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https://www.readbyqxmd.com/read/29913528/blood-pressure-and-cognitive-performance-after-a-single-administration-of-a-camphor-crataegus-combination-in-adolescents-with-low-blood-pressure
#1
Rainer Schandry, Daniela Lindauer, Matthias Mauz
Low blood pressure is rather widespread among adolescents and frequently accompanied by complaints. Two single-center, double-blinded, randomized, and placebo-controlled trials were performed with adolescent participants in the age range of 14 - 17 y having a systolic blood pressure below 118 mmHg (boys) or 110 mmHg (girls). They received a single dose of 20 drops of a fixed combination of natural D-camphor and an ethanolic extract from fresh Crataegus berries (CCC) or of an ethanolic placebo. The efficacy of CCC (commercial name Korodin) has proven its efficacy in the treatment of low blood pressure in adults of all ages, although related placebo-controlled, double-blind studies for adolescents following European (EU) pediatric regulations are lacking...
June 18, 2018: Planta Medica
https://www.readbyqxmd.com/read/29913256/the-effect-of-glucocorticoids-on-bone-mineral-density-in-patients-with-rheumatoid-arthritis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
Anne-Birgitte Blavnsfeldt, Annette de Thurah, Malissa Dawn Thomsen, Simon Tarp, Bente Langdahl, Ellen-Margrethe Hauge
PURPOSE: The role of glucocorticoids in the treatment of rheumatoid arthritis (RA) is widely debated. Impairment of bone formation may be counter-balanced by reduced systemic inflammation. This review aims to assess the effect of prednisolone/prednisone on bone mineral density (BMD) in patients with RA analyzed in randomized, controlled trials. METHODS: We performed a systematic literature search and identified randomized, double-blinded placebo-controlled studies including patients with RA and using prednisolone or prednisone as the intervention...
June 15, 2018: Bone
https://www.readbyqxmd.com/read/29913020/effect-of-tamsulosin-on-passage-of-symptomatic-ureteral-stones-a-randomized-clinical-trial
#3
Andrew C Meltzer, Pamela Katzen Burrows, Allan B Wolfson, Judd E Hollander, Michael Kurz, Ziya Kirkali, John W Kusek, Patrick Mufarrij, Stephen V Jackman, Jeremy Brown
Importance: Urinary stone disease is a common presentation in the emergency department, and α-adrenergic receptor blockers, such as tamsulosin, are commonly used to facilitate stone passage. Objective: To determine if tamsulosin promotes the passage of urinary stones within 28 days among emergency department patients. Design, Setting, and Participants: We conducted a double-blind, placebo-controlled clinical trial from 2008 to 2009 (first phase) and then from 2012 to 2016 (second phase)...
June 18, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29913017/safety-and-tolerability-of-multiple-ascending-doses-of-prx002-rg7935-an-anti-%C3%AE-synuclein-monoclonal-antibody-in-patients-with-parkinson-disease-a-randomized-clinical-trial
#4
Joseph Jankovic, Ira Goodman, Beth Safirstein, Tonya K Marmon, Dale B Schenk, Martin Koller, Wagner Zago, Daniel K Ness, Sue G Griffith, Michael Grundman, Jay Soto, Susanne Ostrowitzki, Frank G Boess, Meret Martin-Facklam, Joseph F Quinn, Stuart H Isaacson, Omid Omidvar, Aaron Ellenbogen, Gene G Kinney
Importance: Aggregated α-synuclein is believed to be central to the pathogenesis of Parkinson disease (PD). PRX002/RG7935 (PRX002) is a humanized monoclonal antibody designed to target aggregated forms of α-synuclein, thereby inhibiting neuron-to-neuron transfer of presumed pathogenic forms of α-synuclein, potentially resulting in neuronal protection and slowing disease progression. Objective: To evaluate the safety and tolerability of multiple intravenous infusions of PRX002 in patients with idiopathic PD...
June 18, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29913015/comparison-of-safety-and-efficacy-of-methadone-vs-morphine-for-treatment-of-neonatal-abstinence-syndrome-a-randomized-clinical-trial
#5
Jonathan M Davis, Jeffrey Shenberger, Norma Terrin, Janis L Breeze, Mark Hudak, Elisha M Wachman, Peter Marro, Erica L Oliveira, Karen Harvey-Wilkes, Adam Czynski, Barbara Engelhardt, Karen D'Apolito, Debra Bogen, Barry Lester
Importance: Although opioids are used to treat neonatal abstinence syndrome (NAS), the best pharmacologic treatment has not been established. Objective: To compare the safety and efficacy of methadone and morphine in NAS. Design, Setting, and Participants: In this randomized, double-blind, intention-to-treat trial, term infants from 8 US newborn units whose mothers received buprenorphine, methadone, or opioids for pain control during pregnancy were eligible...
