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Vitamin d survival

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https://www.readbyqxmd.com/read/28928387/bi-directional-effects-of-vitamin-b12-and-methotrexate-on-daphnia-magna-fitness-and-genomic-methylation
#1
Fitore Kusari, Alan M O'Doherty, Nikolas J Hodges, Marcin W Wojewodzic
Here we interrogated, using three separate but complementary experimental approaches, the impact of vitamin B12 availability and methotrexate exposure on Daphnia magna, which we hypothesised should have an opposite effect on One carbon metabolism (OCM). OCM is a vital biological process supporting a variety of physiological processes, including DNA methylation. Contrary to mammalian models, this process remains largely unexplored in invertebrates. The purpose of this study was to elucidate the impact of OCM short-term alteration on the fitness and epigenome of the keystone species, Daphnia...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910790/the-cardiovascular-burden-in-end-stage-renal-disease
#2
Mario Cozzolino, Andrea Galassi, Francesca Pivari, Paola Ciceri, Ferruccio Conte
It is well documented that chronic kidney disease patients have an extremely high risk of developing cardiovascular (CV) disease (CVD) compared to the general population. Declining renal function itself represents a continuum of CV risk, and in those individuals who survive to reach end-stage renal disease, the risk of suffering a cardiac event is uncomfortably and unacceptably high. Several pathophysiological pathways have been suggested to account for this, including endothelial dysfunction, dyslipidemia, inflammation, left ventricular hypertrophy, troponins, phosphate, vitamin D, fibroblast growth factor-23, and NT-proBNP...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28901396/effect-of-1-25-oh-2d3-on-high-glucose%C3%A2-induced-autophagy-inhibition-in-peritoneum
#3
Lina Yang, Yi Fan, Xiuli Zhang, Jin Liu, Jianfei Ma
High glucose (HG) may damage the structure and function of the peritoneal membrane, and is considered to be one of the most important factors that leads to peritoneal fibrosis and ultrafiltration failure. Recently, 1,25(OH)2D3, the active form of vitamin D, was demonstrated to protect against epithelial‑mesenchymal transition and fibrosis in peritoneal mesothelium and other organs. Accumulating evidence has suggested that autophagy serves a protective role in certain diseases by regulating cell survival...
August 31, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28892825/associations-between-vitamin-d-intake-and-progression-to-incident-advanced-age-related-macular-degeneration
#4
Bénédicte M J Merle, Rachel E Silver, Bernard Rosner, Johanna M Seddon
Purpose: There is growing evidence of the importance of nutrition in age-related macular degeneration (AMD), but no prospective studies have explored the impact of vitamin D. We evaluated the association between vitamin D intake and progression to advanced AMD. Methods: Among 2146 participants (3965 eyes), 541 (777 eyes) progressed from early or intermediate AMD to advanced disease (mean follow-up: 9.4 years) based on ocular imaging. Nutrients were log transformed and calorie adjusted...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28891732/effects-of-vitamin-d-supplementation-on-carotid-intima-media-thickness-in-hiv-infected-youth
#5
Allison Ross Eckard, Paolo Raggi, Mary Ann O'Riordan, Julia C Rosebush, Danielle Labbato, Ann Chahroudi, Joshua H Ruff, Christopher T Longenecker, Vin Tangpricha, Grace A McComsey
Viral suppression with combination antiretroviral therapy (cART) dramatically improves survival in HIV-infected individuals. Yet, this population has more age-related co-morbidities, especially cardiovascular disease (CVD), and these co-morbidities occur at an earlier age than in the general population (1) . Similar to their adult counterparts, data show that HIV-infected youth are also at an increased risk of development of these HIV-related co-morbidities later in life, despite few clinical manifestations in younger age (2) ...
September 11, 2017: Virulence
https://www.readbyqxmd.com/read/28886484/augmentation-of-intracellular-iron-using-iron-sucrose-enhances-the-toxicity-of-pharmacological-ascorbate-in-colon-cancer-cells
#6
Kristin E Brandt, Kelly C Falls, Joshua D Schoenfeld, Samuel N Rodman, Zhimin Gu, Fenghuang Zhan, Joseph J Cullen, Brett A Wagner, Garry R Buettner, Bryan G Allen, Daniel J Berg, Douglas R Spitz, Melissa A Fath
Pharmacological doses (> 1mM) of ascorbate (a.k.a., vitamin C) have been shown to selectively kill cancer cells through a mechanism that is dependent on the generation of H2O2 at doses that are safely achievable in humans using intravenous administration. The process by which ascorbate oxidizes to form H2O2 is thought to be mediated catalytically by redox active metal ions such as iron (Fe). Because intravenous iron sucrose is often administered to colon cancer patients to help mitigate anemia, the current study assessed the ability of pharmacological ascorbate to kill colon cancer cells in the presence and absence of iron sucrose...
