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Refractory hypertension

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https://www.readbyqxmd.com/read/29456229/page-kidney-a-rare-but-surgically-treatable-cause-of-hypertension
#1
Ashok Kumar Sokhal, Gaurav Prakash, Durgesh Kumar Saini, Kawaljit Singh, Satyanarayan Sankhwar, Bhupendra Pal Singh
The Page kidney is a rare phenomenon. External renal parenchymal compression is the culprit. We report two cases of young males with flank pain, renal mass, and hypertension with history of blunt abdominal trauma. Initially, hypertension was controlled by angiotensin-converting enzyme (ACE) inhibitors but gradually became refractory to medical treatment. Laparoscopic nephrectomy was performed in both patients. We emphasize the Page kidney as a cause of hypertension in young patients, presenting with flank pain and renal mass with or without complications of hypertension...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29446053/systems-pharmacological-analysis-of-mitochondrial-cardiotoxicity-induced-by-selected-tyrosine-kinase-inhibitors
#2
Tanaya Vaidya, Jeff Kamta, Maher Chaar, Anusha Ande, Sihem Ait-Oudhia
Tyrosine kinase inhibitors (TKIs) are targeted therapies rapidly becoming favored over conventional cytotoxic chemotherapeutics. Our study investigates two FDA approved TKIs, DASATINIB; indicated for IMATINIB-refractory chronic myeloid leukemia, and SORAFENIB; indicated for hepatocellular carcinoma and advanced renal cell carcinoma. Limited but crucial evidence suggests that these agents can have cardiotoxic side effects ranging from hypertension to heart failure. A greater understanding of the underlying mechanisms of this cardiotoxicity are needed as concerns grow and the capacity to anticipate them is lacking...
February 14, 2018: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/29444665/comparison-of-1-year-outcomes-after-ahmed-glaucoma-valve-implantation-with-and-without-ologen-adjuvant
#3
Tai Jun Kim, Sohyun Kang, Jin Wook Jeoung, Young Kook Kim, Ki Ho Park
BACKGROUND: Many studies have investigated the clinical benefits of Ologen for trabeculectomy. However, its benefits for Ahmed glaucoma valve (AGV) implantation have not been investigated as extensively. The aim of this study was to compare the 1-year outcomes of AGV implantation with and without Ologen adjuvant for the treatment of refractory glaucoma. METHODS: This retrospective study included a total of 20 eyes of 20 glaucoma patients, who were followed for at least 1-year after undergoing AGV implantation...
February 14, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29436125/refractory-hypertension-focus-on-nighttime-blood-pressure-and-nondipping
#4
Cesare Cuspidi, Marijana Tadic, Guido Grassi
No abstract text is available yet for this article.
February 13, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29433169/in-reply-to-cisternostomy-surgical-alternative-for-patients-with-refractory-posttraumatic-intracranial-hypertension
#5
Lorenzo Giammattei, Mahmoud Messerer, Roy T Daniel
No abstract text is available yet for this article.
February 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29433168/cisternostomy-surgical-alternative-for-patients-with-refractory-posttraumatic-intracranial-hypertension
#6
Luis Rafael Moscote-Salazar, Alexis R Narvaez-Rojas, Alfonso Pacheco-Hernandez
No abstract text is available yet for this article.
February 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29420144/complications-of-optic-nerve-sheath-fenestration-as-a-treatment-for-idiopathic-intracranial-hypertension
#7
Aubrey L Gilbert, Bart Chwalisz, Robert Mallery
There are a number of surgical options for treatment of idiopathic intracranial hypertension (IIH) when it is refractory to medical treatment and weight loss. Optic nerve sheath fenestration (ONSF) is one of these options. Use of this procedure varies among centers due to experience with the procedure and concern for associated complications that can result in severe loss of vision. This review summarizes the literature concerning post-surgical complications of ONSF for IIH.
2018: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29397348/-resistant-hypertension-an-update
#8
N F Renna
An estimated 10% to 20% of hypertensive patients could be considered resistant to treatment (RH). These are patients who are not controlled using three drugs, at the maximum tolerated doses, including a diuretic, as well as those with high blood pressure controlled using four or more drugs. The term is used to identify patients that might benefit from special diagnostic and/or therapeutic consideration. The term 'refractory hypertension' has recently been proposed as a novel phenotype of antihypertensive failure...
January 31, 2018: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/29395350/intravenous-bevacizumab-for-refractory-hereditary-hemorrhagic-telangiectasia-related-epistaxis-and-gastrointestinal-bleeding
#9
Vivek N Iyer, Dinesh R Apala, Bibek S Pannu, Aditya Kotecha, Waleed Brinjikji, Michael D Leise, Patrick S Kamath, Sanjay Misra, Kebede H Begna, Rodrigo Cartin-Ceba, Hilary M DuBrock, Michael J Krowka, Erin K O'Brien, Rajiv K Pruthi, Darrell R Schroeder, Karen L Swanson
OBJECTIVE: To present a multiyear clinical experience with intravenous bevacizumab for the management of severe gastrointestinal bleeding and/or epistaxis in patients with hereditary hemorrhagic telangiectasia (HHT). PATIENTS AND METHODS: All patients treated with intravenous bevacizumab for severe hereditary hemorrhagic telangiectasia-related bleeding from June 1, 2013, through January 31, 2017, were included in this report. Severity of epistaxis (determined using the Epistaxis Severity Score questionnaire); hemoglobin, iron, and ferritin levels; and quality of life data were collected serially in all patients...