June 18, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29912983/efficacy-of-melatonin-with-behavioural-sleep-wake-scheduling-for-delayed-sleep-wake-phase-disorder-a-double-blind-randomised-clinical-trial
#6
Tracey L Sletten, Michelle Magee, Jade M Murray, Christopher J Gordon, Nicole Lovato, David J Kennaway, Stella M Gwini, Delwyn J Bartlett, Steven W Lockley, Leon C Lack, Ronald R Grunstein, Shantha M W Rajaratnam
BACKGROUND: Delayed Sleep-Wake Phase Disorder (DSWPD) is characterised by sleep initiation insomnia when attempting sleep at conventional times and difficulty waking at the required time for daytime commitments. Although there are published therapeutic guidelines for the administration of melatonin for DSWPD, to our knowledge, randomised controlled trials are lacking. This trial tested the efficacy of 0.5 mg melatonin, combined with behavioural sleep-wake scheduling, for improving sleep initiation in clinically diagnosed DSWPD patients with a delayed endogenous melatonin rhythm relative to patient-desired (or -required) bedtime (DBT)...
June 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29912955/oxytocin-receptor-gene-variations-and-socio-emotional-effects-of-mdma-a-pooled-analysis-of-controlled-studies-in-healthy-subjects
#7
Patrick Vizeli, Matthias E Liechti
Methylenedioxymethamphetamine (MDMA) increases oxytocin, empathy, and prosociality. Oxytocin plays a critical role in emotion processing and social behavior and has been shown to mediate the prosocial effects of MDMA in animals. Genetic variants, such as single-nucleotide polymorphisms (SNPs), of the oxytocin receptor (OXTR) may influence the emotional and social effects of MDMA in humans. The effects of common genetic variants of the OXTR (rs53576, rs1042778, and rs2254298 SNPs) on the emotional, empathogenic, and prosocial effects of MDMA were characterized in up to 132 healthy subjects in a pooled analysis of eight double-blind, placebo-controlled studies...
2018: PloS One
https://www.readbyqxmd.com/read/29912858/effect-of-caffeine-on-sprint-cycling-in-experienced-cyclists
#8
Dawn E Anderson, Sarah E LeGrand, Reece D McCart
Anderson, DE, LeGrand, SE, and McCart, RD. Effect of caffeine on sprint cycling in experienced cyclists. J Strength Cond Res XX(X): 000-000, 2018-Research regarding the ergogenic effects of caffeine (CAF) in anaerobic activity remains inconclusive. However, some researchers have found significant improvements in anaerobic performance when testing specifically trained athletes. A double-blind, placebo-controlled, counterbalanced, cross-over design was implemented to assess the impact of CAF on a 30-second Wingate Anaerobic Test (WAnT) in experienced cyclists...
June 15, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29912799/adjunct-aripiprazole-reduces-prolactin-and-prolactin-related-adverse-effects-in-premenopausal-women-with-psychosis-results-from-the-daamsel-clinical-trial
#9
Deanna L Kelly, Megan M Powell, Heidi J Wehring, MacKenzie A Sayer, Ann Marie Kearns, Ann L Hackman, Robert W Buchanan, Rebecca B Nichols, Heather A Adams, Charles M Richardson, Gopal Vyas, Robert P McMahon, Amber K Earl, Kelli M Sullivan, Fang Liu, Sarah E Luttrell, Faith B Dickerson, Stephanie M Feldman, Supriya Narang, Maju M Koola, Peter F Buckley, Jill A RachBeisel, Joseph P McEvoy
PURPOSE/BACKGROUND: Prolactin-related adverse effects contribute to nonadherence and adverse health consequences, particularly in women with severe mental illness. Treating these adverse effects may improve treatment acceptability, adherence, and long-term outcomes. METHODS/PROCEDURES: Premenopausal women with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder were recruited for a randomized, double-blind, placebo-controlled 16-week trial of adjunct aripiprazole (5-15 mg/d)...
June 15, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912570/the-use-of-a-stem-and-leaf-aqueous-extract-of-cissus-quadrangularis-cqr-300-to-reduce-body-fat-and-other-components-of-metabolic-syndrome-in-overweight-participants
#10
Robert Nash, Boris Azantsa, Dieudonne Kuate, Harrinder Singh, Julius Oben
BACKGROUND: Previous work had shown the ability of an aqueous leaf and stem extract of Cissus quandrangularis (300 mg of CQR, CQR-300) to improve components of metabolic syndrome (MS) in overweight individuals. OBJECTIVE: This small pilot study aimed to confirm the efficacy of CQR-300 in reducing the percentage body fat measured using two different methods-bioelectrical impedance assay versus dual-energy X-ray absorptiometry (DEXA). DESIGN: The study was an 8-week double-blind, placebo-controlled pilot trial on 67 individuals who were requested by a dietary counselor to maintain their normal exercise and dietary routines...
