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Breast cancer reconstruction

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https://www.readbyqxmd.com/read/28634720/the-financial-impact-and-drivers-of-hospital-charges-in-contralateral-prophylactic-mastectomy-and-reconstruction-a-nationwide-inpatient-sample-hospital-analysis
#1
Alexandra Bucknor, Anmol Chattha, Klaas Ultee, Winona Wu, Parisa Kamali, Patrick Bletsis, Austin Chen, Bernard T Lee, Claire Cronin, Samuel J Lin
PURPOSE: Rates of contralateral prophylactic mastectomy (CPM) have increased over the last decade; it is important for surgeons and hospital systems to understand the economic drivers of increased costs in these patients. This study aims to identify factors affecting charges in those undergoing CPM and reconstruction. METHODS: Analysis of the Healthcare Cost and Utilization Project National Inpatient Sample was undertaken (2009-2012), identifying women aged ≥18 with unilateral breast cancer undergoing unilateral mastectomy with CPM and immediate breast reconstruction (IBR) (CPM group), in addition to unilateral mastectomy and IBR alone (UM group)...
June 20, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28626876/optical-molecular-imaging-guided-radiation-therapy-part-2-integrated-x-ray-and-fluorescence-molecular-tomography
#2
Junwei Shi, Thirupandiyur S Udayakumar, Zhiqun Wang, Nesrin Dogan, Alan Pollack, Yidong Yang
PURPOSE: Differentiating tumor from its surrounding soft tissues is challenging for x-ray computed tomography (CT). Fluorescence molecular tomography (FMT) can directly localize the internal tumors targeted with specific fluorescent probes. A FMT system was developed and integrated onto a CT guided irradiator to improve tumor localization for image guided radiation. METHODS: The FMT system was aligned orthogonal to the cone beam CT onboard our previously developed image guided small animal arc radiation treatment system (iSMAART)...
June 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28624714/patient-reported-outcomes-of-autologous-fat-grafting-after-breast-cancer-surgery
#3
A W W Brown, M Kabir, K A Sherman, F Meybodi, J R French, E B Elder
INTRODUCTION: Autologous fat grafting (AFG) can be used as an adjunct in breast cancer surgery to improve contour defects. Few previous studies have assessed patient reported outcomes (PROs) for AFG. This study analysed AFG use and assessed PROs in terms of physical and psychosocial well-being. MATERIALS AND METHODS: All patients undergoing AFG were identified from a prospective database and asked to complete the validated BREAST-Q questionnaire and a tool to assess patient-perceived change after AFG (5-point Likert-type scale)...
June 15, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28624048/comparison-of-two-different-types-of-oxidized-regenerated-cellulose-for-partial-breast-defects
#4
Jeeyeon Lee, Jin Hyang Jung, Wan Wook Kim, Jung Dug Yang, Jeong Woo Lee, Junjie Li, Ho Yong Park
BACKGROUND: A defect after partial mastectomy, sometimes, is hard to be filled with patient's own breast tissue. Two different types of oxidized regenerated cellulose (ORC) for filling of partial defects in small-sized breasts were compared with respect to clinicopathologic factors and outcomes. METHODS: A total of 45 patients with breast cancer underwent conventional partial mastectomy with insertion of an ORC filling material. The two filling materials used were a hemostasis-purposed ORC and adhesion barrier-purposed ORC...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28616687/controversies-in-the-role-of-postmastectomy-radiotherapy-in-breast-cancer-patients-with-one-to-three-positive-axillary-nodes-and-safety-of-integrating-radiotherapy-and-breast-reconstruction
#5
EDITORIAL
Kenji Sekiguchi
No abstract text is available yet for this article.