January 9, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29394206/secondary-glaucoma-due-to-iridescent-crystalline-particles-masquerading-as-refractory-hypertensive-uveitis-in-an-eye-with-irradiated-iris-melanoma
#10
Rupinder Chahal, Abhijit Anand Mohite, Heinrich Heimann, Atul Bansal
PURPOSE: We report a previously unrecognised mechanism of secondary glaucoma due to iridescent crystalline particles released from an irradiated iris melanoma. It masqueraded as refractory hypertensive uveitis following uncomplicated phacoemulsification. METHODS: A 58-year-old gentleman had an iris melanoma that underwent successful regression following irradiation with proton beam radiotherapy (PBRT). Three years later an uncomplicated phacoemulsification with intraocular lens implant was performed and subsequently the patient presented with apparently "refractory hypertensive uveitis"...
February 1, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29393752/treatment-of-idiopathic-intracranial-hypertension-via-stereotactic-placement-of-biventriculoperitoneal-shunts
#11
Michael Karsy, Hussam Abou-Al-Shaar, Christian A Bowers, Richard H Schmidt
OBJECTIVE Idiopathic intracranial hypertension (IIH), or pseudotumor cerebri, is a complex and difficult-to-manage condition that can lead to permanent vision loss and refractory headaches if untreated. Traditional treatment options, such as unilateral ventriculoperitoneal (VP) or lumboperitoneal (LP) shunt placement, have high complication and failure rates and often require multiple revisions. The use of bilateral proximal catheters has been hypothesized as a method to improve shunt survival. The use of stereotactic technology has improved the accuracy of catheter placement and may improve treatment of IIH, with fewer complications and greater shunt patency time...
February 2, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29387983/factors-involved-in-early-lenvatinib-dose-reduction-a-retrospective-analysis
#12
Koichi Suyama, Mai Tomiguchi, Takashi Takeshita, Aiko Sueta, Mutsuko Yamamoto-Ibusuki, Mototsugu Shimokawa, Yutaka Yamamoto, Hirotaka Iwase
Lenvatinib, a multi-tyrosine kinase inhibitor, has been proven to be an effective treatment option for patients with iodine-131-refractory thyroid cancer. Many adverse effects of lenvatinib have been reported; thus, dose reduction is common. However, a few studies have analyzed the causes of lenvatinib dose reduction in daily clinical practice. Here, we investigate the factors involved in early lenvatinib dose reduction to analyze lenvatinib dose modification. We analyzed 20 thyroid cancer patients who began receiving lenvatinib at the Kumamoto University Hospital Cancer Center from July 2015 to November 2016...
January 31, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29370977/severe-dysautonomia-as-a-main-feature-of-anti-gad-encephalitis-report-of-a-paediatric-case-and-literature-review
#13
Nedia Ben Achour, Thouraya Ben Younes, Ibtihel Rebai, Melika Ben Ahmed, Ichraf Kraoua, Ilhem Ben Youssef-Turki
INTRODUCTION: Anti-glutamic acid decarboxylase (anti-GAD65) antibodies are a rare cause of autoimmune encephalitis. This entity is mainly recognized in adults and very few cases were reported in children. We report on a paediatric case of anti-GAD encephalitis with severe presentation and uncontrollable dysautonomia. CASE STUDY: A 9-year-old girl was referred to our department for refractory seizures and behavioral disturbances. Brain magnetic resonance imaging (MRI) was normal...
January 12, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29360938/long-term-persistent-organic-pollutants-exposure-induced-telomere-dysfunction-and-senescence-associated-secretary-phenotype
#14
Jinghua Yuan, Yang Liu, Juan Wang, Yuxia Zhao, Keqiu Li, Yaqing Jing, Xiaoning Zhang, Qiang Liu, Xin Geng, Guang Li, Feng Wang
Environmentally persistent organic pollutant (POPs) is the general term for refractory organic compounds that show long-range atmospheric transport, environmental persistence, and bioaccumulation. It has been reported that the accumulation of POPs could lead to cellular DNA damage and adverse effects of on metabolic health. To better understand the mechanism of the health risks associated with POPs, we conducted an evidence based cohort investigation (n=5955) at the Jinghai e-waste disposal center in China from 2009-2016, where people endure serious POPs exposure...
