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Breast cancer reconstruction

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https://www.readbyqxmd.com/read/29651851/patient-satisfaction-after-breast-reconstruction-implants-vs-autologous-tissues
#1
S Fracon, N Renzi, M Manara, V Ramella, G Papa, Z M Arnež
INTRODUCTION: Breast reconstruction is increasingly present in the treatment of breast cancer. It may be accomplished with implants or autologous tissues. This cross-sectional study evaluates patients satisfaction and quality of life in women after successful autologous or implant breast reconstruction. MATERIAL AND METHODS: 109 women who successfully underwent breast reconstruction between 2007 and 2016 were included. The patients completed the BREAST-Q questionnaire at follow-up visits...
2018: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/29623676/cost-effectiveness-of-the-breconda-decision-aid-for-women-with-breast-cancer-results-from-a-randomized-controlled-trial
#2
Bonny Parkinson, Kerry A Sherman, Paul Brown, Laura-Kate E Shaw, John Boyages, Linda D Cameron, Elisabeth Elder, Thomas Lam
OBJECTIVE: To report on the cost-effectiveness of BRECONDA (Breast RECONstruction Decision Aid), a web-based decision aid to facilitate decisions regarding breast reconstruction surgery, with usual care for women with breast cancer. METHODS: The economic evaluation was conducted alongside a randomized controlled trial. Women diagnosed with breast cancer or ductal carcinoma in situ and eligible for breast reconstruction following mastectomy were randomized to access BRECONDA for 6 months + usual care (n = 106) or usual care (n = 116) and were assessed at baseline preintervention, and then 1-month and 6-months post-randomization...
April 5, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29623151/nipple-areolar-complex-reconstruction-a-review-of-the-literature-and-introduction-of-the-rectangle-to-cube-nipple-flap
#3
Joshua T Henderson, Thomas J Lee, Andrew M Swiergosz, Andrea R Hiller, Joshua Choo, Bradon J Wilhelmi
Objective : There are many approaches to nipple-areola complex reconstruction. Tissue quality and thickness, desired nipple location and size, scar position, and surgeon preference all play a role in selecting a technique. We present the rectangle-to-cube nipple flap, a new technique for challenging nipple reconstruction. A review of published techniques is compared and contrasted with this flap design. Methods : Following bilateral total skin-sparing mastectomies, a patient with breast cancer underwent breast reconstruction with tissue expanders and subsequent nipple reconstruction with the rectangle-to-cube nipple flap...
2018: Eplasty
https://www.readbyqxmd.com/read/29620792/risk-reducing-mastectomy-for-the-prevention-of-primary-breast-cancer
#4
REVIEW
Nora E Carbine, Liz Lostumbo, Judi Wallace, Henry Ko
BACKGROUND: Recent progress in understanding the genetic basis of breast cancer and widely publicized reports of celebrities undergoing risk-reducing mastectomy (RRM) have increased interest in RRM as a method of preventing breast cancer. This is an update of a Cochrane Review first published in 2004 and previously updated in 2006 and 2010. OBJECTIVES: (i) To determine whether risk-reducing mastectomy reduces death rates from any cause in women who have never had breast cancer and in women who have a history of breast cancer in one breast, and (ii) to examine the effect of risk-reducing mastectomy on other endpoints, including breast cancer incidence, breast cancer mortality, disease-free survival, physical morbidity, and psychosocial outcomes...
April 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29620551/practical-applications-of-delayed-immediate-autologous-breast-reconstruction-a-flexible-and-safe-operative-strategy
#5
Gloria R Sue, Arhana Chattopadhyay, Chao Long, Eva Huis 't Veld, Gordon K Lee
BACKGROUND: Timing is an important consideration in patients undergoing mastectomy for breast cancer. While immediate reconstruction results in superior aesthetic outcomes, the need for postmastectomy radiation can often only be ascertained after review of surgical pathology. Delayed-immediate autologous reconstruction (DIAR) is a reconstructive approach that consists of mastectomy with tissue expander placement in the first stage and flap-based breast reconstruction in the second stage...