June 18, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29912453/induction-of-cross-clade-antibody-and-t-cell-responses-by-an-mva-based-influenza-h5n1-vaccine-in-a-randomized-phase-i-iia-clinical-trial
#11
Rory D de Vries, Arwen F Altenburg, Nella J Nieuwkoop, Erwin de Bruin, Stella E van Trierum, Mark R Pronk, Mart M Lamers, Mathilde Richard, David F Nieuwenhuijse, Marion P G Koopmans, Joost H C M Kreijtz, Ron A M Fouchier, Albert D M E Osterhaus, Gerd Sutter, Guus F Rimmelzwaan
Background: Highly pathogenic avian influenza viruses continue to circulate in poultry and wild birds and occasionally infect humans, sometimes with fatal outcome. Development of vaccines is a priority to prepare for potential pandemics, however complicated by antigenic variation of the surface glycoprotein hemagglutinin. We report the immunological profile induced by human immunization with Modified Vaccinia virus Ankara expressing the hemagglutinin gene of H5N1 virus A/Vietnam/1194/04 (rMVA-H5)...
April 18, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29912318/bayesian-inference-for-network-meta-regression-using-multivariate-random-effects-with-applications-to-cholesterol-lowering-drugs
#12
Hao Li, Ming-Hui Chen, Joseph G Ibrahim, Sungduk Kim, Arvind K Shah, Jianxin Lin, Andrew M Tershakovec
Low-density lipoprotein cholesterol (LDL-C) has been identified as a causative factor for atherosclerosis and related coronary heart disease, and as the main target for cholesterol- and lipid-lowering therapy. Statin drugs inhibit cholesterol synthesis in the liver and are typically the first line of therapy to lower elevated levels of LDL-C. On the other hand, a different drug, Ezetimibe, inhibits the absorption of cholesterol by the small intestine and provides a different mechanism of action. Many clinical trials have been carried out on safety and efficacy evaluation of cholesterol lowering drugs...
April 18, 2018: Biostatistics
https://www.readbyqxmd.com/read/29912271/randomized-phase-3-and-extension-studies-efficacy-and-impacts-on-quality-of-life-of-naldemedine-in-subjects-with-opioid-induced-constipation-and-cancer
#13
N Katakami, T Harada, T Murata, K Shinozaki, M Tsutsumi, T Yokota, M Arai, Y Tada, M Narabayashi, N Boku
Background: The efficacy and safety of naldemedine (a peripherally-acting µ-opioid receptor antagonist) for opioid-induced constipation (OIC) in subjects with cancer was demonstrated in the primary report of a phase 3, double-blind study (COMPOSE-4) and its open-label extension (COMPOSE-5). The primary endpoint, the proportion of spontaneous bowel movement (SBM) responders, was met. Here, we report results from secondary endpoints including quality of life (QOL) assessments from these studies...
April 18, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29912061/a-single-low-dose-of-hydrocortisone-enhances-cognitive-functioning-in-hiv-infected-women
#14
Leah H Rubin, K Luan Phan, Sheila M Keating, Pauline M Maki
OBJECTIVE: Low-dose hydrocortisone (LDH) enhances aspects of learning and memory in select populations including patients with PTSD and HIV-infected men. HIV-infected women show impairments in learning and memory, but the cognitive effects of LDH in HIV-infected women are unknown. DESIGN: Double-blind, placebo-controlled, cross-over study examining the time-dependent effects of a single low-dose administration of hydrocortisone (10 mg oral) on cognition in 36 HIV-infected women...