August 26, 2017: Redox Biology
https://www.readbyqxmd.com/read/28884317/relationship-of-very-low-serum-25-hydroxyvitamin-d3-levels-with-long-term-survival-in-a-large-cohort-of-colorectal-cancer-patients-from-germany
#7
Haifa Maalmi, Viola Walter, Lina Jansen, Jenny Chang-Claude, Robert W Owen, Alexis Ulrich, Ben Schöttker, Michael Hoffmeister, Hermann Brenner
To investigate the association of serum 25-hydroxyvitamin D (25(OH)D3) with survival in a large prospective cohort study of colorectal cancer (CRC) patients. The study population consisted of 2,910 patients diagnosed with CRC between 2003 and 2010 who participated in the DACHS study, a multicenter study from Germany with comprehensive long-term follow-up. 25(OH)D3 was determined in serum samples collected shortly after cancer diagnosis by High Performance Liquid Chromatography-Electro Spray Ionization-Mass Spectrometry...
September 7, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28878084/human-herpesvirus-8-interleukin-6-interacts-with-calnexin-cycle-components-and-promotes-protein-folding
#8
Daming Chen, Qiwang Xiang, John Nicholas
Viral interleukin-6 (vIL-6) encoded by human herpesvirus 8 (HHV-8) is believed to contribute via mitogenic, survival, and angiogenic activities to HHV-8-associated Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease through autocrine or paracrine mechanisms during latency or productive replication. There is direct evidence that vIL-6 promotes latently infected PEL cell viability and proliferation and also viral productive replication in PEL and endothelial cells. These activities are mediated largely through endoplasmic reticulum (ER)-localized vIL-6, which can induce signal transduction via the gp130 signaling receptor, activating mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) signaling, and interactions of vIL-6 with the ER membrane protein vitamin K epoxide reductase complex subunit 1 variant 2 (VKORC1v2)...
September 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28871411/histodifferentiation-of-oil-palm-somatic-embryo-development-at-low-auxin-concentration
#9
M S Pádua, R S Santos, C R G Labory, V C Stein, E G Mendonça, E Alves, L V Paiva
Large-scale propagation of oil palm (Elaeis guineensis, Jacq.) is difficult due to its single apical meristem. Thus, obtaining plants is mainly through seed germination, and a long growing period is required before oil production is possible. An alternative to large-scale seedling production is indirect somatic embryogenesis. The aim of this study was to analyze the somatic embryogenesis process in oil palm (E. guineensis Jacq.) with amino acids and low concentrations of auxins. The Tenera hybrid was analyzed by cytochemical and ultrastructural methods and was used to regenerate oil palm plants...
September 4, 2017: Protoplasma
https://www.readbyqxmd.com/read/28868183/effect-of-replenishment-of-vitamin-d-on-survival-in-patients-with-decompensated-liver-cirrhosis-a-prospective-study
#10
Ashish Kumar Jha, Sharad Kumar Jha, Amarendra Kumar, Vishwa Mohan Dayal, Sanjeev Kumar Jha
AIM: To assess the vitamin D (VD) deficiency as a prognostic factor and effect of replenishment of VD on mortality in decompensated cirrhosis. METHODS: Patients with decompensated liver cirrhosis were screened for serum VD levels. A total of 101 VD deficient patients (< 20 ng/mL) were randomly enrolled in two groups: Treatment group (n = 51) and control group (n = 50). Treatment group received VD treatment in the form of intramuscular cholecalciferol 300000 IU as loading dose and 800 IU/d oral as maintenance dose along with 1000 mg oral calcium supplementation...
August 15, 2017: World Journal of Gastrointestinal Pathophysiology
https://www.readbyqxmd.com/read/28841366/mortality-and-transcriptional-effects-of-inorganic-mercury-in-the-marine-copepod-calanus-finmarchicus
#11
Knut Erik Tollefsen, You Song, Tore Høgåsen, Ida Beathe Øverjordet, Dag Altin, Bjørn Henrik Hansen
Inorganic mercury (Hg) is highly toxic to organisms including crustaceans and displays multiple toxic modes of action (MoA). The main aim of this investigation was to assess the acute and sublethal toxicity mediated by mercury chloride (HgCl2) in the marine copepod Calanus finmarchicus. A combination of short-term static studies to determine acute toxicity and a transcriptional investigation to characterize the sublethal MoA of HgCl2 were conducted with an in-house continuous culture of C. finmarchicus. Transcriptional changes were determined by a custom 6...