April 3, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29619346/factors-influencing-the-rate-of-post-mastectomy-breast-reconstruction-in-a-canadian-teaching-hospital
#6
Mihiran Karunanayake, Patricia Bortoluzzi, André Chollet, Jenny C Lin
Background: Post-mastectomy breast reconstruction (PMBR) improves psychosocial well-being, quality of life, and body image. Reconstruction rates vary widely (up to 42% in the United States), but the few Canadian studies available report rates of 3.8% to 7.9%. We sought to evaluate the current state of breast reconstruction in 1 Canadian teaching hospital and factors determining patients' access to reconstruction. Methods: We performed a retrospective chart review of all patients with breast cancer undergoing mastectomy alone or mastectomy and reconstruction at a Canadian hospital between 2010 and 2013...
November 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29616659/introduction-of-a-hybrid-treatment-delivery-system-used-for-quality-assurance-in-multi-catheter-interstitial-brachytherapy
#7
Karoline Kallis, Stephan Kreppner, Michael Lotter, Vratislav Strnad, Rainer Fietkau, Christoph Bert
Multi-catheter interstitial brachytherapy (iBT) is a treatment option for breast cancer patients after breast conserving surgery. Typically, only a few additional quality interventions after the first irradiation have been introduced to ensure the planned treatment delivery. Therefore, the purpose of this study is to show the possibilities of an electromagnetic tracking (EMT) system integrated into the afterloader for quality assurance (QA) in high-dose rate (HDR) iBT of patients with breast cancer. 
 The hybrid afterloader system equipped with an electromagnetic sensor was used for all phantom and patient measurements...
April 4, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29611029/randomized-trial-of-proactive-rapid-genetic-counseling-versus-usual-care-for-newly-diagnosed-breast-cancer-patients
#8
Marc D Schwartz, Beth N Peshkin, Claudine Isaacs, Shawna Willey, Heiddis B Valdimarsdottir, Rachel Nusbaum, Gillian Hooker, Suzanne O'Neill, Lina Jandorf, Scott P Kelly, Jessica Heinzmann, Aliza Zidell, Katia Khoury
PURPOSE: Breast cancer patients who carry BRCA1/BRCA2 gene mutations may consider bilateral mastectomy. Having bilateral mastectomy at the time of diagnosis not only reduces risk of a contralateral breast cancer, but can eliminate the need for radiation therapy and yield improved reconstruction options. However, most patients do not receive genetic counseling or testing at the time of their diagnosis. In this trial, we tested proactive rapid genetic counseling and testing (RGCT) in newly diagnosed breast cancer patients in order to facilitate pre-surgical genetic counseling and testing...
April 2, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29608972/alternative-methodological-approach-to-randomized-trial-for-surgical-procedures-routinely-used
#9
T Filleron, A Lusque, F Dalenc, G Ferron, H Roche, A Martinez, E Jouve
BACKGROUND: In medical oncology, changes in practices are almost always based on randomized trials but medical history shows that it is different in surgical oncology. In the past, many surgical procedures were routinely performed without a rigorous evaluation of the risk-benefit. To highlight the complexity of developing randomized surgical trials, disquisitions on methodology presented in the medical literature. This is particularly true when we consider breast reconstruction after surgical treatment for breast cancer...
March 30, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29605247/breast-reconstruction-after-breast-conservation-therapy-for-breast-cancer
#10
Filip E F Thiessen, Wiebren A A Tjalma, Thierry Tondu
Conservative breast surgery followed by irradiation, often referred to as Breast conserving therapy (BCT), has replaced modified radical mastectomy for the treatment of early stage invasive breast cancer and ductal carcinoma in situ (DCIS). About 10% to 40% of the patients treated with BCT have poor cosmetic outcome results. Small tumours in large breasts can be successfully treated by lumpectomy and radiotherapy, with good cosmetic outcome. However when the tumour breast ratio is higher, the cosmetic outcome can be very disappointing...