January 19, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29356589/polytetrafluoroethylene-covered-stent-graft-versus-bare-stent-in-transjugular-intrahepatic-portosystemic-shunt-systematic-review-and-meta-analysis
#15
Tania Triantafyllou, Piyush Aggarwal, Ekansh Gupta, Wendy Jo Svetanoff, Deepak Prakash Bhirud, Saurabh Singhal
BACKGROUND & AIMS: Transjugular Intrahepatic Portosystemic Shunt (TIPS) is used to control refractory variceal bleeding secondary to portal hypertension. This meta-analysis was conducted to systematically review polytetrafluoroethylene-covered stent grafts (CS) versus bare stents (BS) in TIPS procedure. METHODS: Systematic search of literature databases was done from January-1990 till April-2017, using predecided keywords. Outcome measures studied were (1) primary-patency (PP) at 1 year (defined as absence of shunt insufficiency at 1 year), (2) rebleeding (RE) (3) new-onset hepatic encephalopathy ([HE] new-onset or worsening encephalopathy following the procedure), and (4) survival at 1 year (SU)...
January 22, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29353164/a-phase-ii-study-of-nab-paclitaxel-in-combination-with-ramucirumab-in-patients-with-previously-treated-advanced-gastric-cancer
#16
Hideaki Bando, Hideki Shimodaira, Kazumasa Fujitani, Atsuo Takashima, Kensei Yamaguchi, Norisuke Nakayama, Takehiro Takahashi, Eiji Oki, Mizutomo Azuma, Tomohiro Nishina, Shuichi Hironaka, Yoshito Komatsu, Kohei Shitara
BACKGROUND: Nanoparticle albumin-bound (nab)-paclitaxel was developed to improve paclitaxel solubility and does not need premedication to avoid infusion-related reactions associated with solvent-based (sb)-paclitaxel. We conducted a phase II trial to investigate the efficacy and safety of nab-paclitaxel plus ramucirumab combination therapy for previously treated advanced gastric cancer. PATIENTS AND METHODS: Patients with unresectable advanced gastric cancer refractory to first-line chemotherapy were administered nab-paclitaxel 100 mg/m2 intravenously on days 1, 8 and 15, plus ramucirumab 8 mg/kg intravenously on days 1 and 15 of a 28-day cycle...
January 17, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29349419/covered-endovascular-repair-of-the-paravisceral-aorta
#17
Markus Plimon, Jürgen Falkensammer, Fadi Taher, Afshin Assadian
Open aortic repair is considered the "gold standard" treatment for aortic occlusive disease. We present the case of an 83-year-old patient with refractory hypertension caused by paravisceral aortic stenosis including both renal arteries and the superior mesenteric artery. We planned an endovascular approach and treated the patient with parallel stent grafts in the paravisceral aorta. At 1.5 years after the operation, the patient was free of hypertensive episodes. Covered endovascular repair of the paravisceral aorta may be a valuable alternative to open aortic repair in patients unfit for open surgery...
September 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29349411/takayasu-arteritis-with-middle-aortic-syndrome-and-mesenteric-ischemia-treated-by-aortic-stenting
#18
Sarah Morrissey, Kong Teng Tan, John Stephen Byrne
A 48-year-old woman suffering from Takayasu arteritis presented with middle aortic syndrome consisting of abdominal pain, refractory hypertension with pulmonary edema and pleural effusions, and lower limb ischemia. She failed to improve with high-dose steroid therapy and underwent endovascular stenting of two severe stenoses in the supraceliac and infrarenal aorta. Her symptoms resolved and hypertension improved after the procedure.
September 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29341834/improvement-in-overall-survival-with-carfilzomib-lenalidomide-and-dexamethasone-in-patients-with-relapsed-or-refractory-multiple-myeloma
#19
David S Siegel, Meletios A Dimopoulos, Heinz Ludwig, Thierry Facon, Hartmut Goldschmidt, Andrzej Jakubowiak, Jesus San-Miguel, Mihaela Obreja, Julie Blaedel, A Keith Stewart
Purpose In the ASPIRE study of carfilzomib, lenalidomide, and dexamethasone (KRd) versus lenalidomide plus dexamethasone (Rd) in patients with relapsed or refractory multiple myeloma, progression-free survival was significantly improved in the carfilzomib group (hazard ratio, 0.69; two-sided P < .001). This prespecified analysis reports final overall survival (OS) data and updated safety results. Patients and Methods Adults with relapsed multiple myeloma (one to three prior lines of therapy) were eligible and randomly assigned at a one-to-one ratio to receive KRd or Rd in 28-day cycles until withdrawal of consent, disease progression, or occurrence of unacceptable toxicity...
January 17, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29339676/electrical-and-histological-remodeling-of-the-pulmonary-vein-in-2k1c-hypertensive-rats-indication-of-initiation-and-maintenance-of-atrial-fibrillation
#20
Pan Pan Xia, Lian Jing Li, Run Di Qi, Jiao Jiao Shi, Wei Zhu Ju, Ming Long Chen
OBJECTIVE: Hypertension is a significant risk factor for atrial fibrillation (AF). The role of pulmonary vein (PV) remodeling in the mechanistic association between hypertension and AF is not definitive. In this study, we aimed to identify changes in the electrophysiology and histology in PVs in two-kidney, one-clip (2K1C) hypertensive rats. METHODS: Fifty male Sprague-Dawley rats were classified into the 2K1C and sham-operated groups. The systolic blood pressure was measured every 2 weeks...
January 17, 2018: Anatolian Journal of Cardiology
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