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https://www.readbyqxmd.com/read/27933213/molecular-pathology-of-cancer-how-to-communicate-with-disease
#1
REVIEW
Peter Birner, Gerald Prager, Berthold Streubel
: Recent technical advances have brought insights into the biology of cancer in human, establishing it as a disease driven by genetic mutations. Beside inherited family tumour syndromes caused by germline mutations, somatic genetic alterations occur early in tumourigenesis, which accumulate during the progression of the disease and its treatment. Based on these observations, medical oncology has started to enter an era of stratified medicine, where treatment selection is becoming tailored to drugable molecular pathways...
2016: ESMO Open
https://www.readbyqxmd.com/read/27932895/are-patients-and-doctors-accounts-of-the-first-specialist-consultation-for-chronic-back-pain-in-agreement
#2
Kathy B White, John Lee, Amanda C de C Williams
INTRODUCTION: The first consultation at a specialist pain clinic is potentially a pivotal event in a patient's pain history, affecting treatment adherence and engagement with longer term self-management. What doctors communicate to patients about their chronic pain and how patients interpret doctors' messages and explanations in pain consultations are under-investigated, particularly in specialist care. Yet, patients value personalized information about their pain problem. PATIENTS AND METHODS: Sixteen patients in their first specialist pain clinic consultation and the doctors they consulted were interviewed shortly after the consultation...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27932630/hospital-doctors-understanding-of-use-and-withdrawal-of-the-liverpool-care-pathway-a-qualitative-study-of-practice-based-experiences-during-times-of-change
#3
Sharon Twigger, Sarah J Yardley
BACKGROUND: The Liverpool Care Pathway was used in UK hospitals (late 1990s to July 2014) in an attempt to generate hospice-style high-quality end-of-life care in acute settings. Despite being widely established, there was limited research or contextual evidence regarding this approach or its impact. Growing criticism from the public, media, politicians and healthcare professionals culminated with a critical independent review (July 2013) and subsequent withdrawal of the Liverpool Care Pathway...
December 8, 2016: Palliative Medicine
https://www.readbyqxmd.com/read/27932589/sex-and-race-ethnicity-differences-in-following-dietary-and-exercise-recommendations-for-u-s-representative-sample-of-adults-with-type-2-diabetes
#4
Joan A Vaccaro, Fatma G Huffman
This study examined sex by race/ethnicity differences in medical advice received for diet and exercise with corresponding health behaviors of a U.S. representative sample of adults with type 2 diabetes (N = 1,269). Data from the National Health and Nutrition Examination Surveys for 2011-2014 for 185 Mexican Americans, 123 Other Hispanics, 392 non-Hispanic Blacks, 140 non-Hispanic Asians, and 429 non-Hispanic Whites were analyzed using logistic regression analyses. Reporting being given dietary and exercise advice was positively associated with reporting following the behavior...
December 7, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27932369/patient-safety-in-community-dementia-services-what-can-we-learn-from-the-experiences-of-caregivers-and-healthcare-professionals
#5
Sophie Behrman, Philip Wilkinson, Helen Lloyd, Charles Vincent
OBJECTIVES: this study aims to explore how patient safety in community dementia services is understood by caregivers, and healthcare professionals. METHODS: cross-sectional analysis of guided one-to-one interviews with 10 caregivers, and 10 healthcare professionals. RESULTS: caregivers and healthcare professionals identified a range of issues including medication errors, mis-communication between professionals, unclear service pathways and the effects of stress on caregivers' behaviour...
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27932233/schizophrenia-risk-alleles-and-neurodevelopmental-outcomes-in-childhood-a-population-based-cohort-study
#6
Lucy Riglin, Stephan Collishaw, Alexander Richards, Ajay K Thapar, Barbara Maughan, Michael C O'Donovan, Anita Thapar
BACKGROUND: Schizophrenia typically onsets after puberty but is often preceded by observable childhood neurodevelopmental impairments. Whether these childhood antecedents index genetic liability is unknown. We used polygenic risk scores derived from a patient discovery sample as indicators of the genetic liability of schizophrenia. Our aim was to identify the early childhood manifestations of this liability in a UK population-based cohort. METHODS: The study sample was the Avon Longitudinal Study of Parents and Children, a prospective population-based cohort study of 14701 children...