March 27, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29600521/phytosomal-curcumin-antagonizes-cell-growth-and-migration-induced-by-thrombin-through-amp-kinase-in-breast-cancer
#11
Milad Hashemzehi, Reihane Behnam-Rassouli, Seyed Mahdi Hassanian, Maryam Moradi-Binabaj, Reyhaneh Moradi-Marjaneh, Farzad Rahmani, Hamid Fiuji, Mahdi Jamili, Mahdi Mirahmadi, Nadia Boromand, Mehran Piran, Mohieddin Jafari, Amirhossein Sahebkar, Amir Avan, Majid Khazaei
Here we explored the antitumor-activity of novel-formulated-form of curcumin (phytosomal-encapsulated-curcumin) or in combination with 5-FU in breast cancer. The antiproliferative activity was assessed in 2D and 3-dimensional cell-culture-model. The migratory-behaviors of the cells were determined by migration assay. The expression levels of CyclinD1,GSK3a/b, P-AMPK, MMP9, and E-cadherin were studied by qRT-PCR and/or Western blotting. The anti-inflammatory of nano-curcumin was assessed, while antioxidant activity was evaluated by malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and total thiols (T-SH)...
March 30, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29598924/oncentra-brachytherapy-planning-system
#12
REVIEW
Jack Yang
In modern cancer management, treatment planning has progressed as a contemporary tool with all the advances in computing power in recent years. One of the advanced planning tools uses 3-dimensional (3D) data sets for accurate dose distributions in patient prescription. Among these planning processes, brachytherapy has been a very important part of a successful cancer management program, offering clinical benefits with specific or combined treatments with external beam therapy. In this chapter, we mainly discussed the Elekta Oncentra planning system, which is the main treatment planning tool for high-dose rate (HDR) modality in our facility and in many other facilities in the United States...
March 27, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29596197/quilting-sutures-after-latissimus-dorsi-breast-reconstruction-in-breast-cancer-patients-might-lead-to-reduced-risk-of-developing-arm-lymphedema-by-reducing-seroma-risk
#13
https://www.readbyqxmd.com/read/29582584/dysregulation-of-metabolic-associated-pathways-in-muscle-of-breast-cancer-patients-preclinical-evaluation-of-interleukin-15-targeting-fatigue
#14
Joseph Bohlen, Sarah L McLaughlin, Hannah Hazard-Jenkins, Aniello M Infante, Cortney Montgomery, Mary Davis, Emidio E Pistilli
BACKGROUND: Breast cancer patients report a perception of increased muscle fatigue, which can persist following surgery and standardized therapies. In a clinical experiment, we tested the hypothesis that pathways regulating skeletal muscle fatigue are down-regulated in skeletal muscle of breast cancer patients and that different muscle gene expression patterns exist between breast tumour subtypes. In a preclinical study, we tested the hypothesis that mammary tumour growth in mice induces skeletal muscle fatigue and that overexpression of the cytokine interleukin-15 (IL-15) can attenuate mammary tumour-induced muscle fatigue...
March 26, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29582162/low-adherence-to-the-western-and-high-adherence-to-the-mediterranean-dietary-patterns-could-prevent-colorectal-cancer
#15
Adela Castelló, Pilar Amiano, Nerea Fernández de Larrea, Vicente Martín, Maria Henar Alonso, Gemma Castaño-Vinyals, Beatriz Pérez-Gómez, Rocío Olmedo-Requena, Marcela Guevara, Guillermo Fernandez-Tardon, Trinidad Dierssen-Sotos, Cristobal Llorens-Ivorra, Jose María Huerta, Rocío Capelo, Tania Fernández-Villa, Anna Díez-Villanueva, Carmen Urtiaga, Jesús Castilla, Jose Juan Jiménez-Moleón, Víctor Moreno, Verónica Dávila-Batista, Manolis Kogevinas, Nuria Aragonés, Marina Pollán
PURPOSE: To assess if the associations found between three previously identified dietary patterns with breast, prostate and gastric cancer are also observed for colorectal cancer (CRC). METHODS: MCC-Spain is a multicase-control study that collected information of 1629 incident cases of CRC and 3509 population-based controls from 11 Spanish provinces. Western, Prudent and Mediterranean data-driven dietary patterns-derived in another Spanish case-control study-were reconstructed in MCC-Spain...