August 25, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28841207/vitamin-d-insufficiency-is-associated-with-an-increased-risk-of-early-clinical-failure-in-follicular-lymphoma
#12
S I Tracy, M J Maurer, T E Witzig, M T Drake, S M Ansell, G S Nowakowski, C A Thompson, D J Inwards, P B Johnston, I N Micallef, C Allmer, W R Macon, G J Weiner, S L Slager, T M Habermann, B K Link, J R Cerhan
We evaluated whether vitamin D insufficiency (VDI; 25(OH)D <20 ng/ml) was associated with adverse outcomes among follicular lymphoma (FL) patients using an observational prospective cohort study of 642 FL patients enrolled from 2002-2012. The median age at diagnosis was 60 years. At a median follow-up of 59 months, 297 patients (46%) had an event (progression, treatment failure), 78 had died and 42 (6.5%) had a lymphoma-related death. VDI was associated with inferior event-free survival (EFS) at 12 months (EFS12, odds ratio (OR)=2...
August 25, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28840578/bone-mineral-density-is-lower-in-patients-with-severe-knee-osteoarthritis-and-attrition
#13
Karina Nørgaard Linde, Katriina Bøcker Puhakka, Bente Lomholt Langdahl, Kjeld Søballe, Inger Krog-Mikkelsen, Frank Madsen, Maiken Stilling
Bone quality is probably important for the survival of knee arthroplasty (KA), but little is known about systemic bone mineral density and bone turnover in patients prior to KA surgery. The aim of this study was to explore the prevalence of osteoporosis and bone turnover in relation to knee osteoarthritis (OA) grade in patients scheduled for KA surgery. Prospective preoperative evaluation of 450 patients (259 females) prior to KA between 2014 and 2016 with standing knee radiography, Dual-energy X-ray absorptiometry (DXA), biomarkers for bone turnover (CTX, P1NP), and vitamin D...
August 24, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28835228/vitamin-d-supplementation-in-cutaneous-malignant-melanoma-outcome-vidme-a-randomized-controlled-trial
#14
J De Smedt, S Van Kelst, V Boecxstaens, M Stas, K Bogaerts, D Vanderschueren, C Aura, K Vandenberghe, D Lambrechts, P Wolter, O Bechter, A Nikkels, T Strobbe, G Emri, V Marasigan, M Garmyn
BACKGROUND: Previous studies have investigated the protective effect of vitamin D serum levels, at diagnosis and during the follow-up period after treatment, on melanoma outcome. In the present study we assess whether vitamin D supplementation, in the follow-up period after diagnosis and surgical resection of the primary tumor, has a protective effect on relapse of cutaneous malignant melanoma and whether this protective effect correlates with vitamin D levels in serum and Vitamin D Receptor immunoreactivity in the primary tumor...
August 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28829157/vitamin-d-supplements-reduce-depressive-symptoms-and-cardiac-events-in-heart-failure-patients-with-moderate-to-severe-depressive-symptoms
#15
Eun Kyeung Song, Jia-Rong Wu, Debra K Moser, Seok-Min Kang, Terry A Lennie
BACKGROUND: Depressive symptoms and vitamin D deficiency predict cardiac events in heart failure patients, but whether vitamin D supplements are associated with depressive symptoms and cardiac events in heart failure patients remains unknown. PURPOSE: The purpose of this study was to compare the association of vitamin D supplement use with depressive symptoms and cardiac events in heart failure patients with mild or moderate to severe depressive symptoms. METHODS: A total of 177 heart failure patients with depressive symptoms (Patient Health Questionnaire-9 score ≥5) completed a three-day food diary to determine dietary vitamin D deficiency...