December 5, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27931736/migraine-headache-trigger-site-prevalence-analysis-of-2590-sites-in-1010-patients
#7
Nazilla S Seyed Forootan, Michelle Lee, Bahman Guyuron
BACKGROUND: Surgical deactivation of migraine trigger sites offers an alternate treatment option for patients with recalcitrant headaches who are unresponsive to medical therapies or for those who are unable to take medications. The aim of this article is to provide a comprehensive review and a prevalence analysis of 2590 migraine surgery trigger sites in 1010 patients over a 14-year study period. METHODS: This is a retrospective review of migraine patients who underwent surgical decompression of peripheral nerves...
November 16, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27931564/taking-care-of-relationships-in-the-intensive-care-unit-positive-impact-on-family-consent-for-organ-donation
#8
M G Bocci, C D'Alò, R Barelli, S Inguscio, A Prestifilippo, S Di Paolo, S Lochi, M Fanfarillo, D L Grieco, R Maviglia, A Caricato, G Mistraletti, S Pulitanò, M Antonelli, C Sandroni
BACKGROUND: Organ donation refusal from relatives of potential donors with brain death significantly reduces organ availability. The need for organ donation has increased over time, but the shortage of available donors is the major limiting factor in transplantation. We analyzed the impact of a new systematic communication approach between medical staff and patients' relatives on the rate of consent to organ donation. METHODS: The study was conducted as a single-center, non-randomized, controlled, before-and-after study at an 18-bed intensive care unit (ICU) of a university hospital...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931533/care-transition-interventions-for-children-with-asthma-in-the-emergency-department
#9
REVIEW
Molly A Martin, Valerie G Press, Sharmilee M Nyenhuis, Jerry A Krishnan, Kim Erwin, Giselle Mosnaim, Helen Margellos-Anast, S Margaret Paik, Stacy Ignoffo, Michael McDermott
The emergency department (ED) is a critical point of identification and treatment for some of the most high-risk children with asthma. This review summarizes the evidence regarding care transition interventions originating in the ED for children with uncontrolled asthma, with a focus on care coordination and self-management education. Although many interventions on care transition for pediatric asthma have been tested, only a few were actually conducted in the ED setting. Most of these targeted both care coordination and self-management education but ultimately did not improve attendance at follow-up appointments with primary care providers, improve asthma control, or reduce health care utilization...
December 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27931048/neurodevelopment-and-health-related-quality-of-life-in-infants-born-with-gastroschisis-a-6-year-retrospective-french-study
#10
Barthelemy Tosello, Meriem Zahed, Floriane Guimond, Karine Baumstarck, Alice Faure, Fabrice Michel, Olivier Claris, Jerome Massardier, Catherine Gire, Thierry Merrot
Introduction Quantify quality of life (QoL) outcomes in gastroschisis children is little assessed. The primary objective was to describe the long-term outcome of newborns with gastroschisis treated in three tertiary care hospitals of France in terms of neurodevelopment and QoL. Materials and Methods The study reported was a cross-sectional, descriptive multicentric retrospective study assessing the outcome of newborns with gastroschisis, born between January 1, 2009, and December 31, 2014, treated at two large and French level III neonatal intensive care units...