March 26, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29582015/disparities-in-breast-cancer-tumor-characteristics-treatment-time-to-treatment-and-survival-probability-among-african-american-and-white-women
#16
Kevin Chu Foy, James L Fisher, Maryam B Lustberg, Darrell M Gray, Cecilia R DeGraffinreid, Electra D Paskett
African American (AA) women have a 42% higher breast cancer death rate compared to white women despite recent advancements in management of the disease. We examined racial differences in clinical and tumor characteristics, treatment and survival in patients diagnosed with breast cancer between 2005 and 2014 at a single institution, the James Cancer Hospital, and who were included in the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Cancer Registry in Columbus OH. Statistical analyses included likelihood ratio chi-square tests for differences in proportions, as well as univariate and multivariate Cox proportional hazards regressions to examine associations between race and overall and progression-free survival probabilities...
2018: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29577505/efficacy-and-safety-of-bilateral-thoracic-paravertebral-blocks-in-outpatient-breast-surgery
#17
Linden K Head, Anne Lui, Kirsty Usher Boyd
Unilateral thoracic paravertebral blocks (TPVBs) have demonstrated reliable intraoperative analgesia, low postoperative pain scores, and an opioid-sparing effect in breast cancer surgery. However, secondary to the perceived risk of complications, bilateral TPVB have been less well accepted and are less frequently used. The purpose of this study was to evaluate the feasibility of using bilateral TPVBs in outpatient surgery for patients undergoing bilateral mastectomy with immediate implant-based reconstruction...
March 25, 2018: Breast Journal
https://www.readbyqxmd.com/read/29572848/experimental-validation-of-absolute-spect-ct-quantification-for-response-monitoring-in-breast-cancer
#18
Angela Collarino, Lenka M Pereira Arias-Bouda, Renato A Valdés Olmos, Pieternel van der Tol, Petra Dibbets-Schneider, Lioe-Fee de Geus-Oei, Floris Hp van Velden
PURPOSE: Recent developments in iterative image reconstruction enable absolute quantification of SPECT/CT studies by incorporating compensation for collimator-detector response, attenuation and scatter as well as resolution recovery into the reconstruction process (Evolution; Q.Metrix package; GE Healthcare). The aim of this experimental study is to assess its quantitative accuracy for potential clinical 99m Tc-sestamibi (MIBI)-related SPECT/CT application in neoadjuvant chemotherapy response studies in breast cancer...
March 23, 2018: Medical Physics
https://www.readbyqxmd.com/read/29564032/postmastectomy-breast-reconstruction-with-the-totally-autologous-latissimus-dorsi-flap-in-the-thin-small-breasted-woman-give-it-more-thought
#19
Fawz Kazzazi, Rosanna C Ching, Charles M Malata
Introduction: Thin women have fewer autologous tissue breast reconstructive options than their higher body mass index counterparts-due to a lack of adequate donor sites. They are therefore usually offered expander/implant techniques. The total autologous latissimus dorsi flap is generally used in "well-padded" individuals, as they have enough fat on their back on which a completely autologous reconstruction could be based. When implant-based reconstruction is contraindicated (for instance due to planned adjuvant radiotherapy) or unacceptable to the patient, the total autologous latissimus dorsi flap can provide adequate tissue volume by utilizing the additional back fat deposits even in the thin, small-breasted patient...
2018: Eplasty
https://www.readbyqxmd.com/read/29560828/a-homologous-mapping-method-for-three-dimensional-reconstruction-of-protein-networks-reveals-disease-associated-mutations
#20
Sing-Han Huang, Yu-Shu Lo, Yong-Chun Luo, Yu-Yao Tseng, Jinn-Moon Yang
BACKGROUND: One of the crucial steps toward understanding the associations among molecular interactions, pathways, and diseases in a cell is to investigate detailed atomic protein-protein interactions (PPIs) in the structural interactome. Despite the availability of large-scale methods for analyzing PPI networks, these methods often focused on PPI networks using genome-scale data and/or known experimental PPIs. However, these methods are unable to provide structurally resolved interaction residues and their conservations in PPI networks...
March 19, 2018: BMC Systems Biology
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