June 14, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28615812/optimising-aesthetic-outcome-after-nipple-areola-complex-sparing-mastectomy-and-immediate-one-stage-prosthetic-reconstruction-a-simple-surgical-trick-to-fix-nipple-areola-complex-position
#6
Luca Maione, Andrea Lisa, Federico Barbera, Mattia Siliprandi, Valeriano Vinci, Francesco Klinger, Marco Klinger
BACKGROUND: Nipple-areola complex (NAC) sparing mastectomy (NSM) is mostly indicated in patients with small-/medium-sized and non-ptotic breasts, while skin-reducing mastectomy is used in patients with medium or large breasts with severe ptosis. NAC location on the reconstructed breast is one of the major factors in determining the final aesthetic result and patients' satisfaction. An optimum result obtained at the end of surgical procedure may be altered and compromised by skin redistribution and consequently NAC depositioning during the post-operative period in patients with medium-sized breasts and a moderate degree of ptosis...
January 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28615810/computed-tomography-angiographic-study-of-internal-mammary-perforators-and-their-use-as-recipient-vessels-for-free-tissue-transfer-in-breast-reconstruction
#7
Aditya V Kanoi, Karnav B Panchal, Saugata Sen, Gautam Biswas
CONTEXT: The internal mammary artery perforator vessels (IMPV) as a recipient in free flap breast reconstruction offer advantages over the more commonly used thoracodorsal vessels and the internal mammary vessels (IMV). AIMS: This study was designed to assess the anatomical consistency of the IMPV and the suitability of these vessels for use as recipients in free flap breast reconstruction. PATIENTS AND METHODS: Data from ten randomly selected female patients who did not have any chest wall or breast pathology but had undergone a computed tomography angiography (CTA) for unrelated diagnostic reasons from April 2013 to October 2013 were analysed...
January 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28615672/reconstruction-of-pathway-modification-induced-by-nicotinamide-using-multi-omic-network-analyses-in-triple-negative-breast-cancer
#8
Ji Young Kim, Hyebin Lee, Jongmin Woo, Wang Yue, Kwangsoo Kim, Seongmin Choi, Ja-June Jang, Youngsoo Kim, In Ae Park, Dohyun Han, Han Suk Ryu
Triple negative breast cancer (TNBC) is characterized by an aggressive biological behavior in the absence of a specific target agent. Nicotinamide has recently been proven to be a novel therapeutic agent for skin tumors in an ONTRAC trial. We performed combinatory transcriptomic and in-depth proteomic analyses to characterize the network of molecular interactions in TNBC cells treated with nicotinamide. The multi-omic profiles revealed that nicotinamide drives significant functional alterations related to major cellular pathways, including the cell cycle, DNA replication, apoptosis and DNA damage repair...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28612125/impact-of-bilateral-prophylactic-mastectomy-and-immediate-reconstruction-on-health-related-quality-of-life-in-women-at-high-risk-for-breast-carcinoma-results-of-the-mastectomy-reconstruction-outcomes-consortium-study
#9
Colleen M McCarthy, Jennifer B Hamill, Hyungjin Myra Kim, Ji Qi, Edwin Wilkins, Andrea L Pusic
BACKGROUND: Although bilateral prophylactic mastectomy (BPM) can reduce the risk of breast cancer, the decision to proceed surgically can have significant consequences and requires careful deliberation. To facilitate decision making for women at high risk for breast carcinoma, the risks and benefits of BPM should be well-elucidated. We sought to determine the effects of BPM and immediate reconstruction on health-related quality-of-life outcomes among a multisite cohort of women at high risk for breast carcinoma...
June 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28610896/breast-conserving-therapy-for-breast-cancer-cosmetic-results-and-options-for-delayed-reconstruction
#10
Vera L Negenborn, José H Volders, Nicole M A Krekel, Max H Haloua, Mark-Bram Bouman, Marlon E Buncamper, Frank B Niessen, Hay A H Winters, Caroline B Terwee, Sybren Meijer, M Petrousjka van den Tol
OBJECTIVES: Optimisation of the cosmetic outcome after breast-conserving therapy (BCT) is important. We aimed to determine the cosmetic outcome following BCT and factors influencing this cosmesis and identify the most favourable options for delayed breast reconstruction. MATERIALS AND METHODS: Four reconstructive surgeons evaluated the cosmetic outcome of 109 patients after BCT. Additionally, the surgeons indicated which patients were amenable for delayed reconstruction and the preferred type of reconstruction...