December 8, 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27930610/using-mhealth-for-hiv-tb-treatment-support-in-lesotho-enhancing-patient-provider-communication-in-the-start-study
#11
Yael Hirsch-Moverman, Amrita Daftary, Katharine A Yuengling, Suzue Saito, Moeketsi Ntoane, Koen Frederix, Llang B Maama, Andrea A Howard
BACKGROUND: mHealth is a promising means of supporting adherence to treatment. The Start TB patients on ART and Retain on Treatment (START) study included real-time adherence support using short-text messaging service (SMS) text messaging and trained village health workers (VHWs). We describe the use and acceptability of mHealth by patients with HIV/tuberculosis and health care providers. METHODS: Patients and treatment supporters received automated, coded medication and appointment reminders at their preferred time and frequency, using their own phones, and $3...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27930369/measuring-moral-distress-among-critical-care-clinicians-validation-and-psychometric-properties-of-the-italian-moral-distress-scale-revised
#12
Giulia Lamiani, Ilaria Setti, Luca Barlascini, Elena Vegni, Piergiorgio Argentero
OBJECTIVES: Moral distress is a common experience among critical care professionals, leading to frustration, withdrawal from patient care, and job abandonment. Most of the studies on moral distress have used the Moral Distress Scale or its revised version (Moral Distress Scale-Revised). However, these scales have never been validated through factor analysis. This article aims to explore the factorial structure of the Moral Distress Scale-Revised and develop a valid and reliable scale through factor analysis...
December 7, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27928501/patient-prioritization-of-comorbid-chronic-conditions-in-the-veteran-population-implications-for-patient-centered-care
#13
Lorilei M Richardson, Jennifer N Hill, Bridget M Smith, Erica Bauer, Frances M Weaver, Howard S Gordon, Kevin T Stroupe, Timothy P Hogan
OBJECTIVE: Patients with comorbid chronic conditions may prioritize some conditions over others; however, our understanding of factors influencing those prioritizations is limited. In this study, we sought to identify and elaborate a range of factors that influence how and why patients with comorbid chronic conditions prioritize their conditions. METHODS: We conducted semi-structured, one-on-one interviews with 33 patients with comorbidities recruited from a single Veterans Health Administration Medical Center...
2016: SAGE Open Medicine
https://www.readbyqxmd.com/read/27928188/impact-of-the-fda-warning-for-azithromycin-and-risk-for-qt-prolongation-on-utilization-at-an-academic-medical-center
#14
Abby Dunker, Denise M Kolanczyk, Caitlin M Maendel, Amit R Patel, Natasha N Pettit
A US Food and Drug Administration (FDA) drug safety communication was released in March 2013, warning prescribers of the risk of QT prolongation associated with azithromycin. Overall azithromycin utilization and adherence to an inpatient QTc monitoring guideline during 8-month time periods before and after the warning were assessed to evaluate the impact of this warning on inpatient azithromycin utilization and QTc monitoring. Fifty-five patients were included in the prewarning time period and 50 were included in the postwarning period...
November 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27928086/barriers-to-linkage-to-care-for-hepatitis-b-virus-infection-a-qualitative-analysis-in-burkina-faso-west-africa
#15
Tamara Giles-Vernick, Fabienne Hejoaka, Armande Sanou, Yusuke Shimakawa, Issiaka Bamba, Abdoulaye Traoré
Hepatitis B virus (HBV) infection is a critical global health problem. The World Health Organization (WHO) has recently developed a global elimination strategy for HBV infection. Increasing access to screening, liver assessment, and antiviral treatment are crucial steps in achieving this goal. Little is known, however, about obstacles to linkage to care in low- and middle-income countries. Using a grounded theory approach, this qualitative study sought to characterize the diagnostic itineraries of people with chronic HBV infection in Burkina Faso, a west African country with high HBV prevalence, to identify barriers to linkage from screening to specialist care with hepatic assessment (alanine transaminase and hepatitis B e antigen or HBV DNA)...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27927920/validation-of-autoclave-protocols-for-the-successful-decontamination-of-category-a-medical-waste-generated-from-the-care-of-patients-with-serious-communicable-diseases
#16
Brian T Garibaldi, Mallory Reimers, Neysa Ernst, Gregory Bova, Elaine Nowakowski, James Bukowski, Brandon C Ellis, Chris Smith, Lauren Sauer, Kim Dionne, Karen C Carroll, Lisa L Maragakis, Nicole M Parrish
In response to the Ebola outbreak in 2014, many hospitals designated specific areas to care for patients with Ebola and other highly infectious diseases. The safe handling of Category A infectious substances is a unique challenge in this environment. One solution is onsite waste treatment with a steam sterilizer or autoclave. The Johns Hopkins Hospital (JHH) installed two pass-through autoclaves in its Biocontainment Unit (BCU). The JHH BCU and The Johns Hopkins Biosafety Level 3 Clinical Microbiology Laboratory designed and validated waste handling protocols with simulated patient trash to ensure adequate sterilization...