August 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28816551/1%C3%AE-25-dihydroxyvitamin-d3-up-regulates-il-34-expression-in-sh-sy5y-neural-cells
#16
Dong Zhang, Miaomiao Li, Yang Dong, Xinhui Zhang, Xingyun Liu, Zhangming Chen, Yongji Zhu, Huiming Wang, Xuwen Liu, Jialiang Zhu, Yujun Shen, Heinrich Korner, Songcheng Ying, Shengyun Fang, Yuxian Shen
Vitamin D supplementation is regarded as a novel approach to treat Alzheimer's disease, but the underlying mechanism remains elusive. The cytokine IL-34 provides strong neuroprotective and survival signals in brain injury and neurodegeneration and could be an immunological mediator for the vitamin D-induced protection. The aim of this study was to investigate whether human IL-34 is up-regulated in neuronal cells by the hormonally active form of vitamin D, 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3]. We found that IL-34 was detectable in a variety of cell lines and its expression was strongly induced in SH-SY5Y neural cells in a dose- and time-dependent manner by 1α,25(OH)2D3 through the vitamin D receptor (VDR)...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/28811844/lsd1-dual-function-in-mediating-epigenetic-corruption-of-the-vitamin-d-signaling-in-prostate-cancer
#17
Sebastiano Battaglia, Ellen Karasik, Bryan Gillard, Jennifer Williams, Trisha Winchester, Michael T Moser, Dominic J Smiraglia, Barbara A Foster
BACKGROUND: Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. Here, we demonstrate that LSD1 regulates vitamin D receptor (VDR) activity and is a mediator of 1,25(OH)2-D3 (vitamin D) action in prostate cancer (PCa). METHODS: Athymic nude mice were xenografted with CWR22 cells and monitored weekly after testosterone pellet removal. Expression of LSD1 and VDR (IHC) were correlated with tumor growth using log-rank test...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28771378/pretransplant-vitamin-d-deficiency-is-associated-with-higher-relapse-rates-in-patients-allografted-for-myeloid-malignancies
#18
Aleksandar Radujkovic, Lambros Kordelas, Julia Krzykalla, Dietrich W Beelen, Axel Benner, Nicola Lehners, Katharina Schmidt, Peter Dreger, Thomas Luft
Purpose Vitamin D (VitD) deficiency is common in patients with hematologic malignancies undergoing allogeneic transplantation (alloSCT), but its prognostic relevance is unclear. Patients and Methods The impact of pretransplant VitD status on overall survival, relapse mortality, and nonrelapse mortality was investigated retrospectively in a cohort of 492 patients undergoing alloSCT at our center from 2002 to 2013. VitD deficiency was defined as a serum level of 25-hydroxyvitamin D3 < 20 ng/mL (equivalent to < 50 nM) before alloSCT and was assessed using accredited laboratory methods and a standard chemiluminescent immunoassay...
September 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28765616/vitamin-d-receptor-and-calcium-sensing-receptor-polymorphisms-and-colorectal-cancer-survival-in-the-newfoundland-population
#19
Yun Zhu, Peizhong Peter Wang, Guangju Zhai, Bharati Bapat, Sevtap Savas, Jennifer R Woodrow, Ishor Sharma, Yuming Li, Xin Zhou, Ning Yang, Peter T Campbell, Elizabeth Dicks, Patrick S Parfrey, John R Mclaughlin
BACKGROUND: Increased serum levels of vitamin D and calcium have been associated with lower risks of colorectal cancer (CRC) incidence and mortality. These inverse associations may be mediated by the vitamin D receptor (VDR) and the calcium-sensing receptor (CASR). We investigated genetic variants in VDR and CASR for their relevance to CRC prognosis. METHODS: A population-based cohort of 531 CRC patients diagnosed from 1999 to 2003 in Newfoundland and Labrador, Canada, was followed for mortality and cancer recurrence until April 2010...
September 5, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28765041/evidence-for-altered-osteoclastogenesis-in-splenocyte-cultures-from-vdr-knockout-mice
#20
Daniel C Reinke, Yolandi Starczak, Masakazu Kogawa, Kate R Barratt, Howard A Morris, Paul H Anderson, Gerald J Atkins
The indirect action of 1α,25(OH)2-vitamin-D3 (1,25D) on the osteoclast through stromal signalling is well established. The role of vitamin D in osteoclasts through direct 1,25D-VDR signalling is less well known. We showed previously that local 1,25D synthesis in osteoclasts modified osteoclastogenesis and osteoclastic resorptive activity. In this study, we hypothesised that osteoclasts lacking VDR expression would display an enhanced resorptive capacity due to the loss of 1,25D signalling. Splenocytes were cultured under osteoclast-differentiating conditions from mice with global deletion of the Vdr gene (VDRKO) and this was compared with age-matched wild-type littermate controls (WT)...
July 29, 2017: Journal of Steroid Biochemistry and Molecular Biology
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