May 18, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28608612/factors-impacting-the-accuracy-of-intra-operative-evaluation-of-sentinel-lymph-nodes-in-breast-cancer
#11
Catherine L Akay, Constance Albarracin, Tiffany Torstenson, Roland Bassett, Elizabeth A Mittendorf, Min Yi, Henry M Kuerer, Gildy V Babiera, Isabelle Bedrosian, Kelly K Hunt, Rosa F Hwang
Sentinel lymph node dissection (SLND) is a standard axillary staging technique in breast cancer and intraoperative sentinel lymph node (SLN) assessment is important for decision-making regarding additional treatment and reconstruction. This study was undertaken to investigate clinicopathologic factors impacting the accuracy of intraoperative SLN evaluation. Records of patients with clinically node-negative, invasive breast cancer who underwent SLND with frozen section intraoperative pathologic evaluation from 2004 to 2007 were reviewed...
June 13, 2017: Breast Journal
https://www.readbyqxmd.com/read/28608119/breast-specific-sensuality-and-sexual-function-in-cancer-survivorship-does-surgical-modality-matter
#12
Jennifer S Gass, Michaela Onstad, Sarah Pesek, Kristin Rojas, Sara Fogarty, Ashley Stuckey, Christina Raker, Don S Dizon
PURPOSE: More early-staged breast cancer patients are choosing mastectomy. No studies have addressed breast-specific sensuality (BSS), defined as the breast's role during intimacy. We explored BSS among women undergoing lumpectomy (L), mastectomy alone (M), or with reconstruction (MR) and analyzed the association of surgical modality with sexual function. METHODS: Women undergoing breast cancer surgery between 2000 and 2013 were eligible for survey using investigator-generated questions and the Female Sexual Function Index (FSFI)...
June 12, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28602267/post-reconstruction-dermatitis-of-the-breast
#13
A C Rosen, C Goh, M E Lacouture, B J Mehrara, P G Cordeiro, P L Myskowski
BACKGROUND: Approximately one-third of women diagnosed with breast cancer undergo mastectomy with subsequent implant-based or autogenous tissue-based reconstruction. Potential complications include infection, capsular contracture, and leak or rupture of implants with necessity for explantation. Skin rashes are infrequently described complications of patients who undergo mastectomy with or without reconstruction. METHODS: A retrospective analysis of breast cancer patients referred to the Dermatology Service for diagnosis and management of a rash post-mastectomy and expander or implant placement or transverse rectus abdominis myocutaneous (TRAM) flap reconstruction was performed...
May 20, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28600242/advanced-fast-3d-electromagnetic-solver-for-microwave-tomography-imaging
#14
Nikolai Simonov, Bo-Ra Kim, Kwang-Jae Lee, Soon-Ik Jeon, Seong-Ho Son
This paper describes a fast forward electromagnetic solver (FFS) for the image reconstruction algorithm of our microwave tomography (MT) system. Our apparatus is a preclinical prototype of a biomedical imaging system, designed for the purpose of early breast cancer detection. It operates in the 3-6 GHz frequency band using a circular array of probe antennas immersed in a matching liquid; it produces image reconstructions of the permittivity and conductivity profiles of the breast under examination. Our reconstruction algorithm solves the electromagnetic inverse problem and takes into account the real electromagnetic properties of the probe antenna array as well as the influence of the patient's body and that of the upper metal screen sheet...
June 7, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28596419/intra-tumor-heterogeneity-novel-approaches-for-resolving-genomic-architecture-and-clonal-evolution
#15
Ravi G Gupta, Robert A Somer
High-throughput genomic technologies have revealed a remarkably complex portrait of intra-tumor heterogeneity in cancer and have shown that tumors evolve through a reiterative process of genetic diversification and clonal selection. This discovery has challenged the classical paradigm of clonal dominance and brought attention to subclonal tumor cell populations that contribute to the cancer phenotype. Dynamic evolutionary models may explain how these populations grow within the ecosystem of tissues, including linear, branching, neutral and punctuated patterns...