December 7, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27927669/getting-it-right-study-protocol-to-determine-the-diagnostic-accuracy-of-a-culturally-specific-measure-to-screen-for-depression-in-aboriginal-and-or-torres-strait-islander-people
#17
Maree L Hackett, Sara Farnbach, Nick Glozier, Timothy Skinner, Armando Teixeira-Pinto, Deborah Askew, Graham Gee, Alan Cass, Alex Brown
INTRODUCTION: A freely available, culturally valid depression screening tool is required for use by primary care services across Australia to screen for depression in Aboriginal and/or Torres Strait Islander populations. This is the protocol for a study aiming to determine the validity, sensitivity and specificity of the culturally adapted 9-item Patient Health Questionnaire (aPHQ-9). METHODS AND ANALYSIS: Cross-sectional validation study. A total of 500 people who self-identify as Aboriginal and/or Torres Strait Islander, are ≥18 years of age, attending 1 of 10 primary healthcare services or service events across Australia and able to communicate sufficiently to answer study questions will be recruited...
December 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27927262/first-successful-pre-distribution-of-stable-iodine-tablets-under-japan-s-new-policy-after-the-fukushima-daiichi-nuclear-accident
#18
Mayo Ojino, Sumito Yoshida, Takashi Nagata, Masami Ishii, Makoto Akashi
Stable iodine tablets are effective in reducing internal exposure to radioactive iodine, which poses a risk for thyroid cancer and other conditions. After the Fukushima Daiichi nuclear power plant accident, the Japanese government shifted its policy on stable iodine tablet distribution from "after-the-fact" to "before-the-fact" and instructed local governments to pre-distribute stable iodine tablets to residents living within a 5-km radius of nuclear facilities. The nation's first pre-distribution of stable iodine tablets was carried out in June and July of 2014 in Kagoshima Prefecture...
December 8, 2016: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/27926908/community-perceptions-of-biobanking-participation-a-qualitative-study-among-mexican-americans-in-three-texas-cities
#19
Natalia I Heredia, Sarah Krasny, Larkin L Strong, Laura Von Hatten, Lynne Nguyen, Belinda M Reininger, Lorna H McNeill, María E Fernández
BACKGROUND: Most biospecimens in the US are collected from non-Hispanic Whites, limiting the generalizability of findings. There is a need to increase participation in biobanking among ethnic and racial minorities. The purpose of this study was to use qualitative methods to identify factors that may influence Mexican-American individuals' willingness to participate in biobanking. METHODS: We conducted 15 focus groups in three Texas cities with Mexican-American individuals, in both Spanish and English...
December 8, 2016: Public Health Genomics
https://www.readbyqxmd.com/read/27926808/evaluation-of-communication-and-acceptance-of-the-patients-by-medical-personnel
#20
Anna Włoszczak-Szubzda, Mirosław J Jarosz, Mariusz Goniewicz, Krzysztof Goniewicz
Background: The low level of patient satisfaction recorded in many studies and, at the same time, the level of frustration and burnout, disclosed by medics in the perception of the patient as a ‘problem’, incline to look for the causes of inadequate relationship between physician and patient. Objective: The aim of this study was to evaluate the level of acceptance of the patient by the medical personnel. The research problem was the acceptance level which was within the range of the communication skills of the nurses and doctors...
2016: Roczniki Państwowego Zakładu Higieny
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