environmental concerns related to food production and potential solutions to this issue. Among the different strategies being considered to reduce the impact food production has on the environment, only moderate has been paid to the extension of shelf life; a longer shelf life can reduce food losses as well as the economic and environmental impacts of the distribution logistics. The aim of this study is to assess the environmental performance of whole-wheat breadsticks with extended shelf lives and to evaluate whether the shelf-life extension is an effective mitigation solution from an environmental point of view...
February 2, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29426132/life-cycle-analysis-of-a-new-modular-greening-system
#12
Maria Manso, João Castro-Gomes, Bárbara Paulo, Isabel Bentes, Carlos Afonso Teixeira
The construction and use of buildings represent about half of the extracted materials and energy consumption, and around one third of the water consumption and waste produced in the European Union. Therefore it is becoming more important to use sustainable materials that reduce the environmental impacts of construction, by conserving and using resources more efficiently. Green walls can be used as a sustainable strategy to reduce the environmental impact of buildings. The aim of this study is to evaluate the environmental impact of a new modular system for green roofs and green walls (Geogreen) which uses waste and sustainable materials in its composition...
February 5, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29424559/bayesian-latent-class-analysis-tutorial
#13
Yuelin Li, Jennifer Lord-Bessen, Mariya Shiyko, Rebecca Loeb
This article is a how-to guide on Bayesian computation using Gibbs sampling, demonstrated in the context of Latent Class Analysis (LCA). It is written for students in quantitative psychology or related fields who have a working knowledge of Bayes Theorem and conditional probability and have experience in writing computer programs in the statistical language R . The overall goals are to provide an accessible and self-contained tutorial, along with a practical computation tool. We begin with how Bayesian computation is typically described in academic articles...
February 9, 2018: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/29417250/using-coronary-ct-angiography-for-guiding-invasive-coronary-angiography-potential-role-to-reduce-intraprocedural-radiation-exposure
#14
Christophe T Arendt, Patricia Tischendorf, Julian L Wichmann, Michael Messerli, Lucas Jörg, Niklas Ehl, Robin F Gohmann, Simon Wildermuth, Thomas J Vogl, Ralf W Bauer
OBJECTIVES: We investigated the potential reduction of patient exposure during invasive coronary angiography (ICA) if the procedure had only been directed to the vessel with at least one ≥ 50% stenosis as described in the CT report. METHODS: Dose reports of 61 patients referred to ICA because of at least one ≥ 50% stenosis on coronary CT angiography (CCTA) were included. Dose-area product (DAP) was documented separately for left (LCA) and right coronary arteries (RCA) by summing up the single DAP for each angiographic projection...
February 7, 2018: European Radiology
https://www.readbyqxmd.com/read/29414171/life-cycle-techno-economic-and-dynamic-simulation-assessment-of-bioelectrochemical-systems-a-case-of-formic-acid-synthesis
#15
Mobolaji Shemfe, Siddharth Gadkari, Eileen Yu, Shahid Rasul, Keith Scott, Ian M Head, Sai Gu, Jhuma Sadhukhan
A novel framework, integrating dynamic simulation (DS), life cycle assessment (LCA) and techno-economic assessment (TEA) of a bioelectrochemical system (BES), has been developed to study for the first time wastewater treatment by removal of chemical oxygen demand (COD) by oxidation in anode and thereby harvesting electron and proton for carbon dioxide reduction reaction or reuse to produce products in cathode. Increases in initial COD and applied potential increase COD removal and production (in this case formic acid) rates...
January 31, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29412511/comprehensive-bile-acid-profiling-in-hereditary-intrahepatic-cholestasis-genetic-and-clinical-correlations
#16
Teng Liu, Ren-Xue Wang, Jun Han, Chen-Zhi Hao, Yi-Ling Qiu, Yan-Yan Yan, Li-Ting Li, Neng-Li Wang, Jing-Yu Gong, Yi Lu, Mei-Hong Zhang, Xin-Bao Xie, Jun-Cong Yang, Yi-Jie You, Jia-Qi Li, A S Knisely, Christoph H Borchers, Victor Ling, Jian-She Wang
BACKGROUND & AIMS: Genetic defects causing dysfunction in bile salt export pump (BSEP/ABCB11) lead to liver diseases. ABCB11 mutations alter the bile acid metabolome. We asked if profiling plasma bile acids could reveal compensatory mechanisms and track genetic and clinical status. METHODS: We compared plasma bile acids in 17 ABCB11-mutated patients, 35 healthy controls, and 12 genetically undiagnosed cholestatic patients by ultrahigh-performance liquid chromatography/multiple-reaction monitoring-mass spectrometry (UPLC/MRM-MS)...
February 7, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29408915/comorbidity-profiles-of-psoriasis-in-taiwan-a-latent-class-analysis
#17
Chen-Yi Wu, Hsiao-Yun Hu, Chung-Pin Li, Yiing-Jeng Chou, Yun-Ting Chang
BACKGROUND: Psoriasis is associated with many comorbidities. An understanding of these comorbidity patterns can help foster better care of patients with psoriasis. OBJECTIVE: To identify the heterogeneity of psoriasis comorbidities using latent class analysis (LCA). METHODS: LCA was used to empirically identify psoriasis comorbidity patterns in a nationwide sample of 110,729 incident cases of psoriasis (2002-2012) from the National Health Insurance database in Taiwan...
2018: PloS One
https://www.readbyqxmd.com/read/29407816/addressing-bystander-exposure-to-agricultural-pesticides-in-life-cycle-impact-assessment
#18
Morten Walbech Ryberg, Ralph K Rosenbaum, Luc Mosqueron, Peter Fantke
Residents living near agricultural fields may be exposed to pesticides drifting from the fields after application to different field crops. To address this currently missing exposure pathway in life cycle assessment (LCA), we developed a modeling framework for quantifying exposure of bystanders to pesticide spray drift from agricultural fields. Our framework consists of three parts addressing: (1) loss of pesticides from an agricultural field via spray drift; (2) environmental fate of pesticide in air outside of the treated field; and (3) exposure of bystanders to pesticides via inhalation...
February 1, 2018: Chemosphere
https://www.readbyqxmd.com/read/29407538/measurement-of-depression-treatment-among-patients-receiving-hiv-primary-care-whither-the-truth
#19
Bethany L DiPrete, Brian W Pence, David J Grelotti, Bradley N Gaynes
BACKGROUND: Prescription records, manual chart review, and patient self-report are each imperfect measures of depression treatment in HIV-infected adults. METHODS: We compared antidepressant prescription records in an electronic data warehouse with antidepressant treatment and psychotherapy identified via manual chart review and self-report for patients at 6 academic HIV treatment centers. We examined concordance among these three sources, and used latent class analysis (LCA) to estimate sensitivity and specificity of each measure...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29406730/quantified-uncertainties-in-comparative-life-cycle-assessment-what-can-be-concluded
#20
Angelica Mendoza Beltran, Valentina Prado, David Font Vivanco, Patrik J G Henriksson, Jeroen B Guinée, Reinout Heijungs
Interpretation of comparative Life Cycle Assessment (LCA) results can be challenging in the presence of uncertainty. To aid in interpreting such results under the goal of any comparative LCA, we aim to provide guidance to practitioners by gaining insights into uncertainty-statistics methods (USMs). We review five USMs-discernibility analysis, impact category relevance, overlap area of probability distributions, null hypothesis significance testing (NHST), and modified NHST-and provide a common notation, terminology, and calculation platform...
February 6, 2018: Environmental Science & Technology
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