June 14, 2018: AIDS
https://www.readbyqxmd.com/read/29911636/differential-analgesic-effects-of-subanesthetic-concentrations-of-lidocaine-on-spontaneous-and-evoked-pain-in-human-painful-neuroma-a-randomized-double-blind-study
#15
Adriana Miclescu, Martin Schmelz, Torsten Gordh
Background Both peripheral nerve injury and neuroma pain are the result of changes in sodium channel expression. Lidocaine selectively inhibits the spontaneous ectopic activity by binding to sodium channels. Subanesthetics concentrations of lidocaine are able to produce a differential block of the ectopic discharges, but not propagation of impulses, suppressing differentially the associated neuropathic pain symptoms. The aim of this study was to investigate the differences between the analgesic effects of lidocaine 0...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911580/modulation-of-the-muscle-and-nerve-compound-muscle-action-potential-by-evoked-pain
#16
L Duez, E Qerama, T S Jensen, A Fuglsang-Frederiksen
Background and aims To our knowledge there are no studies that have examined the effects of the experimental pain on muscle fibre excitability as measured by the amplitudes of the potentials evoked by direct muscle stimulation (DMS) in a muscle at rest. We hypothesized that evoked pain can modulate the muscle compound action potential (CMAP) obtained by DMS possibly due to changes in muscle fibre excitability. Methods Pain was evoked by intramuscular infusion of hypertonic saline in 50 men. Ten control subjects were infused with isotonic saline...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29910837/intra-articular-injection-of-the-anti-inflammatory-compound-lmwf-5a-in-adults-with-severe-osteoarthritis-a-double-blind-prospective-randomized-controlled-multi-center-safety-and-efficacy-trial
#17
Kristin Salottolo, Brian Cole, David Bar-Or
Background: There are limited efficacious treatment options for severe osteoarthritis of the knee (OAK). The Low Molecular Weight Fraction of 5% human serum Albumin (LMWF-5A) is in development to treat severe OAK. This study evaluated the safety and efficacy of LMWF-5A for the signs and symptoms of OAK. Methods: This 12-week randomized, double-blind, controlled clinical trial was conducted at thirteen sites across the United States. Patients with symptomatic, severe OAK (Kellgren-Lawrence grade 4 disease) who were fully ambulatory and had no other conditions interfering with the study knee were randomized to a single 4 ml intra-articular injection of LMWF-5A or saline, randomized 6:1...
2018: Patient Safety in Surgery
https://www.readbyqxmd.com/read/29910611/long-term-safety-of-tiotropium-olodaterol-respimat-%C3%A2-in-patients-with-moderate-to-very-severe-copd-and-renal-impairment-in-the-tonado-%C3%A2-studies
#18
Craig LaForce, Eric Derom, Ulrich Bothner, Isabel M Kloer, Matthias Trampisch, Roland Buhl
Introduction: The safety, lung function efficacy, and symptomatic benefits of combined tiotropium and olodaterol in patients with COPD were established in the 1-year TONADO® studies (NCT01431274; NCT01431287). As tiotropium is predominantly excreted by the kidneys, the long-term safety profile of tiotropium/olodaterol was investigated in patients with renal impairment in a prespecified safety analysis of the TONADO studies. Methods: These were 2 replicate, randomized, double-blind, parallel-group, 52-week Phase III studies that assessed tiotropium/olodaterol compared with tiotropium or olodaterol alone (all via Respimat® ) in patients with moderate-to-very severe COPD...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29910495/effect-of-addition-of-dexamethasone-to-ropivacaine-on-post-operative-analgesia-in-ultrasonography-guided-transversus-abdominis-plane-block-for-inguinal-hernia-repair-a-prospective-double-blind-randomised-controlled-trial
#19
Uma Datt Sharma, Prateek, Himani Tak
Background and Aims: Ultrasonography (USG)-guided transversus abdominis plane (TAP) block is an abdominal field block with high efficacy. This study was undertaken with the aim of determining the effect of the addition of dexamethasone to 0.5% ropivacaine on post-operative analgesia in USG-guided TAP block for inguinal hernia repair. Methods: A double-blind randomised control study was conducted on sixty patients posted for inguinal hernia repair with the American Society of Anesthesiologists physical Status I or II, who were allocated two groups of 30 each...
May 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29910490/attenuation-of-the-pressor-responses-to-laryngoscopy-and-endotracheal-intubation-with-intravenous-dexmedetomidine-versus-magnesium-sulphate-under-bispectral-index-controlled-anaesthesia-a-placebo-controlled-prospective-randomised-trial
#20
Lakshmi Mahajan, Manjot Kaur, Ruchi Gupta, Kuljeet Singh Aujla, Avtar Singh, Ashreen Kaur
Background and Aims: Laryngoscopy and intubation cause sympathetic stimulation and arousal reactions. We evaluated the role of dexmedetomidine and magnesium sulphate on pressor responses to laryngoscopy and intubation as compared to placebo, when depth of anaesthesia was maintained at a constant bispectral index (BIS) range 40-50 (±5). Methods: One hundred and twenty patients were randomised to receive either dexmedetomidine 1 μg/kg (Group DS), magnesium sulphate 30 mg/kg diluted in 100 ml saline (Group MS) or 100 ml normal saline (Group NS) 15 min before induction of anaesthesia in a double blind manner...
May 2018: Indian Journal of Anaesthesia
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