June 8, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28594922/the-learning-curve-of-endoscopic-total-mastectomy-in-taiwan-a-multi-center-study
#16
Chin-Sheng Hung, Sheng-Wei Chang, Li-Min Liao, Cheng-Chiao Huang, Shih-Hsin Tu, Shou-Tung Chen, Dar-Ren Chen, Shou-Jen Kuo, Hung-Wen Lai, Ting-Mao Chou, Yao-Lung Kuo
INTRODUCTION: Laparoscopic techniques are commonly used in abdominal and gynecologic surgery, while breast cancer surgery has remained largely unchanged. In Asia, especially in Japan, many surgeons have started to use endoscopic surgery for breast cancer. In Taiwan, endoscopy-assisted breast surgery started in 2010. The benefits of this surgical method include smaller incisions, an axillary anatomic approach, clear vision, no oncologic compromise, and good cosmetic outcomes. This is the first report to discuss the learning curve of endoscopy-assisted breast surgery, including the difficulties experienced...
2017: PloS One
https://www.readbyqxmd.com/read/28594745/indications-for-contralateral-prophylactic-mastectomy-a-consensus-statement-using-modified-delphi-methodology
#17
Frances C Wright, Nicole J Look Hong, May Lynn Quan, Kaitlyn Beyfuss, Sara Temple, Andrea Covelli, Nancy Baxter, Anna R Gagliardi
OBJECTIVE: To reach a consensus about contralateral prophylactic mastectomy in unilateral breast cancer. SUMMARY BACKGROUND DATA: There has been a substantial increase in the number of North American women with unilateral breast cancer undergoing a therapeutic mastectomy and a contralateral prophylactic mastectomy (CPM) either simultaneously or sequentially. The purpose of this project was to create a nationally endorsed consensus statement for CPM in women with unilateral breast cancer using modified Delphi consensus methodology...
June 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28594742/outcomes-of-lymphedema-microsurgery-for-breast-cancer-related-lymphedema-with-or-without-microvascular-breast-reconstruction
#18
Holger Engel, Chia-Yu Lin, Jung-Ju Huang, Ming-Huei Cheng
OBJECTIVE: This study investigated the outcome of lymphedema microsurgery with or without microsurgical breast reconstruction for breast cancer-related lymphedema (BCRL). BACKGROUND: Complete decongestive therapy, lymphovenous anastomosis, and vascularized lymph node flap transfer are the 3 major treatment modalities for BCRL. Releasing axillary contracture and transferring a free flap may potentially improve the BCRL. METHODS: Between 2004 and 2015, 124 patients with BCRL who underwent 3 treatment modalities without or with microsurgical breast reconstruction were included in this study as groups I and II, respectively...
June 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28593488/optimizing-patient-selection-for-direct-to-implant-immediate-breast-reconstruction-using-wise-pattern-skin-reducing-mastectomy-in-large-and-ptotic-breasts
#19
Amir Inbal, Eyal Gur, Benjamin T Lemelman, Daphna Barsuk, Tehilla Menes, David Leshem, Yoav Barnea
BACKGROUND: Immediate breast reconstruction in large and ptotic breasts is challenging, often requiring skin-reducing procedures. The Wise-pattern skin-reducing mastectomy (WPSRM) technique provides reliable one-stage implant coverage using the pectoralis muscle and a de-epithelialized inferiorly based dermal flap. However, de-vascularization may result in mastectomy skin flap necrosis. We aimed to critically evaluate and isolate patients at high risk of complications using this procedure...
June 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28589870/-making-better-use-of-the-clinical-geneticist-s-expertise-treating-physician-could-request-a-dna-test-for-most-cancer-patients
#20
C M Aalfs, A M Westermann, C G van El
Eight university medical centres in the Netherlands have established clinical genetic services. Patients receive intensive, and therefore costly, genetic counselling before genetic testing takes place. In recent years the number of patients referred to clinical genetic services has risen dramatically, creating waiting-list backlogs. Knowing your carrier status in hereditary cancers, for instance for a BRCA1/2 mutation, can have consequences for surveillance, treatment, and prevention; however, 90% of patients with breast cancer do not have a mutation...
2017: Nederlands Tijdschrift Voor Geneeskunde
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